---
_id: '14835'
abstract:
- lang: ger
  text: Aromatische Seitenketten sind wichtige Indikatoren für die Plastizität von
    Proteinen und bilden oft entscheidende Kontakte bei Protein‐Protein‐Wechselwirkungen.
    Wir untersuchten aromatische Reste in den beiden strukturell homologen cross‐β
    Amyloidfibrillen HET‐s und HELLF mit Hilfe eines spezifischen Ansatzes zur Isotopenmarkierung
    und Festkörper NMR mit Drehung am magischen Winkel. Das dynamische Verhalten der
    aromatischen Reste Phe und Tyr deutet darauf hin, dass der hydrophobe Amyloidkern
    starr ist und keine Anzeichen von “atmenden Bewegungen” auf einer Zeitskala von
    Hunderten von Millisekunden zeigt. Aromatische Reste, die exponiert an der Fibrillenoberfläche
    sitzen, haben zwar eine starre Ringachse, weisen aber Ringflips auf verschiedenen
    Zeitskalen von Nanosekunden bis Mikrosekunden auf. Unser Ansatz bietet einen direkten
    Einblick in die Bewegungen des hydrophoben Kerns und ermöglicht eine bessere Bewertung
    der Konformationsheterogenität, die aus einem NMR‐Strukturensemble einer solchen
    Cross‐β‐Amyloidstruktur hervorgeht.
acknowledgement: Wir danken Albert A. Smith (Leipzig) für aufschlussreiche Diskussionen.
  Diese Arbeit wurde mit Mitteln des Europäischen Forschungsrats (StG-2012-311318
  an P.S.) unterstützt und nutzte die Plattformen des Grenoble Instruct-ERIC Center
  (ISBG; UMS 3518 CNRS-CEA-UJF-EMBL) im Rahmen der Grenoble Partnership for Structural
  Biology (PSB) sowie die Einrichtungen und das Fachwissen der Biophysical and Structural
  Chemistry Platform (BPCS) am IECB, CNRS UAR3033, INSERM US001 und der Universität
  Bordeaux.
article_number: e202219314
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Lea Marie
  full_name: Becker, Lea Marie
  id: 36336939-eb97-11eb-a6c2-c83f1214ca79
  last_name: Becker
  orcid: 0000-0002-6401-5151
- first_name: Mélanie
  full_name: Berbon, Mélanie
  last_name: Berbon
- first_name: Alicia
  full_name: Vallet, Alicia
  last_name: Vallet
- first_name: Axelle
  full_name: Grelard, Axelle
  last_name: Grelard
- first_name: Estelle
  full_name: Morvan, Estelle
  last_name: Morvan
- first_name: Benjamin
  full_name: Bardiaux, Benjamin
  last_name: Bardiaux
- first_name: Roman
  full_name: Lichtenecker, Roman
  last_name: Lichtenecker
- first_name: Matthias
  full_name: Ernst, Matthias
  last_name: Ernst
- first_name: Antoine
  full_name: Loquet, Antoine
  last_name: Loquet
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: Becker LM, Berbon M, Vallet A, et al. Der starre Kern und die flexible Oberfläche
    von Amyloidfibrillen – Magic‐Angle‐Spinning NMR Spektroskopie von aromatischen
    Resten. <i>Angewandte Chemie</i>. 2023;135(19). doi:<a href="https://doi.org/10.1002/ange.202219314">10.1002/ange.202219314</a>
  apa: Becker, L. M., Berbon, M., Vallet, A., Grelard, A., Morvan, E., Bardiaux, B.,
    … Schanda, P. (2023). Der starre Kern und die flexible Oberfläche von Amyloidfibrillen
    – Magic‐Angle‐Spinning NMR Spektroskopie von aromatischen Resten. <i>Angewandte
    Chemie</i>. Wiley. <a href="https://doi.org/10.1002/ange.202219314">https://doi.org/10.1002/ange.202219314</a>
  chicago: Becker, Lea Marie, Mélanie Berbon, Alicia Vallet, Axelle Grelard, Estelle
    Morvan, Benjamin Bardiaux, Roman Lichtenecker, Matthias Ernst, Antoine Loquet,
    and Paul Schanda. “Der starre Kern und die flexible Oberfläche von Amyloidfibrillen
    – Magic‐Angle‐Spinning NMR Spektroskopie von aromatischen Resten.” <i>Angewandte
    Chemie</i>. Wiley, 2023. <a href="https://doi.org/10.1002/ange.202219314">https://doi.org/10.1002/ange.202219314</a>.
  ieee: L. M. Becker <i>et al.</i>, “Der starre Kern und die flexible Oberfläche von
    Amyloidfibrillen – Magic‐Angle‐Spinning NMR Spektroskopie von aromatischen Resten,”
    <i>Angewandte Chemie</i>, vol. 135, no. 19. Wiley, 2023.
  ista: Becker LM, Berbon M, Vallet A, Grelard A, Morvan E, Bardiaux B, Lichtenecker
    R, Ernst M, Loquet A, Schanda P. 2023. Der starre Kern und die flexible Oberfläche
    von Amyloidfibrillen – Magic‐Angle‐Spinning NMR Spektroskopie von aromatischen
    Resten. Angewandte Chemie. 135(19), e202219314.
  mla: Becker, Lea Marie, et al. “Der starre Kern und die flexible Oberfläche von
    Amyloidfibrillen – Magic‐Angle‐Spinning NMR Spektroskopie von aromatischen Resten.”
    <i>Angewandte Chemie</i>, vol. 135, no. 19, e202219314, Wiley, 2023, doi:<a href="https://doi.org/10.1002/ange.202219314">10.1002/ange.202219314</a>.
  short: L.M. Becker, M. Berbon, A. Vallet, A. Grelard, E. Morvan, B. Bardiaux, R.
    Lichtenecker, M. Ernst, A. Loquet, P. Schanda, Angewandte Chemie 135 (2023).
date_created: 2024-01-18T10:01:01Z
date_published: 2023-05-02T00:00:00Z
date_updated: 2024-01-23T12:23:35Z
day: '02'
ddc:
- '540'
department:
- _id: PaSc
doi: 10.1002/ange.202219314
file:
- access_level: open_access
  checksum: 98e68d370159f7be52a3d7c8a8ee1198
  content_type: application/pdf
  creator: dernst
  date_created: 2024-01-23T08:57:01Z
  date_updated: 2024-01-23T08:57:01Z
  file_id: '14876'
  file_name: 2023_AngewChem_Becker.pdf
  file_size: 1004676
  relation: main_file
  success: 1
file_date_updated: 2024-01-23T08:57:01Z
has_accepted_license: '1'
intvolume: '       135'
issue: '19'
keyword:
- General Medicine
language:
- iso: ger
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '05'
oa: 1
oa_version: Published Version
publication: Angewandte Chemie
publication_identifier:
  eissn:
  - 1521-3757
  issn:
  - 0044-8249
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Der starre Kern und die flexible Oberfläche von Amyloidfibrillen – Magic‐Angle‐Spinning
  NMR Spektroskopie von aromatischen Resten
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 135
year: '2023'
...
---
_id: '8057'
abstract:
- lang: eng
  text: Water-in-salt electrolytes based on highly concentrated bis(trifluoromethyl)sulfonimide
    (TFSI) promise aqueous electrolytes with stabilities approaching 3 V. However,
    especially with an electrode approaching the cathodic (reductive) stability, cycling
    stability is insufficient. While stability critically relies on a solid electrolyte
    interphase (SEI), the mechanism behind the cathodic stability limit remains unclear.
    Here, we reveal two distinct reduction potentials for the chemical environments
    of ‘free’ and ‘bound’ water and that both contribute to SEI formation. Free-water
    is reduced ~1V above bound water in a hydrogen evolution reaction (HER) and responsible
    for SEI formation via reactive intermediates of the HER; concurrent LiTFSI precipitation/dissolution
    establishes a dynamic interface. The free-water population emerges, therefore,
    as the handle to extend the cathodic limit of aqueous electrolytes and the battery
    cycling stability.
article_processing_charge: No
article_type: original
author:
- first_name: Roza
  full_name: Bouchal, Roza
  last_name: Bouchal
- first_name: Zhujie
  full_name: Li, Zhujie
  last_name: Li
- first_name: Chandra
  full_name: Bongu, Chandra
  last_name: Bongu
- first_name: Steven
  full_name: Le Vot, Steven
  last_name: Le Vot
- first_name: Romain
  full_name: Berthelot, Romain
  last_name: Berthelot
- first_name: Benjamin
  full_name: Rotenberg, Benjamin
  last_name: Rotenberg
- first_name: Frederic
  full_name: Favier, Frederic
  last_name: Favier
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Mathieu
  full_name: Salanne, Mathieu
  last_name: Salanne
- first_name: Olivier
  full_name: Fontaine, Olivier
  last_name: Fontaine
citation:
  ama: Bouchal R, Li Z, Bongu C, et al. Competitive salt precipitation/dissolution
    during free‐water reduction in water‐in‐salt electrolyte. <i>Angewandte Chemie</i>.
    2020;132(37):16047-16051. doi:<a href="https://doi.org/10.1002/ange.202005378">10.1002/ange.202005378</a>
  apa: Bouchal, R., Li, Z., Bongu, C., Le Vot, S., Berthelot, R., Rotenberg, B., …
    Fontaine, O. (2020). Competitive salt precipitation/dissolution during free‐water
    reduction in water‐in‐salt electrolyte. <i>Angewandte Chemie</i>. Wiley. <a href="https://doi.org/10.1002/ange.202005378">https://doi.org/10.1002/ange.202005378</a>
  chicago: Bouchal, Roza, Zhujie Li, Chandra Bongu, Steven Le Vot, Romain Berthelot,
    Benjamin Rotenberg, Frederic Favier, Stefan Alexander Freunberger, Mathieu Salanne,
    and Olivier Fontaine. “Competitive Salt Precipitation/Dissolution during Free‐water
    Reduction in Water‐in‐salt Electrolyte.” <i>Angewandte Chemie</i>. Wiley, 2020.
    <a href="https://doi.org/10.1002/ange.202005378">https://doi.org/10.1002/ange.202005378</a>.
  ieee: R. Bouchal <i>et al.</i>, “Competitive salt precipitation/dissolution during
    free‐water reduction in water‐in‐salt electrolyte,” <i>Angewandte Chemie</i>,
    vol. 132, no. 37. Wiley, pp. 16047–16051, 2020.
  ista: Bouchal R, Li Z, Bongu C, Le Vot S, Berthelot R, Rotenberg B, Favier F, Freunberger
    SA, Salanne M, Fontaine O. 2020. Competitive salt precipitation/dissolution during
    free‐water reduction in water‐in‐salt electrolyte. Angewandte Chemie. 132(37),
    16047–16051.
  mla: Bouchal, Roza, et al. “Competitive Salt Precipitation/Dissolution during Free‐water
    Reduction in Water‐in‐salt Electrolyte.” <i>Angewandte Chemie</i>, vol. 132, no.
    37, Wiley, 2020, pp. 16047–51, doi:<a href="https://doi.org/10.1002/ange.202005378">10.1002/ange.202005378</a>.
  short: R. Bouchal, Z. Li, C. Bongu, S. Le Vot, R. Berthelot, B. Rotenberg, F. Favier,
    S.A. Freunberger, M. Salanne, O. Fontaine, Angewandte Chemie 132 (2020) 16047–16051.
date_created: 2020-06-29T16:15:49Z
date_published: 2020-09-07T00:00:00Z
date_updated: 2023-09-05T15:47:50Z
day: '07'
ddc:
- '540'
- '541'
department:
- _id: StFr
doi: 10.1002/ange.202005378
file:
- access_level: open_access
  checksum: 7dd0a56f6bd5de08ea75b1ec388c91bc
  content_type: application/pdf
  creator: dernst
  date_created: 2020-09-17T08:59:43Z
  date_updated: 2020-09-17T08:59:43Z
  file_id: '8401'
  file_name: 2020_AngChemieDE_Bouchal.pdf
  file_size: 1904552
  relation: main_file
  success: 1
file_date_updated: 2020-09-17T08:59:43Z
has_accepted_license: '1'
intvolume: '       132'
issue: '37'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
page: 16047-16051
publication: Angewandte Chemie
publication_identifier:
  eissn:
  - 1521-3757
  issn:
  - 0044-8249
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Competitive salt precipitation/dissolution during free‐water reduction in water‐in‐salt
  electrolyte
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 132
year: '2020'
...