[{"article_processing_charge":"No","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_identifier":{"issn":["2663-337X"],"isbn":[" 978-3-99078-025-1 "]},"project":[{"call_identifier":"H2020","_id":"260F1432-B435-11E9-9278-68D0E5697425","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"NanoFab"}],"date_updated":"2023-08-08T13:14:10Z","year":"2022","date_created":"2023-01-25T10:43:24Z","page":"113","file":[{"relation":"main_file","checksum":"e54a3e69b83ebf166544164afd25608e","file_size":14581024,"creator":"cchlebak","file_name":"THESIS_FINAL_FArslan_pdfa.pdf","date_created":"2023-01-25T10:52:46Z","content_type":"application/pdf","file_id":"12369","success":1,"access_level":"open_access","date_updated":"2023-01-25T10:52:46Z"}],"date_published":"2022-09-29T00:00:00Z","oa_version":"Published Version","author":[{"id":"49DA7910-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5809-9566","last_name":"Arslan","first_name":"Feyza N","full_name":"Arslan, Feyza N"}],"ddc":["570"],"publisher":"Institute of Science and Technology Austria","doi":"10.15479/at:ista:12153","type":"dissertation","file_date_updated":"2023-01-25T10:52:46Z","language":[{"iso":"eng"}],"has_accepted_license":"1","day":"29","citation":{"ama":"Arslan FN. Remodeling of E-cadherin-mediated contacts via cortical  flows. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:12153\">10.15479/at:ista:12153</a>","short":"F.N. Arslan, Remodeling of E-Cadherin-Mediated Contacts via Cortical  Flows, Institute of Science and Technology Austria, 2022.","ieee":"F. N. Arslan, “Remodeling of E-cadherin-mediated contacts via cortical  flows,” Institute of Science and Technology Austria, 2022.","mla":"Arslan, Feyza N. <i>Remodeling of E-Cadherin-Mediated Contacts via Cortical  Flows</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:12153\">10.15479/at:ista:12153</a>.","chicago":"Arslan, Feyza N. “Remodeling of E-Cadherin-Mediated Contacts via Cortical  Flows.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:12153\">https://doi.org/10.15479/at:ista:12153</a>.","ista":"Arslan FN. 2022. Remodeling of E-cadherin-mediated contacts via cortical  flows. Institute of Science and Technology Austria.","apa":"Arslan, F. N. (2022). <i>Remodeling of E-cadherin-mediated contacts via cortical  flows</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:12153\">https://doi.org/10.15479/at:ista:12153</a>"},"supervisor":[{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"ec_funded":1,"degree_awarded":"PhD","abstract":[{"lang":"eng","text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. The \r\nbinding of adhesion receptors and remodeling of the actomyosin cell cortex at cell-cell \r\ninteraction sites have been implicated in cell-cell contact formation. Yet, how these two \r\nprocesses functionally interact to drive cell-cell contact expansion and strengthening \r\nremains unclear. Here, we study how primary germ layer progenitor cells from zebrafish \r\nbind to supported lipid bilayers (SLB) functionalized with E-cadherin ectodomains as an \r\nassay system for monitoring cell-cell contact formation at high spatiotemporal resolution. \r\nWe show that cell-cell contact formation represents a two-tiered process: E-cadherin\u0002mediated downregulation of the small GTPase RhoA at the forming contact leads to both \r\ndepletion of Myosin-2 and decrease of F-actin. This is followed by centrifugal actin \r\nnetwork flows at the contact triggered by a sharp gradient of Myosin-2 at the rim of the \r\ncontact zone, with Myosin-2 displaying higher cortical localization outside than inside of \r\nthe contact. These centrifugal cortical actin flows, in turn, not only further dilute the actin \r\nnetwork at the contact disc, but also lead to an accumulation of both F-actin and E\u0002cadherin at the contact rim. Eventually, this combination of actomyosin downregulation \r\nand flows at the contact contribute to the characteristic molecular organization implicated \r\nin contact formation and maintenance: depletion of cortical actomyosin at the contact disc, \r\ndriving contact expansion by lowering interfacial tension at the contact, and accumulation \r\nof both E-cadherin and F-actin at the contact rim, mechanically linking the contractile \r\ncortices of the adhering cells. Thus, using a biomimetic assay, we exemplify how \r\nadhesion signaling and cell mechanics function together to modulate the spatial \r\norganization of cell-cell contacts."}],"status":"public","department":[{"_id":"GradSch"},{"_id":"CaHe"}],"alternative_title":["ISTA Thesis"],"month":"09","_id":"12368","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","title":"Remodeling of E-cadherin-mediated contacts via cortical  flows","related_material":{"record":[{"id":"9350","relation":"part_of_dissertation","status":"public"}]},"oa":1},{"article_processing_charge":"No","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_identifier":{"issn":["2663-337X"]},"page":"142","year":"2022","date_created":"2023-01-25T14:27:43Z","date_updated":"2023-08-04T09:40:37Z","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"ScienComp"}],"project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program","call_identifier":"H2020"}],"file":[{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","embargo_to":"open_access","file_id":"12379","date_created":"2023-01-25T14:31:32Z","access_level":"closed","date_updated":"2023-04-12T22:30:03Z","file_name":"Gloria_Colombo_Thesis.docx","file_size":23890382,"creator":"cchlebak","relation":"source_file","checksum":"8cd3ddfe9b53381dcf086023d8d8893a"},{"file_id":"12380","content_type":"application/pdf","date_created":"2023-01-25T14:31:36Z","date_updated":"2023-04-12T22:30:03Z","access_level":"open_access","file_name":"Gloria_Colombo_Thesis.pdf","embargo":"2023-04-11","file_size":13802421,"creator":"cchlebak","relation":"main_file","checksum":"8af4319c18b516e8758e9a6cb02b103b"}],"oa_version":"Published Version","date_published":"2022-11-11T00:00:00Z","ddc":["570"],"author":[{"id":"3483CF6C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9434-8902","last_name":"Colombo","full_name":"Colombo, Gloria","first_name":"Gloria"}],"doi":"10.15479/at:ista:12378","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"file_date_updated":"2023-04-12T22:30:03Z","type":"dissertation","day":"11","has_accepted_license":"1","supervisor":[{"orcid":"0000-0001-8635-0877","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","full_name":"Siegert, Sandra","first_name":"Sandra","last_name":"Siegert"}],"citation":{"ieee":"G. Colombo, “MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes,” Institute of Science and Technology Austria, 2022.","mla":"Colombo, Gloria. <i>MorphOMICs, a Tool for Mapping Microglial Morphology, Reveals Brain Region- and Sex-Dependent Phenotypes</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:12378\">10.15479/at:ista:12378</a>.","apa":"Colombo, G. (2022). <i>MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:12378\">https://doi.org/10.15479/at:ista:12378</a>","chicago":"Colombo, Gloria. “MorphOMICs, a Tool for Mapping Microglial Morphology, Reveals Brain Region- and Sex-Dependent Phenotypes.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:12378\">https://doi.org/10.15479/at:ista:12378</a>.","ista":"Colombo G. 2022. MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes. Institute of Science and Technology Austria.","ama":"Colombo G. MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:12378\">10.15479/at:ista:12378</a>","short":"G. Colombo, MorphOMICs, a Tool for Mapping Microglial Morphology, Reveals Brain Region- and Sex-Dependent Phenotypes, Institute of Science and Technology Austria, 2022."},"degree_awarded":"PhD","ec_funded":1,"status":"public","abstract":[{"text":"Environmental cues influence the highly dynamic morphology of microglia. Strategies to \r\ncharacterize these changes usually involve user-selected morphometric features, which \r\npreclude the identification of a spectrum of context-dependent morphological phenotypes. \r\nHere, we develop MorphOMICs, a topological data analysis approach, which enables semi\u0002automatic mapping of microglial morphology into an atlas of cue-dependent phenotypes,\r\novercomes feature-selection bias and minimizes biological variability. \r\nFirst, with MorphOMICs we derive the morphological spectrum of microglia across seven \r\nbrain regions during postnatal development and in two distinct Alzheimer’s disease \r\ndegeneration mouse models. We uncover region-specific and sexually dimorphic\r\nmorphological trajectories, with females showing an earlier morphological shift than males in \r\nthe degenerating brain. Overall, we demonstrate that both long primary- and short terminal \r\nprocesses provide distinct insights to morphological phenotypes. Moreover, using machine \r\nlearning to map novel condition on the spectrum, we observe that microglia morphologies \r\nreflect a dose-dependent adaptation upon ketamine anesthesia and do not recover to control \r\nmorphologies.\r\nNext, we took advantage of MorphOMICs to build a high-resolution and layer-specific map of \r\nmicroglial morphological spectrum in the retina, covering postnatal development and rd10 \r\ndegeneration. Here, following photoreceptor death, microglia assume an early development\u0002like morphology. Finally, we map microglial morphology following optic nerve crush on the \r\nretinal spectrum and observe a layer- and sex-dependent response. \r\nOverall, MorphOMICs opens a new perspective to analyze microglial morphology across \r\nmultiple conditions, and provides a novel tool to characterize microglial morphology beyond \r\nthe traditionally dichotomized view of microglia.","lang":"eng"}],"department":[{"_id":"GradSch"},{"_id":"SaSi"}],"alternative_title":["ISTA Thesis"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"11","_id":"12378","oa":1,"related_material":{"record":[{"id":"12244","relation":"part_of_dissertation","status":"public"}]},"title":"MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes","publication_status":"published"},{"oa_version":"Published Version","date_published":"2022-12-15T00:00:00Z","ddc":["500"],"author":[{"id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425","orcid":"0000-0002-6249-0928","last_name":"Brooks","first_name":"Morris","full_name":"Brooks, Morris"}],"doi":"10.15479/at:ista:12390","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"file_date_updated":"2023-01-26T10:02:42Z","type":"dissertation","article_processing_charge":"No","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"publication_identifier":{"issn":["2663-337X"]},"page":"196","year":"2022","date_created":"2023-01-26T10:00:42Z","date_updated":"2023-08-07T13:32:09Z","project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","grant_number":"694227","call_identifier":"H2020"}],"file":[{"access_level":"open_access","date_updated":"2023-01-26T10:02:34Z","success":1,"content_type":"application/pdf","date_created":"2023-01-26T10:02:34Z","file_id":"12391","file_name":"Brooks_Thesis.pdf","creator":"cchlebak","file_size":3095225,"checksum":"b31460e937f33b557abb40ebef02b567","relation":"main_file"},{"creator":"cchlebak","file_size":809842,"checksum":"9751869fa5e7981588ad4228f4fd4bd6","relation":"source_file","date_updated":"2023-01-26T10:02:42Z","access_level":"closed","content_type":"application/octet-stream","file_id":"12392","date_created":"2023-01-26T10:02:42Z","file_name":"Brooks_Thesis.tex"}],"department":[{"_id":"GradSch"},{"_id":"RoSe"}],"alternative_title":["ISTA Thesis"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"12390","month":"12","title":"Translation-invariant quantum systems with effectively broken symmetry","related_material":{"record":[{"id":"9005","relation":"part_of_dissertation","status":"public"}]},"oa":1,"publication_status":"published","day":"15","has_accepted_license":"1","supervisor":[{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Seiringer, Robert","last_name":"Seiringer"}],"citation":{"ista":"Brooks M. 2022. Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria.","apa":"Brooks, M. (2022). <i>Translation-invariant quantum systems with effectively broken symmetry</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:12390\">https://doi.org/10.15479/at:ista:12390</a>","chicago":"Brooks, Morris. “Translation-Invariant Quantum Systems with Effectively Broken Symmetry.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:12390\">https://doi.org/10.15479/at:ista:12390</a>.","mla":"Brooks, Morris. <i>Translation-Invariant Quantum Systems with Effectively Broken Symmetry</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:12390\">10.15479/at:ista:12390</a>.","ieee":"M. Brooks, “Translation-invariant quantum systems with effectively broken symmetry,” Institute of Science and Technology Austria, 2022.","short":"M. Brooks, Translation-Invariant Quantum Systems with Effectively Broken Symmetry, Institute of Science and Technology Austria, 2022.","ama":"Brooks M. Translation-invariant quantum systems with effectively broken symmetry. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:12390\">10.15479/at:ista:12390</a>"},"degree_awarded":"PhD","ec_funded":1,"status":"public","abstract":[{"lang":"eng","text":"The scope of this thesis is to study quantum systems exhibiting a continuous symmetry that\r\nis broken on the level of the corresponding effective theory. In particular we are going to\r\ninvestigate translation-invariant Bose gases in the mean field limit, effectively described by\r\nthe Hartree functional, and the Fröhlich Polaron in the regime of strong coupling, effectively\r\ndescribed by the Pekar functional. The latter is a model describing the interaction between a\r\ncharged particle and the optical modes of a polar crystal. Regarding the former, we assume in\r\naddition that the particles in the gas are unconfined, and typically we will consider particles\r\nthat are subject to an attractive interaction. In both cases the ground state energy of the\r\nHamiltonian is not a proper eigenvalue due to the underlying translation-invariance, while on\r\nthe contrary there exists a whole invariant orbit of minimizers for the corresponding effective\r\nfunctionals. Both, the absence of proper eigenstates and the broken symmetry of the effective\r\ntheory, make the study significantly more involved and it is the content of this thesis to\r\ndevelop a frameworks which allows for a systematic way to circumvent these issues.\r\nIt is a well-established result that the ground state energy of Bose gases in the mean field limit,\r\nas well as the ground state energy of the Fröhlich Polaron in the regime of strong coupling, is\r\nto leading order given by the minimal energy of the corresponding effective theory. As part\r\nof this thesis we identify the sub-leading term in the expansion of the ground state energy,\r\nwhich can be interpreted as the quantum correction to the classical energy, since the effective\r\ntheories under consideration can be seen as classical counterparts.\r\nWe are further going to establish an asymptotic expression for the energy-momentum relation\r\nof the Fröhlich Polaron in the strong coupling limit. In the regime of suitably small momenta,\r\nthis asymptotic expression agrees with the energy-momentum relation of a free particle having\r\nan effectively increased mass, and we find that this effectively increased mass agrees with the\r\nconjectured value in the physics literature.\r\nIn addition we will discuss two unrelated papers written by the author during his stay at ISTA\r\nin the appendix. The first one concerns the realization of anyons, which are quasi-particles\r\nacquiring a non-trivial phase under the exchange of two particles, as molecular impurities.\r\nThe second one provides a classification of those vector fields defined on a given manifold\r\nthat can be written as the gradient of a given functional with respect to a suitable metric,\r\nprovided that some mild smoothness assumptions hold. This classification is subsequently\r\nused to identify those quantum Markov semigroups that can be written as a gradient flow of\r\nthe relative entropy.\r\n"}]},{"article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"date_updated":"2024-09-10T12:04:26Z","year":"2022","date_created":"2023-01-26T11:55:16Z","page":"105","file":[{"checksum":"cc4a2b4a7e3c4ee8ef7f2dbf909b12bd","relation":"main_file","creator":"cchlebak","file_size":42059787,"embargo":"2023-12-20","file_name":"PhD-Thesis_Saren Tasciyan_formatted_aftercrash_fixed_600dpi_95pc_final_PDFA3b.pdf","date_updated":"2023-12-21T23:30:03Z","access_level":"open_access","content_type":"application/pdf","date_created":"2023-01-26T11:58:14Z","file_id":"12402"},{"file_size":261256696,"creator":"cchlebak","relation":"source_file","checksum":"f1b4ca98b8ab0cb043b1830971e9bd9c","embargo_to":"open_access","content_type":"application/x-zip-compressed","file_id":"12403","date_created":"2023-01-26T12:00:10Z","date_updated":"2023-12-21T23:30:03Z","access_level":"closed","file_name":"Source Files - Saren Tasciyan - PhD Thesis.zip"}],"date_published":"2022-12-22T00:00:00Z","oa_version":"Published Version","author":[{"full_name":"Tasciyan, Saren","first_name":"Saren","last_name":"Tasciyan","orcid":"0000-0003-1671-393X","id":"4323B49C-F248-11E8-B48F-1D18A9856A87"}],"ddc":["610"],"publisher":"Institute of Science and Technology Austria","doi":"10.15479/at:ista:12401","type":"dissertation","file_date_updated":"2023-12-21T23:30:03Z","language":[{"iso":"eng"}],"has_accepted_license":"1","day":"22","citation":{"ista":"Tasciyan S. 2022. Role of microenvironment heterogeneity in cancer cell invasion. Institute of Science and Technology Austria.","apa":"Tasciyan, S. (2022). <i>Role of microenvironment heterogeneity in cancer cell invasion</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:12401\">https://doi.org/10.15479/at:ista:12401</a>","chicago":"Tasciyan, Saren. “Role of Microenvironment Heterogeneity in Cancer Cell Invasion.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:12401\">https://doi.org/10.15479/at:ista:12401</a>.","mla":"Tasciyan, Saren. <i>Role of Microenvironment Heterogeneity in Cancer Cell Invasion</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:12401\">10.15479/at:ista:12401</a>.","ieee":"S. Tasciyan, “Role of microenvironment heterogeneity in cancer cell invasion,” Institute of Science and Technology Austria, 2022.","short":"S. Tasciyan, Role of Microenvironment Heterogeneity in Cancer Cell Invasion, Institute of Science and Technology Austria, 2022.","ama":"Tasciyan S. Role of microenvironment heterogeneity in cancer cell invasion. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:12401\">10.15479/at:ista:12401</a>"},"supervisor":[{"full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"degree_awarded":"PhD","abstract":[{"text":"Detachment of the cancer cells from the bulk of the tumor is the first step of metastasis, which\r\nis the primary cause of cancer related deaths. It is unclear, which factors contribute to this step.\r\nRecent studies indicate a crucial role of the tumor microenvironment in malignant\r\ntransformation and metastasis. Studying cancer cell invasion and detachments quantitatively in\r\nthe context of its physiological microenvironment is technically challenging. Especially, precise\r\ncontrol of microenvironmental properties in vivo is currently not possible. Here, I studied the\r\nrole of microenvironment geometry in the invasion and detachment of cancer cells from the\r\nbulk with a simplistic and reductionist approach. In this approach, I engineered microfluidic\r\ndevices to mimic a pseudo 3D extracellular matrix environment, where I was able to\r\nquantitatively tune the geometrical configuration of the microenvironment and follow tumor\r\ncells with fluorescence live imaging. To aid quantitative analysis I developed a widely applicable\r\nsoftware application to automatically analyze and visualize particle tracking data.\r\nQuantitative analysis of tumor cell invasion in isotropic and anisotropic microenvironments\r\nshowed that heterogeneity in the microenvironment promotes faster invasion and more\r\nfrequent detachment of cells. These observations correlated with overall higher speed of cells at\r\nthe edge of the bulk of the cells. In heterogeneous microenvironments cells preferentially\r\npassed through larger pores, thus invading areas of least resistance and generating finger-like\r\ninvasive structures. The detachments occurred mostly at the tips of these structures.\r\nTo investigate the potential mechanism, we established a two dimensional model to simulate\r\nactive Brownian particles representing the cell nuclei dynamics. These simulations backed our in\r\nvitro observations without the need of precise fitting the simulation parameters. Our model\r\nsuggests the importance of the pore heterogeneity in the direction perpendicular to the\r\norientation of bias field (lateral heterogeneity), which causes the interface roughening.","lang":"eng"}],"status":"public","department":[{"_id":"GradSch"},{"_id":"MiSi"}],"alternative_title":["ISTA Thesis"],"month":"12","_id":"12401","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_status":"published","related_material":{"record":[{"id":"679","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"10703"},{"relation":"part_of_dissertation","status":"public","id":"7885"},{"id":"9429","relation":"part_of_dissertation","status":"public"}]},"title":"Role of microenvironment heterogeneity in cancer cell invasion","oa":1},{"acknowledgement":"This research was partially supported by the ERC CoG 863818 (ForM-SMArt) grant.","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"date_published":"2022-09-28T00:00:00Z","oa_version":"Preprint","external_id":{"arxiv":["2209.14368"]},"author":[{"full_name":"Chatterjee, Krishnendu","first_name":"Krishnendu","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X"},{"last_name":"Mohammadi","full_name":"Mohammadi, Mona","first_name":"Mona","id":"4363614d-b686-11ed-a7d5-ac9e4a24bc2e"},{"orcid":"0000-0001-5103-038X","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","first_name":"Raimundo J","full_name":"Saona Urmeneta, Raimundo J","last_name":"Saona Urmeneta"}],"publication":"arXiv","month":"09","_id":"12677","doi":"10.48550/ARXIV.2209.14368","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"preprint","language":[{"iso":"eng"}],"arxiv":1,"publication_status":"submitted","title":"Repeated prophet inequality with near-optimal bounds","oa":1,"article_processing_charge":"No","day":"28","citation":{"ieee":"K. Chatterjee, M. Mohammadi, and R. J. Saona Urmeneta, “Repeated prophet inequality with near-optimal bounds,” <i>arXiv</i>. .","mla":"Chatterjee, Krishnendu, et al. “Repeated Prophet Inequality with Near-Optimal Bounds.” <i>ArXiv</i>, 2209.14368, doi:<a href=\"https://doi.org/10.48550/ARXIV.2209.14368\">10.48550/ARXIV.2209.14368</a>.","chicago":"Chatterjee, Krishnendu, Mona Mohammadi, and Raimundo J Saona Urmeneta. “Repeated Prophet Inequality with Near-Optimal Bounds.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/ARXIV.2209.14368\">https://doi.org/10.48550/ARXIV.2209.14368</a>.","apa":"Chatterjee, K., Mohammadi, M., &#38; Saona Urmeneta, R. J. (n.d.). Repeated prophet inequality with near-optimal bounds. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/ARXIV.2209.14368\">https://doi.org/10.48550/ARXIV.2209.14368</a>","ista":"Chatterjee K, Mohammadi M, Saona Urmeneta RJ. Repeated prophet inequality with near-optimal bounds. arXiv, 2209.14368.","ama":"Chatterjee K, Mohammadi M, Saona Urmeneta RJ. Repeated prophet inequality with near-optimal bounds. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/ARXIV.2209.14368\">10.48550/ARXIV.2209.14368</a>","short":"K. Chatterjee, M. Mohammadi, R.J. Saona Urmeneta, ArXiv (n.d.)."},"main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2209.14368"}],"project":[{"grant_number":"863818","name":"Formal Methods for Stochastic Models: Algorithms and Applications","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"}],"date_updated":"2025-07-14T09:09:51Z","ec_funded":1,"date_created":"2023-02-24T12:21:40Z","year":"2022","abstract":[{"text":"In modern sample-driven Prophet Inequality, an adversary chooses a sequence of n items with values v1,v2,…,vn to be presented to a decision maker (DM). The process follows in two phases. In the first phase (sampling phase), some items, possibly selected at random, are revealed to the DM, but she can never accept them. In the second phase, the DM is presented with the other items in a random order and online fashion. For each item, she must make an irrevocable decision to either accept the item and stop the process or reject the item forever and proceed to the next item. The goal of the DM is to maximize the expected value as compared to a Prophet (or offline algorithm) that has access to all information. In this setting, the sampling phase has no cost and is not part of the optimization process. However, in many scenarios, the samples are obtained as part of the decision-making process.\r\nWe model this aspect as a two-phase Prophet Inequality where an adversary chooses a sequence of 2n items with values v1,v2,…,v2n and the items are randomly ordered. Finally, there are two phases of the Prophet Inequality problem with the first n-items and the rest of the items, respectively. We show that some basic algorithms achieve a ratio of at most 0.450. We present an algorithm that achieves a ratio of at least 0.495. Finally, we show that for every algorithm the ratio it can achieve is at most 0.502. Hence our algorithm is near-optimal.","lang":"eng"}],"status":"public","article_number":"2209.14368"},{"author":[{"last_name":"Brighi","first_name":"Pietro","full_name":"Brighi, Pietro","id":"4115AF5C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7969-2729"},{"orcid":"0000-0003-0038-7068","id":"F75EE9BE-5C90-11EA-905D-16643DDC885E","last_name":"Ljubotina","full_name":"Ljubotina, Marko","first_name":"Marko"},{"first_name":"Maksym","full_name":"Serbyn, Maksym","last_name":"Serbyn","orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"}],"publication":"arXiv","department":[{"_id":"GradSch"},{"_id":"MaSe"}],"date_published":"2022-11-07T00:00:00Z","external_id":{"arxiv":["2210.15607"]},"oa_version":"Preprint","type":"preprint","language":[{"iso":"eng"}],"arxiv":1,"publication_status":"submitted","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"12732"},{"status":"public","relation":"later_version","id":"14334"}]},"title":"Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models","oa":1,"month":"11","_id":"12750","doi":"10.48550/arXiv.2210.15607","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Brighi P, Ljubotina M, Serbyn M. Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2210.15607\">10.48550/arXiv.2210.15607</a>","short":"P. Brighi, M. Ljubotina, M. Serbyn, ArXiv (n.d.).","mla":"Brighi, Pietro, et al. “Hilbert Space Fragmentation and Slow Dynamics in Particle-Conserving Quantum East Models.” <i>ArXiv</i>, 2210.15607, doi:<a href=\"https://doi.org/10.48550/arXiv.2210.15607\">10.48550/arXiv.2210.15607</a>.","ieee":"P. Brighi, M. Ljubotina, and M. Serbyn, “Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models,” <i>arXiv</i>. .","ista":"Brighi P, Ljubotina M, Serbyn M. Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models. arXiv, 2210.15607.","apa":"Brighi, P., Ljubotina, M., &#38; Serbyn, M. (n.d.). Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2210.15607\">https://doi.org/10.48550/arXiv.2210.15607</a>","chicago":"Brighi, Pietro, Marko Ljubotina, and Maksym Serbyn. “Hilbert Space Fragmentation and Slow Dynamics in Particle-Conserving Quantum East Models.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2210.15607\">https://doi.org/10.48550/arXiv.2210.15607</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2210.15607"}],"article_processing_charge":"No","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"day":"07","abstract":[{"text":"Quantum kinetically constrained models have recently attracted significant attention due to their anomalous dynamics and thermalization. In this work, we introduce a hitherto unexplored family of kinetically constrained models featuring a conserved particle number and strong inversion-symmetry breaking due to facilitated hopping. We demonstrate that these models provide a generic example of so-called quantum Hilbert space fragmentation, that is manifested in disconnected sectors in the Hilbert space that are not apparent in the computational basis. Quantum Hilbert space fragmentation leads to an exponential in system size number of eigenstates with exactly zero entanglement entropy across several bipartite cuts. These eigenstates can be probed dynamically using quenches from simple initial product states. In addition, we study the particle spreading under unitary dynamics launched from the domain wall state, and find faster than diffusive dynamics at high particle densities, that crosses over into logarithmically slow relaxation at smaller densities. Using a classically simulable cellular automaton, we reproduce the logarithmic dynamics observed in the quantum case. Our work suggests that particle conserving constrained models with inversion symmetry breaking realize so far unexplored universality classes of dynamics and invite their further theoretical and experimental studies.","lang":"eng"}],"status":"public","article_number":"2210.15607","date_updated":"2023-09-20T10:46:29Z","date_created":"2023-03-23T14:33:13Z","year":"2022"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2203.16701"}],"citation":{"ista":"Bombari S, Achille A, Wang Z, Wang Y-X, Xie Y, Singh KY, Appalaraju S, Mahadevan V, Soatto S. Towards differential relational privacy and its use in question answering. arXiv, 2203.16701.","apa":"Bombari, S., Achille, A., Wang, Z., Wang, Y.-X., Xie, Y., Singh, K. Y., … Soatto, S. (n.d.). Towards differential relational privacy and its use in question answering. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2203.16701\">https://doi.org/10.48550/arXiv.2203.16701</a>","chicago":"Bombari, Simone, Alessandro Achille, Zijian Wang, Yu-Xiang Wang, Yusheng Xie, Kunwar Yashraj Singh, Srikar Appalaraju, Vijay Mahadevan, and Stefano Soatto. “Towards Differential Relational Privacy and Its Use in Question Answering.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2203.16701\">https://doi.org/10.48550/arXiv.2203.16701</a>.","mla":"Bombari, Simone, et al. “Towards Differential Relational Privacy and Its Use in Question Answering.” <i>ArXiv</i>, 2203.16701, doi:<a href=\"https://doi.org/10.48550/arXiv.2203.16701\">10.48550/arXiv.2203.16701</a>.","ieee":"S. Bombari <i>et al.</i>, “Towards differential relational privacy and its use in question answering,” <i>arXiv</i>. .","short":"S. Bombari, A. Achille, Z. Wang, Y.-X. Wang, Y. Xie, K.Y. Singh, S. Appalaraju, V. Mahadevan, S. Soatto, ArXiv (n.d.).","ama":"Bombari S, Achille A, Wang Z, et al. Towards differential relational privacy and its use in question answering. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2203.16701\">10.48550/arXiv.2203.16701</a>"},"day":"30","article_processing_charge":"No","article_number":"2203.16701","status":"public","abstract":[{"lang":"eng","text":"Memorization of the relation between entities in a dataset can lead to privacy issues when using a trained model for question answering. We introduce Relational Memorization (RM) to understand, quantify and control this phenomenon. While bounding general memorization can have detrimental effects on the performance of a trained model, bounding RM does not prevent effective learning. The difference is most pronounced when the data distribution is long-tailed, with many queries having only few training examples: Impeding general memorization prevents effective learning, while impeding only relational memorization still allows learning general properties of the underlying concepts. We formalize the notion of Relational Privacy (RP) and, inspired by Differential Privacy (DP), we provide a possible definition of Differential Relational Privacy (DrP). These notions can be used to describe and compute bounds on the amount of RM in a trained model. We illustrate Relational Privacy concepts in experiments with large-scale models for Question Answering."}],"year":"2022","date_created":"2023-04-23T16:11:48Z","date_updated":"2023-04-25T07:34:49Z","publication":"arXiv","author":[{"id":"ca726dda-de17-11ea-bc14-f9da834f63aa","full_name":"Bombari, Simone","first_name":"Simone","last_name":"Bombari"},{"full_name":"Achille, Alessandro","first_name":"Alessandro","last_name":"Achille"},{"first_name":"Zijian","full_name":"Wang, Zijian","last_name":"Wang"},{"first_name":"Yu-Xiang","full_name":"Wang, Yu-Xiang","last_name":"Wang"},{"first_name":"Yusheng","full_name":"Xie, Yusheng","last_name":"Xie"},{"full_name":"Singh, Kunwar Yashraj","first_name":"Kunwar Yashraj","last_name":"Singh"},{"last_name":"Appalaraju","first_name":"Srikar","full_name":"Appalaraju, Srikar"},{"last_name":"Mahadevan","first_name":"Vijay","full_name":"Mahadevan, Vijay"},{"last_name":"Soatto","first_name":"Stefano","full_name":"Soatto, Stefano"}],"oa_version":"Preprint","external_id":{"arxiv":["2203.16701"]},"date_published":"2022-03-30T00:00:00Z","department":[{"_id":"GradSch"},{"_id":"MaMo"}],"oa":1,"title":"Towards differential relational privacy and its use in question answering","arxiv":1,"publication_status":"submitted","language":[{"iso":"eng"}],"type":"preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"03","_id":"12860","doi":"10.48550/arXiv.2203.16701"},{"volume":47,"isi":1,"quality_controlled":"1","page":"100-119","date_created":"2021-04-08T09:33:31Z","year":"2022","date_updated":"2023-09-05T13:16:11Z","project":[{"call_identifier":"FWF","grant_number":"S11407","name":"Game Theory","_id":"25863FF4-B435-11E9-9278-68D0E5697425"}],"publication_identifier":{"issn":["0364-765X"],"eissn":["1526-5471"]},"scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1904.13360"}],"article_processing_charge":"No","arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","doi":"10.1287/moor.2020.1116","publisher":"Institute for Operations Research and the Management Sciences","issue":"1","publication":"Mathematics of Operations Research","author":[{"last_name":"Chatterjee","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X"},{"last_name":"Saona Urmeneta","full_name":"Saona Urmeneta, Raimundo J","first_name":"Raimundo J","orcid":"0000-0001-5103-038X","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425"},{"last_name":"Ziliotto","full_name":"Ziliotto, Bruno","first_name":"Bruno"}],"oa_version":"Preprint","external_id":{"isi":["000731918100001"],"arxiv":["1904.13360"]},"date_published":"2022-02-01T00:00:00Z","status":"public","abstract":[{"lang":"eng","text":"Partially observable Markov decision processes (POMDPs) are standard models for dynamic systems with probabilistic and nondeterministic behaviour in uncertain environments. We prove that in POMDPs with long-run average objective, the decision maker has approximately optimal strategies with finite memory. This implies notably that approximating the long-run value is recursively enumerable, as well as a weak continuity property of the value with respect to the transition function. "}],"keyword":["Management Science and Operations Research","General Mathematics","Computer Science Applications"],"intvolume":"        47","citation":{"short":"K. Chatterjee, R.J. Saona Urmeneta, B. Ziliotto, Mathematics of Operations Research 47 (2022) 100–119.","ama":"Chatterjee K, Saona Urmeneta RJ, Ziliotto B. Finite-memory strategies in POMDPs with long-run average objectives. <i>Mathematics of Operations Research</i>. 2022;47(1):100-119. doi:<a href=\"https://doi.org/10.1287/moor.2020.1116\">10.1287/moor.2020.1116</a>","ista":"Chatterjee K, Saona Urmeneta RJ, Ziliotto B. 2022. Finite-memory strategies in POMDPs with long-run average objectives. Mathematics of Operations Research. 47(1), 100–119.","chicago":"Chatterjee, Krishnendu, Raimundo J Saona Urmeneta, and Bruno Ziliotto. “Finite-Memory Strategies in POMDPs with Long-Run Average Objectives.” <i>Mathematics of Operations Research</i>. Institute for Operations Research and the Management Sciences, 2022. <a href=\"https://doi.org/10.1287/moor.2020.1116\">https://doi.org/10.1287/moor.2020.1116</a>.","apa":"Chatterjee, K., Saona Urmeneta, R. J., &#38; Ziliotto, B. (2022). Finite-memory strategies in POMDPs with long-run average objectives. <i>Mathematics of Operations Research</i>. Institute for Operations Research and the Management Sciences. <a href=\"https://doi.org/10.1287/moor.2020.1116\">https://doi.org/10.1287/moor.2020.1116</a>","mla":"Chatterjee, Krishnendu, et al. “Finite-Memory Strategies in POMDPs with Long-Run Average Objectives.” <i>Mathematics of Operations Research</i>, vol. 47, no. 1, Institute for Operations Research and the Management Sciences, 2022, pp. 100–19, doi:<a href=\"https://doi.org/10.1287/moor.2020.1116\">10.1287/moor.2020.1116</a>.","ieee":"K. Chatterjee, R. J. Saona Urmeneta, and B. Ziliotto, “Finite-memory strategies in POMDPs with long-run average objectives,” <i>Mathematics of Operations Research</i>, vol. 47, no. 1. Institute for Operations Research and the Management Sciences, pp. 100–119, 2022."},"day":"01","oa":1,"title":"Finite-memory strategies in POMDPs with long-run average objectives","publication_status":"published","article_type":"original","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"02","_id":"9311","acknowledgement":"Partially supported by Austrian Science Fund (FWF) NFN Grant No RiSE/SHiNE S11407, by CONICYT Chile through grant PII 20150140, and by ECOS-CONICYT through grant C15E03.\r\n","department":[{"_id":"GradSch"},{"_id":"KrCh"}]},{"status":"public","abstract":[{"lang":"eng","text":"Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the candidate variant on both MED11 RNA and protein was assessed using reverse transcriptase polymerase chain reaction and western blotting using fibroblast cell lines derived from 1 affected individual and controls and through computational approaches. Knockouts in zebrafish were generated using clustered regularly interspaced short palindromic repeats/Cas9. Results: The disease was characterized by microcephaly, profound neurodevelopmental impairment, exaggerated startle response, myoclonic seizures, progressive widespread neurodegeneration, and premature death. Functional studies on patient-derived fibroblasts did not show a loss of protein function but rather disruption of the C-terminal of MED11, likely impairing binding to other MED subunits. A zebrafish knockout model recapitulates key clinical phenotypes. Conclusion: Loss of the C-terminal of MED subunit 11 may affect its binding efficiency to other MED subunits, thus implicating the MED-complex stability in brain development and neurodegeneration. (C) 2022 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics."}],"extern":"1","keyword":["Human mediator complex","MED11","MEDopathies"],"citation":{"ieee":"E. Cali <i>et al.</i>, “A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease,” <i>Genetics in Medicine</i>, vol. 24, no. 10. Elsevier, pp. 2194–2203, 2022.","mla":"Cali, Elisa, et al. “A Homozygous MED11 C-Terminal Variant Causes a Lethal Neurodegenerative Disease.” <i>Genetics in Medicine</i>, vol. 24, no. 10, Elsevier, 2022, pp. 2194–203, doi:<a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">10.1016/j.gim.2022.07.013</a>.","apa":"Cali, E., Lin, S.-J., Rocca, C., Sahin, Y., Al Shamsi, A., El Chehadeh, S., … Grp, Syn. S. (2022). A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. <i>Genetics in Medicine</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">https://doi.org/10.1016/j.gim.2022.07.013</a>","ista":"Cali E, Lin S-J, Rocca C, Sahin Y, Al Shamsi A, El Chehadeh S, Chaabouni M, Mankad K, Galanaki E, Efthymiou S, Sudhakar S, Athanasiou-Fragkouli A, Celik T, Narli N, Bianca S, Murphy D, Moreira FMDC, Accogli A, Petree C, Huang K, Monastiri K, Edizadeh M, Nardello R, Ognibene M, De Marco P, Ruggieri M, Zara F, Striano P, Sahin Y, Al-Gazali L, Warde MTA, Gerard B, Zifarelli G, Beetz C, Fortuna S, Soler M, Valente EM, Varshney G, Maroofian R, Salpietro V, Houlden H, Grp SynS. 2022. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. Genetics in Medicine. 24(10), 2194–2203.","chicago":"Cali, Elisa, Sheng-Jia Lin, Clarissa Rocca, Yavuz Sahin, Aisha Al Shamsi, Salima El Chehadeh, Myriam Chaabouni, et al. “A Homozygous MED11 C-Terminal Variant Causes a Lethal Neurodegenerative Disease.” <i>Genetics in Medicine</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">https://doi.org/10.1016/j.gim.2022.07.013</a>.","ama":"Cali E, Lin S-J, Rocca C, et al. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. <i>Genetics in Medicine</i>. 2022;24(10):2194-2203. doi:<a href=\"https://doi.org/10.1016/j.gim.2022.07.013\">10.1016/j.gim.2022.07.013</a>","short":"E. Cali, S.-J. Lin, C. Rocca, Y. Sahin, A. Al Shamsi, S. El Chehadeh, M. Chaabouni, K. Mankad, E. Galanaki, S. Efthymiou, S. Sudhakar, A. Athanasiou-Fragkouli, T. Celik, N. Narli, S. Bianca, D. Murphy, F.M.D.C. Moreira, A. Accogli, C. Petree, K. Huang, K. Monastiri, M. Edizadeh, R. Nardello, M. Ognibene, P. De Marco, M. Ruggieri, F. Zara, P. Striano, Y. Sahin, L. Al-Gazali, M.T.A. Warde, B. Gerard, G. Zifarelli, C. Beetz, S. Fortuna, M. Soler, E.M. Valente, G. Varshney, R. Maroofian, V. Salpietro, H. Houlden, Syn.S. Grp, Genetics in Medicine 24 (2022) 2194–2203."},"intvolume":"        24","day":"01","has_accepted_license":"1","oa":1,"title":"A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease","publication_status":"published","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"14355","month":"10","department":[{"_id":"GradSch"}],"volume":24,"file":[{"checksum":"8117175a89129eb5022d81ffe7625f9f","relation":"main_file","creator":"dernst","file_size":1434037,"file_name":"2022_GeneticsMedicine_Calin.pdf","date_updated":"2023-09-25T08:56:06Z","success":1,"access_level":"open_access","file_id":"14371","content_type":"application/pdf","date_created":"2023-09-25T08:56:06Z"}],"quality_controlled":"1","page":"2194-2203","year":"2022","date_created":"2023-09-20T20:57:18Z","date_updated":"2023-09-25T08:57:07Z","publication_identifier":{"issn":["1098-3600"]},"scopus_import":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"article_processing_charge":"No","language":[{"iso":"eng"}],"file_date_updated":"2023-09-25T08:56:06Z","type":"journal_article","doi":"10.1016/j.gim.2022.07.013","publisher":"Elsevier","issue":"10","publication":"Genetics in Medicine","ddc":["570"],"author":[{"last_name":"Cali","full_name":"Cali, Elisa","first_name":"Elisa"},{"last_name":"Lin","first_name":"Sheng-Jia","full_name":"Lin, Sheng-Jia"},{"first_name":"Clarissa","full_name":"Rocca, Clarissa","last_name":"Rocca"},{"last_name":"Sahin","full_name":"Sahin, Yavuz","first_name":"Yavuz"},{"first_name":"Aisha","full_name":"Al Shamsi, Aisha","last_name":"Al Shamsi"},{"last_name":"El Chehadeh","full_name":"El Chehadeh, Salima","first_name":"Salima"},{"last_name":"Chaabouni","full_name":"Chaabouni, Myriam","first_name":"Myriam"},{"full_name":"Mankad, Kshitij","first_name":"Kshitij","last_name":"Mankad"},{"full_name":"Galanaki, Evangelia","first_name":"Evangelia","last_name":"Galanaki"},{"first_name":"Stephanie","full_name":"Efthymiou, Stephanie","last_name":"Efthymiou"},{"last_name":"Sudhakar","full_name":"Sudhakar, Sniya","first_name":"Sniya"},{"last_name":"Athanasiou-Fragkouli","full_name":"Athanasiou-Fragkouli, Alkyoni","first_name":"Alkyoni"},{"last_name":"Celik","first_name":"Tamer","full_name":"Celik, Tamer"},{"full_name":"Narli, Nejat","first_name":"Nejat","last_name":"Narli"},{"last_name":"Bianca","first_name":"Sebastiano","full_name":"Bianca, Sebastiano"},{"full_name":"Murphy, David","first_name":"David","last_name":"Murphy"},{"full_name":"Moreira, Francisco Martins De Carvalho","first_name":"Francisco Martins De Carvalho","last_name":"Moreira"},{"last_name":"Accogli","full_name":"Accogli, Andrea","first_name":"Andrea"},{"last_name":"Petree","first_name":"Cassidy","full_name":"Petree, Cassidy"},{"id":"3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3","orcid":"0000-0002-2512-7812","last_name":"Huang","first_name":"Kevin","full_name":"Huang, Kevin"},{"last_name":"Monastiri","first_name":"Kamel","full_name":"Monastiri, Kamel"},{"first_name":"Masoud","full_name":"Edizadeh, Masoud","last_name":"Edizadeh"},{"first_name":"Rosaria","full_name":"Nardello, Rosaria","last_name":"Nardello"},{"full_name":"Ognibene, Marzia","first_name":"Marzia","last_name":"Ognibene"},{"full_name":"De Marco, Patrizia","first_name":"Patrizia","last_name":"De Marco"},{"first_name":"Martino","full_name":"Ruggieri, Martino","last_name":"Ruggieri"},{"last_name":"Zara","full_name":"Zara, Federico","first_name":"Federico"},{"full_name":"Striano, Pasquale","first_name":"Pasquale","last_name":"Striano"},{"full_name":"Sahin, Yavuz","first_name":"Yavuz","last_name":"Sahin"},{"first_name":"Lihadh","full_name":"Al-Gazali, Lihadh","last_name":"Al-Gazali"},{"last_name":"Warde","first_name":"Marie Therese Abi","full_name":"Warde, Marie Therese Abi"},{"full_name":"Gerard, Benedicte","first_name":"Benedicte","last_name":"Gerard"},{"last_name":"Zifarelli","full_name":"Zifarelli, Giovanni","first_name":"Giovanni"},{"full_name":"Beetz, Christian","first_name":"Christian","last_name":"Beetz"},{"full_name":"Fortuna, Sara","first_name":"Sara","last_name":"Fortuna"},{"last_name":"Soler","full_name":"Soler, Miguel","first_name":"Miguel"},{"last_name":"Valente","first_name":"Enza Maria","full_name":"Valente, Enza Maria"},{"first_name":"Gaurav","full_name":"Varshney, Gaurav","last_name":"Varshney"},{"full_name":"Maroofian, Reza","first_name":"Reza","last_name":"Maroofian"},{"first_name":"Vincenzo","full_name":"Salpietro, Vincenzo","last_name":"Salpietro"},{"full_name":"Houlden, Henry","first_name":"Henry","last_name":"Houlden"},{"last_name":"Grp","full_name":"Grp, SYNaPS Study","first_name":"SYNaPS Study"}],"oa_version":"Published Version","date_published":"2022-10-01T00:00:00Z"},{"year":"2022","date_created":"2022-01-03T12:19:48Z","quality_controlled":"1","project":[{"call_identifier":"H2020","grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"date_updated":"2023-08-02T13:44:32Z","isi":1,"volume":63,"article_processing_charge":"No","publication_identifier":{"eissn":["1089-7658"],"issn":["0022-2488"]},"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2012.15238","open_access":"1"}],"doi":"10.1063/5.0051632","publisher":"AIP Publishing","language":[{"iso":"eng"}],"arxiv":1,"type":"journal_article","oa_version":"Preprint","external_id":{"arxiv":["2012.15238"],"isi":["000739446000009"]},"date_published":"2022-01-03T00:00:00Z","issue":"1","publication":"Journal of Mathematical Physics","author":[{"last_name":"Henheik","first_name":"Sven Joscha","full_name":"Henheik, Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","orcid":"0000-0003-1106-327X"},{"full_name":"Teufel, Stefan","first_name":"Stefan","last_name":"Teufel"}],"ec_funded":1,"status":"public","article_number":"011901","abstract":[{"text":"We show that recent results on adiabatic theory for interacting gapped many-body systems on finite lattices remain valid in the thermodynamic limit. More precisely, we prove a generalized super-adiabatic theorem for the automorphism group describing the infinite volume dynamics on the quasi-local algebra of observables. The key assumption is the existence of a sequence of gapped finite volume Hamiltonians, which generates the same infinite volume dynamics in the thermodynamic limit. Our adiabatic theorem also holds for certain perturbations of gapped ground states that close the spectral gap (so it is also an adiabatic theorem for resonances and, in this sense, “generalized”), and it provides an adiabatic approximation to all orders in the adiabatic parameter (a property often called “super-adiabatic”). In addition to the existing results for finite lattices, we also perform a resummation of the adiabatic expansion and allow for observables that are not strictly local. Finally, as an application, we prove the validity of linear and higher order response theory for our class of perturbations for infinite systems. While we consider the result and its proof as new and interesting in itself, we also lay the foundation for the proof of an adiabatic theorem for systems with a gap only in the bulk, which will be presented in a follow-up article.","lang":"eng"}],"day":"03","keyword":["mathematical physics","statistical and nonlinear physics"],"citation":{"ieee":"S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap,” <i>Journal of Mathematical Physics</i>, vol. 63, no. 1. AIP Publishing, 2022.","mla":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Uniform Gap.” <i>Journal of Mathematical Physics</i>, vol. 63, no. 1, 011901, AIP Publishing, 2022, doi:<a href=\"https://doi.org/10.1063/5.0051632\">10.1063/5.0051632</a>.","apa":"Henheik, S. J., &#38; Teufel, S. (2022). Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. <i>Journal of Mathematical Physics</i>. 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Teufel, Journal of Mathematical Physics 63 (2022)."},"intvolume":"        63","month":"01","_id":"10600","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","oa":1,"title":"Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap","article_type":"original","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"acknowledgement":"J.H. acknowledges partial financial support from ERC Advanced Grant “RMTBeyond” No. 101020331."},{"doi":"10.1007/s11040-021-09415-0","publisher":"Springer Nature","arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","file_date_updated":"2022-01-14T07:27:45Z","external_id":{"isi":["000741387600001"],"arxiv":["2106.02015"]},"oa_version":"Published Version","date_published":"2022-01-11T00:00:00Z","issue":"1","publication":"Mathematical Physics, Analysis and Geometry","author":[{"first_name":"Sven Joscha","full_name":"Henheik, Sven Joscha","last_name":"Henheik","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","orcid":"0000-0003-1106-327X"}],"ddc":["514"],"year":"2022","date_created":"2022-01-13T15:40:53Z","quality_controlled":"1","project":[{"call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta","grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"date_updated":"2023-08-02T13:51:52Z","file":[{"checksum":"d44f8123a52592a75b2c3b8ee2cd2435","relation":"main_file","creator":"cchlebak","file_size":505804,"file_name":"2022_MathPhyAnalGeo_Henheik.pdf","date_updated":"2022-01-14T07:27:45Z","success":1,"access_level":"open_access","date_created":"2022-01-14T07:27:45Z","file_id":"10624","content_type":"application/pdf"}],"isi":1,"volume":25,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"article_processing_charge":"Yes (via OA deal)","publication_identifier":{"eissn":["1572-9656"],"issn":["1385-0172"]},"scopus_import":"1","month":"01","_id":"10623","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","title":"The BCS critical temperature at high density","oa":1,"article_type":"original","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"acknowledgement":"I am very grateful to Robert Seiringer for his guidance during this project and for many valuable comments on an earlier version of the manuscript. Moreover, I would like to thank Asbjørn Bækgaard Lauritsen for many helpful discussions and comments, pointing out the reference [22] and for his involvement in a closely related joint project [13]. Finally, I am grateful to Christian Hainzl for valuable comments on an earlier version of the manuscript and Andreas Deuchert for interesting discussions.","ec_funded":1,"status":"public","article_number":"3","abstract":[{"lang":"eng","text":"We investigate the BCS critical temperature Tc in the high-density limit and derive an asymptotic formula, which strongly depends on the behavior of the interaction potential V on the Fermi-surface. Our results include a rigorous confirmation for the behavior of Tc at high densities proposed by Langmann et al. (Phys Rev Lett 122:157001, 2019) and identify precise conditions under which superconducting domes arise in BCS theory."}],"day":"11","has_accepted_license":"1","keyword":["geometry and topology","mathematical physics"],"citation":{"short":"S.J. Henheik, Mathematical Physics, Analysis and Geometry 25 (2022).","ama":"Henheik SJ. The BCS critical temperature at high density. <i>Mathematical Physics, Analysis and Geometry</i>. 2022;25(1). doi:<a href=\"https://doi.org/10.1007/s11040-021-09415-0\">10.1007/s11040-021-09415-0</a>","apa":"Henheik, S. J. (2022). The BCS critical temperature at high density. <i>Mathematical Physics, Analysis and Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11040-021-09415-0\">https://doi.org/10.1007/s11040-021-09415-0</a>","chicago":"Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” <i>Mathematical Physics, Analysis and Geometry</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s11040-021-09415-0\">https://doi.org/10.1007/s11040-021-09415-0</a>.","ista":"Henheik SJ. 2022. The BCS critical temperature at high density. Mathematical Physics, Analysis and Geometry. 25(1), 3.","ieee":"S. J. Henheik, “The BCS critical temperature at high density,” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 25, no. 1. Springer Nature, 2022.","mla":"Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 25, no. 1, 3, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s11040-021-09415-0\">10.1007/s11040-021-09415-0</a>."},"intvolume":"        25"},{"publication_identifier":{"issn":["0377-9017"],"eissn":["1573-0530"]},"article_processing_charge":"No","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"isi":1,"file":[{"access_level":"open_access","date_updated":"2022-01-19T09:41:14Z","success":1,"date_created":"2022-01-19T09:41:14Z","content_type":"application/pdf","file_id":"10647","file_name":"2022_LettersMathPhys_Henheik.pdf","creator":"cchlebak","file_size":357547,"checksum":"7e8e69b76e892c305071a4736131fe18","relation":"main_file"}],"volume":112,"year":"2022","date_created":"2022-01-18T16:18:25Z","quality_controlled":"1","project":[{"call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","grant_number":"101020331"}],"date_updated":"2023-08-02T13:57:02Z","publication":"Letters in Mathematical Physics","issue":"1","author":[{"orcid":"0000-0003-1106-327X","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","full_name":"Henheik, Sven Joscha","first_name":"Sven Joscha","last_name":"Henheik"},{"last_name":"Teufel","full_name":"Teufel, Stefan","first_name":"Stefan"},{"full_name":"Wessel, Tom","first_name":"Tom","last_name":"Wessel"}],"ddc":["530"],"oa_version":"Published Version","external_id":{"arxiv":["2106.13780"],"isi":["000744930400001"]},"date_published":"2022-01-18T00:00:00Z","arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","file_date_updated":"2022-01-19T09:41:14Z","doi":"10.1007/s11005-021-01494-y","publisher":"Springer Nature","keyword":["mathematical physics","statistical and nonlinear physics"],"intvolume":"       112","citation":{"ama":"Henheik SJ, Teufel S, Wessel T. Local stability of ground states in locally gapped and weakly interacting quantum spin systems. <i>Letters in Mathematical Physics</i>. 2022;112(1). doi:<a href=\"https://doi.org/10.1007/s11005-021-01494-y\">10.1007/s11005-021-01494-y</a>","short":"S.J. Henheik, S. Teufel, T. Wessel, Letters in Mathematical Physics 112 (2022).","ieee":"S. J. Henheik, S. Teufel, and T. Wessel, “Local stability of ground states in locally gapped and weakly interacting quantum spin systems,” <i>Letters in Mathematical Physics</i>, vol. 112, no. 1. Springer Nature, 2022.","mla":"Henheik, Sven Joscha, et al. “Local Stability of Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.” <i>Letters in Mathematical Physics</i>, vol. 112, no. 1, 9, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s11005-021-01494-y\">10.1007/s11005-021-01494-y</a>.","apa":"Henheik, S. J., Teufel, S., &#38; Wessel, T. (2022). Local stability of ground states in locally gapped and weakly interacting quantum spin systems. <i>Letters in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11005-021-01494-y\">https://doi.org/10.1007/s11005-021-01494-y</a>","ista":"Henheik SJ, Teufel S, Wessel T. 2022. Local stability of ground states in locally gapped and weakly interacting quantum spin systems. Letters in Mathematical Physics. 112(1), 9.","chicago":"Henheik, Sven Joscha, Stefan Teufel, and Tom Wessel. “Local Stability of Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.” <i>Letters in Mathematical Physics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s11005-021-01494-y\">https://doi.org/10.1007/s11005-021-01494-y</a>."},"day":"18","has_accepted_license":"1","status":"public","article_number":"9","abstract":[{"text":"Based on a result by Yarotsky (J Stat Phys 118, 2005), we prove that localized but otherwise arbitrary perturbations of weakly interacting quantum spin systems with uniformly gapped on-site terms change the ground state of such a system only locally, even if they close the spectral gap. We call this a strong version of the local perturbations perturb locally (LPPL) principle which is known to hold for much more general gapped systems, but only for perturbations that do not close the spectral gap of the Hamiltonian. We also extend this strong LPPL-principle to Hamiltonians that have the appropriate structure of gapped on-site terms and weak interactions only locally in some region of space. While our results are technically corollaries to a theorem of Yarotsky, we expect that the paradigm of systems with a locally gapped ground state that is completely insensitive to the form of the Hamiltonian elsewhere extends to other situations and has important physical consequences.","lang":"eng"}],"ec_funded":1,"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"acknowledgement":"J. H. acknowledges partial financial support by the ERC Advanced Grant “RMTBeyond” No. 101020331. S. T. thanks Marius Lemm and Simone Warzel for very helpful comments and discussions and Jürg Fröhlich for references to the literature. Open Access funding enabled and organized by Projekt DEAL.","publication_status":"published","oa":1,"title":"Local stability of ground states in locally gapped and weakly interacting quantum spin systems","article_type":"original","_id":"10642","month":"01","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"article_type":"original","oa":1,"title":"Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"10643","month":"01","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"acknowledgement":"J.H. acknowledges partial financial support by the ERC Advanced Grant ‘RMTBeyond’ No. 101020331. Support for publication costs from the Deutsche Forschungsgemeinschaft and the Open Access Publishing Fund of the University of Tübingen is gratefully acknowledged.","abstract":[{"text":"We prove a generalised super-adiabatic theorem for extended fermionic systems assuming a spectral gap only in the bulk. More precisely, we assume that the infinite system has a unique ground state and that the corresponding Gelfand–Naimark–Segal Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that a similar adiabatic theorem also holds in the bulk of finite systems up to errors that vanish faster than any inverse power of the system size, although the corresponding finite-volume Hamiltonians need not have a spectral gap.\r\n\r\n","lang":"eng"}],"article_number":"e4","status":"public","ec_funded":1,"citation":{"ama":"Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. <i>Forum of Mathematics, Sigma</i>. 2022;10. doi:<a href=\"https://doi.org/10.1017/fms.2021.80\">10.1017/fms.2021.80</a>","short":"S.J. Henheik, S. Teufel, Forum of Mathematics, Sigma 10 (2022).","ieee":"S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk,” <i>Forum of Mathematics, Sigma</i>, vol. 10. Cambridge University Press, 2022.","mla":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Gap in the Bulk.” <i>Forum of Mathematics, Sigma</i>, vol. 10, e4, Cambridge University Press, 2022, doi:<a href=\"https://doi.org/10.1017/fms.2021.80\">10.1017/fms.2021.80</a>.","chicago":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Gap in the Bulk.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2022. <a href=\"https://doi.org/10.1017/fms.2021.80\">https://doi.org/10.1017/fms.2021.80</a>.","ista":"Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. 10, e4.","apa":"Henheik, S. J., &#38; Teufel, S. (2022). Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2021.80\">https://doi.org/10.1017/fms.2021.80</a>"},"intvolume":"        10","keyword":["computational mathematics","discrete mathematics and combinatorics","geometry and topology","mathematical physics","statistics and probability","algebra and number theory","theoretical computer science","analysis"],"has_accepted_license":"1","day":"18","file_date_updated":"2022-01-19T09:27:43Z","type":"journal_article","language":[{"iso":"eng"}],"arxiv":1,"publisher":"Cambridge University Press","doi":"10.1017/fms.2021.80","ddc":["510"],"author":[{"first_name":"Sven Joscha","full_name":"Henheik, Sven Joscha","last_name":"Henheik","orcid":"0000-0003-1106-327X","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb"},{"last_name":"Teufel","full_name":"Teufel, Stefan","first_name":"Stefan"}],"publication":"Forum of Mathematics, Sigma","date_published":"2022-01-18T00:00:00Z","external_id":{"isi":["000743615000001"],"arxiv":["2012.15239"]},"oa_version":"Published Version","volume":10,"file":[{"relation":"main_file","checksum":"87592a755adcef22ea590a99dc728dd3","file_size":705323,"creator":"cchlebak","file_name":"2022_ForumMathSigma_Henheik.pdf","date_created":"2022-01-19T09:27:43Z","file_id":"10646","content_type":"application/pdf","success":1,"date_updated":"2022-01-19T09:27:43Z","access_level":"open_access"}],"isi":1,"date_updated":"2023-08-02T13:53:11Z","project":[{"call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"quality_controlled":"1","year":"2022","date_created":"2022-01-18T16:18:51Z","publication_identifier":{"eissn":["2050-5094"]},"article_processing_charge":"Yes","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"}},{"quality_controlled":"1","year":"2022","date_created":"2022-01-24T10:34:53Z","date_updated":"2025-05-26T09:05:09Z","project":[{"grant_number":"P32896","name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"}],"volume":377,"isi":1,"file":[{"access_level":"open_access","date_updated":"2022-01-24T10:34:45Z","content_type":"application/pdf","date_created":"2022-01-24T10:34:45Z","file_id":"10659","file_name":"rstb.2021.0010.pdf","creator":"oolusany","file_size":1845792,"checksum":"04ca9e2f0e344d680b947f2457df8d0a","relation":"main_file"}],"article_processing_charge":"No","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_identifier":{"issn":["0962-8436"],"eissn":["1471-2970"]},"pmid":1,"doi":"10.1098/rstb.2021.0010","publisher":"The Royal Society","language":[{"iso":"eng"}],"file_date_updated":"2022-01-24T10:34:45Z","type":"journal_article","oa_version":"Published Version","external_id":{"pmid":["35067097"],"isi":["000745854300008"]},"date_published":"2022-01-24T00:00:00Z","publication":"Philosophical Transactions of the Royal Society B","issue":"1846","ddc":["576"],"author":[{"last_name":"Sachdeva","first_name":"Himani","full_name":"Sachdeva, Himani"},{"full_name":"Olusanya, Oluwafunmilola O","first_name":"Oluwafunmilola O","last_name":"Olusanya","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1971-8314"},{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H"}],"article_number":"20210010","status":"public","abstract":[{"text":"We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’.","lang":"eng"}],"day":"24","has_accepted_license":"1","intvolume":"       377","citation":{"ieee":"H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity,” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846. The Royal Society, 2022.","mla":"Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846, 20210010, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>.","chicago":"Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>.","ista":"Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. 377(1846), 20210010.","apa":"Sachdeva, H., Olusanya, O. O., &#38; Barton, N. H. (2022). Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>","ama":"Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. 2022;377(1846). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>","short":"H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the Royal Society B 377 (2022)."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"01","_id":"10658","oa":1,"title":"Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"14711"}],"link":[{"url":"https://doi.org/10.1101/2021.08.05.455207","relation":"earlier_version"}]},"publication_status":"published","article_type":"original","acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) (grant no. P-32896B).","department":[{"_id":"GradSch"},{"_id":"NiBa"}]},{"date_created":"2022-02-04T15:45:12Z","year":"2022","date_updated":"2023-09-07T13:43:23Z","project":[{"name":"Epidemics in ant societies on a chip","grant_number":"771402","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"acknowledged_ssus":[{"_id":"LifeSc"}],"file":[{"relation":"source_file","checksum":"47ba18bb270dd6cc266e0a3f7c69d0e4","file_size":6757886,"creator":"smetzler","file_name":"Thesis_Sina_Metzler.docx","embargo_to":"open_access","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"10728","date_created":"2022-02-04T15:36:12Z","date_updated":"2023-02-03T23:30:03Z","access_level":"closed"},{"embargo":"2023-02-02","file_name":"Thesis_Sina_Metzler_A2.pdf","access_level":"open_access","date_updated":"2023-02-03T23:30:03Z","content_type":"application/pdf","file_id":"10730","date_created":"2022-02-04T15:36:43Z","checksum":"f3ec07d5d6b20ae6e46bfeedebce9027","relation":"main_file","creator":"smetzler","file_size":6314921},{"file_name":"Thesis_Sina_Metzler_print.pdf","embargo":"2023-02-02","date_created":"2022-02-07T10:35:02Z","file_id":"10742","content_type":"application/pdf","date_updated":"2023-02-04T23:30:03Z","access_level":"open_access","relation":"main_file","checksum":"dedd14b7be7a75d63018dbfc68dd8113","file_size":6882557,"creator":"smetzler"}],"article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT:ISTA:10727","publisher":"Institute of Science and Technology Austria","language":[{"iso":"eng"}],"file_date_updated":"2023-02-04T23:30:03Z","type":"dissertation","oa_version":"Published Version","date_published":"2022-02-07T00:00:00Z","ddc":["570"],"author":[{"first_name":"Sina","full_name":"Metzler, Sina","last_name":"Metzler","id":"48204546-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9547-2494"}],"degree_awarded":"PhD","ec_funded":1,"status":"public","abstract":[{"lang":"eng","text":"Social insects are a common model to study disease dynamics in social animals. Even though pathogens should thrive in social insect colonies as the hosts engage in frequent social interactions, are closely related and live in a pathogen-rich environment, disease outbreaks are rare. This is because social insects have evolved mechanisms to keep pathogens at bay – and fight disease as a collective. Social insect colonies are often viewed as “superorganisms” with division of labor between reproductive “germ-like” queens and males and “somatic” workers, which together form an interdependent reproductive unit that parallels a multicellular body. Superorganisms possess a “social immune system” that comprises of collective disease defenses performed by the workers - summarized as “social immunity”. In social groups immunization (reduced susceptibility to a parasite upon secondary exposure to the same parasite) can e.g. be triggered by social interactions (“social immunization”). Social immunization can be caused by (i) asymptomatic low-level infections that are acquired during caregiving to a contagious individual that can give an immune boost, which can induce protection upon later encounter with the same pathogen (active immunization) or (ii) by transfer of immune effectors between individuals (passive immunization).\r\nIn the second chapter, I built up on a study that I co-authored that found that low-level infections can not only be protective, but also be costly and make the host more susceptible to detrimental superinfections after contact to a very dissimilar pathogen. I here now tested different degrees of phylogenetically-distant fungal strains of M. brunneum and M. robertsii in L. neglectus and can describe the occurrence of cross-protection of social immunization if the first and second pathogen are from the same level. Interestingly, low-level infections only provided protection when the first strain was less virulent than the second strain and elicited higher immune gene expression.\r\nIn the third and fourth chapters, I expanded on the role of social immunity in sexual selection, a so far unstudied field. I used the fungus Metarhizium robertsii and the ant Cardiocondyla obscurior as a model, as in this species mating occurs in the presence of workers and can be studied under laboratory conditions. Before males mate with virgin queens in the nest they engage in fierce combat over the access to their mating partners.\r\nFirst, I focused on male-male competition in the third chapter and found that fighting with a contagious male is costly as it can lead to contamination of the rival, but that workers can decrease the risk of disease contraction by performing sanitary care.\r\nIn the fourth chapter, I studied the effect of fungal infection on survival and mating success of sexuals (freshly emerged queens and males) and found that worker-performed sanitary care can buffer the negative effect that a pathogenic contagion would have on sexuals by spore removal from the exposed individuals. When social immunity was prevented and queens could contract spores from their mating partner, very low dosages led to negative consequences: their lifespan was reduced and they produced fewer offspring with poor immunocompetence compared to healthy queens. Interestingly, cohabitation with a late-stage infected male where no spore transfer was possible had a positive effect on offspring immunity – male offspring of mothers that apparently perceived an infected partner in their vicinity reacted more sensitively to fungal challenge than male offspring without paternal pathogen history."}],"day":"07","has_accepted_license":"1","supervisor":[{"first_name":"Sylvia","full_name":"Cremer, Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"citation":{"ista":"Metzler S. 2022. Pathogen-mediated sexual selection and immunization in ant colonies. Institute of Science and Technology Austria.","chicago":"Metzler, Sina. “Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:10727\">https://doi.org/10.15479/AT:ISTA:10727</a>.","apa":"Metzler, S. (2022). <i>Pathogen-mediated sexual selection and immunization in ant colonies</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:10727\">https://doi.org/10.15479/AT:ISTA:10727</a>","mla":"Metzler, Sina. <i>Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10727\">10.15479/AT:ISTA:10727</a>.","ieee":"S. Metzler, “Pathogen-mediated sexual selection and immunization in ant colonies,” Institute of Science and Technology Austria, 2022.","short":"S. Metzler, Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies, Institute of Science and Technology Austria, 2022.","ama":"Metzler S. Pathogen-mediated sexual selection and immunization in ant colonies. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10727\">10.15479/AT:ISTA:10727</a>"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"10727","month":"02","title":"Pathogen-mediated sexual selection and immunization in ant colonies","oa":1,"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"SyCr"}],"alternative_title":["ISTA Thesis"]},{"ec_funded":1,"degree_awarded":"PhD","abstract":[{"text":"In this Thesis, I study composite quantum impurities with variational techniques, both inspired by machine learning as well as fully analytic. I supplement this with exploration of other applications of machine learning, in particular artificial neural networks, in many-body physics. In Chapters 3 and 4, I study quasiparticle systems with variational approach. I derive a Hamiltonian describing the angulon quasiparticle in the presence of a magnetic field. I apply analytic variational treatment to this Hamiltonian. Then, I introduce a variational approach for non-additive systems, based on artificial neural networks. I exemplify this approach on the example of the polaron quasiparticle (Fröhlich Hamiltonian). In Chapter 5, I continue using artificial neural networks, albeit in a different setting. I apply artificial neural networks to detect phases from snapshots of two types physical systems. Namely, I study Monte Carlo snapshots of multilayer classical spin models as well as molecular dynamics maps of colloidal systems. The main type of networks that I use here are convolutional neural networks, known for their applicability to image data.","lang":"eng"}],"status":"public","has_accepted_license":"1","day":"21","citation":{"chicago":"Rzadkowski, Wojciech. “Analytic and Machine Learning Approaches to Composite Quantum Impurities.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:10759\">https://doi.org/10.15479/at:ista:10759</a>.","ista":"Rzadkowski W. 2022. Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria.","apa":"Rzadkowski, W. (2022). <i>Analytic and machine learning approaches to composite quantum impurities</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10759\">https://doi.org/10.15479/at:ista:10759</a>","mla":"Rzadkowski, Wojciech. <i>Analytic and Machine Learning Approaches to Composite Quantum Impurities</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:10759\">10.15479/at:ista:10759</a>.","ieee":"W. Rzadkowski, “Analytic and machine learning approaches to composite quantum impurities,” Institute of Science and Technology Austria, 2022.","short":"W. Rzadkowski, Analytic and Machine Learning Approaches to Composite Quantum Impurities, Institute of Science and Technology Austria, 2022.","ama":"Rzadkowski W. Analytic and machine learning approaches to composite quantum impurities. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:10759\">10.15479/at:ista:10759</a>"},"supervisor":[{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802","first_name":"Mikhail","full_name":"Lemeshko, Mikhail","last_name":"Lemeshko"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"10759","month":"02","title":"Analytic and machine learning approaches to composite quantum impurities","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"10762"},{"id":"7956","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"415"},{"id":"8644","relation":"part_of_dissertation","status":"public"}]},"oa":1,"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"MiLe"}],"alternative_title":["ISTA Thesis"],"date_updated":"2024-08-07T07:16:53Z","project":[{"call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program"}],"page":"120","date_created":"2022-02-16T13:27:37Z","year":"2022","file":[{"creator":"wrzadkow","file_size":17668233,"checksum":"0fc54ad1eaede879c665ac9b53c93e22","relation":"source_file","date_updated":"2022-02-22T07:20:12Z","access_level":"closed","file_id":"10785","date_created":"2022-02-21T13:58:16Z","content_type":"application/zip","file_name":"Rzadkowski_thesis_final_source.zip"},{"content_type":"application/pdf","date_created":"2022-02-21T14:02:54Z","file_id":"10786","access_level":"open_access","success":1,"date_updated":"2022-02-21T14:02:54Z","file_name":"Rzadkowski_thesis_final.pdf","file_size":13307331,"creator":"wrzadkow","relation":"main_file","checksum":"22d2d7af37ca31f6b1730c26cac7bced"}],"article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"publisher":"Institute of Science and Technology Austria","doi":"10.15479/at:ista:10759","file_date_updated":"2022-02-22T07:20:12Z","type":"dissertation","language":[{"iso":"eng"}],"date_published":"2022-02-21T00:00:00Z","oa_version":"Published Version","ddc":["530"],"author":[{"full_name":"Rzadkowski, Wojciech","first_name":"Wojciech","last_name":"Rzadkowski","orcid":"0000-0002-1106-4419","id":"48C55298-F248-11E8-B48F-1D18A9856A87"}]},{"volume":377,"file":[{"relation":"main_file","checksum":"3b0243738f01bf3c07e0d7e8dc64f71d","file_size":1349672,"creator":"dernst","file_name":"2022_PhilosophicalTransactionsRSB_Barton.pdf","date_created":"2022-08-02T06:14:32Z","file_id":"11719","content_type":"application/pdf","success":1,"date_updated":"2022-08-02T06:14:32Z","access_level":"open_access"}],"isi":1,"date_updated":"2025-05-26T09:05:09Z","project":[{"name":"Causes and consequences of population fragmentation","grant_number":"P32896","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"}],"quality_controlled":"1","year":"2022","date_created":"2022-02-21T16:08:10Z","scopus_import":"1","pmid":1,"publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"article_processing_charge":"No","file_date_updated":"2022-08-02T06:14:32Z","type":"journal_article","language":[{"iso":"eng"}],"publisher":"The Royal Society","doi":"10.1098/rstb.2021.0009","ddc":["570"],"author":[{"last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"},{"last_name":"Olusanya","full_name":"Olusanya, Oluwafunmilola O","first_name":"Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1971-8314"}],"issue":"1848","publication":"Philosophical Transactions of the Royal Society B: Biological Sciences","date_published":"2022-04-11T00:00:00Z","oa_version":"Published Version","external_id":{"isi":["000758140300001"],"pmid":["35184588"]},"abstract":[{"lang":"eng","text":"A species distributed across diverse environments may adapt to local conditions. We ask how quickly such a species changes its range in response to changed conditions. Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210)) used the infinite island model to find the stationary distribution of allele frequencies and deme sizes. We extend this to find how a metapopulation responds to changes in carrying capacity, selection strength, or migration rate when deme sizes are fixed. We further develop a ‘fixed-state’ approximation. Under this approximation, polymorphism is only possible for a narrow range of habitat proportions when selection is weak compared to drift, but for a much wider range otherwise. When rates of selection or migration relative to drift change in a single deme of the metapopulation, the population takes a time of order m−1 to reach the new equilibrium. However, even with many loci, there can be substantial fluctuations in net adaptation, because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation, variation may gradually be lost by chance, even if it would persist in an infinite metapopulation. When conditions change across the whole metapopulation, there can be rapid change, which is predicted well by the fixed-state approximation. This work helps towards an understanding of how metapopulations extend their range across diverse environments.\r\nThis article is part of the theme issue ‘Species’ ranges in the face of changing environments (Part II)’."}],"status":"public","intvolume":"       377","citation":{"ieee":"N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing environment,” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848. The Royal Society, 2022.","mla":"Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>.","ista":"Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. 377(1848).","chicago":"Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>.","apa":"Barton, N. H., &#38; Olusanya, O. O. (2022). The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>","ama":"Barton NH, Olusanya OO. The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. 2022;377(1848). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>","short":"N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society B: Biological Sciences 377 (2022)."},"keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"has_accepted_license":"1","day":"11","article_type":"original","oa":1,"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"14711"}]},"title":"The response of a metapopulation to a changing environment","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"04","_id":"10787","acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) [FWF P-32896B].","department":[{"_id":"GradSch"},{"_id":"NiBa"}]},{"ec_funded":1,"degree_awarded":"PhD","abstract":[{"lang":"eng","text":"Because of the increasing popularity of machine learning methods, it is becoming important to understand the impact of learned components on automated decision-making systems and to guarantee that their consequences are beneficial to society. In other words, it is necessary to ensure that machine learning is sufficiently trustworthy to be used in real-world applications. This thesis studies two properties of machine learning models that are highly desirable for the\r\nsake of reliability: robustness and fairness. In the first part of the thesis we study the robustness of learning algorithms to training data corruption. Previous work has shown that machine learning models are vulnerable to a range\r\nof training set issues, varying from label noise through systematic biases to worst-case data manipulations. This is an especially relevant problem from a present perspective, since modern machine learning methods are particularly data hungry and therefore practitioners often have to rely on data collected from various external sources, e.g. from the Internet, from app users or via crowdsourcing. Naturally, such sources vary greatly in the quality and reliability of the\r\ndata they provide. With these considerations in mind, we study the problem of designing machine learning algorithms that are robust to corruptions in data coming from multiple sources. We show that, in contrast to the case of a single dataset with outliers, successful learning within this model is possible both theoretically and practically, even under worst-case data corruptions. The second part of this thesis deals with fairness-aware machine learning. There are multiple areas where machine learning models have shown promising results, but where careful considerations are required, in order to avoid discrimanative decisions taken by such learned components. Ensuring fairness can be particularly challenging, because real-world training datasets are expected to contain various forms of historical bias that may affect the learning process. In this thesis we show that data corruption can indeed render the problem of achieving fairness impossible, by tightly characterizing the theoretical limits of fair learning under worst-case data manipulations. However, assuming access to clean data, we also show how fairness-aware learning can be made practical in contexts beyond binary classification, in particular in the challenging learning to rank setting."}],"status":"public","has_accepted_license":"1","day":"08","citation":{"ieee":"N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute of Science and Technology Austria, 2022.","mla":"Konstantinov, Nikola H. <i>Robustness and Fairness in Machine Learning</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:10799\">10.15479/at:ista:10799</a>.","apa":"Konstantinov, N. H. (2022). <i>Robustness and fairness in machine learning</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10799\">https://doi.org/10.15479/at:ista:10799</a>","ista":"Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute of Science and Technology Austria.","chicago":"Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:10799\">https://doi.org/10.15479/at:ista:10799</a>.","ama":"Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:10799\">10.15479/at:ista:10799</a>","short":"N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute of Science and Technology Austria, 2022."},"supervisor":[{"last_name":"Lampert","first_name":"Christoph","full_name":"Lampert, Christoph","orcid":"0000-0001-8622-7887","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87"}],"keyword":["robustness","fairness","machine learning","PAC learning","adversarial learning"],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"10799","month":"03","title":"Robustness and fairness in machine learning","oa":1,"related_material":{"record":[{"id":"8724","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"10803"},{"id":"10802","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"6590"}]},"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"ChLa"}],"alternative_title":["ISTA Thesis"],"date_updated":"2023-10-17T12:31:54Z","project":[{"name":"International IST Doctoral Program","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"page":"176","year":"2022","date_created":"2022-02-28T13:03:49Z","file":[{"file_name":"thesis.pdf","file_id":"10823","content_type":"application/pdf","date_created":"2022-03-06T11:42:54Z","date_updated":"2022-03-06T11:42:54Z","success":1,"access_level":"open_access","relation":"main_file","checksum":"626bc523ae8822d20e635d0e2d95182e","file_size":4204905,"creator":"nkonstan"},{"date_updated":"2022-03-10T12:11:48Z","access_level":"closed","content_type":"application/x-zip-compressed","date_created":"2022-03-06T11:42:57Z","file_id":"10824","file_name":"thesis.zip","creator":"nkonstan","file_size":22841103,"checksum":"e2ca2b88350ac8ea1515b948885cbcb1","relation":"source_file"}],"article_processing_charge":"No","publication_identifier":{"isbn":["978-3-99078-015-2"],"issn":["2663-337X"]},"publisher":"Institute of Science and Technology Austria","doi":"10.15479/at:ista:10799","file_date_updated":"2022-03-10T12:11:48Z","type":"dissertation","language":[{"iso":"eng"}],"date_published":"2022-03-08T00:00:00Z","oa_version":"Published Version","ddc":["000"],"author":[{"id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87","last_name":"Konstantinov","full_name":"Konstantinov, Nikola H","first_name":"Nikola H"}]},{"publisher":"Springer Nature","doi":"10.1007/s12095-022-00557-8","type":"journal_article","language":[{"iso":"eng"}],"date_published":"2022-07-01T00:00:00Z","oa_version":"None","external_id":{"isi":["000766422000002"]},"author":[{"id":"8ba3170d-dc85-11ea-9058-c4251c96a6eb","last_name":"Köse","full_name":"Köse, Seyda","first_name":"Seyda"},{"full_name":"Özbudak, Ferruh","first_name":"Ferruh","last_name":"Özbudak"}],"publication":"Cryptography and Communications","issue":"4","date_updated":"2023-09-05T15:35:55Z","year":"2022","date_created":"2022-03-10T12:16:19Z","quality_controlled":"1","page":"933-948","isi":1,"volume":14,"article_processing_charge":"No","scopus_import":"1","publication_identifier":{"issn":["1936-2447"],"eissn":["1936-2455"]},"month":"07","_id":"10842","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_type":"original","publication_status":"published","title":"Factorization of some polynomials over finite local commutative rings and applications to certain self-dual and LCD codes","acknowledgement":"The authors would like to thank Prof. Dr. Minjia Shi for bringing [13, Conjecture 3.5] to our attention. We would also like to thank the associate editor and anonymous reviewers for their valuable comments and suggestions which improved and clarified the manuscript.","department":[{"_id":"GradSch"}],"abstract":[{"text":"We determine the unique factorization of some polynomials over a finite local commutative ring with identity explicitly. This solves and generalizes the main conjecture of Qian, Shi and Solé in [13]. We also give some applications to enumeration of certain generalized double circulant self-dual and linear complementary dual (LCD) codes over some finite rings together with an application in asymptotic coding theory.","lang":"eng"}],"status":"public","day":"01","intvolume":"        14","citation":{"short":"S. Köse, F. Özbudak, Cryptography and Communications 14 (2022) 933–948.","ama":"Köse S, Özbudak F. Factorization of some polynomials over finite local commutative rings and applications to certain self-dual and LCD codes. <i>Cryptography and Communications</i>. 2022;14(4):933-948. doi:<a href=\"https://doi.org/10.1007/s12095-022-00557-8\">10.1007/s12095-022-00557-8</a>","apa":"Köse, S., &#38; Özbudak, F. (2022). Factorization of some polynomials over finite local commutative rings and applications to certain self-dual and LCD codes. <i>Cryptography and Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s12095-022-00557-8\">https://doi.org/10.1007/s12095-022-00557-8</a>","chicago":"Köse, Seyda, and Ferruh Özbudak. “Factorization of Some Polynomials over Finite Local Commutative Rings and Applications to Certain Self-Dual and LCD Codes.” <i>Cryptography and Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s12095-022-00557-8\">https://doi.org/10.1007/s12095-022-00557-8</a>.","ista":"Köse S, Özbudak F. 2022. Factorization of some polynomials over finite local commutative rings and applications to certain self-dual and LCD codes. Cryptography and Communications. 14(4), 933–948.","mla":"Köse, Seyda, and Ferruh Özbudak. “Factorization of Some Polynomials over Finite Local Commutative Rings and Applications to Certain Self-Dual and LCD Codes.” <i>Cryptography and Communications</i>, vol. 14, no. 4, Springer Nature, 2022, pp. 933–48, doi:<a href=\"https://doi.org/10.1007/s12095-022-00557-8\">10.1007/s12095-022-00557-8</a>.","ieee":"S. Köse and F. Özbudak, “Factorization of some polynomials over finite local commutative rings and applications to certain self-dual and LCD codes,” <i>Cryptography and Communications</i>, vol. 14, no. 4. Springer Nature, pp. 933–948, 2022."},"keyword":["Applied Mathematics","Computational Theory and Mathematics","Computer Networks and Communications"]},{"publisher":"Elsevier","doi":"10.1016/j.jfa.2022.109455","file_date_updated":"2022-08-02T10:37:55Z","type":"journal_article","arxiv":1,"language":[{"iso":"eng"}],"date_published":"2022-06-15T00:00:00Z","oa_version":"Published Version","external_id":{"isi":["000795160200009"],"arxiv":["2105.04874"]},"ddc":["510"],"author":[{"orcid":"0000-0002-9071-5880","id":"5DA90512-D80F-11E9-8994-2E2EE6697425","first_name":"Barbara","full_name":"Roos, Barbara","last_name":"Roos"},{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert","full_name":"Seiringer, Robert"}],"publication":"Journal of Functional Analysis","issue":"12","date_updated":"2023-10-27T10:37:29Z","project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","grant_number":"694227","call_identifier":"H2020"}],"quality_controlled":"1","year":"2022","date_created":"2022-03-16T08:41:53Z","volume":282,"file":[{"checksum":"63efcefaa1f2717244ef5407bd564426","relation":"main_file","creator":"dernst","file_size":631391,"file_name":"2022_JourFunctionalAnalysis_Roos.pdf","access_level":"open_access","date_updated":"2022-08-02T10:37:55Z","success":1,"content_type":"application/pdf","file_id":"11720","date_created":"2022-08-02T10:37:55Z"}],"isi":1,"article_processing_charge":"Yes (via OA deal)","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"scopus_import":"1","publication_identifier":{"issn":["0022-1236"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"06","_id":"10850","article_type":"original","oa":1,"title":"Two-particle bound states at interfaces and corners","related_material":{"record":[{"id":"14374","relation":"dissertation_contains","status":"public"}]},"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"RoSe"}],"acknowledgement":"We thank Rupert Frank for contributing Appendix B. Funding from the European Union's Horizon 2020 research and innovation programme under the ERC grant agreement No. 694227 is gratefully acknowledged.","ec_funded":1,"abstract":[{"text":"We study two interacting quantum particles forming a bound state in d-dimensional free\r\nspace, and constrain the particles in k directions to (0, ∞)k ×Rd−k, with Neumann boundary\r\nconditions. First, we prove that the ground state energy strictly decreases upon going from k\r\nto k+1. This shows that the particles stick to the corner where all boundary planes intersect.\r\nSecond, we show that for all k the resulting Hamiltonian, after removing the free part of the\r\nkinetic energy, has only finitely many eigenvalues below the essential spectrum. This paper\r\ngeneralizes the work of Egger, Kerner and Pankrashkin (J. Spectr. Theory 10(4):1413–1444,\r\n2020) to dimensions d > 1.","lang":"eng"}],"article_number":"109455","status":"public","has_accepted_license":"1","day":"15","intvolume":"       282","citation":{"ieee":"B. Roos and R. Seiringer, “Two-particle bound states at interfaces and corners,” <i>Journal of Functional Analysis</i>, vol. 282, no. 12. Elsevier, 2022.","mla":"Roos, Barbara, and Robert Seiringer. “Two-Particle Bound States at Interfaces and Corners.” <i>Journal of Functional Analysis</i>, vol. 282, no. 12, 109455, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.jfa.2022.109455\">10.1016/j.jfa.2022.109455</a>.","chicago":"Roos, Barbara, and Robert Seiringer. “Two-Particle Bound States at Interfaces and Corners.” <i>Journal of Functional Analysis</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.jfa.2022.109455\">https://doi.org/10.1016/j.jfa.2022.109455</a>.","apa":"Roos, B., &#38; Seiringer, R. (2022). Two-particle bound states at interfaces and corners. <i>Journal of Functional Analysis</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jfa.2022.109455\">https://doi.org/10.1016/j.jfa.2022.109455</a>","ista":"Roos B, Seiringer R. 2022. Two-particle bound states at interfaces and corners. Journal of Functional Analysis. 282(12), 109455.","ama":"Roos B, Seiringer R. Two-particle bound states at interfaces and corners. <i>Journal of Functional Analysis</i>. 2022;282(12). doi:<a href=\"https://doi.org/10.1016/j.jfa.2022.109455\">10.1016/j.jfa.2022.109455</a>","short":"B. Roos, R. Seiringer, Journal of Functional Analysis 282 (2022)."},"keyword":["Analysis"]}]
