---
_id: '12115'
acknowledgement: This work was supported by European Commission’s Seventh Framework
  Programme under Grant Agreement No. 279113 (OCTIPS; www.octips.eu).
article_processing_charge: No
article_type: original
author:
- first_name: Jacek
  full_name: Glajzer, Jacek
  last_name: Glajzer
- first_name: Dan Cacsire
  full_name: Castillo-Tong, Dan Cacsire
  last_name: Castillo-Tong
- first_name: Rolf
  full_name: Richter, Rolf
  last_name: Richter
- first_name: Ignace
  full_name: Vergote, Ignace
  last_name: Vergote
- first_name: Hagen
  full_name: Kulbe, Hagen
  last_name: Kulbe
- first_name: Adriaan
  full_name: Vanderstichele, Adriaan
  last_name: Vanderstichele
- first_name: Ilary
  full_name: Ruscito, Ilary
  last_name: Ruscito
- first_name: Fabian
  full_name: Trillsch, Fabian
  last_name: Trillsch
- first_name: Alexander
  full_name: Mustea, Alexander
  last_name: Mustea
- first_name: Caroline
  full_name: Kreuzinger, Caroline
  id: 382077BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kreuzinger
- first_name: Charlie
  full_name: Gourley, Charlie
  last_name: Gourley
- first_name: Hani
  full_name: Gabra, Hani
  last_name: Gabra
- first_name: Eliane T.
  full_name: Taube, Eliane T.
  last_name: Taube
- first_name: Oliver
  full_name: Dorigo, Oliver
  last_name: Dorigo
- first_name: David
  full_name: Horst, David
  last_name: Horst
- first_name: Carlotta
  full_name: Keunecke, Carlotta
  last_name: Keunecke
- first_name: Joanna
  full_name: Baum, Joanna
  last_name: Baum
- first_name: Timothy
  full_name: Angelotti, Timothy
  last_name: Angelotti
- first_name: Jalid
  full_name: Sehouli, Jalid
  last_name: Sehouli
- first_name: Elena Ioana
  full_name: Braicu, Elena Ioana
  last_name: Braicu
citation:
  ama: 'Glajzer J, Castillo-Tong DC, Richter R, et al. ASO Visual Abstract: Impact
    of BRCA mutation status on tumor dissemination pattern, surgical outcome, and
    patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC).
    A multicenter, retrospective study of the ovarian cancer therapy—innovative models
    prolong survival (OCTIPS) consortium. <i>Annals of Surgical Oncology</i>. 2023;30:46-47.
    doi:<a href="https://doi.org/10.1245/s10434-022-12681-z">10.1245/s10434-022-12681-z</a>'
  apa: 'Glajzer, J., Castillo-Tong, D. C., Richter, R., Vergote, I., Kulbe, H., Vanderstichele,
    A., … Braicu, E. I. (2023). ASO Visual Abstract: Impact of BRCA mutation status
    on tumor dissemination pattern, surgical outcome, and patient survival in primary
    and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective
    study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS)
    consortium. <i>Annals of Surgical Oncology</i>. Springer Nature. <a href="https://doi.org/10.1245/s10434-022-12681-z">https://doi.org/10.1245/s10434-022-12681-z</a>'
  chicago: 'Glajzer, Jacek, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote,
    Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, et al. “ASO Visual Abstract:
    Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome,
    and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer
    (HGSOC). A Multicenter, Retrospective Study of the Ovarian Cancer Therapy—Innovative
    Models Prolong Survival (OCTIPS) Consortium.” <i>Annals of Surgical Oncology</i>.
    Springer Nature, 2023. <a href="https://doi.org/10.1245/s10434-022-12681-z">https://doi.org/10.1245/s10434-022-12681-z</a>.'
  ieee: 'J. Glajzer <i>et al.</i>, “ASO Visual Abstract: Impact of BRCA mutation status
    on tumor dissemination pattern, surgical outcome, and patient survival in primary
    and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective
    study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS)
    consortium,” <i>Annals of Surgical Oncology</i>, vol. 30. Springer Nature, pp.
    46–47, 2023.'
  ista: 'Glajzer J, Castillo-Tong DC, Richter R, Vergote I, Kulbe H, Vanderstichele
    A, Ruscito I, Trillsch F, Mustea A, Kreuzinger C, Gourley C, Gabra H, Taube ET,
    Dorigo O, Horst D, Keunecke C, Baum J, Angelotti T, Sehouli J, Braicu EI. 2023.
    ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern,
    surgical outcome, and patient survival in primary and recurrent high-grade serous
    ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer
    therapy—innovative models prolong survival (OCTIPS) consortium. Annals of Surgical
    Oncology. 30, 46–47.'
  mla: 'Glajzer, Jacek, et al. “ASO Visual Abstract: Impact of BRCA Mutation Status
    on Tumor Dissemination Pattern, Surgical Outcome, and Patient Survival in Primary
    and Recurrent High-Grade Serous Ovarian Cancer (HGSOC). A Multicenter, Retrospective
    Study of the Ovarian Cancer Therapy—Innovative Models Prolong Survival (OCTIPS)
    Consortium.” <i>Annals of Surgical Oncology</i>, vol. 30, Springer Nature, 2023,
    pp. 46–47, doi:<a href="https://doi.org/10.1245/s10434-022-12681-z">10.1245/s10434-022-12681-z</a>.'
  short: J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele,
    I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T.
    Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I.
    Braicu, Annals of Surgical Oncology 30 (2023) 46–47.
date_created: 2023-01-12T11:56:22Z
date_published: 2023-01-01T00:00:00Z
date_updated: 2023-09-05T15:18:36Z
day: '01'
department:
- _id: JoDa
doi: 10.1245/s10434-022-12681-z
external_id:
  isi:
  - '000879151800001'
intvolume: '        30'
isi: 1
keyword:
- Oncology
- Surgery
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1245/s10434-022-12681-z
month: '01'
oa: 1
oa_version: Published Version
page: 46-47
publication: Annals of Surgical Oncology
publication_identifier:
  eissn:
  - 1534-4681
  issn:
  - 1068-9265
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '12205'
    relation: other
    status: public
scopus_import: '1'
status: public
title: 'ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination
  pattern, surgical outcome, and patient survival in primary and recurrent high-grade
  serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian
  cancer therapy—innovative models prolong survival (OCTIPS) consortium'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 30
year: '2023'
...
---
_id: '12205'
abstract:
- lang: eng
  text: "Background: This study seeks to evaluate the impact of breast cancer (BRCA)
    gene status on tumor dissemination pattern, surgical outcome and survival in a
    multicenter cohort of paired primary ovarian cancer (pOC) and recurrent ovarian
    cancer (rOC).\r\n\r\nPatients and Methods: Medical records and follow-up data
    from 190 patients were gathered retrospectively. All patients had surgery at pOC
    and at least one further rOC surgery at four European high-volume centers. Patients
    were divided into one cohort with confirmed mutation for BRCA1 and/or BRCA2 (BRCAmut)
    and a second cohort with BRCA wild type or unknown (BRCAwt). Patterns of tumor
    presentation, surgical outcome and survival data were analyzed between the two
    groups.\r\n\r\nResults: Patients with BRCAmut disease were on average 4 years
    younger and had significantly more tumor involvement upon diagnosis. Patients
    with BRCAmut disease showed higher debulking rates at all stages. Multivariate
    analysis showed that only patient age had significant predictive value for complete
    tumor resection in pOC. At rOC, however, only BRCAmut status significantly correlated
    with optimal debulking. Patients with BRCAmut disease showed significantly prolonged
    overall survival (OS) by 24.3 months. Progression-free survival (PFS) was prolonged
    in the BRCAmut group at all stages as well, reaching statistical significance
    during recurrence.\r\n\r\nConclusions: Patients with BRCAmut disease showed a
    more aggressive course of disease with earlier onset and more extensive tumor
    dissemination at pOC. However, surgical outcome and OS were significantly better
    in patients with BRCAmut disease compared with patients with BRCAwt disease. We
    therefore propose to consider BRCAmut status in regard to patient selection for
    cytoreductive surgery, especially in rOC."
acknowledgement: "E.I.B. is a Feodor Lynen fellow of the Humboldt Foundation and a
  participant of the Charité Clinical Scientist Program funded by the Charité Universitätsmedizin
  Berlin and the Berlin Institute of Health. This work was supported by European Commission’s
  Seventh Framework Programme under grant agreement no. 279113 (OCTIPS; www.octips.eu).\r\nOpen
  Access funding enabled and organized by Projekt DEAL."
article_processing_charge: No
article_type: original
author:
- first_name: Jacek
  full_name: Glajzer, Jacek
  last_name: Glajzer
- first_name: Dan Cacsire
  full_name: Castillo-Tong, Dan Cacsire
  last_name: Castillo-Tong
- first_name: Rolf
  full_name: Richter, Rolf
  last_name: Richter
- first_name: Ignace
  full_name: Vergote, Ignace
  last_name: Vergote
- first_name: Hagen
  full_name: Kulbe, Hagen
  last_name: Kulbe
- first_name: Adriaan
  full_name: Vanderstichele, Adriaan
  last_name: Vanderstichele
- first_name: Ilary
  full_name: Ruscito, Ilary
  last_name: Ruscito
- first_name: Fabian
  full_name: Trillsch, Fabian
  last_name: Trillsch
- first_name: Alexander
  full_name: Mustea, Alexander
  last_name: Mustea
- first_name: Caroline
  full_name: Kreuzinger, Caroline
  id: 382077BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kreuzinger
- first_name: Charlie
  full_name: Gourley, Charlie
  last_name: Gourley
- first_name: Hani
  full_name: Gabra, Hani
  last_name: Gabra
- first_name: Eliane T.
  full_name: Taube, Eliane T.
  last_name: Taube
- first_name: Oliver
  full_name: Dorigo, Oliver
  last_name: Dorigo
- first_name: David
  full_name: Horst, David
  last_name: Horst
- first_name: Carlotta
  full_name: Keunecke, Carlotta
  last_name: Keunecke
- first_name: Joanna
  full_name: Baum, Joanna
  last_name: Baum
- first_name: Timothy
  full_name: Angelotti, Timothy
  last_name: Angelotti
- first_name: Jalid
  full_name: Sehouli, Jalid
  last_name: Sehouli
- first_name: Elena Ioana
  full_name: Braicu, Elena Ioana
  last_name: Braicu
citation:
  ama: 'Glajzer J, Castillo-Tong DC, Richter R, et al. Impact of BRCA mutation status
    on tumor dissemination pattern, surgical outcome and patient survival in primary
    and recurrent high-grade serous ovarian cancer: A multicenter retrospective study
    by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium.
    <i>Annals of Surgical Oncology</i>. 2023;30:35-45. doi:<a href="https://doi.org/10.1245/s10434-022-12459-3">10.1245/s10434-022-12459-3</a>'
  apa: 'Glajzer, J., Castillo-Tong, D. C., Richter, R., Vergote, I., Kulbe, H., Vanderstichele,
    A., … Braicu, E. I. (2023). Impact of BRCA mutation status on tumor dissemination
    pattern, surgical outcome and patient survival in primary and recurrent high-grade
    serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer
    Therapy-Innovative Models Prolong Survival (OCTIPS) consortium. <i>Annals of Surgical
    Oncology</i>. Springer Nature. <a href="https://doi.org/10.1245/s10434-022-12459-3">https://doi.org/10.1245/s10434-022-12459-3</a>'
  chicago: 'Glajzer, Jacek, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote,
    Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, et al. “Impact of BRCA Mutation
    Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in
    Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective
    Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium.”
    <i>Annals of Surgical Oncology</i>. Springer Nature, 2023. <a href="https://doi.org/10.1245/s10434-022-12459-3">https://doi.org/10.1245/s10434-022-12459-3</a>.'
  ieee: 'J. Glajzer <i>et al.</i>, “Impact of BRCA mutation status on tumor dissemination
    pattern, surgical outcome and patient survival in primary and recurrent high-grade
    serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer
    Therapy-Innovative Models Prolong Survival (OCTIPS) consortium,” <i>Annals of
    Surgical Oncology</i>, vol. 30. Springer Nature, pp. 35–45, 2023.'
  ista: 'Glajzer J, Castillo-Tong DC, Richter R, Vergote I, Kulbe H, Vanderstichele
    A, Ruscito I, Trillsch F, Mustea A, Kreuzinger C, Gourley C, Gabra H, Taube ET,
    Dorigo O, Horst D, Keunecke C, Baum J, Angelotti T, Sehouli J, Braicu EI. 2023.
    Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome
    and patient survival in primary and recurrent high-grade serous ovarian cancer:
    A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models
    Prolong Survival (OCTIPS) consortium. Annals of Surgical Oncology. 30, 35–45.'
  mla: 'Glajzer, Jacek, et al. “Impact of BRCA Mutation Status on Tumor Dissemination
    Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade
    Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer
    Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium.” <i>Annals of
    Surgical Oncology</i>, vol. 30, Springer Nature, 2023, pp. 35–45, doi:<a href="https://doi.org/10.1245/s10434-022-12459-3">10.1245/s10434-022-12459-3</a>.'
  short: J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele,
    I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T.
    Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I.
    Braicu, Annals of Surgical Oncology 30 (2023) 35–45.
date_created: 2023-01-16T09:44:36Z
date_published: 2023-01-01T00:00:00Z
date_updated: 2023-09-05T15:18:37Z
day: '01'
ddc:
- '610'
department:
- _id: JoDa
doi: 10.1245/s10434-022-12459-3
external_id:
  isi:
  - '000852125500006'
file:
- access_level: open_access
  checksum: 36a1200e1011f4b2155a8041d0308f34
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  date_created: 2023-02-02T13:01:20Z
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  relation: main_file
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file_date_updated: 2023-02-02T13:01:20Z
has_accepted_license: '1'
intvolume: '        30'
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keyword:
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- Surgery
language:
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license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
page: 35-45
publication: Annals of Surgical Oncology
publication_identifier:
  eissn:
  - 1534-4681
  issn:
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publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '12115'
    relation: other
    status: public
scopus_import: '1'
status: public
title: 'Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome
  and patient survival in primary and recurrent high-grade serous ovarian cancer:
  A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models
  Prolong Survival (OCTIPS) consortium'
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type: journal_article
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volume: 30
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...