@article{14039,
  abstract     = {Membranes are essential for life. They act as semi-permeable boundaries that define cells and organelles. In addition, their surfaces actively participate in biochemical reaction networks, where they confine proteins, align reaction partners, and directly control enzymatic activities. Membrane-localized reactions shape cellular membranes, define the identity of organelles, compartmentalize biochemical processes, and can even be the source of signaling gradients that originate at the plasma membrane and reach into the cytoplasm and nucleus. The membrane surface is, therefore, an essential platform upon which myriad cellular processes are scaffolded. In this review, we summarize our current understanding of the biophysics and biochemistry of membrane-localized reactions with particular focus on insights derived from reconstituted and cellular systems. We discuss how the interplay of cellular factors results in their self-organization, condensation, assembly, and activity, and the emergent properties derived from them.},
  author       = {Leonard, Thomas A. and Loose, Martin and Martens, Sascha},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {15},
  pages        = {1315--1332},
  publisher    = {Elsevier},
  title        = {{The membrane surface as a platform that organizes cellular and biochemical processes}},
  doi          = {10.1016/j.devcel.2023.06.001},
  volume       = {58},
  year         = {2023},
}

@article{12830,
  abstract     = {Interstitial fluid (IF) accumulation between embryonic cells is thought to be important for embryo patterning and morphogenesis. Here, we identify a positive mechanical feedback loop between cell migration and IF relocalization and find that it promotes embryonic axis formation during zebrafish gastrulation. We show that anterior axial mesendoderm (prechordal plate [ppl]) cells, moving in between the yolk cell and deep cell tissue to extend the embryonic axis, compress the overlying deep cell layer, thereby causing IF to flow from the deep cell layer to the boundary between the yolk cell and the deep cell layer, directly ahead of the advancing ppl. This IF relocalization, in turn, facilitates ppl cell protrusion formation and migration by opening up the space into which the ppl moves and, thereby, the ability of the ppl to trigger IF relocalization by pushing against the overlying deep cell layer. Thus, embryonic axis formation relies on a hydraulic feedback loop between cell migration and IF relocalization.},
  author       = {Huljev, Karla and Shamipour, Shayan and Nunes Pinheiro, Diana C and Preusser, Friedrich and Steccari, Irene and Sommer, Christoph M and Naik, Suyash and Heisenberg, Carl-Philipp J},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {7},
  pages        = {582--596.e7},
  publisher    = {Elsevier},
  title        = {{A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish}},
  doi          = {10.1016/j.devcel.2023.02.016},
  volume       = {58},
  year         = {2023},
}

@article{10703,
  abstract     = {When crawling through the body, leukocytes often traverse tissues that are densely packed with extracellular matrix and other cells, and this raises the question: How do leukocytes overcome compressive mechanical loads? Here, we show that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness requires neither force sensing via the nucleus nor adhesive interactions with a substrate. Upon global compression of the cell body as well as local indentation of the plasma membrane, Wiskott-Aldrich syndrome protein (WASp) assembles into dot-like structures, providing activation platforms for Arp2/3 nucleated actin patches. These patches locally push against the external load, which can be obstructing collagen fibers or other cells, and thereby create space to facilitate forward locomotion. We show in vitro and in vivo that this WASp function is rate limiting for ameboid leukocyte migration in dense but not in loose environments and is required for trafficking through diverse tissues such as skin and lymph nodes.},
  author       = {Gaertner, Florian and Reis-Rodrigues, Patricia and De Vries, Ingrid and Hons, Miroslav and Aguilera, Juan and Riedl, Michael and Leithner, Alexander F and Tasciyan, Saren and Kopf, Aglaja and Merrin, Jack and Zheden, Vanessa and Kaufmann, Walter and Hauschild, Robert and Sixt, Michael K},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {1},
  pages        = {47--62.e9},
  publisher    = {Cell Press ; Elsevier},
  title        = {{WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues}},
  doi          = {10.1016/j.devcel.2021.11.024},
  volume       = {57},
  year         = {2022},
}

@article{10714,
  abstract     = {Ribosomal defects perturb stem cell differentiation, causing diseases called ribosomopathies. How ribosome levels control stem cell differentiation is not fully known. Here, we discovered three RNA helicases are required for ribosome biogenesis and for Drosophila oogenesis. Loss of these helicases, which we named Aramis, Athos and Porthos, lead to aberrant stabilization of p53, cell cycle arrest and stalled GSC differentiation. Unexpectedly, Aramis is required for efficient translation of a cohort of mRNAs containing a 5’-Terminal-Oligo-Pyrimidine (TOP)-motif, including mRNAs that encode ribosomal proteins and a conserved p53 inhibitor, Novel Nucleolar protein 1 (Non1). The TOP-motif co-regulates the translation of growth-related mRNAs in mammals. As in mammals, the La-related protein co-regulates the translation of TOP-motif containing RNAs during Drosophila oogenesis. Thus, a previously unappreciated TOP-motif in Drosophila responds to reduced ribosome biogenesis to co-regulate the translation of ribosomal proteins and a p53 repressor, thus coupling ribosome biogenesis to GSC differentiation.},
  author       = {Martin, Elliot T. and Blatt, Patrick and Ngyuen, Elaine and Lahr, Roni and Selvam, Sangeetha and Yoon, Hyun Ah M. and Pocchiari, Tyler and Emtenani, Shamsi and Siekhaus, Daria E and Berman, Andrea and Fuchs, Gabriele and Rangan, Prashanth},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {7},
  pages        = {883--900.e10},
  publisher    = {Elsevier},
  title        = {{A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis}},
  doi          = {10.1016/j.devcel.2022.03.005},
  volume       = {57},
  year         = {2022},
}

@article{11968,
  abstract     = {Membrane phospholipids typically contain fatty acids (FAs) of 16 and 18 carbon atoms. This particular chain length is evolutionarily highly conserved and presumably provides maximum stability and dynamic properties to biological membranes in response to nutritional or environmental cues. Here, we show that the relative proportion of C16 versus C18 FAs is regulated by the activity of acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme of FA de novo synthesis. Acc1 activity is attenuated by AMPK/Snf1-dependent phosphorylation, which is required to maintain an appropriate acyl-chain length distribution. Moreover, we find that the transcriptional repressor Opi1 preferentially binds to C16 over C18 phosphatidic acid (PA) species: thus, C16-chain containing PA sequesters Opi1 more effectively to the ER, enabling AMPK/Snf1 control of PA acyl-chain length to determine the degree of derepression of Opi1 target genes. These findings reveal an unexpected regulatory link between the major energy-sensing kinase, membrane lipid composition, and transcription.},
  author       = {Hofbauer, Harald F. and Schopf, Florian H. and Schleifer, Hannes and Knittelfelder, Oskar L. and Pieber, Bartholomäus and Rechberger, Gerald N. and Wolinski, Heimo and Gaspar, Maria L. and Kappe, C. Oliver and Stadlmann, Johannes and Mechtler, Karl and Zenz, Alexandra and Lohner, Karl and Tehlivets, Oksana and Henry, Susan A. and Kohlwein, Sepp D.},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {6},
  pages        = {P729--739},
  publisher    = {Elsevier},
  title        = {{Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids}},
  doi          = {10.1016/j.devcel.2014.04.025},
  volume       = {29},
  year         = {2014},
}

@article{9520,
  abstract     = {Plants undergo alternation of generation in which reproductive cells develop in the plant body ("sporophytic generation") and then differentiate into a multicellular gamete-forming "gametophytic generation." Different populations of helper cells assist in this transgenerational journey, with somatic tissues supporting early development and single nurse cells supporting gametogenesis. New data reveal a two-way relationship between early reproductive cells and their helpers involving complex epigenetic and signaling networks determining cell number and fate. Later, the egg cell plays a central role in specifying accessory cells, whereas in both gametophytes, companion cells contribute non-cell-autonomously to the epigenetic landscape of the gamete genomes.},
  author       = {Feng, Xiaoqi and Zilberman, Daniel and Dickinson, Hugh},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {3},
  pages        = {215--225},
  publisher    = {Elsevier},
  title        = {{A conversation across generations: Soma-germ cell crosstalk in plants}},
  doi          = {10.1016/j.devcel.2013.01.014},
  volume       = {24},
  year         = {2013},
}

@misc{9522,
  abstract     = {Little is known about chromatin remodeling events immediately after fertilization. A recent report by Autran et al. (2011) in Cell now shows that chromatin regulatory pathways that silence transposable elements are responsible for global delayed activation of gene expression in the early Arabidopsis embryo.},
  author       = {Zilberman, Daniel},
  booktitle    = {Developmental Cell},
  issn         = {1878-1551},
  number       = {6},
  pages        = {735--736},
  publisher    = {Elsevier},
  title        = {{Balancing parental contributions in plant embryonic gene activation}},
  doi          = {10.1016/j.devcel.2011.05.018},
  volume       = {20},
  year         = {2011},
}

@article{4168,
  abstract     = {Recent studies show that signaling through integrin receptors is required for normal cell movements during Xenopus gastrulation. Integrins function in this process by modulating the activity of cadherin adhesion molecules within tissues undergoing convergence and extension movements.},
  author       = {Montero, Juan and Heisenberg, Carl-Philipp J},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {2},
  pages        = {190 -- 191},
  publisher    = {Cell Press},
  title        = {{Adhesive crosstalk in gastrulation}},
  doi          = {10.1016/S1534-5807(03)00235-1},
  volume       = {5},
  year         = {2003},
}