---
_id: '11099'
abstract:
- lang: eng
  text: Nuclear pore complexes (NPCs) serve as transport channels across the nuclear
    membrane, a double lipid bilayer that physically separates the nucleoplasm and
    cytoplasm of eukaryotic cells. New evidence suggests that the multiprotein nuclear
    pores also play a role in chromatin organization and gene expression. Given the
    importance of NPC function, it is not surprising that a growing list of human
    diseases and developmental defects have been linked to its malfunction. In order
    to fully understand the functional repertoire of NPCs and their essential role
    for nuclear organization, it is critical to determine the sequence of events that
    lead to the formation of nuclear pores. This is particularly relevant since NPC
    number, and possibly composition, are tightly linked to metabolic activity. Most
    of our knowledge is derived from NPC formation that occurs in dividing cells at
    the end of mitosis when the nuclear envelope (NE) and NPCs reform from disassembled
    precursors. However, NPC assembly also takes place during interphase into an intact
    NE. Importantly, this process is not restricted to dividing cells but also occurs
    during cell differentiation. Here, we will review aspects unique to this process,
    namely the regulation of nuclear expansion and the mechanisms of fusion between
    the outer and inner nuclear membranes. We will then discuss conserved and diverging
    mechanisms between post-mitotic and interphase assembly of the proteinaceous structure
    in light of recently published data.
article_processing_charge: No
article_type: review
author:
- first_name: Christine M.
  full_name: Doucet, Christine M.
  last_name: Doucet
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Doucet CM, Hetzer M. Nuclear pore biogenesis into an intact nuclear envelope.
    <i>Chromosoma</i>. 2010;119:469-477. doi:<a href="https://doi.org/10.1007/s00412-010-0289-2">10.1007/s00412-010-0289-2</a>
  apa: Doucet, C. M., &#38; Hetzer, M. (2010). Nuclear pore biogenesis into an intact
    nuclear envelope. <i>Chromosoma</i>. Springer Nature. <a href="https://doi.org/10.1007/s00412-010-0289-2">https://doi.org/10.1007/s00412-010-0289-2</a>
  chicago: Doucet, Christine M., and Martin Hetzer. “Nuclear Pore Biogenesis into
    an Intact Nuclear Envelope.” <i>Chromosoma</i>. Springer Nature, 2010. <a href="https://doi.org/10.1007/s00412-010-0289-2">https://doi.org/10.1007/s00412-010-0289-2</a>.
  ieee: C. M. Doucet and M. Hetzer, “Nuclear pore biogenesis into an intact nuclear
    envelope,” <i>Chromosoma</i>, vol. 119. Springer Nature, pp. 469–477, 2010.
  ista: Doucet CM, Hetzer M. 2010. Nuclear pore biogenesis into an intact nuclear
    envelope. Chromosoma. 119, 469–477.
  mla: Doucet, Christine M., and Martin Hetzer. “Nuclear Pore Biogenesis into an Intact
    Nuclear Envelope.” <i>Chromosoma</i>, vol. 119, Springer Nature, 2010, pp. 469–77,
    doi:<a href="https://doi.org/10.1007/s00412-010-0289-2">10.1007/s00412-010-0289-2</a>.
  short: C.M. Doucet, M. Hetzer, Chromosoma 119 (2010) 469–477.
date_created: 2022-04-07T07:53:12Z
date_published: 2010-10-01T00:00:00Z
date_updated: 2022-07-18T08:54:20Z
day: '01'
doi: 10.1007/s00412-010-0289-2
extern: '1'
external_id:
  pmid:
  - '20721671'
intvolume: '       119'
keyword:
- Genetics (clinical)
- Genetics
language:
- iso: eng
month: '10'
oa_version: None
page: 469-477
pmid: 1
publication: Chromosoma
publication_identifier:
  eissn:
  - 1432-0886
  issn:
  - 0009-5915
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nuclear pore biogenesis into an intact nuclear envelope
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 119
year: '2010'
...