[{"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/chem.202202967"}],"type":"journal_article","date_published":"2023-01-18T00:00:00Z","oa":1,"publication_identifier":{"issn":["0947-6539"],"eissn":["1521-3765"]},"keyword":["General Chemistry","Catalysis","Organic Chemistry"],"language":[{"iso":"eng"}],"publication":"Chemistry – A European Journal","article_number":"e202202967","month":"01","oa_version":"Published Version","extern":"1","volume":29,"citation":{"chicago":"Traxler, Michael, Susanne Reischauer, Sarah Vogl, Jérôme Roeser, Jabor Rabeah, Christopher Penschke, Peter Saalfrank, Bartholomäus Pieber, and Arne Thomas. “Programmable Photocatalytic Activity of Multicomponent Covalent Organic Frameworks Used as Metallaphotocatalysts.” <i>Chemistry – A European Journal</i>. Wiley, 2023. <a href=\"https://doi.org/10.1002/chem.202202967\">https://doi.org/10.1002/chem.202202967</a>.","ieee":"M. Traxler <i>et al.</i>, “Programmable photocatalytic activity of multicomponent covalent organic frameworks used as metallaphotocatalysts,” <i>Chemistry – A European Journal</i>, vol. 29, no. 4. Wiley, 2023.","ama":"Traxler M, Reischauer S, Vogl S, et al. Programmable photocatalytic activity of multicomponent covalent organic frameworks used as metallaphotocatalysts. <i>Chemistry – A European Journal</i>. 2023;29(4). doi:<a href=\"https://doi.org/10.1002/chem.202202967\">10.1002/chem.202202967</a>","apa":"Traxler, M., Reischauer, S., Vogl, S., Roeser, J., Rabeah, J., Penschke, C., … Thomas, A. (2023). Programmable photocatalytic activity of multicomponent covalent organic frameworks used as metallaphotocatalysts. <i>Chemistry – A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.202202967\">https://doi.org/10.1002/chem.202202967</a>","ista":"Traxler M, Reischauer S, Vogl S, Roeser J, Rabeah J, Penschke C, Saalfrank P, Pieber B, Thomas A. 2023. Programmable photocatalytic activity of multicomponent covalent organic frameworks used as metallaphotocatalysts. Chemistry – A European Journal. 29(4), e202202967.","short":"M. Traxler, S. Reischauer, S. Vogl, J. Roeser, J. Rabeah, C. Penschke, P. Saalfrank, B. Pieber, A. Thomas, Chemistry – A European Journal 29 (2023).","mla":"Traxler, Michael, et al. “Programmable Photocatalytic Activity of Multicomponent Covalent Organic Frameworks Used as Metallaphotocatalysts.” <i>Chemistry – A European Journal</i>, vol. 29, no. 4, e202202967, Wiley, 2023, doi:<a href=\"https://doi.org/10.1002/chem.202202967\">10.1002/chem.202202967</a>."},"year":"2023","date_updated":"2023-05-15T08:39:24Z","abstract":[{"text":"The multicomponent approach allows to incorporate several functionalities into a single covalent organic framework (COF) and consequently allows the construction of bifunctional materials for cooperative catalysis. The well-defined structure of such multicomponent COFs is furthermore ideally suited for structure-activity relationship studies. We report a series of multicomponent COFs that contain acridine- and 2,2’-bipyridine linkers connected through 1,3,5-benzenetrialdehyde derivatives. The acridine motif is responsible for broad light absorption, while the bipyridine unit enables complexation of nickel catalysts. These features enable the usage of the framework materials as catalysts for light-mediated carbon−heteroatom cross-couplings. Variation of the node units shows that the catalytic activity correlates to the keto-enamine tautomer isomerism. This allows switching between high charge-carrier mobility and persistent, localized charge-separated species depending on the nodes, a tool to tailor the materials for specific reactions. Moreover, nickel-loaded COFs are recyclable and catalyze cross-couplings even using red light irradiation.","lang":"eng"}],"day":"18","doi":"10.1002/chem.202202967","quality_controlled":"1","article_type":"original","publisher":"Wiley","issue":"4","author":[{"first_name":"Michael","last_name":"Traxler","full_name":"Traxler, Michael"},{"full_name":"Reischauer, Susanne","first_name":"Susanne","last_name":"Reischauer"},{"last_name":"Vogl","first_name":"Sarah","full_name":"Vogl, Sarah"},{"last_name":"Roeser","first_name":"Jérôme","full_name":"Roeser, Jérôme"},{"first_name":"Jabor","last_name":"Rabeah","full_name":"Rabeah, Jabor"},{"full_name":"Penschke, Christopher","last_name":"Penschke","first_name":"Christopher"},{"full_name":"Saalfrank, Peter","last_name":"Saalfrank","first_name":"Peter"},{"full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X","last_name":"Pieber","first_name":"Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"},{"full_name":"Thomas, Arne","last_name":"Thomas","first_name":"Arne"}],"scopus_import":"1","_id":"12920","intvolume":"        29","title":"Programmable photocatalytic activity of multicomponent covalent organic frameworks used as metallaphotocatalysts","date_created":"2023-05-08T08:25:34Z","article_processing_charge":"No","publication_status":"published"},{"publication":"Chemistry - A European Journal","oa_version":"None","month":"03","language":[{"iso":"eng"}],"date_published":"2015-03-09T00:00:00Z","type":"journal_article","publication_identifier":{"eissn":["1521-3765"],"issn":["0947-6539"]},"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"_id":"11962","scopus_import":"1","author":[{"first_name":"Bartholomäus","last_name":"Pieber","orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"},{"first_name":"Toma","last_name":"Glasnov","full_name":"Glasnov, Toma"},{"full_name":"Kappe, C. Oliver","first_name":"C. Oliver","last_name":"Kappe"}],"issue":"11","publication_status":"published","date_created":"2022-08-24T11:11:10Z","article_processing_charge":"No","title":"Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs","intvolume":"        21","page":"4368-4376","quality_controlled":"1","publisher":"Wiley","article_type":"original","date_updated":"2023-02-21T10:09:30Z","year":"2015","citation":{"apa":"Pieber, B., Glasnov, T., &#38; Kappe, C. O. (2015). Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs. <i>Chemistry - A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.201406439\">https://doi.org/10.1002/chem.201406439</a>","ama":"Pieber B, Glasnov T, Kappe CO. Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs. <i>Chemistry - A European Journal</i>. 2015;21(11):4368-4376. doi:<a href=\"https://doi.org/10.1002/chem.201406439\">10.1002/chem.201406439</a>","chicago":"Pieber, Bartholomäus, Toma Glasnov, and C. Oliver Kappe. “Continuous Flow Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies-Closing the Gap towards a Fully Continuous Synthesis of Antimalarial Drugs.” <i>Chemistry - A European Journal</i>. Wiley, 2015. <a href=\"https://doi.org/10.1002/chem.201406439\">https://doi.org/10.1002/chem.201406439</a>.","ieee":"B. Pieber, T. Glasnov, and C. O. Kappe, “Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs,” <i>Chemistry - A European Journal</i>, vol. 21, no. 11. Wiley, pp. 4368–4376, 2015.","short":"B. Pieber, T. Glasnov, C.O. Kappe, Chemistry - A European Journal 21 (2015) 4368–4376.","mla":"Pieber, Bartholomäus, et al. “Continuous Flow Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies-Closing the Gap towards a Fully Continuous Synthesis of Antimalarial Drugs.” <i>Chemistry - A European Journal</i>, vol. 21, no. 11, Wiley, 2015, pp. 4368–76, doi:<a href=\"https://doi.org/10.1002/chem.201406439\">10.1002/chem.201406439</a>.","ista":"Pieber B, Glasnov T, Kappe CO. 2015. Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs. Chemistry - A European Journal. 21(11), 4368–4376."},"external_id":{"pmid":["25655090"]},"doi":"10.1002/chem.201406439","day":"09","abstract":[{"text":"One of the rare alternative reagents for the reduction of carbon–carbon double bonds is diimide (HNNH), which can be generated in situ from hydrazine hydrate (N2H4⋅H2O) and O2. Although this selective method is extremely clean and powerful, it is rarely used, as the rate-determining oxidation of hydrazine in the absence of a catalyst is relatively slow using conventional batch protocols. A continuous high-temperature/high-pressure methodology dramatically enhances the initial oxidation step, at the same time allowing for a safe and scalable processing of the hazardous reaction mixture. Simple alkenes can be selectively reduced within 10–20 min at 100–120 °C and 20 bar O2 pressure. The development of a multi-injection reactor platform for the periodic addition of N2H4⋅H2O enables the reduction of less reactive olefins even at lower reaction temperatures. This concept was utilized for the highly selective reduction of artemisinic acid to dihydroartemisinic acid, the precursor molecule for the semisynthesis of the antimalarial drug artemisinin. The industrially relevant reduction was achieved by using four consecutive liquid feeds (of N2H4⋅H2O) and residence time units resulting in a highly selective reduction within approximately 40 min at 60 °C and 20 bar O2 pressure, providing dihydroartemisinic acid in ≥93 % yield and ≥95 % selectivity.","lang":"eng"}],"volume":21,"extern":"1"},{"publication":"Chemistry - A European Journal","oa_version":"None","month":"05","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2012-05-14T00:00:00Z","publication_identifier":{"issn":["0947-6539"],"eissn":["1521-3765"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","scopus_import":"1","pmid":1,"_id":"11963","issue":"20","author":[{"full_name":"Kumar, G. Sathish","last_name":"Kumar","first_name":"G. Sathish"},{"orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","first_name":"Bartholomäus","last_name":"Pieber","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"},{"last_name":"Reddy","first_name":"K. Rajender","full_name":"Reddy, K. Rajender"},{"full_name":"Kappe, C. Oliver","last_name":"Kappe","first_name":"C. Oliver"}],"date_created":"2022-08-24T12:33:05Z","article_processing_charge":"No","publication_status":"published","intvolume":"        18","title":"Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats","quality_controlled":"1","page":"6124-6128","publisher":"Wiley","article_type":"letter_note","citation":{"apa":"Kumar, G. S., Pieber, B., Reddy, K. R., &#38; Kappe, C. O. (2012). Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats. <i>Chemistry - A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.201200815\">https://doi.org/10.1002/chem.201200815</a>","ama":"Kumar GS, Pieber B, Reddy KR, Kappe CO. Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats. <i>Chemistry - A European Journal</i>. 2012;18(20):6124-6128. doi:<a href=\"https://doi.org/10.1002/chem.201200815\">10.1002/chem.201200815</a>","chicago":"Kumar, G. Sathish, Bartholomäus Pieber, K. Rajender Reddy, and C. Oliver Kappe. “Copper-Catalyzed Formation of C-O Bonds by Direct α-C-H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous-Flow Formats.” <i>Chemistry - A European Journal</i>. Wiley, 2012. <a href=\"https://doi.org/10.1002/chem.201200815\">https://doi.org/10.1002/chem.201200815</a>.","ieee":"G. S. Kumar, B. Pieber, K. R. Reddy, and C. O. Kappe, “Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats,” <i>Chemistry - A European Journal</i>, vol. 18, no. 20. Wiley, pp. 6124–6128, 2012.","short":"G.S. Kumar, B. Pieber, K.R. Reddy, C.O. Kappe, Chemistry - A European Journal 18 (2012) 6124–6128.","mla":"Kumar, G. Sathish, et al. “Copper-Catalyzed Formation of C-O Bonds by Direct α-C-H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous-Flow Formats.” <i>Chemistry - A European Journal</i>, vol. 18, no. 20, Wiley, 2012, pp. 6124–28, doi:<a href=\"https://doi.org/10.1002/chem.201200815\">10.1002/chem.201200815</a>.","ista":"Kumar GS, Pieber B, Reddy KR, Kappe CO. 2012. Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats. Chemistry - A European Journal. 18(20), 6124–6128."},"year":"2012","date_updated":"2023-02-21T10:09:33Z","external_id":{"pmid":["22492535"]},"day":"14","doi":"10.1002/chem.201200815","abstract":[{"lang":"eng","text":"Peroxides and ethers in flow: 2-Carbonyl-substituted phenols and β-ketoesters react safely with ethers in a microreactor environment using a copper catalyst and an organic peroxide (TBHP). This protocol results in unsymmetrical acetal scaffolds not easily available otherwise (see scheme)."}],"volume":18,"extern":"1"},{"intvolume":"        18","title":"Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry","article_processing_charge":"No","date_created":"2022-08-24T12:48:28Z","publication_status":"published","issue":"16","author":[{"first_name":"Bartholomäus","last_name":"Pieber","orcid":"0000-0001-8689-388X","full_name":"Pieber, Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726"},{"full_name":"Cantillo, David","first_name":"David","last_name":"Cantillo"},{"full_name":"Kappe, C. Oliver","first_name":"C. Oliver","last_name":"Kappe"}],"scopus_import":"1","_id":"11964","pmid":1,"article_type":"original","publisher":"Wiley","quality_controlled":"1","page":"5047-5055","abstract":[{"lang":"eng","text":"A detailed investigation on the direct arylation of benzene with aryl bromides by using first-row transition metals under high-temperature/high-pressure (high-T/p) conditions is described. By employing a parallel reactor platform for rapid reaction screening and discovery at elevated temperatures, various metal/ligand/base combinations were evaluated for their ability to enable biaryl formation through C-H activation. The combination of cobalt(III) acetylacetonate and lithium bis(trimethylsilyl)amide was subjected to further process intensification at 200 °C (15 bar), allowing a significant reduction of the catalyst/base loading and a dramatic increase in catalytic efficiency (turnover frequency) by a factor of 1000 compared to traditional protocols. The high-throughput screening additionally identified novel nickel- and copper-based metal/ligand combinations that favored an amination pathway competing with C-H activation, with the addition of ligands, such as 1,10-phenanthroline, having a profound influence on the selectivity. In addition to metal-based catalysts, high-T/p process windows were also successfully applied to transition-metal-free systems, utilizing 1,10-phenanthroline as organocatalyst."}],"day":"16","doi":"10.1002/chem.201103748","external_id":{"pmid":["22396386"]},"citation":{"chicago":"Pieber, Bartholomäus, David Cantillo, and C. Oliver Kappe. “Direct Arylation of Benzene with Aryl Bromides Using High‐temperature/High‐pressure Process Windows: Expanding the Scope of C-H Activation Chemistry.” <i>Chemistry – A European Journal</i>. Wiley, 2012. <a href=\"https://doi.org/10.1002/chem.201103748\">https://doi.org/10.1002/chem.201103748</a>.","ieee":"B. Pieber, D. Cantillo, and C. O. Kappe, “Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry,” <i>Chemistry – A European Journal</i>, vol. 18, no. 16. Wiley, pp. 5047–5055, 2012.","apa":"Pieber, B., Cantillo, D., &#38; Kappe, C. O. (2012). Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry. <i>Chemistry – A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.201103748\">https://doi.org/10.1002/chem.201103748</a>","ama":"Pieber B, Cantillo D, Kappe CO. Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry. <i>Chemistry – A European Journal</i>. 2012;18(16):5047-5055. doi:<a href=\"https://doi.org/10.1002/chem.201103748\">10.1002/chem.201103748</a>","ista":"Pieber B, Cantillo D, Kappe CO. 2012. Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry. Chemistry – A European Journal. 18(16), 5047–5055.","mla":"Pieber, Bartholomäus, et al. “Direct Arylation of Benzene with Aryl Bromides Using High‐temperature/High‐pressure Process Windows: Expanding the Scope of C-H Activation Chemistry.” <i>Chemistry – A European Journal</i>, vol. 18, no. 16, Wiley, 2012, pp. 5047–55, doi:<a href=\"https://doi.org/10.1002/chem.201103748\">10.1002/chem.201103748</a>.","short":"B. Pieber, D. Cantillo, C.O. Kappe, Chemistry – A European Journal 18 (2012) 5047–5055."},"year":"2012","date_updated":"2023-02-21T10:09:35Z","extern":"1","volume":18,"month":"04","oa_version":"None","publication":"Chemistry – A European Journal","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0947-6539"],"eissn":["1521-3765"]},"type":"journal_article","date_published":"2012-04-16T00:00:00Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"}]