---
_id: '10361'
abstract:
- lang: eng
  text: Understanding how normally soluble peptides and proteins aggregate to form
    amyloid fibrils is central to many areas of modern biomolecular science, ranging
    from the development of functional biomaterials to the design of rational therapeutic
    strategies against increasingly prevalent medical conditions such as Alzheimer's
    and Parkinson's diseases. As such, there is a great need to develop models to
    mechanistically describe how amyloid fibrils are formed from precursor peptides
    and proteins. Here we review and discuss how ideas and concepts from chemical
    reaction kinetics can help to achieve this objective. In particular, we show how
    a combination of theory, experiments, and computer simulations, based on chemical
    kinetics, provides a general formalism for uncovering, at the molecular level,
    the mechanistic steps that underlie the phenomenon of amyloid fibril formation.
acknowledgement: "We acknowledge support from the Swiss National Science Foundation
  (T.C.T.M.); Peterhouse,\r\nCambridge (T.C.T.M.); the Royal Society (A.S.); the Academy
  of Medical Sciences (A.S.); the\r\nWellcome Trust (A.S., M.V., C.M.D., T.P.J.K.);
  the Cambridge Centre for Misfolding Diseases\r\n(M.V., C.M.D., T.P.J.K.); the Biotechnology
  and Biological Sciences Research Council (C.M.D.,\r\nT.P.J.K.); and the Frances
  and Augustus Newman Foundation (T.P.J.K.). The research leading\r\nto these results
  has received funding from the European Research Council (ERC) under the\r\nEuropean
  Union’s Seventh Framework Programme (FP7/2007-2013) through the ERC grant\r\nPhysProt
  (337969)."
article_processing_charge: No
article_type: original
author:
- first_name: Thomas C.T.
  full_name: Michaels, Thomas C.T.
  last_name: Michaels
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Johnny
  full_name: Habchi, Johnny
  last_name: Habchi
- first_name: Sean
  full_name: Chia, Sean
  last_name: Chia
- first_name: Georg
  full_name: Meisl, Georg
  last_name: Meisl
- first_name: Michele
  full_name: Vendruscolo, Michele
  last_name: Vendruscolo
- first_name: Christopher M.
  full_name: Dobson, Christopher M.
  last_name: Dobson
- first_name: Tuomas P.J.
  full_name: Knowles, Tuomas P.J.
  last_name: Knowles
citation:
  ama: Michaels TCT, Šarić A, Habchi J, et al. Chemical kinetics for bridging molecular
    mechanisms and macroscopic measurements of amyloid fibril formation. <i>Annual
    Review of Physical Chemistry</i>. 2018;69(1):273-298. doi:<a href="https://doi.org/10.1146/annurev-physchem-050317-021322">10.1146/annurev-physchem-050317-021322</a>
  apa: Michaels, T. C. T., Šarić, A., Habchi, J., Chia, S., Meisl, G., Vendruscolo,
    M., … Knowles, T. P. J. (2018). Chemical kinetics for bridging molecular mechanisms
    and macroscopic measurements of amyloid fibril formation. <i>Annual Review of
    Physical Chemistry</i>. Annual Reviews. <a href="https://doi.org/10.1146/annurev-physchem-050317-021322">https://doi.org/10.1146/annurev-physchem-050317-021322</a>
  chicago: Michaels, Thomas C.T., Anđela Šarić, Johnny Habchi, Sean Chia, Georg Meisl,
    Michele Vendruscolo, Christopher M. Dobson, and Tuomas P.J. Knowles. “Chemical
    Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid
    Fibril Formation.” <i>Annual Review of Physical Chemistry</i>. Annual Reviews,
    2018. <a href="https://doi.org/10.1146/annurev-physchem-050317-021322">https://doi.org/10.1146/annurev-physchem-050317-021322</a>.
  ieee: T. C. T. Michaels <i>et al.</i>, “Chemical kinetics for bridging molecular
    mechanisms and macroscopic measurements of amyloid fibril formation,” <i>Annual
    Review of Physical Chemistry</i>, vol. 69, no. 1. Annual Reviews, pp. 273–298,
    2018.
  ista: Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM,
    Knowles TPJ. 2018. Chemical kinetics for bridging molecular mechanisms and macroscopic
    measurements of amyloid fibril formation. Annual Review of Physical Chemistry.
    69(1), 273–298.
  mla: Michaels, Thomas C. T., et al. “Chemical Kinetics for Bridging Molecular Mechanisms
    and Macroscopic Measurements of Amyloid Fibril Formation.” <i>Annual Review of
    Physical Chemistry</i>, vol. 69, no. 1, Annual Reviews, 2018, pp. 273–98, doi:<a
    href="https://doi.org/10.1146/annurev-physchem-050317-021322">10.1146/annurev-physchem-050317-021322</a>.
  short: T.C.T. Michaels, A. Šarić, J. Habchi, S. Chia, G. Meisl, M. Vendruscolo,
    C.M. Dobson, T.P.J. Knowles, Annual Review of Physical Chemistry 69 (2018) 273–298.
date_created: 2021-11-26T12:52:12Z
date_published: 2018-02-28T00:00:00Z
date_updated: 2021-11-26T15:58:19Z
day: '28'
doi: 10.1146/annurev-physchem-050317-021322
extern: '1'
external_id:
  pmid:
  - '29490200'
intvolume: '        69'
issue: '1'
keyword:
- physical and theoretical chemistry
language:
- iso: eng
month: '02'
oa_version: None
page: 273-298
pmid: 1
publication: Annual Review of Physical Chemistry
publication_identifier:
  eissn:
  - 1545-1593
  issn:
  - 0066-426X
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chemical kinetics for bridging molecular mechanisms and macroscopic measurements
  of amyloid fibril formation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 69
year: '2018'
...