---
_id: '2494'
abstract:
- lang: eng
  text: 'This chapter focuses on metabotropic glutamate receptors (mGluRs). These
    receptors are linked to several intracellular signal transduction mechanisms via
    G-protein and are implicated in diverse functions of the mammalian central nervous
    system (CNS). These functions include mediation of slow excitatory and inhibitory
    responses; regulation of calcium channels, potassium channels, and non-selective
    cation channels; inhibition and facilitation of transmitter release; induction
    of long-term potentiation and long-term depression; and regulation of neuronal
    development. Functional diversity of the metabotropic glutamate receptor is reflected
    in molecular diversity of receptor subtypes. The sites of action of mGluRs are
    widely found throughout different membrane compartments of neuronal and glial
    cells. The chapter reviews the differential subcellular localization of metabotropic
    glutamate receptors in relation to transmitter release sites. Patterns of subcellular
    localization of mGluRs are different among three subgroups: group I and III mGluRs
    are mainly localized to somatodendritic and axonal domains of neurons, respectively,
    while group II mGluRs are extensively localized to both domains as well as to
    glial cell processes.'
alternative_title:
- Handbook of Chemical Neuroanatomy
article_processing_charge: No
author:
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
citation:
  ama: 'Shigemoto R, Mizuno N. Chapter III Metabotropic glutamate receptors - immunocytochemical
    and in situ hybridization analyses. In: <i>Glutamate</i>. Vol 18. Elsevier; 2000:63-98.
    doi:<a href="https://doi.org/10.1016/S0924-8196(00)80044-5">10.1016/S0924-8196(00)80044-5</a>'
  apa: Shigemoto, R., &#38; Mizuno, N. (2000). Chapter III Metabotropic glutamate
    receptors - immunocytochemical and in situ hybridization analyses. In <i>Glutamate</i>
    (Vol. 18, pp. 63–98). Elsevier. <a href="https://doi.org/10.1016/S0924-8196(00)80044-5">https://doi.org/10.1016/S0924-8196(00)80044-5</a>
  chicago: Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate
    Receptors - Immunocytochemical and in Situ Hybridization Analyses.” In <i>Glutamate</i>,
    18:63–98. Elsevier, 2000. <a href="https://doi.org/10.1016/S0924-8196(00)80044-5">https://doi.org/10.1016/S0924-8196(00)80044-5</a>.
  ieee: R. Shigemoto and N. Mizuno, “Chapter III Metabotropic glutamate receptors
    - immunocytochemical and in situ hybridization analyses,” in <i>Glutamate</i>,
    vol. 18, Elsevier, 2000, pp. 63–98.
  ista: 'Shigemoto R, Mizuno N. 2000.Chapter III Metabotropic glutamate receptors
    - immunocytochemical and in situ hybridization analyses. In: Glutamate. Handbook
    of Chemical Neuroanatomy, vol. 18, 63–98.'
  mla: Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate
    Receptors - Immunocytochemical and in Situ Hybridization Analyses.” <i>Glutamate</i>,
    vol. 18, Elsevier, 2000, pp. 63–98, doi:<a href="https://doi.org/10.1016/S0924-8196(00)80044-5">10.1016/S0924-8196(00)80044-5</a>.
  short: R. Shigemoto, N. Mizuno, in:, Glutamate, Elsevier, 2000, pp. 63–98.
date_created: 2018-12-11T11:58:00Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T12:27:40Z
day: '01'
doi: 10.1016/S0924-8196(00)80044-5
extern: '1'
intvolume: '        18'
language:
- iso: eng
month: '01'
oa_version: None
page: 63 - 98
publication: Glutamate
publication_identifier:
  eissn:
  - 0924-8196
publication_status: published
publisher: Elsevier
publist_id: '4407'
quality_controlled: '1'
status: public
title: Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ
  hybridization analyses
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '2000'
...