---
_id: '14843'
abstract:
- lang: eng
  text: The coupling between Ca2+ channels and release sensors is a key factor defining
    the signaling properties of a synapse. However, the coupling nanotopography at
    many synapses remains unknown, and it is unclear how it changes during development.
    To address these questions, we examined coupling at the cerebellar inhibitory
    basket cell (BC)-Purkinje cell (PC) synapse. Biophysical analysis of transmission
    by paired recording and intracellular pipette perfusion revealed that the effects
    of exogenous Ca2+ chelators decreased during development, despite constant reliance
    of release on P/Q-type Ca2+ channels. Structural analysis by freeze-fracture replica
    labeling (FRL) and transmission electron microscopy (EM) indicated that presynaptic
    P/Q-type Ca2+ channels formed nanoclusters throughout development, whereas docked
    vesicles were only clustered at later developmental stages. Modeling suggested
    a developmental transformation from a more random to a more clustered coupling
    nanotopography. Thus, presynaptic signaling developmentally approaches a point-to-point
    configuration, optimizing speed, reliability, and energy efficiency of synaptic
    transmission.
acknowledged_ssus:
- _id: EM-Fac
- _id: PreCl
- _id: M-Shop
acknowledgement: We thank Drs. David DiGregorio and Erwin Neher for critically reading
  an earlier version of the manuscript, Ralf Schneggenburger for helpful discussions,
  Benjamin Suter and Katharina Lichter for support with image analysis, Chris Wojtan
  for advice on numerical solution of partial differential equations, Maria Reva for
  help with Ripley analysis, Alois Schlögl for programming, and Akari Hagiwara and
  Toshihisa Ohtsuka for anti-ELKS antibody. We are grateful to Florian Marr, Christina
  Altmutter, and Vanessa Zheden for excellent technical assistance and to Eleftheria
  Kralli-Beller for manuscript editing. This research was supported by the Scientific
  Services Units (SSUs) of ISTA (Electron Microscopy Facility, Preclinical Facility,
  and Machine Shop). The project received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation program (grant
  agreement no. 692692), the Fonds zur Förderung der Wissenschaftlichen Forschung
  (Z 312-B27, Wittgenstein award; P 36232-B), all to P.J., and a DOC fellowship of
  the Austrian Academy of Sciences to J.-J.C.
article_processing_charge: No
article_type: original
author:
- first_name: JingJing
  full_name: Chen, JingJing
  id: 2C4E65C8-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Walter
  full_name: Kaufmann, Walter
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- first_name: Chong
  full_name: Chen, Chong
  id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Itaru
  full_name: Arai, Itaru
  id: 32A73F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Arai
- first_name: Olena
  full_name: Kim, Olena
  id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Chen J, Kaufmann W, Chen C, et al. Developmental transformation of Ca2+ channel-vesicle
    nanotopography at a central GABAergic synapse. <i>Neuron</i>. doi:<a href="https://doi.org/10.1016/j.neuron.2023.12.002">10.1016/j.neuron.2023.12.002</a>
  apa: Chen, J., Kaufmann, W., Chen, C., Arai,  itaru, Kim, O., Shigemoto, R., &#38;
    Jonas, P. M. (n.d.). Developmental transformation of Ca2+ channel-vesicle nanotopography
    at a central GABAergic synapse. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2023.12.002">https://doi.org/10.1016/j.neuron.2023.12.002</a>
  chicago: Chen, JingJing, Walter Kaufmann, Chong Chen, itaru Arai, Olena Kim, Ryuichi
    Shigemoto, and Peter M Jonas. “Developmental Transformation of Ca2+ Channel-Vesicle
    Nanotopography at a Central GABAergic Synapse.” <i>Neuron</i>. Elsevier, n.d.
    <a href="https://doi.org/10.1016/j.neuron.2023.12.002">https://doi.org/10.1016/j.neuron.2023.12.002</a>.
  ieee: J. Chen <i>et al.</i>, “Developmental transformation of Ca2+ channel-vesicle
    nanotopography at a central GABAergic synapse,” <i>Neuron</i>. Elsevier.
  ista: Chen J, Kaufmann W, Chen C, Arai  itaru, Kim O, Shigemoto R, Jonas PM. Developmental
    transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse.
    Neuron.
  mla: Chen, JingJing, et al. “Developmental Transformation of Ca2+ Channel-Vesicle
    Nanotopography at a Central GABAergic Synapse.” <i>Neuron</i>, Elsevier, doi:<a
    href="https://doi.org/10.1016/j.neuron.2023.12.002">10.1016/j.neuron.2023.12.002</a>.
  short: J. Chen, W. Kaufmann, C. Chen,  itaru Arai, O. Kim, R. Shigemoto, P.M. Jonas,
    Neuron (n.d.).
date_created: 2024-01-21T23:00:56Z
date_published: 2024-01-11T00:00:00Z
date_updated: 2024-03-05T09:31:24Z
day: '11'
department:
- _id: PeJo
- _id: EM-Fac
- _id: RySh
doi: 10.1016/j.neuron.2023.12.002
ec_funded: 1
external_id:
  pmid:
  - '38215739'
language:
- iso: eng
month: '01'
oa_version: None
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: The Wittgenstein Prize
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
  grant_number: P36232
  name: Mechanisms of GABA release in hippocampal circuits
- _id: 26B66A3E-B435-11E9-9278-68D0E5697425
  grant_number: '25383'
  name: Development of nanodomain coupling between Ca2+ channels and release sensors
    at a central inhibitory synapse
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
  issn:
  - 0896-6273
publication_status: inpress
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA Website
    relation: press_release
    url: https://ista.ac.at/en/news/synapses-brought-to-the-point/
scopus_import: '1'
status: public
title: Developmental transformation of Ca2+ channel-vesicle nanotopography at a central
  GABAergic synapse
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '12542'
abstract:
- lang: eng
  text: In this issue of Neuron, Espinosa-Medina et al.1 present the TEMPO (Temporal
    Encoding and Manipulation in a Predefined Order) system, which enables the marking
    and genetic manipulation of sequentially generated cell lineages in vertebrate
    species in vivo.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Villalba Requena A, Hippenmeyer S. Going back in time with TEMPO. <i>Neuron</i>.
    2023;111(3):291-293. doi:<a href="https://doi.org/10.1016/j.neuron.2023.01.006">10.1016/j.neuron.2023.01.006</a>
  apa: Villalba Requena, A., &#38; Hippenmeyer, S. (2023). Going back in time with
    TEMPO. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2023.01.006">https://doi.org/10.1016/j.neuron.2023.01.006</a>
  chicago: Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with
    TEMPO.” <i>Neuron</i>. Elsevier, 2023. <a href="https://doi.org/10.1016/j.neuron.2023.01.006">https://doi.org/10.1016/j.neuron.2023.01.006</a>.
  ieee: A. Villalba Requena and S. Hippenmeyer, “Going back in time with TEMPO,” <i>Neuron</i>,
    vol. 111, no. 3. Elsevier, pp. 291–293, 2023.
  ista: Villalba Requena A, Hippenmeyer S. 2023. Going back in time with TEMPO. Neuron.
    111(3), 291–293.
  mla: Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with TEMPO.”
    <i>Neuron</i>, vol. 111, no. 3, Elsevier, 2023, pp. 291–93, doi:<a href="https://doi.org/10.1016/j.neuron.2023.01.006">10.1016/j.neuron.2023.01.006</a>.
  short: A. Villalba Requena, S. Hippenmeyer, Neuron 111 (2023) 291–293.
date_created: 2023-02-12T23:00:58Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-08-01T13:10:27Z
day: '01'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2023.01.006
external_id:
  isi:
  - '000994473300001'
intvolume: '       111'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 291-293
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Going back in time with TEMPO
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 111
year: '2023'
...
---
_id: '10753'
abstract:
- lang: eng
  text: This is a comment on "Meta-learning synaptic plasticity and memory addressing
    for continual familiarity detection." Neuron. 2022 Feb 2;110(3):544-557.e8.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Basile J
  full_name: Confavreux, Basile J
  id: C7610134-B532-11EA-BD9F-F5753DDC885E
  last_name: Confavreux
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
citation:
  ama: 'Confavreux BJ, Vogels TP. A familiar thought: Machines that replace us? <i>Neuron</i>.
    2022;110(3):361-362. doi:<a href="https://doi.org/10.1016/j.neuron.2022.01.014">10.1016/j.neuron.2022.01.014</a>'
  apa: 'Confavreux, B. J., &#38; Vogels, T. P. (2022). A familiar thought: Machines
    that replace us? <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2022.01.014">https://doi.org/10.1016/j.neuron.2022.01.014</a>'
  chicago: 'Confavreux, Basile J, and Tim P Vogels. “A Familiar Thought: Machines
    That Replace Us?” <i>Neuron</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.neuron.2022.01.014">https://doi.org/10.1016/j.neuron.2022.01.014</a>.'
  ieee: 'B. J. Confavreux and T. P. Vogels, “A familiar thought: Machines that replace
    us?,” <i>Neuron</i>, vol. 110, no. 3. Elsevier, pp. 361–362, 2022.'
  ista: 'Confavreux BJ, Vogels TP. 2022. A familiar thought: Machines that replace
    us? Neuron. 110(3), 361–362.'
  mla: 'Confavreux, Basile J., and Tim P. Vogels. “A Familiar Thought: Machines That
    Replace Us?” <i>Neuron</i>, vol. 110, no. 3, Elsevier, 2022, pp. 361–62, doi:<a
    href="https://doi.org/10.1016/j.neuron.2022.01.014">10.1016/j.neuron.2022.01.014</a>.'
  short: B.J. Confavreux, T.P. Vogels, Neuron 110 (2022) 361–362.
date_created: 2022-02-13T23:01:34Z
date_published: 2022-02-02T00:00:00Z
date_updated: 2023-10-03T10:53:17Z
day: '02'
department:
- _id: TiVo
doi: 10.1016/j.neuron.2022.01.014
external_id:
  isi:
  - '000751819100005'
  pmid:
  - '35114107'
intvolume: '       110'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2022.01.014
month: '02'
oa: 1
oa_version: Published Version
page: 361-362
pmid: 1
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A familiar thought: Machines that replace us?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 110
year: '2022'
...
---
_id: '8544'
abstract:
- lang: eng
  text: The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic
    branches, yet this hypothesis has not been causally tested in vivo in the mammalian
    brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2
    mediate synaptogenesis between granule cells and Purkinje cells in the molecular
    layer of the cerebellar cortex. Here we show that sparse but not global knockout
    of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular
    layer and overelaboration in the superficial molecular layer. Developmental, overexpression,
    structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis
    defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner.
    A generative model of dendritic growth based on competitive synaptogenesis largely
    recapitulates GluD2 sparse and global knockout phenotypes. Our results support
    the synaptotrophic hypothesis at initial stages of dendrite development, suggest
    a second mode in which cumulative synapse formation inhibits further dendrite
    growth, and highlight the importance of competition in dendrite morphogenesis.
acknowledgement: We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I.
  Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W.
  Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members
  of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin,
  D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript,
  and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T.
  was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate
  Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate
  Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs
  Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538)
  to L.L.; the European Research Council (ERC) under the European Union's Horizon
  2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons
  and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI
  investigator.
article_processing_charge: No
article_type: original
author:
- first_name: Yukari H.
  full_name: Takeo, Yukari H.
  last_name: Takeo
- first_name: S. Andrew
  full_name: Shuster, S. Andrew
  last_name: Shuster
- first_name: Linnie
  full_name: Jiang, Linnie
  last_name: Jiang
- first_name: Miley
  full_name: Hu, Miley
  last_name: Hu
- first_name: David J.
  full_name: Luginbuhl, David J.
  last_name: Luginbuhl
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Ximena
  full_name: Contreras, Ximena
  id: 475990FE-F248-11E8-B48F-1D18A9856A87
  last_name: Contreras
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Mark J.
  full_name: Wagner, Mark J.
  last_name: Wagner
- first_name: Surya
  full_name: Ganguli, Surya
  last_name: Ganguli
- first_name: Liqun
  full_name: Luo, Liqun
  last_name: Luo
citation:
  ama: Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive
    synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. <i>Neuron</i>.
    2021;109(4):P629-644.E8. doi:<a href="https://doi.org/10.1016/j.neuron.2020.11.028">10.1016/j.neuron.2020.11.028</a>
  apa: Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke,
    T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes
    the dendritic arbors of cerebellar Purkinje cells. <i>Neuron</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.neuron.2020.11.028">https://doi.org/10.1016/j.neuron.2020.11.028</a>
  chicago: Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl,
    Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive
    Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” <i>Neuron</i>.
    Elsevier, 2021. <a href="https://doi.org/10.1016/j.neuron.2020.11.028">https://doi.org/10.1016/j.neuron.2020.11.028</a>.
  ieee: Y. H. Takeo <i>et al.</i>, “GluD2- and Cbln1-mediated competitive synaptogenesis
    shapes the dendritic arbors of cerebellar Purkinje cells,” <i>Neuron</i>, vol.
    109, no. 4. Elsevier, p. P629–644.E8, 2021.
  ista: Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X,
    Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive
    synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
    109(4), P629–644.E8.
  mla: Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis
    Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” <i>Neuron</i>, vol.
    109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:<a href="https://doi.org/10.1016/j.neuron.2020.11.028">10.1016/j.neuron.2020.11.028</a>.
  short: Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X.
    Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021)
    P629–644.E8.
date_created: 2020-09-21T11:59:47Z
date_published: 2021-02-17T00:00:00Z
date_updated: 2024-03-06T12:12:48Z
day: '17'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2020.11.028
ec_funded: 1
intvolume: '       109'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2020.06.14.151258
month: '02'
oa: 1
oa_version: Preprint
page: P629-644.E8
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors
  of cerebellar Purkinje cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 109
year: '2021'
...
---
_id: '9793'
abstract:
- lang: eng
  text: Astrocytes extensively infiltrate the neuropil to regulate critical aspects
    of synaptic development and function. This process is regulated by transcellular
    interactions between astrocytes and neurons via cell adhesion molecules. How astrocytes
    coordinate developmental processes among one another to parse out the synaptic
    neuropil and form non-overlapping territories is unknown. Here we identify a molecular
    mechanism regulating astrocyte-astrocyte interactions during development to coordinate
    astrocyte morphogenesis and gap junction coupling. We show that hepaCAM, a disease-linked,
    astrocyte-enriched cell adhesion molecule, regulates astrocyte competition for
    territory and morphological complexity in the developing mouse cortex. Furthermore,
    conditional deletion of Hepacam from developing astrocytes significantly impairs
    gap junction coupling between astrocytes and disrupts the balance between synaptic
    excitation and inhibition. Mutations in HEPACAM cause megalencephalic leukoencephalopathy
    with subcortical cysts in humans. Therefore, our findings suggest that disruption
    of astrocyte self-organization mechanisms could be an underlying cause of neural
    pathology.
acknowledgement: This work was supported by the National Institutes of Health (R01
  DA047258 and R01 NS102237 to C.E., F32 NS100392 to K.T.B.) and the Holland-Trice
  Brain Research Award (to C.E.). K.T.B. was supported by postdoctoral fellowships
  from the Foerster-Bernstein Family and The Hartwell Foundation. The Hippenmeyer
  lab was supported by the European Research Council (ERC) under the European Union’s
  Horizon 2020 research and innovations program (725780 LinPro) to S.H. R.E. was supported
  by Ministerio de Ciencia y Tecnología (RTI2018-093493-B-I00). We thank the Duke
  Light Microscopy Core Facility, the Duke Transgenic Mouse Facility, Dr. U. Schulte
  for assistance with proteomic experiments, and Dr. D. Silver for critical review
  of the manuscript. Cartoon elements of figure panels were created using BioRender.com.
article_processing_charge: No
article_type: original
author:
- first_name: Katherine T.
  full_name: Baldwin, Katherine T.
  last_name: Baldwin
- first_name: Christabel X.
  full_name: Tan, Christabel X.
  last_name: Tan
- first_name: Samuel T.
  full_name: Strader, Samuel T.
  last_name: Strader
- first_name: Changyu
  full_name: Jiang, Changyu
  last_name: Jiang
- first_name: Justin T.
  full_name: Savage, Justin T.
  last_name: Savage
- first_name: Xabier
  full_name: Elorza-Vidal, Xabier
  last_name: Elorza-Vidal
- first_name: Ximena
  full_name: Contreras, Ximena
  id: 475990FE-F248-11E8-B48F-1D18A9856A87
  last_name: Contreras
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Raúl
  full_name: Estévez, Raúl
  last_name: Estévez
- first_name: Ru-Rong
  full_name: Ji, Ru-Rong
  last_name: Ji
- first_name: Cagla
  full_name: Eroglu, Cagla
  last_name: Eroglu
citation:
  ama: Baldwin KT, Tan CX, Strader ST, et al. HepaCAM controls astrocyte self-organization
    and coupling. <i>Neuron</i>. 2021;109(15):2427-2442.e10. doi:<a href="https://doi.org/10.1016/j.neuron.2021.05.025">10.1016/j.neuron.2021.05.025</a>
  apa: Baldwin, K. T., Tan, C. X., Strader, S. T., Jiang, C., Savage, J. T., Elorza-Vidal,
    X., … Eroglu, C. (2021). HepaCAM controls astrocyte self-organization and coupling.
    <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2021.05.025">https://doi.org/10.1016/j.neuron.2021.05.025</a>
  chicago: Baldwin, Katherine T., Christabel X. Tan, Samuel T. Strader, Changyu Jiang,
    Justin T. Savage, Xabier Elorza-Vidal, Ximena Contreras, et al. “HepaCAM Controls
    Astrocyte Self-Organization and Coupling.” <i>Neuron</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.neuron.2021.05.025">https://doi.org/10.1016/j.neuron.2021.05.025</a>.
  ieee: K. T. Baldwin <i>et al.</i>, “HepaCAM controls astrocyte self-organization
    and coupling,” <i>Neuron</i>, vol. 109, no. 15. Elsevier, p. 2427–2442.e10, 2021.
  ista: Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras
    X, Rülicke T, Hippenmeyer S, Estévez R, Ji R-R, Eroglu C. 2021. HepaCAM controls
    astrocyte self-organization and coupling. Neuron. 109(15), 2427–2442.e10.
  mla: Baldwin, Katherine T., et al. “HepaCAM Controls Astrocyte Self-Organization
    and Coupling.” <i>Neuron</i>, vol. 109, no. 15, Elsevier, 2021, p. 2427–2442.e10,
    doi:<a href="https://doi.org/10.1016/j.neuron.2021.05.025">10.1016/j.neuron.2021.05.025</a>.
  short: K.T. Baldwin, C.X. Tan, S.T. Strader, C. Jiang, J.T. Savage, X. Elorza-Vidal,
    X. Contreras, T. Rülicke, S. Hippenmeyer, R. Estévez, R.-R. Ji, C. Eroglu, Neuron
    109 (2021) 2427–2442.e10.
date_created: 2021-08-06T09:08:25Z
date_published: 2021-08-04T00:00:00Z
date_updated: 2023-09-27T07:46:09Z
day: '04'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2021.05.025
ec_funded: 1
external_id:
  isi:
  - '000692851900010'
  pmid:
  - '34171291'
intvolume: '       109'
isi: 1
issue: '15'
language:
- iso: eng
main_file_link:
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  url: https://doi.org/10.1016/j.neuron.2021.05.025
month: '08'
oa: 1
oa_version: Published Version
page: 2427-2442.e10
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: HepaCAM controls astrocyte self-organization and coupling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 109
year: '2021'
...
---
_id: '6454'
abstract:
- lang: eng
  text: 'Adult neural stem cells and multiciliated ependymalcells are glial cells
    essential for neurological func-tions. Together, they make up the adult neurogenicniche.
    Using both high-throughput clonal analysisand single-cell resolution of progenitor
    division pat-terns and fate, we show that these two componentsof the neurogenic
    niche are lineally related: adult neu-ral stem cells are sister cells to ependymal
    cells,whereas most ependymal cells arise from the termi-nal symmetric divisions
    of the lineage. Unexpectedly,we found that the antagonist regulators of DNA repli-cation,
    GemC1 and Geminin, can tune the proportionof neural stem cells and ependymal cells.
    Our find-ings reveal the controlled dynamic of the neurogenicniche ontogeny and
    identify the Geminin familymembers as key regulators of the initial pool of adultneural
    stem cells.'
article_processing_charge: No
author:
- first_name: G
  full_name: Ortiz-Álvarez, G
  last_name: Ortiz-Álvarez
- first_name: M
  full_name: Daclin, M
  last_name: Daclin
- first_name: A
  full_name: Shihavuddin, A
  last_name: Shihavuddin
- first_name: P
  full_name: Lansade, P
  last_name: Lansade
- first_name: A
  full_name: Fortoul, A
  last_name: Fortoul
- first_name: M
  full_name: Faucourt, M
  last_name: Faucourt
- first_name: S
  full_name: Clavreul, S
  last_name: Clavreul
- first_name: ME
  full_name: Lalioti, ME
  last_name: Lalioti
- first_name: S
  full_name: Taraviras, S
  last_name: Taraviras
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: J
  full_name: Livet, J
  last_name: Livet
- first_name: A
  full_name: Meunier, A
  last_name: Meunier
- first_name: A
  full_name: Genovesio, A
  last_name: Genovesio
- first_name: N
  full_name: Spassky, N
  last_name: Spassky
citation:
  ama: Ortiz-Álvarez G, Daclin M, Shihavuddin A, et al. Adult neural stem cells and
    multiciliated ependymal cells share a common lineage regulated by the Geminin
    family members. <i>Neuron</i>. 2019;102(1):159-172.e7. doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.051">10.1016/j.neuron.2019.01.051</a>
  apa: Ortiz-Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt,
    M., … Spassky, N. (2019). Adult neural stem cells and multiciliated ependymal
    cells share a common lineage regulated by the Geminin family members. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2019.01.051">https://doi.org/10.1016/j.neuron.2019.01.051</a>
  chicago: Ortiz-Álvarez, G, M Daclin, A Shihavuddin, P Lansade, A Fortoul, M Faucourt,
    S Clavreul, et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells
    Share a Common Lineage Regulated by the Geminin Family Members.” <i>Neuron</i>.
    Elsevier, 2019. <a href="https://doi.org/10.1016/j.neuron.2019.01.051">https://doi.org/10.1016/j.neuron.2019.01.051</a>.
  ieee: G. Ortiz-Álvarez <i>et al.</i>, “Adult neural stem cells and multiciliated
    ependymal cells share a common lineage regulated by the Geminin family members,”
    <i>Neuron</i>, vol. 102, no. 1. Elsevier, p. 159–172.e7, 2019.
  ista: Ortiz-Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M,
    Clavreul S, Lalioti M, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio
    A, Spassky N. 2019. Adult neural stem cells and multiciliated ependymal cells
    share a common lineage regulated by the Geminin family members. Neuron. 102(1),
    159–172.e7.
  mla: Ortiz-Álvarez, G., et al. “Adult Neural Stem Cells and Multiciliated Ependymal
    Cells Share a Common Lineage Regulated by the Geminin Family Members.” <i>Neuron</i>,
    vol. 102, no. 1, Elsevier, 2019, p. 159–172.e7, doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.051">10.1016/j.neuron.2019.01.051</a>.
  short: G. Ortiz-Álvarez, M. Daclin, A. Shihavuddin, P. Lansade, A. Fortoul, M. Faucourt,
    S. Clavreul, M. Lalioti, S. Taraviras, S. Hippenmeyer, J. Livet, A. Meunier, A.
    Genovesio, N. Spassky, Neuron 102 (2019) 159–172.e7.
date_created: 2019-05-14T13:06:30Z
date_published: 2019-04-03T00:00:00Z
date_updated: 2023-09-05T13:02:21Z
day: '03'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2019.01.051
ec_funded: 1
external_id:
  isi:
  - '000463337900018'
  pmid:
  - '30824354'
file:
- access_level: open_access
  checksum: 1fb6e195c583eb0c5cabf26f69ff6675
  content_type: application/pdf
  creator: dernst
  date_created: 2019-05-15T09:28:41Z
  date_updated: 2020-07-14T12:47:30Z
  file_id: '6457'
  file_name: 2019_Neuron_Ortiz.pdf
  file_size: 7288572
  relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
has_accepted_license: '1'
intvolume: '       102'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '04'
oa: 1
oa_version: Published Version
page: 159-172.e7
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adult neural stem cells and multiciliated ependymal cells share a common lineage
  regulated by the Geminin family members
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 102
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...