---
_id: '7883'
abstract:
- lang: eng
  text: All vertebrates have a spinal cord with dimensions and shape specific to their
    species. Yet how species‐specific organ size and shape are achieved is a fundamental
    unresolved question in biology. The formation and sculpting of organs begins during
    embryonic development. As it develops, the spinal cord extends in anterior–posterior
    direction in synchrony with the overall growth of the body. The dorsoventral (DV)
    and apicobasal lengths of the spinal cord neuroepithelium also change, while at
    the same time a characteristic pattern of neural progenitor subtypes along the
    DV axis is established and elaborated. At the basis of these changes in tissue
    size and shape are biophysical determinants, such as the change in cell number,
    cell size and shape, and anisotropic tissue growth. These processes are controlled
    by global tissue‐scale regulators, such as morphogen signaling gradients as well
    as mechanical forces. Current challenges in the field are to uncover how these
    tissue‐scale regulatory mechanisms are translated to the cellular and molecular
    level, and how regulation of distinct cellular processes gives rise to an overall
    defined size. Addressing these questions will help not only to achieve a better
    understanding of how size is controlled, but also of how tissue size is coordinated
    with the specification of pattern.
acknowledgement: 'Austrian Academy of Sciences, Grant/Award Number: DOC fellowship
  for Katarzyna Kuzmicz-Kowalska; Austrian Science Fund, Grant/Award Number: F78 (Stem
  Cell Modulation); H2020 European Research Council, Grant/Award Number: 680037'
article_number: e383
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Katarzyna
  full_name: Kuzmicz-Kowalska, Katarzyna
  id: 4CED352A-F248-11E8-B48F-1D18A9856A87
  last_name: Kuzmicz-Kowalska
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
citation:
  ama: 'Kuzmicz-Kowalska K, Kicheva A. Regulation of size and scale in vertebrate
    spinal cord development. <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>.
    2021. doi:<a href="https://doi.org/10.1002/wdev.383">10.1002/wdev.383</a>'
  apa: 'Kuzmicz-Kowalska, K., &#38; Kicheva, A. (2021). Regulation of size and scale
    in vertebrate spinal cord development. <i>Wiley Interdisciplinary Reviews: Developmental
    Biology</i>. Wiley. <a href="https://doi.org/10.1002/wdev.383">https://doi.org/10.1002/wdev.383</a>'
  chicago: 'Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and
    Scale in Vertebrate Spinal Cord Development.” <i>Wiley Interdisciplinary Reviews:
    Developmental Biology</i>. Wiley, 2021. <a href="https://doi.org/10.1002/wdev.383">https://doi.org/10.1002/wdev.383</a>.'
  ieee: 'K. Kuzmicz-Kowalska and A. Kicheva, “Regulation of size and scale in vertebrate
    spinal cord development,” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>.
    Wiley, 2021.'
  ista: 'Kuzmicz-Kowalska K, Kicheva A. 2021. Regulation of size and scale in vertebrate
    spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology.,
    e383.'
  mla: 'Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale
    in Vertebrate Spinal Cord Development.” <i>Wiley Interdisciplinary Reviews: Developmental
    Biology</i>, e383, Wiley, 2021, doi:<a href="https://doi.org/10.1002/wdev.383">10.1002/wdev.383</a>.'
  short: 'K. Kuzmicz-Kowalska, A. Kicheva, Wiley Interdisciplinary Reviews: Developmental
    Biology (2021).'
date_created: 2020-05-24T22:01:00Z
date_published: 2021-04-15T00:00:00Z
date_updated: 2024-03-07T15:03:00Z
day: '15'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1002/wdev.383
ec_funded: 1
external_id:
  isi:
  - '000531419400001'
  pmid:
  - '32391980'
file:
- access_level: open_access
  checksum: f0a7745d48afa09ea7025e876a0145a8
  content_type: application/pdf
  creator: dernst
  date_created: 2020-11-24T13:11:39Z
  date_updated: 2020-11-24T13:11:39Z
  file_id: '8800'
  file_name: 2020_WIREs_DevBio_KuzmiczKowalska.pdf
  file_size: 2527276
  relation: main_file
  success: 1
file_date_updated: 2020-11-24T13:11:39Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 267AF0E4-B435-11E9-9278-68D0E5697425
  name: The role of morphogens in the regulation of neural tube growth
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
  grant_number: F07802
  name: Morphogen control of growth and pattern in the spinal cord
publication: 'Wiley Interdisciplinary Reviews: Developmental Biology'
publication_identifier:
  eissn:
  - '17597692'
  issn:
  - '17597684'
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '14323'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Regulation of size and scale in vertebrate spinal cord development
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2021'
...