---
_id: '3395'
abstract:
- lang: eng
  text: Defining population structure and genetic diversity levels is of the utmost
    importance for developing efficient conservation strategies. Overfishing has caused
    mean annual catches of the European spiny lobster (Palinurus elephas) to decrease
    alarmingly along its distribution area. In this context, there is a need for comprehensive
    studies aiming to evaluate the genetic health of the exploited populations. The
    present study is based on a set of ten nuclear markers amplified in 331 individuals
    from ten different localities covering most of P. elephas distribution area. Samples
    from Atlantic and Mediterranean basins showed small but significant differences,
    indicating that P. elephas populations do not behave as a single panmictic unit
    but form two partially-overlapping groups. Despite intense overfishing, our dataset
    did not recover a recent bottleneck signal, and instead showed a large and stable
    historical effective size. This result could be accounted for by specific life-history
    traits (reproduction and longevity) and the limitations of molecular markers in
    covering recent timescales for nontemporal samples. The findings of the present
    study emphasize the need to integrate information on effective population sizes
    and life-history parameters when evaluating population connectivity levels from
    genetic data.
acknowledgement: This work was supported by a pre-doctoral fellowship awarded by the
  Autonomous Government of Catalonia to F.P. (2006FIC-00082). Research was funded
  by projects FBBVA-BIOCON 08-187/09, CGL2006-13423, and CTM2007-66635. The authors
  are part of the research group 2009SGR-636, 2009SGR-655, and 2009SGR-1364 of the
  Generalitat de Catalunya. F.P. acknowledges EU-Synthesys grant (GB-TAF-4474).
article_processing_charge: No
author:
- first_name: Ferran
  full_name: Palero, Ferran
  id: 3F0E2A22-F248-11E8-B48F-1D18A9856A87
  last_name: Palero
  orcid: 0000-0002-0343-8329
- first_name: Pere
  full_name: Abello, Pere
  last_name: Abello
- first_name: Enrique
  full_name: Macpherson, Enrique
  last_name: Macpherson
- first_name: Mark
  full_name: Beaumont, Mark
  last_name: Beaumont
- first_name: Marta
  full_name: Pascual, Marta
  last_name: Pascual
citation:
  ama: Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. Effect of oceanographic
    barriers and overfishing on the population genetic structure of the European spiny
    lobster Palinurus elephas. <i>Biological Journal of the Linnean Society</i>. 2011;104(2):407-418.
    doi:<a href="https://doi.org/10.1111/j.1095-8312.2011.01728.x">10.1111/j.1095-8312.2011.01728.x</a>
  apa: Palero, F., Abello, P., Macpherson, E., Beaumont, M., &#38; Pascual, M. (2011).
    Effect of oceanographic barriers and overfishing on the population genetic structure
    of the European spiny lobster Palinurus elephas. <i>Biological Journal of the
    Linnean Society</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1095-8312.2011.01728.x">https://doi.org/10.1111/j.1095-8312.2011.01728.x</a>
  chicago: Palero, Ferran, Pere Abello, Enrique Macpherson, Mark Beaumont, and Marta
    Pascual. “Effect of Oceanographic Barriers and Overfishing on the Population Genetic
    Structure of the European Spiny Lobster Palinurus Elephas.” <i>Biological Journal
    of the Linnean Society</i>. Wiley-Blackwell, 2011. <a href="https://doi.org/10.1111/j.1095-8312.2011.01728.x">https://doi.org/10.1111/j.1095-8312.2011.01728.x</a>.
  ieee: F. Palero, P. Abello, E. Macpherson, M. Beaumont, and M. Pascual, “Effect
    of oceanographic barriers and overfishing on the population genetic structure
    of the European spiny lobster Palinurus elephas,” <i>Biological Journal of the
    Linnean Society</i>, vol. 104, no. 2. Wiley-Blackwell, pp. 407–418, 2011.
  ista: Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. 2011. Effect of oceanographic
    barriers and overfishing on the population genetic structure of the European spiny
    lobster Palinurus elephas. Biological Journal of the Linnean Society. 104(2),
    407–418.
  mla: Palero, Ferran, et al. “Effect of Oceanographic Barriers and Overfishing on
    the Population Genetic Structure of the European Spiny Lobster Palinurus Elephas.”
    <i>Biological Journal of the Linnean Society</i>, vol. 104, no. 2, Wiley-Blackwell,
    2011, pp. 407–18, doi:<a href="https://doi.org/10.1111/j.1095-8312.2011.01728.x">10.1111/j.1095-8312.2011.01728.x</a>.
  short: F. Palero, P. Abello, E. Macpherson, M. Beaumont, M. Pascual, Biological
    Journal of the Linnean Society 104 (2011) 407–418.
date_created: 2018-12-11T12:03:06Z
date_published: 2011-09-14T00:00:00Z
date_updated: 2023-02-23T14:07:31Z
day: '14'
department:
- _id: NiBa
doi: 10.1111/j.1095-8312.2011.01728.x
intvolume: '       104'
issue: '2'
language:
- iso: eng
month: '09'
oa_version: None
page: 407 - 418
publication: Biological Journal of the Linnean Society
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3212'
quality_controlled: '1'
related_material:
  record:
  - id: '9762'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Effect of oceanographic barriers and overfishing on the population genetic
  structure of the European spiny lobster Palinurus elephas
type: journal_article
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
volume: 104
year: '2011'
...
---
_id: '3396'
abstract:
- lang: eng
  text: Facial branchiomotor neurons (FBMNs) in zebrafish and mouse embryonic hindbrain
    undergo a characteristic tangential migration from rhombomere (r) 4, where they
    are born, to r6/7. Cohesion among neuroepithelial cells (NCs) has been suggested
    to function in FBMN migration by inhibiting FBMNs positioned in the basal neuroepithelium
    such that they move apically between NCs towards the midline of the neuroepithelium
    instead of tangentially along the basal side of the neuroepithelium towards r6/7.
    However, direct experimental evaluation of this hypothesis is still lacking. Here,
    we have used a combination of biophysical cell adhesion measurements and high-resolution
    time-lapse microscopy to determine the role of NC cohesion in FBMN migration.
    We show that reducing NC cohesion by interfering with Cadherin 2 (Cdh2) activity
    results in FBMNs positioned at the basal side of the neuroepithelium moving apically
    towards the neural tube midline instead of tangentially towards r6/7. In embryos
    with strongly reduced NC cohesion, ectopic apical FBMN movement frequently results
    in fusion of the bilateral FBMN clusters over the apical midline of the neural
    tube. By contrast, reducing cohesion among FBMNs by interfering with Contactin
    2 (Cntn2) expression in these cells has little effect on apical FBMN movement,
    but reduces the fusion of the bilateral FBMN clusters in embryos with strongly
    diminished NC cohesion. These data provide direct experimental evidence that NC
    cohesion functions in tangential FBMN migration by restricting their apical movement.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
article_type: original
author:
- first_name: Petra
  full_name: Stockinger, Petra
  id: 261CB030-E90D-11E9-B182-F697D44B663C
  last_name: Stockinger
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Jean-Léon
  full_name: Maître, Jean-Léon
  id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
  last_name: Maître
  orcid: 0000-0002-3688-1474
citation:
  ama: Stockinger P, Heisenberg C-PJ, Maître J-L. Defective neuroepithelial cell cohesion
    affects tangential branchiomotor neuron migration in the zebrafish neural tube.
    <i>Development</i>. 2011;138(21):4673-4683. doi:<a href="https://doi.org/10.1242/dev.071233">10.1242/dev.071233</a>
  apa: Stockinger, P., Heisenberg, C.-P. J., &#38; Maître, J.-L. (2011). Defective
    neuroepithelial cell cohesion affects tangential branchiomotor neuron migration
    in the zebrafish neural tube. <i>Development</i>. Company of Biologists. <a href="https://doi.org/10.1242/dev.071233">https://doi.org/10.1242/dev.071233</a>
  chicago: Stockinger, Petra, Carl-Philipp J Heisenberg, and Jean-Léon Maître. “Defective
    Neuroepithelial Cell Cohesion Affects Tangential Branchiomotor Neuron Migration
    in the Zebrafish Neural Tube.” <i>Development</i>. Company of Biologists, 2011.
    <a href="https://doi.org/10.1242/dev.071233">https://doi.org/10.1242/dev.071233</a>.
  ieee: P. Stockinger, C.-P. J. Heisenberg, and J.-L. Maître, “Defective neuroepithelial
    cell cohesion affects tangential branchiomotor neuron migration in the zebrafish
    neural tube,” <i>Development</i>, vol. 138, no. 21. Company of Biologists, pp.
    4673–4683, 2011.
  ista: Stockinger P, Heisenberg C-PJ, Maître J-L. 2011. Defective neuroepithelial
    cell cohesion affects tangential branchiomotor neuron migration in the zebrafish
    neural tube. Development. 138(21), 4673–4683.
  mla: Stockinger, Petra, et al. “Defective Neuroepithelial Cell Cohesion Affects
    Tangential Branchiomotor Neuron Migration in the Zebrafish Neural Tube.” <i>Development</i>,
    vol. 138, no. 21, Company of Biologists, 2011, pp. 4673–83, doi:<a href="https://doi.org/10.1242/dev.071233">10.1242/dev.071233</a>.
  short: P. Stockinger, C.-P.J. Heisenberg, J.-L. Maître, Development 138 (2011) 4673–4683.
date_created: 2018-12-11T12:03:06Z
date_published: 2011-09-28T00:00:00Z
date_updated: 2021-01-12T07:43:11Z
day: '28'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1242/dev.071233
file:
- access_level: open_access
  checksum: ca12b79e01ef36c1ef1aea31cf7e7139
  content_type: application/pdf
  creator: dernst
  date_created: 2019-10-07T14:19:42Z
  date_updated: 2020-07-14T12:46:12Z
  file_id: '6930'
  file_name: 2011_Development_Stockinger.pdf
  file_size: 4672439
  relation: main_file
file_date_updated: 2020-07-14T12:46:12Z
has_accepted_license: '1'
intvolume: '       138'
issue: '21'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 4673 - 4683
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '3210'
quality_controlled: '1'
scopus_import: 1
status: public
title: Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron
  migration in the zebrafish neural tube
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 138
year: '2011'
...
---
_id: '3397'
abstract:
- lang: eng
  text: Recent advances in microscopy techniques and biophysical measurements have
    provided novel insight into the molecular, cellular and biophysical basis of cell
    adhesion. However, comparably little is known about a core element of cell–cell
    adhesion—the energy of adhesion at the cell–cell contact. In this review, we discuss
    approaches to understand the nature and regulation of adhesion energy, and propose
    strategies to determine adhesion energy between cells in vitro and in vivo.
author:
- first_name: Jean-Léon
  full_name: Maître, Jean-Léon
  id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
  last_name: Maître
  orcid: 0000-0002-3688-1474
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Maître J-L, Heisenberg C-PJ. The role of adhesion energy in controlling cell-cell
    contacts. <i>Current Opinion in Cell Biology</i>. 2011;23(5):508-514. doi:<a href="https://doi.org/10.1016/j.ceb.2011.07.004">10.1016/j.ceb.2011.07.004</a>
  apa: Maître, J.-L., &#38; Heisenberg, C.-P. J. (2011). The role of adhesion energy
    in controlling cell-cell contacts. <i>Current Opinion in Cell Biology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.ceb.2011.07.004">https://doi.org/10.1016/j.ceb.2011.07.004</a>
  chicago: Maître, Jean-Léon, and Carl-Philipp J Heisenberg. “The Role of Adhesion
    Energy in Controlling Cell-Cell Contacts.” <i>Current Opinion in Cell Biology</i>.
    Elsevier, 2011. <a href="https://doi.org/10.1016/j.ceb.2011.07.004">https://doi.org/10.1016/j.ceb.2011.07.004</a>.
  ieee: J.-L. Maître and C.-P. J. Heisenberg, “The role of adhesion energy in controlling
    cell-cell contacts,” <i>Current Opinion in Cell Biology</i>, vol. 23, no. 5. Elsevier,
    pp. 508–514, 2011.
  ista: Maître J-L, Heisenberg C-PJ. 2011. The role of adhesion energy in controlling
    cell-cell contacts. Current Opinion in Cell Biology. 23(5), 508–514.
  mla: Maître, Jean-Léon, and Carl-Philipp J. Heisenberg. “The Role of Adhesion Energy
    in Controlling Cell-Cell Contacts.” <i>Current Opinion in Cell Biology</i>, vol.
    23, no. 5, Elsevier, 2011, pp. 508–14, doi:<a href="https://doi.org/10.1016/j.ceb.2011.07.004">10.1016/j.ceb.2011.07.004</a>.
  short: J.-L. Maître, C.-P.J. Heisenberg, Current Opinion in Cell Biology 23 (2011)
    508–514.
date_created: 2018-12-11T12:03:06Z
date_published: 2011-10-01T00:00:00Z
date_updated: 2021-01-12T07:43:12Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.ceb.2011.07.004
intvolume: '        23'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188705/
month: '10'
oa: 1
oa_version: Submitted Version
page: 508 - 514
publication: Current Opinion in Cell Biology
publication_status: published
publisher: Elsevier
publist_id: '3211'
quality_controlled: '1'
scopus_import: 1
status: public
title: The role of adhesion energy in controlling cell-cell contacts
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2011'
...
---
_id: '3399'
abstract:
- lang: eng
  text: Context-dependent adjustment of mating tactics can drastically increase the
    mating success of behaviourally flexible animals. We used the ant Cardiocondyla
    obscurior as a model system to study adaptive adjustment of male mating tactics.
    This species shows a male diphenism of wingless fighter males and peaceful winged
    males. Whereas the wingless males stay and exclusively mate in the maternal colony,
    the mating behaviour of winged males is plastic. They copulate with female sexuals
    in their natal nests early in life but later disperse in search for sexuals outside.
    In this study, we observed the nest-leaving behaviour of winged males under different
    conditions and found that they adaptively adjust the timing of their dispersal
    to the availability of mating partners, as well as the presence, and even the
    type of competitors in their natal nests. In colonies with virgin female queens
    winged males stayed longest when they were the only male in the nest. They left
    earlier when mating partners were not available or when other males were present.
    In the presence of wingless, locally mating fighter males, winged males dispersed
    earlier than in the presence of docile, winged competitors. This suggests that
    C. obscurior males are capable of estimating their local breeding chances and
    adaptively adjust their dispersal behaviour in both an opportunistic and a risk-sensitive
    way, thus showing hitherto unknown behavioural plasticity in social insect males.
acknowledgement: This work was supported by the German Science Foundation (www.dfg.de,
  He 1623/23).
article_number: e17323
author:
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Alexandra
  full_name: Schrempf, Alexandra
  last_name: Schrempf
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
citation:
  ama: Cremer S, Schrempf A, Heinze J. Competition and opportunity shape the reproductive
    tactics of males in the ant Cardiocondyla obscurior. <i>PLoS One</i>. 2011;6(3).
    doi:<a href="https://doi.org/10.1371/journal.pone.0017323">10.1371/journal.pone.0017323</a>
  apa: Cremer, S., Schrempf, A., &#38; Heinze, J. (2011). Competition and opportunity
    shape the reproductive tactics of males in the ant Cardiocondyla obscurior. <i>PLoS
    One</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0017323">https://doi.org/10.1371/journal.pone.0017323</a>
  chicago: Cremer, Sylvia, Alexandra Schrempf, and Jürgen Heinze. “Competition and
    Opportunity Shape the Reproductive Tactics of Males in the Ant Cardiocondyla Obscurior.”
    <i>PLoS One</i>. Public Library of Science, 2011. <a href="https://doi.org/10.1371/journal.pone.0017323">https://doi.org/10.1371/journal.pone.0017323</a>.
  ieee: S. Cremer, A. Schrempf, and J. Heinze, “Competition and opportunity shape
    the reproductive tactics of males in the ant Cardiocondyla obscurior,” <i>PLoS
    One</i>, vol. 6, no. 3. Public Library of Science, 2011.
  ista: Cremer S, Schrempf A, Heinze J. 2011. Competition and opportunity shape the
    reproductive tactics of males in the ant Cardiocondyla obscurior. PLoS One. 6(3),
    e17323.
  mla: Cremer, Sylvia, et al. “Competition and Opportunity Shape the Reproductive
    Tactics of Males in the Ant Cardiocondyla Obscurior.” <i>PLoS One</i>, vol. 6,
    no. 3, e17323, Public Library of Science, 2011, doi:<a href="https://doi.org/10.1371/journal.pone.0017323">10.1371/journal.pone.0017323</a>.
  short: S. Cremer, A. Schrempf, J. Heinze, PLoS One 6 (2011).
date_created: 2018-12-11T12:03:07Z
date_published: 2011-03-29T00:00:00Z
date_updated: 2021-01-12T07:43:12Z
day: '29'
ddc:
- '576'
department:
- _id: SyCr
doi: 10.1371/journal.pone.0017323
file:
- access_level: open_access
  checksum: 46f8cbde61f06fcacf8fa297cacfa0e5
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:40Z
  date_updated: 2020-07-14T12:46:12Z
  file_id: '5162'
  file_name: IST-2015-377-v1+1_journal.pone.0017323.pdf
  file_size: 147367
  relation: main_file
file_date_updated: 2020-07-14T12:46:12Z
has_accepted_license: '1'
intvolume: '         6'
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3059'
pubrep_id: '377'
quality_controlled: '1'
scopus_import: 1
status: public
title: Competition and opportunity shape the reproductive tactics of males in the
  ant Cardiocondyla obscurior
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2011'
...
---
_id: '3405'
abstract:
- lang: eng
  text: Glutamate is the major excitatory neurotransmitter in the mammalian central
    nervous system and gates non-selective cation channels. The origins of glutamate
    receptors are not well understood as they differ structurally and functionally
    from simple bacterial ligand-gated ion channels. Here we report the discovery
    of an ionotropic glutamate receptor that combines the typical eukaryotic domain
    architecture with the 'TXVGYG' signature sequence of the selectivity filter found
    in K+ channels. This receptor exhibits functional properties intermediate between
    bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the
    evolution of ionotropic glutamate receptors.
author:
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Guillaume
  full_name: Sandoz, Guillaume
  last_name: Sandoz
- first_name: Ehud
  full_name: Isacoff, Ehud
  last_name: Isacoff
citation:
  ama: Janovjak HL, Sandoz G, Isacoff E. Modern ionotropic glutamate receptor with
    a K+ selectivity signature sequence. <i>Nature Communications</i>. 2011;2(232):1-6.
    doi:<a href="https://doi.org/10.1038/ncomms1231">10.1038/ncomms1231</a>
  apa: Janovjak, H. L., Sandoz, G., &#38; Isacoff, E. (2011). Modern ionotropic glutamate
    receptor with a K+ selectivity signature sequence. <i>Nature Communications</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/ncomms1231">https://doi.org/10.1038/ncomms1231</a>
  chicago: Janovjak, Harald L, Guillaume Sandoz, and Ehud Isacoff. “Modern Ionotropic
    Glutamate Receptor with a K+ Selectivity Signature Sequence.” <i>Nature Communications</i>.
    Nature Publishing Group, 2011. <a href="https://doi.org/10.1038/ncomms1231">https://doi.org/10.1038/ncomms1231</a>.
  ieee: H. L. Janovjak, G. Sandoz, and E. Isacoff, “Modern ionotropic glutamate receptor
    with a K+ selectivity signature sequence,” <i>Nature Communications</i>, vol.
    2, no. 232. Nature Publishing Group, pp. 1–6, 2011.
  ista: Janovjak HL, Sandoz G, Isacoff E. 2011. Modern ionotropic glutamate receptor
    with a K+ selectivity signature sequence. Nature Communications. 2(232), 1–6.
  mla: Janovjak, Harald L., et al. “Modern Ionotropic Glutamate Receptor with a K+
    Selectivity Signature Sequence.” <i>Nature Communications</i>, vol. 2, no. 232,
    Nature Publishing Group, 2011, pp. 1–6, doi:<a href="https://doi.org/10.1038/ncomms1231">10.1038/ncomms1231</a>.
  short: H.L. Janovjak, G. Sandoz, E. Isacoff, Nature Communications 2 (2011) 1–6.
date_created: 2018-12-11T12:03:09Z
date_published: 2011-03-08T00:00:00Z
date_updated: 2021-01-12T07:43:15Z
day: '08'
ddc:
- '570'
- '571'
department:
- _id: HaJa
doi: 10.1038/ncomms1231
file:
- access_level: open_access
  checksum: 6b68d65aadd97c18d663eb117a0a9d35
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:36Z
  date_updated: 2020-07-14T12:46:12Z
  file_id: '4891'
  file_name: IST-2017-832-v1+1_janovjak.pdf
  file_size: 387654
  relation: main_file
file_date_updated: 2020-07-14T12:46:12Z
has_accepted_license: '1'
intvolume: '         2'
issue: '232'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1 - 6
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '2997'
pubrep_id: '832'
quality_controlled: '1'
scopus_import: 1
status: public
title: Modern ionotropic glutamate receptor with a K+ selectivity signature sequence
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2011'
...
---
_id: '3429'
abstract:
- lang: eng
  text: Transcription factors are central to sustaining pluripotency, yet little is
    known about transcription factor dynamics in defining pluripotency in the early
    mammalian embryo. Here, we establish a fluorescence decay after photoactivation
    (FDAP) assay to quantitatively study the kinetic behaviour of Oct4, a key transcription
    factor controlling pre-implantation development in the mouse embryo. FDAP measurements
    reveal that each cell in a developing embryo shows one of two distinct Oct4 kinetics,
    before there are any morphologically distinguishable differences or outward signs
    of lineage patterning. The differences revealed by FDAP are due to differences
    in the accessibility of Oct4 to its DNA binding sites in the nucleus. Lineage
    tracing of the cells in the two distinct sub-populations demonstrates that the
    Oct4 kinetics predict lineages of the early embryo. Cells with slower Oct4 kinetics
    are more likely to give rise to the pluripotent cell lineage that contributes
    to the inner cell mass. Those with faster Oct4 kinetics contribute mostly to the
    extra-embryonic lineage. Our findings identify Oct4 kinetics, rather than differences
    in total transcription factor expression levels, as a predictive measure of developmental
    cell lineage patterning in the early mouse embryo.
acknowledgement: This work was supported by the Beckman Institute and Biological Imaging
  Center at the California Institute of Technology and by the NHGRI Center of Excellence
  in Genomic Science grant P50HG004071.
author:
- first_name: Nicolas
  full_name: Plachta, Nicolas
  last_name: Plachta
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Shirley
  full_name: Pease, Shirley
  last_name: Pease
- first_name: Scott
  full_name: Fraser, Scott
  last_name: Fraser
- first_name: Periklis
  full_name: Pantazis, Periklis
  last_name: Pantazis
citation:
  ama: Plachta N, Bollenbach MT, Pease S, Fraser S, Pantazis P. Oct4 kinetics predict
    cell lineage patterning in the early mammalian embryo. <i>Nature Cell Biology</i>.
    2011;13(2):117-123. doi:<a href="https://doi.org/10.1038/ncb2154">10.1038/ncb2154</a>
  apa: Plachta, N., Bollenbach, M. T., Pease, S., Fraser, S., &#38; Pantazis, P. (2011).
    Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. <i>Nature
    Cell Biology</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/ncb2154">https://doi.org/10.1038/ncb2154</a>
  chicago: Plachta, Nicolas, Mark Tobias Bollenbach, Shirley Pease, Scott Fraser,
    and Periklis Pantazis. “Oct4 Kinetics Predict Cell Lineage Patterning in the Early
    Mammalian Embryo.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2011.
    <a href="https://doi.org/10.1038/ncb2154">https://doi.org/10.1038/ncb2154</a>.
  ieee: N. Plachta, M. T. Bollenbach, S. Pease, S. Fraser, and P. Pantazis, “Oct4
    kinetics predict cell lineage patterning in the early mammalian embryo,” <i>Nature
    Cell Biology</i>, vol. 13, no. 2. Nature Publishing Group, pp. 117–123, 2011.
  ista: Plachta N, Bollenbach MT, Pease S, Fraser S, Pantazis P. 2011. Oct4 kinetics
    predict cell lineage patterning in the early mammalian embryo. Nature Cell Biology.
    13(2), 117–123.
  mla: Plachta, Nicolas, et al. “Oct4 Kinetics Predict Cell Lineage Patterning in
    the Early Mammalian Embryo.” <i>Nature Cell Biology</i>, vol. 13, no. 2, Nature
    Publishing Group, 2011, pp. 117–23, doi:<a href="https://doi.org/10.1038/ncb2154">10.1038/ncb2154</a>.
  short: N. Plachta, M.T. Bollenbach, S. Pease, S. Fraser, P. Pantazis, Nature Cell
    Biology 13 (2011) 117–123.
date_created: 2018-12-11T12:03:17Z
date_published: 2011-01-23T00:00:00Z
date_updated: 2021-01-12T07:43:24Z
day: '23'
department:
- _id: ToBo
doi: 10.1038/ncb2154
intvolume: '        13'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 117 - 123
publication: Nature Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '2971'
scopus_import: 1
status: public
title: Oct4 kinetics predict cell lineage patterning in the early mammalian embryo
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2011'
...
---
_id: '3505'
abstract:
- lang: eng
  text: Cell migration on two-dimensional (2D) substrates follows entirely different
    rules than cell migration in three-dimensional (3D) environments. This is especially
    relevant for leukocytes that are able to migrate in the absence of adhesion receptors
    within the confined geometry of artificial 3D extracellular matrix scaffolds and
    within the interstitial space in vivo. Here, we describe in detail a simple and
    economical protocol to visualize dendritic cell migration in 3D collagen scaffolds
    along chemotactic gradients. This method can be adapted to other cell types and
    may serve as a physiologically relevant paradigm for the directed locomotion of
    most amoeboid cells.
alternative_title:
- Methods in Molecular Biology
article_processing_charge: No
article_type: original
author:
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Tim
  full_name: Lämmermann, Tim
  last_name: Lämmermann
citation:
  ama: Sixt MK, Lämmermann T. In vitro analysis of chemotactic leukocyte migration
    in 3D environments. <i>Cell Migration</i>. 2011;769:149-165. doi:<a href="https://doi.org/10.1007/978-1-61779-207-6_11">10.1007/978-1-61779-207-6_11</a>
  apa: Sixt, M. K., &#38; Lämmermann, T. (2011). In vitro analysis of chemotactic
    leukocyte migration in 3D environments. <i>Cell Migration</i>. Springer. <a href="https://doi.org/10.1007/978-1-61779-207-6_11">https://doi.org/10.1007/978-1-61779-207-6_11</a>
  chicago: Sixt, Michael K, and Tim Lämmermann. “In Vitro Analysis of Chemotactic
    Leukocyte Migration in 3D Environments.” <i>Cell Migration</i>. Springer, 2011.
    <a href="https://doi.org/10.1007/978-1-61779-207-6_11">https://doi.org/10.1007/978-1-61779-207-6_11</a>.
  ieee: M. K. Sixt and T. Lämmermann, “In vitro analysis of chemotactic leukocyte
    migration in 3D environments,” <i>Cell Migration</i>, vol. 769. Springer, pp.
    149–165, 2011.
  ista: Sixt MK, Lämmermann T. 2011. In vitro analysis of chemotactic leukocyte migration
    in 3D environments. Cell Migration. 769, 149–165.
  mla: Sixt, Michael K., and Tim Lämmermann. “In Vitro Analysis of Chemotactic Leukocyte
    Migration in 3D Environments.” <i>Cell Migration</i>, vol. 769, Springer, 2011,
    pp. 149–65, doi:<a href="https://doi.org/10.1007/978-1-61779-207-6_11">10.1007/978-1-61779-207-6_11</a>.
  short: M.K. Sixt, T. Lämmermann, Cell Migration 769 (2011) 149–165.
date_created: 2018-12-11T12:03:41Z
date_published: 2011-05-17T00:00:00Z
date_updated: 2021-01-12T07:43:55Z
day: '17'
department:
- _id: MiSi
doi: 10.1007/978-1-61779-207-6_11
intvolume: '       769'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://pure.mpg.de/pubman/item/item_3219628_1/component/file_3219630/Sixt%20et%20al..pdf
month: '05'
oa: 1
oa_version: Published Version
page: 149 - 165
publication: Cell Migration
publication_status: published
publisher: Springer
publist_id: '2882'
quality_controlled: '1'
status: public
title: In vitro analysis of chemotactic leukocyte migration in 3D environments
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 769
year: '2011'
...
---
_id: '3771'
abstract:
- lang: eng
  text: The small-sized frugivorous bat Carollia perspicillata is an understory specialist
    and occurs in a wide range of lowland habitats, tending to be more common in tropical
    dry or moist forests of South and Central America. Its sister species, Carollia
    brevicauda, occurs almost exclusively in the Amazon rainforest. A recent phylogeographic
    study proposed a hypothesis of origin and subsequent diversification for C. perspicillata
    along the Atlantic coastal forest of Brazil. Additionally, it also found two allopatric
    clades for C. brevicauda separated by the Amazon Basin. We used cytochrome b gene
    sequences and a more extensive sampling to test hypotheses related to the origin
    and diversification of C. perspicillata plus C. brevicauda clade in South America.
    The results obtained indicate that there are two sympatric evolutionary lineages
    within each species. In C. perspicillata, one lineage is limited to the Southern
    Atlantic Forest, whereas the other is widely distributed. Coalescent analysis
    points to a simultaneous origin for C. perspicillata and C. brevicauda, although
    no place for the diversification of each species can be firmly suggested. The
    phylogeographic pattern shown by C. perspicillata is also congruent with the Pleistocene
    refugia hypothesis as a likely vicariant phenomenon shaping the present distribution
    of its intraspecific lineages.
author:
- first_name: Ana
  full_name: Pavan, Ana
  last_name: Pavan
- first_name: Felipe
  full_name: Martins, Felipe
  last_name: Martins
- first_name: Fabrício
  full_name: Santos, Fabrício
  last_name: Santos
- first_name: Albert
  full_name: Ditchfield, Albert
  last_name: Ditchfield
- first_name: Rodrigo A
  full_name: Fernandes Redondo, Rodrigo A
  id: 409D5C96-F248-11E8-B48F-1D18A9856A87
  last_name: Fernandes Redondo
  orcid: 0000-0002-5837-2793
citation:
  ama: 'Pavan A, Martins F, Santos F, Ditchfield A, Fernandes Redondo RA. Patterns
    of diversification in two species of short-tailed bats (Carollia Gray, 1838):
    the effects of historical fragmentation of Brazilian rainforests. <i>Biological
    Journal of the Linnean Society</i>. 2011;102(3):527-539. doi:<a href="https://doi.org/10.1111/j.1095-8312.2010.01601.x">10.1111/j.1095-8312.2010.01601.x</a>'
  apa: 'Pavan, A., Martins, F., Santos, F., Ditchfield, A., &#38; Fernandes Redondo,
    R. A. (2011). Patterns of diversification in two species of short-tailed bats
    (Carollia Gray, 1838): the effects of historical fragmentation of Brazilian rainforests.
    <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1095-8312.2010.01601.x">https://doi.org/10.1111/j.1095-8312.2010.01601.x</a>'
  chicago: 'Pavan, Ana, Felipe Martins, Fabrício Santos, Albert Ditchfield, and Rodrigo
    A Fernandes Redondo. “Patterns of Diversification in Two Species of Short-Tailed
    Bats (Carollia Gray, 1838): The Effects of Historical Fragmentation of Brazilian
    Rainforests.” <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell,
    2011. <a href="https://doi.org/10.1111/j.1095-8312.2010.01601.x">https://doi.org/10.1111/j.1095-8312.2010.01601.x</a>.'
  ieee: 'A. Pavan, F. Martins, F. Santos, A. Ditchfield, and R. A. Fernandes Redondo,
    “Patterns of diversification in two species of short-tailed bats (Carollia Gray,
    1838): the effects of historical fragmentation of Brazilian rainforests.,” <i>Biological
    Journal of the Linnean Society</i>, vol. 102, no. 3. Wiley-Blackwell, pp. 527–539,
    2011.'
  ista: 'Pavan A, Martins F, Santos F, Ditchfield A, Fernandes Redondo RA. 2011. Patterns
    of diversification in two species of short-tailed bats (Carollia Gray, 1838):
    the effects of historical fragmentation of Brazilian rainforests. Biological Journal
    of the Linnean Society. 102(3), 527–539.'
  mla: 'Pavan, Ana, et al. “Patterns of Diversification in Two Species of Short-Tailed
    Bats (Carollia Gray, 1838): The Effects of Historical Fragmentation of Brazilian
    Rainforests.” <i>Biological Journal of the Linnean Society</i>, vol. 102, no.
    3, Wiley-Blackwell, 2011, pp. 527–39, doi:<a href="https://doi.org/10.1111/j.1095-8312.2010.01601.x">10.1111/j.1095-8312.2010.01601.x</a>.'
  short: A. Pavan, F. Martins, F. Santos, A. Ditchfield, R.A. Fernandes Redondo, Biological
    Journal of the Linnean Society 102 (2011) 527–539.
date_created: 2018-12-11T12:05:05Z
date_published: 2011-02-10T00:00:00Z
date_updated: 2021-01-12T07:52:05Z
day: '10'
department:
- _id: FyKo
doi: 10.1111/j.1095-8312.2010.01601.x
intvolume: '       102'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 527 - 539
publication: Biological Journal of the Linnean Society
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2456'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Patterns of diversification in two species of short-tailed bats (Carollia
  Gray, 1838): the effects of historical fragmentation of Brazilian rainforests.'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 102
year: '2011'
...
---
_id: '3778'
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. Estimating linkage disequilibria. <i>Heredity</i>. 2011;106(2):205-206.
    doi:<a href="https://doi.org/10.1038/hdy.2010.67">10.1038/hdy.2010.67</a>
  apa: Barton, N. H. (2011). Estimating linkage disequilibria. <i>Heredity</i>. Nature
    Publishing Group. <a href="https://doi.org/10.1038/hdy.2010.67">https://doi.org/10.1038/hdy.2010.67</a>
  chicago: Barton, Nicholas H. “Estimating Linkage Disequilibria.” <i>Heredity</i>.
    Nature Publishing Group, 2011. <a href="https://doi.org/10.1038/hdy.2010.67">https://doi.org/10.1038/hdy.2010.67</a>.
  ieee: N. H. Barton, “Estimating linkage disequilibria,” <i>Heredity</i>, vol. 106,
    no. 2. Nature Publishing Group, pp. 205–206, 2011.
  ista: Barton NH. 2011. Estimating linkage disequilibria. Heredity. 106(2), 205–206.
  mla: Barton, Nicholas H. “Estimating Linkage Disequilibria.” <i>Heredity</i>, vol.
    106, no. 2, Nature Publishing Group, 2011, pp. 205–06, doi:<a href="https://doi.org/10.1038/hdy.2010.67">10.1038/hdy.2010.67</a>.
  short: N.H. Barton, Heredity 106 (2011) 205–206.
date_created: 2018-12-11T12:05:07Z
date_published: 2011-02-01T00:00:00Z
date_updated: 2021-01-12T07:52:08Z
day: '01'
department:
- _id: NiBa
doi: 10.1038/hdy.2010.67
external_id:
  pmid:
  - '20502479'
intvolume: '       106'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183869/
month: '02'
oa: 1
oa_version: Submitted Version
page: 205 - 206
pmid: 1
publication: Heredity
publication_status: published
publisher: Nature Publishing Group
publist_id: '2449'
scopus_import: 1
status: public
title: Estimating linkage disequilibria
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2011'
...
---
_id: '3781'
abstract:
- lang: eng
  text: We bound the difference in length of two curves in terms of their total curvatures
    and the Fréchet distance. The bound is independent of the dimension of the ambient
    Euclidean space, it improves upon a bound by Cohen-Steiner and Edelsbrunner, and
    it generalizes a result by Fáry and Chakerian.
acknowledgement: Funded by Graduate Aid in Areas of National Need (GAANN) Fellowship.
author:
- first_name: Brittany Terese
  full_name: Fasy, Brittany Terese
  id: F65D502E-E68D-11E9-9252-C644099818F6
  last_name: Fasy
citation:
  ama: Fasy BT. The difference in length of curves in R^n. <i>Acta Sci Math (Szeged)</i>.
    2011;77(1-2):359-367.
  apa: Fasy, B. T. (2011). The difference in length of curves in R^n. <i>Acta Sci.
    Math. (Szeged)</i>. Szegedi Tudományegyetem.
  chicago: Fasy, Brittany Terese. “The Difference in Length of Curves in R^n.” <i>Acta
    Sci. Math. (Szeged)</i>. Szegedi Tudományegyetem, 2011.
  ieee: B. T. Fasy, “The difference in length of curves in R^n,” <i>Acta Sci. Math.
    (Szeged)</i>, vol. 77, no. 1–2. Szegedi Tudományegyetem, pp. 359–367, 2011.
  ista: Fasy BT. 2011. The difference in length of curves in R^n. Acta Sci. Math.
    (Szeged). 77(1–2), 359–367.
  mla: Fasy, Brittany Terese. “The Difference in Length of Curves in R^n.” <i>Acta
    Sci. Math. (Szeged)</i>, vol. 77, no. 1–2, Szegedi Tudományegyetem, 2011, pp.
    359–67.
  short: B.T. Fasy, Acta Sci. Math. (Szeged) 77 (2011) 359–367.
date_created: 2018-12-11T12:05:08Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:09Z
day: '01'
department:
- _id: HeEd
intvolume: '        77'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 359 - 367
publication: Acta Sci. Math. (Szeged)
publication_status: published
publisher: Szegedi Tudományegyetem
publist_id: '2446'
quality_controlled: '1'
status: public
title: The difference in length of curves in R^n
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 77
year: '2011'
...
---
_id: '3784'
abstract:
- lang: eng
  text: Advanced stages of Scyllarus phyllosoma larvae were collected by demersal
    trawling during fishery research surveys in the western Mediterranean Sea in 2003–2005.
    Nucleotide sequence analysis of the mitochondrial 16S rDNA gene allowed the final-stage
    phyllosoma of Scyllarus arctus to be identified among these larvae. Its morphology
    is described and illustrated. This constitutes the second complete description
    of a Scyllaridae phyllosoma with its specific identity being validated by molecular
    techniques (the first was S. pygmaeus). These results also solved a long lasting
    taxonomic anomaly of several species assigned to the ancient genus Phyllosoma
    Leach, 1814. Detailed examination indicated that the final-stage phyllosoma of
    S. arctus shows closer affinities with the American scyllarid Scyllarus depressus
    or with the Australian Scyllarus sp. b (sensu Phillips et al., 1981) than to its
    sympatric species S. pygmaeus.
article_processing_charge: No
article_type: original
author:
- first_name: Ferran
  full_name: Palero, Ferran
  id: 3F0E2A22-F248-11E8-B48F-1D18A9856A87
  last_name: Palero
  orcid: 0000-0002-0343-8329
- first_name: Guillermo
  full_name: Guerao, Guillermo
  last_name: Guerao
- first_name: Paul
  full_name: Clark, Paul
  last_name: Clark
- first_name: Pere
  full_name: Abello, Pere
  last_name: Abello
citation:
  ama: 'Palero F, Guerao G, Clark P, Abello P. Scyllarus arctus (Crustacea: Decapoda:
    Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological
    description. <i>Journal of the Marine Biological Association of the United Kingdom</i>.
    2011;91(2):485-492. doi:<a href="https://doi.org/10.1017/S0025315410000287">10.1017/S0025315410000287</a>'
  apa: 'Palero, F., Guerao, G., Clark, P., &#38; Abello, P. (2011). Scyllarus arctus
    (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis,
    with morphological description. <i>Journal of the Marine Biological Association
    of the United Kingdom</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0025315410000287">https://doi.org/10.1017/S0025315410000287</a>'
  chicago: 'Palero, Ferran, Guillermo Guerao, Paul Clark, and Pere Abello. “Scyllarus
    Arctus (Crustacea: Decapoda: Scyllaridae) Final Stage Phyllosoma Identified by
    DNA Analysis, with Morphological Description.” <i>Journal of the Marine Biological
    Association of the United Kingdom</i>. Cambridge University Press, 2011. <a href="https://doi.org/10.1017/S0025315410000287">https://doi.org/10.1017/S0025315410000287</a>.'
  ieee: 'F. Palero, G. Guerao, P. Clark, and P. Abello, “Scyllarus arctus (Crustacea:
    Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with
    morphological description,” <i>Journal of the Marine Biological Association of
    the United Kingdom</i>, vol. 91, no. 2. Cambridge University Press, pp. 485–492,
    2011.'
  ista: 'Palero F, Guerao G, Clark P, Abello P. 2011. Scyllarus arctus (Crustacea:
    Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with
    morphological description. Journal of the Marine Biological Association of the
    United Kingdom. 91(2), 485–492.'
  mla: 'Palero, Ferran, et al. “Scyllarus Arctus (Crustacea: Decapoda: Scyllaridae)
    Final Stage Phyllosoma Identified by DNA Analysis, with Morphological Description.”
    <i>Journal of the Marine Biological Association of the United Kingdom</i>, vol.
    91, no. 2, Cambridge University Press, 2011, pp. 485–92, doi:<a href="https://doi.org/10.1017/S0025315410000287">10.1017/S0025315410000287</a>.'
  short: F. Palero, G. Guerao, P. Clark, P. Abello, Journal of the Marine Biological
    Association of the United Kingdom 91 (2011) 485–492.
date_created: 2018-12-11T12:05:09Z
date_published: 2011-03-01T00:00:00Z
date_updated: 2021-01-12T07:52:10Z
day: '01'
department:
- _id: NiBa
doi: 10.1017/S0025315410000287
intvolume: '        91'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://digital.csic.es/bitstream/10261/32783/3/Palero_et_al_2011.pdf
month: '03'
oa: 1
oa_version: Published Version
page: 485 - 492
publication: Journal of the Marine Biological Association of the United Kingdom
publication_status: published
publisher: Cambridge University Press
publist_id: '2443'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma
  identified by DNA analysis, with morphological description'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 91
year: '2011'
...
---
_id: '3791'
abstract:
- lang: eng
  text: During the development of multicellular organisms, cell fate specification
    is followed by the sorting of different cell types into distinct domains from
    where the different tissues and organs are formed. Cell sorting involves both
    the segregation of a mixed population of cells with different fates and properties
    into distinct domains, and the active maintenance of their segregated state. Because
    of its biological importance and apparent resemblance to fluid segregation in
    physics, cell sorting was extensively studied by both biologists and physicists
    over the last decades. Different theories were developed that try to explain cell
    sorting on the basis of the physical properties of the constituent cells. However,
    only recently the molecular and cellular mechanisms that control the physical
    properties driving cell sorting, have begun to be unraveled. In this review, we
    will provide an overview of different cell-sorting processes in development and
    discuss how these processes can be explained by the different sorting theories,
    and how these theories in turn can be connected to the molecular and cellular
    mechanisms driving these processes.
alternative_title:
- Current Topics in Developmental Biology
article_processing_charge: No
author:
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Krens G, Heisenberg C-PJ. Cell sorting in development. In: Labouesse M, ed.
    <i>Forces and Tension in Development</i>. Vol 95. Elsevier; 2011:189-213. doi:<a
    href="https://doi.org/10.1016/B978-0-12-385065-2.00006-2">10.1016/B978-0-12-385065-2.00006-2</a>'
  apa: Krens, G., &#38; Heisenberg, C.-P. J. (2011). Cell sorting in development.
    In M. Labouesse (Ed.), <i>Forces and Tension in Development</i> (Vol. 95, pp.
    189–213). Elsevier. <a href="https://doi.org/10.1016/B978-0-12-385065-2.00006-2">https://doi.org/10.1016/B978-0-12-385065-2.00006-2</a>
  chicago: Krens, Gabriel, and Carl-Philipp J Heisenberg. “Cell Sorting in Development.”
    In <i>Forces and Tension in Development</i>, edited by Michel Labouesse, 95:189–213.
    Elsevier, 2011. <a href="https://doi.org/10.1016/B978-0-12-385065-2.00006-2">https://doi.org/10.1016/B978-0-12-385065-2.00006-2</a>.
  ieee: G. Krens and C.-P. J. Heisenberg, “Cell sorting in development,” in <i>Forces
    and Tension in Development</i>, vol. 95, M. Labouesse, Ed. Elsevier, 2011, pp.
    189–213.
  ista: 'Krens G, Heisenberg C-PJ. 2011.Cell sorting in development. In: Forces and
    Tension in Development. Current Topics in Developmental Biology, vol. 95, 189–213.'
  mla: Krens, Gabriel, and Carl-Philipp J. Heisenberg. “Cell Sorting in Development.”
    <i>Forces and Tension in Development</i>, edited by Michel Labouesse, vol. 95,
    Elsevier, 2011, pp. 189–213, doi:<a href="https://doi.org/10.1016/B978-0-12-385065-2.00006-2">10.1016/B978-0-12-385065-2.00006-2</a>.
  short: G. Krens, C.-P.J. Heisenberg, in:, M. Labouesse (Ed.), Forces and Tension
    in Development, Elsevier, 2011, pp. 189–213.
date_created: 2018-12-11T12:05:11Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:13Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/B978-0-12-385065-2.00006-2
editor:
- first_name: Michel
  full_name: Labouesse, Michel
  last_name: Labouesse
intvolume: '        95'
language:
- iso: eng
month: '01'
oa_version: None
page: 189 - 213
publication: Forces and Tension in Development
publication_status: published
publisher: Elsevier
publist_id: '2436'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell sorting in development
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 95
year: '2011'
...
---
_id: '3796'
abstract:
- lang: eng
  text: We address the problem of covering ℝ n with congruent balls, while minimizing
    the number of balls that contain an average point. Considering the 1-parameter
    family of lattices defined by stretching or compressing the integer grid in diagonal
    direction, we give a closed formula for the covering density that depends on the
    distortion parameter. We observe that our family contains the thinnest lattice
    coverings in dimensions 2 to 5. We also consider the problem of packing congruent
    balls in ℝ n , for which we give a closed formula for the packing density as well.
    Again we observe that our family contains optimal configurations, this time densest
    packings in dimensions 2 and 3.
alternative_title:
- LNCS
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Michael
  full_name: Kerber, Michael
  id: 36E4574A-F248-11E8-B48F-1D18A9856A87
  last_name: Kerber
  orcid: 0000-0002-8030-9299
citation:
  ama: 'Edelsbrunner H, Kerber M. Covering and packing with spheres by diagonal distortion
    in R^n. In: Calude C, Rozenberg G, Salomaa A, eds. <i>Rainbow of Computer Science</i>.
    Vol 6570. Dedicated to Hermann Maurer on the Occasion of His 70th Birthday. Springer;
    2011:20-35. doi:<a href="https://doi.org/10.1007/978-3-642-19391-0_2">10.1007/978-3-642-19391-0_2</a>'
  apa: Edelsbrunner, H., &#38; Kerber, M. (2011). Covering and packing with spheres
    by diagonal distortion in R^n. In C. Calude, G. Rozenberg, &#38; A. Salomaa (Eds.),
    <i>Rainbow of Computer Science</i> (Vol. 6570, pp. 20–35). Springer. <a href="https://doi.org/10.1007/978-3-642-19391-0_2">https://doi.org/10.1007/978-3-642-19391-0_2</a>
  chicago: Edelsbrunner, Herbert, and Michael Kerber. “Covering and Packing with Spheres
    by Diagonal Distortion in R^n.” In <i>Rainbow of Computer Science</i>, edited
    by Cristian Calude, Grzegorz Rozenberg, and Arto Salomaa, 6570:20–35. Dedicated
    to Hermann Maurer on the Occasion of His 70th Birthday. Springer, 2011. <a href="https://doi.org/10.1007/978-3-642-19391-0_2">https://doi.org/10.1007/978-3-642-19391-0_2</a>.
  ieee: H. Edelsbrunner and M. Kerber, “Covering and packing with spheres by diagonal
    distortion in R^n,” in <i>Rainbow of Computer Science</i>, vol. 6570, C. Calude,
    G. Rozenberg, and A. Salomaa, Eds. Springer, 2011, pp. 20–35.
  ista: 'Edelsbrunner H, Kerber M. 2011.Covering and packing with spheres by diagonal
    distortion in R^n. In: Rainbow of Computer Science. LNCS, vol. 6570, 20–35.'
  mla: Edelsbrunner, Herbert, and Michael Kerber. “Covering and Packing with Spheres
    by Diagonal Distortion in R^n.” <i>Rainbow of Computer Science</i>, edited by
    Cristian Calude et al., vol. 6570, Springer, 2011, pp. 20–35, doi:<a href="https://doi.org/10.1007/978-3-642-19391-0_2">10.1007/978-3-642-19391-0_2</a>.
  short: H. Edelsbrunner, M. Kerber, in:, C. Calude, G. Rozenberg, A. Salomaa (Eds.),
    Rainbow of Computer Science, Springer, 2011, pp. 20–35.
date_created: 2018-12-11T12:05:13Z
date_published: 2011-05-03T00:00:00Z
date_updated: 2021-01-12T07:52:15Z
day: '03'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.1007/978-3-642-19391-0_2
editor:
- first_name: Cristian
  full_name: Calude, Cristian
  last_name: Calude
- first_name: Grzegorz
  full_name: Rozenberg, Grzegorz
  last_name: Rozenberg
- first_name: Arto
  full_name: Salomaa, Arto
  last_name: Salomaa
file:
- access_level: open_access
  checksum: aaf22b4d7bd4277ffe8db532119cf474
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:07:42Z
  date_updated: 2020-07-14T12:46:16Z
  file_id: '4640'
  file_name: IST-2016-539-v1+1_2011-B-01-CoveringPacking.pdf
  file_size: 436875
  relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
intvolume: '      6570'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 20 - 35
publication: Rainbow of Computer Science
publication_status: published
publisher: Springer
publist_id: '2427'
pubrep_id: '539'
quality_controlled: '1'
series_title: Dedicated to Hermann Maurer on the Occasion of His 70th Birthday
status: public
title: Covering and packing with spheres by diagonal distortion in R^n
type: book_chapter
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 6570
year: '2011'
...
---
_id: '3965'
abstract:
- lang: eng
  text: The elevation function on a smoothly embedded 2-manifold in R-3 reflects the
    multiscale topography of cavities and protrusions as local maxima. The function
    has been useful in identifying coarse docking configurations for protein pairs.
    Transporting the concept from the smooth to the piecewise linear category, this
    paper describes an algorithm for finding all local maxima. While its worst-case
    running time is the same as of the algorithm used in prior work, its performance
    in practice is orders of magnitudes superior. We cast light on this improvement
    by relating the running time to the total absolute Gaussian curvature of the 2-manifold.
author:
- first_name: Bei
  full_name: Wang, Bei
  last_name: Wang
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Dmitriy
  full_name: Morozov, Dmitriy
  last_name: Morozov
citation:
  ama: Wang B, Edelsbrunner H, Morozov D. Computing elevation maxima by searching
    the Gauss sphere. <i>Journal of Experimental Algorithmics</i>. 2011;16(2.2):1-13.
    doi:<a href="https://doi.org/10.1145/1963190.1970375">10.1145/1963190.1970375</a>
  apa: Wang, B., Edelsbrunner, H., &#38; Morozov, D. (2011). Computing elevation maxima
    by searching the Gauss sphere. <i>Journal of Experimental Algorithmics</i>. ACM.
    <a href="https://doi.org/10.1145/1963190.1970375">https://doi.org/10.1145/1963190.1970375</a>
  chicago: Wang, Bei, Herbert Edelsbrunner, and Dmitriy Morozov. “Computing Elevation
    Maxima by Searching the Gauss Sphere.” <i>Journal of Experimental Algorithmics</i>.
    ACM, 2011. <a href="https://doi.org/10.1145/1963190.1970375">https://doi.org/10.1145/1963190.1970375</a>.
  ieee: B. Wang, H. Edelsbrunner, and D. Morozov, “Computing elevation maxima by searching
    the Gauss sphere,” <i>Journal of Experimental Algorithmics</i>, vol. 16, no. 2.2.
    ACM, pp. 1–13, 2011.
  ista: Wang B, Edelsbrunner H, Morozov D. 2011. Computing elevation maxima by searching
    the Gauss sphere. Journal of Experimental Algorithmics. 16(2.2), 1–13.
  mla: Wang, Bei, et al. “Computing Elevation Maxima by Searching the Gauss Sphere.”
    <i>Journal of Experimental Algorithmics</i>, vol. 16, no. 2.2, ACM, 2011, pp.
    1–13, doi:<a href="https://doi.org/10.1145/1963190.1970375">10.1145/1963190.1970375</a>.
  short: B. Wang, H. Edelsbrunner, D. Morozov, Journal of Experimental Algorithmics
    16 (2011) 1–13.
date_created: 2018-12-11T12:06:09Z
date_published: 2011-05-01T00:00:00Z
date_updated: 2021-01-12T07:53:31Z
day: '01'
department:
- _id: HeEd
doi: 10.1145/1963190.1970375
intvolume: '        16'
issue: '2.2'
language:
- iso: eng
month: '05'
oa_version: None
page: 1 - 13
publication: Journal of Experimental Algorithmics
publication_status: published
publisher: ACM
publist_id: '2161'
quality_controlled: '1'
scopus_import: 1
status: public
title: Computing elevation maxima by searching the Gauss sphere
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2011'
...
---
_id: '3303'
abstract:
- lang: eng
  text: 'Biological traits result in part from interactions between different genetic
    loci. This can lead to sign epistasis, in which a beneficial adaptation involves
    a combination of individually deleterious or neutral mutations; in this case,
    a population must cross a “fitness valley” to adapt. Recombination can assist
    this process by combining mutations from different individuals or retard it by
    breaking up the adaptive combination. Here, we analyze the simplest fitness valley,
    in which an adaptation requires one mutation at each of two loci to provide a
    fitness benefit. We present a theoretical analysis of the effect of recombination
    on the valley-crossing process across the full spectrum of possible parameter
    regimes. We find that low recombination rates can speed up valley crossing relative
    to the asexual case, while higher recombination rates slow down valley crossing,
    with the transition between the two regimes occurring when the recombination rate
    between the loci is approximately equal to the selective advantage provided by
    the adaptation. In large populations, if the recombination rate is high and selection
    against single mutants is substantial, the time to cross the valley grows exponentially
    with population size, effectively meaning that the population cannot acquire the
    adaptation. Recombination at the optimal (low) rate can reduce the valley-crossing
    time by up to several orders of magnitude relative to that in an asexual population. '
acknowledgement: "This work was supported in part by a Robert N. Noyce Stanford Graduate
  Fellowship and European Research Council grant 250152 (to D.B.W.) and by National
  Institutes of Health grant GM 28016 (to M.W.F.).\r\nWe thank Michael Desai for many
  ideas and discussions and are grateful to Joanna Masel and an anonymous reviewer
  for their helpful suggestions. "
author:
- first_name: Daniel
  full_name: Weissman, Daniel
  id: 2D0CE020-F248-11E8-B48F-1D18A9856A87
  last_name: Weissman
- first_name: Marcus
  full_name: Feldman, Marcus
  last_name: Feldman
- first_name: Daniel
  full_name: Fisher, Daniel
  last_name: Fisher
citation:
  ama: Weissman D, Feldman M, Fisher D. The rate of fitness-valley crossing in sexual
    populations. <i>Genetics</i>. 2010;186(4):1389-1410. doi:<a href="https://doi.org/10.1534/genetics.110.123240">10.1534/genetics.110.123240</a>
  apa: Weissman, D., Feldman, M., &#38; Fisher, D. (2010). The rate of fitness-valley
    crossing in sexual populations. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1534/genetics.110.123240">https://doi.org/10.1534/genetics.110.123240</a>
  chicago: Weissman, Daniel, Marcus Feldman, and Daniel Fisher. “The Rate of Fitness-Valley
    Crossing in Sexual Populations.” <i>Genetics</i>. Genetics Society of America,
    2010. <a href="https://doi.org/10.1534/genetics.110.123240">https://doi.org/10.1534/genetics.110.123240</a>.
  ieee: D. Weissman, M. Feldman, and D. Fisher, “The rate of fitness-valley crossing
    in sexual populations,” <i>Genetics</i>, vol. 186, no. 4. Genetics Society of
    America, pp. 1389–1410, 2010.
  ista: Weissman D, Feldman M, Fisher D. 2010. The rate of fitness-valley crossing
    in sexual populations. Genetics. 186(4), 1389–1410.
  mla: Weissman, Daniel, et al. “The Rate of Fitness-Valley Crossing in Sexual Populations.”
    <i>Genetics</i>, vol. 186, no. 4, Genetics Society of America, 2010, pp. 1389–410,
    doi:<a href="https://doi.org/10.1534/genetics.110.123240">10.1534/genetics.110.123240</a>.
  short: D. Weissman, M. Feldman, D. Fisher, Genetics 186 (2010) 1389–1410.
date_created: 2018-12-11T12:02:33Z
date_published: 2010-12-01T00:00:00Z
date_updated: 2021-01-12T07:42:31Z
day: '01'
department:
- _id: NiBa
doi: 10.1534/genetics.110.123240
ec_funded: 1
intvolume: '       186'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998319/
month: '12'
oa: 1
oa_version: Submitted Version
page: 1389 - 1410
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '3337'
quality_controlled: '1'
scopus_import: 1
status: public
title: The rate of fitness-valley crossing in sexual populations
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 186
year: '2010'
...
---
_id: '10908'
abstract:
- lang: eng
  text: We present ABC, a software tool for automatically computing symbolic upper
    bounds on the number of iterations of nested program loops. The system combines
    static analysis of programs with symbolic summation techniques to derive loop
    invariant relations between program variables. Iteration bounds are obtained from
    the inferred invariants, by replacing variables with bounds on their greatest
    values. We have successfully applied ABC to a large number of examples. The derived
    symbolic bounds express non-trivial polynomial relations over loop variables.
    We also report on results to automatically infer symbolic expressions over harmonic
    numbers as upper bounds on loop iteration counts.
acknowledgement: This work was supported in part by the Swiss NSF. The fourth author
  is supported by an FWF Hertha Firnberg Research grant (T425-N23).
article_processing_charge: No
author:
- first_name: Régis
  full_name: Blanc, Régis
  last_name: Blanc
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Thibaud
  full_name: Hottelier, Thibaud
  last_name: Hottelier
- first_name: Laura
  full_name: Kovács, Laura
  last_name: Kovács
citation:
  ama: 'Blanc R, Henzinger TA, Hottelier T, Kovács L. ABC: Algebraic Bound Computation
    for loops. In: Clarke EM, Voronkov A, eds. <i>Logic for Programming, Artificial
    Intelligence, and Reasoning</i>. Vol 6355. LNCS. Berlin, Heidelberg: Springer
    Nature; 2010:103-118. doi:<a href="https://doi.org/10.1007/978-3-642-17511-4_7">10.1007/978-3-642-17511-4_7</a>'
  apa: 'Blanc, R., Henzinger, T. A., Hottelier, T., &#38; Kovács, L. (2010). ABC:
    Algebraic Bound Computation for loops. In E. M. Clarke &#38; A. Voronkov (Eds.),
    <i>Logic for Programming, Artificial Intelligence, and Reasoning</i> (Vol. 6355,
    pp. 103–118). Berlin, Heidelberg: Springer Nature. <a href="https://doi.org/10.1007/978-3-642-17511-4_7">https://doi.org/10.1007/978-3-642-17511-4_7</a>'
  chicago: 'Blanc, Régis, Thomas A Henzinger, Thibaud Hottelier, and Laura Kovács.
    “ABC: Algebraic Bound Computation for Loops.” In <i>Logic for Programming, Artificial
    Intelligence, and Reasoning</i>, edited by Edmund M Clarke and Andrei Voronkov,
    6355:103–18. LNCS. Berlin, Heidelberg: Springer Nature, 2010. <a href="https://doi.org/10.1007/978-3-642-17511-4_7">https://doi.org/10.1007/978-3-642-17511-4_7</a>.'
  ieee: 'R. Blanc, T. A. Henzinger, T. Hottelier, and L. Kovács, “ABC: Algebraic Bound
    Computation for loops,” in <i>Logic for Programming, Artificial Intelligence,
    and Reasoning</i>, Dakar, Senegal, 2010, vol. 6355, pp. 103–118.'
  ista: 'Blanc R, Henzinger TA, Hottelier T, Kovács L. 2010. ABC: Algebraic Bound
    Computation for loops. Logic for Programming, Artificial Intelligence, and Reasoning.
    LPAR: Conference on Logic for Programming, Artificial Intelligence and ReasoningLNCS
    vol. 6355, 103–118.'
  mla: 'Blanc, Régis, et al. “ABC: Algebraic Bound Computation for Loops.” <i>Logic
    for Programming, Artificial Intelligence, and Reasoning</i>, edited by Edmund
    M Clarke and Andrei Voronkov, vol. 6355, Springer Nature, 2010, pp. 103–18, doi:<a
    href="https://doi.org/10.1007/978-3-642-17511-4_7">10.1007/978-3-642-17511-4_7</a>.'
  short: R. Blanc, T.A. Henzinger, T. Hottelier, L. Kovács, in:, E.M. Clarke, A. Voronkov
    (Eds.), Logic for Programming, Artificial Intelligence, and Reasoning, Springer
    Nature, Berlin, Heidelberg, 2010, pp. 103–118.
conference:
  end_date: 2010-05-01
  location: Dakar, Senegal
  name: 'LPAR: Conference on Logic for Programming, Artificial Intelligence and Reasoning'
  start_date: 2010-04-25
date_created: 2022-03-21T08:14:35Z
date_published: 2010-05-01T00:00:00Z
date_updated: 2022-06-13T07:44:21Z
day: '01'
department:
- _id: ToHe
doi: 10.1007/978-3-642-17511-4_7
editor:
- first_name: Edmund M
  full_name: Clarke, Edmund M
  last_name: Clarke
- first_name: Andrei
  full_name: Voronkov, Andrei
  last_name: Voronkov
intvolume: '      6355'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://infoscience.epfl.ch/record/186096
month: '05'
oa: 1
oa_version: Submitted Version
page: 103-118
place: Berlin, Heidelberg
publication: Logic for Programming, Artificial Intelligence, and Reasoning
publication_identifier:
  eisbn:
  - '9783642175114'
  eissn:
  - 1611-3349
  isbn:
  - '9783642175107'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: 'ABC: Algebraic Bound Computation for loops'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6355
year: '2010'
...
---
_id: '10909'
abstract:
- lang: eng
  text: We address the problem of localizing homology classes, namely, finding the
    cycle representing a given class with the most concise geometric measure. We focus
    on the volume measure, that is, the 1-norm of a cycle. Two main results are presented.
    First, we prove the problem is NP-hard to approximate within any constant factor.
    Second, we prove that for homology of dimension two or higher, the problem is
    NP-hard to approximate even when the Betti number is O(1). A side effect is the
    inapproximability of the problem of computing the nonbounding cycle with the smallest
    volume, and computing cycles representing a homology basis with the minimal total
    volume. We also discuss other geometric measures (diameter and radius) and show
    their disadvantages in homology localization. Our work is restricted to homology
    over the ℤ2 field.
acknowledgement: Partially supported by the Austrian Science Fund under grantFSP-S9103-N04
  and P20134-N13.
article_processing_charge: No
author:
- first_name: Chao
  full_name: Chen, Chao
  id: 3E92416E-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Daniel
  full_name: Freedman, Daniel
  last_name: Freedman
citation:
  ama: 'Chen C, Freedman D. Hardness results for homology localization. In: <i>Proceedings
    of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Society for
    Industrial and Applied Mathematics; 2010:1594-1604. doi:<a href="https://doi.org/10.1137/1.9781611973075.129">10.1137/1.9781611973075.129</a>'
  apa: 'Chen, C., &#38; Freedman, D. (2010). Hardness results for homology localization.
    In <i>Proceedings of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms</i>
    (pp. 1594–1604). Austin, TX, United States: Society for Industrial and Applied
    Mathematics. <a href="https://doi.org/10.1137/1.9781611973075.129">https://doi.org/10.1137/1.9781611973075.129</a>'
  chicago: Chen, Chao, and Daniel Freedman. “Hardness Results for Homology Localization.”
    In <i>Proceedings of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms</i>,
    1594–1604. Society for Industrial and Applied Mathematics, 2010. <a href="https://doi.org/10.1137/1.9781611973075.129">https://doi.org/10.1137/1.9781611973075.129</a>.
  ieee: C. Chen and D. Freedman, “Hardness results for homology localization,” in
    <i>Proceedings of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms</i>,
    Austin, TX, United States, 2010, pp. 1594–1604.
  ista: 'Chen C, Freedman D. 2010. Hardness results for homology localization. Proceedings
    of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium
    on Discrete Algorithms, 1594–1604.'
  mla: Chen, Chao, and Daniel Freedman. “Hardness Results for Homology Localization.”
    <i>Proceedings of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms</i>,
    Society for Industrial and Applied Mathematics, 2010, pp. 1594–604, doi:<a href="https://doi.org/10.1137/1.9781611973075.129">10.1137/1.9781611973075.129</a>.
  short: C. Chen, D. Freedman, in:, Proceedings of the 2010 Annual ACM-SIAM Symposium
    on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2010,
    pp. 1594–1604.
conference:
  end_date: 2010-01-19
  location: Austin, TX, United States
  name: 'SODA: Symposium on Discrete Algorithms'
  start_date: 2010-01-17
date_created: 2022-03-21T08:24:07Z
date_published: 2010-02-01T00:00:00Z
date_updated: 2023-02-23T11:19:46Z
day: '01'
department:
- _id: HeEd
doi: 10.1137/1.9781611973075.129
language:
- iso: eng
month: '02'
oa_version: None
page: 1594-1604
publication: Proceedings of the 2010 Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
  eisbn:
  - '9781611973075'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
  record:
  - id: '3267'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Hardness results for homology localization
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2010'
...
---
_id: '2409'
abstract:
- lang: eng
  text: "Background: The availability of many gene alignments with overlapping taxon
    sets raises the question of which strategy is the best to infer species phylogenies
    from multiple gene information. Methods and programs abound that use the gene
    alignment in different ways to reconstruct the species tree. In particular, different
    methods combine the original data at different points along the way from the underlying
    sequences to the final tree. Accordingly, they are classified into superalignment,
    supertree and medium-level approaches. Here, we present a simulation study to
    compare different methods from each of these three approaches.\r\n\r\nResults:
    We observe that superalignment methods usually outperform the other approaches
    over a wide range of parameters including sparse data and gene-specific evolutionary
    parameters. In the presence of high incongruency among gene trees, however, other
    combination methods show better performance than the superalignment approach.
    Surprisingly, some supertree and medium-level methods exhibit, on average, worse
    results than a single gene phylogeny with complete taxon information.\r\n\r\nConclusions:
    For some methods, using the reconstructed gene tree as an estimation of the species
    tree is superior to the combination of incomplete information. Superalignment
    usually performs best since it is less susceptible to stochastic error. Supertree
    methods can outperform superalignment in the presence of gene-tree conflict."
acknowledgement: Financial support from the Wiener Wissenschafts-, Forschungs- and
  Technologiefonds (WWTF) is greatly appreciated. A.v.H. acknowledges support from
  the German Research Foundation (DFG, SPP-1174).
article_number: '37'
author:
- first_name: Anne
  full_name: Kupczok, Anne
  id: 2BB22BC2-F248-11E8-B48F-1D18A9856A87
  last_name: Kupczok
- first_name: Heiko
  full_name: Schmidt, Heiko
  last_name: Schmidt
- first_name: Arndt
  full_name: Von Haeseler, Arndt
  last_name: Von Haeseler
citation:
  ama: Kupczok A, Schmidt H, Von Haeseler A. Accuracy of phylogeny reconstruction
    methods combining overlapping gene data sets . <i>Algorithms for Molecular Biology</i>.
    2010;5(1). doi:<a href="https://doi.org/10.1186/1748-7188-5-37">10.1186/1748-7188-5-37</a>
  apa: Kupczok, A., Schmidt, H., &#38; Von Haeseler, A. (2010). Accuracy of phylogeny
    reconstruction methods combining overlapping gene data sets . <i>Algorithms for
    Molecular Biology</i>. BioMed Central. <a href="https://doi.org/10.1186/1748-7188-5-37">https://doi.org/10.1186/1748-7188-5-37</a>
  chicago: Kupczok, Anne, Heiko Schmidt, and Arndt Von Haeseler. “Accuracy of Phylogeny
    Reconstruction Methods Combining Overlapping Gene Data Sets .” <i>Algorithms for
    Molecular Biology</i>. BioMed Central, 2010. <a href="https://doi.org/10.1186/1748-7188-5-37">https://doi.org/10.1186/1748-7188-5-37</a>.
  ieee: A. Kupczok, H. Schmidt, and A. Von Haeseler, “Accuracy of phylogeny reconstruction
    methods combining overlapping gene data sets ,” <i>Algorithms for Molecular Biology</i>,
    vol. 5, no. 1. BioMed Central, 2010.
  ista: Kupczok A, Schmidt H, Von Haeseler A. 2010. Accuracy of phylogeny reconstruction
    methods combining overlapping gene data sets . Algorithms for Molecular Biology.
    5(1), 37.
  mla: Kupczok, Anne, et al. “Accuracy of Phylogeny Reconstruction Methods Combining
    Overlapping Gene Data Sets .” <i>Algorithms for Molecular Biology</i>, vol. 5,
    no. 1, 37, BioMed Central, 2010, doi:<a href="https://doi.org/10.1186/1748-7188-5-37">10.1186/1748-7188-5-37</a>.
  short: A. Kupczok, H. Schmidt, A. Von Haeseler, Algorithms for Molecular Biology
    5 (2010).
date_created: 2018-12-11T11:57:30Z
date_published: 2010-12-06T00:00:00Z
date_updated: 2021-01-12T06:57:18Z
day: '06'
ddc:
- '576'
department:
- _id: JoBo
doi: 10.1186/1748-7188-5-37
file:
- access_level: open_access
  checksum: e2497285388bc4da629bafb46662eb43
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:16Z
  date_updated: 2020-07-14T12:45:40Z
  file_id: '4739'
  file_name: IST-2018-939-v1+1_2010_Kupczok_Accuracy_of.pdf
  file_size: 723929
  relation: main_file
file_date_updated: 2020-07-14T12:45:40Z
has_accepted_license: '1'
intvolume: '         5'
issue: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Algorithms for Molecular Biology
publication_status: published
publisher: BioMed Central
publist_id: '4517'
pubrep_id: '939'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Accuracy of phylogeny reconstruction methods combining overlapping gene data
  sets '
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2010'
...
---
_id: '474'
abstract:
- lang: eng
  text: 'Classical models of gene flow fail in three ways: they cannot explain large-scale
    patterns; they predict much more genetic diversity than is observed; and they
    assume that loosely linked genetic loci evolve independently. We propose a new
    model that deals with these problems. Extinction events kill some fraction of
    individuals in a region. These are replaced by offspring from a small number of
    parents, drawn from the preexisting population. This model of evolution forwards
    in time corresponds to a backwards model, in which ancestral lineages jump to
    a new location if they are hit by an event, and may coalesce with other lineages
    that are hit by the same event. We derive an expression for the identity in allelic
    state, and show that, over scales much larger than the largest event, this converges
    to the classical value derived by Wright and Malécot. However, rare events that
    cover large areas cause low genetic diversity, large-scale patterns, and correlations
    in ancestry between unlinked loci.'
acknowledgement: This work has made use of the resources provided by the Edinburgh
  Compute and Data Facility (ECDF). The ECDF is partially supported by the eDIKT initiative.
  NHB is supported in part by EPSRC Grant EP/E066070/1; JK is supported by EPSRC Grant
  EP/E066070/1; and AME is supported in part by EPSRC Grant EP/E065945/1.
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Jerome
  full_name: Kelleher, Jerome
  last_name: Kelleher
- first_name: Alison
  full_name: Etheridge, Alison
  last_name: Etheridge
citation:
  ama: 'Barton NH, Kelleher J, Etheridge A. A new model for extinction and recolonization
    in two dimensions: Quantifying phylogeography. <i>Evolution</i>. 2010;64(9):2701-2715.
    doi:<a href="https://doi.org/10.1111/j.1558-5646.2010.01019.x">10.1111/j.1558-5646.2010.01019.x</a>'
  apa: 'Barton, N. H., Kelleher, J., &#38; Etheridge, A. (2010). A new model for extinction
    and recolonization in two dimensions: Quantifying phylogeography. <i>Evolution</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1558-5646.2010.01019.x">https://doi.org/10.1111/j.1558-5646.2010.01019.x</a>'
  chicago: 'Barton, Nicholas H, Jerome Kelleher, and Alison Etheridge. “A New Model
    for Extinction and Recolonization in Two Dimensions: Quantifying Phylogeography.”
    <i>Evolution</i>. Wiley-Blackwell, 2010. <a href="https://doi.org/10.1111/j.1558-5646.2010.01019.x">https://doi.org/10.1111/j.1558-5646.2010.01019.x</a>.'
  ieee: 'N. H. Barton, J. Kelleher, and A. Etheridge, “A new model for extinction
    and recolonization in two dimensions: Quantifying phylogeography,” <i>Evolution</i>,
    vol. 64, no. 9. Wiley-Blackwell, pp. 2701–2715, 2010.'
  ista: 'Barton NH, Kelleher J, Etheridge A. 2010. A new model for extinction and
    recolonization in two dimensions: Quantifying phylogeography. Evolution. 64(9),
    2701–2715.'
  mla: 'Barton, Nicholas H., et al. “A New Model for Extinction and Recolonization
    in Two Dimensions: Quantifying Phylogeography.” <i>Evolution</i>, vol. 64, no.
    9, Wiley-Blackwell, 2010, pp. 2701–15, doi:<a href="https://doi.org/10.1111/j.1558-5646.2010.01019.x">10.1111/j.1558-5646.2010.01019.x</a>.'
  short: N.H. Barton, J. Kelleher, A. Etheridge, Evolution 64 (2010) 2701–2715.
date_created: 2018-12-11T11:46:40Z
date_published: 2010-09-01T00:00:00Z
date_updated: 2021-01-12T08:00:52Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/j.1558-5646.2010.01019.x
intvolume: '        64'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 2701 - 2715
publication: Evolution
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2780'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'A new model for extinction and recolonization in two dimensions: Quantifying
  phylogeography'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 64
year: '2010'
...
---
_id: '488'
abstract:
- lang: eng
  text: 'Streaming string transducers [1] define (partial) functions from input strings
    to output strings. A streaming string transducer makes a single pass through the
    input string and uses a finite set of variables that range over strings from the
    output alphabet. At every step, the transducer processes an input symbol, and
    updates all the variables in parallel using assignments whose right-hand-sides
    are concatenations of output symbols and variables with the restriction that a
    variable can be used at most once in a right-hand-side expression. It has been
    shown that streaming string transducers operating on strings over infinite data
    domains are of interest in algorithmic verification of list-processing programs,
    as they lead to PSPACE decision procedures for checking pre/post conditions and
    for checking semantic equivalence, for a well-defined class of heap-manipulating
    programs. In order to understand the theoretical expressiveness of streaming transducers,
    we focus on streaming transducers processing strings over finite alphabets, given
    the existence of a robust and well-studied class of &quot;regular&quot; transductions
    for this case. Such regular transductions can be defined either by two-way deterministic
    finite-state transducers, or using a logical MSO-based characterization. Our main
    result is that the expressiveness of streaming string transducers coincides exactly
    with this class of regular transductions. '
alternative_title:
- LIPIcs
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Pavol
  full_name: Cerny, Pavol
  id: 4DCBEFFE-F248-11E8-B48F-1D18A9856A87
  last_name: Cerny
citation:
  ama: 'Alur R, Cerny P. Expressiveness of streaming string transducers. In: Vol 8.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2010:1-12. doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2010.1">10.4230/LIPIcs.FSTTCS.2010.1</a>'
  apa: 'Alur, R., &#38; Cerny, P. (2010). Expressiveness of streaming string transducers
    (Vol. 8, pp. 1–12). Presented at the FSTTCS: Foundations of Software Technology
    and Theoretical Computer Science, Chennai, India: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2010.1">https://doi.org/10.4230/LIPIcs.FSTTCS.2010.1</a>'
  chicago: Alur, Rajeev, and Pavol Cerny. “Expressiveness of Streaming String Transducers,”
    8:1–12. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2010. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2010.1">https://doi.org/10.4230/LIPIcs.FSTTCS.2010.1</a>.
  ieee: 'R. Alur and P. Cerny, “Expressiveness of streaming string transducers,” presented
    at the FSTTCS: Foundations of Software Technology and Theoretical Computer Science,
    Chennai, India, 2010, vol. 8, pp. 1–12.'
  ista: 'Alur R, Cerny P. 2010. Expressiveness of streaming string transducers. FSTTCS:
    Foundations of Software Technology and Theoretical Computer Science, LIPIcs, vol.
    8, 1–12.'
  mla: Alur, Rajeev, and Pavol Cerny. <i>Expressiveness of Streaming String Transducers</i>.
    Vol. 8, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2010, pp. 1–12, doi:<a
    href="https://doi.org/10.4230/LIPIcs.FSTTCS.2010.1">10.4230/LIPIcs.FSTTCS.2010.1</a>.
  short: R. Alur, P. Cerny, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2010, pp. 1–12.
conference:
  end_date: 2010-12-18
  location: Chennai, India
  name: 'FSTTCS: Foundations of Software Technology and Theoretical Computer Science'
  start_date: 2010-12-15
date_created: 2018-12-11T11:46:45Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T08:01:00Z
day: '01'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.4230/LIPIcs.FSTTCS.2010.1
file:
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  checksum: 5845be5aa19791830f7407d8853f2df0
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  creator: system
  date_created: 2018-12-12T10:08:29Z
  date_updated: 2020-07-14T12:46:35Z
  file_id: '4690'
  file_name: IST-2018-948-v1+1_2011_Cerny_Expressiveness_of.pdf
  file_size: 492344
  relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: '         8'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '01'
oa: 1
oa_version: Published Version
page: 1 - 12
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7331'
pubrep_id: '948'
quality_controlled: '1'
scopus_import: 1
status: public
title: Expressiveness of streaming string transducers
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2010'
...
