---
_id: '11059'
abstract:
- lang: eng
  text: The genome is packaged and organized nonrandomly within the 3D space of the
    nucleus to promote efficient gene expression and to faithfully maintain silencing
    of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope
    membrane, which contains a set of proteins that actively participate in chromatin
    organization and gene regulation. Technological advances are providing views of
    genome organization at unprecedented resolution and are beginning to reveal the
    ways that cells co-opt the structures of the nuclear periphery for nuclear organization
    and gene regulation. These genome regulatory roles of proteins of the nuclear
    periphery have important influences on development, disease and ageing.
article_processing_charge: No
article_type: review
author:
- first_name: Abigail
  full_name: Buchwalter, Abigail
  last_name: Buchwalter
- first_name: Jeanae M.
  full_name: Kaneshiro, Jeanae M.
  last_name: Kaneshiro
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: 'Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear
    periphery in genome regulation. <i>Nature Reviews Genetics</i>. 2019;20(1):39-50.
    doi:<a href="https://doi.org/10.1038/s41576-018-0063-5">10.1038/s41576-018-0063-5</a>'
  apa: 'Buchwalter, A., Kaneshiro, J. M., &#38; Hetzer, M. (2019). Coaching from the
    sidelines: The nuclear periphery in genome regulation. <i>Nature Reviews Genetics</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41576-018-0063-5">https://doi.org/10.1038/s41576-018-0063-5</a>'
  chicago: 'Buchwalter, Abigail, Jeanae M. Kaneshiro, and Martin Hetzer. “Coaching
    from the Sidelines: The Nuclear Periphery in Genome Regulation.” <i>Nature Reviews
    Genetics</i>. Springer Nature, 2019. <a href="https://doi.org/10.1038/s41576-018-0063-5">https://doi.org/10.1038/s41576-018-0063-5</a>.'
  ieee: 'A. Buchwalter, J. M. Kaneshiro, and M. Hetzer, “Coaching from the sidelines:
    The nuclear periphery in genome regulation,” <i>Nature Reviews Genetics</i>, vol.
    20, no. 1. Springer Nature, pp. 39–50, 2019.'
  ista: 'Buchwalter A, Kaneshiro JM, Hetzer M. 2019. Coaching from the sidelines:
    The nuclear periphery in genome regulation. Nature Reviews Genetics. 20(1), 39–50.'
  mla: 'Buchwalter, Abigail, et al. “Coaching from the Sidelines: The Nuclear Periphery
    in Genome Regulation.” <i>Nature Reviews Genetics</i>, vol. 20, no. 1, Springer
    Nature, 2019, pp. 39–50, doi:<a href="https://doi.org/10.1038/s41576-018-0063-5">10.1038/s41576-018-0063-5</a>.'
  short: A. Buchwalter, J.M. Kaneshiro, M. Hetzer, Nature Reviews Genetics 20 (2019)
    39–50.
date_created: 2022-04-07T07:44:45Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2022-07-18T08:31:42Z
day: '01'
doi: 10.1038/s41576-018-0063-5
extern: '1'
external_id:
  pmid:
  - '30356165'
intvolume: '        20'
issue: '1'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 39-50
pmid: 1
publication: Nature Reviews Genetics
publication_identifier:
  eissn:
  - 1471-0064
  issn:
  - 1471-0056
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Coaching from the sidelines: The nuclear periphery in genome regulation'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 20
year: '2019'
...