---
_id: '9444'
abstract:
- lang: eng
  text: Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent
    alleles) are associated with dense hypermethylation at noncanonical cytosines
    (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors
    of a hypermethylated clark kent mutant identified nine loss-of-function alleles
    of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3
    mutants display a wild-type morphology but exhibit decreased CpXpG methylation
    of the SUP gene and of other sequences throughout the genome. They also show reactivated
    expression of endogenous retrotransposon sequences. These results show that a
    non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.
article_processing_charge: No
article_type: original
author:
- first_name: A. M.
  full_name: Lindroth, A. M.
  last_name: Lindroth
- first_name: Xiaofeng
  full_name: Cao, Xiaofeng
  last_name: Cao
- first_name: James P.
  full_name: Jackson, James P.
  last_name: Jackson
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: Claire M.
  full_name: McCallum, Claire M.
  last_name: McCallum
- first_name: Steven
  full_name: Henikoff, Steven
  last_name: Henikoff
- first_name: Steven E.
  full_name: Jacobsen, Steven E.
  last_name: Jacobsen
citation:
  ama: Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for
    maintenance of CpXpG methylation. <i>Science</i>. 2001;292(5524):2077-2080. doi:<a
    href="https://doi.org/10.1126/science.1059745">10.1126/science.1059745</a>
  apa: Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff,
    S., &#38; Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance
    of CpXpG methylation. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.1059745">https://doi.org/10.1126/science.1059745</a>
  chicago: Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire
    M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3
    for Maintenance of CpXpG Methylation.” <i>Science</i>. American Association for
    the Advancement of Science, 2001. <a href="https://doi.org/10.1126/science.1059745">https://doi.org/10.1126/science.1059745</a>.
  ieee: A. M. Lindroth <i>et al.</i>, “Requirement of CHROMOMETHYLASE3 for maintenance
    of CpXpG methylation,” <i>Science</i>, vol. 292, no. 5524. American Association
    for the Advancement of Science, pp. 2077–2080, 2001.
  ista: Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen
    SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation.
    Science. 292(5524), 2077–2080.
  mla: Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of
    CpXpG Methylation.” <i>Science</i>, vol. 292, no. 5524, American Association for
    the Advancement of Science, 2001, pp. 2077–80, doi:<a href="https://doi.org/10.1126/science.1059745">10.1126/science.1059745</a>.
  short: A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff,
    S.E. Jacobsen, Science 292 (2001) 2077–2080.
date_created: 2021-06-02T13:35:16Z
date_published: 2001-06-15T00:00:00Z
date_updated: 2021-12-14T08:40:32Z
day: '15'
department:
- _id: DaZi
doi: 10.1126/science.1059745
extern: '1'
external_id:
  pmid:
  - '11349138'
intvolume: '       292'
issue: '5524'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '06'
oa_version: None
page: 2077-2080
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 292
year: '2001'
...