---
_id: '3129'
abstract:
- lang: eng
text: "Let K be a simplicial complex and g the rank of its p-th homology group Hp(K)
defined with ℤ2 coefficients. We show that we can compute a basis H of Hp(K) and
annotate each p-simplex of K with a binary vector of length g with the following
property: the annotations, summed over all p-simplices in any p-cycle z, provide
the coordinate vector of the homology class [z] in the basis H. The basis and
the annotations for all simplices can be computed in O(n ω ) time, where n is
the size of K and ω < 2.376 is a quantity so that two n×n matrices can be multiplied
in O(n ω ) time. The precomputed annotations permit answering queries about the
independence or the triviality of p-cycles efficiently.\r\n\r\nUsing annotations
of edges in 2-complexes, we derive better algorithms for computing optimal basis
and optimal homologous cycles in 1 - dimensional homology. Specifically, for computing
an optimal basis of H1(K) , we improve the previously known time complexity from
O(n 4) to O(n ω + n 2 g ω − 1). Here n denotes the size of the 2-skeleton of
K and g the rank of H1(K) . Computing an optimal cycle homologous to a given 1-cycle
is NP-hard even for surfaces and an algorithm taking 2 O(g) nlogn time is known
for surfaces. We extend this algorithm to work with arbitrary 2-complexes in O(n
ω ) + 2 O(g) n 2logn time using annotations.\r\n"
alternative_title:
- LNCS
arxiv: 1
author:
- first_name: Oleksiy
full_name: Busaryev, Oleksiy
last_name: Busaryev
- first_name: Sergio
full_name: Cabello, Sergio
last_name: Cabello
- first_name: Chao
full_name: Chen, Chao
id: 3E92416E-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Yusu
full_name: Wang, Yusu
last_name: Wang
citation:
ama: 'Busaryev O, Cabello S, Chen C, Dey T, Wang Y. Annotating simplices with a
homology basis and its applications. In: Vol 7357. Springer; 2012:189-200. doi:10.1007/978-3-642-31155-0_17'
apa: 'Busaryev, O., Cabello, S., Chen, C., Dey, T., & Wang, Y. (2012). Annotating
simplices with a homology basis and its applications (Vol. 7357, pp. 189–200).
Presented at the SWAT: Symposium and Workshops on Algorithm Theory, Helsinki,
Finland: Springer. https://doi.org/10.1007/978-3-642-31155-0_17'
chicago: Busaryev, Oleksiy, Sergio Cabello, Chao Chen, Tamal Dey, and Yusu Wang.
“Annotating Simplices with a Homology Basis and Its Applications,” 7357:189–200.
Springer, 2012. https://doi.org/10.1007/978-3-642-31155-0_17.
ieee: 'O. Busaryev, S. Cabello, C. Chen, T. Dey, and Y. Wang, “Annotating simplices
with a homology basis and its applications,” presented at the SWAT: Symposium
and Workshops on Algorithm Theory, Helsinki, Finland, 2012, vol. 7357, pp. 189–200.'
ista: 'Busaryev O, Cabello S, Chen C, Dey T, Wang Y. 2012. Annotating simplices
with a homology basis and its applications. SWAT: Symposium and Workshops on Algorithm
Theory, LNCS, vol. 7357, 189–200.'
mla: Busaryev, Oleksiy, et al. Annotating Simplices with a Homology Basis and
Its Applications. Vol. 7357, Springer, 2012, pp. 189–200, doi:10.1007/978-3-642-31155-0_17.
short: O. Busaryev, S. Cabello, C. Chen, T. Dey, Y. Wang, in:, Springer, 2012, pp.
189–200.
conference:
end_date: 2012-07-06
location: Helsinki, Finland
name: 'SWAT: Symposium and Workshops on Algorithm Theory'
start_date: 2012-07-04
date_created: 2018-12-11T12:01:33Z
date_published: 2012-06-19T00:00:00Z
date_updated: 2021-01-12T07:41:15Z
day: '19'
department:
- _id: HeEd
doi: 10.1007/978-3-642-31155-0_17
external_id:
arxiv:
- '1107.3793'
intvolume: ' 7357'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1107.3793
month: '06'
oa: 1
oa_version: Preprint
page: 189 - 200
publication_status: published
publisher: Springer
publist_id: '3569'
quality_controlled: '1'
scopus_import: 1
status: public
title: Annotating simplices with a homology basis and its applications
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7357
year: '2012'
...
---
_id: '3130'
abstract:
- lang: eng
text: 'Essential genes code for fundamental cellular functions required for the
viability of an organism. For this reason, essential genes are often highly conserved
across organisms. However, this is not always the case: orthologues of genes that
are essential in one organism are sometimes not essential in other organisms or
are absent from their genomes. This suggests that, in the course of evolution,
essential genes can be rendered nonessential. How can a gene become non-essential?
Here we used genetic manipulation to deplete the products of 26 different essential
genes in Escherichia coli. This depletion results in a lethal phenotype, which
could often be rescued by the overexpression of a non-homologous, non-essential
gene, most likely through replacement of the essential function. We also show
that, in a smaller number of cases, the essential genes can be fully deleted from
the genome, suggesting that complete functional replacement is possible. Finally,
we show that essential genes whose function can be replaced in the laboratory
are more likely to be non-essential or not present in other taxa. These results
are consistent with the notion that patterns of evolutionary conservation of essential
genes are influenced by their compensability-that is, by how easily they can be
functionally replaced, for example through increased expression of other genes.'
acknowledgement: We thank Alex Boehm for discussions and comments.
article_number: e1002803
author:
- first_name: Tobias
full_name: Bergmiller, Tobias
id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
last_name: Bergmiller
orcid: 0000-0001-5396-4346
- first_name: Martin
full_name: Ackermann, Martin
last_name: Ackermann
- first_name: Olin
full_name: Silander, Olin
last_name: Silander
citation:
ama: Bergmiller T, Ackermann M, Silander O. Patterns of evolutionary conservation
of essential genes correlate with their compensability. PLoS Genetics.
2012;8(6). doi:10.1371/journal.pgen.1002803
apa: Bergmiller, T., Ackermann, M., & Silander, O. (2012). Patterns of evolutionary
conservation of essential genes correlate with their compensability. PLoS Genetics.
Public Library of Science. https://doi.org/10.1371/journal.pgen.1002803
chicago: Bergmiller, Tobias, Martin Ackermann, and Olin Silander. “Patterns of Evolutionary
Conservation of Essential Genes Correlate with Their Compensability.” PLoS
Genetics. Public Library of Science, 2012. https://doi.org/10.1371/journal.pgen.1002803.
ieee: T. Bergmiller, M. Ackermann, and O. Silander, “Patterns of evolutionary conservation
of essential genes correlate with their compensability,” PLoS Genetics,
vol. 8, no. 6. Public Library of Science, 2012.
ista: Bergmiller T, Ackermann M, Silander O. 2012. Patterns of evolutionary conservation
of essential genes correlate with their compensability. PLoS Genetics. 8(6), e1002803.
mla: Bergmiller, Tobias, et al. “Patterns of Evolutionary Conservation of Essential
Genes Correlate with Their Compensability.” PLoS Genetics, vol. 8, no.
6, e1002803, Public Library of Science, 2012, doi:10.1371/journal.pgen.1002803.
short: T. Bergmiller, M. Ackermann, O. Silander, PLoS Genetics 8 (2012).
date_created: 2018-12-11T12:01:34Z
date_published: 2012-06-28T00:00:00Z
date_updated: 2021-01-12T07:41:16Z
day: '28'
ddc:
- '576'
department:
- _id: CaGu
doi: 10.1371/journal.pgen.1002803
file:
- access_level: open_access
checksum: f8506fb579eda6fc5613ba9bf421b86a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:52Z
date_updated: 2020-07-14T12:46:01Z
file_id: '4973'
file_name: IST-2015-386-v1+1_journal.pgen.1002803.pdf
file_size: 2674138
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '3567'
pubrep_id: '386'
quality_controlled: '1'
scopus_import: 1
status: public
title: Patterns of evolutionary conservation of essential genes correlate with their
compensability
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2012'
...
---
_id: '3131'
abstract:
- lang: eng
text: 'In large populations, many beneficial mutations may be simultaneously available
and may compete with one another, slowing adaptation. By finding the probability
of fixation of a favorable allele in a simple model of a haploid sexual population,
we find limits to the rate of adaptive substitution, Λ, that depend on simple
parameter combinations. When variance in fitness is low and linkage is loose,
the baseline rate of substitution is Λ 0=2NU〈s〉 is the population size, U is the
rate of beneficial mutations per genome, and 〈s〉 is their mean selective advantage.
Heritable variance ν in log fitness due to unlinked loci reduces Λ by e -4ν under
polygamy and e -8ν under monogamy. With a linear genetic map of length R Morgans,
interference is yet stronger. We use a scaling argument to show that the density
of adaptive substitutions depends on s, N, U, and R only through the baseline
density: Λ/R=F(Λ 0/R). Under the approximation that the interference due to different
sweeps adds up, we show that Λ/R~(Λ 0/R)/(1+2Λ 0/R), implying that interference
prevents the rate of adaptive substitution from exceeding one per centimorgan
per 200 generations. Simulations and numerical calculations confirm the scaling
argument and confirm the additive approximation for Λ 0/R 1; for higher Λ 0/R,
the rate of adaptation grows above R/2, but only very slowly. We also consider
the effect of sweeps on neutral diversity and show that, while even occasional
sweeps can greatly reduce neutral diversity, this effect saturates as sweeps become
more common-diversity can be maintained even in populations experiencing very
strong interference. Our results indicate that for some organisms the rate of
adaptive substitution may be primarily recombination-limited, depending only weakly
on the mutation supply and the strength of selection.'
acknowledgement: "The work was funded by ERC grant 250152.\r\nWe thank B. Charlesworth,
O. Hallatschek, W. G. Hill, R. A. Neher, S. P. Otto, and the anonymous reviewers
for their helpful suggestions."
article_number: e1002740
author:
- first_name: Daniel
full_name: Weissman, Daniel
id: 2D0CE020-F248-11E8-B48F-1D18A9856A87
last_name: Weissman
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Weissman D, Barton NH. Limits to the rate of adaptive substitution in sexual
populations. PLoS Genetics. 2012;8(6). doi:10.1371/journal.pgen.1002740
apa: Weissman, D., & Barton, N. H. (2012). Limits to the rate of adaptive substitution
in sexual populations. PLoS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1002740
chicago: Weissman, Daniel, and Nicholas H Barton. “Limits to the Rate of Adaptive
Substitution in Sexual Populations.” PLoS Genetics. Public Library of Science,
2012. https://doi.org/10.1371/journal.pgen.1002740.
ieee: D. Weissman and N. H. Barton, “Limits to the rate of adaptive substitution
in sexual populations,” PLoS Genetics, vol. 8, no. 6. Public Library of
Science, 2012.
ista: Weissman D, Barton NH. 2012. Limits to the rate of adaptive substitution in
sexual populations. PLoS Genetics. 8(6), e1002740.
mla: Weissman, Daniel, and Nicholas H. Barton. “Limits to the Rate of Adaptive Substitution
in Sexual Populations.” PLoS Genetics, vol. 8, no. 6, e1002740, Public
Library of Science, 2012, doi:10.1371/journal.pgen.1002740.
short: D. Weissman, N.H. Barton, PLoS Genetics 8 (2012).
date_created: 2018-12-11T12:01:34Z
date_published: 2012-06-07T00:00:00Z
date_updated: 2021-01-12T07:41:17Z
day: '07'
ddc:
- '570'
- '576'
department:
- _id: NiBa
doi: 10.1371/journal.pgen.1002740
ec_funded: 1
file:
- access_level: open_access
checksum: 729a4becda7d786c4c3db8f9a1f77953
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:00Z
date_updated: 2020-07-14T12:46:01Z
file_id: '4659'
file_name: IST-2013-114-v1+1_WeissmanBarton2012.pdf
file_size: 1284801
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '3566'
pubrep_id: '114'
quality_controlled: '1'
scopus_import: 1
status: public
title: Limits to the rate of adaptive substitution in sexual populations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2012'
...
---
_id: '3132'
abstract:
- lang: eng
text: 'Reproductive division of labour is a characteristic trait of social insects.
The dominant reproductive individual, often the queen, uses chemical communication
and/or behaviour to maintain her social status. Queens of many social insects
communicate their fertility status via cuticle-bound substances. As these substances
usually possess a low volatility, their range in queen–worker communication is
potentially limited. Here, we investigate the range and impact of behavioural
and chemical queen signals on workers of the ant Temnothorax longispinosus. We
compared the behaviour and ovary development of workers subjected to three different
treatments: workers with direct chemical and physical contact to the queen, those
solely under the influence of volatile queen substances and those entirely separated
from the queen. In addition to short-ranged queen signals preventing ovary development
in workers, we discovered a novel secondary pathway influencing worker behaviour.
Workers with no physical contact to the queen, but exposed to volatile substances,
started to develop their ovaries, but did not change their behaviour compared
to workers in direct contact to the queen. In contrast, workers in queen-separated
groups showed both increased ovary development and aggressive dominance interactions.
We conclude that T. longispinosus queens influence worker ovary development and
behaviour via two independent signals, both ensuring social harmony within the
colony.'
acknowledgement: We like to thank the editor and three anonymous reviewers for their
time and constructive criticism and Inon Scharf, Volker Witte and Andreas Modlmeier
for helpful comments on earlier versions of the manuscript. The first and second
authors appear in alphabetical order and contributed equally to this paper.
author:
- first_name: Matthias
full_name: Konrad, Matthias
id: 46528076-F248-11E8-B48F-1D18A9856A87
last_name: Konrad
- first_name: Tobias
full_name: Pamminger, Tobias
last_name: Pamminger
- first_name: Susanne
full_name: Foitzik, Susanne
last_name: Foitzik
citation:
ama: Konrad M, Pamminger T, Foitzik S. Two pathways ensuring social harmony. Naturwissenschaften.
2012;99(8):627-636. doi:10.1007/s00114-012-0943-z
apa: Konrad, M., Pamminger, T., & Foitzik, S. (2012). Two pathways ensuring
social harmony. Naturwissenschaften. Springer. https://doi.org/10.1007/s00114-012-0943-z
chicago: Konrad, Matthias, Tobias Pamminger, and Susanne Foitzik. “Two Pathways
Ensuring Social Harmony.” Naturwissenschaften. Springer, 2012. https://doi.org/10.1007/s00114-012-0943-z.
ieee: M. Konrad, T. Pamminger, and S. Foitzik, “Two pathways ensuring social harmony,”
Naturwissenschaften, vol. 99, no. 8. Springer, pp. 627–636, 2012.
ista: Konrad M, Pamminger T, Foitzik S. 2012. Two pathways ensuring social harmony.
Naturwissenschaften. 99(8), 627–636.
mla: Konrad, Matthias, et al. “Two Pathways Ensuring Social Harmony.” Naturwissenschaften,
vol. 99, no. 8, Springer, 2012, pp. 627–36, doi:10.1007/s00114-012-0943-z.
short: M. Konrad, T. Pamminger, S. Foitzik, Naturwissenschaften 99 (2012) 627–636.
date_created: 2018-12-11T12:01:34Z
date_published: 2012-08-01T00:00:00Z
date_updated: 2021-01-12T07:41:17Z
day: '01'
department:
- _id: SyCr
doi: 10.1007/s00114-012-0943-z
intvolume: ' 99'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 627 - 636
publication: Naturwissenschaften
publication_status: published
publisher: Springer
publist_id: '3565'
quality_controlled: '1'
scopus_import: 1
status: public
title: Two pathways ensuring social harmony
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2012'
...
---
_id: '3133'
abstract:
- lang: eng
text: 'This note contributes to the point calculus of persistent homology by extending
Alexander duality from spaces to real-valued functions. Given a perfect Morse
function f: S n+1 →[0, 1 and a decomposition S n+1 = U ∪ V into two (n + 1)-manifolds
with common boundary M, we prove elementary relationships between the persistence
diagrams of f restricted to U, to V, and to M. '
acknowledgement: "his research is partially supported by the National Science Foundation
(NSF) under grant DBI-0820624, the European Science Foundation under the Research
Networking Programme, and the Russian Government Project 11.G34.31.0053.\r\nThe
authors thank an anonymous referee for suggesting the simplified proof of the Contravariant
PE Theorem given in this paper. They also thank Frederick Cohen, Yuriy Mileyko and
Amit Patel for helpful discussions."
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Kerber, Michael
id: 36E4574A-F248-11E8-B48F-1D18A9856A87
last_name: Kerber
orcid: 0000-0002-8030-9299
citation:
ama: 'Edelsbrunner H, Kerber M. Alexander duality for functions: The persistent
behavior of land and water and shore. In: Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry . ACM; 2012:249-258. doi:10.1145/2261250.2261287'
apa: 'Edelsbrunner, H., & Kerber, M. (2012). Alexander duality for functions:
The persistent behavior of land and water and shore. In Proceedings of the
twenty-eighth annual symposium on Computational geometry (pp. 249–258). Chapel
Hill, NC, USA: ACM. https://doi.org/10.1145/2261250.2261287'
chicago: 'Edelsbrunner, Herbert, and Michael Kerber. “Alexander Duality for Functions:
The Persistent Behavior of Land and Water and Shore.” In Proceedings of the
Twenty-Eighth Annual Symposium on Computational Geometry , 249–58. ACM, 2012.
https://doi.org/10.1145/2261250.2261287.'
ieee: 'H. Edelsbrunner and M. Kerber, “Alexander duality for functions: The persistent
behavior of land and water and shore,” in Proceedings of the twenty-eighth
annual symposium on Computational geometry , Chapel Hill, NC, USA, 2012, pp.
249–258.'
ista: 'Edelsbrunner H, Kerber M. 2012. Alexander duality for functions: The persistent
behavior of land and water and shore. Proceedings of the twenty-eighth annual
symposium on Computational geometry . SCG: Symposium on Computational Geometry,
249–258.'
mla: 'Edelsbrunner, Herbert, and Michael Kerber. “Alexander Duality for Functions:
The Persistent Behavior of Land and Water and Shore.” Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry , ACM, 2012, pp. 249–58, doi:10.1145/2261250.2261287.'
short: H. Edelsbrunner, M. Kerber, in:, Proceedings of the Twenty-Eighth Annual
Symposium on Computational Geometry , ACM, 2012, pp. 249–258.
conference:
end_date: 2012-06-20
location: Chapel Hill, NC, USA
name: 'SCG: Symposium on Computational Geometry'
start_date: 2012-06-17
date_created: 2018-12-11T12:01:35Z
date_published: 2012-06-20T00:00:00Z
date_updated: 2021-01-12T07:41:17Z
day: '20'
department:
- _id: HeEd
doi: 10.1145/2261250.2261287
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1109.5052
month: '06'
oa: 1
oa_version: Preprint
page: 249 - 258
publication: 'Proceedings of the twenty-eighth annual symposium on Computational geometry '
publication_status: published
publisher: ACM
publist_id: '3564'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Alexander duality for functions: The persistent behavior of land and water
and shore'
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '3134'
abstract:
- lang: eng
text: 'It has been an open question whether the sum of finitely many isotropic Gaussian
kernels in n ≥ 2 dimensions can have more modes than kernels, until in 2003 Carreira-Perpiñán
and Williams exhibited n +1 isotropic Gaussian kernels in ℝ n with n + 2 modes.
We give a detailed analysis of this example, showing that it has exponentially
many critical points and that the resilience of the extra mode grows like √n.
In addition, we exhibit finite configurations of isotropic Gaussian kernels with
superlinearly many modes. '
acknowledgement: This research is partially supported by the National Science Foun-
dation (NSF) under grant DBI-0820624, by the European Science Foundation under the
Research Networking Programme, and the Russian Government Project 11.G34.31.0053.
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Brittany
full_name: Fasy, Brittany
last_name: Fasy
- first_name: Günter
full_name: Rote, Günter
last_name: Rote
citation:
ama: 'Edelsbrunner H, Fasy B, Rote G. Add isotropic Gaussian kernels at own risk:
More and more resilient modes in higher dimensions. In: Proceedings of the
Twenty-Eighth Annual Symposium on Computational Geometry . ACM; 2012:91-100.
doi:10.1145/2261250.2261265'
apa: 'Edelsbrunner, H., Fasy, B., & Rote, G. (2012). Add isotropic Gaussian
kernels at own risk: More and more resilient modes in higher dimensions. In Proceedings
of the twenty-eighth annual symposium on Computational geometry (pp. 91–100).
Chapel Hill, NC, USA: ACM. https://doi.org/10.1145/2261250.2261265'
chicago: 'Edelsbrunner, Herbert, Brittany Fasy, and Günter Rote. “Add Isotropic
Gaussian Kernels at Own Risk: More and More Resilient Modes in Higher Dimensions.”
In Proceedings of the Twenty-Eighth Annual Symposium on Computational Geometry
, 91–100. ACM, 2012. https://doi.org/10.1145/2261250.2261265.'
ieee: 'H. Edelsbrunner, B. Fasy, and G. Rote, “Add isotropic Gaussian kernels at
own risk: More and more resilient modes in higher dimensions,” in Proceedings
of the twenty-eighth annual symposium on Computational geometry , Chapel Hill,
NC, USA, 2012, pp. 91–100.'
ista: 'Edelsbrunner H, Fasy B, Rote G. 2012. Add isotropic Gaussian kernels at own
risk: More and more resilient modes in higher dimensions. Proceedings of the twenty-eighth
annual symposium on Computational geometry . SCG: Symposium on Computational Geometry,
91–100.'
mla: 'Edelsbrunner, Herbert, et al. “Add Isotropic Gaussian Kernels at Own Risk:
More and More Resilient Modes in Higher Dimensions.” Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry , ACM, 2012, pp. 91–100, doi:10.1145/2261250.2261265.'
short: H. Edelsbrunner, B. Fasy, G. Rote, in:, Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry , ACM, 2012, pp. 91–100.
conference:
end_date: 2012-06-20
location: Chapel Hill, NC, USA
name: 'SCG: Symposium on Computational Geometry'
start_date: 2012-06-17
date_created: 2018-12-11T12:01:35Z
date_published: 2012-06-20T00:00:00Z
date_updated: 2023-02-23T10:59:27Z
day: '20'
department:
- _id: HeEd
doi: 10.1145/2261250.2261265
language:
- iso: eng
month: '06'
oa_version: None
page: 91 - 100
publication: 'Proceedings of the twenty-eighth annual symposium on Computational geometry '
publication_status: published
publisher: ACM
publist_id: '3563'
quality_controlled: '1'
related_material:
record:
- id: '2815'
relation: later_version
status: public
scopus_import: 1
status: public
title: 'Add isotropic Gaussian kernels at own risk: More and more resilient modes
in higher dimensions'
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '3135'
abstract:
- lang: eng
text: 'We introduce consumption games, a model for discrete interactive system with
multiple resources that are consumed or reloaded independently. More precisely,
a consumption game is a finite-state graph where each transition is labeled by
a vector of resource updates, where every update is a non-positive number or ω.
The ω updates model the reloading of a given resource. Each vertex belongs either
to player □ or player ◇, where the aim of player □ is to play so that the resources
are never exhausted. We consider several natural algorithmic problems about consumption
games, and show that although these problems are computationally hard in general,
they are solvable in polynomial time for every fixed number of resource types
(i.e., the dimension of the update vectors) and bounded resource updates. '
acknowledgement: 'Tomas Brazdil, Antonin Kucera, and Petr Novotny are supported by
the Czech Science Foundation, grant No. P202/10/1469. Krishnendu Chatterjee is supported
by the FWF (Austrian Science Fund) NFN Grant No S11407-N23 (RiSE) and ERC Start
grant (279307: Graph Games).'
alternative_title:
- LNCS
author:
- first_name: Brázdil
full_name: Brázdil, Brázdil
last_name: Brázdil
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Antonín
full_name: Kučera, Antonín
last_name: Kučera
- first_name: Petr
full_name: Novotny, Petr
id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
last_name: Novotny
citation:
ama: 'Brázdil B, Chatterjee K, Kučera A, Novotný P. Efficient controller synthesis
for consumption games with multiple resource types. In: Vol 7358. Springer; 2012:23-38.
doi:10.1007/978-3-642-31424-7_8'
apa: 'Brázdil, B., Chatterjee, K., Kučera, A., & Novotný, P. (2012). Efficient
controller synthesis for consumption games with multiple resource types (Vol.
7358, pp. 23–38). Presented at the CAV: Computer Aided Verification, Berkeley,
CA, USA: Springer. https://doi.org/10.1007/978-3-642-31424-7_8'
chicago: Brázdil, Brázdil, Krishnendu Chatterjee, Antonín Kučera, and Petr Novotný.
“Efficient Controller Synthesis for Consumption Games with Multiple Resource Types,”
7358:23–38. Springer, 2012. https://doi.org/10.1007/978-3-642-31424-7_8.
ieee: 'B. Brázdil, K. Chatterjee, A. Kučera, and P. Novotný, “Efficient controller
synthesis for consumption games with multiple resource types,” presented at the
CAV: Computer Aided Verification, Berkeley, CA, USA, 2012, vol. 7358, pp. 23–38.'
ista: 'Brázdil B, Chatterjee K, Kučera A, Novotný P. 2012. Efficient controller
synthesis for consumption games with multiple resource types. CAV: Computer Aided
Verification, LNCS, vol. 7358, 23–38.'
mla: Brázdil, Brázdil, et al. Efficient Controller Synthesis for Consumption
Games with Multiple Resource Types. Vol. 7358, Springer, 2012, pp. 23–38,
doi:10.1007/978-3-642-31424-7_8.
short: B. Brázdil, K. Chatterjee, A. Kučera, P. Novotný, in:, Springer, 2012, pp.
23–38.
conference:
end_date: 2012-07-13
location: Berkeley, CA, USA
name: 'CAV: Computer Aided Verification'
start_date: 2012-07-07
date_created: 2018-12-11T12:01:35Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T07:41:18Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-642-31424-7_8
ec_funded: 1
intvolume: ' 7358'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1202.0796
month: '07'
oa: 1
oa_version: Preprint
page: 23 - 38
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '3562'
quality_controlled: '1'
scopus_import: 1
status: public
title: Efficient controller synthesis for consumption games with multiple resource
types
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7358
year: '2012'
...
---
_id: '3136'
abstract:
- lang: eng
text: 'Continuous-time Markov chains (CTMC) with their rich theory and efficient
simulation algorithms have been successfully used in modeling stochastic processes
in diverse areas such as computer science, physics, and biology. However, systems
that comprise non-instantaneous events cannot be accurately and efficiently modeled
with CTMCs. In this paper we define delayed CTMCs, an extension of CTMCs that
allows for the specification of a lower bound on the time interval between an
event''s initiation and its completion, and we propose an algorithm for the computation
of their behavior. Our algorithm effectively decomposes the computation into two
stages: a pure CTMC governs event initiations while a deterministic process guarantees
lower bounds on event completion times. Furthermore, from the nature of delayed
CTMCs, we obtain a parallelized version of our algorithm. We use our formalism
to model genetic regulatory circuits (biological systems where delayed events
are common) and report on the results of our numerical algorithm as run on a cluster.
We compare performance and accuracy of our results with results obtained by using
pure CTMCs. © 2012 Springer-Verlag.'
acknowledgement: This work was supported by the ERC Advanced Investigator grant on
Quantitative Reactive Modeling (QUAREM) and by the Swiss National Science Foundation.
alternative_title:
- LNCS
author:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Ashutosh
full_name: Gupta, Ashutosh
id: 335E5684-F248-11E8-B48F-1D18A9856A87
last_name: Gupta
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Maria
full_name: Mateescu, Maria
id: 3B43276C-F248-11E8-B48F-1D18A9856A87
last_name: Mateescu
- first_name: Ali
full_name: Sezgin, Ali
id: 4C7638DA-F248-11E8-B48F-1D18A9856A87
last_name: Sezgin
citation:
ama: 'Guet CC, Gupta A, Henzinger TA, Mateescu M, Sezgin A. Delayed continuous time
Markov chains for genetic regulatory circuits. In: Vol 7358. Springer; 2012:294-309.
doi:10.1007/978-3-642-31424-7_24'
apa: 'Guet, C. C., Gupta, A., Henzinger, T. A., Mateescu, M., & Sezgin, A. (2012).
Delayed continuous time Markov chains for genetic regulatory circuits (Vol. 7358,
pp. 294–309). Presented at the CAV: Computer Aided Verification, Berkeley, CA,
USA: Springer. https://doi.org/10.1007/978-3-642-31424-7_24'
chicago: Guet, Calin C, Ashutosh Gupta, Thomas A Henzinger, Maria Mateescu, and
Ali Sezgin. “Delayed Continuous Time Markov Chains for Genetic Regulatory Circuits,”
7358:294–309. Springer, 2012. https://doi.org/10.1007/978-3-642-31424-7_24.
ieee: 'C. C. Guet, A. Gupta, T. A. Henzinger, M. Mateescu, and A. Sezgin, “Delayed
continuous time Markov chains for genetic regulatory circuits,” presented at the
CAV: Computer Aided Verification, Berkeley, CA, USA, 2012, vol. 7358, pp. 294–309.'
ista: 'Guet CC, Gupta A, Henzinger TA, Mateescu M, Sezgin A. 2012. Delayed continuous
time Markov chains for genetic regulatory circuits. CAV: Computer Aided Verification,
LNCS, vol. 7358, 294–309.'
mla: Guet, Calin C., et al. Delayed Continuous Time Markov Chains for Genetic
Regulatory Circuits. Vol. 7358, Springer, 2012, pp. 294–309, doi:10.1007/978-3-642-31424-7_24.
short: C.C. Guet, A. Gupta, T.A. Henzinger, M. Mateescu, A. Sezgin, in:, Springer,
2012, pp. 294–309.
conference:
end_date: 2012-07-13
location: Berkeley, CA, USA
name: 'CAV: Computer Aided Verification'
start_date: 2012-07-07
date_created: 2018-12-11T12:01:36Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T07:41:18Z
day: '01'
department:
- _id: CaGu
- _id: ToHe
doi: 10.1007/978-3-642-31424-7_24
ec_funded: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 294 - 309
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
publication_status: published
publisher: Springer
publist_id: '3561'
quality_controlled: '1'
scopus_import: 1
status: public
title: Delayed continuous time Markov chains for genetic regulatory circuits
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: '7358 '
year: '2012'
...
---
_id: '3155'
abstract:
- lang: eng
text: 'We propose synchronous interfaces, a new interface theory for discrete-time
systems. We use an application to time-triggered scheduling to drive the design
choices for our formalism; in particular, additionally to deriving useful mathematical
properties, we focus on providing a syntax which is adapted to natural high-level
system modeling. As a result, we develop an interface model that relies on a guarded-command
based language and is equipped with shared variables and explicit discrete-time
clocks. We define all standard interface operations: compatibility checking, composition,
refinement, and shared refinement. Apart from the synchronous interface model,
the contribution of this paper is the establishment of a formal relation between
interface theories and real-time scheduling, where we demonstrate a fully automatic
framework for the incremental computation of time-triggered schedules.'
acknowledgement: Research partially supported by the Danish-Chinese Center for Cyber
Physical Systems (Grant No.61061130541) and VKR Center of Excellence MT-LAB.
alternative_title:
- LNCS
author:
- first_name: Benoît
full_name: Delahaye, Benoît
last_name: Delahaye
- first_name: Uli
full_name: Fahrenberg, Uli
last_name: Fahrenberg
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Axel
full_name: Legay, Axel
last_name: Legay
- first_name: Dejan
full_name: Nickovic, Dejan
id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87
last_name: Nickovic
citation:
ama: 'Delahaye B, Fahrenberg U, Henzinger TA, Legay A, Nickovic D. Synchronous interface
theories and time triggered scheduling. In: Vol 7273. Springer; 2012:203-218.
doi:10.1007/978-3-642-30793-5_13'
apa: 'Delahaye, B., Fahrenberg, U., Henzinger, T. A., Legay, A., & Nickovic,
D. (2012). Synchronous interface theories and time triggered scheduling (Vol.
7273, pp. 203–218). Presented at the FORTE: Formal Techniques for Networked and
Distributed Systems & FMOODS: Formal Methods for Open Object-Based Distributed
Systems , Stockholm, Sweden: Springer. https://doi.org/10.1007/978-3-642-30793-5_13'
chicago: Delahaye, Benoît, Uli Fahrenberg, Thomas A Henzinger, Axel Legay, and Dejan
Nickovic. “Synchronous Interface Theories and Time Triggered Scheduling,” 7273:203–18.
Springer, 2012. https://doi.org/10.1007/978-3-642-30793-5_13.
ieee: 'B. Delahaye, U. Fahrenberg, T. A. Henzinger, A. Legay, and D. Nickovic, “Synchronous
interface theories and time triggered scheduling,” presented at the FORTE: Formal
Techniques for Networked and Distributed Systems & FMOODS: Formal Methods
for Open Object-Based Distributed Systems , Stockholm, Sweden, 2012, vol. 7273,
pp. 203–218.'
ista: 'Delahaye B, Fahrenberg U, Henzinger TA, Legay A, Nickovic D. 2012. Synchronous
interface theories and time triggered scheduling. FORTE: Formal Techniques for
Networked and Distributed Systems & FMOODS: Formal Methods for Open Object-Based
Distributed Systems , LNCS, vol. 7273, 203–218.'
mla: Delahaye, Benoît, et al. Synchronous Interface Theories and Time Triggered
Scheduling. Vol. 7273, Springer, 2012, pp. 203–18, doi:10.1007/978-3-642-30793-5_13.
short: B. Delahaye, U. Fahrenberg, T.A. Henzinger, A. Legay, D. Nickovic, in:, Springer,
2012, pp. 203–218.
conference:
end_date: 2012-06-16
location: Stockholm, Sweden
name: 'FORTE: Formal Techniques for Networked and Distributed Systems & FMOODS:
Formal Methods for Open Object-Based Distributed Systems '
start_date: 2012-06-13
date_created: 2018-12-11T12:01:43Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T07:41:26Z
day: '01'
ddc:
- '004'
department:
- _id: ToHe
doi: 10.1007/978-3-642-30793-5_13
file:
- access_level: open_access
checksum: feae2e07f2d9a59843f8ddabf25d179f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:25Z
date_updated: 2020-07-14T12:46:01Z
file_id: '4879'
file_name: IST-2012-88-v1+1_Synchronous_interface_theories_and_time_triggered_scheduling.pdf
file_size: 493198
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 7273'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 203 - 218
publication_status: published
publisher: Springer
publist_id: '3539'
pubrep_id: '88'
quality_controlled: '1'
scopus_import: 1
status: public
title: Synchronous interface theories and time triggered scheduling
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7273
year: '2012'
...
---
_id: '3156'
abstract:
- lang: eng
text: Dispersal is crucial for gene flow and often determines the long-term stability
of meta-populations, particularly in rare species with specialized life cycles.
Such species are often foci of conservation efforts because they suffer disproportionally
from degradation and fragmentation of their habitat. However, detailed knowledge
of effective gene flow through dispersal is often missing, so that conservation
strategies have to be based on mark-recapture observations that are suspected
to be poor predictors of long-distance dispersal. These constraints have been
especially severe in the study of butterfly populations, where microsatellite
markers have been difficult to develop. We used eight microsatellite markers to
analyse genetic population structure of the Large Blue butterfly Maculinea arion
in Sweden. During recent decades, this species has become an icon of insect conservation
after massive decline throughout Europe and extinction in Britain followed by
reintroduction of a seed population from the Swedish island of Öland. We find
that populations are highly structured genetically, but that gene flow occurs
over distances 15 times longer than the maximum distance recorded from mark-recapture
studies, which can only be explained by maximum dispersal distances at least twice
as large as previously accepted. However, we also find evidence that gaps between
sites with suitable habitat exceeding ∼ 20 km induce genetic erosion that can
be detected from bottleneck analyses. Although further work is needed, our results
suggest that M. arion can maintain fully functional metapopulations when they
consist of optimal habitat patches that are no further apart than ∼10 km.
acknowledgement: "The work was financed by the Danish National Science Research Foundation
via a grant to the Centre for Social Evolution.\r\nWe thank four anonymous reviewers
for useful comments on the manuscript, J. Bergsten, P. Bina, B. Carlsson, M. Johannesson
and A.E. Lomborg for providing additional wingtip samples, A. Illum for assistance
in the field, and in particular P.S. Nielsen for mediating the contact to the collectors
and the Swedish authorities. Collection was made possible through a permit by the
Åtgärdsprogrammet, supported by the Swedish Environmental Protection Agency."
author:
- first_name: Line V
full_name: Ugelvig, Line V
id: 3DC97C8E-F248-11E8-B48F-1D18A9856A87
last_name: Ugelvig
orcid: 0000-0003-1832-8883
- first_name: Anne
full_name: Andersen, Anne
last_name: Andersen
- first_name: Jacobus
full_name: Boomsma, Jacobus
last_name: Boomsma
- first_name: David
full_name: Nash, David
last_name: Nash
citation:
ama: Ugelvig LV, Andersen A, Boomsma J, Nash D. Dispersal and gene flow in the rare
parasitic Large Blue butterfly Maculinea arion. Molecular Ecology. 2012;21(13):3224-3236.
doi:10.1111/j.1365-294X.2012.05592.x
apa: Ugelvig, L. V., Andersen, A., Boomsma, J., & Nash, D. (2012). Dispersal
and gene flow in the rare parasitic Large Blue butterfly Maculinea arion. Molecular
Ecology. Wiley-Blackwell. https://doi.org/10.1111/j.1365-294X.2012.05592.x
chicago: Ugelvig, Line V, Anne Andersen, Jacobus Boomsma, and David Nash. “Dispersal
and Gene Flow in the Rare Parasitic Large Blue Butterfly Maculinea Arion.” Molecular
Ecology. Wiley-Blackwell, 2012. https://doi.org/10.1111/j.1365-294X.2012.05592.x.
ieee: L. V. Ugelvig, A. Andersen, J. Boomsma, and D. Nash, “Dispersal and gene flow
in the rare parasitic Large Blue butterfly Maculinea arion,” Molecular Ecology,
vol. 21, no. 13. Wiley-Blackwell, pp. 3224–3236, 2012.
ista: Ugelvig LV, Andersen A, Boomsma J, Nash D. 2012. Dispersal and gene flow in
the rare parasitic Large Blue butterfly Maculinea arion. Molecular Ecology. 21(13),
3224–3236.
mla: Ugelvig, Line V., et al. “Dispersal and Gene Flow in the Rare Parasitic Large
Blue Butterfly Maculinea Arion.” Molecular Ecology, vol. 21, no. 13, Wiley-Blackwell,
2012, pp. 3224–36, doi:10.1111/j.1365-294X.2012.05592.x.
short: L.V. Ugelvig, A. Andersen, J. Boomsma, D. Nash, Molecular Ecology 21 (2012)
3224–3236.
date_created: 2018-12-11T12:01:43Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T07:41:27Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/j.1365-294X.2012.05592.x
intvolume: ' 21'
issue: '13'
language:
- iso: eng
month: '07'
oa_version: None
page: 3224 - 3236
publication: Molecular Ecology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3538'
quality_controlled: '1'
scopus_import: 1
status: public
title: Dispersal and gene flow in the rare parasitic Large Blue butterfly Maculinea
arion
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2012'
...
---
_id: '3157'
abstract:
- lang: eng
text: Colorectal tumours that are wild type for KRAS are often sensitive to EGFR
blockade, but almost always develop resistance within several months of initiating
therapy. The mechanisms underlying this acquired resistance to anti-EGFR antibodies
are largely unknown. This situation is in marked contrast to that of small-molecule
targeted agents, such as inhibitors of ABL, EGFR, BRAF and MEK, in which mutations
in the genes encoding the protein targets render the tumours resistant to the
effects of the drugs. The simplest hypothesis to account for the development of
resistance to EGFR blockade is that rare cells with KRAS mutations pre-exist at
low levels in tumours with ostensibly wild-type KRAS genes. Although this hypothesis
would seem readily testable, there is no evidence in pre-clinical models to support
it, nor is there data from patients. To test this hypothesis, we determined whether
mutant KRAS DNA could be detected in the circulation of 28 patients receiving
monotherapy with panitumumab, a therapeutic anti-EGFR antibody. We found that
9 out of 24 (38%) patients whose tumours were initially KRAS wild type developed
detectable mutations in KRAS in their sera, three of which developed multiple
different KRAS mutations. The appearance of these mutations was very consistent,
generally occurring between 5 and 6months following treatment. Mathematical modelling
indicated that the mutations were present in expanded subclones before the initiation
of panitumumab treatment. These results suggest that the emergence of KRAS mutations
is a mediator of acquired resistance to EGFR blockade and that these mutations
can be detected in a non-invasive manner. They explain why solid tumours develop
resistance to targeted therapies in a highly reproducible fashion.
author:
- first_name: Luis
full_name: Diaz Jr, Luis
last_name: Diaz Jr
- first_name: Richard
full_name: Williams, Richard
last_name: Williams
- first_name: Jian
full_name: Wu, Jian
last_name: Wu
- first_name: Isaac
full_name: Kinde, Isaac
last_name: Kinde
- first_name: Joel
full_name: Hecht, Joel
last_name: Hecht
- first_name: Jordan
full_name: Berlin, Jordan
last_name: Berlin
- first_name: Benjamin
full_name: Allen, Benjamin
last_name: Allen
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
- first_name: Kenneth
full_name: Kinzler, Kenneth
last_name: Kinzler
- first_name: Kelly
full_name: Oliner, Kelly
last_name: Oliner
- first_name: Bert
full_name: Vogelstein, Bert
last_name: Vogelstein
citation:
ama: Diaz Jr L, Williams R, Wu J, et al. The molecular evolution of acquired resistance
to targeted EGFR blockade in colorectal cancers. Nature. 2012;486(7404):537-540.
doi:10.1038/nature11219
apa: Diaz Jr, L., Williams, R., Wu, J., Kinde, I., Hecht, J., Berlin, J., … Vogelstein,
B. (2012). The molecular evolution of acquired resistance to targeted EGFR blockade
in colorectal cancers. Nature. Nature Publishing Group. https://doi.org/10.1038/nature11219
chicago: Diaz Jr, Luis, Richard Williams, Jian Wu, Isaac Kinde, Joel Hecht, Jordan
Berlin, Benjamin Allen, et al. “The Molecular Evolution of Acquired Resistance
to Targeted EGFR Blockade in Colorectal Cancers.” Nature. Nature Publishing
Group, 2012. https://doi.org/10.1038/nature11219.
ieee: L. Diaz Jr et al., “The molecular evolution of acquired resistance
to targeted EGFR blockade in colorectal cancers,” Nature, vol. 486, no.
7404. Nature Publishing Group, pp. 537–540, 2012.
ista: Diaz Jr L, Williams R, Wu J, Kinde I, Hecht J, Berlin J, Allen B, Božić I,
Reiter J, Nowak M, Kinzler K, Oliner K, Vogelstein B. 2012. The molecular evolution
of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature.
486(7404), 537–540.
mla: Diaz Jr, Luis, et al. “The Molecular Evolution of Acquired Resistance to Targeted
EGFR Blockade in Colorectal Cancers.” Nature, vol. 486, no. 7404, Nature
Publishing Group, 2012, pp. 537–40, doi:10.1038/nature11219.
short: L. Diaz Jr, R. Williams, J. Wu, I. Kinde, J. Hecht, J. Berlin, B. Allen,
I. Božić, J. Reiter, M. Nowak, K. Kinzler, K. Oliner, B. Vogelstein, Nature 486
(2012) 537–540.
date_created: 2018-12-11T12:01:43Z
date_published: 2012-06-28T00:00:00Z
date_updated: 2023-09-07T11:40:43Z
day: '28'
department:
- _id: KrCh
doi: 10.1038/nature11219
ec_funded: 1
external_id:
pmid:
- '22722843'
intvolume: ' 486'
issue: '7404'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436069/
month: '06'
oa: 1
oa_version: Submitted Version
page: 537 - 540
pmid: 1
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '3537'
quality_controlled: '1'
related_material:
record:
- id: '1400'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: The molecular evolution of acquired resistance to targeted EGFR blockade in
colorectal cancers
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 486
year: '2012'
...
---
_id: '3158'
abstract:
- lang: eng
text: We describe here the development and characterization of a conditionally inducible
mouse model expressing Lifeact-GFP, a peptide that reports the dynamics of filamentous
actin. We have used this model to study platelets, megakaryocytes and melanoblasts
and we provide evidence that Lifeact-GFP is a useful reporter in these cell types
ex vivo. In the case of platelets and megakaryocytes, these cells are not transfectable
by traditional methods, so conditional activation of Lifeact allows the study
of actin dynamics in these cells live. We studied melanoblasts in native skin
explants from embryos, allowing the visualization of live actin dynamics during
cytokinesis and migration. Our study revealed that melanoblasts lacking the small
GTPase Rac1 show a delay in the formation of new pseudopodia following cytokinesis
that accounts for the previously reported cytokinesis delay in these cells. Thus,
through use of this mouse model, we were able to gain insights into the actin
dynamics of cells that could only previously be studied using fixed specimens
or following isolation from their native tissue environment.
author:
- first_name: Hannah
full_name: Schachtner, Hannah
last_name: Schachtner
- first_name: Ang
full_name: Li, Ang
last_name: Li
- first_name: David
full_name: Stevenson, David
last_name: Stevenson
- first_name: Simon
full_name: Calaminus, Simon
last_name: Calaminus
- first_name: Steven
full_name: Thomas, Steven
last_name: Thomas
- first_name: Steve
full_name: Watson, Steve
last_name: Watson
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Roland
full_name: Wedlich Söldner, Roland
last_name: Wedlich Söldner
- first_name: Douglas
full_name: Strathdee, Douglas
last_name: Strathdee
- first_name: Laura
full_name: Machesky, Laura
last_name: Machesky
citation:
ama: Schachtner H, Li A, Stevenson D, et al. Tissue inducible Lifeact expression
allows visualization of actin dynamics in vivo and ex vivo. European Journal
of Cell Biology. 2012;91(11-12):923-929. doi:10.1016/j.ejcb.2012.04.002
apa: Schachtner, H., Li, A., Stevenson, D., Calaminus, S., Thomas, S., Watson, S.,
… Machesky, L. (2012). Tissue inducible Lifeact expression allows visualization
of actin dynamics in vivo and ex vivo. European Journal of Cell Biology.
Elsevier. https://doi.org/10.1016/j.ejcb.2012.04.002
chicago: Schachtner, Hannah, Ang Li, David Stevenson, Simon Calaminus, Steven Thomas,
Steve Watson, Michael K Sixt, Roland Wedlich Söldner, Douglas Strathdee, and Laura
Machesky. “Tissue Inducible Lifeact Expression Allows Visualization of Actin Dynamics
in Vivo and Ex Vivo.” European Journal of Cell Biology. Elsevier, 2012.
https://doi.org/10.1016/j.ejcb.2012.04.002.
ieee: H. Schachtner et al., “Tissue inducible Lifeact expression allows visualization
of actin dynamics in vivo and ex vivo,” European Journal of Cell Biology,
vol. 91, no. 11–12. Elsevier, pp. 923–929, 2012.
ista: Schachtner H, Li A, Stevenson D, Calaminus S, Thomas S, Watson S, Sixt MK,
Wedlich Söldner R, Strathdee D, Machesky L. 2012. Tissue inducible Lifeact expression
allows visualization of actin dynamics in vivo and ex vivo. European Journal of
Cell Biology. 91(11–12), 923–929.
mla: Schachtner, Hannah, et al. “Tissue Inducible Lifeact Expression Allows Visualization
of Actin Dynamics in Vivo and Ex Vivo.” European Journal of Cell Biology,
vol. 91, no. 11–12, Elsevier, 2012, pp. 923–29, doi:10.1016/j.ejcb.2012.04.002.
short: H. Schachtner, A. Li, D. Stevenson, S. Calaminus, S. Thomas, S. Watson, M.K.
Sixt, R. Wedlich Söldner, D. Strathdee, L. Machesky, European Journal of Cell
Biology 91 (2012) 923–929.
date_created: 2018-12-11T12:01:44Z
date_published: 2012-11-01T00:00:00Z
date_updated: 2021-01-12T07:41:27Z
day: '01'
department:
- _id: MiSi
doi: 10.1016/j.ejcb.2012.04.002
external_id:
pmid:
- '22658956'
intvolume: ' 91'
issue: 11-12
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930012/
month: '11'
oa: 1
oa_version: Submitted Version
page: 923 - 929
pmid: 1
publication: European Journal of Cell Biology
publication_status: published
publisher: Elsevier
publist_id: '3534'
quality_controlled: '1'
scopus_import: 1
status: public
title: Tissue inducible Lifeact expression allows visualization of actin dynamics
in vivo and ex vivo
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 91
year: '2012'
...
---
_id: '3159'
abstract:
- lang: eng
text: The structure of hierarchical networks in biological and physical systems
has long been characterized using the Horton-Strahler ordering scheme. The scheme
assigns an integer order to each edge in the network based on the topology of
branching such that the order increases from distal parts of the network (e.g.,
mountain streams or capillaries) to the "root" of the network (e.g.,
the river outlet or the aorta). However, Horton-Strahler ordering cannot be applied
to networks with loops because they they create a contradiction in the edge ordering
in terms of which edge precedes another in the hierarchy. Here, we present a generalization
of the Horton-Strahler order to weighted planar reticular networks, where weights
are assumed to correlate with the importance of network edges, e.g., weights estimated
from edge widths may correlate to flow capacity. Our method assigns hierarchical
levels not only to edges of the network, but also to its loops, and classifies
the edges into reticular edges, which are responsible for loop formation, and
tree edges. In addition, we perform a detailed and rigorous theoretical analysis
of the sensitivity of the hierarchical levels to weight perturbations. In doing
so, we show that the ordering of the reticular edges is more robust to noise in
weight estimation than is the ordering of the tree edges. We discuss applications
of this generalized Horton-Strahler ordering to the study of leaf venation and
other biological networks.
acknowledgement: "his work was supported by the National Science Foundation Plant
Genome Research Program (grant 0820624 to H.E. and J.S.W.), the Defense Advanced
Projects Research Agency (grant HR0011-09-1-0055 to H.E. and J.S.W.), and the European
Science Foundation (under the Research Networking Programme on “Applied and Computational
Algebraic Topology” run by H.E.). Joshua S. Weitz, Ph.D., holds a Career Award at
the Scientific Interface from the Burroughs Wellcome Fund.\r\n\r\n\r\n\r\nDuring
preparation of this manuscript the authors became aware of a related work by Katifori
and Magnasco (arXiv:1110.1412v1), concurrently submitted and accepted for publication
in PLoS ONE."
article_number: e36715
author:
- first_name: Yuriy
full_name: Mileyko, Yuriy
last_name: Mileyko
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Charles
full_name: Price, Charles
last_name: Price
- first_name: Joshua
full_name: Weitz, Joshua
last_name: Weitz
citation:
ama: Mileyko Y, Edelsbrunner H, Price C, Weitz J. Hierarchical ordering of reticular
networks. PLoS One. 2012;7(6). doi:10.1371/journal.pone.0036715
apa: Mileyko, Y., Edelsbrunner, H., Price, C., & Weitz, J. (2012). Hierarchical
ordering of reticular networks. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0036715
chicago: Mileyko, Yuriy, Herbert Edelsbrunner, Charles Price, and Joshua Weitz.
“Hierarchical Ordering of Reticular Networks.” PLoS One. Public Library
of Science, 2012. https://doi.org/10.1371/journal.pone.0036715.
ieee: Y. Mileyko, H. Edelsbrunner, C. Price, and J. Weitz, “Hierarchical ordering
of reticular networks,” PLoS One, vol. 7, no. 6. Public Library of Science,
2012.
ista: Mileyko Y, Edelsbrunner H, Price C, Weitz J. 2012. Hierarchical ordering of
reticular networks. PLoS One. 7(6), e36715.
mla: Mileyko, Yuriy, et al. “Hierarchical Ordering of Reticular Networks.” PLoS
One, vol. 7, no. 6, e36715, Public Library of Science, 2012, doi:10.1371/journal.pone.0036715.
short: Y. Mileyko, H. Edelsbrunner, C. Price, J. Weitz, PLoS One 7 (2012).
date_created: 2018-12-11T12:01:44Z
date_published: 2012-06-06T00:00:00Z
date_updated: 2021-01-12T07:41:28Z
day: '06'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1371/journal.pone.0036715
file:
- access_level: open_access
checksum: 515a98ad72e470752f03f13663dcaff8
content_type: application/pdf
creator: kschuh
date_created: 2019-02-05T12:38:43Z
date_updated: 2020-07-14T12:46:01Z
file_id: '5922'
file_name: 2012_PLoS_Mileyko.PDF
file_size: 541583
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 7'
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3530'
pubrep_id: '385'
quality_controlled: '1'
scopus_import: 1
status: public
title: Hierarchical ordering of reticular networks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2012'
...
---
_id: '3160'
abstract:
- lang: eng
text: There is a long-running controversy about how early cell fate decisions are
made in the developing mammalian embryo. 1,2 In particular, it is controversial
when the first events that can predict the establishment of the pluripotent and
extra-embryonic lineages in the blastocyst of the pre-implantation embryo occur.
It has long been proposed that the position and polarity of cells at the 16- to
32-cell stage embryo influence their decision to either give rise to the pluripotent
cell lineage that eventually contributes to the inner cell mass (ICM), comprising
the primitive endoderm (PE) and the epiblast (EPI), or the extra-embryonic trophectoderm
(TE) surrounding the blastocoel. The positioning of cells in the embryo at this
developmental stage could largely be the result of random events, making this
a stochastic model of cell lineage allocation. Contrary to such a stochastic model,
some studies have detected putative differences in the lineage potential of individual
blastomeres before compaction, indicating that the first cell fate decisions may
occur as early as at the 4-cell stage. Using a non-invasive, quantitative in vivo
imaging assay to study the kinetic behavior of Oct4 (also known as POU5F1), a
key transcription factor (TF) controlling pre-implantation development in the
mouse embryo, 3-5 a recent study identifies Oct4 kinetics as a predictive measure
of cell lineage patterning in the early mouse embryo. 6 Here, we discuss the implications
of such molecular heterogeneities in early development and offer potential avenues
toward a mechanistic understanding of these observations, contributing to the
resolution of the controversy of developmental cell lineage allocation.
author:
- first_name: Periklis
full_name: Pantazis, Periklis
last_name: Pantazis
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
citation:
ama: Pantazis P, Bollenbach MT. Transcription factor kinetics and the emerging asymmetry
in the early mammalian embryo. Cell Cycle. 2012;11(11):2055-2058. doi:10.4161/cc.20118
apa: Pantazis, P., & Bollenbach, M. T. (2012). Transcription factor kinetics
and the emerging asymmetry in the early mammalian embryo. Cell Cycle. Taylor
and Francis. https://doi.org/10.4161/cc.20118
chicago: Pantazis, Periklis, and Mark Tobias Bollenbach. “Transcription Factor Kinetics
and the Emerging Asymmetry in the Early Mammalian Embryo.” Cell Cycle.
Taylor and Francis, 2012. https://doi.org/10.4161/cc.20118.
ieee: P. Pantazis and M. T. Bollenbach, “Transcription factor kinetics and the emerging
asymmetry in the early mammalian embryo,” Cell Cycle, vol. 11, no. 11.
Taylor and Francis, pp. 2055–2058, 2012.
ista: Pantazis P, Bollenbach MT. 2012. Transcription factor kinetics and the emerging
asymmetry in the early mammalian embryo. Cell Cycle. 11(11), 2055–2058.
mla: Pantazis, Periklis, and Mark Tobias Bollenbach. “Transcription Factor Kinetics
and the Emerging Asymmetry in the Early Mammalian Embryo.” Cell Cycle,
vol. 11, no. 11, Taylor and Francis, 2012, pp. 2055–58, doi:10.4161/cc.20118.
short: P. Pantazis, M.T. Bollenbach, Cell Cycle 11 (2012) 2055–2058.
date_created: 2018-12-11T12:01:44Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T07:41:28Z
day: '01'
department:
- _id: ToBo
doi: 10.4161/cc.20118
intvolume: ' 11'
issue: '11'
language:
- iso: eng
month: '06'
oa_version: None
page: 2055 - 2058
publication: Cell Cycle
publication_status: published
publisher: Taylor and Francis
publist_id: '3531'
quality_controlled: '1'
scopus_import: 1
status: public
title: Transcription factor kinetics and the emerging asymmetry in the early mammalian
embryo
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2012'
...
---
_id: '3161'
abstract:
- lang: eng
text: 'Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by
inducing efflux of cellular potassium. Loss of cellular potassium is known to
potently suppress protein synthesis, leading us to test whether the inhibition
of protein synthesis itself serves as an activating signal for the NLRP3 inflammasome.
Murine bone marrow-derived macrophages, either primed by LPS or unprimed, were
exposed to a panel of inhibitors of ribosomal function: ricin, cycloheximide,
puromycin, pactamycin, and anisomycin. Macrophages were also exposed to nigericin,
ATP, monosodium urate (MSU), and poly I:C. Synthesis of pro-IL-ß and release of
IL-1ß from cells in response to these agents was detected by immunoblotting and
ELISA. Release of intracellular potassium was measured by mass spectrometry. Inhibition
of translation by each of the tested translation inhibitors led to processing
of IL-1ß, which was released from cells. Processing and release of IL-1ß was reduced
or absent from cells deficient in NLRP3, ASC, or caspase-1, demonstrating the
role of the NLRP3 inflammasome. Despite the inability of these inhibitors to trigger
efflux of intracellular potassium, the addition of high extracellular potassium
suppressed activation of the NLRP3 inflammasome. MSU and double-stranded RNA,
which are known to activate the NLRP3 inflammasome, also substantially inhibited
protein translation, supporting a close association between inhibition of translation
and inflammasome activation. These data demonstrate that translational inhibition
itself constitutes a heretofore-unrecognized mechanism underlying IL-1ß dependent
inflammatory signaling and that other physical, chemical, or pathogen-associated
agents that impair translation may lead to IL-1ß-dependent inflammation through
activation of the NLRP3 inflammasome. For agents that inhibit translation through
decreased cellular potassium, the application of high extracellular potassium
restores protein translation and suppresses activation of the NLRP inflammasome.
For agents that inhibit translation through mechanisms that do not involve loss
of potassium, high extracellular potassium suppresses IL-1ß processing through
a mechanism that remains undefined.'
acknowledgement: "Supported by National Institutes of Health grants GM071338 (ML)
and AI059355 (BM).\r\nWe acknowledge the expertise of Dr. Martina Ralle in Department
of Biochemistry and Molecular Biology at OHSU for measurements of potassium using
inductively coupled plasma mass spectrometry."
article_number: e36044
author:
- first_name: Meghan
full_name: Vyleta, Meghan
id: 418901AA-F248-11E8-B48F-1D18A9856A87
last_name: Vyleta
- first_name: John
full_name: Wong, John
last_name: Wong
- first_name: Bruce
full_name: Magun, Bruce
last_name: Magun
citation:
ama: Vyleta M, Wong J, Magun B. Suppression of ribosomal function triggers innate
immune signaling through activation of the NLRP3 inflammasome. PLoS One.
2012;7(5). doi:10.1371/journal.pone.0036044
apa: Vyleta, M., Wong, J., & Magun, B. (2012). Suppression of ribosomal function
triggers innate immune signaling through activation of the NLRP3 inflammasome.
PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0036044
chicago: Vyleta, Meghan, John Wong, and Bruce Magun. “Suppression of Ribosomal Function
Triggers Innate Immune Signaling through Activation of the NLRP3 Inflammasome.”
PLoS One. Public Library of Science, 2012. https://doi.org/10.1371/journal.pone.0036044.
ieee: M. Vyleta, J. Wong, and B. Magun, “Suppression of ribosomal function triggers
innate immune signaling through activation of the NLRP3 inflammasome,” PLoS
One, vol. 7, no. 5. Public Library of Science, 2012.
ista: Vyleta M, Wong J, Magun B. 2012. Suppression of ribosomal function triggers
innate immune signaling through activation of the NLRP3 inflammasome. PLoS One.
7(5), e36044.
mla: Vyleta, Meghan, et al. “Suppression of Ribosomal Function Triggers Innate Immune
Signaling through Activation of the NLRP3 Inflammasome.” PLoS One, vol.
7, no. 5, e36044, Public Library of Science, 2012, doi:10.1371/journal.pone.0036044.
short: M. Vyleta, J. Wong, B. Magun, PLoS One 7 (2012).
date_created: 2018-12-11T12:01:45Z
date_published: 2012-05-14T00:00:00Z
date_updated: 2021-01-12T07:41:29Z
day: '14'
ddc:
- '610'
department:
- _id: SyCr
doi: 10.1371/journal.pone.0036044
file:
- access_level: open_access
checksum: 30cef37e27eaa467f6571b3640282010
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:30Z
date_updated: 2020-07-14T12:46:01Z
file_id: '5082'
file_name: IST-2012-97-v1+1_journal.pone.0036044.pdf
file_size: 2984012
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 7'
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3526'
pubrep_id: '97'
quality_controlled: '1'
scopus_import: 1
status: public
title: Suppression of ribosomal function triggers innate immune signaling through
activation of the NLRP3 inflammasome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2012'
...
---
_id: '3162'
abstract:
- lang: eng
text: Given a dense-time real-valued signal and a parameterized temporal logic formula
with both magnitude and timing parameters, we compute the subset of the parameter
space that renders the formula satisfied by the trace. We provide two preliminary
implementations, one which follows the exact semantics and attempts to compute
the validity domain by quantifier elimination in linear arithmetics and one which
conducts adaptive search in the parameter space.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Eugene
full_name: Asarin, Eugene
last_name: Asarin
- first_name: Alexandre
full_name: Donzé, Alexandre
last_name: Donzé
- first_name: Oded
full_name: Maler, Oded
last_name: Maler
- first_name: Dejan
full_name: Nickovic, Dejan
id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87
last_name: Nickovic
citation:
ama: 'Asarin E, Donzé A, Maler O, Nickovic D. Parametric identification of temporal
properties. In: Vol 7186. Springer; 2012:147-160. doi:10.1007/978-3-642-29860-8_12'
apa: 'Asarin, E., Donzé, A., Maler, O., & Nickovic, D. (2012). Parametric identification
of temporal properties (Vol. 7186, pp. 147–160). Presented at the RV: Runtime
Verification, San Francisco, CA, United States: Springer. https://doi.org/10.1007/978-3-642-29860-8_12'
chicago: Asarin, Eugene, Alexandre Donzé, Oded Maler, and Dejan Nickovic. “Parametric
Identification of Temporal Properties,” 7186:147–60. Springer, 2012. https://doi.org/10.1007/978-3-642-29860-8_12.
ieee: 'E. Asarin, A. Donzé, O. Maler, and D. Nickovic, “Parametric identification
of temporal properties,” presented at the RV: Runtime Verification, San Francisco,
CA, United States, 2012, vol. 7186, pp. 147–160.'
ista: 'Asarin E, Donzé A, Maler O, Nickovic D. 2012. Parametric identification of
temporal properties. RV: Runtime Verification, LNCS, vol. 7186, 147–160.'
mla: Asarin, Eugene, et al. Parametric Identification of Temporal Properties.
Vol. 7186, Springer, 2012, pp. 147–60, doi:10.1007/978-3-642-29860-8_12.
short: E. Asarin, A. Donzé, O. Maler, D. Nickovic, in:, Springer, 2012, pp. 147–160.
conference:
end_date: 2011-09-30
location: San Francisco, CA, United States
name: 'RV: Runtime Verification'
start_date: 2011-09-27
date_created: 2018-12-11T12:01:45Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T07:41:29Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-642-29860-8_12
file:
- access_level: open_access
checksum: ba4a75287008fc64b8fbf78a7476ec32
content_type: application/pdf
creator: dernst
date_created: 2020-05-15T12:50:15Z
date_updated: 2020-07-14T12:46:01Z
file_id: '7862'
file_name: 2012_RV_Asarin.pdf
file_size: 374726
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 7186'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 147 - 160
publication_status: published
publisher: Springer
publist_id: '3525'
quality_controlled: '1'
scopus_import: 1
status: public
title: Parametric identification of temporal properties
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7186
year: '2012'
...
---
_id: '3164'
abstract:
- lang: eng
text: Overview of the Special Issue on structured prediction and inference.
author:
- first_name: Matthew
full_name: Blaschko, Matthew
last_name: Blaschko
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Blaschko M, Lampert C. Guest editorial: Special issue on structured prediction
and inference. International Journal of Computer Vision. 2012;99(3):257-258.
doi:10.1007/s11263-012-0530-y'
apa: 'Blaschko, M., & Lampert, C. (2012). Guest editorial: Special issue on
structured prediction and inference. International Journal of Computer Vision.
Springer. https://doi.org/10.1007/s11263-012-0530-y'
chicago: 'Blaschko, Matthew, and Christoph Lampert. “Guest Editorial: Special Issue
on Structured Prediction and Inference.” International Journal of Computer
Vision. Springer, 2012. https://doi.org/10.1007/s11263-012-0530-y.'
ieee: 'M. Blaschko and C. Lampert, “Guest editorial: Special issue on structured
prediction and inference,” International Journal of Computer Vision, vol.
99, no. 3. Springer, pp. 257–258, 2012.'
ista: 'Blaschko M, Lampert C. 2012. Guest editorial: Special issue on structured
prediction and inference. International Journal of Computer Vision. 99(3), 257–258.'
mla: 'Blaschko, Matthew, and Christoph Lampert. “Guest Editorial: Special Issue
on Structured Prediction and Inference.” International Journal of Computer
Vision, vol. 99, no. 3, Springer, 2012, pp. 257–58, doi:10.1007/s11263-012-0530-y.'
short: M. Blaschko, C. Lampert, International Journal of Computer Vision 99 (2012)
257–258.
date_created: 2018-12-11T12:01:46Z
date_published: 2012-09-01T00:00:00Z
date_updated: 2021-01-12T07:41:30Z
day: '01'
department:
- _id: ChLa
doi: 10.1007/s11263-012-0530-y
intvolume: ' 99'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 257 - 258
publication: International Journal of Computer Vision
publication_status: published
publisher: Springer
publist_id: '3521'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Guest editorial: Special issue on structured prediction and inference'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2012'
...
---
_id: '3165'
abstract:
- lang: eng
text: Computing the winning set for Büchi objectives in alternating games on graphs
is a central problem in computer aided verification with a large number of applications.
The long standing best known upper bound for solving the problem is Õ(n·m), where
n is the number of vertices and m is the number of edges in the graph. We are
the first to break the Õ(n·m) boundary by presenting a new technique that reduces
the running time to O(n 2). This bound also leads to O(n 2) time algorithms for
computing the set of almost-sure winning vertices for Büchi objectives (1) in
alternating games with probabilistic transitions (improving an earlier bound of
Õ(n·m)), (2) in concurrent graph games with constant actions (improving an earlier
bound of O(n 3)), and (3) in Markov decision processes (improving for m > n
4/3 an earlier bound of O(min(m 1.5, m·n 2/3)). We also show that the same technique
can be used to compute the maximal end-component decomposition of a graph in time
O(n 2), which is an improvement over earlier bounds for m > n 4/3. Finally,
we show how to maintain the winning set for Büchi objectives in alternating games
under a sequence of edge insertions or a sequence of edge deletions in O(n) amortized
time per operation. This is the first dynamic algorithm for this problem.
acknowledgement: 'The research was supported by Austrian Science Fund (FWF) Grant
No P 23499-N23 on Modern Graph Algorithmic Techniques in Formal Verification, Vienna
Science and Technology Fund (WWTF) Grant ICT10-002, FWF NFN Grant No S11407-N23
(RiSE), ERC Start grant (279307: Graph Games), and Microsoft faculty fellows award.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Chatterjee K, Henzinger MH. An O(n2) time algorithm for alternating Büchi
games. In: Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms.
SIAM; 2012:1386-1399. doi:10.1137/1.9781611973099.109'
apa: 'Chatterjee, K., & Henzinger, M. H. (2012). An O(n2) time algorithm for
alternating Büchi games. In Proceedings of the Annual ACM-SIAM Symposium on
Discrete Algorithms (pp. 1386–1399). Kyoto, Japan: SIAM. https://doi.org/10.1137/1.9781611973099.109'
chicago: Chatterjee, Krishnendu, and Monika H Henzinger. “An O(N2) Time Algorithm
for Alternating Büchi Games.” In Proceedings of the Annual ACM-SIAM Symposium
on Discrete Algorithms, 1386–99. SIAM, 2012. https://doi.org/10.1137/1.9781611973099.109.
ieee: K. Chatterjee and M. H. Henzinger, “An O(n2) time algorithm for alternating
Büchi games,” in Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms,
Kyoto, Japan, 2012, pp. 1386–1399.
ista: 'Chatterjee K, Henzinger MH. 2012. An O(n2) time algorithm for alternating
Büchi games. Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms.
SODA: Symposium on Discrete Algorithms, 1386–1399.'
mla: Chatterjee, Krishnendu, and Monika H. Henzinger. “An O(N2) Time Algorithm for
Alternating Büchi Games.” Proceedings of the Annual ACM-SIAM Symposium on Discrete
Algorithms, SIAM, 2012, pp. 1386–99, doi:10.1137/1.9781611973099.109.
short: K. Chatterjee, M.H. Henzinger, in:, Proceedings of the Annual ACM-SIAM Symposium
on Discrete Algorithms, SIAM, 2012, pp. 1386–1399.
conference:
end_date: 2012-01-19
location: Kyoto, Japan
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 2012-01-17
date_created: 2018-12-11T12:01:46Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2025-06-02T08:53:48Z
day: '01'
department:
- _id: KrCh
doi: 10.1137/1.9781611973099.109
ec_funded: 1
external_id:
arxiv:
- '1109.5018'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1109.5018
month: '01'
oa: 1
oa_version: None
page: 1386 - 1399
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms
publication_status: published
publisher: SIAM
publist_id: '3519'
pubrep_id: '15'
quality_controlled: '1'
related_material:
record:
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relation: earlier_version
status: public
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relation: later_version
status: public
status: public
title: An O(n2) time algorithm for alternating Büchi games
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '3166'
abstract:
- lang: eng
text: 'There is evidence that the genetic code was established prior to the existence
of proteins, when metabolism was powered by ribozymes. Also, early proto-organisms
had to rely on simple anaerobic bioenergetic processes. In this work I propose
that amino acid fermentation powered metabolism in the RNA world, and that this
was facilitated by proto-adapters, the precursors of the tRNAs. Amino acids were
used as carbon sources rather than as catalytic or structural elements. In modern
bacteria, amino acid fermentation is known as the Stickland reaction. This pathway
involves two amino acids: the first undergoes oxidative deamination, and the second
acts as an electron acceptor through reductive deamination. This redox reaction
results in two keto acids that are employed to synthesise ATP via substrate-level
phosphorylation. The Stickland reaction is the basic bioenergetic pathway of some
bacteria of the genus Clostridium. Two other facts support Stickland fermentation
in the RNA world. First, several Stickland amino acid pairs are synthesised in
abiotic amino acid synthesis. This suggests that amino acids that could be used
as an energy substrate were freely available. Second, anticodons that have complementary
sequences often correspond to amino acids that form Stickland pairs. The main
hypothesis of this paper is that pairs of complementary proto-adapters were assigned
to Stickland amino acids pairs. There are signatures of this hypothesis in the
genetic code. Furthermore, it is argued that the proto-adapters formed double
strands that brought amino acid pairs into proximity to facilitate their mutual
redox reaction, structurally constraining the anticodon pairs that are assigned
to these amino acid pairs. Significance tests which randomise the code are performed
to study the extent of the variability of the energetic (ATP) yield. Random assignments
can lead to a substantial yield of ATP and maintain enough variability, thus selection
can act and refine the assignments into a proto-code that optimises the energetic
yield. Monte Carlo simulations are performed to evaluate the establishment of
these simple proto-codes, based on amino acid substitutions and codon swapping.
In all cases, donor amino acids are assigned to anticodons composed of U+G, and
have low redundancy (1-2 codons), whereas acceptor amino acids are assigned to
the the remaining codons. These bioenergetic and structural constraints allow
for a metabolic role for amino acids before their co-option as catalyst cofactors.
Reviewers: this article was reviewed by Prof. William Martin, Prof. Eors Szathmary
(nominated by Dr. Gaspar Jekely) and Dr. Adam Kun (nominated by Dr. Sandor Pongor)'
acknowledgement: 'The author was supported by the ERC-2009-AdG Grant for project 250152
SELECTIONINFORMATION. '
article_number: '6'
author:
- first_name: Harold
full_name: Vladar, Harold
id: 2A181218-F248-11E8-B48F-1D18A9856A87
last_name: Vladar
orcid: 0000-0002-5985-7653
citation:
ama: de Vladar H. Amino acid fermentation at the origin of the genetic code. Biology
Direct. 2012;7. doi:10.1186/1745-6150-7-6
apa: de Vladar, H. (2012). Amino acid fermentation at the origin of the genetic
code. Biology Direct. BioMed Central. https://doi.org/10.1186/1745-6150-7-6
chicago: Vladar, Harold de. “Amino Acid Fermentation at the Origin of the Genetic
Code.” Biology Direct. BioMed Central, 2012. https://doi.org/10.1186/1745-6150-7-6.
ieee: H. de Vladar, “Amino acid fermentation at the origin of the genetic code,”
Biology Direct, vol. 7. BioMed Central, 2012.
ista: de Vladar H. 2012. Amino acid fermentation at the origin of the genetic code.
Biology Direct. 7, 6.
mla: de Vladar, Harold. “Amino Acid Fermentation at the Origin of the Genetic Code.”
Biology Direct, vol. 7, 6, BioMed Central, 2012, doi:10.1186/1745-6150-7-6.
short: H. de Vladar, Biology Direct 7 (2012).
date_created: 2018-12-11T12:01:46Z
date_published: 2012-02-10T00:00:00Z
date_updated: 2021-01-12T07:41:31Z
day: '10'
ddc:
- '570'
- '576'
department:
- _id: NiBa
doi: 10.1186/1745-6150-7-6
ec_funded: 1
file:
- access_level: open_access
checksum: e511e401e239ef608a7fd79b21a06d78
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:44Z
date_updated: 2020-07-14T12:46:02Z
file_id: '5166'
file_name: IST-2012-99-v1+1_1745-6150-7-6.pdf
file_size: 4099536
relation: main_file
file_date_updated: 2020-07-14T12:46:02Z
has_accepted_license: '1'
intvolume: ' 7'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Biology Direct
publication_status: published
publisher: BioMed Central
publist_id: '3518'
pubrep_id: '99'
quality_controlled: '1'
status: public
title: Amino acid fermentation at the origin of the genetic code
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2012'
...
---
_id: '3167'
article_type: letter_note
author:
- first_name: Michele
full_name: Weber, Michele
id: 3A3FC708-F248-11E8-B48F-1D18A9856A87
last_name: Weber
citation:
ama: Weber M. NextGen speaks 13 . Science. 2012;336(6077):32-34. doi:10.1126/science.336.6077.32
apa: Weber, M. (2012). NextGen speaks 13 . Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.336.6077.32
chicago: Weber, Michele. “NextGen Speaks 13 .” Science. American Association
for the Advancement of Science, 2012. https://doi.org/10.1126/science.336.6077.32.
ieee: M. Weber, “NextGen speaks 13 ,” Science, vol. 336, no. 6077. American
Association for the Advancement of Science, pp. 32–34, 2012.
ista: Weber M. 2012. NextGen speaks 13 . Science. 336(6077), 32–34.
mla: Weber, Michele. “NextGen Speaks 13 .” Science, vol. 336, no. 6077, American
Association for the Advancement of Science, 2012, pp. 32–34, doi:10.1126/science.336.6077.32.
short: M. Weber, Science 336 (2012) 32–34.
date_created: 2018-12-11T12:01:47Z
date_published: 2012-04-06T00:00:00Z
date_updated: 2021-01-12T07:41:32Z
day: '06'
department:
- _id: MiSi
doi: 10.1126/science.336.6077.32
external_id:
pmid:
- '22491839'
intvolume: ' 336'
issue: '6077'
language:
- iso: eng
month: '04'
oa_version: None
page: 32-34
pmid: 1
popular_science: '1'
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '3516'
status: public
title: 'NextGen speaks 13 '
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 336
year: '2012'
...