---
_id: '13965'
abstract:
- lang: eng
  text: Many modes and mechanisms of epigenetic inheritance have been elucidated in
    eukaryotes. Most of them are relatively short-term, generally not exceeding one
    or a few organismal generations. However, emerging evidence indicates that one
    mechanism, cytosine DNA methylation, can mediate epigenetic inheritance over much
    longer timescales, which are mostly or completely inaccessible in the laboratory.
    Here we discuss the evidence for, and mechanisms and implications of, such long-term
    epigenetic inheritance. We argue that compelling evidence supports the long-term
    epigenetic inheritance of gene body methylation, at least in the model angiosperm
    Arabidopsis thaliana, and that variation in such methylation can therefore serve
    as an epigenetic basis for phenotypic variation in natural populations.
article_number: '102087'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Elizabeth
  full_name: Hollwey, Elizabeth
  id: b8c4f54b-e484-11eb-8fdc-a54df64ef6dd
  last_name: Hollwey
- first_name: Amy
  full_name: Briffa, Amy
  last_name: Briffa
- first_name: Martin
  full_name: Howard, Martin
  last_name: Howard
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Hollwey E, Briffa A, Howard M, Zilberman D. Concepts, mechanisms and implications
    of long-term epigenetic inheritance. <i>Current Opinion in Genetics and Development</i>.
    2023;81(8). doi:<a href="https://doi.org/10.1016/j.gde.2023.102087">10.1016/j.gde.2023.102087</a>
  apa: Hollwey, E., Briffa, A., Howard, M., &#38; Zilberman, D. (2023). Concepts,
    mechanisms and implications of long-term epigenetic inheritance. <i>Current Opinion
    in Genetics and Development</i>. Elsevier. <a href="https://doi.org/10.1016/j.gde.2023.102087">https://doi.org/10.1016/j.gde.2023.102087</a>
  chicago: Hollwey, Elizabeth, Amy Briffa, Martin Howard, and Daniel Zilberman. “Concepts,
    Mechanisms and Implications of Long-Term Epigenetic Inheritance.” <i>Current Opinion
    in Genetics and Development</i>. Elsevier, 2023. <a href="https://doi.org/10.1016/j.gde.2023.102087">https://doi.org/10.1016/j.gde.2023.102087</a>.
  ieee: E. Hollwey, A. Briffa, M. Howard, and D. Zilberman, “Concepts, mechanisms
    and implications of long-term epigenetic inheritance,” <i>Current Opinion in Genetics
    and Development</i>, vol. 81, no. 8. Elsevier, 2023.
  ista: Hollwey E, Briffa A, Howard M, Zilberman D. 2023. Concepts, mechanisms and
    implications of long-term epigenetic inheritance. Current Opinion in Genetics
    and Development. 81(8), 102087.
  mla: Hollwey, Elizabeth, et al. “Concepts, Mechanisms and Implications of Long-Term
    Epigenetic Inheritance.” <i>Current Opinion in Genetics and Development</i>, vol.
    81, no. 8, 102087, Elsevier, 2023, doi:<a href="https://doi.org/10.1016/j.gde.2023.102087">10.1016/j.gde.2023.102087</a>.
  short: E. Hollwey, A. Briffa, M. Howard, D. Zilberman, Current Opinion in Genetics
    and Development 81 (2023).
date_created: 2023-08-06T22:01:10Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2023-12-13T12:05:31Z
day: '01'
ddc:
- '570'
department:
- _id: DaZi
doi: 10.1016/j.gde.2023.102087
external_id:
  isi:
  - '001047020200001'
  pmid:
  - '37441873'
file:
- access_level: open_access
  checksum: a294cd9506b80ed6ef218ef44ed32765
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-07T08:32:26Z
  date_updated: 2023-08-07T08:32:26Z
  file_id: '13980'
  file_name: 2023_CurrentOpinionGenetics_Hollwey.pdf
  file_size: 2568632
  relation: main_file
  success: 1
file_date_updated: 2023-08-07T08:32:26Z
has_accepted_license: '1'
intvolume: '        81'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Current Opinion in Genetics and Development
publication_identifier:
  eissn:
  - 1879-0380
  issn:
  - 0959-437X
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Concepts, mechanisms and implications of long-term epigenetic inheritance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2023'
...