---
_id: '9006'
abstract:
- lang: eng
  text: Cytoplasm is a gel-like crowded environment composed of various macromolecules,
    organelles, cytoskeletal networks, and cytosol. The structure of the cytoplasm
    is highly organized and heterogeneous due to the crowding of its constituents
    and their effective compartmentalization. In such an environment, the diffusive
    dynamics of the molecules are restricted, an effect that is further amplified
    by clustering and anchoring of molecules. Despite the crowded nature of the cytoplasm
    at the microscopic scale, large-scale reorganization of the cytoplasm is essential
    for important cellular functions, such as cell division and polarization. How
    such mesoscale reorganization of the cytoplasm is achieved, especially for large
    cells such as oocytes or syncytial tissues that can span hundreds of micrometers
    in size, is only beginning to be understood. In this review, we will discuss recent
    advances in elucidating the molecular, cellular, and biophysical mechanisms by
    which the cytoskeleton drives cytoplasmic reorganization across different scales,
    structures, and species.
acknowledgement: We would like to thank Justine Renno for illustrations and Edouard
  Hannezo and members of the Heisenberg group for their comments on previous versions
  of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Shayan
  full_name: Shamipour, Shayan
  id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
  last_name: Shamipour
- first_name: Silvia
  full_name: Caballero Mancebo, Silvia
  id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
  last_name: Caballero Mancebo
  orcid: 0000-0002-5223-3346
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Shamipour S, Caballero Mancebo S, Heisenberg C-PJ. Cytoplasm’s got moves. <i>Developmental
    Cell</i>. 2021;56(2):P213-226. doi:<a href="https://doi.org/10.1016/j.devcel.2020.12.002">10.1016/j.devcel.2020.12.002</a>
  apa: Shamipour, S., Caballero Mancebo, S., &#38; Heisenberg, C.-P. J. (2021). Cytoplasm’s
    got moves. <i>Developmental Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2020.12.002">https://doi.org/10.1016/j.devcel.2020.12.002</a>
  chicago: Shamipour, Shayan, Silvia Caballero Mancebo, and Carl-Philipp J Heisenberg.
    “Cytoplasm’s Got Moves.” <i>Developmental Cell</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.devcel.2020.12.002">https://doi.org/10.1016/j.devcel.2020.12.002</a>.
  ieee: S. Shamipour, S. Caballero Mancebo, and C.-P. J. Heisenberg, “Cytoplasm’s
    got moves,” <i>Developmental Cell</i>, vol. 56, no. 2. Elsevier, pp. P213-226,
    2021.
  ista: Shamipour S, Caballero Mancebo S, Heisenberg C-PJ. 2021. Cytoplasm’s got moves.
    Developmental Cell. 56(2), P213-226.
  mla: Shamipour, Shayan, et al. “Cytoplasm’s Got Moves.” <i>Developmental Cell</i>,
    vol. 56, no. 2, Elsevier, 2021, pp. P213-226, doi:<a href="https://doi.org/10.1016/j.devcel.2020.12.002">10.1016/j.devcel.2020.12.002</a>.
  short: S. Shamipour, S. Caballero Mancebo, C.-P.J. Heisenberg, Developmental Cell
    56 (2021) P213-226.
date_created: 2021-01-17T23:01:10Z
date_published: 2021-01-25T00:00:00Z
date_updated: 2024-03-25T23:30:10Z
day: '25'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2020.12.002
external_id:
  isi:
  - '000613273900009'
  pmid:
  - '33321104'
intvolume: '        56'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.devcel.2020.12.002
month: '01'
oa: 1
oa_version: Published Version
page: P213-226
pmid: 1
publication: Developmental Cell
publication_identifier:
  eissn:
  - '18781551'
  issn:
  - '15345807'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '9623'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Cytoplasm's got moves
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 56
year: '2021'
...
---
_id: '9294'
abstract:
- lang: eng
  text: In this issue of Developmental Cell, Doyle and colleagues identify periodic
    anterior contraction as a characteristic feature of fibroblasts and mesenchymal
    cancer cells embedded in 3D collagen gels. This contractile mechanism generates
    a matrix prestrain required for crawling in fibrous 3D environments.
article_processing_charge: No
article_type: original
author:
- first_name: Florian R
  full_name: Gärtner, Florian R
  id: 397A88EE-F248-11E8-B48F-1D18A9856A87
  last_name: Gärtner
  orcid: 0000-0001-6120-3723
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Gärtner FR, Sixt MK. Engaging the front wheels to drive through fibrous terrain.
    <i>Developmental Cell</i>. 2021;56(6):723-725. doi:<a href="https://doi.org/10.1016/j.devcel.2021.03.002">10.1016/j.devcel.2021.03.002</a>
  apa: Gärtner, F. R., &#38; Sixt, M. K. (2021). Engaging the front wheels to drive
    through fibrous terrain. <i>Developmental Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2021.03.002">https://doi.org/10.1016/j.devcel.2021.03.002</a>
  chicago: Gärtner, Florian R, and Michael K Sixt. “Engaging the Front Wheels to Drive
    through Fibrous Terrain.” <i>Developmental Cell</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.devcel.2021.03.002">https://doi.org/10.1016/j.devcel.2021.03.002</a>.
  ieee: F. R. Gärtner and M. K. Sixt, “Engaging the front wheels to drive through
    fibrous terrain,” <i>Developmental Cell</i>, vol. 56, no. 6. Elsevier, pp. 723–725,
    2021.
  ista: Gärtner FR, Sixt MK. 2021. Engaging the front wheels to drive through fibrous
    terrain. Developmental Cell. 56(6), 723–725.
  mla: Gärtner, Florian R., and Michael K. Sixt. “Engaging the Front Wheels to Drive
    through Fibrous Terrain.” <i>Developmental Cell</i>, vol. 56, no. 6, Elsevier,
    2021, pp. 723–25, doi:<a href="https://doi.org/10.1016/j.devcel.2021.03.002">10.1016/j.devcel.2021.03.002</a>.
  short: F.R. Gärtner, M.K. Sixt, Developmental Cell 56 (2021) 723–725.
date_created: 2021-03-28T22:01:41Z
date_published: 2021-03-22T00:00:00Z
date_updated: 2023-08-07T14:26:47Z
day: '22'
department:
- _id: MiSi
doi: 10.1016/j.devcel.2021.03.002
external_id:
  isi:
  - '000631681200004'
  pmid:
  - '33756118'
intvolume: '        56'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.devcel.2021.03.002
month: '03'
oa: 1
oa_version: Published Version
page: 723-725
pmid: 1
publication: Developmental Cell
publication_identifier:
  eissn:
  - '18781551'
  issn:
  - '15345807'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Engaging the front wheels to drive through fibrous terrain
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 56
year: '2021'
...
---
_id: '8672'
abstract:
- lang: eng
  text: Cell fate transitions are key to development and homeostasis. It is thus essential
    to understand the cellular mechanisms controlling fate transitions. Cell division
    has been implicated in fate decisions in many stem cell types, including neuronal
    and epithelial progenitors. In other stem cells, such as embryonic stem (ES) cells,
    the role of division remains unclear. Here, we show that exit from naive pluripotency
    in mouse ES cells generally occurs after a division. We further show that exit
    timing is strongly correlated between sister cells, which remain connected by
    cytoplasmic bridges long after division, and that bridge abscission progressively
    accelerates as cells exit naive pluripotency. Finally, interfering with abscission
    impairs naive pluripotency exit, and artificially inducing abscission accelerates
    it. Altogether, our data indicate that a switch in the division machinery leading
    to faster abscission regulates pluripotency exit. Our study identifies abscission
    as a key cellular process coupling cell division to fate transitions.
acknowledgement: This work was supported by the Medical Research Council UK (MRC Program
  award MC_UU_12018/5 ), the European Research Council (starting grant 311637 -MorphoCorDiv
  and consolidator grant 820188 -NanoMechShape to E.K.P.), and the Leverhulme Trust
  (Leverhulme Prize in Biological Sciences to E.K.P.). K.J.C. acknowledges support
  from the Royal Society (Royal Society Research Fellowship). A.C. acknowledges support
  from EMBO ( ALTF 2015-563 ), the Wellcome Trust ( 201334/Z/16/Z ), and the Fondation
  Bettencourt-Schueller (Prix Jeune Chercheur, 2015).
article_processing_charge: No
article_type: original
author:
- first_name: Agathe
  full_name: Chaigne, Agathe
  last_name: Chaigne
- first_name: Céline
  full_name: Labouesse, Céline
  last_name: Labouesse
- first_name: Ian J.
  full_name: White, Ian J.
  last_name: White
- first_name: Meghan
  full_name: Agnew, Meghan
  last_name: Agnew
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Kevin J.
  full_name: Chalut, Kevin J.
  last_name: Chalut
- first_name: Ewa K.
  full_name: Paluch, Ewa K.
  last_name: Paluch
citation:
  ama: Chaigne A, Labouesse C, White IJ, et al. Abscission couples cell division to
    embryonic stem cell fate. <i>Developmental Cell</i>. 2020;55(2):195-208. doi:<a
    href="https://doi.org/10.1016/j.devcel.2020.09.001">10.1016/j.devcel.2020.09.001</a>
  apa: Chaigne, A., Labouesse, C., White, I. J., Agnew, M., Hannezo, E. B., Chalut,
    K. J., &#38; Paluch, E. K. (2020). Abscission couples cell division to embryonic
    stem cell fate. <i>Developmental Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2020.09.001">https://doi.org/10.1016/j.devcel.2020.09.001</a>
  chicago: Chaigne, Agathe, Céline Labouesse, Ian J. White, Meghan Agnew, Edouard
    B Hannezo, Kevin J. Chalut, and Ewa K. Paluch. “Abscission Couples Cell Division
    to Embryonic Stem Cell Fate.” <i>Developmental Cell</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.devcel.2020.09.001">https://doi.org/10.1016/j.devcel.2020.09.001</a>.
  ieee: A. Chaigne <i>et al.</i>, “Abscission couples cell division to embryonic stem
    cell fate,” <i>Developmental Cell</i>, vol. 55, no. 2. Elsevier, pp. 195–208,
    2020.
  ista: Chaigne A, Labouesse C, White IJ, Agnew M, Hannezo EB, Chalut KJ, Paluch EK.
    2020. Abscission couples cell division to embryonic stem cell fate. Developmental
    Cell. 55(2), 195–208.
  mla: Chaigne, Agathe, et al. “Abscission Couples Cell Division to Embryonic Stem
    Cell Fate.” <i>Developmental Cell</i>, vol. 55, no. 2, Elsevier, 2020, pp. 195–208,
    doi:<a href="https://doi.org/10.1016/j.devcel.2020.09.001">10.1016/j.devcel.2020.09.001</a>.
  short: A. Chaigne, C. Labouesse, I.J. White, M. Agnew, E.B. Hannezo, K.J. Chalut,
    E.K. Paluch, Developmental Cell 55 (2020) 195–208.
date_created: 2020-10-18T22:01:37Z
date_published: 2020-10-26T00:00:00Z
date_updated: 2023-08-22T10:16:58Z
day: '26'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.devcel.2020.09.001
external_id:
  isi:
  - '000582501100012'
  pmid:
  - '32979313'
file:
- access_level: open_access
  checksum: 88e1a031a61689165d19a19c2f16d795
  content_type: application/pdf
  creator: dernst
  date_created: 2021-02-04T10:20:02Z
  date_updated: 2021-02-04T10:20:02Z
  file_id: '9086'
  file_name: 2020_DevelopmCell_Chaigne.pdf
  file_size: 6929686
  relation: main_file
  success: 1
file_date_updated: 2021-02-04T10:20:02Z
has_accepted_license: '1'
intvolume: '        55'
isi: 1
issue: '2'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 195-208
pmid: 1
publication: Developmental Cell
publication_identifier:
  eissn:
  - '18781551'
  issn:
  - '15345807'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Abscission couples cell division to embryonic stem cell fate
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 55
year: '2020'
...
---
_id: '8957'
abstract:
- lang: eng
  text: Global tissue tension anisotropy has been shown to trigger stereotypical cell
    division orientation by elongating mitotic cells along the main tension axis.
    Yet, how tissue tension elongates mitotic cells despite those cells undergoing
    mitotic rounding (MR) by globally upregulating cortical actomyosin tension remains
    unclear. We addressed this question by taking advantage of ascidian embryos, consisting
    of a small number of interphasic and mitotic blastomeres and displaying an invariant
    division pattern. We found that blastomeres undergo MR by locally relaxing cortical
    tension at their apex, thereby allowing extrinsic pulling forces from neighboring
    interphasic blastomeres to polarize their shape and thus division orientation.
    Consistently, interfering with extrinsic forces by reducing the contractility
    of interphasic blastomeres or disrupting the establishment of asynchronous mitotic
    domains leads to aberrant mitotic cell division orientations. Thus, apical relaxation
    during MR constitutes a key mechanism by which tissue tension anisotropy controls
    stereotypical cell division orientation.
acknowledged_ssus:
- _id: Bio
- _id: NanoFab
acknowledgement: 'We thank members of the Heisenberg and McDougall groups for technical
  advice and discussion, Hitoyoshi Yasuo for sharing lab equipment, Lucas Leclère
  and Hitoyoshi Yasuo for their comments on a preliminary version of the manuscript,
  and Philippe Dru for the Rose plots. We are grateful to the Bioimaging and Nanofabrication
  facilities of IST Austria and the Imaging Platform (PIM) and animal facility (CRB)
  of Institut de la Mer de Villefranche (IMEV), which is supported by EMBRC-France,
  whose French state funds are managed by the ANR within the Investments of the Future
  program under reference ANR-10-INBS-0, for continuous support. This work was supported
  by a grant from the French Government funding agency Agence National de la Recherche
  (ANR “MorCell”: ANR-17-CE 13-002 8).'
article_processing_charge: No
article_type: original
author:
- first_name: Benoit G
  full_name: Godard, Benoit G
  id: 33280250-F248-11E8-B48F-1D18A9856A87
  last_name: Godard
- first_name: Rémi
  full_name: Dumollard, Rémi
  last_name: Dumollard
- first_name: Edwin
  full_name: Munro, Edwin
  last_name: Munro
- first_name: Janet
  full_name: Chenevert, Janet
  last_name: Chenevert
- first_name: Céline
  full_name: Hebras, Céline
  last_name: Hebras
- first_name: Alex
  full_name: Mcdougall, Alex
  last_name: Mcdougall
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Godard BG, Dumollard R, Munro E, et al. Apical relaxation during mitotic rounding
    promotes tension-oriented cell division. <i>Developmental Cell</i>. 2020;55(6):695-706.
    doi:<a href="https://doi.org/10.1016/j.devcel.2020.10.016">10.1016/j.devcel.2020.10.016</a>
  apa: Godard, B. G., Dumollard, R., Munro, E., Chenevert, J., Hebras, C., Mcdougall,
    A., &#38; Heisenberg, C.-P. J. (2020). Apical relaxation during mitotic rounding
    promotes tension-oriented cell division. <i>Developmental Cell</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.devcel.2020.10.016">https://doi.org/10.1016/j.devcel.2020.10.016</a>
  chicago: Godard, Benoit G, Rémi Dumollard, Edwin Munro, Janet Chenevert, Céline
    Hebras, Alex Mcdougall, and Carl-Philipp J Heisenberg. “Apical Relaxation during
    Mitotic Rounding Promotes Tension-Oriented Cell Division.” <i>Developmental Cell</i>.
    Elsevier, 2020. <a href="https://doi.org/10.1016/j.devcel.2020.10.016">https://doi.org/10.1016/j.devcel.2020.10.016</a>.
  ieee: B. G. Godard <i>et al.</i>, “Apical relaxation during mitotic rounding promotes
    tension-oriented cell division,” <i>Developmental Cell</i>, vol. 55, no. 6. Elsevier,
    pp. 695–706, 2020.
  ista: Godard BG, Dumollard R, Munro E, Chenevert J, Hebras C, Mcdougall A, Heisenberg
    C-PJ. 2020. Apical relaxation during mitotic rounding promotes tension-oriented
    cell division. Developmental Cell. 55(6), 695–706.
  mla: Godard, Benoit G., et al. “Apical Relaxation during Mitotic Rounding Promotes
    Tension-Oriented Cell Division.” <i>Developmental Cell</i>, vol. 55, no. 6, Elsevier,
    2020, pp. 695–706, doi:<a href="https://doi.org/10.1016/j.devcel.2020.10.016">10.1016/j.devcel.2020.10.016</a>.
  short: B.G. Godard, R. Dumollard, E. Munro, J. Chenevert, C. Hebras, A. Mcdougall,
    C.-P.J. Heisenberg, Developmental Cell 55 (2020) 695–706.
date_created: 2020-12-20T23:01:19Z
date_published: 2020-12-21T00:00:00Z
date_updated: 2023-08-24T11:01:22Z
day: '21'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2020.10.016
external_id:
  isi:
  - '000600665700008'
  pmid:
  - '33207225'
intvolume: '        55'
isi: 1
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 695-706
pmid: 1
publication: Developmental Cell
publication_identifier:
  eissn:
  - '18781551'
  issn:
  - '15345807'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/relaxing-cell-divisions/
scopus_import: '1'
status: public
title: Apical relaxation during mitotic rounding promotes tension-oriented cell division
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 55
year: '2020'
...