---
_id: '4201'
abstract:
- lang: eng
  text: In zebrafish, as in other vertebrates, an initially singular eye held within
    the neural plate has to split during morphogenesis to allow the development of
    two separated eyes. It has been suggested that anterior progression of midline
    tissue within the neural plate is involved in the bilateralization of the eye
    held. Mutations in the recently identified silberblick (slb) gene cause an incomplete
    separation of the eyes. During gastrulation and early somitogenesis, the ventral
    midline of the central nervous system (CNS) together with the underlying axial
    mesendoderm is shortened and broadened in slb embryos. While in wild-type embryos
    the ventral CNS midline extends to the anterior limit of the neural plate at the
    end of gastrulation, there is a gap between the anterior tip of the ventral CNS
    midline and the anterior edge of the neural plate in slb. To investigate the cause
    for the shortening of the ventral CNS midline in slb we determined the fate of
    labeled ventral CNS midline cells in wild-type and slb embryos at different stages
    of development. In slb, anterior migration of ventral CNS midline cells is impaired,
    which indicates that migration of these cells is needed for elongation of the
    ventral CNS midline. The anterior shortening of the ventral CNS midline in slb
    leads to medial instead of bilateral induction of optic stalks followed by a partial
    fusion of the eyes at later developmental stages. The analysis of the sIb phenotype
    indicates that anterior migration of midline cells within the neural plate is
    required for proper induction and subsequent bilateralization of an initially
    singular eye field. These findings may therefore provide a starting point in elucidating
    the role of neural plate morphogenesis in positioning of the eyes. (C) 1997 Academic
    Press.
acknowledgement: 'We thank C. Thisse and Q. Xu for the kind gift of hggl and rtk2
  cDNA, respectively. We are grateful to S. Wilson and R. Warga for many valuable
  comments on earlier versions of this manuscript. We also thank R. Geisler, D. Gilmour,
  M. Granato, I Odenthal, F. Pellegri, S. Schulte-Merker, and F. v. Eeden for critical
  reading of the manuscript. '
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Christiane
  full_name: Nüsslein Volhard, Christiane
  last_name: Nüsslein Volhard
citation:
  ama: Heisenberg C-PJ, Nüsslein Volhard C. The function of silberblick in the positioning
    of the eye anlage in the zebrafish embryo. <i>Developmental Biology</i>. 1997;184(1):85-94.
    doi:<a href="https://doi.org/10.1006/dbio.1997.8511">10.1006/dbio.1997.8511</a>
  apa: Heisenberg, C.-P. J., &#38; Nüsslein Volhard, C. (1997). The function of silberblick
    in the positioning of the eye anlage in the zebrafish embryo. <i>Developmental
    Biology</i>. Elsevier. <a href="https://doi.org/10.1006/dbio.1997.8511">https://doi.org/10.1006/dbio.1997.8511</a>
  chicago: Heisenberg, Carl-Philipp J, and Christiane Nüsslein Volhard. “The Function
    of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.”
    <i>Developmental Biology</i>. Elsevier, 1997. <a href="https://doi.org/10.1006/dbio.1997.8511">https://doi.org/10.1006/dbio.1997.8511</a>.
  ieee: C.-P. J. Heisenberg and C. Nüsslein Volhard, “The function of silberblick
    in the positioning of the eye anlage in the zebrafish embryo,” <i>Developmental
    Biology</i>, vol. 184, no. 1. Elsevier, pp. 85–94, 1997.
  ista: Heisenberg C-PJ, Nüsslein Volhard C. 1997. The function of silberblick in
    the positioning of the eye anlage in the zebrafish embryo. Developmental Biology.
    184(1), 85–94.
  mla: Heisenberg, Carl-Philipp J., and Christiane Nüsslein Volhard. “The Function
    of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.”
    <i>Developmental Biology</i>, vol. 184, no. 1, Elsevier, 1997, pp. 85–94, doi:<a
    href="https://doi.org/10.1006/dbio.1997.8511">10.1006/dbio.1997.8511</a>.
  short: C.-P.J. Heisenberg, C. Nüsslein Volhard, Developmental Biology 184 (1997)
    85–94.
date_created: 2018-12-11T12:07:33Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-18T13:54:19Z
day: '01'
doi: 10.1006/dbio.1997.8511
extern: '1'
external_id:
  pmid:
  - '9142986 '
intvolume: '       184'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0012160697985110?via%3Dihub
month: '04'
oa: 1
oa_version: Published Version
page: 85 - 94
pmid: 1
publication: Developmental Biology
publication_identifier:
  eissn:
  - 0012-1606
publication_status: published
publisher: Elsevier
publist_id: '1917'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The function of silberblick in the positioning of the eye anlage in the zebrafish
  embryo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 184
year: '1997'
...