---
_id: '12919'
abstract:
- lang: eng
  text: We report the visible light photocatalytic cleavage of trityl thioethers or
    ethers under pH-neutral conditions. The method results in the formation of the
    respective symmetrical disulfides and alcohols in moderate to excellent yield.
    The protocol only requires the addition of a suitable photocatalyst and light
    rendering it orthogonal to several functionalities, including acid labile protective
    groups. The same conditions can be used to directly convert trityl-protected thiols
    into unsymmetrical disulfides or selenosulfides, and to cleave trityl resins in
    solid phase organic synthesis.
article_processing_charge: No
article_type: original
author:
- first_name: Sho
  full_name: Murakami, Sho
  last_name: Murakami
- first_name: Cosima
  full_name: Brudy, Cosima
  last_name: Brudy
- first_name: Moritz
  full_name: Bachmann, Moritz
  last_name: Bachmann
- first_name: Yoshiji
  full_name: Takemoto, Yoshiji
  last_name: Takemoto
- first_name: Bartholomäus
  full_name: Pieber, Bartholomäus
  id: 93e5e5b2-0da6-11ed-8a41-af589a024726
  last_name: Pieber
  orcid: 0000-0001-8689-388X
citation:
  ama: Murakami S, Brudy C, Bachmann M, Takemoto Y, Pieber B. Photocatalytic cleavage
    of trityl protected thiols and alcohols. <i>Synthesis</i>. 2023;55(09):1367-1374.
    doi:<a href="https://doi.org/10.1055/a-1979-5933">10.1055/a-1979-5933</a>
  apa: Murakami, S., Brudy, C., Bachmann, M., Takemoto, Y., &#38; Pieber, B. (2023).
    Photocatalytic cleavage of trityl protected thiols and alcohols. <i>Synthesis</i>.
    Georg Thieme Verlag. <a href="https://doi.org/10.1055/a-1979-5933">https://doi.org/10.1055/a-1979-5933</a>
  chicago: Murakami, Sho, Cosima Brudy, Moritz Bachmann, Yoshiji Takemoto, and Bartholomäus
    Pieber. “Photocatalytic Cleavage of Trityl Protected Thiols and Alcohols.” <i>Synthesis</i>.
    Georg Thieme Verlag, 2023. <a href="https://doi.org/10.1055/a-1979-5933">https://doi.org/10.1055/a-1979-5933</a>.
  ieee: S. Murakami, C. Brudy, M. Bachmann, Y. Takemoto, and B. Pieber, “Photocatalytic
    cleavage of trityl protected thiols and alcohols,” <i>Synthesis</i>, vol. 55,
    no. 09. Georg Thieme Verlag, pp. 1367–1374, 2023.
  ista: Murakami S, Brudy C, Bachmann M, Takemoto Y, Pieber B. 2023. Photocatalytic
    cleavage of trityl protected thiols and alcohols. Synthesis. 55(09), 1367–1374.
  mla: Murakami, Sho, et al. “Photocatalytic Cleavage of Trityl Protected Thiols and
    Alcohols.” <i>Synthesis</i>, vol. 55, no. 09, Georg Thieme Verlag, 2023, pp. 1367–74,
    doi:<a href="https://doi.org/10.1055/a-1979-5933">10.1055/a-1979-5933</a>.
  short: S. Murakami, C. Brudy, M. Bachmann, Y. Takemoto, B. Pieber, Synthesis 55
    (2023) 1367–1374.
date_created: 2023-05-08T08:25:08Z
date_published: 2023-05-01T00:00:00Z
date_updated: 2023-05-15T08:43:50Z
day: '01'
doi: 10.1055/a-1979-5933
extern: '1'
intvolume: '        55'
issue: '09'
keyword:
- Organic Chemistry
- Catalysis
language:
- iso: eng
month: '05'
oa_version: None
page: 1367-1374
publication: Synthesis
publication_identifier:
  eissn:
  - 1437-210X
  issn:
  - 0039-7881
publication_status: published
publisher: Georg Thieme Verlag
quality_controlled: '1'
scopus_import: '1'
status: public
title: Photocatalytic cleavage of trityl protected thiols and alcohols
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2023'
...