---
_id: '6898'
abstract:
- lang: eng
  text: "Background\r\n\r\nChlamydia are ancient intracellular pathogens with reduced,
    though strikingly conserved genome. Despite their parasitic lifestyle and isolated
    intracellular environment, these bacteria managed to avoid accumulation of deleterious
    mutations leading to subsequent genome degradation characteristic for many parasitic
    bacteria.\r\nResults\r\n\r\nWe report pan-genomic analysis of sixteen species
    from genus Chlamydia including identification and functional annotation of orthologous
    genes, and characterization of gene gains, losses, and rearrangements. We demonstrate
    the overall genome stability of these bacteria as indicated by a large fraction
    of common genes with conserved genomic locations. On the other hand, extreme evolvability
    is confined to several paralogous gene families such as polymorphic membrane proteins
    and phospholipase D, and likely is caused by the pressure from the host immune
    system.\r\nConclusions\r\n\r\nThis combination of a large, conserved core genome
    and a small, evolvable periphery likely reflect the balance between the selective
    pressure towards genome reduction and the need to adapt to escape from the host
    immunity."
article_number: '710'
article_processing_charge: No
author:
- first_name: Olga M.
  full_name: Sigalova, Olga M.
  last_name: Sigalova
- first_name: Andrei V.
  full_name: Chaplin, Andrei V.
  last_name: Chaplin
- first_name: Olga
  full_name: Bochkareva, Olga
  id: C4558D3C-6102-11E9-A62E-F418E6697425
  last_name: Bochkareva
  orcid: 0000-0003-1006-6639
- first_name: Pavel V.
  full_name: Shelyakin, Pavel V.
  last_name: Shelyakin
- first_name: Vsevolod A.
  full_name: Filaretov, Vsevolod A.
  last_name: Filaretov
- first_name: Evgeny E.
  full_name: Akkuratov, Evgeny E.
  last_name: Akkuratov
- first_name: Valentina
  full_name: Burskaia, Valentina
  last_name: Burskaia
- first_name: Mikhail S.
  full_name: Gelfand, Mikhail S.
  last_name: Gelfand
citation:
  ama: Sigalova OM, Chaplin AV, Bochkareva O, et al. Chlamydia pan-genomic analysis
    reveals balance between host adaptation and selective pressure to genome reduction.
    <i>BMC Genomics</i>. 2019;20(1). doi:<a href="https://doi.org/10.1186/s12864-019-6059-5">10.1186/s12864-019-6059-5</a>
  apa: Sigalova, O. M., Chaplin, A. V., Bochkareva, O., Shelyakin, P. V., Filaretov,
    V. A., Akkuratov, E. E., … Gelfand, M. S. (2019). Chlamydia pan-genomic analysis
    reveals balance between host adaptation and selective pressure to genome reduction.
    <i>BMC Genomics</i>. BioMed Central. <a href="https://doi.org/10.1186/s12864-019-6059-5">https://doi.org/10.1186/s12864-019-6059-5</a>
  chicago: Sigalova, Olga M., Andrei V. Chaplin, Olga Bochkareva, Pavel V. Shelyakin,
    Vsevolod A. Filaretov, Evgeny E. Akkuratov, Valentina Burskaia, and Mikhail S.
    Gelfand. “Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation
    and Selective Pressure to Genome Reduction.” <i>BMC Genomics</i>. BioMed Central,
    2019. <a href="https://doi.org/10.1186/s12864-019-6059-5">https://doi.org/10.1186/s12864-019-6059-5</a>.
  ieee: O. M. Sigalova <i>et al.</i>, “Chlamydia pan-genomic analysis reveals balance
    between host adaptation and selective pressure to genome reduction,” <i>BMC Genomics</i>,
    vol. 20, no. 1. BioMed Central, 2019.
  ista: Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov
    EE, Burskaia V, Gelfand MS. 2019. Chlamydia pan-genomic analysis reveals balance
    between host adaptation and selective pressure to genome reduction. BMC Genomics.
    20(1), 710.
  mla: Sigalova, Olga M., et al. “Chlamydia Pan-Genomic Analysis Reveals Balance between
    Host Adaptation and Selective Pressure to Genome Reduction.” <i>BMC Genomics</i>,
    vol. 20, no. 1, 710, BioMed Central, 2019, doi:<a href="https://doi.org/10.1186/s12864-019-6059-5">10.1186/s12864-019-6059-5</a>.
  short: O.M. Sigalova, A.V. Chaplin, O. Bochkareva, P.V. Shelyakin, V.A. Filaretov,
    E.E. Akkuratov, V. Burskaia, M.S. Gelfand, BMC Genomics 20 (2019).
date_created: 2019-09-22T22:00:36Z
date_published: 2019-09-12T00:00:00Z
date_updated: 2023-08-30T06:20:22Z
day: '12'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1186/s12864-019-6059-5
external_id:
  isi:
  - '000485256100001'
file:
- access_level: open_access
  checksum: b798773c5823012d31c812c9f7975da2
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-01T10:33:17Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6924'
  file_name: 2019_BioMed_Sigalova.pdf
  file_size: 4157175
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '        20'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
publication: BMC Genomics
publication_identifier:
  eissn:
  - '14712164'
publication_status: published
publisher: BioMed Central
quality_controlled: '1'
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scopus_import: '1'
status: public
title: Chlamydia pan-genomic analysis reveals balance between host adaptation and
  selective pressure to genome reduction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2019'
...