---
_id: '9349'
abstract:
- lang: eng
  text: 'The way in which interactions between mechanics and biochemistry lead to
    the emergence of complex cell and tissue organization is an old question that
    has recently attracted renewed interest from biologists, physicists, mathematicians
    and computer scientists. Rapid advances in optical physics, microscopy and computational
    image analysis have greatly enhanced our ability to observe and quantify spatiotemporal
    patterns of signalling, force generation, deformation, and flow in living cells
    and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation
    are allowing us to perturb the underlying machinery that generates these patterns
    in increasingly sophisticated ways. Rapid advances in theory and computing have
    made it possible to construct predictive models that describe how cell and tissue
    organization and dynamics emerge from the local coupling of biochemistry and mechanics.
    Together, these advances have opened up a wealth of new opportunities to explore
    how mechanochemical patterning shapes organismal development. In this roadmap,
    we present a series of forward-looking case studies on mechanochemical patterning
    in development, written by scientists working at the interface between the physical
    and biological sciences, and covering a wide range of spatial and temporal scales,
    organisms, and modes of development. Together, these contributions highlight the
    many ways in which the dynamic coupling of mechanics and biochemistry shapes biological
    dynamics: from mechanoenzymes that sense force to tune their activity and motor
    output, to collectives of cells in tissues that flow and redistribute biochemical
    signals during development.'
acknowledgement: The AK group is supported by IST Austria and by the ERC under European
  Union Horizon 2020 research and innovation programme Grant 680037. Apologies to
  those whose work could not be mentioned due to limited space. We thank all my lab
  members, both past and present, for stimulating discussion. This work was funded
  by a Singapore Ministry of Education Tier 3 Grant, MOE2016-T3-1-005. We thank Francis
  Corson for continuous discussion and collaboration contributing to these views and
  for figure 4(A). PC is sponsored by the Institut Pasteur and the European Union's
  Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
  Grant Agreement No. 665807. Research in JG's laboratory is funded by the European
  Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC
  Grant Agreement No. 337635, Institut Pasteur, CNRS, Cercle FSER, Fondation pour
  la Recherche Medicale, the Vallee Foundation and the ANR-19-CE-13-0024 Grant. We
  thank Erez Braun and Alex Mogilner for comments on the manuscript and Niv Ierushalmi
  for help with figure 5. This project has received funding from the European Union's
  Horizon 2020 research and innovation programme under Grant Agreement No. ERC-2018-COG
  Grant 819174-HydraMechanics awarded to KK. EH thanks all lab members, as well as
  Pierre Recho, Tsuyoshi Hirashima, Diana Pinheiro and Carl-Philip Heisenberg, for
  fruitful discussions on these topics—and apologize for not being able to cite many
  very relevant publications due to the strict 10-reference limit. EH acknowledges
  the support of Austrian Science Fund (FWF) (P 31639) and the European Research Council
  under the European Union's Horizon 2020 Research and Innovation Programme Grant
  Agreements (851288). The authors acknowledge the inspiring scientists whose work
  could not be cited in this perspective due to space constraints; the members of
  the Gartner Lab for helpful discussions; the Barbara and Gerson Bakar Foundation,
  the Chan Zuckerberg Biohub Investigators Programme, the National Institute of Health,
  and the Centre for Cellular Construction, an NSF Science and Technology Centre.
  The Minc laboratory is currently funded by the CNRS and the European Research Council
  (CoG Forcaster No. 647073). Research in the lab of J-LM is supported by the Institut
  Curie, the Centre National de la Recherche Scientifique (CNRS), the Institut National
  de la Santé Et de la Recherche Médicale (INSERM), and is funded by grants from the
  ATIP-Avenir programme, the Fondation Schlumberger pour l'Éducation et la Recherche
  via the Fondation pour la Recherche Médicale, the European Research Council Starting
  Grant ERC-2017-StG 757557, the European Molecular Biology Organization Young Investigator
  programme (EMBO YIP), the INSERM transversal programme Human Development Cell Atlas
  (HuDeCA), Paris Sciences Lettres (PSL) 'nouvelle équipe' and QLife (17-CONV-0005)
  grants and Labex DEEP (ANR-11-LABX-0044) which are part of the IDEX PSL (ANR-10-IDEX-0001-02).
  We acknowledge useful discussions with Massimo Vergassola, Sebastian Streichan and
  my lab members. Work in my laboratory on Drosophila embryogenesis is partly supported
  by NIH-R01GM122936. The authors acknowledge the support by a grant from the European
  Research Council (Grant No. 682161). Lenne group is funded by a grant from the 'Investissements
  d'Avenir' French Government programme managed by the French National Research Agency
  (ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University—A*MIDEX,
  and ANR projects MechaResp (ANR-17-CE13-0032) and AdGastrulo (ANR-19-CE13-0022).
article_number: '041501'
article_processing_charge: No
article_type: original
author:
- first_name: Pierre François
  full_name: Lenne, Pierre François
  last_name: Lenne
- first_name: Edwin
  full_name: Munro, Edwin
  last_name: Munro
- first_name: Idse
  full_name: Heemskerk, Idse
  last_name: Heemskerk
- first_name: Aryeh
  full_name: Warmflash, Aryeh
  last_name: Warmflash
- first_name: Laura
  full_name: Bocanegra, Laura
  id: 4896F754-F248-11E8-B48F-1D18A9856A87
  last_name: Bocanegra
- first_name: Kasumi
  full_name: Kishi, Kasumi
  id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
  last_name: Kishi
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Yuchen
  full_name: Long, Yuchen
  last_name: Long
- first_name: Antoine
  full_name: Fruleux, Antoine
  last_name: Fruleux
- first_name: Arezki
  full_name: Boudaoud, Arezki
  last_name: Boudaoud
- first_name: Timothy E.
  full_name: Saunders, Timothy E.
  last_name: Saunders
- first_name: Paolo
  full_name: Caldarelli, Paolo
  last_name: Caldarelli
- first_name: Arthur
  full_name: Michaut, Arthur
  last_name: Michaut
- first_name: Jerome
  full_name: Gros, Jerome
  last_name: Gros
- first_name: Yonit
  full_name: Maroudas-Sacks, Yonit
  last_name: Maroudas-Sacks
- first_name: Kinneret
  full_name: Keren, Kinneret
  last_name: Keren
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Zev J.
  full_name: Gartner, Zev J.
  last_name: Gartner
- first_name: Benjamin
  full_name: Stormo, Benjamin
  last_name: Stormo
- first_name: Amy
  full_name: Gladfelter, Amy
  last_name: Gladfelter
- first_name: Alan
  full_name: Rodrigues, Alan
  last_name: Rodrigues
- first_name: Amy
  full_name: Shyer, Amy
  last_name: Shyer
- first_name: Nicolas
  full_name: Minc, Nicolas
  last_name: Minc
- first_name: Jean Léon
  full_name: Maître, Jean Léon
  last_name: Maître
- first_name: Stefano
  full_name: Di Talia, Stefano
  last_name: Di Talia
- first_name: Bassma
  full_name: Khamaisi, Bassma
  last_name: Khamaisi
- first_name: David
  full_name: Sprinzak, David
  last_name: Sprinzak
- first_name: Sham
  full_name: Tlili, Sham
  last_name: Tlili
citation:
  ama: Lenne PF, Munro E, Heemskerk I, et al. Roadmap for the multiscale coupling
    of biochemical and mechanical signals during development. <i>Physical biology</i>.
    2021;18(4). doi:<a href="https://doi.org/10.1088/1478-3975/abd0db">10.1088/1478-3975/abd0db</a>
  apa: Lenne, P. F., Munro, E., Heemskerk, I., Warmflash, A., Bocanegra, L., Kishi,
    K., … Tlili, S. (2021). Roadmap for the multiscale coupling of biochemical and
    mechanical signals during development. <i>Physical Biology</i>. IOP Publishing.
    <a href="https://doi.org/10.1088/1478-3975/abd0db">https://doi.org/10.1088/1478-3975/abd0db</a>
  chicago: Lenne, Pierre François, Edwin Munro, Idse Heemskerk, Aryeh Warmflash, Laura
    Bocanegra, Kasumi Kishi, Anna Kicheva, et al. “Roadmap for the Multiscale Coupling
    of Biochemical and Mechanical Signals during Development.” <i>Physical Biology</i>.
    IOP Publishing, 2021. <a href="https://doi.org/10.1088/1478-3975/abd0db">https://doi.org/10.1088/1478-3975/abd0db</a>.
  ieee: P. F. Lenne <i>et al.</i>, “Roadmap for the multiscale coupling of biochemical
    and mechanical signals during development,” <i>Physical biology</i>, vol. 18,
    no. 4. IOP Publishing, 2021.
  ista: Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva
    A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J,
    Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues
    A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021.
    Roadmap for the multiscale coupling of biochemical and mechanical signals during
    development. Physical biology. 18(4), 041501.
  mla: Lenne, Pierre François, et al. “Roadmap for the Multiscale Coupling of Biochemical
    and Mechanical Signals during Development.” <i>Physical Biology</i>, vol. 18,
    no. 4, 041501, IOP Publishing, 2021, doi:<a href="https://doi.org/10.1088/1478-3975/abd0db">10.1088/1478-3975/abd0db</a>.
  short: P.F. Lenne, E. Munro, I. Heemskerk, A. Warmflash, L. Bocanegra, K. Kishi,
    A. Kicheva, Y. Long, A. Fruleux, A. Boudaoud, T.E. Saunders, P. Caldarelli, A.
    Michaut, J. Gros, Y. Maroudas-Sacks, K. Keren, E.B. Hannezo, Z.J. Gartner, B.
    Stormo, A. Gladfelter, A. Rodrigues, A. Shyer, N. Minc, J.L. Maître, S. Di Talia,
    B. Khamaisi, D. Sprinzak, S. Tlili, Physical Biology 18 (2021).
date_created: 2021-04-25T22:01:29Z
date_published: 2021-04-14T00:00:00Z
date_updated: 2023-08-08T13:15:46Z
day: '14'
ddc:
- '570'
department:
- _id: AnKi
- _id: EdHa
doi: 10.1088/1478-3975/abd0db
ec_funded: 1
external_id:
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month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
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  grant_number: P31639
  name: Active mechano-chemical description of the cell cytoskeleton
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  name: Design Principles of Branching Morphogenesis
publication: Physical biology
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publisher: IOP Publishing
quality_controlled: '1'
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title: Roadmap for the multiscale coupling of biochemical and mechanical signals during
  development
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  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
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type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 18
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...