[{"citation":{"ista":"Berdan EL, Barton NH, Butlin R, Charlesworth B, Faria R, Fragata I, Gilbert KJ, Jay P, Kapun M, Lotterhos KE, Mérot C, Durmaz Mitchell E, Pascual M, Peichel CL, Rafajlović M, Westram AM, Schaeffer SW, Johannesson K, Flatt T. 2023. How chromosomal inversions reorient the evolutionary process. Journal of Evolutionary Biology., 14242.","mla":"Berdan, Emma L., et al. “How Chromosomal Inversions Reorient the Evolutionary Process.” <i>Journal of Evolutionary Biology</i>, 14242, Wiley, 2023, doi:<a href=\"https://doi.org/10.1111/jeb.14242\">10.1111/jeb.14242</a>.","apa":"Berdan, E. L., Barton, N. H., Butlin, R., Charlesworth, B., Faria, R., Fragata, I., … Flatt, T. (2023). How chromosomal inversions reorient the evolutionary process. <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.14242\">https://doi.org/10.1111/jeb.14242</a>","ama":"Berdan EL, Barton NH, Butlin R, et al. How chromosomal inversions reorient the evolutionary process. <i>Journal of Evolutionary Biology</i>. 2023. doi:<a href=\"https://doi.org/10.1111/jeb.14242\">10.1111/jeb.14242</a>","short":"E.L. Berdan, N.H. Barton, R. Butlin, B. Charlesworth, R. Faria, I. Fragata, K.J. Gilbert, P. Jay, M. Kapun, K.E. Lotterhos, C. Mérot, E. Durmaz Mitchell, M. Pascual, C.L. Peichel, M. Rafajlović, A.M. Westram, S.W. Schaeffer, K. Johannesson, T. Flatt, Journal of Evolutionary Biology (2023).","ieee":"E. L. Berdan <i>et al.</i>, “How chromosomal inversions reorient the evolutionary process,” <i>Journal of Evolutionary Biology</i>. Wiley, 2023.","chicago":"Berdan, Emma L., Nicholas H Barton, Roger Butlin, Brian Charlesworth, Rui Faria, Inês Fragata, Kimberly J. Gilbert, et al. “How Chromosomal Inversions Reorient the Evolutionary Process.” <i>Journal of Evolutionary Biology</i>. Wiley, 2023. <a href=\"https://doi.org/10.1111/jeb.14242\">https://doi.org/10.1111/jeb.14242</a>."},"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1111/jeb.14242"}],"date_published":"2023-11-08T00:00:00Z","ddc":["570"],"has_accepted_license":"1","oa":1,"publication_status":"epub_ahead","_id":"14556","year":"2023","acknowledgement":"We are grateful to two referees and Luke Holman for valuable comments on a previous version of our manuscript. This paper was conceived at the ESEB Progress Meeting ‘Disentangling neutral versus adaptive evolution in chromosomal inversions’, organized by ELB, KJ and TF and held at Tjärnö Marine Laboratory (Sweden) between 28 February and 3 March 2022. We are indebted to ESEB for sponsoring our workshop and to the following funding bodies for supporting our research: ERC AdG 101055327 to NHB; Swedish Research Council (VR) 2018-03695 and Leverhulme Trust RPG-2021-141 to RKB; Fundação para a Ciência e a Tecnologia (FCT) contract 2020.00275.CEECIND and research project PTDC/BIA-1232 EVL/1614/2021 to RF; Fundação para a Ciência e a Tecnologia (FCT) junior researcher contract CEECIND/02616/2018 to IF; Swiss National Science Foundation (SNSF) Ambizione #PZ00P3_185952 to KJG; National Science Foundation NSF-OCE 2043905 and NSF-DEB 1655701 to KEL; Swiss National Science Foundation (SNSF) 310030_204681 to CLP; Swedish Research Council (VR) 2021-05243 to MR; Norwegian Research Council grant 315287 to AMW; Swiss National Science Foundation (SNSF) 31003A-182262 and FZEB-0-214654 to TF. We also thank Luca Ferretti for the discussion and Eliane Zinn (Flatt lab) for help with reference formatting.","date_created":"2023-11-19T23:00:55Z","oa_version":"Published Version","month":"11","type":"journal_article","date_updated":"2023-11-20T08:51:09Z","abstract":[{"lang":"eng","text":"Inversions are structural mutations that reverse the sequence of a chromosome segment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation, as well as in other evolutionary processes such as speciation. Although inversions have been studied since the 1920s, they remain difficult to investigate because the reduced recombination conferred by them strengthens the effects of drift and hitchhiking, which in turn can obscure signatures of selection. Nonetheless, numerous inversions have been found to be under selection. Given recent advances in population genetic theory and empirical study, here we review how different mechanisms of selection affect the evolution of inversions. A key difference between inversions and other mutations, such as single nucleotide variants, is that the fitness of an inversion may be affected by a larger number of frequently interacting processes. This considerably complicates the analysis of the causes underlying the evolution of inversions. We discuss the extent to which these mechanisms can be disentangled, and by which approach."}],"language":[{"iso":"eng"}],"quality_controlled":"1","doi":"10.1111/jeb.14242","publication_identifier":{"issn":["1010-061X"],"eissn":["1420-9101"]},"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"article_type":"review","scopus_import":"1","article_processing_charge":"No","publication":"Journal of Evolutionary Biology","department":[{"_id":"NiBa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Wiley","article_number":"14242","title":"How chromosomal inversions reorient the evolutionary process","day":"08","author":[{"last_name":"Berdan","first_name":"Emma L.","full_name":"Berdan, Emma L."},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H"},{"full_name":"Butlin, Roger","first_name":"Roger","last_name":"Butlin"},{"full_name":"Charlesworth, Brian","first_name":"Brian","last_name":"Charlesworth"},{"last_name":"Faria","first_name":"Rui","full_name":"Faria, Rui"},{"full_name":"Fragata, Inês","first_name":"Inês","last_name":"Fragata"},{"full_name":"Gilbert, Kimberly J.","last_name":"Gilbert","first_name":"Kimberly J."},{"full_name":"Jay, Paul","last_name":"Jay","first_name":"Paul"},{"full_name":"Kapun, Martin","first_name":"Martin","last_name":"Kapun"},{"full_name":"Lotterhos, Katie E.","first_name":"Katie E.","last_name":"Lotterhos"},{"first_name":"Claire","last_name":"Mérot","full_name":"Mérot, Claire"},{"last_name":"Durmaz Mitchell","first_name":"Esra","full_name":"Durmaz Mitchell, Esra"},{"full_name":"Pascual, Marta","last_name":"Pascual","first_name":"Marta"},{"full_name":"Peichel, Catherine L.","last_name":"Peichel","first_name":"Catherine L."},{"full_name":"Rafajlović, Marina","last_name":"Rafajlović","first_name":"Marina"},{"orcid":"0000-0003-1050-4969","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M","first_name":"Anja M","last_name":"Westram"},{"full_name":"Schaeffer, Stephen W.","last_name":"Schaeffer","first_name":"Stephen W."},{"last_name":"Johannesson","first_name":"Kerstin","full_name":"Johannesson, Kerstin"},{"last_name":"Flatt","first_name":"Thomas","full_name":"Flatt, Thomas"}]},{"external_id":{"isi":["000849851100002"],"pmid":["36063156"]},"status":"public","related_material":{"record":[{"relation":"other","id":"12265","status":"public"}]},"intvolume":"        35","citation":{"apa":"Westram, A. M., Stankowski, S., Surendranadh, P., &#38; Barton, N. H. (2022). What is reproductive isolation? <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.14005\">https://doi.org/10.1111/jeb.14005</a>","ista":"Westram AM, Stankowski S, Surendranadh P, Barton NH. 2022. What is reproductive isolation? Journal of Evolutionary Biology. 35(9), 1143–1164.","mla":"Westram, Anja M., et al. “What Is Reproductive Isolation?” <i>Journal of Evolutionary Biology</i>, vol. 35, no. 9, Wiley, 2022, pp. 1143–64, doi:<a href=\"https://doi.org/10.1111/jeb.14005\">10.1111/jeb.14005</a>.","ama":"Westram AM, Stankowski S, Surendranadh P, Barton NH. What is reproductive isolation? <i>Journal of Evolutionary Biology</i>. 2022;35(9):1143-1164. doi:<a href=\"https://doi.org/10.1111/jeb.14005\">10.1111/jeb.14005</a>","short":"A.M. Westram, S. Stankowski, P. Surendranadh, N.H. Barton, Journal of Evolutionary Biology 35 (2022) 1143–1164.","chicago":"Westram, Anja M, Sean Stankowski, Parvathy Surendranadh, and Nicholas H Barton. “What Is Reproductive Isolation?” <i>Journal of Evolutionary Biology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/jeb.14005\">https://doi.org/10.1111/jeb.14005</a>.","ieee":"A. M. Westram, S. Stankowski, P. Surendranadh, and N. H. Barton, “What is reproductive isolation?,” <i>Journal of Evolutionary Biology</i>, vol. 35, no. 9. Wiley, pp. 1143–1164, 2022."},"oa":1,"publication_status":"published","has_accepted_license":"1","ddc":["570"],"date_published":"2022-09-01T00:00:00Z","acknowledgement":"We are grateful to the participants of the ESEB satellite symposium ‘Understanding reproductive isolation: bridging conceptual barriers in  speciation  research’  in  2021  for  the  interesting  discussions  that  helped  us  clarify  the  thoughts  presented  in  this  article.  We  thank  Roger Butlin, Michael Turelli and two anonymous reviewers for their thoughtful comments on this manuscript. We are also very grateful to Roger Butlin and the Barton Group for the continued conversa-tions about RI. In addition, we thank all participants of the speciation survey. Part of this work was funded by the Austrian Science Fund FWF (grant P 32166)","year":"2022","_id":"12264","page":"1143-1164","month":"09","oa_version":"Published Version","type":"journal_article","date_updated":"2023-08-04T09:53:40Z","abstract":[{"text":"Reproductive isolation (RI) is a core concept in evolutionary biology. It has been the central focus of speciation research since the modern synthesis and is the basis by which biological species are defined. Despite this, the term is used in seemingly different ways, and attempts to quantify RI have used very different approaches. After showing that the field lacks a clear definition of the term, we attempt to clarify key issues, including what RI is, how it can be quantified in principle, and how it can be measured in practice. Following other definitions with a genetic focus, we propose that RI is a quantitative measure of the effect that genetic differences between populations have on gene flow. Specifically, RI compares the flow of neutral alleles in the presence of these genetic differences to the flow without any such differences. RI is thus greater than zero when genetic differences between populations reduce the flow of neutral alleles between populations. We show how RI can be quantified in a range of scenarios. A key conclusion is that RI depends strongly on circumstances—including the spatial, temporal and genomic context—making it difficult to compare across systems. After reviewing methods for estimating RI from data, we conclude that it is difficult to measure in practice. We discuss our findings in light of the goals of speciation research and encourage the use of methods for estimating RI that integrate organismal and genetic approaches.","lang":"eng"}],"volume":35,"date_created":"2023-01-16T09:59:24Z","file_date_updated":"2023-01-30T10:05:31Z","project":[{"_id":"05959E1C-7A3F-11EA-A408-12923DDC885E","name":"The maintenance of alternative adaptive peaks in snapdragons","grant_number":"P32166"}],"keyword":["Ecology","Evolution","Behavior and Systematics"],"isi":1,"issue":"9","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1420-9101"],"issn":["1010-061X"]},"doi":"10.1111/jeb.14005","quality_controlled":"1","publisher":"Wiley","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"NiBa"}],"pmid":1,"publication":"Journal of Evolutionary Biology","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"review","scopus_import":"1","article_processing_charge":"Yes (via OA deal)","author":[{"orcid":"0000-0003-1050-4969","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M","first_name":"Anja M","last_name":"Westram"},{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","last_name":"Stankowski","first_name":"Sean"},{"id":"455235B8-F248-11E8-B48F-1D18A9856A87","full_name":"Surendranadh, Parvathy","last_name":"Surendranadh","first_name":"Parvathy"},{"first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"day":"01","file":[{"file_name":"2022_JourEvoBiology_Westram.pdf","success":1,"file_size":3146793,"content_type":"application/pdf","relation":"main_file","creator":"dernst","file_id":"12448","date_updated":"2023-01-30T10:05:31Z","checksum":"f08de57112330a7ee88d2e1b20576a1e","date_created":"2023-01-30T10:05:31Z","access_level":"open_access"}],"title":"What is reproductive isolation?"},{"_id":"12265","year":"2022","acknowledgement":"We  are  very  grateful  to  the  authors  of  the  commentaries  for  the  interesting discussion and to Luke Holman for handling this set of manuscripts. Part of this work was funded by the Austrian Science Fund FWF (grant P 32166).","date_created":"2023-01-16T09:59:37Z","file_date_updated":"2023-01-30T10:14:09Z","volume":35,"oa_version":"Published Version","month":"09","type":"journal_article","date_updated":"2023-08-04T09:53:41Z","page":"1200-1205","citation":{"ama":"Westram AM, Stankowski S, Surendranadh P, Barton NH. Reproductive isolation, speciation, and the value of disagreement: A reply to the commentaries on ‘What is reproductive isolation?’ <i>Journal of Evolutionary Biology</i>. 2022;35(9):1200-1205. doi:<a href=\"https://doi.org/10.1111/jeb.14082\">10.1111/jeb.14082</a>","mla":"Westram, Anja M., et al. “Reproductive Isolation, Speciation, and the Value of Disagreement: A Reply to the Commentaries on ‘What Is Reproductive Isolation?’” <i>Journal of Evolutionary Biology</i>, vol. 35, no. 9, Wiley, 2022, pp. 1200–05, doi:<a href=\"https://doi.org/10.1111/jeb.14082\">10.1111/jeb.14082</a>.","ista":"Westram AM, Stankowski S, Surendranadh P, Barton NH. 2022. Reproductive isolation, speciation, and the value of disagreement: A reply to the commentaries on ‘What is reproductive isolation?’ Journal of Evolutionary Biology. 35(9), 1200–1205.","apa":"Westram, A. M., Stankowski, S., Surendranadh, P., &#38; Barton, N. H. (2022). Reproductive isolation, speciation, and the value of disagreement: A reply to the commentaries on ‘What is reproductive isolation?’ <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.14082\">https://doi.org/10.1111/jeb.14082</a>","ieee":"A. M. Westram, S. Stankowski, P. Surendranadh, and N. H. Barton, “Reproductive isolation, speciation, and the value of disagreement: A reply to the commentaries on ‘What is reproductive isolation?,’” <i>Journal of Evolutionary Biology</i>, vol. 35, no. 9. Wiley, pp. 1200–1205, 2022.","chicago":"Westram, Anja M, Sean Stankowski, Parvathy Surendranadh, and Nicholas H Barton. “Reproductive Isolation, Speciation, and the Value of Disagreement: A Reply to the Commentaries on ‘What Is Reproductive Isolation?’” <i>Journal of Evolutionary Biology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/jeb.14082\">https://doi.org/10.1111/jeb.14082</a>.","short":"A.M. Westram, S. Stankowski, P. Surendranadh, N.H. Barton, Journal of Evolutionary Biology 35 (2022) 1200–1205."},"intvolume":"        35","related_material":{"record":[{"status":"public","id":"12264","relation":"other"}]},"external_id":{"isi":["000849851100009"]},"status":"public","date_published":"2022-09-01T00:00:00Z","ddc":["570"],"has_accepted_license":"1","publication_status":"published","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"letter_note","scopus_import":"1","article_processing_charge":"Yes (via OA deal)","publication":"Journal of Evolutionary Biology","department":[{"_id":"NiBa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Wiley","title":"Reproductive isolation, speciation, and the value of disagreement: A reply to the commentaries on ‘What is reproductive isolation?’","day":"01","file":[{"access_level":"open_access","date_created":"2023-01-30T10:14:09Z","checksum":"27268009e5eec030bc10667a4ac5ed4c","file_id":"12449","date_updated":"2023-01-30T10:14:09Z","creator":"dernst","file_size":349603,"content_type":"application/pdf","relation":"main_file","file_name":"2022_JourEvoBiology_Westram_Response.pdf","success":1}],"author":[{"first_name":"Anja M","last_name":"Westram","orcid":"0000-0003-1050-4969","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M"},{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean","last_name":"Stankowski"},{"first_name":"Parvathy","last_name":"Surendranadh","full_name":"Surendranadh, Parvathy","id":"455235B8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"}],"issue":"9","language":[{"iso":"eng"}],"keyword":["Ecology","Evolution","Behavior and Systematics"],"isi":1,"project":[{"name":"The maintenance of alternative adaptive peaks in snapdragons","_id":"05959E1C-7A3F-11EA-A408-12923DDC885E","grant_number":"P32166"}],"quality_controlled":"1","doi":"10.1111/jeb.14082","publication_identifier":{"eissn":["1420-9101"],"issn":["1010-061X"]}},{"abstract":[{"lang":"eng","text":"Insects are exposed to a variety of potential pathogens in their environment, many of which can severely impact fitness and health. Consequently, hosts have evolved resistance and tolerance strategies to suppress or cope with infections. Hosts utilizing resistance improve fitness by clearing or reducing pathogen loads, and hosts utilizing tolerance reduce harmful fitness effects per pathogen load. To understand variation in, and selective pressures on, resistance and tolerance, we asked to what degree they are shaped by host genetic background, whether plasticity in these responses depends upon dietary environment, and whether there are interactions between these two factors. Females from ten wild-type Drosophila melanogaster genotypes were kept on high- or low-protein (yeast) diets and infected with one of two opportunistic bacterial pathogens, Lactococcus lactis or Pseudomonas entomophila. We measured host resistance as the inverse of bacterial load in the early infection phase. The relationship (slope) between fly fecundity and individual-level bacteria load provided our fecundity tolerance measure. Genotype and dietary yeast determined host fecundity and strongly affected survival after infection with pathogenic P. entomophila. There was considerable genetic variation in host resistance, a commonly found phenomenon resulting from for example varying resistance costs or frequency-dependent selection. Despite this variation and the reproductive cost of higher P. entomophila loads, fecundity tolerance did not vary across genotypes. The absence of genetic variation in tolerance may suggest that at this early infection stage, fecundity tolerance is fixed or that any evolved tolerance mechanisms are not expressed under these infection conditions."}],"date_updated":"2023-09-11T14:06:04Z","oa_version":"Published Version","type":"journal_article","month":"01","page":"159  - 171","date_created":"2018-12-11T11:47:31Z","volume":31,"year":"2018","acknowledgement":"We would like to thank Susann Wicke for performing the genome-wide SNP/indel analyses, as well as Veronica Alves, Kevin Ferro, Momir Futo, Barbara Hasert, Dafne Maximo, Nora Schulz, Marlene Sroka, and Barth Wieczorek for technical help. We thank Brian Lazzaro for the L. lactis strain and Bruno Lemaitre for the Pseudomonas entomophila strain. We would like to thank two anonymous reviewers for their helpful comments. We are grateful to the Deutsche Forschungsgemeinschaft (DFG) priority programme 1399 ‘Host parasite coevolution’ for funding this project (AR 872/1-1). ","_id":"617","oa":1,"publication_status":"published","main_file_link":[{"url":"https://doi.org/10.1111/jeb.13211","open_access":"1"}],"date_published":"2018-01-01T00:00:00Z","status":"public","external_id":{"isi":["000419307000014"],"pmid":["29150962"]},"citation":{"chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie Armitage. “Genotype and Diet Affect Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” <i>Journal of Evolutionary Biology</i>. Wiley, 2018. <a href=\"https://doi.org/10.1111/jeb.13211\">https://doi.org/10.1111/jeb.13211</a>.","ieee":"M. Kutzer, J. Kurtz, and S. Armitage, “Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance,” <i>Journal of Evolutionary Biology</i>, vol. 31, no. 1. Wiley, pp. 159–171, 2018.","short":"M. Kutzer, J. Kurtz, S. Armitage, Journal of Evolutionary Biology 31 (2018) 159–171.","ama":"Kutzer M, Kurtz J, Armitage S. Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance. <i>Journal of Evolutionary Biology</i>. 2018;31(1):159-171. doi:<a href=\"https://doi.org/10.1111/jeb.13211\">10.1111/jeb.13211</a>","apa":"Kutzer, M., Kurtz, J., &#38; Armitage, S. (2018). Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance. <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.13211\">https://doi.org/10.1111/jeb.13211</a>","ista":"Kutzer M, Kurtz J, Armitage S. 2018. Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology. 31(1), 159–171.","mla":"Kutzer, Megan, et al. “Genotype and Diet Affect Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” <i>Journal of Evolutionary Biology</i>, vol. 31, no. 1, Wiley, 2018, pp. 159–71, doi:<a href=\"https://doi.org/10.1111/jeb.13211\">10.1111/jeb.13211</a>."},"intvolume":"        31","day":"01","author":[{"last_name":"Kutzer","first_name":"Megan","orcid":"0000-0002-8696-6978","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","full_name":"Kutzer, Megan"},{"full_name":"Kurtz, Joachim","first_name":"Joachim","last_name":"Kurtz"},{"full_name":"Armitage, Sophie","first_name":"Sophie","last_name":"Armitage"}],"publist_id":"7187","title":"Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance","pmid":1,"department":[{"_id":"SyCr"}],"publisher":"Wiley","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","scopus_import":"1","article_processing_charge":"No","article_type":"original","publication":"Journal of Evolutionary Biology","publication_identifier":{"eissn":["1420-9101"],"issn":["1010-061X"]},"quality_controlled":"1","doi":"10.1111/jeb.13211","language":[{"iso":"eng"}],"issue":"1","isi":1},{"citation":{"short":"M. Tobler, M. Plath, R. Riesch, I. Schlupp, A.V. Grasse, G. Munimanda, C. Setzer, D. Penn, Y. Moodley, Journal of Evolutionary Biology 27 (2014) 960–974.","chicago":"Tobler, Michael, Martin Plath, Rüdiger Riesch, Ingo Schlupp, Anna V Grasse, Gopi Munimanda, C Setzer, Dustin Penn, and Yoshan Moodley. “Selection from Parasites Favours Immunogenetic Diversity but Not Divergence among Locally Adapted Host Populations.” <i>Journal of Evolutionary Biology</i>. Wiley, 2014. <a href=\"https://doi.org/10.1111/jeb.12370\">https://doi.org/10.1111/jeb.12370</a>.","ieee":"M. Tobler <i>et al.</i>, “Selection from parasites favours immunogenetic diversity but not divergence among locally adapted host populations,” <i>Journal of Evolutionary Biology</i>, vol. 27, no. 5. Wiley, pp. 960–974, 2014.","apa":"Tobler, M., Plath, M., Riesch, R., Schlupp, I., Grasse, A. V., Munimanda, G., … Moodley, Y. (2014). Selection from parasites favours immunogenetic diversity but not divergence among locally adapted host populations. <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.12370\">https://doi.org/10.1111/jeb.12370</a>","mla":"Tobler, Michael, et al. “Selection from Parasites Favours Immunogenetic Diversity but Not Divergence among Locally Adapted Host Populations.” <i>Journal of Evolutionary Biology</i>, vol. 27, no. 5, Wiley, 2014, pp. 960–74, doi:<a href=\"https://doi.org/10.1111/jeb.12370\">10.1111/jeb.12370</a>.","ista":"Tobler M, Plath M, Riesch R, Schlupp I, Grasse AV, Munimanda G, Setzer C, Penn D, Moodley Y. 2014. Selection from parasites favours immunogenetic diversity but not divergence among locally adapted host populations. Journal of Evolutionary Biology. 27(5), 960–974.","ama":"Tobler M, Plath M, Riesch R, et al. Selection from parasites favours immunogenetic diversity but not divergence among locally adapted host populations. <i>Journal of Evolutionary Biology</i>. 2014;27(5):960-974. doi:<a href=\"https://doi.org/10.1111/jeb.12370\">10.1111/jeb.12370</a>"},"intvolume":"        27","status":"public","external_id":{"pmid":["24725091"]},"date_published":"2014-04-12T00:00:00Z","publication_status":"published","_id":"1905","year":"2014","acknowledgement":"This study was funded by grants from the National Science Foundation (NSF) to MT (IOS-1121832) and IS (DEB-0743406) and from the German Science Foundation (DFG; PL 470/1-2) and ‘LOEWE − Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz’ of Hesse's Ministry of Higher Education, Research, and the Arts, to MP.","date_created":"2018-12-11T11:54:38Z","volume":27,"abstract":[{"text":"The unprecedented polymorphism in the major histocompatibility complex (MHC) genes is thought to be maintained by balancing selection from parasites. However, do parasites also drive divergence at MHC loci between host populations, or do the effects of balancing selection maintain similarities among populations? We examined MHC variation in populations of the livebearing fish Poecilia mexicana and characterized their parasite communities. Poecilia mexicana populations in the Cueva del Azufre system are locally adapted to darkness and the presence of toxic hydrogen sulphide, representing highly divergent ecotypes or incipient species. Parasite communities differed significantly across populations, and populations with higher parasite loads had higher levels of diversity at class II MHC genes. However, despite different parasite communities, marked divergence in adaptive traits and in neutral genetic markers, we found MHC alleles to be remarkably similar among host populations. Our findings indicate that balancing selection from parasites maintains immunogenetic diversity of hosts, but this process does not promote MHC divergence in this system. On the contrary, we suggest that balancing selection on immunogenetic loci may outweigh divergent selection causing divergence, thereby hindering host divergence and speciation. Our findings support the hypothesis that balancing selection maintains MHC similarities among lineages during and after speciation (trans-species evolution).","lang":"eng"}],"date_updated":"2022-06-07T09:22:20Z","oa_version":"None","month":"04","type":"journal_article","page":"960 - 974","language":[{"iso":"eng"}],"issue":"5","quality_controlled":"1","doi":"10.1111/jeb.12370","publication_identifier":{"eissn":["1420-9101"],"issn":["1010-061X"]},"scopus_import":"1","article_processing_charge":"No","article_type":"original","publication":"Journal of Evolutionary Biology","pmid":1,"department":[{"_id":"SyCr"}],"publisher":"Wiley","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"5190","title":"Selection from parasites favours immunogenetic diversity but not divergence among locally adapted host populations","day":"12","author":[{"full_name":"Tobler, Michael","first_name":"Michael","last_name":"Tobler"},{"full_name":"Plath, Martin","last_name":"Plath","first_name":"Martin"},{"first_name":"Rüdiger","last_name":"Riesch","full_name":"Riesch, Rüdiger"},{"full_name":"Schlupp, Ingo","last_name":"Schlupp","first_name":"Ingo"},{"first_name":"Anna V","last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V"},{"full_name":"Munimanda, Gopi","last_name":"Munimanda","first_name":"Gopi"},{"full_name":"Setzer, C","last_name":"Setzer","first_name":"C"},{"full_name":"Penn, Dustin","first_name":"Dustin","last_name":"Penn"},{"full_name":"Moodley, Yoshan","first_name":"Yoshan","last_name":"Moodley"}]}]