[{"date_published":"2016-03-01T00:00:00Z","type":"conference","volume":43,"oa_version":"Published Version","article_processing_charge":"No","doi":"10.22489/cinc.2016.090-500","date_updated":"2022-03-04T07:34:45Z","publisher":"Computing in Cardiology","publication":"2016 Computing in Cardiology Conference","month":"03","oa":1,"quality_controlled":"1","author":[{"first_name":"Paul","full_name":"Rubel, Paul","last_name":"Rubel"},{"first_name":"Danilo","full_name":"Pani, Danilo","last_name":"Pani"},{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","full_name":"Schlögl, Alois","last_name":"Schlögl","orcid":"0000-0002-5621-8100"},{"last_name":"Fayn","first_name":"Jocelyne","full_name":"Fayn, Jocelyne"},{"last_name":"Badilini","full_name":"Badilini, Fabio","first_name":"Fabio"},{"last_name":"Macfarlane","first_name":"Peter","full_name":"Macfarlane, Peter"},{"first_name":"Alpo","full_name":"Varri, Alpo","last_name":"Varri"}],"conference":{"end_date":"2016-09-14","location":"Vancouver, Canada","name":"CinC: Computing in Cardiology","start_date":"2016-09-11"},"page":"309-312","date_created":"2022-03-03T10:43:10Z","day":"01","publication_status":"published","language":[{"iso":"eng"}],"year":"2016","department":[{"_id":"CampIT"}],"status":"public","intvolume":"        43","citation":{"chicago":"Rubel, Paul, Danilo Pani, Alois Schlögl, Jocelyne Fayn, Fabio Badilini, Peter Macfarlane, and Alpo Varri. “SCP-ECG V3.0: An Enhanced Standard Communication Protocol for Computer-Assisted Electrocardiography.” In <i>2016 Computing in Cardiology Conference</i>, 43:309–12. Computing in Cardiology, 2016. <a href=\"https://doi.org/10.22489/cinc.2016.090-500\">https://doi.org/10.22489/cinc.2016.090-500</a>.","mla":"Rubel, Paul, et al. “SCP-ECG V3.0: An Enhanced Standard Communication Protocol for Computer-Assisted Electrocardiography.” <i>2016 Computing in Cardiology Conference</i>, vol. 43, Computing in Cardiology, 2016, pp. 309–12, doi:<a href=\"https://doi.org/10.22489/cinc.2016.090-500\">10.22489/cinc.2016.090-500</a>.","ama":"Rubel P, Pani D, Schlögl A, et al. SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography. In: <i>2016 Computing in Cardiology Conference</i>. Vol 43. Computing in Cardiology; 2016:309-312. doi:<a href=\"https://doi.org/10.22489/cinc.2016.090-500\">10.22489/cinc.2016.090-500</a>","ieee":"P. Rubel <i>et al.</i>, “SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography,” in <i>2016 Computing in Cardiology Conference</i>, Vancouver, Canada, 2016, vol. 43, pp. 309–312.","short":"P. Rubel, D. Pani, A. Schlögl, J. Fayn, F. Badilini, P. Macfarlane, A. Varri, in:, 2016 Computing in Cardiology Conference, Computing in Cardiology, 2016, pp. 309–312.","apa":"Rubel, P., Pani, D., Schlögl, A., Fayn, J., Badilini, F., Macfarlane, P., &#38; Varri, A. (2016). SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography. In <i>2016 Computing in Cardiology Conference</i> (Vol. 43, pp. 309–312). Vancouver, Canada: Computing in Cardiology. <a href=\"https://doi.org/10.22489/cinc.2016.090-500\">https://doi.org/10.22489/cinc.2016.090-500</a>","ista":"Rubel P, Pani D, Schlögl A, Fayn J, Badilini F, Macfarlane P, Varri A. 2016. SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography. 2016 Computing in Cardiology Conference. CinC: Computing in Cardiology vol. 43, 309–312."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.22489/cinc.2016.090-500"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"The main goal of the SCP-ECG standard is to address ECG data and related metadata structuring, semantics and syntax, with the objective of facilitating interoperability and thus supporting and promoting the exchange of the relevant information for unary and serial ECG diagnosis. Starting with version V3.0, the standard now also provides support for the storage of continuous, long-term ECG recordings and affords a repository for selected ECG sequences and the related metadata to accommodate stress tests, drug trials and protocol-based ECG recordings. The global and per-lead measurements sections have been extended and three new sections have been introduced for storing beat-by-beat and/or spike-by-spike measurements\r\nand annotations. The used terminology and the provided measurements and annotations have been harmonized with the ISO/IEEE 11073-10102 Annotated ECG standard. Emphasis has also been put on harmonizing the Universal Statement Codes with the CDISC and the categorized AHA statement codes and similarly the drug and implanted devices codes with the ATC and NASPE/BPEG codes. "}],"title":"SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography","_id":"10810","acknowledgement":"The authors are thankful to Drs. Roger Abaecherli, Nikus Kjell, Paul Kligfield, Jay Mason, Patrice Nony, Vito Starc, Anders Thurin and the late Galen Wagner for their in depth review and constructive comments.","publication_identifier":{"issn":["2325-887X"]},"scopus_import":"1"},{"_id":"1154","title":"A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients","abstract":[{"text":"Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. To encode for direction, every cue must be present as a spatial or temporal gradient. Here, we developed a microfluidic chamber that allows measurement of cell migration in combined response to surface immobilized and soluble molecular gradients. As a proof of principle we study the response of dendritic cells to their major guidance cues, chemokines. The majority of data on chemokine gradient sensing is based on in vitro studies employing soluble gradients. Despite evidence suggesting that in vivo chemokines are often immobilized to sugar residues, limited information is available how cells respond to immobilized chemokines. We tracked migration of dendritic cells towards immobilized gradients of the chemokine CCL21 and varying superimposed soluble gradients of CCL19. Differential migratory patterns illustrate the potential of our setup to quantitatively study the competitive response to both types of gradients. Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and haptotaxis such as cells migrating along gradients of adhesion receptor ligands vs. any soluble cue. \r\n","lang":"eng"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by the Swiss National Science Foundation (Ambizione fellowship; PZ00P3-154733 to M.M.), the Swiss Multiple Sclerosis Society (research support to M.M.), a fellowship from the Boehringer Ingelheim Fonds (BIF) to J.S., the European Research Council (grant ERC GA 281556) and a START award from the Austrian Science Foundation (FWF) to M.S. #BioimagingFacility","ec_funded":1,"status":"public","has_accepted_license":"1","citation":{"ieee":"J. Schwarz <i>et al.</i>, “A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients,” <i>Scientific Reports</i>, vol. 6. Nature Publishing Group, 2016.","short":"J. Schwarz, V. Bierbaum, J. Merrin, T. Frank, R. Hauschild, M.T. Bollenbach, S. Tay, M.K. Sixt, M. Mehling, Scientific Reports 6 (2016).","ista":"Schwarz J, Bierbaum V, Merrin J, Frank T, Hauschild R, Bollenbach MT, Tay S, Sixt MK, Mehling M. 2016. A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients. Scientific Reports. 6, 36440.","apa":"Schwarz, J., Bierbaum, V., Merrin, J., Frank, T., Hauschild, R., Bollenbach, M. T., … Mehling, M. (2016). A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/srep36440\">https://doi.org/10.1038/srep36440</a>","chicago":"Schwarz, Jan, Veronika Bierbaum, Jack Merrin, Tino Frank, Robert Hauschild, Mark Tobias Bollenbach, Savaş Tay, Michael K Sixt, and Matthias Mehling. “A Microfluidic Device for Measuring Cell Migration towards Substrate Bound and Soluble Chemokine Gradients.” <i>Scientific Reports</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/srep36440\">https://doi.org/10.1038/srep36440</a>.","ama":"Schwarz J, Bierbaum V, Merrin J, et al. A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients. <i>Scientific Reports</i>. 2016;6. doi:<a href=\"https://doi.org/10.1038/srep36440\">10.1038/srep36440</a>","mla":"Schwarz, Jan, et al. “A Microfluidic Device for Measuring Cell Migration towards Substrate Bound and Soluble Chemokine Gradients.” <i>Scientific Reports</i>, vol. 6, 36440, Nature Publishing Group, 2016, doi:<a href=\"https://doi.org/10.1038/srep36440\">10.1038/srep36440</a>."},"intvolume":"         6","scopus_import":1,"file_date_updated":"2018-12-12T10:09:32Z","publication":"Scientific Reports","doi":"10.1038/srep36440","date_updated":"2021-01-12T06:48:41Z","publisher":"Nature Publishing Group","article_number":"36440","quality_controlled":"1","oa":1,"file":[{"file_id":"4756","date_created":"2018-12-12T10:09:32Z","content_type":"application/pdf","creator":"system","relation":"main_file","access_level":"open_access","file_name":"IST-2017-744-v1+1_srep36440.pdf","file_size":2353456,"date_updated":"2018-12-12T10:09:32Z"}],"month":"11","volume":6,"date_published":"2016-11-07T00:00:00Z","type":"journal_article","project":[{"name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","call_identifier":"FP7","grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425"},{"_id":"25A8E5EA-B435-11E9-9278-68D0E5697425","grant_number":"Y 564-B12","name":"Cytoskeletal force generation and transduction of leukocytes (FWF)","call_identifier":"FWF"}],"oa_version":"Published Version","year":"2016","ddc":["579"],"language":[{"iso":"eng"}],"department":[{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"Bio"},{"_id":"ToBo"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pubrep_id":"744","author":[{"full_name":"Schwarz, Jan","id":"346C1EC6-F248-11E8-B48F-1D18A9856A87","first_name":"Jan","last_name":"Schwarz"},{"full_name":"Bierbaum, Veronika","first_name":"Veronika","id":"3FD04378-F248-11E8-B48F-1D18A9856A87","last_name":"Bierbaum"},{"id":"4515C308-F248-11E8-B48F-1D18A9856A87","first_name":"Jack","full_name":"Merrin, Jack","last_name":"Merrin","orcid":"0000-0001-5145-4609"},{"last_name":"Frank","first_name":"Tino","full_name":"Frank, Tino"},{"last_name":"Hauschild","orcid":"0000-0001-9843-3522","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Hauschild, Robert"},{"full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Mark Tobias","last_name":"Bollenbach","orcid":"0000-0003-4398-476X"},{"last_name":"Tay","full_name":"Tay, Savaş","first_name":"Savaş"},{"first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt"},{"full_name":"Mehling, Matthias","id":"3C23B994-F248-11E8-B48F-1D18A9856A87","first_name":"Matthias","last_name":"Mehling","orcid":"0000-0001-8599-1226"}],"publist_id":"6204","publication_status":"published","day":"07","date_created":"2018-12-11T11:50:27Z"},{"file":[{"date_created":"2018-12-12T10:17:59Z","file_id":"5317","content_type":"application/pdf","relation":"main_file","creator":"system","checksum":"a495fe253bbc7615b1d60e9e85c94408","file_name":"IST-2016-720-v1+1_OANA_OA-Empfehlungen_12-11-2015.pdf","access_level":"open_access","file_size":931707,"date_updated":"2020-07-14T12:45:00Z"}],"oa":1,"quality_controlled":"1","month":"11","date_updated":"2021-01-12T06:51:22Z","publisher":"Verein Österreichischer Bibliothekare","doi":"10.5281/zenodo.33178","publication":"VÖB Mitteilungen","article_processing_charge":"No","oa_version":"Published Version","article_type":"original","type":"journal_article","date_published":"2015-11-12T00:00:00Z","volume":68,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"E-Lib"}],"ddc":["020"],"language":[{"iso":"eng"}],"year":"2015","day":"12","publist_id":"5648","publication_status":"published","date_created":"2018-12-11T11:52:31Z","page":"580 - 607","author":[{"last_name":"Bauer","full_name":"Bauer, Bruno","first_name":"Bruno"},{"last_name":"Blechl","full_name":"Blechl, Guido","first_name":"Guido"},{"last_name":"Bock","full_name":"Bock, Christoph","first_name":"Christoph"},{"last_name":"Danowski","orcid":"0000-0002-6026-4409","full_name":"Danowski, Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","first_name":"Patrick"},{"last_name":"Ferus","first_name":"Andreas","full_name":"Ferus, Andreas"},{"last_name":"Graschopf","full_name":"Graschopf, Anton","first_name":"Anton"},{"last_name":"König","first_name":"Thomas","full_name":"König, Thomas"},{"last_name":"Mayer","full_name":"Mayer, Katja","first_name":"Katja"},{"full_name":"Reckling, Falk","first_name":"Falk","last_name":"Reckling"},{"last_name":"Rieck","full_name":"Rieck, Katharina","first_name":"Katharina"},{"full_name":"Seitz, Peter","first_name":"Peter","last_name":"Seitz"},{"last_name":"Stöger","first_name":"Herwig","full_name":"Stöger, Herwig"},{"last_name":"Welzig","full_name":"Welzig, Elvira","first_name":"Elvira"}],"pubrep_id":"720","title":"Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA","_id":"1525","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Based on 16 recommendations, efforts should be made to achieve the following goal: By 2025, all scholarly publication activity in Austria should be Open Access. In other words, the final versions of all scholarly publications resulting from the support of public resources must be freely accessible on the Internet without delay (Gold Open Access). The resources required to meet this obligation shall be provided to the authors, or the cost of the publication venues shall be borne directly by the research organisations."}],"intvolume":"        68","citation":{"short":"B. Bauer, G. Blechl, C. Bock, P. Danowski, A. Ferus, A. Graschopf, T. König, K. Mayer, F. Reckling, K. Rieck, P. Seitz, H. Stöger, E. Welzig, VÖB Mitteilungen 68 (2015) 580–607.","ieee":"B. Bauer <i>et al.</i>, “Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA,” <i>VÖB Mitteilungen</i>, vol. 68, no. 3. Verein Österreichischer Bibliothekare, pp. 580–607, 2015.","ista":"Bauer B, Blechl G, Bock C, Danowski P, Ferus A, Graschopf A, König T, Mayer K, Reckling F, Rieck K, Seitz P, Stöger H, Welzig E. 2015. Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA. VÖB Mitteilungen. 68(3), 580–607.","apa":"Bauer, B., Blechl, G., Bock, C., Danowski, P., Ferus, A., Graschopf, A., … Welzig, E. (2015). Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA. <i>VÖB Mitteilungen</i>. Verein Österreichischer Bibliothekare. <a href=\"https://doi.org/10.5281/zenodo.33178\">https://doi.org/10.5281/zenodo.33178</a>","chicago":"Bauer, Bruno, Guido Blechl, Christoph Bock, Patrick Danowski, Andreas Ferus, Anton Graschopf, Thomas König, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network Austria OANA.” <i>VÖB Mitteilungen</i>. Verein Österreichischer Bibliothekare, 2015. <a href=\"https://doi.org/10.5281/zenodo.33178\">https://doi.org/10.5281/zenodo.33178</a>.","ama":"Bauer B, Blechl G, Bock C, et al. Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA. <i>VÖB Mitteilungen</i>. 2015;68(3):580-607. doi:<a href=\"https://doi.org/10.5281/zenodo.33178\">10.5281/zenodo.33178</a>","mla":"Bauer, Bruno, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network Austria OANA.” <i>VÖB Mitteilungen</i>, vol. 68, no. 3, Verein Österreichischer Bibliothekare, 2015, pp. 580–607, doi:<a href=\"https://doi.org/10.5281/zenodo.33178\">10.5281/zenodo.33178</a>."},"has_accepted_license":"1","status":"public","file_date_updated":"2020-07-14T12:45:00Z","scopus_import":1,"issue":"3"},{"issue":"16","scopus_import":1,"intvolume":"        66","citation":{"short":"P. Grones, X. Chen, S. Simon, W. Kaufmann, R. De Rycke, T. Nodzyński, E. Zažímalová, J. Friml, Journal of Experimental Botany 66 (2015) 5055–5065.","ieee":"P. Grones <i>et al.</i>, “Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental roles,” <i>Journal of Experimental Botany</i>, vol. 66, no. 16. Oxford University Press, pp. 5055–5065, 2015.","apa":"Grones, P., Chen, X., Simon, S., Kaufmann, W., De Rycke, R., Nodzyński, T., … Friml, J. (2015). Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental roles. <i>Journal of Experimental Botany</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jxb/erv177\">https://doi.org/10.1093/jxb/erv177</a>","ista":"Grones P, Chen X, Simon S, Kaufmann W, De Rycke R, Nodzyński T, Zažímalová E, Friml J. 2015. Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental roles. Journal of Experimental Botany. 66(16), 5055–5065.","chicago":"Grones, Peter, Xu Chen, Sibu Simon, Walter Kaufmann, Riet De Rycke, Tomasz Nodzyński, Eva Zažímalová, and Jiří Friml. “Auxin-Binding Pocket of ABP1 Is Crucial for Its Gain-of-Function Cellular and Developmental Roles.” <i>Journal of Experimental Botany</i>. Oxford University Press, 2015. <a href=\"https://doi.org/10.1093/jxb/erv177\">https://doi.org/10.1093/jxb/erv177</a>.","mla":"Grones, Peter, et al. “Auxin-Binding Pocket of ABP1 Is Crucial for Its Gain-of-Function Cellular and Developmental Roles.” <i>Journal of Experimental Botany</i>, vol. 66, no. 16, Oxford University Press, 2015, pp. 5055–65, doi:<a href=\"https://doi.org/10.1093/jxb/erv177\">10.1093/jxb/erv177</a>.","ama":"Grones P, Chen X, Simon S, et al. Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental roles. <i>Journal of Experimental Botany</i>. 2015;66(16):5055-5065. doi:<a href=\"https://doi.org/10.1093/jxb/erv177\">10.1093/jxb/erv177</a>"},"ec_funded":1,"status":"public","acknowledgement":"This work was supported by ERC Independent Research grant (ERC-2011-StG- 20101109-PSDP to JF); the European Social Fund and the state budget of the Czech Republic [the project ‘Employment of Newly Graduated Doctors of Science for Scientific Excellence’ (CZ.1.07/2.3.00/30.0009) to TN]; the Czech Science Foundation (GACR) [project 13-40637S to JF].","abstract":[{"text":"The plant hormone auxin is a key regulator of plant growth and development. Auxin levels are sensed and interpreted by distinct receptor systems that activate a broad range of cellular responses. The Auxin-Binding Protein1 (ABP1) that has been identified based on its ability to bind auxin with high affinity is a prime candidate for the extracellular receptor responsible for mediating a range of auxin effects, in particular, the fast non-transcriptional ones. Contradictory genetic studies suggested prominent or no importance of ABP1 in many developmental processes. However, how crucial the role of auxin binding to ABP1 is for its functions has not been addressed. Here, we show that the auxin-binding pocket of ABP1 is essential for its gain-of-function cellular and developmental roles. In total, 16 different abp1 mutants were prepared that possessed substitutions in the metal core or in the hydrophobic amino acids of the auxin-binding pocket as well as neutral mutations. Their analysis revealed that an intact auxin-binding pocket is a prerequisite for ABP1 to activate downstream components of the ABP1 signalling pathway, such as Rho of Plants (ROPs) and to mediate the clathrin association with membranes for endocytosis regulation. In planta analyses demonstrated the importance of the auxin binding pocket for all known ABP1-mediated postembryonic developmental processes, including morphology of leaf epidermal cells, root growth and root meristem activity, and vascular tissue differentiation. Taken together, these findings suggest that auxin binding to ABP1 is central to its function, supporting the role of ABP1 as auxin receptor.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1562","title":"Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental roles","date_created":"2018-12-11T11:52:44Z","publication_status":"published","publist_id":"5609","day":"01","author":[{"last_name":"Grones","full_name":"Grones, Peter","id":"399876EC-F248-11E8-B48F-1D18A9856A87","first_name":"Peter"},{"last_name":"Chen","first_name":"Xu","id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","full_name":"Chen, Xu"},{"first_name":"Sibu","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87","full_name":"Simon, Sibu","orcid":"0000-0002-1998-6741","last_name":"Simon"},{"full_name":"Kaufmann, Walter","first_name":"Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","orcid":"0000-0001-9735-5315"},{"last_name":"De Rycke","full_name":"De Rycke, Riet","first_name":"Riet"},{"first_name":"Tomasz","full_name":"Nodzyński, Tomasz","last_name":"Nodzyński"},{"full_name":"Zažímalová, Eva","first_name":"Eva","last_name":"Zažímalová"},{"full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml","orcid":"0000-0002-8302-7596"}],"page":"5055 - 5065","department":[{"_id":"JiFr"},{"_id":"EM-Fac"}],"language":[{"iso":"eng"}],"year":"2015","oa_version":"None","article_type":"original","volume":66,"type":"journal_article","project":[{"name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7","_id":"25716A02-B435-11E9-9278-68D0E5697425","grant_number":"282300"}],"date_published":"2015-08-01T00:00:00Z","month":"08","quality_controlled":"1","publication":"Journal of Experimental Botany","date_updated":"2023-02-23T10:04:26Z","doi":"10.1093/jxb/erv177","publisher":"Oxford University Press"},{"issue":"12","file_date_updated":"2020-07-14T12:45:12Z","scopus_import":1,"intvolume":"        11","citation":{"chicago":"Inglés Prieto, Álvaro, Eva Gschaider-Reichhart, Markus Muellner, Matthias Nowak, Sebastian Nijman, Michael Grusch, and Harald L Janovjak. “Light-Assisted Small-Molecule Screening against Protein Kinases.” <i>Nature Chemical Biology</i>. Nature Publishing Group, 2015. <a href=\"https://doi.org/10.1038/nchembio.1933\">https://doi.org/10.1038/nchembio.1933</a>.","mla":"Inglés Prieto, Álvaro, et al. “Light-Assisted Small-Molecule Screening against Protein Kinases.” <i>Nature Chemical Biology</i>, vol. 11, no. 12, Nature Publishing Group, 2015, pp. 952–54, doi:<a href=\"https://doi.org/10.1038/nchembio.1933\">10.1038/nchembio.1933</a>.","ama":"Inglés Prieto Á, Gschaider-Reichhart E, Muellner M, et al. Light-assisted small-molecule screening against protein kinases. <i>Nature Chemical Biology</i>. 2015;11(12):952-954. doi:<a href=\"https://doi.org/10.1038/nchembio.1933\">10.1038/nchembio.1933</a>","ieee":"Á. Inglés Prieto <i>et al.</i>, “Light-assisted small-molecule screening against protein kinases,” <i>Nature Chemical Biology</i>, vol. 11, no. 12. Nature Publishing Group, pp. 952–954, 2015.","short":"Á. Inglés Prieto, E. Gschaider-Reichhart, M. Muellner, M. Nowak, S. Nijman, M. Grusch, H.L. Janovjak, Nature Chemical Biology 11 (2015) 952–954.","apa":"Inglés Prieto, Á., Gschaider-Reichhart, E., Muellner, M., Nowak, M., Nijman, S., Grusch, M., &#38; Janovjak, H. L. (2015). Light-assisted small-molecule screening against protein kinases. <i>Nature Chemical Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nchembio.1933\">https://doi.org/10.1038/nchembio.1933</a>","ista":"Inglés Prieto Á, Gschaider-Reichhart E, Muellner M, Nowak M, Nijman S, Grusch M, Janovjak HL. 2015. Light-assisted small-molecule screening against protein kinases. Nature Chemical Biology. 11(12), 952–954."},"has_accepted_license":"1","status":"public","ec_funded":1,"acknowledgement":"This work was supported by grants from the European Union Seventh Framework Programme (CIG-303564 to H.J. and ERC-StG-311166 to S.M.B.N.), the Human Frontier Science Program (RGY0084_2012 to H.J.) and the Herzfelder Foundation (to M.G.). A.I.-P. was supported by a Ramon Areces fellowship, and E.R. by the graduate program MolecularDrugTargets (Austrian Science Fund (FWF): W 1232) and a FemTech fellowship (3580812 Austrian Research Promotion Agency).","title":"Light-assisted small-molecule screening against protein kinases","_id":"1678","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"High-throughput live-cell screens are intricate elements of systems biology studies and drug discovery pipelines. Here, we demonstrate an optogenetics-assisted method that avoids the need for chemical activators and reporters, reduces the number of operational steps and increases information content in a cell-based small-molecule screen against human protein kinases, including an orphan receptor tyrosine kinase. This blueprint for all-optical screening can be adapted to many drug targets and cellular processes."}],"day":"12","publist_id":"5471","publication_status":"published","date_created":"2018-12-11T11:53:25Z","page":"952 - 954","author":[{"first_name":"Álvaro","id":"2A9DB292-F248-11E8-B48F-1D18A9856A87","full_name":"Inglés Prieto, Álvaro","last_name":"Inglés Prieto","orcid":"0000-0002-5409-8571"},{"full_name":"Gschaider-Reichhart, Eva","first_name":"Eva","id":"3FEE232A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7218-7738","last_name":"Gschaider-Reichhart"},{"full_name":"Muellner, Markus","first_name":"Markus","last_name":"Muellner"},{"id":"30845DAA-F248-11E8-B48F-1D18A9856A87","first_name":"Matthias","full_name":"Nowak, Matthias","last_name":"Nowak"},{"last_name":"Nijman","first_name":"Sebastian","full_name":"Nijman, Sebastian"},{"last_name":"Grusch","full_name":"Grusch, Michael","first_name":"Michael"},{"orcid":"0000-0002-8023-9315","last_name":"Janovjak","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","first_name":"Harald L","full_name":"Janovjak, Harald L"}],"pubrep_id":"837","department":[{"_id":"HaJa"},{"_id":"LifeSc"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"418"}]},"ddc":["571"],"language":[{"iso":"eng"}],"year":"2015","oa_version":"Submitted Version","type":"journal_article","project":[{"_id":"25548C20-B435-11E9-9278-68D0E5697425","grant_number":"303564","name":"Microbial Ion Channels for Synthetic Neurobiology","call_identifier":"FP7"},{"name":"In situ real-time imaging of neurotransmitter signaling using designer optical sensors (HFSP Young Investigator)","_id":"255BFFFA-B435-11E9-9278-68D0E5697425","grant_number":"RGY0084/2012"},{"_id":"255A6082-B435-11E9-9278-68D0E5697425","grant_number":"W1232-B24","call_identifier":"FWF","name":"Molecular Drug Targets"}],"date_published":"2015-10-12T00:00:00Z","volume":11,"oa":1,"quality_controlled":"1","file":[{"file_size":1308364,"date_updated":"2020-07-14T12:45:12Z","checksum":"e9fb251dfcb7cd209b83f17867e61321","access_level":"open_access","file_name":"IST-2017-837-v1+1_ingles-prieto.pdf","relation":"main_file","creator":"system","file_id":"4842","date_created":"2018-12-12T10:10:51Z","content_type":"application/pdf"}],"month":"10","doi":"10.1038/nchembio.1933","date_updated":"2023-09-07T12:49:09Z","publisher":"Nature Publishing Group","publication":"Nature Chemical Biology"},{"article_processing_charge":"No","publication":"International Journal of Cancer","publisher":"Wiley","doi":"10.1002/ijc.29498","date_updated":"2021-01-12T06:53:36Z","month":"09","quality_controlled":"1","oa":1,"volume":137,"date_published":"2015-09-01T00:00:00Z","type":"journal_article","external_id":{"pmid":["25716227"]},"oa_version":"Submitted Version","article_type":"original","language":[{"iso":"eng"}],"year":"2015","department":[{"_id":"LifeSc"}],"author":[{"last_name":"Schwamb","first_name":"Bettina","full_name":"Schwamb, Bettina"},{"first_name":"Robert","full_name":"Pick, Robert","last_name":"Pick"},{"full_name":"Fernández, Sara","first_name":"Sara","last_name":"Fernández"},{"full_name":"Völp, Kirsten","first_name":"Kirsten","last_name":"Völp"},{"first_name":"Jan","full_name":"Heering, Jan","last_name":"Heering"},{"last_name":"Dötsch","first_name":"Volker","full_name":"Dötsch, Volker"},{"first_name":"Susanne","full_name":"Bösser, Susanne","last_name":"Bösser"},{"full_name":"Jung, Jennifer","first_name":"Jennifer","last_name":"Jung"},{"first_name":"Rasa","full_name":"Beinoravičiute Kellner, Rasa","last_name":"Beinoravičiute Kellner"},{"first_name":"Josephine","full_name":"Wesely, Josephine","last_name":"Wesely"},{"last_name":"Zörnig","first_name":"Inka","full_name":"Zörnig, Inka"},{"first_name":"Matthias","full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt"},{"last_name":"Nowak","full_name":"Nowak, Matthias","id":"30845DAA-F248-11E8-B48F-1D18A9856A87","first_name":"Matthias"},{"last_name":"Penzel","full_name":"Penzel, Roland","first_name":"Roland"},{"first_name":"Kurt","full_name":"Zatloukal, Kurt","last_name":"Zatloukal"},{"full_name":"Joos, Stefan","first_name":"Stefan","last_name":"Joos"},{"full_name":"Rieker, Ralf","first_name":"Ralf","last_name":"Rieker"},{"last_name":"Agaimy","first_name":"Abbas","full_name":"Agaimy, Abbas"},{"full_name":"Söder, Stephan","first_name":"Stephan","last_name":"Söder"},{"full_name":"Reid Lombardo, Kmarie","first_name":"Kmarie","last_name":"Reid Lombardo"},{"last_name":"Kendrick","full_name":"Kendrick, Michael","first_name":"Michael"},{"last_name":"Bardsley","first_name":"Michael","full_name":"Bardsley, Michael"},{"last_name":"Hayashi","full_name":"Hayashi, Yujiro","first_name":"Yujiro"},{"first_name":"David","full_name":"Asuzu, David","last_name":"Asuzu"},{"last_name":"Syed","full_name":"Syed, Sabriya","first_name":"Sabriya"},{"first_name":"Tamás","full_name":"Ördög, Tamás","last_name":"Ördög"},{"last_name":"Zörnig","full_name":"Zörnig, Martin","first_name":"Martin"}],"page":"1318 - 1329","date_created":"2018-12-11T11:54:20Z","publication_status":"published","publist_id":"5253","day":"01","abstract":[{"lang":"eng","text":"The ability to escape apoptosis is a hallmark of cancer-initiating cells and a key factor of resistance to oncolytic therapy. Here, we identify FAM96A as a ubiquitous, evolutionarily conserved apoptosome-activating protein and investigate its potential pro-apoptotic tumor suppressor function in gastrointestinal stromal tumors (GISTs). Interaction between FAM96A and apoptotic peptidase activating factor 1 (APAF1) was identified in yeast two-hybrid screen and further studied by deletion mutants, glutathione-S-transferase pull-down, co-immunoprecipitation and immunofluorescence. Effects of FAM96A overexpression and knock-down on apoptosis sensitivity were examined in cancer cells and zebrafish embryos. Expression of FAM96A in GISTs and histogenetically related cells including interstitial cells of Cajal (ICCs), “fibroblast-like cells” (FLCs) and ICC stem cells (ICC-SCs) was investigated by Northern blotting, reverse transcription—polymerase chain reaction, immunohistochemistry and Western immunoblotting. Tumorigenicity of GIST cells and transformed murine ICC-SCs stably transduced to re-express FAM96A was studied by xeno- and allografting into immunocompromised mice. FAM96A was found to bind APAF1 and to enhance the induction of mitochondrial apoptosis. FAM96A protein or mRNA was dramatically reduced or lost in 106 of 108 GIST samples representing three independent patient cohorts. Whereas ICCs, ICC-SCs and FLCs, the presumed normal counterparts of GIST, were found to robustly express FAM96A protein and mRNA, FAM96A expression was much reduced in tumorigenic ICC-SCs. Re-expression of FAM96A in GIST cells and transformed ICC-SCs increased apoptosis sensitivity and diminished tumorigenicity. Our data suggest FAM96A is a novel pro-apoptotic tumor suppressor that is lost during GIST tumorigenesis."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1848","title":"FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors","pmid":1,"status":"public","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497860/","open_access":"1"}],"intvolume":"       137","citation":{"mla":"Schwamb, Bettina, et al. “FAM96A Is a Novel Pro-Apoptotic Tumor Suppressor in Gastrointestinal Stromal Tumors.” <i>International Journal of Cancer</i>, vol. 137, no. 6, Wiley, 2015, pp. 1318–29, doi:<a href=\"https://doi.org/10.1002/ijc.29498\">10.1002/ijc.29498</a>.","ama":"Schwamb B, Pick R, Fernández S, et al. FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. <i>International Journal of Cancer</i>. 2015;137(6):1318-1329. doi:<a href=\"https://doi.org/10.1002/ijc.29498\">10.1002/ijc.29498</a>","chicago":"Schwamb, Bettina, Robert Pick, Sara Fernández, Kirsten Völp, Jan Heering, Volker Dötsch, Susanne Bösser, et al. “FAM96A Is a Novel Pro-Apoptotic Tumor Suppressor in Gastrointestinal Stromal Tumors.” <i>International Journal of Cancer</i>. Wiley, 2015. <a href=\"https://doi.org/10.1002/ijc.29498\">https://doi.org/10.1002/ijc.29498</a>.","apa":"Schwamb, B., Pick, R., Fernández, S., Völp, K., Heering, J., Dötsch, V., … Zörnig, M. (2015). FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. <i>International Journal of Cancer</i>. Wiley. <a href=\"https://doi.org/10.1002/ijc.29498\">https://doi.org/10.1002/ijc.29498</a>","ista":"Schwamb B, Pick R, Fernández S, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoravičiute Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker R, Agaimy A, Söder S, Reid Lombardo K, Kendrick M, Bardsley M, Hayashi Y, Asuzu D, Syed S, Ördög T, Zörnig M. 2015. FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. International Journal of Cancer. 137(6), 1318–1329.","short":"B. Schwamb, R. Pick, S. Fernández, K. Völp, J. Heering, V. Dötsch, S. Bösser, J. Jung, R. Beinoravičiute Kellner, J. Wesely, I. Zörnig, M. Hammerschmidt, M. Nowak, R. Penzel, K. Zatloukal, S. Joos, R. Rieker, A. Agaimy, S. Söder, K. Reid Lombardo, M. Kendrick, M. Bardsley, Y. Hayashi, D. Asuzu, S. Syed, T. Ördög, M. Zörnig, International Journal of Cancer 137 (2015) 1318–1329.","ieee":"B. Schwamb <i>et al.</i>, “FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors,” <i>International Journal of Cancer</i>, vol. 137, no. 6. Wiley, pp. 1318–1329, 2015."},"scopus_import":1,"issue":"6"},{"issue":"729","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"scopus_import":"1","status":"public","ec_funded":1,"intvolume":"       516","citation":{"chicago":"Chen, Xu, Laurie Grandont, Hongjiang Li, Robert Hauschild, Sébastien Paque, Anas Abuzeineh, Hana Rakusova, Eva Benková, Catherine Perrot Rechenmann, and Jiří Friml. “Inhibition of Cell Expansion by Rapid ABP1-Mediated Auxin Effect on Microtubules.” <i>Nature</i>. Nature Publishing Group, 2014. <a href=\"https://doi.org/10.1038/nature13889\">https://doi.org/10.1038/nature13889</a>.","mla":"Chen, Xu, et al. “Inhibition of Cell Expansion by Rapid ABP1-Mediated Auxin Effect on Microtubules.” <i>Nature</i>, vol. 516, no. 729, Nature Publishing Group, 2014, pp. 90–93, doi:<a href=\"https://doi.org/10.1038/nature13889\">10.1038/nature13889</a>.","ama":"Chen X, Grandont L, Li H, et al. Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules. <i>Nature</i>. 2014;516(729):90-93. doi:<a href=\"https://doi.org/10.1038/nature13889\">10.1038/nature13889</a>","ieee":"X. Chen <i>et al.</i>, “Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules,” <i>Nature</i>, vol. 516, no. 729. Nature Publishing Group, pp. 90–93, 2014.","short":"X. Chen, L. Grandont, H. Li, R. Hauschild, S. Paque, A. Abuzeineh, H. Rakusova, E. Benková, C. Perrot Rechenmann, J. Friml, Nature 516 (2014) 90–93.","apa":"Chen, X., Grandont, L., Li, H., Hauschild, R., Paque, S., Abuzeineh, A., … Friml, J. (2014). Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature13889\">https://doi.org/10.1038/nature13889</a>","ista":"Chen X, Grandont L, Li H, Hauschild R, Paque S, Abuzeineh A, Rakusova H, Benková E, Perrot Rechenmann C, Friml J. 2014. Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules. Nature. 516(729), 90–93."},"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257754/","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"The prominent and evolutionarily ancient role of the plant hormone auxin is the regulation of cell expansion. Cell expansion requires ordered arrangement of the cytoskeleton but molecular mechanisms underlying its regulation by signalling molecules including auxin are unknown. Here we show in the model plant Arabidopsis thaliana that in elongating cells exogenous application of auxin or redistribution of endogenous auxin induces very rapid microtubule re-orientation from transverse to longitudinal, coherent with the inhibition of cell expansion. This fast auxin effect requires auxin binding protein 1 (ABP1) and involves a contribution of downstream signalling components such as ROP6 GTPase, ROP-interactive protein RIC1 and the microtubule-severing protein katanin. These components are required for rapid auxin-and ABP1-mediated re-orientation of microtubules to regulate cell elongation in roots and dark-grown hypocotyls as well as asymmetric growth during gravitropic responses.","lang":"eng"}],"title":"Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules","_id":"1862","pmid":1,"acknowledgement":"We thank R. Dixit for performing complementary experiments, D. W. Ehrhardt and T. Hashimoto for providing the seeds of TUB6–RFP and EB1b–GFP respectively, E. Zazimalova, J. Petrasek and M. Fendrych for discussing the manuscript and J. Leung for text optimization. This work was supported by the European Research Council (project ERC-2011-StG-20101109-PSDP, to J.F.), ANR blanc AuxiWall project (ANR-11-BSV5-0007, to C.P.-R. and L.G.) and the Agency for Innovation by Science and Technology (IWT) (to H.R.). This work benefited from the facilities and expertise of the Imagif Cell Biology platform (http://www.imagif.cnrs.fr), which is supported by the Conseil Général de l’Essonne.","author":[{"last_name":"Chen","full_name":"Chen, Xu","first_name":"Xu","id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Grandont","first_name":"Laurie","full_name":"Grandont, Laurie"},{"orcid":"0000-0001-5039-9660","last_name":"Li","first_name":"Hongjiang","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Hongjiang"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","last_name":"Hauschild"},{"first_name":"Sébastien","full_name":"Paque, Sébastien","last_name":"Paque"},{"full_name":"Abuzeineh, Anas","first_name":"Anas","last_name":"Abuzeineh"},{"last_name":"Rakusova","first_name":"Hana","id":"4CAAA450-78D2-11EA-8E57-B40A396E08BA","full_name":"Rakusova, Hana"},{"last_name":"Benková","orcid":"0000-0002-8510-9739","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva"},{"first_name":"Catherine","full_name":"Perrot Rechenmann, Catherine","last_name":"Perrot Rechenmann"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"page":"90 - 93","date_created":"2018-12-11T11:54:25Z","day":"04","publist_id":"5237","publication_status":"published","year":"2014","language":[{"iso":"eng"}],"department":[{"_id":"JiFr"},{"_id":"Bio"},{"_id":"EvBe"}],"type":"journal_article","date_published":"2014-12-04T00:00:00Z","project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","grant_number":"282300","name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7"}],"volume":516,"article_type":"original","external_id":{"pmid":["25409144"]},"oa_version":"Submitted Version","article_processing_charge":"No","doi":"10.1038/nature13889","publisher":"Nature Publishing Group","date_updated":"2025-05-07T11:12:31Z","publication":"Nature","month":"12","quality_controlled":"1","oa":1},{"year":"2014","language":[{"iso":"eng"}],"ddc":["000"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"page":"385 - 395","pubrep_id":"442","author":[{"last_name":"Körner","first_name":"Christof","full_name":"Körner, Christof"},{"last_name":"Braunstein","first_name":"Verena","full_name":"Braunstein, Verena"},{"first_name":"Matthias","full_name":"Stangl, Matthias","last_name":"Stangl"},{"orcid":"0000-0002-5621-8100","last_name":"Schlögl","full_name":"Schlögl, Alois","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Neuper, Christa","first_name":"Christa","last_name":"Neuper"},{"last_name":"Ischebeck","first_name":"Anja","full_name":"Ischebeck, Anja"}],"publication_status":"published","publist_id":"5205","day":"11","date_created":"2018-12-11T11:54:34Z","publication":"Psychophysiology","date_updated":"2021-01-12T06:53:52Z","publisher":"Wiley-Blackwell","doi":"10.1111/psyp.12062","oa":1,"file":[{"date_created":"2018-12-12T10:16:44Z","file_id":"5233","content_type":"application/pdf","relation":"main_file","creator":"system","checksum":"4255b6185e774acce1d99f8e195c564d","access_level":"open_access","file_name":"IST-2016-442-v1+1_K-rner_et_al-2014-Psychophysiology.pdf","file_size":543243,"date_updated":"2020-07-14T12:45:20Z"}],"month":"02","volume":51,"type":"journal_article","date_published":"2014-02-11T00:00:00Z","oa_version":"Published Version","scopus_import":1,"file_date_updated":"2020-07-14T12:45:20Z","issue":"4","_id":"1890","title":"Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection","abstract":[{"lang":"eng","text":"To search for a target in a complex environment is an everyday behavior that ends with finding the target. When we search for two identical targets, however, we must continue the search after finding the first target and memorize its location. We used fixation-related potentials to investigate the neural correlates of different stages of the search, that is, before and after finding the first target. Having found the first target influenced subsequent distractor processing. Compared to distractor fixations before the first target fixation, a negative shift was observed for three subsequent distractor fixations. These results suggest that processing a target in continued search modulates the brain's response, either transiently by reflecting temporary working memory processes or permanently by reflecting working memory retention."}],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Funded by Austrian Science Fund (FWF) Grant Number: P 22189-B18; European Union within the 6th Framework Programme Grant Number: 517590; State government of Styria Grant Number: PN 4055","status":"public","has_accepted_license":"1","intvolume":"        51","citation":{"ieee":"C. Körner, V. Braunstein, M. Stangl, A. Schlögl, C. Neuper, and A. Ischebeck, “Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection,” <i>Psychophysiology</i>, vol. 51, no. 4. Wiley-Blackwell, pp. 385–395, 2014.","short":"C. Körner, V. Braunstein, M. Stangl, A. Schlögl, C. Neuper, A. Ischebeck, Psychophysiology 51 (2014) 385–395.","apa":"Körner, C., Braunstein, V., Stangl, M., Schlögl, A., Neuper, C., &#38; Ischebeck, A. (2014). Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection. <i>Psychophysiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/psyp.12062\">https://doi.org/10.1111/psyp.12062</a>","ista":"Körner C, Braunstein V, Stangl M, Schlögl A, Neuper C, Ischebeck A. 2014. Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection. Psychophysiology. 51(4), 385–395.","chicago":"Körner, Christof, Verena Braunstein, Matthias Stangl, Alois Schlögl, Christa Neuper, and Anja Ischebeck. “Sequential Effects in Continued Visual Search: Using Fixation-Related Potentials to Compare Distractor Processing before and after Target Detection.” <i>Psychophysiology</i>. Wiley-Blackwell, 2014. <a href=\"https://doi.org/10.1111/psyp.12062\">https://doi.org/10.1111/psyp.12062</a>.","mla":"Körner, Christof, et al. “Sequential Effects in Continued Visual Search: Using Fixation-Related Potentials to Compare Distractor Processing before and after Target Detection.” <i>Psychophysiology</i>, vol. 51, no. 4, Wiley-Blackwell, 2014, pp. 385–95, doi:<a href=\"https://doi.org/10.1111/psyp.12062\">10.1111/psyp.12062</a>.","ama":"Körner C, Braunstein V, Stangl M, Schlögl A, Neuper C, Ischebeck A. Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection. <i>Psychophysiology</i>. 2014;51(4):385-395. doi:<a href=\"https://doi.org/10.1111/psyp.12062\">10.1111/psyp.12062</a>"}},{"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211437/","open_access":"1"}],"intvolume":"       281","citation":{"mla":"Ocana, Sabine, et al. “Y-Linked Mendelian Inheritance of Giant and Dwarf Male Morphs in Shell-Brooding Cichlids.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 281, no. 1794, 20140253, The Royal Society, 2014, doi:<a href=\"https://doi.org/10.1098/rspb.2014.0253\">10.1098/rspb.2014.0253</a>.","ama":"Ocana S, Meidl P, Bonfils D, Taborsky M. Y-linked Mendelian inheritance of giant and dwarf male morphs in shell-brooding cichlids. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2014;281(1794). doi:<a href=\"https://doi.org/10.1098/rspb.2014.0253\">10.1098/rspb.2014.0253</a>","chicago":"Ocana, Sabine, Patrick Meidl, Danielle Bonfils, and Michael Taborsky. “Y-Linked Mendelian Inheritance of Giant and Dwarf Male Morphs in Shell-Brooding Cichlids.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. The Royal Society, 2014. <a href=\"https://doi.org/10.1098/rspb.2014.0253\">https://doi.org/10.1098/rspb.2014.0253</a>.","apa":"Ocana, S., Meidl, P., Bonfils, D., &#38; Taborsky, M. (2014). Y-linked Mendelian inheritance of giant and dwarf male morphs in shell-brooding cichlids. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rspb.2014.0253\">https://doi.org/10.1098/rspb.2014.0253</a>","ista":"Ocana S, Meidl P, Bonfils D, Taborsky M. 2014. Y-linked Mendelian inheritance of giant and dwarf male morphs in shell-brooding cichlids. Proceedings of the Royal Society of London Series B Biological Sciences. 281(1794), 20140253.","short":"S. Ocana, P. Meidl, D. Bonfils, M. Taborsky, Proceedings of the Royal Society of London Series B Biological Sciences 281 (2014).","ieee":"S. Ocana, P. Meidl, D. Bonfils, and M. Taborsky, “Y-linked Mendelian inheritance of giant and dwarf male morphs in shell-brooding cichlids,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 281, no. 1794. The Royal Society, 2014."},"status":"public","pmid":1,"acknowledgement":"This research was supported by grants of the Swiss National Science Foundation to M.T.\r\nWe thank Tetsu Sato for providing field samples, Olivier Goffinet for field assistance, Dolores Schütz for vital help in the field and with the manuscript, David Lank, Barbara Taborsky, Suzanne Alonzo and two anonymous referees for comments on earlier manuscript versions, and the Fisheries Department, Ministry of Agriculture and Livestock of Zambia, for permission and support.","abstract":[{"lang":"eng","text":"Behavioural variation among conspecifics is typically contingent on individual state or environmental conditions. Sex-specific genetic polymorphisms are enigmatic because they lack conditionality, and genes causing adaptive trait variation in one sex may reduce Darwinian fitness in the other. One way to avoid such genetic antagonism is to control sex-specific traits by inheritance via sex chromosomes. Here, controlled laboratory crossings suggest that in snail-brooding cichlid fish a single locus, two-allele polymorphism located on a sex-linked chromosome of heterogametic males generates an extreme reproductive dimorphism. Both natural and sexual selection are responsible for exceptionally large body size of bourgeois males, creating a niche for a miniature male phenotype to evolve. This extreme intrasexual dimorphism results from selection on opposite size thresholds caused by a single ecological factor, empty snail shells used as breeding substrate. Paternity analyses reveal that in the field parasitic dwarf males sire the majority of offspring in direct sperm competition with large nest owners exceeding their size more than 40 times. Apparently, use of empty snail shells as breeding substrate and single locus sex-linked inheritance of growth are the major ecological and genetic mechanisms responsible for the extreme intrasexual diversity observed in Lamprologus callipterus."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1892","title":"Y-linked Mendelian inheritance of giant and dwarf male morphs in shell-brooding cichlids","issue":"1794","scopus_import":"1","article_type":"original","oa_version":"Submitted Version","external_id":{"pmid":["25232141"]},"volume":281,"date_published":"2014-11-07T00:00:00Z","type":"journal_article","month":"11","article_number":"20140253","quality_controlled":"1","oa":1,"article_processing_charge":"No","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","publisher":"The Royal Society","date_updated":"2022-06-07T09:12:32Z","doi":"10.1098/rspb.2014.0253","date_created":"2018-12-11T11:54:34Z","publist_id":"5203","publication_status":"published","day":"07","author":[{"last_name":"Ocana","full_name":"Ocana, Sabine","first_name":"Sabine"},{"full_name":"Meidl, Patrick","first_name":"Patrick","id":"4709BCE6-F248-11E8-B48F-1D18A9856A87","last_name":"Meidl"},{"last_name":"Bonfils","full_name":"Bonfils, Danielle","first_name":"Danielle"},{"last_name":"Taborsky","first_name":"Michael","full_name":"Taborsky, Michael"}],"department":[{"_id":"CampIT"}],"language":[{"iso":"eng"}],"year":"2014"},{"volume":159,"date_published":"2014-11-06T00:00:00Z","type":"journal_article","project":[{"name":"Molecular Mechanisms of Cerebral Cortex Development","call_identifier":"FP7","grant_number":"618444","_id":"25D61E48-B435-11E9-9278-68D0E5697425"},{"_id":"25D7962E-B435-11E9-9278-68D0E5697425","grant_number":"RGP0053/2014","name":"Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal Level"}],"oa_version":"Published Version","publication":"Cell","date_updated":"2021-01-12T06:54:47Z","publisher":"Cell Press","doi":"10.1016/j.cell.2014.10.027","file":[{"access_level":"open_access","file_name":"IST-2016-423-v1+1_1-s2.0-S0092867414013154-main.pdf","checksum":"6c5de8329bb2ffa71cba9fda750f14ce","date_updated":"2020-07-14T12:45:25Z","file_size":4435787,"content_type":"application/pdf","file_id":"4709","date_created":"2018-12-12T10:08:47Z","relation":"main_file","creator":"system"}],"quality_controlled":"1","oa":1,"month":"11","page":"775 - 788","pubrep_id":"423","author":[{"last_name":"Gao","first_name":"Peng","full_name":"Gao, Peng"},{"full_name":"Postiglione, Maria P","id":"2C67902A-F248-11E8-B48F-1D18A9856A87","first_name":"Maria P","last_name":"Postiglione"},{"last_name":"Krieger","first_name":"Teresa","full_name":"Krieger, Teresa"},{"first_name":"Luisirene","full_name":"Hernandez, Luisirene","last_name":"Hernandez"},{"last_name":"Wang","full_name":"Wang, Chao","first_name":"Chao"},{"last_name":"Han","full_name":"Han, Zhi","first_name":"Zhi"},{"id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","first_name":"Carmen","full_name":"Streicher, Carmen","last_name":"Streicher"},{"full_name":"Papusheva, Ekaterina","id":"41DB591E-F248-11E8-B48F-1D18A9856A87","first_name":"Ekaterina","last_name":"Papusheva"},{"first_name":"Ryan","full_name":"Insolera, Ryan","last_name":"Insolera"},{"full_name":"Chugh, Kritika","first_name":"Kritika","last_name":"Chugh"},{"last_name":"Kodish","full_name":"Kodish, Oren","first_name":"Oren"},{"first_name":"Kun","full_name":"Huang, Kun","last_name":"Huang"},{"last_name":"Simons","full_name":"Simons, Benjamin","first_name":"Benjamin"},{"last_name":"Luo","full_name":"Luo, Liqun","first_name":"Liqun"},{"orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon"},{"full_name":"Shi, Song","first_name":"Song","last_name":"Shi"}],"publist_id":"5050","publication_status":"published","day":"06","date_created":"2018-12-11T11:55:16Z","language":[{"iso":"eng"}],"ddc":["570"],"year":"2014","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"SiHi"},{"_id":"Bio"}],"ec_funded":1,"status":"public","has_accepted_license":"1","citation":{"mla":"Gao, Peng, et al. “Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex.” <i>Cell</i>, vol. 159, no. 4, Cell Press, 2014, pp. 775–88, doi:<a href=\"https://doi.org/10.1016/j.cell.2014.10.027\">10.1016/j.cell.2014.10.027</a>.","ama":"Gao P, Postiglione MP, Krieger T, et al. Deterministic progenitor behavior and unitary production of neurons in the neocortex. <i>Cell</i>. 2014;159(4):775-788. doi:<a href=\"https://doi.org/10.1016/j.cell.2014.10.027\">10.1016/j.cell.2014.10.027</a>","chicago":"Gao, Peng, Maria P Postiglione, Teresa Krieger, Luisirene Hernandez, Chao Wang, Zhi Han, Carmen Streicher, et al. “Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex.” <i>Cell</i>. Cell Press, 2014. <a href=\"https://doi.org/10.1016/j.cell.2014.10.027\">https://doi.org/10.1016/j.cell.2014.10.027</a>.","apa":"Gao, P., Postiglione, M. P., Krieger, T., Hernandez, L., Wang, C., Han, Z., … Shi, S. (2014). Deterministic progenitor behavior and unitary production of neurons in the neocortex. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cell.2014.10.027\">https://doi.org/10.1016/j.cell.2014.10.027</a>","ista":"Gao P, Postiglione MP, Krieger T, Hernandez L, Wang C, Han Z, Streicher C, Papusheva E, Insolera R, Chugh K, Kodish O, Huang K, Simons B, Luo L, Hippenmeyer S, Shi S. 2014. Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell. 159(4), 775–788.","short":"P. Gao, M.P. Postiglione, T. Krieger, L. Hernandez, C. Wang, Z. Han, C. Streicher, E. Papusheva, R. Insolera, K. Chugh, O. Kodish, K. Huang, B. Simons, L. Luo, S. Hippenmeyer, S. Shi, Cell 159 (2014) 775–788.","ieee":"P. Gao <i>et al.</i>, “Deterministic progenitor behavior and unitary production of neurons in the neocortex,” <i>Cell</i>, vol. 159, no. 4. Cell Press, pp. 775–788, 2014."},"intvolume":"       159","_id":"2022","title":"Deterministic progenitor behavior and unitary production of neurons in the neocortex","abstract":[{"lang":"eng","text":"Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical neurons. To gain insight into the patterns of RGP division and neuron production, we quantitatively analyzed excitatory neuron genesis in the mouse neocortex using Mosaic Analysis with Double Markers, which provides single-cell resolution of progenitor division patterns and potential in vivo. We found that RGPs progress through a coherent program in which their proliferative potential diminishes in a predictable manner. Upon entry into the neurogenic phase, individual RGPs produce ∼8–9 neurons distributed in both deep and superficial layers, indicating a unitary output in neuronal production. Removal of OTX1, a transcription factor transiently expressed in RGPs, results in both deep- and superficial-layer neuron loss and a reduction in neuronal unit size. Moreover, ∼1/6 of neurogenic RGPs proceed to produce glia. These results suggest that progenitor behavior and histogenesis in the mammalian neocortex conform to a remarkably orderly and deterministic program."}],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","issue":"4","scopus_import":1,"file_date_updated":"2020-07-14T12:45:25Z"},{"date_created":"2018-12-12T11:39:14Z","pubrep_id":"254","author":[{"id":"3252EDC2-F248-11E8-B48F-1D18A9856A87","first_name":"Jana","full_name":"Porsche, Jana","last_name":"Porsche"}],"file_date_updated":"2020-07-14T12:46:50Z","department":[{"_id":"E-Lib"}],"ddc":["020"],"language":[{"iso":"eng"}],"year":"2014","oa_version":"None","has_accepted_license":"1","citation":{"mla":"Porsche, Jana. <i>Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland</i>. none, 2014.","ama":"Porsche J. <i>Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland</i>. none; 2014.","chicago":"Porsche, Jana. <i>Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland</i>. none, 2014.","apa":"Porsche, J. (2014). <i>Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland</i>. none.","ista":"Porsche J. 2014. Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland, none,p.","short":"J. Porsche, Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland, none, 2014.","ieee":"J. Porsche, <i>Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland</i>. none, 2014."},"date_published":"2014-01-01T00:00:00Z","type":"report","status":"public","oa":1,"file":[{"relation":"main_file","creator":"system","date_created":"2018-12-12T11:53:40Z","file_id":"5501","content_type":"application/pdf","file_size":648585,"date_updated":"2020-07-14T12:46:50Z","checksum":"3954896648ce8afa8f7c4425e71cff08","access_level":"open_access","file_name":"IST-2014-254-v1+1_Dublin_Day_3.pdf"},{"date_updated":"2020-07-14T12:46:50Z","file_size":221339,"file_name":"IST-2014-254-v1+2_Dublin_Day_1.pdf","access_level":"open_access","checksum":"9a0d42b0b832dfe7e4b22fb6816bcbba","relation":"main_file","creator":"system","content_type":"application/pdf","file_id":"5502","date_created":"2018-12-12T11:53:41Z"},{"checksum":"498b8d629fb1bd17bff1dc43700a93e6","access_level":"open_access","file_name":"IST-2014-254-v1+3_Dublin_Day_2.pdf","file_size":187778,"date_updated":"2020-07-14T12:46:50Z","file_id":"5503","date_created":"2018-12-12T11:53:42Z","content_type":"application/pdf","creator":"system","relation":"main_file"}],"abstract":[{"lang":"eng","text":"Notes from the Third Plenary for the Research Data Alliance in Dublin, Ireland on March 26 to 28, 2014 with focus on starting an institutional research data repository."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"5422","publisher":"none","title":"Notes from Research Data Alliance Plenary Meeting in Dublin, Ireland","date_updated":"2020-07-14T23:04:56Z"},{"department":[{"_id":"CampIT"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"ddc":["576"],"year":"2014","publication_status":"published","publist_id":"7352","day":"23","date_created":"2018-12-11T11:46:38Z","pubrep_id":"954","author":[{"first_name":"Arno","full_name":"Cimadom, Arno","last_name":"Cimadom"},{"last_name":"Ulloa","full_name":"Ulloa, Angel","first_name":"Angel"},{"last_name":"Meidl","first_name":"Patrick","id":"4709BCE6-F248-11E8-B48F-1D18A9856A87","full_name":"Meidl, Patrick"},{"last_name":"Zöttl","full_name":"Zöttl, Markus","first_name":"Markus"},{"first_name":"Elisabet","full_name":"Zöttl, Elisabet","last_name":"Zöttl"},{"last_name":"Fessl","full_name":"Fessl, Birgit","first_name":"Birgit"},{"last_name":"Nemeth","first_name":"Erwin","full_name":"Nemeth, Erwin"},{"last_name":"Dvorak","first_name":"Michael","full_name":"Dvorak, Michael"},{"last_name":"Cunninghame","first_name":"Francesca","full_name":"Cunninghame, Francesca"},{"last_name":"Tebbich","full_name":"Tebbich, Sabine","first_name":"Sabine"}],"article_number":"0107518","file":[{"file_size":489387,"date_updated":"2020-07-14T12:46:34Z","checksum":"b24e7518ccd41effed0d7d9e2498f67f","file_name":"IST-2018-954-v1+1_2014_Meidl_Invasive_parasites.PDF","access_level":"open_access","creator":"system","relation":"main_file","file_id":"5103","date_created":"2018-12-12T10:14:48Z","content_type":"application/pdf"}],"oa":1,"quality_controlled":"1","month":"09","publication":"PLoS One","date_updated":"2021-01-12T08:00:48Z","publisher":"Public Library of Science","doi":"10.1371/journal.pone.0107518","oa_version":"Published Version","volume":9,"date_published":"2014-09-23T00:00:00Z","type":"journal_article","file_date_updated":"2020-07-14T12:46:34Z","scopus_import":1,"issue":"9","acknowledgement":"The study was funded by the University of Vienna (Focus of Excellence grant), the Galápagos Conservation Trust, and the Ethologische Gesellschaft e.V.","_id":"468","title":"Invasive parasites habitat change and heavy rainfall reduce breeding success in Darwin's finches","abstract":[{"text":"Invasive alien parasites and pathogens are a growing threat to biodiversity worldwide, which can contribute to the extinction of endemic species. On the Galápagos Islands, the invasive parasitic fly Philornis downsi poses a major threat to the endemic avifauna. Here, we investigated the influence of this parasite on the breeding success of two Darwin's finch species, the warbler finch (Certhidea olivacea) and the sympatric small tree finch (Camarhynchus parvulus), on Santa Cruz Island in 2010 and 2012. While the population of the small tree finch appeared to be stable, the warbler finch has experienced a dramatic decline in population size on Santa Cruz Island since 1997. We aimed to identify whether warbler finches are particularly vulnerable during different stages of the breeding cycle. Contrary to our prediction, breeding success was lower in the small tree finch than in the warbler finch. In both species P. downsi had a strong negative impact on breeding success and our data suggest that heavy rain events also lowered the fledging success. On the one hand parents might be less efficient in compensating their chicks' energy loss due to parasitism as they might be less efficient in foraging on days of heavy rain. On the other hand, intense rainfalls might lead to increased humidity and more rapid cooling of the nests. In the case of the warbler finch we found that the control of invasive plant species with herbicides had a significant additive negative impact on the breeding success. It is very likely that the availability of insects (i.e. food abundance) is lower in such controlled areas, as herbicide usage led to the removal of the entire understory. Predation seems to be a minor factor in brood loss.","lang":"eng"}],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","intvolume":"         9","citation":{"ieee":"A. Cimadom <i>et al.</i>, “Invasive parasites habitat change and heavy rainfall reduce breeding success in Darwin’s finches,” <i>PLoS One</i>, vol. 9, no. 9. Public Library of Science, 2014.","short":"A. Cimadom, A. Ulloa, P. Meidl, M. Zöttl, E. Zöttl, B. Fessl, E. Nemeth, M. Dvorak, F. Cunninghame, S. Tebbich, PLoS One 9 (2014).","apa":"Cimadom, A., Ulloa, A., Meidl, P., Zöttl, M., Zöttl, E., Fessl, B., … Tebbich, S. (2014). Invasive parasites habitat change and heavy rainfall reduce breeding success in Darwin’s finches. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0107518\">https://doi.org/10.1371/journal.pone.0107518</a>","ista":"Cimadom A, Ulloa A, Meidl P, Zöttl M, Zöttl E, Fessl B, Nemeth E, Dvorak M, Cunninghame F, Tebbich S. 2014. Invasive parasites habitat change and heavy rainfall reduce breeding success in Darwin’s finches. PLoS One. 9(9), 0107518.","chicago":"Cimadom, Arno, Angel Ulloa, Patrick Meidl, Markus Zöttl, Elisabet Zöttl, Birgit Fessl, Erwin Nemeth, Michael Dvorak, Francesca Cunninghame, and Sabine Tebbich. “Invasive Parasites Habitat Change and Heavy Rainfall Reduce Breeding Success in Darwin’s Finches.” <i>PLoS One</i>. Public Library of Science, 2014. <a href=\"https://doi.org/10.1371/journal.pone.0107518\">https://doi.org/10.1371/journal.pone.0107518</a>.","mla":"Cimadom, Arno, et al. “Invasive Parasites Habitat Change and Heavy Rainfall Reduce Breeding Success in Darwin’s Finches.” <i>PLoS One</i>, vol. 9, no. 9, 0107518, Public Library of Science, 2014, doi:<a href=\"https://doi.org/10.1371/journal.pone.0107518\">10.1371/journal.pone.0107518</a>.","ama":"Cimadom A, Ulloa A, Meidl P, et al. Invasive parasites habitat change and heavy rainfall reduce breeding success in Darwin’s finches. <i>PLoS One</i>. 2014;9(9). doi:<a href=\"https://doi.org/10.1371/journal.pone.0107518\">10.1371/journal.pone.0107518</a>"},"status":"public"},{"status":"public","intvolume":"         8","citation":{"mla":"Guzmán, José, et al. “Stimfit: Quantifying Electrophysiological Data with Python.” <i>Frontiers in Neuroinformatics</i>, vol. 8, no. FEB, 16, Frontiers Research Foundation, 2014, doi:<a href=\"https://doi.org/10.3389/fninf.2014.00016\">10.3389/fninf.2014.00016</a>.","ama":"Guzmán J, Schlögl A, Schmidt Hieber C. Stimfit: Quantifying electrophysiological data with Python. <i>Frontiers in Neuroinformatics</i>. 2014;8(FEB). doi:<a href=\"https://doi.org/10.3389/fninf.2014.00016\">10.3389/fninf.2014.00016</a>","chicago":"Guzmán, José, Alois Schlögl, and Christoph Schmidt Hieber. “Stimfit: Quantifying Electrophysiological Data with Python.” <i>Frontiers in Neuroinformatics</i>. Frontiers Research Foundation, 2014. <a href=\"https://doi.org/10.3389/fninf.2014.00016\">https://doi.org/10.3389/fninf.2014.00016</a>.","apa":"Guzmán, J., Schlögl, A., &#38; Schmidt Hieber, C. (2014). Stimfit: Quantifying electrophysiological data with Python. <i>Frontiers in Neuroinformatics</i>. Frontiers Research Foundation. <a href=\"https://doi.org/10.3389/fninf.2014.00016\">https://doi.org/10.3389/fninf.2014.00016</a>","ista":"Guzmán J, Schlögl A, Schmidt Hieber C. 2014. Stimfit: Quantifying electrophysiological data with Python. Frontiers in Neuroinformatics. 8(FEB), 16.","ieee":"J. Guzmán, A. Schlögl, and C. Schmidt Hieber, “Stimfit: Quantifying electrophysiological data with Python,” <i>Frontiers in Neuroinformatics</i>, vol. 8, no. FEB. Frontiers Research Foundation, 2014.","short":"J. Guzmán, A. Schlögl, C. Schmidt Hieber, Frontiers in Neuroinformatics 8 (2014)."},"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Intracellular electrophysiological recordings provide crucial insights into elementary neuronal signals such as action potentials and synaptic currents. Analyzing and interpreting these signals is essential for a quantitative understanding of neuronal information processing, and requires both fast data visualization and ready access to complex analysis routines. To achieve this goal, we have developed Stimfit, a free software package for cellular neurophysiology with a Python scripting interface and a built-in Python shell. The program supports most standard file formats for cellular neurophysiology and other biomedical signals through the Biosig library. To quantify and interpret the activity of single neurons and communication between neurons, the program includes algorithms to characterize the kinetics of presynaptic action potentials and postsynaptic currents, estimate latencies between pre- and postsynaptic events, and detect spontaneously occurring events. We validate and benchmark these algorithms, give estimation errors, and provide sample use cases, showing that Stimfit represents an efficient, accessible and extensible way to accurately analyze and interpret neuronal signals."}],"title":"Stimfit: Quantifying electrophysiological data with Python","_id":"2230","issue":"FEB","publication_identifier":{"issn":["16625196"]},"scopus_import":1,"file_date_updated":"2020-07-14T12:45:34Z","type":"journal_article","date_published":"2014-02-21T00:00:00Z","volume":8,"oa_version":"Published Version","date_updated":"2021-01-12T06:56:09Z","doi":"10.3389/fninf.2014.00016","publisher":"Frontiers Research Foundation","publication":"Frontiers in Neuroinformatics","month":"02","quality_controlled":"1","oa":1,"file":[{"content_type":"application/pdf","date_created":"2018-12-12T10:12:17Z","file_id":"4935","relation":"main_file","creator":"system","file_name":"IST-2016-425-v1+1_fninf-08-00016.pdf","access_level":"open_access","checksum":"eeca00bba7232ff7d27db83321f6ea30","date_updated":"2020-07-14T12:45:34Z","file_size":2883372}],"article_number":"16","author":[{"full_name":"Guzmán, José","id":"30CC5506-F248-11E8-B48F-1D18A9856A87","first_name":"José","last_name":"Guzmán"},{"full_name":"Schlögl, Alois","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5621-8100","last_name":"Schlögl"},{"last_name":"Schmidt Hieber","full_name":"Schmidt Hieber, Christoph","first_name":"Christoph"}],"pubrep_id":"425","date_created":"2018-12-11T11:56:27Z","day":"21","publist_id":"4731","publication_status":"published","year":"2014","language":[{"iso":"eng"}],"ddc":["570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"ScienComp"},{"_id":"PeJo"}]},{"pubrep_id":"113","author":[{"id":"3252EDC2-F248-11E8-B48F-1D18A9856A87","first_name":"Jana","full_name":"Porsche, Jana","last_name":"Porsche"}],"date_created":"2018-12-12T11:39:07Z","publication_status":"published","day":"20","language":[{"iso":"eng"}],"year":"2013","ddc":["020"],"department":[{"_id":"E-Lib"}],"file_date_updated":"2020-07-14T12:46:45Z","type":"report","date_published":"2013-03-20T00:00:00Z","status":"public","oa_version":"Published Version","has_accepted_license":"1","citation":{"chicago":"Porsche, Jana. <i>Initiatives and Projects Related to RD</i>. 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(Open) Linked Data in Bibliotheken, De Gruyter,p."},"intvolume":"        50","has_accepted_license":"1","status":"public","file_date_updated":"2020-07-14T12:45:38Z","publication_identifier":{"isbn":[" 978-3-11-027634-3"],"eisbn":["9-783-1102-7873-6"],"issn":["2191-3587"]}},{"oa_version":"Published Version","type":"journal_article","date_published":"2013-06-13T00:00:00Z","volume":1,"month":"06","quality_controlled":"1","oa":1,"file":[{"file_size":130026,"date_updated":"2020-07-14T12:45:40Z","checksum":"0751ec74b695567e0cdf02aaf9c26829","access_level":"open_access","file_name":"IST-2015-398-v1+1_Genome_Announc.-2013-Redondo-.pdf","creator":"system","relation":"main_file","file_id":"5291","date_created":"2018-12-12T10:17:36Z","content_type":"application/pdf"}],"date_updated":"2021-01-12T06:57:19Z","publisher":"American Society for Microbiology","doi":"10.1128/genomeA.00216-13","publication":"Genome Announcements","date_created":"2018-12-11T11:57:30Z","day":"13","publist_id":"4516","publication_status":"published","author":[{"full_name":"Fernandes Redondo, Rodrigo A","id":"409D5C96-F248-11E8-B48F-1D18A9856A87","first_name":"Rodrigo A","orcid":"0000-0002-5837-2793","last_name":"Fernandes Redondo"},{"full_name":"Kupczok, Anne","first_name":"Anne","id":"2BB22BC2-F248-11E8-B48F-1D18A9856A87","last_name":"Kupczok"},{"full_name":"Stift, Gertraud","first_name":"Gertraud","id":"2DB195CA-F248-11E8-B48F-1D18A9856A87","last_name":"Stift"},{"first_name":"Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","full_name":"Bollback, Jonathan P","last_name":"Bollback","orcid":"0000-0002-4624-4612"}],"pubrep_id":"398","department":[{"_id":"JoBo"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"year":"2013","ddc":["576"],"intvolume":"         1","citation":{"mla":"Fernandes Redondo, Rodrigo A., et al. “Complete Genome Sequence of the Novel Phage MG-B1 Infecting Bacillus Weihenstephanensis.” <i>Genome Announcements</i>, vol. 1, no. 3, American Society for Microbiology, 2013, doi:<a href=\"https://doi.org/10.1128/genomeA.00216-13\">10.1128/genomeA.00216-13</a>.","ama":"Fernandes Redondo RA, Kupczok A, Stift G, Bollback JP. Complete genome sequence of the novel phage MG-B1 infecting bacillus weihenstephanensis. <i>Genome Announcements</i>. 2013;1(3). doi:<a href=\"https://doi.org/10.1128/genomeA.00216-13\">10.1128/genomeA.00216-13</a>","chicago":"Fernandes Redondo, Rodrigo A, Anne Kupczok, Gertraud Stift, and Jonathan P Bollback. “Complete Genome Sequence of the Novel Phage MG-B1 Infecting Bacillus Weihenstephanensis.” <i>Genome Announcements</i>. American Society for Microbiology, 2013. <a href=\"https://doi.org/10.1128/genomeA.00216-13\">https://doi.org/10.1128/genomeA.00216-13</a>.","apa":"Fernandes Redondo, R. A., Kupczok, A., Stift, G., &#38; Bollback, J. P. (2013). Complete genome sequence of the novel phage MG-B1 infecting bacillus weihenstephanensis. <i>Genome Announcements</i>. American Society for Microbiology. <a href=\"https://doi.org/10.1128/genomeA.00216-13\">https://doi.org/10.1128/genomeA.00216-13</a>","ista":"Fernandes Redondo RA, Kupczok A, Stift G, Bollback JP. 2013. Complete genome sequence of the novel phage MG-B1 infecting bacillus weihenstephanensis. Genome Announcements. 1(3).","ieee":"R. A. Fernandes Redondo, A. Kupczok, G. Stift, and J. P. Bollback, “Complete genome sequence of the novel phage MG-B1 infecting bacillus weihenstephanensis,” <i>Genome Announcements</i>, vol. 1, no. 3. American Society for Microbiology, 2013.","short":"R.A. Fernandes Redondo, A. Kupczok, G. Stift, J.P. Bollback, Genome Announcements 1 (2013)."},"has_accepted_license":"1","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Here, we describe a novel virulent bacteriophage that infects Bacillus weihenstephanensis, isolated from soil in Austria. It is the first phage to be discovered that infects this species. Here, we present the complete genome sequence of this podovirus. "}],"title":"Complete genome sequence of the novel phage MG-B1 infecting bacillus weihenstephanensis","_id":"2410","issue":"3","file_date_updated":"2020-07-14T12:45:40Z","scopus_import":1},{"department":[{"_id":"MiSi"},{"_id":"Bio"}],"year":"2013","language":[{"iso":"eng"}],"day":"18","publist_id":"3959","publication_status":"published","date_created":"2018-12-11T11:59:52Z","page":"328 - 332","author":[{"last_name":"Weber","id":"3A3FC708-F248-11E8-B48F-1D18A9856A87","first_name":"Michele","full_name":"Weber, Michele"},{"first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","last_name":"Hauschild"},{"last_name":"Schwarz","full_name":"Schwarz, Jan","first_name":"Jan","id":"346C1EC6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Moussion","full_name":"Moussion, Christine","id":"3356F664-F248-11E8-B48F-1D18A9856A87","first_name":"Christine"},{"first_name":"Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","full_name":"De Vries, Ingrid","last_name":"De Vries"},{"full_name":"Legler, Daniel","first_name":"Daniel","last_name":"Legler"},{"full_name":"Luther, Sanjiv","first_name":"Sanjiv","last_name":"Luther"},{"orcid":"0000-0003-4398-476X","last_name":"Bollenbach","full_name":"Bollenbach, Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Mark Tobias"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","full_name":"Sixt, Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179"}],"oa":1,"quality_controlled":"1","month":"01","publisher":"American Association for the Advancement of Science","date_updated":"2022-06-10T10:21:40Z","doi":"10.1126/science.1228456","publication":"Science","article_processing_charge":"No","article_type":"original","oa_version":"Published Version","type":"journal_article","date_published":"2013-01-18T00:00:00Z","project":[{"_id":"25A603A2-B435-11E9-9278-68D0E5697425","grant_number":"281556","name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","call_identifier":"FP7"},{"name":"Cell migration in complex environments: from in vivo experiments to theoretical models","grant_number":"RGP0058/2011","_id":"25ABD200-B435-11E9-9278-68D0E5697425"}],"volume":339,"scopus_import":"1","issue":"6117","acknowledgement":"We thank M. Frank for technical assistance and S. Cremer, P. Schmalhorst, and E. Kiermaier for critical reading of the manuscript. This work was supported by a Humboldt Foundation postdoctoral fellowship (to M.W.), the German Research Foundation (Si1323 1,2 to M.S.), the Human Frontier Science Program (HFSP RGP0058/2011 to M.S.), the European Research Council (ERC StG 281556 to M.S.), and the Swiss National Science Foundation (31003A 127474 to D.F.L., 130488 to S.A.L.).","title":"Interstitial dendritic cell guidance by haptotactic chemokine gradients","_id":"2839","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Directional guidance of cells via gradients of chemokines is considered crucial for embryonic development, cancer dissemination, and immune responses. Nevertheless, the concept still lacks direct experimental confirmation in vivo. Here, we identify endogenous gradients of the chemokine CCL21 within mouse skin and show that they guide dendritic cells toward lymphatic vessels. Quantitative imaging reveals depots of CCL21 within lymphatic endothelial cells and steeply decaying gradients within the perilymphatic interstitium. These gradients match the migratory patterns of the dendritic cells, which directionally approach vessels from a distance of up to 90-micrometers. Interstitial CCL21 is immobilized to heparan sulfates, and its experimental delocalization or swamping the endogenous gradients abolishes directed migration. These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues."}],"citation":{"mla":"Weber, Michele, et al. “Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients.” <i>Science</i>, vol. 339, no. 6117, American Association for the Advancement of Science, 2013, pp. 328–32, doi:<a href=\"https://doi.org/10.1126/science.1228456\">10.1126/science.1228456</a>.","ama":"Weber M, Hauschild R, Schwarz J, et al. Interstitial dendritic cell guidance by haptotactic chemokine gradients. <i>Science</i>. 2013;339(6117):328-332. doi:<a href=\"https://doi.org/10.1126/science.1228456\">10.1126/science.1228456</a>","chicago":"Weber, Michele, Robert Hauschild, Jan Schwarz, Christine Moussion, Ingrid de Vries, Daniel Legler, Sanjiv Luther, Mark Tobias Bollenbach, and Michael K Sixt. “Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients.” <i>Science</i>. American Association for the Advancement of Science, 2013. <a href=\"https://doi.org/10.1126/science.1228456\">https://doi.org/10.1126/science.1228456</a>.","apa":"Weber, M., Hauschild, R., Schwarz, J., Moussion, C., de Vries, I., Legler, D., … Sixt, M. K. (2013). Interstitial dendritic cell guidance by haptotactic chemokine gradients. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1228456\">https://doi.org/10.1126/science.1228456</a>","ista":"Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler D, Luther S, Bollenbach MT, Sixt MK. 2013. Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science. 339(6117), 328–332.","short":"M. Weber, R. Hauschild, J. Schwarz, C. Moussion, I. de Vries, D. Legler, S. Luther, M.T. Bollenbach, M.K. Sixt, Science 339 (2013) 328–332.","ieee":"M. Weber <i>et al.</i>, “Interstitial dendritic cell guidance by haptotactic chemokine gradients,” <i>Science</i>, vol. 339, no. 6117. American Association for the Advancement of Science, pp. 328–332, 2013."},"intvolume":"       339","main_file_link":[{"url":"https://kops.uni-konstanz.de/bitstream/123456789/26341/2/Weber_263418.pdf","open_access":"1"}],"status":"public","ec_funded":1},{"department":[{"_id":"E-Lib"}],"file_date_updated":"2020-07-14T12:46:44Z","language":[{"iso":"eng"}],"ddc":["020"],"year":"2012","date_created":"2018-12-12T11:39:06Z","day":"12","publication_status":"published","author":[{"full_name":"Porsche, Jana","id":"3252EDC2-F248-11E8-B48F-1D18A9856A87","first_name":"Jana","last_name":"Porsche"}],"pubrep_id":"103","month":"11","file":[{"creator":"system","relation":"main_file","content_type":"application/pdf","date_created":"2018-12-12T11:53:11Z","file_id":"5472","date_updated":"2020-07-14T12:46:44Z","file_size":238544,"file_name":"IST-2012-103-v1+1_Actual_state_of_research_data_@_IST_Austria.pdf","access_level":"open_access","checksum":"e0a7c041eea1ca4b70ab6f9ec5177f4e"}],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"This document is created as a part of the project “Repository for Research Data on IST Austria”. It summarises the actual state of research data at IST Austria, based on survey results. It supports the choice of appropriate software, which would best fit the requirements of their users, the researchers."}],"date_updated":"2020-07-14T23:04:49Z","publisher":"IST Austria","title":"Actual state of research data @ ISTAustria","_id":"5398","oa_version":"Published Version","citation":{"short":"J. Porsche, Actual State of Research Data @ ISTAustria, IST Austria, 2012.","ieee":"J. Porsche, <i>Actual state of research data @ ISTAustria</i>. IST Austria, 2012.","apa":"Porsche, J. (2012). <i>Actual state of research data @ ISTAustria</i>. IST Austria.","ista":"Porsche J. 2012. Actual state of research data @ ISTAustria, IST Austria,p.","chicago":"Porsche, Jana. <i>Actual State of Research Data @ ISTAustria</i>. IST Austria, 2012.","mla":"Porsche, Jana. <i>Actual State of Research Data @ ISTAustria</i>. IST Austria, 2012.","ama":"Porsche J. <i>Actual State of Research Data @ ISTAustria</i>. IST Austria; 2012."},"has_accepted_license":"1","date_published":"2012-11-12T00:00:00Z","type":"report","status":"public"}]