[{"oa":1,"year":"2022","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"publication":"Nature Communications","date_updated":"2023-08-04T09:15:31Z","article_number":"6326","article_type":"original","department":[{"_id":"StFr"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2022-10-24T00:00:00Z","external_id":{"pmid":["36280671"],"isi":["000871563700006"]},"date_created":"2023-01-16T09:45:09Z","scopus_import":"1","publisher":"Springer Nature","intvolume":"        13","isi":1,"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"title":"On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering","author":[{"last_name":"Prehal","full_name":"Prehal, Christian","first_name":"Christian"},{"first_name":"Jean-Marc","full_name":"von Mentlen, Jean-Marc","last_name":"von Mentlen"},{"first_name":"Sara","last_name":"Drvarič Talian","full_name":"Drvarič Talian, Sara"},{"first_name":"Alen","full_name":"Vizintin, Alen","last_name":"Vizintin"},{"last_name":"Dominko","full_name":"Dominko, Robert","first_name":"Robert"},{"first_name":"Heinz","last_name":"Amenitsch","full_name":"Amenitsch, Heinz"},{"first_name":"Lionel","last_name":"Porcar","full_name":"Porcar, Lionel"},{"first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319"},{"full_name":"Wood, Vanessa","last_name":"Wood","first_name":"Vanessa"}],"_id":"12208","abstract":[{"lang":"eng","text":"The inadequate understanding of the mechanisms that reversibly convert molecular sulfur (S) into lithium sulfide (Li<jats:sub>2</jats:sub>S) via soluble polysulfides (PSs) formation impedes the development of high-performance lithium-sulfur (Li-S) batteries with non-aqueous electrolyte solutions. Here, we use operando small and wide angle X-ray scattering and operando small angle neutron scattering (SANS) measurements to track the nucleation, growth and dissolution of solid deposits from atomic to sub-micron scales during real-time Li-S cell operation. In particular, stochastic modelling based on the SANS data allows quantifying the nanoscale phase evolution during battery cycling. We show that next to nano-crystalline Li<jats:sub>2</jats:sub>S the deposit comprises solid short-chain PSs particles. The analysis of the experimental data suggests that initially, Li<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub> precipitates from the solution and then is partially converted via solid-state electroreduction to Li<jats:sub>2</jats:sub>S. We further demonstrate that mass transport, rather than electron transport through a thin passivating film, limits the discharge capacity and rate performance in Li-S cells."}],"doi":"10.1038/s41467-022-33931-4","publication_identifier":{"issn":["2041-1723"]},"acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant NanoEvolution, grant agreement No 894042. The authors acknowledge the CERIC-ERIC Consortium for the access to the Austrian SAXS beamline and TU Graz for support through the Lead Project LP-03.\r\nLikewise, the use of SOMAPP Lab, a core facility supported by the Austrian Federal Ministry of Education, Science and Research, the Graz University of Technology, the University of Graz, and Anton Paar GmbH is acknowledged. In addition, the authors acknowledge access to the D-22SANS beamline at the ILL neutron source. Electron microscopy measurements were performed at the Scientific Scenter for Optical and Electron Microscopy (ScopeM) of the Swiss Federal Institute of Technology. C.P. and J.M.M. thank A. Senol for her support with the SANS\r\nbeamtime preparation. S.D.T, A.V. and R.D. acknowledge the financial support by the Slovenian Research Agency (ARRS) research core funding P2-0393 and P2-0423. Furthermore, A.V. acknowledge the funding from the Slovenian Research Agency, research project Z2−1863.\r\nS.A.F. is indebted to IST Austria for support. ","publication_status":"published","status":"public","citation":{"chicago":"Prehal, Christian, Jean-Marc von Mentlen, Sara Drvarič Talian, Alen Vizintin, Robert Dominko, Heinz Amenitsch, Lionel Porcar, Stefan Alexander Freunberger, and Vanessa Wood. “On the Nanoscale Structural Evolution of Solid Discharge Products in Lithium-Sulfur Batteries Using Operando Scattering.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-33931-4\">https://doi.org/10.1038/s41467-022-33931-4</a>.","mla":"Prehal, Christian, et al. “On the Nanoscale Structural Evolution of Solid Discharge Products in Lithium-Sulfur Batteries Using Operando Scattering.” <i>Nature Communications</i>, vol. 13, 6326, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-33931-4\">10.1038/s41467-022-33931-4</a>.","ieee":"C. Prehal <i>et al.</i>, “On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Prehal, C., von Mentlen, J.-M., Drvarič Talian, S., Vizintin, A., Dominko, R., Amenitsch, H., … Wood, V. (2022). On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-33931-4\">https://doi.org/10.1038/s41467-022-33931-4</a>","ama":"Prehal C, von Mentlen J-M, Drvarič Talian S, et al. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-33931-4\">10.1038/s41467-022-33931-4</a>","ista":"Prehal C, von Mentlen J-M, Drvarič Talian S, Vizintin A, Dominko R, Amenitsch H, Porcar L, Freunberger SA, Wood V. 2022. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. Nature Communications. 13, 6326.","short":"C. Prehal, J.-M. von Mentlen, S. Drvarič Talian, A. Vizintin, R. Dominko, H. Amenitsch, L. Porcar, S.A. Freunberger, V. Wood, Nature Communications 13 (2022)."},"day":"24","month":"10","pmid":1,"file_date_updated":"2023-01-27T07:19:11Z","ddc":["540"],"oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T07:19:11Z","file_id":"12411","creator":"dernst","file_size":4216931,"relation":"main_file","file_name":"2022_NatureCommunications_Prehal.pdf","date_updated":"2023-01-27T07:19:11Z","success":1,"checksum":"5034336dbf0f860030ef745c08df9e0e","content_type":"application/pdf","access_level":"open_access"}],"has_accepted_license":"1","article_processing_charge":"No","volume":13},{"ec_funded":1,"status":"public","publication_status":"published","acknowledgement":"We thank K. Sampath, A. Pauli and Y. Bellaїche for feedback on the manuscript. We also thank the members of the Heisenberg group, in particular A. Schauer and F. Nur Arslan, for help, technical advice and discussions, and the Bioimaging and Life Science facilities at IST\r\nAustria for continuous support. We thank C. Flandoli for the artwork in the figures. This work was supported by postdoctoral fellowships from EMBO (LTF-850-2017) and HFSP (LT000429/2018-L2) to D.P. and the European Union (European Research Council starting grant 851288 to É.H. and European Research Council advanced grant 742573 to C.-P.H.).","project":[{"grant_number":"ALTF 850-2017","_id":"26520D1E-B435-11E9-9278-68D0E5697425","name":"Coordination of mesendoderm cell fate specification and internalization during zebrafish gastrulation"},{"grant_number":"ALTF 850-2017","_id":"26520D1E-B435-11E9-9278-68D0E5697425","name":"Coordination of mesendoderm cell fate specification and internalization during zebrafish gastrulation"},{"_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"},{"call_identifier":"H2020","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","_id":"260F1432-B435-11E9-9278-68D0E5697425","grant_number":"742573"}],"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"doi":"10.1038/s41567-022-01787-6","issue":"12","abstract":[{"lang":"eng","text":"Embryo development requires biochemical signalling to generate patterns of cell fates and active mechanical forces to drive tissue shape changes. However, how these processes are coordinated, and how tissue patterning is preserved despite the cellular flows occurring during morphogenesis, remains poorly understood. Gastrulation is a crucial embryonic stage that involves both patterning and internalization of the mesendoderm germ layer tissue. Here we show that, in zebrafish embryos, a gradient in Nodal signalling orchestrates pattern-preserving internalization movements by triggering a motility-driven unjamming transition. In addition to its role as a morphogen determining embryo patterning, graded Nodal signalling mechanically subdivides the mesendoderm into a small fraction of highly protrusive leader cells, able to autonomously internalize via local unjamming, and less protrusive followers, which need to be pulled inwards by the leaders. The Nodal gradient further enforces a code of preferential adhesion coupling leaders to their immediate followers, resulting in a collective and ordered mode of internalization that preserves mesendoderm patterning. Integrating this dual mechanical role of Nodal signalling into minimal active particle simulations quantitatively predicts both physiological and experimentally perturbed internalization movements. This provides a quantitative framework for how a morphogen-encoded unjamming transition can bidirectionally couple tissue mechanics with patterning during complex three-dimensional morphogenesis."}],"_id":"12209","author":[{"last_name":"Nunes Pinheiro","full_name":"Nunes Pinheiro, Diana C","first_name":"Diana C","id":"2E839F16-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4333-7503"},{"full_name":"Kardos, Roland","last_name":"Kardos","id":"4039350E-F248-11E8-B48F-1D18A9856A87","first_name":"Roland"},{"orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","full_name":"Hannezo, Edouard B","last_name":"Hannezo"},{"orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J"}],"title":"Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming","volume":18,"article_processing_charge":"No","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T07:32:01Z","file_id":"12412","date_updated":"2023-01-27T07:32:01Z","success":1,"checksum":"c86a8e8d80d1bfc46d56a01e88a2526a","content_type":"application/pdf","access_level":"open_access","file_size":36703569,"creator":"dernst","relation":"main_file","file_name":"2022_NaturePhysics_Pinheiro.pdf"}],"oa_version":"Published Version","ddc":["570"],"month":"12","file_date_updated":"2023-01-27T07:32:01Z","day":"01","citation":{"chicago":"Nunes Pinheiro, Diana C, Roland Kardos, Edouard B Hannezo, and Carl-Philipp J Heisenberg. “Morphogen Gradient Orchestrates Pattern-Preserving Tissue Morphogenesis via Motility-Driven Unjamming.” <i>Nature Physics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41567-022-01787-6\">https://doi.org/10.1038/s41567-022-01787-6</a>.","mla":"Nunes Pinheiro, Diana C., et al. “Morphogen Gradient Orchestrates Pattern-Preserving Tissue Morphogenesis via Motility-Driven Unjamming.” <i>Nature Physics</i>, vol. 18, no. 12, Springer Nature, 2022, pp. 1482–93, doi:<a href=\"https://doi.org/10.1038/s41567-022-01787-6\">10.1038/s41567-022-01787-6</a>.","ama":"Nunes Pinheiro DC, Kardos R, Hannezo EB, Heisenberg C-PJ. Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. <i>Nature Physics</i>. 2022;18(12):1482-1493. doi:<a href=\"https://doi.org/10.1038/s41567-022-01787-6\">10.1038/s41567-022-01787-6</a>","ista":"Nunes Pinheiro DC, Kardos R, Hannezo EB, Heisenberg C-PJ. 2022. Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. Nature Physics. 18(12), 1482–1493.","short":"D.C. Nunes Pinheiro, R. Kardos, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 18 (2022) 1482–1493.","ieee":"D. C. Nunes Pinheiro, R. Kardos, E. B. Hannezo, and C.-P. J. Heisenberg, “Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming,” <i>Nature Physics</i>, vol. 18, no. 12. Springer Nature, pp. 1482–1493, 2022.","apa":"Nunes Pinheiro, D. C., Kardos, R., Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2022). Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-022-01787-6\">https://doi.org/10.1038/s41567-022-01787-6</a>"},"article_type":"original","page":"1482-1493","date_updated":"2023-08-04T09:15:58Z","publication":"Nature Physics","keyword":["General Physics and Astronomy"],"year":"2022","oa":1,"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"isi":1,"intvolume":"        18","publisher":"Springer Nature","scopus_import":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"date_created":"2023-01-16T09:45:19Z","date_published":"2022-12-01T00:00:00Z","external_id":{"isi":["000871319900002"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"CaHe"},{"_id":"EdHa"}]},{"date_updated":"2023-08-04T09:22:14Z","publication":"Mathematische Zeitschrift","article_type":"original","page":"2327-2352","oa":1,"keyword":["General Mathematics"],"year":"2022","main_file_link":[{"url":"https://arxiv.org/abs/2101.00584","open_access":"1"}],"intvolume":"       302","publisher":"Springer Nature","type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"JaMa"}],"scopus_import":"1","date_created":"2023-01-16T09:45:31Z","date_published":"2022-12-01T00:00:00Z","external_id":{"arxiv":["2101.00584"],"isi":["000859680700001"]},"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"},{"name":"Curvature-dimension in noncommutative analysis","grant_number":"M03337","_id":"eb958bca-77a9-11ec-83b8-c565cb50d8d6"}],"publication_identifier":{"eissn":["1432-1823"],"issn":["0025-5874"]},"ec_funded":1,"publication_status":"published","status":"public","acknowledgement":"Yu. K. thanks Professor Waldemar Hebisch for valuable discussions on the general context of multipliers on Lie groups. This work was started during an ICL-CNRS fellowship of the second\r\nnamed author at the Imperial College London. Yu. K. is supported by the ANR-19-CE40-0002 grant of the French National Research Agency (ANR). H. Z. is supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411 and the Lise Meitner fellowship, Austrian Science Fund (FWF) M3337. R. A. was supported by the EPSRC grant EP/R003025. M. R. is supported by the EPSRC grant EP/R003025/2 and by the FWO Odysseus 1 grant G.0H94.18N: Analysis and Partial Differential Equations.","_id":"12210","author":[{"last_name":"Akylzhanov","full_name":"Akylzhanov, Rauan","first_name":"Rauan"},{"full_name":"Kuznetsova, Yulia","last_name":"Kuznetsova","first_name":"Yulia"},{"first_name":"Michael","full_name":"Ruzhansky, Michael","last_name":"Ruzhansky"},{"id":"D8F41E38-9E66-11E9-A9E2-65C2E5697425","first_name":"Haonan","full_name":"Zhang, Haonan","last_name":"Zhang"}],"title":"Norms of certain functions of a distinguished Laplacian on the ax + b groups","doi":"10.1007/s00209-022-03143-z","issue":"4","abstract":[{"lang":"eng","text":"The aim of this paper is to find new estimates for the norms of functions of a (minus) distinguished Laplace operator L on the ‘ax+b’ groups. The central part is devoted to spectrally localized wave propagators, that is, functions of the type ψ(L−−√)exp(itL−−√), with ψ∈C0(R). We show that for t→+∞, the convolution kernel kt of this operator satisfies\r\n∥kt∥1≍t,∥kt∥∞≍1,\r\nso that the upper estimates of D. Müller and C. Thiele (Studia Math., 2007) are sharp. As a necessary component, we recall the Plancherel density of L and spend certain time presenting and comparing different approaches to its calculation. Using its explicit form, we estimate uniform norms of several functions of the shifted Laplace-Beltrami operator Δ~, closely related to L. The functions include in particular exp(−tΔ~γ), t>0,γ>0, and (Δ~−z)s, with complex z, s."}],"arxiv":1,"volume":302,"article_processing_charge":"No","month":"12","day":"01","citation":{"apa":"Akylzhanov, R., Kuznetsova, Y., Ruzhansky, M., &#38; Zhang, H. (2022). Norms of certain functions of a distinguished Laplacian on the ax + b groups. <i>Mathematische Zeitschrift</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00209-022-03143-z\">https://doi.org/10.1007/s00209-022-03143-z</a>","ieee":"R. Akylzhanov, Y. Kuznetsova, M. Ruzhansky, and H. Zhang, “Norms of certain functions of a distinguished Laplacian on the ax + b groups,” <i>Mathematische Zeitschrift</i>, vol. 302, no. 4. Springer Nature, pp. 2327–2352, 2022.","ista":"Akylzhanov R, Kuznetsova Y, Ruzhansky M, Zhang H. 2022. Norms of certain functions of a distinguished Laplacian on the ax + b groups. Mathematische Zeitschrift. 302(4), 2327–2352.","ama":"Akylzhanov R, Kuznetsova Y, Ruzhansky M, Zhang H. Norms of certain functions of a distinguished Laplacian on the ax + b groups. <i>Mathematische Zeitschrift</i>. 2022;302(4):2327-2352. doi:<a href=\"https://doi.org/10.1007/s00209-022-03143-z\">10.1007/s00209-022-03143-z</a>","short":"R. Akylzhanov, Y. Kuznetsova, M. Ruzhansky, H. Zhang, Mathematische Zeitschrift 302 (2022) 2327–2352.","chicago":"Akylzhanov, Rauan, Yulia Kuznetsova, Michael Ruzhansky, and Haonan Zhang. “Norms of Certain Functions of a Distinguished Laplacian on the Ax + b Groups.” <i>Mathematische Zeitschrift</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00209-022-03143-z\">https://doi.org/10.1007/s00209-022-03143-z</a>.","mla":"Akylzhanov, Rauan, et al. “Norms of Certain Functions of a Distinguished Laplacian on the Ax + b Groups.” <i>Mathematische Zeitschrift</i>, vol. 302, no. 4, Springer Nature, 2022, pp. 2327–52, doi:<a href=\"https://doi.org/10.1007/s00209-022-03143-z\">10.1007/s00209-022-03143-z</a>."},"oa_version":"Preprint"},{"oa_version":"Published Version","file_date_updated":"2023-01-27T07:53:18Z","month":"09","ddc":["570"],"day":"21","citation":{"mla":"Martín-Belmonte, Alejandro, et al. “Nanoscale Alterations in GABAB Receptors and GIRK Channel Organization on the Hippocampus of APP/PS1 Mice.” <i>Alzheimer’s Research &#38; Therapy</i>, vol. 14, 136, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1186/s13195-022-01078-5\">10.1186/s13195-022-01078-5</a>.","chicago":"Martín-Belmonte, Alejandro, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, et al. “Nanoscale Alterations in GABAB Receptors and GIRK Channel Organization on the Hippocampus of APP/PS1 Mice.” <i>Alzheimer’s Research &#38; Therapy</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1186/s13195-022-01078-5\">https://doi.org/10.1186/s13195-022-01078-5</a>.","short":"A. Martín-Belmonte, C. Aguado, R. Alfaro-Ruiz, A.E. Moreno-Martínez, L. de la Ossa, E. Aso, L. Gómez-Acero, R. Shigemoto, Y. Fukazawa, F. Ciruela, R. Luján, Alzheimer’s Research &#38; Therapy 14 (2022).","ama":"Martín-Belmonte A, Aguado C, Alfaro-Ruiz R, et al. Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice. <i>Alzheimer’s Research &#38; Therapy</i>. 2022;14. doi:<a href=\"https://doi.org/10.1186/s13195-022-01078-5\">10.1186/s13195-022-01078-5</a>","ista":"Martín-Belmonte A, Aguado C, Alfaro-Ruiz R, Moreno-Martínez AE, de la Ossa L, Aso E, Gómez-Acero L, Shigemoto R, Fukazawa Y, Ciruela F, Luján R. 2022. Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice. Alzheimer’s Research &#38; Therapy. 14, 136.","ieee":"A. Martín-Belmonte <i>et al.</i>, “Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice,” <i>Alzheimer’s Research &#38; Therapy</i>, vol. 14. Springer Nature, 2022.","apa":"Martín-Belmonte, A., Aguado, C., Alfaro-Ruiz, R., Moreno-Martínez, A. E., de la Ossa, L., Aso, E., … Luján, R. (2022). Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice. <i>Alzheimer’s Research &#38; Therapy</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13195-022-01078-5\">https://doi.org/10.1186/s13195-022-01078-5</a>"},"article_processing_charge":"No","volume":14,"has_accepted_license":"1","file":[{"date_updated":"2023-01-27T07:53:18Z","success":1,"checksum":"88e49715ad6a1abf0fdb27efd65368dc","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_size":11013325,"creator":"dernst","file_name":"2022_AlzheimersResearch_MartinBelmont.pdf","date_created":"2023-01-27T07:53:18Z","file_id":"12413"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1186/s13195-022-01078-5","abstract":[{"lang":"eng","text":"Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity. Precisely, a dysfunction in metabotropic GABAB receptor signalling through G protein-gated inwardly rectifying K+ (GIRK or Kir3) channels on the hippocampus has been postulated. Thus, we determined the impact of amyloid-β (Aβ) pathology in GIRK channel density, subcellular distribution, and its association with GABAB receptors in hippocampal CA1 pyramidal neurons from the APP/PS1 mouse model using quantitative SDS-digested freeze-fracture replica labelling (SDS-FRL) and proximity ligation in situ assay (P-LISA). In wild type mice, single SDS-FRL detection revealed a similar dendritic gradient for GIRK1 and GIRK2 in CA1 pyramidal cells, with higher densities in spines, and GIRK3 showed a lower and uniform distribution. Double SDS-FRL showed a co-clustering of GIRK2 and GIRK1 in post- and presynaptic compartments, but not for GIRK2 and GIRK3. Likewise, double GABAB1 and GIRK2 SDS-FRL detection displayed a high degree of co-clustering in nanodomains (40–50 nm) mostly in spines and axon terminals. In APP/PS1 mice, the density of GIRK2 and GIRK1, but not for GIRK3, was significantly reduced along the neuronal surface of CA1 pyramidal cells and in axon terminals contacting them. Importantly, GABAB1 and GIRK2 co-clustering was not present in APP/PS1 mice. Similarly, P-LISA experiments revealed a significant reduction in GABAB1 and GIRK2 interaction on the hippocampus of this animal model. Overall, our results provide compelling evidence showing a significant reduction on the cell surface density of pre- and postsynaptic GIRK1 and GIRK2, but not GIRK3, and a decline in GABAB receptors and GIRK2 channels co-clustering in hippocampal pyramidal neurons from APP/PS1 mice, thus suggesting that a disruption in the GABAB receptor–GIRK channel membrane assembly causes dysregulation in the GABAB signalling via GIRK channels in this AD animal model."}],"_id":"12212","author":[{"first_name":"Alejandro","last_name":"Martín-Belmonte","full_name":"Martín-Belmonte, Alejandro"},{"full_name":"Aguado, Carolina","last_name":"Aguado","first_name":"Carolina"},{"first_name":"Rocío","full_name":"Alfaro-Ruiz, Rocío","last_name":"Alfaro-Ruiz"},{"last_name":"Moreno-Martínez","full_name":"Moreno-Martínez, Ana Esther","first_name":"Ana Esther"},{"first_name":"Luis","full_name":"de la Ossa, Luis","last_name":"de la Ossa"},{"first_name":"Ester","last_name":"Aso","full_name":"Aso, Ester"},{"first_name":"Laura","full_name":"Gómez-Acero, Laura","last_name":"Gómez-Acero"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Yugo","last_name":"Fukazawa","full_name":"Fukazawa, Yugo"},{"first_name":"Francisco","last_name":"Ciruela","full_name":"Ciruela, Francisco"},{"first_name":"Rafael","full_name":"Luján, Rafael","last_name":"Luján"}],"title":"Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice","acknowledgement":"We thank Ms. Diane Latawiec for the English revision of the manuscript. Funding sources were the Spanish Ministerio de Economía y Competitividad, Junta de Comunidades de Castilla-La Mancha (Spain), and Life Science Innovation Center at University of Fukui. We thank Centres de Recerca de Catalunya (CERCA) Programme/Generalitat de Catalunya for IDIBELL institutional support. We thank Hitoshi Takagi and Takako Maegawa at the University of Fukui for their technical assistance on SDS-FRL experiments.\r\nThis work was supported by grants from the Spanish Ministerio de Economía y Competitividad (BFU2015-63769-R, RTI2018-095812-B-I00, and PID2021-125875OB-I00) and Junta de Comunidades de Castilla-La Mancha (SBPLY/17/180501/000229 and SBPLY/21/180501/000064) to RL, Life Science Innovation Center at University of Fukui and JSPS KAKENHI (Grant Numbers 16H04662, 19H03323, and 20H05058) to YF, and Margarita Salas fellowship from Ministerio de Universidades and Universidad de Castilla-La Mancha to AMB.","status":"public","publication_status":"published","publication_identifier":{"issn":["1758-9193"]},"scopus_import":"1","date_created":"2023-01-16T09:45:51Z","date_published":"2022-09-21T00:00:00Z","external_id":{"isi":["000857985500001"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"RySh"}],"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","isi":1,"intvolume":"        14","publisher":"Springer Nature","keyword":["Cognitive Neuroscience","Neurology (clinical)","Neurology"],"year":"2022","oa":1,"article_type":"original","article_number":"136","date_updated":"2023-08-04T09:23:10Z","publication":"Alzheimer's Research & Therapy"},{"has_accepted_license":"1","volume":7,"article_processing_charge":"No","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T07:59:27Z","file_id":"12414","checksum":"d93b477b5b95c0d1b8f9fef90a81f565","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-27T07:59:27Z","success":1,"relation":"main_file","file_size":1852598,"creator":"dernst","file_name":"2022_NPJ_Paerschke.pdf"}],"oa_version":"Published Version","day":"10","citation":{"apa":"Paerschke, E., Chen, W.-C., Ray, R., &#38; Chen, C.-C. (2022). Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain. <i>Npj Quantum Materials</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41535-022-00496-w\">https://doi.org/10.1038/s41535-022-00496-w</a>","ieee":"E. Paerschke, W.-C. Chen, R. Ray, and C.-C. Chen, “Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain,” <i>npj Quantum Materials</i>, vol. 7. Springer Nature, 2022.","short":"E. Paerschke, W.-C. Chen, R. Ray, C.-C. Chen, Npj Quantum Materials 7 (2022).","ista":"Paerschke E, Chen W-C, Ray R, Chen C-C. 2022. Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain. npj Quantum Materials. 7, 90.","ama":"Paerschke E, Chen W-C, Ray R, Chen C-C. Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain. <i>npj Quantum Materials</i>. 2022;7. doi:<a href=\"https://doi.org/10.1038/s41535-022-00496-w\">10.1038/s41535-022-00496-w</a>","mla":"Paerschke, Ekaterina, et al. “Evolution of Electronic and Magnetic Properties of Sr₂IrO₄ under Strain.” <i>Npj Quantum Materials</i>, vol. 7, 90, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41535-022-00496-w\">10.1038/s41535-022-00496-w</a>.","chicago":"Paerschke, Ekaterina, Wei-Chih Chen, Rajyavardhan Ray, and Cheng-Chien Chen. “Evolution of Electronic and Magnetic Properties of Sr₂IrO₄ under Strain.” <i>Npj Quantum Materials</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41535-022-00496-w\">https://doi.org/10.1038/s41535-022-00496-w</a>."},"ddc":["530"],"month":"09","file_date_updated":"2023-01-27T07:59:27Z","status":"public","acknowledgement":"E.M.P. thanks Eugenio Paris, Thorsten Schmitt, Krzysztof Wohlfeld, and other coauthors for an inspiring previous collaboration23, and is grateful to Gang Cao, Ambrose Seo, and Jungho Kim for insightful discussions. R.R. acknowledges helpful discussion with Sanjeev Kumar and Manuel Richter. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 754411. C.C.C. acknowledges support from the U.S. National Science Foundation Award No. DMR-2142801.","publication_status":"published","ec_funded":1,"publication_identifier":{"eissn":["2397-4648"]},"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"abstract":[{"lang":"eng","text":"Motivated by properties-controlling potential of the strain, we investigate strain dependence of structure, electronic, and magnetic properties of Sr2IrO4 using complementary theoretical tools: ab-initio calculations, analytical approaches (rigid octahedra picture, Slater-Koster integrals), and extended t−J model. We find that strain affects both Ir-Ir distance and Ir-O-Ir angle, and the rigid octahedra picture is not relevant. Second, we find fundamentally different behavior for compressive and tensile strain. One remarkable feature is the formation of two subsets of bond- and orbital-dependent carriers, a compass-like model, under compression. This originates from the strain-induced renormalization of the Ir-O-Ir superexchange and O on-site energy. We also show that under compressive (tensile) strain, Fermi surface becomes highly dispersive (relatively flat). Already at a tensile strain of 1.5%, we observe spectral weight redistribution, with the low-energy band acquiring almost purely singlet character. These results can be directly compared with future experiments."}],"doi":"10.1038/s41535-022-00496-w","author":[{"orcid":"0000-0003-0853-8182","full_name":"Paerschke, Ekaterina","last_name":"Paerschke","id":"8275014E-6063-11E9-9B7F-6338E6697425","first_name":"Ekaterina"},{"first_name":"Wei-Chih","full_name":"Chen, Wei-Chih","last_name":"Chen"},{"last_name":"Ray","full_name":"Ray, Rajyavardhan","first_name":"Rajyavardhan"},{"last_name":"Chen","full_name":"Chen, Cheng-Chien","first_name":"Cheng-Chien"}],"title":"Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain","_id":"12213","isi":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"         7","publisher":"Springer Nature","external_id":{"isi":["000852381200003"]},"date_published":"2022-09-10T00:00:00Z","scopus_import":"1","date_created":"2023-01-16T09:46:01Z","department":[{"_id":"MiLe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"link":[{"url":"https://doi.org/10.1038/s41535-022-00510-1","relation":"erratum"}]},"article_type":"original","article_number":"90","publication":"npj Quantum Materials","date_updated":"2023-08-04T09:23:43Z","year":"2022","keyword":["Condensed Matter Physics","Electronic","Optical and Magnetic Materials"],"oa":1},{"date_created":"2023-01-16T09:46:13Z","scopus_import":"1","external_id":{"isi":["000854878500001"],"arxiv":["2102.02037"]},"date_published":"2022-09-18T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"LaEr"}],"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","isi":1,"publisher":"Wiley","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2102.02037","open_access":"1"}],"intvolume":"       106","keyword":["General Mathematics"],"year":"2022","oa":1,"page":"3865-3894","article_type":"original","date_updated":"2023-08-04T09:24:17Z","publication":"Journal of the London Mathematical Society","oa_version":"Preprint","month":"09","citation":{"ieee":"G. P. Gehér, T. Titkos, and D. Virosztek, “The isometry group of Wasserstein spaces: The Hilbertian case,” <i>Journal of the London Mathematical Society</i>, vol. 106, no. 4. Wiley, pp. 3865–3894, 2022.","apa":"Gehér, G. P., Titkos, T., &#38; Virosztek, D. (2022). The isometry group of Wasserstein spaces: The Hilbertian case. <i>Journal of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/jlms.12676\">https://doi.org/10.1112/jlms.12676</a>","ama":"Gehér GP, Titkos T, Virosztek D. The isometry group of Wasserstein spaces: The Hilbertian case. <i>Journal of the London Mathematical Society</i>. 2022;106(4):3865-3894. doi:<a href=\"https://doi.org/10.1112/jlms.12676\">10.1112/jlms.12676</a>","ista":"Gehér GP, Titkos T, Virosztek D. 2022. The isometry group of Wasserstein spaces: The Hilbertian case. Journal of the London Mathematical Society. 106(4), 3865–3894.","short":"G.P. Gehér, T. Titkos, D. Virosztek, Journal of the London Mathematical Society 106 (2022) 3865–3894.","mla":"Gehér, György Pál, et al. “The Isometry Group of Wasserstein Spaces: The Hilbertian Case.” <i>Journal of the London Mathematical Society</i>, vol. 106, no. 4, Wiley, 2022, pp. 3865–94, doi:<a href=\"https://doi.org/10.1112/jlms.12676\">10.1112/jlms.12676</a>.","chicago":"Gehér, György Pál, Tamás Titkos, and Daniel Virosztek. “The Isometry Group of Wasserstein Spaces: The Hilbertian Case.” <i>Journal of the London Mathematical Society</i>. Wiley, 2022. <a href=\"https://doi.org/10.1112/jlms.12676\">https://doi.org/10.1112/jlms.12676</a>."},"day":"18","article_processing_charge":"No","volume":106,"arxiv":1,"doi":"10.1112/jlms.12676","abstract":[{"text":"Motivated by Kloeckner’s result on the isometry group of the quadratic Wasserstein space W2(Rn), we describe the isometry group Isom(Wp(E)) for all parameters 0 < p < ∞ and for all separable real Hilbert spaces E. In particular, we show that Wp(X) is isometrically rigid for all Polish space X whenever 0 < p < 1. This is a consequence of our more general result: we prove that W1(X) is isometrically rigid if X is a complete separable metric space that satisfies the strict triangle inequality. Furthermore, we show that this latter rigidity result does not generalise to parameters p > 1, by solving Kloeckner’s problem affirmatively on the existence of mass-splitting isometries. ","lang":"eng"}],"issue":"4","_id":"12214","title":"The isometry group of Wasserstein spaces: The Hilbertian case","author":[{"last_name":"Gehér","full_name":"Gehér, György Pál","first_name":"György Pál"},{"last_name":"Titkos","full_name":"Titkos, Tamás","first_name":"Tamás"},{"orcid":"0000-0003-1109-5511","full_name":"Virosztek, Daniel","last_name":"Virosztek","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel"}],"ec_funded":1,"publication_status":"published","acknowledgement":"Geher was supported by the Leverhulme Trust Early Career Fellowship (ECF-2018-125), and also by the Hungarian National Research, Development and Innovation Office - NKFIH (grant no. K115383 and K134944).\r\nTitkos was supported by the Hungarian National Research, Development and Innovation Office - NKFIH (grant no. PD128374, grant no. K115383 and K134944), by the J´anos Bolyai Research Scholarship of the Hungarian Academy of Sciences, and by the UNKP-20-5-BGE-1 New National Excellence Program of the ´Ministry of Innovation and Technology.\r\nVirosztek was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 846294, by the Momentum program of the Hungarian Academy of Sciences under grant agreement no. LP2021-15/2021, and partially supported by the Hungarian National Research, Development and Innovation Office - NKFIH (grants no. K124152 and no. KH129601). ","status":"public","project":[{"grant_number":"846294","_id":"26A455A6-B435-11E9-9278-68D0E5697425","name":"Geometric study of Wasserstein spaces and free probability","call_identifier":"H2020"}],"publication_identifier":{"eissn":["1469-7750"],"issn":["0024-6107"]}},{"year":"2022","keyword":["Discrete Mathematics and Combinatorics","Geometry and Topology","Numerical Analysis","Algebra and Number Theory"],"oa":1,"page":"289-310","article_type":"original","publication":"Linear Algebra and its Applications","date_updated":"2023-08-04T09:24:51Z","date_published":"2022-12-01T00:00:00Z","external_id":{"isi":["000860689600014"]},"date_created":"2023-01-16T09:46:38Z","scopus_import":"1","department":[{"_id":"JaMa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","publisher":"Elsevier","intvolume":"       654","abstract":[{"lang":"eng","text":"Many trace inequalities can be expressed either as concavity/convexity theorems or as monotonicity theorems. A classic example is the joint convexity of the quantum relative entropy which is equivalent to the Data Processing Inequality. The latter says that quantum operations can never increase the relative entropy. The monotonicity versions often have many advantages, and often have direct physical application, as in the example just mentioned. Moreover, the monotonicity results are often valid for a larger class of maps than, say, quantum operations (which are completely positive). In this paper we prove several new monotonicity results, the first of which is a monotonicity theorem that has as a simple corollary a celebrated concavity theorem of Epstein. Our starting points are the monotonicity versions of the Lieb Concavity and the Lieb Convexity Theorems. We also give two new proofs of these in their general forms using interpolation. We then prove our new monotonicity theorems by several duality arguments."}],"doi":"10.1016/j.laa.2022.09.001","title":"Monotonicity versions of Epstein's concavity theorem and related inequalities","author":[{"full_name":"Carlen, Eric A.","last_name":"Carlen","first_name":"Eric A."},{"id":"D8F41E38-9E66-11E9-A9E2-65C2E5697425","first_name":"Haonan","full_name":"Zhang, Haonan","last_name":"Zhang"}],"_id":"12216","publication_status":"published","status":"public","acknowledgement":"Work partially supported by the Lise Meitner fellowship, Austrian Science Fund (FWF) M3337.","publication_identifier":{"issn":["0024-3795"]},"project":[{"_id":"eb958bca-77a9-11ec-83b8-c565cb50d8d6","grant_number":"M03337","name":"Curvature-dimension in noncommutative analysis"}],"oa_version":"Published Version","citation":{"chicago":"Carlen, Eric A., and Haonan Zhang. “Monotonicity Versions of Epstein’s Concavity Theorem and Related Inequalities.” <i>Linear Algebra and Its Applications</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">https://doi.org/10.1016/j.laa.2022.09.001</a>.","mla":"Carlen, Eric A., and Haonan Zhang. “Monotonicity Versions of Epstein’s Concavity Theorem and Related Inequalities.” <i>Linear Algebra and Its Applications</i>, vol. 654, Elsevier, 2022, pp. 289–310, doi:<a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">10.1016/j.laa.2022.09.001</a>.","ieee":"E. A. Carlen and H. Zhang, “Monotonicity versions of Epstein’s concavity theorem and related inequalities,” <i>Linear Algebra and its Applications</i>, vol. 654. Elsevier, pp. 289–310, 2022.","apa":"Carlen, E. A., &#38; Zhang, H. (2022). Monotonicity versions of Epstein’s concavity theorem and related inequalities. <i>Linear Algebra and Its Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">https://doi.org/10.1016/j.laa.2022.09.001</a>","ama":"Carlen EA, Zhang H. Monotonicity versions of Epstein’s concavity theorem and related inequalities. <i>Linear Algebra and its Applications</i>. 2022;654:289-310. doi:<a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">10.1016/j.laa.2022.09.001</a>","short":"E.A. Carlen, H. Zhang, Linear Algebra and Its Applications 654 (2022) 289–310.","ista":"Carlen EA, Zhang H. 2022. Monotonicity versions of Epstein’s concavity theorem and related inequalities. Linear Algebra and its Applications. 654, 289–310."},"day":"01","month":"12","ddc":["510"],"file_date_updated":"2023-01-27T08:08:39Z","has_accepted_license":"1","volume":654,"article_processing_charge":"Yes (via OA deal)","file":[{"file_id":"12415","date_created":"2023-01-27T08:08:39Z","success":1,"date_updated":"2023-01-27T08:08:39Z","access_level":"open_access","content_type":"application/pdf","checksum":"cf3cb7e7e34baa967849f01d8f0c1ae4","file_name":"2022_LinearAlgebra_Carlen.pdf","creator":"dernst","file_size":441184,"relation":"main_file"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"project":[{"name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020","grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E"}],"publication_identifier":{"issn":["2041-1723"]},"ec_funded":1,"acknowledgement":"A.R.B. acknowledges the financial support of the European Research Council (ERC) through the funding of the grant Principles of Integrin Mechanics and Adhesion (PoINT) and the German Research Foundation (DFG, SFB 1032, project ID 201269156). E.H. was supported by the European Union (European Research Council Starting Grant 851288). D.S., M.R., and R.R. acknowledge the support by the German Research Foundation (DFG, SFB1321 Modeling and Targeting Pancreatic Cancer, Project S01, project ID 329628492). C.S. and M.R. acknowledge the support by the German Research Foundation (DFG, SFB1321 Modeling and Targeting Pancreatic Cancer, Project 12, project ID 329628492). M.R. was supported by the German Research Foundation (DFG RE 3723/4-1). A.P. and M.R. were supported by the German Cancer Aid (Max-Eder Program 111273 and 70114328).\r\nOpen Access funding enabled and organized by Projekt DEAL.","status":"public","publication_status":"published","_id":"12217","title":"Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids","author":[{"last_name":"Randriamanantsoa","full_name":"Randriamanantsoa, S.","first_name":"S."},{"first_name":"A.","last_name":"Papargyriou","full_name":"Papargyriou, A."},{"first_name":"H. C.","last_name":"Maurer","full_name":"Maurer, H. C."},{"first_name":"K.","last_name":"Peschke","full_name":"Peschke, K."},{"first_name":"M.","full_name":"Schuster, M.","last_name":"Schuster"},{"last_name":"Zecchin","full_name":"Zecchin, G.","first_name":"G."},{"full_name":"Steiger, K.","last_name":"Steiger","first_name":"K."},{"last_name":"Öllinger","full_name":"Öllinger, R.","first_name":"R."},{"first_name":"D.","last_name":"Saur","full_name":"Saur, D."},{"last_name":"Scheel","full_name":"Scheel, C.","first_name":"C."},{"full_name":"Rad, R.","last_name":"Rad","first_name":"R."},{"orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","full_name":"Hannezo, Edouard B","last_name":"Hannezo"},{"last_name":"Reichert","full_name":"Reichert, M.","first_name":"M."},{"last_name":"Bausch","full_name":"Bausch, A. R.","first_name":"A. R."}],"doi":"10.1038/s41467-022-32806-y","abstract":[{"text":"The development dynamics and self-organization of glandular branched epithelia is of utmost importance for our understanding of diverse processes ranging from normal tissue growth to the growth of cancerous tissues. Using single primary murine pancreatic ductal adenocarcinoma (PDAC) cells embedded in a collagen matrix and adapted media supplementation, we generate organoids that self-organize into highly branched structures displaying a seamless lumen connecting terminal end buds, replicating in vivo PDAC architecture. We identify distinct morphogenesis phases, each characterized by a unique pattern of cell invasion, matrix deformation, protein expression, and respective molecular dependencies. We propose a minimal theoretical model of a branching and proliferating tissue, capturing the dynamics of the first phases. Observing the interaction of morphogenesis, mechanical environment and gene expression in vitro sets a benchmark for the understanding of self-organization processes governing complex organoid structure formation processes and branching morphogenesis.","lang":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_id":"12416","date_created":"2023-01-27T08:14:48Z","success":1,"date_updated":"2023-01-27T08:14:48Z","access_level":"open_access","content_type":"application/pdf","checksum":"295261b5172274fd5b8f85a6a6058828","file_name":"2022_NatureCommunications_Randriamanantsoa.pdf","relation":"main_file","creator":"dernst","file_size":22645149}],"article_processing_charge":"No","volume":13,"has_accepted_license":"1","ddc":["570"],"month":"09","file_date_updated":"2023-01-27T08:14:48Z","citation":{"ama":"Randriamanantsoa S, Papargyriou A, Maurer HC, et al. Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-32806-y\">10.1038/s41467-022-32806-y</a>","short":"S. Randriamanantsoa, A. Papargyriou, H.C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E.B. Hannezo, M. Reichert, A.R. Bausch, Nature Communications 13 (2022).","ista":"Randriamanantsoa S, Papargyriou A, Maurer HC, Peschke K, Schuster M, Zecchin G, Steiger K, Öllinger R, Saur D, Scheel C, Rad R, Hannezo EB, Reichert M, Bausch AR. 2022. Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. Nature Communications. 13, 5219.","apa":"Randriamanantsoa, S., Papargyriou, A., Maurer, H. C., Peschke, K., Schuster, M., Zecchin, G., … Bausch, A. R. (2022). Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-32806-y\">https://doi.org/10.1038/s41467-022-32806-y</a>","ieee":"S. Randriamanantsoa <i>et al.</i>, “Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","mla":"Randriamanantsoa, S., et al. “Spatiotemporal Dynamics of Self-Organized Branching in Pancreas-Derived Organoids.” <i>Nature Communications</i>, vol. 13, 5219, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-32806-y\">10.1038/s41467-022-32806-y</a>.","chicago":"Randriamanantsoa, S., A. Papargyriou, H. C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, et al. “Spatiotemporal Dynamics of Self-Organized Branching in Pancreas-Derived Organoids.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-32806-y\">https://doi.org/10.1038/s41467-022-32806-y</a>."},"day":"05","oa_version":"Published Version","date_updated":"2023-08-04T09:25:23Z","publication":"Nature Communications","article_number":"5219","article_type":"original","related_material":{"record":[{"status":"public","relation":"research_data","id":"13068"}]},"oa":1,"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"year":"2022","publisher":"Springer Nature","intvolume":"        13","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"EdHa"}],"date_created":"2023-01-16T09:46:53Z","scopus_import":"1","date_published":"2022-09-05T00:00:00Z","external_id":{"isi":["000850348400025"]}},{"oa_version":"Published Version","citation":{"apa":"Currin, C., Vera, S. V., &#38; Khaledi-Nasab, A. (2022). Depolarization of echo chambers by random dynamical nudge. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-022-12494-w\">https://doi.org/10.1038/s41598-022-12494-w</a>","ieee":"C. Currin, S. V. Vera, and A. Khaledi-Nasab, “Depolarization of echo chambers by random dynamical nudge,” <i>Scientific Reports</i>, vol. 12. Springer Nature, 2022.","ama":"Currin C, Vera SV, Khaledi-Nasab A. Depolarization of echo chambers by random dynamical nudge. <i>Scientific Reports</i>. 2022;12. doi:<a href=\"https://doi.org/10.1038/s41598-022-12494-w\">10.1038/s41598-022-12494-w</a>","ista":"Currin C, Vera SV, Khaledi-Nasab A. 2022. Depolarization of echo chambers by random dynamical nudge. Scientific Reports. 12, 9234.","short":"C. Currin, S.V. Vera, A. Khaledi-Nasab, Scientific Reports 12 (2022).","mla":"Currin, Christopher, et al. “Depolarization of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>, vol. 12, 9234, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41598-022-12494-w\">10.1038/s41598-022-12494-w</a>.","chicago":"Currin, Christopher, Sebastián Vallejo Vera, and Ali Khaledi-Nasab. “Depolarization of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41598-022-12494-w\">https://doi.org/10.1038/s41598-022-12494-w</a>."},"day":"02","file_date_updated":"2023-01-27T08:56:18Z","pmid":1,"ddc":["570"],"month":"06","has_accepted_license":"1","article_processing_charge":"No","volume":12,"file":[{"file_name":"2022_ScientificReports_Currin.pdf","file_size":3625627,"creator":"dernst","relation":"main_file","access_level":"open_access","content_type":"application/pdf","checksum":"e024a75f14ce5667795a31e44a259c52","success":1,"date_updated":"2023-01-27T08:56:18Z","file_id":"12418","date_created":"2023-01-27T08:56:18Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"abstract":[{"lang":"eng","text":"In social networks, users often engage with like-minded peers. This selective exposure to opinions might result in echo chambers, i.e., political fragmentation and social polarization of user interactions. When echo chambers form, opinions have a bimodal distribution with two peaks on opposite sides. In certain issues, where either extreme positions contain a degree of misinformation, neutral consensus is preferable for promoting discourse. In this paper, we use an opinion dynamics model that naturally forms echo chambers in order to find a feedback mechanism that bridges these communities and leads to a neutral consensus. We introduce the <jats:italic>random dynamical nudge</jats:italic> (RDN), which presents each agent with input from a random selection of other agents’ opinions and does not require surveillance of every person’s opinions. Our computational results in two different models suggest that the RDN leads to a unimodal distribution of opinions centered around the neutral consensus. Furthermore, the RDN is effective both for preventing the formation of echo chambers and also for depolarizing existing echo chambers. Due to the simple and robust nature of the RDN, social media networks might be able to implement a version of this self-feedback mechanism, when appropriate, to prevent the segregation of online communities on complex social issues."}],"doi":"10.1038/s41598-022-12494-w","title":"Depolarization of echo chambers by random dynamical nudge","author":[{"orcid":"0000-0002-4809-5059","last_name":"Currin","full_name":"Currin, Christopher","first_name":"Christopher","id":"e8321fc5-3091-11eb-8a53-83f309a11ac9"},{"first_name":"Sebastián Vallejo","last_name":"Vera","full_name":"Vera, Sebastián Vallejo"},{"full_name":"Khaledi-Nasab, Ali","last_name":"Khaledi-Nasab","first_name":"Ali"}],"_id":"12225","acknowledgement":"CBC and AKN would like to thank Neuromatch Academy https://www.neuromatchacademy.org for introducing the authors to each other. We thank Dr. Krešimir Josic (University of Houston) , Fabian Baumann (Humboldt University) and Dr. Igor M. Sokolov (Humboldt University) for carefully reading the early versions of the manuscript and providing constructive feedback. CBC is supported by the German Deutscher Akademischer Austauschdienst (DAAD, https://daad.de), the South African National Research Foundation (NRF, https://nrf.ac.za), the University of Cape Town (UCT, https://uct.ac.za), and the NOMIS Foundation through the NOMIS Fellowships at IST Austria program (https://nomisfoundation.ch). SVV appreciate the generosity of Tecnológico de Monterrey for covering the publication fee.","publication_status":"published","status":"public","publication_identifier":{"issn":["2045-2322"]},"date_published":"2022-06-02T00:00:00Z","external_id":{"isi":["000805561200024"],"pmid":["35654942"]},"date_created":"2023-01-16T09:48:30Z","scopus_import":"1","department":[{"_id":"TiVo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"Springer Nature","intvolume":"        12","year":"2022","keyword":["Multidisciplinary"],"oa":1,"article_number":"9234","article_type":"original","publication":"Scientific Reports","date_updated":"2023-08-04T09:26:30Z"},{"publication_identifier":{"issn":["1474-760X"]},"project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"status":"public","acknowledgement":"We acknowledge the financial support of the Natural Sciences and Engineering Research Council of Canada (NSERC RGPIN-2020-06377), the Spanish Ministry of Economy, Industry and Competitiveness (“Centro de Excelencia Severo Ochoa 2013-2017”, Plan Estatal PGC2018-099807-B-I00), of the CERCA Programme/Generalitat de Catalunya, and of the European Research Council (Synergy Grant 609989). VOP was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie programme (665385). We also acknowledge the support of the Spanish Ministry of Economy and Competitiveness (MEIC) to the EMBL partnership.","publication_status":"published","ec_funded":1,"author":[{"orcid":"0000-0001-7660-444X","first_name":"Victoria","id":"3184041C-F248-11E8-B48F-1D18A9856A87","last_name":"Pokusaeva","full_name":"Pokusaeva, Victoria"},{"first_name":"Aránzazu Rosado","full_name":"Diez, Aránzazu Rosado","last_name":"Diez"},{"full_name":"Espinar, Lorena","last_name":"Espinar","first_name":"Lorena"},{"first_name":"Albert Torelló","last_name":"Pérez","full_name":"Pérez, Albert Torelló"},{"last_name":"Filion","full_name":"Filion, Guillaume J.","first_name":"Guillaume J."}],"title":"Strand asymmetry influences mismatch resolution during single-strand annealing","_id":"12226","abstract":[{"text":"Background: Biases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are still poorly understood because it is difficult to isolate the contributions of DNA repair from those of DNA damage.\r\n\r\nResults: Here, we develop a genome-wide assay whereby the same DNA lesion is repaired in different genomic contexts. We insert thousands of barcoded transposons carrying a reporter of DNA mismatch repair in the genome of mouse embryonic stem cells. Upon inducing a double-strand break between tandem repeats, a mismatch is generated if the break is repaired through single-strand annealing. The resolution of the mismatch showed a 60–80% bias in favor of the strand with the longest 3′ flap. The location of the lesion in the genome and the type of mismatch had little influence on the bias. Instead, we observe a complete reversal of the bias when the longest 3′ flap is moved to the opposite strand by changing the position of the double-strand break in the reporter.\r\n\r\nConclusions: These results suggest that the processing of the double-strand break has a major influence on the repair of mismatches during single-strand annealing.","lang":"eng"}],"doi":"10.1186/s13059-022-02665-3","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T09:01:40Z","file_id":"12419","creator":"dernst","relation":"main_file","file_size":4939342,"file_name":"2022_GenomeBiology_Pokusaeva.pdf","date_updated":"2023-01-27T09:01:40Z","success":1,"content_type":"application/pdf","checksum":"17bb091fec04d82ba20a3458c4cfd2bd","access_level":"open_access"}],"has_accepted_license":"1","article_processing_charge":"No","volume":23,"day":"12","citation":{"short":"V. Pokusaeva, A.R. Diez, L. Espinar, A.T. Pérez, G.J. Filion, Genome Biology 23 (2022).","ama":"Pokusaeva V, Diez AR, Espinar L, Pérez AT, Filion GJ. Strand asymmetry influences mismatch resolution during single-strand annealing. <i>Genome Biology</i>. 2022;23. doi:<a href=\"https://doi.org/10.1186/s13059-022-02665-3\">10.1186/s13059-022-02665-3</a>","ista":"Pokusaeva V, Diez AR, Espinar L, Pérez AT, Filion GJ. 2022. Strand asymmetry influences mismatch resolution during single-strand annealing. Genome Biology. 23, 93.","apa":"Pokusaeva, V., Diez, A. R., Espinar, L., Pérez, A. T., &#38; Filion, G. J. (2022). Strand asymmetry influences mismatch resolution during single-strand annealing. <i>Genome Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13059-022-02665-3\">https://doi.org/10.1186/s13059-022-02665-3</a>","ieee":"V. Pokusaeva, A. R. Diez, L. Espinar, A. T. Pérez, and G. J. Filion, “Strand asymmetry influences mismatch resolution during single-strand annealing,” <i>Genome Biology</i>, vol. 23. Springer Nature, 2022.","chicago":"Pokusaeva, Victoria, Aránzazu Rosado Diez, Lorena Espinar, Albert Torelló Pérez, and Guillaume J. Filion. “Strand Asymmetry Influences Mismatch Resolution during Single-Strand Annealing.” <i>Genome Biology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1186/s13059-022-02665-3\">https://doi.org/10.1186/s13059-022-02665-3</a>.","mla":"Pokusaeva, Victoria, et al. “Strand Asymmetry Influences Mismatch Resolution during Single-Strand Annealing.” <i>Genome Biology</i>, vol. 23, 93, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1186/s13059-022-02665-3\">10.1186/s13059-022-02665-3</a>."},"month":"04","pmid":1,"file_date_updated":"2023-01-27T09:01:40Z","ddc":["570"],"oa_version":"Published Version","publication":"Genome Biology","date_updated":"2023-08-04T09:27:00Z","related_material":{"link":[{"relation":"software","url":"https://github.com/cellcomplexitylab/strand_asymmetry "},{"relation":"software","url":"https://hub.docker.com/r/gui11aume/strand_asymmetry"}]},"article_type":"original","article_number":"93","oa":1,"year":"2022","intvolume":"        23","publisher":"Springer Nature","isi":1,"quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","department":[{"_id":"MaJö"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2022-04-12T00:00:00Z","external_id":{"isi":["000781953800001"],"pmid":["35414014"]},"scopus_import":"1","date_created":"2023-01-16T09:48:44Z"},{"date_updated":"2023-08-04T09:27:32Z","publication":"ACS Applied Energy Materials","article_type":"original","page":"14381-14390","oa":1,"keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"year":"2022","intvolume":"         5","publisher":"American Chemical Society","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"StFr"}],"scopus_import":"1","date_created":"2023-01-16T09:48:53Z","external_id":{"isi":["000875635900001"]},"date_published":"2022-10-16T00:00:00Z","publication_identifier":{"issn":["2574-0962"]},"publication_status":"published","status":"public","acknowledgement":"S.K. acknowledges the financial support from the Slovenian Research Agency (grants P1-0021, P2-0150). Support by Graz University of Technology (LP-03 – Porous Materials@Work) and from VARTA Innovation GmbH is kindly acknowledged. We thank Umicore for providing the initiator and Matjaž Mazaj (National Institute of Chemistry, Ljubljana) and Karel Jerabek (Czech Academy of Sciences) for measurements and fruitful discussions. S.A.F. is indebted to the Austrian Federal Ministry of Science, Research and Economy; the Austrian Research Promotion Agency (Grant No. 845364); and ISTA for support.","_id":"12227","author":[{"first_name":"Sebastijan","full_name":"Kovačič, Sebastijan","last_name":"Kovačič"},{"first_name":"Bettina","full_name":"Schafzahl, Bettina","last_name":"Schafzahl"},{"first_name":"Nadejda B.","last_name":"Matsko","full_name":"Matsko, Nadejda B."},{"full_name":"Gruber, Katharina","last_name":"Gruber","first_name":"Katharina"},{"first_name":"Martin","full_name":"Schmuck, Martin","last_name":"Schmuck"},{"first_name":"Stefan","last_name":"Koller","full_name":"Koller, Stefan"},{"orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander"},{"last_name":"Slugovc","full_name":"Slugovc, Christian","first_name":"Christian"}],"title":"Carbon foams via ring-opening metathesis polymerization of emulsion templates: A facile method to make carbon current collectors for battery applications","doi":"10.1021/acsaem.2c02787","issue":"11","abstract":[{"text":"Polydicyclopentadiene (pDCPD), a thermoset with excellent mechanical properties, has enormous potential as a lightweight, tough, and stable matrix material owing to its highly cross-linked macromolecular network. This work describes generating pDCPD-based foams and hierarchically porous carbons derived therefrom by combining ring-opening metathesis polymerization (ROMP) of DCPD, high internal phase emulsions (HIPEs) as structural templates, and subsequent carbonization. The structure and function of the carbon foams were characterized and discussed in detail using scanning electron, transmission electron, or atomic force microscopy (SEM, TEM, AFM), electron energy-loss spectroscopy (TEM-EELS), N2 sorption, and analyses of electrical conductivity as well as mechanical properties. The resulting materials exhibited uniform, shape-retaining shrinkage of only ∼1/3 after carbonization. No structural failure was observed even when the pDCPD precursor foams were heated to 1400 °C. Instead, the high porosity, void size, and 3D interconnectivity were fully preserved, and the void diameters could be adjusted between 87 and 2.5 μm. Moreover, foams have a carbon content >97%, an electronic conductivity of up to 2800 S·m–1, a Young’s modulus of up to 2.1 GPa, and a specific surface area of up to 1200 m2·g–1. Surprisingly, the pDCPD foams were carbonized into shapes other than monoliths, such as 10’s of micron thick membranes or foamy coatings adhered to a metal foil or grid substrate. The latter coatings even adhere upon bending. Finally, as a use case, carbonized foams were applied as porous cathodes for Li–O2 batteries where the foams show a favorable combination of porosity, active surface area, and pore size for outstanding capacity.","lang":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_id":"12420","date_created":"2023-01-27T09:09:15Z","access_level":"open_access","checksum":"572d15c250ab83d44f4e2c3aeb5f7388","content_type":"application/pdf","success":1,"date_updated":"2023-01-27T09:09:15Z","file_name":"2022_AppliedEnergyMaterials_Kovacic.pdf","file_size":13105589,"creator":"dernst","relation":"main_file"}],"article_processing_charge":"No","volume":5,"has_accepted_license":"1","month":"10","ddc":["540"],"file_date_updated":"2023-01-27T09:09:15Z","day":"16","citation":{"apa":"Kovačič, S., Schafzahl, B., Matsko, N. B., Gruber, K., Schmuck, M., Koller, S., … Slugovc, C. (2022). Carbon foams via ring-opening metathesis polymerization of emulsion templates: A facile method to make carbon current collectors for battery applications. <i>ACS Applied Energy Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsaem.2c02787\">https://doi.org/10.1021/acsaem.2c02787</a>","ieee":"S. Kovačič <i>et al.</i>, “Carbon foams via ring-opening metathesis polymerization of emulsion templates: A facile method to make carbon current collectors for battery applications,” <i>ACS Applied Energy Materials</i>, vol. 5, no. 11. American Chemical Society, pp. 14381–14390, 2022.","ista":"Kovačič S, Schafzahl B, Matsko NB, Gruber K, Schmuck M, Koller S, Freunberger SA, Slugovc C. 2022. Carbon foams via ring-opening metathesis polymerization of emulsion templates: A facile method to make carbon current collectors for battery applications. ACS Applied Energy Materials. 5(11), 14381–14390.","ama":"Kovačič S, Schafzahl B, Matsko NB, et al. Carbon foams via ring-opening metathesis polymerization of emulsion templates: A facile method to make carbon current collectors for battery applications. <i>ACS Applied Energy Materials</i>. 2022;5(11):14381-14390. doi:<a href=\"https://doi.org/10.1021/acsaem.2c02787\">10.1021/acsaem.2c02787</a>","short":"S. Kovačič, B. Schafzahl, N.B. Matsko, K. Gruber, M. Schmuck, S. Koller, S.A. Freunberger, C. Slugovc, ACS Applied Energy Materials 5 (2022) 14381–14390.","mla":"Kovačič, Sebastijan, et al. “Carbon Foams via Ring-Opening Metathesis Polymerization of Emulsion Templates: A Facile Method to Make Carbon Current Collectors for Battery Applications.” <i>ACS Applied Energy Materials</i>, vol. 5, no. 11, American Chemical Society, 2022, pp. 14381–90, doi:<a href=\"https://doi.org/10.1021/acsaem.2c02787\">10.1021/acsaem.2c02787</a>.","chicago":"Kovačič, Sebastijan, Bettina Schafzahl, Nadejda B. Matsko, Katharina Gruber, Martin Schmuck, Stefan Koller, Stefan Alexander Freunberger, and Christian Slugovc. “Carbon Foams via Ring-Opening Metathesis Polymerization of Emulsion Templates: A Facile Method to Make Carbon Current Collectors for Battery Applications.” <i>ACS Applied Energy Materials</i>. American Chemical Society, 2022. <a href=\"https://doi.org/10.1021/acsaem.2c02787\">https://doi.org/10.1021/acsaem.2c02787</a>."},"oa_version":"Published Version"},{"author":[{"last_name":"Spiegelman","full_name":"Spiegelman, Alexander","first_name":"Alexander"},{"full_name":"Giridharan, Neil","last_name":"Giridharan","first_name":"Neil"},{"last_name":"Sonnino","full_name":"Sonnino, Alberto","first_name":"Alberto"},{"first_name":"Eleftherios","id":"f5983044-d7ef-11ea-ac6d-fd1430a26d30","last_name":"Kokoris Kogias","full_name":"Kokoris Kogias, Eleftherios"}],"title":"Bullshark: DAG BFT protocols made practical","_id":"12229","abstract":[{"lang":"eng","text":"We present Bullshark, the first directed acyclic graph (DAG) based asynchronous Byzantine Atomic Broadcast protocol that is optimized for the common synchronous case. Like previous DAG-based BFT protocols [19, 25], Bullshark requires no extra communication to achieve consensus on top of building the DAG. That is, parties can totally order the vertices of the DAG by interpreting their local view of the DAG edges. Unlike other asynchronous DAG-based protocols, Bullshark provides a practical low latency fast-path that exploits synchronous periods and deprecates the need for notoriously complex view-change and view-synchronization mechanisms. Bullshark achieves this while maintaining all the desired properties of its predecessor DAG-Rider [25]. Namely, it has optimal amortized communication complexity, it provides fairness and asynchronous liveness, and safety is guaranteed even under a quantum adversary.\r\n\r\nIn order to show the practicality and simplicity of our approach, we also introduce a standalone partially synchronous version of Bullshark, which we evaluate against the state of the art. The implemented protocol is embarrassingly simple (200 LOC on top of an existing DAG-based mempool implementation). It is highly efficient, achieving for example, 125,000 transactions per second with a 2 seconds latency for a deployment of 50 parties. In the same setting, the state of the art pays a steep 50% latency increase as it optimizes for asynchrony."}],"doi":"10.1145/3548606.3559361","publication_identifier":{"isbn":["9781450394505"]},"status":"public","publication_status":"published","day":"01","citation":{"chicago":"Spiegelman, Alexander, Neil Giridharan, Alberto Sonnino, and Eleftherios Kokoris Kogias. “Bullshark: DAG BFT Protocols Made Practical.” In <i>Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security</i>, 2705–2718. Association for Computing Machinery, 2022. <a href=\"https://doi.org/10.1145/3548606.3559361\">https://doi.org/10.1145/3548606.3559361</a>.","mla":"Spiegelman, Alexander, et al. “Bullshark: DAG BFT Protocols Made Practical.” <i>Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security</i>, Association for Computing Machinery, 2022, pp. 2705–2718, doi:<a href=\"https://doi.org/10.1145/3548606.3559361\">10.1145/3548606.3559361</a>.","ama":"Spiegelman A, Giridharan N, Sonnino A, Kokoris Kogias E. Bullshark: DAG BFT protocols made practical. In: <i>Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security</i>. Association for Computing Machinery; 2022:2705–2718. doi:<a href=\"https://doi.org/10.1145/3548606.3559361\">10.1145/3548606.3559361</a>","short":"A. Spiegelman, N. Giridharan, A. Sonnino, E. Kokoris Kogias, in:, Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security, Association for Computing Machinery, 2022, pp. 2705–2718.","ista":"Spiegelman A, Giridharan N, Sonnino A, Kokoris Kogias E. 2022. Bullshark: DAG BFT protocols made practical. Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security. CCS: CConference on Computer and Communications Security, 2705–2718.","apa":"Spiegelman, A., Giridharan, N., Sonnino, A., &#38; Kokoris Kogias, E. (2022). Bullshark: DAG BFT protocols made practical. In <i>Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security</i> (pp. 2705–2718). Los Angeles, CA, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3548606.3559361\">https://doi.org/10.1145/3548606.3559361</a>","ieee":"A. Spiegelman, N. Giridharan, A. Sonnino, and E. Kokoris Kogias, “Bullshark: DAG BFT protocols made practical,” in <i>Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security</i>, Los Angeles, CA, United States, 2022, pp. 2705–2718."},"month":"11","conference":{"end_date":"2022-11-11","location":"Los Angeles, CA, United States","start_date":"2022-11-07","name":"CCS: CConference on Computer and Communications Security"},"oa_version":"Preprint","arxiv":1,"article_processing_charge":"No","oa":1,"year":"2022","publication":"Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security","date_updated":"2023-01-27T10:33:17Z","page":"2705–2718","department":[{"_id":"ElKo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2201.05677"]},"date_published":"2022-11-01T00:00:00Z","scopus_import":"1","date_created":"2023-01-16T09:49:48Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2201.05677"}],"publisher":"Association for Computing Machinery","language":[{"iso":"eng"}],"quality_controlled":"1","type":"conference"},{"oa_version":"Published Version","pmid":1,"month":"11","file_date_updated":"2023-01-27T10:36:50Z","ddc":["570"],"citation":{"chicago":"Kogure, Yuki S., Hiromochi Muraoka, Wataru C. Koizumi, Raphaël Gelin-alessi, Benoit G Godard, Kotaro Oka, Carl-Philipp J Heisenberg, and Kohji Hotta. “Admp Regulates Tail Bending by Controlling Ventral Epidermal Cell Polarity via Phosphorylated Myosin Localization in Ciona.” <i>Development</i>. The Company of Biologists, 2022. <a href=\"https://doi.org/10.1242/dev.200215\">https://doi.org/10.1242/dev.200215</a>.","mla":"Kogure, Yuki S., et al. “Admp Regulates Tail Bending by Controlling Ventral Epidermal Cell Polarity via Phosphorylated Myosin Localization in Ciona.” <i>Development</i>, vol. 149, no. 21, dev200215, The Company of Biologists, 2022, doi:<a href=\"https://doi.org/10.1242/dev.200215\">10.1242/dev.200215</a>.","ieee":"Y. S. Kogure <i>et al.</i>, “Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona,” <i>Development</i>, vol. 149, no. 21. The Company of Biologists, 2022.","apa":"Kogure, Y. S., Muraoka, H., Koizumi, W. C., Gelin-alessi, R., Godard, B. G., Oka, K., … Hotta, K. (2022). Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona. <i>Development</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/dev.200215\">https://doi.org/10.1242/dev.200215</a>","short":"Y.S. Kogure, H. Muraoka, W.C. Koizumi, R. Gelin-alessi, B.G. Godard, K. Oka, C.-P.J. Heisenberg, K. Hotta, Development 149 (2022).","ama":"Kogure YS, Muraoka H, Koizumi WC, et al. Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona. <i>Development</i>. 2022;149(21). doi:<a href=\"https://doi.org/10.1242/dev.200215\">10.1242/dev.200215</a>","ista":"Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard BG, Oka K, Heisenberg C-PJ, Hotta K. 2022. Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona. Development. 149(21), dev200215."},"day":"01","volume":149,"article_processing_charge":"No","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T10:36:50Z","file_id":"12423","file_size":9160451,"relation":"main_file","creator":"dernst","file_name":"2022_Development_Kogure.pdf","checksum":"871b9c58eb79b9e60752de25a46938d6","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-27T10:36:50Z","success":1}],"doi":"10.1242/dev.200215","abstract":[{"lang":"eng","text":"Ventral tail bending, which is transient but pronounced, is found in many chordate embryos and constitutes an interesting model of how tissue interactions control embryo shape. Here, we identify one key upstream regulator of ventral tail bending in embryos of the ascidian Ciona. We show that during the early tailbud stages, ventral epidermal cells exhibit a boat-shaped morphology (boat cell) with a narrow apical surface where phosphorylated myosin light chain (pMLC) accumulates. We further show that interfering with the function of the BMP ligand Admp led to pMLC localizing to the basal instead of the apical side of ventral epidermal cells and a reduced number of boat cells. Finally, we show that cutting ventral epidermal midline cells at their apex using an ultraviolet laser relaxed ventral tail bending. Based on these results, we propose a previously unreported function for Admp in localizing pMLC to the apical side of ventral epidermal cells, which causes the tail to bend ventrally by resisting antero-posterior notochord extension at the ventral side of the tail."}],"issue":"21","_id":"12231","title":"Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona","author":[{"first_name":"Yuki S.","full_name":"Kogure, Yuki S.","last_name":"Kogure"},{"last_name":"Muraoka","full_name":"Muraoka, Hiromochi","first_name":"Hiromochi"},{"first_name":"Wataru C.","full_name":"Koizumi, Wataru C.","last_name":"Koizumi"},{"full_name":"Gelin-alessi, Raphaël","last_name":"Gelin-alessi","first_name":"Raphaël"},{"full_name":"Godard, Benoit G","last_name":"Godard","id":"3263621A-F248-11E8-B48F-1D18A9856A87","first_name":"Benoit G"},{"full_name":"Oka, Kotaro","last_name":"Oka","first_name":"Kotaro"},{"last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"first_name":"Kohji","last_name":"Hotta","full_name":"Hotta, Kohji"}],"acknowledgement":"iona intestinalis adults were provided by Dr Yutaka Satou (Kyoto University) and Dr Manabu Yoshida (the University of Tokyo) with support from the National Bio-Resource Project of AMED, Japan. We thank Dr Hidehiko Hashimoto and Dr Yuji Mizotani for technical information about 1P-myosin antibody staining. We thank Dr Kaoru Imai and Dr Yutaka Satou for valuable discussion about Admp and for the DNA construct of Bmp2/4 under the Dlx.b upstream sequence. We thank Ms Maki Kogure for constructing the FUSION360 of the intercalating epidermal cell.\r\nThis work was supported by funding from the Japan Society for the Promotion of Science (JP16H01451, JP21H00440). Open Access funding provided by Keio University: Keio Gijuku Daigaku.","publication_status":"published","status":"public","publication_identifier":{"issn":["0950-1991"],"eissn":["1477-9129"]},"date_created":"2023-01-16T09:50:12Z","scopus_import":"1","date_published":"2022-11-01T00:00:00Z","external_id":{"isi":["000903991700002"],"pmid":["36227591"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"CaHe"}],"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","isi":1,"publisher":"The Company of Biologists","intvolume":"       149","keyword":["Developmental Biology","Molecular Biology"],"year":"2022","oa":1,"article_number":"dev200215","article_type":"original","date_updated":"2023-08-04T09:33:24Z","publication":"Development"},{"status":"public","acknowledgement":"Open access funding provided by Swiss Federal Institute of Technology Zurich. Supported by Dr. Max Rössler, the Walter Haefner Foundation and the ETH Zürich Foundation.","publication_status":"published","publication_identifier":{"issn":["1424-0637"],"eissn":["1424-0661"]},"doi":"10.1007/s00023-022-01188-8","abstract":[{"text":"We derive a precise asymptotic formula for the density of the small singular values of the real Ginibre matrix ensemble shifted by a complex parameter z as the dimension tends to infinity. For z away from the real axis the formula coincides with that for the complex Ginibre ensemble we derived earlier in Cipolloni et al. (Prob Math Phys 1:101–146, 2020). On the level of the one-point function of the low lying singular values we thus confirm the transition from real to complex Ginibre ensembles as the shift parameter z becomes genuinely complex; the analogous phenomenon has been well known for eigenvalues. We use the superbosonization formula (Littelmann et al. in Comm Math Phys 283:343–395, 2008) in a regime where the main contribution comes from a three dimensional saddle manifold.","lang":"eng"}],"issue":"11","_id":"12232","title":"Density of small singular values of the shifted real Ginibre ensemble","author":[{"orcid":"0000-0002-4901-7992","full_name":"Cipolloni, Giorgio","last_name":"Cipolloni","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","first_name":"Giorgio"},{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","full_name":"Erdös, László","orcid":"0000-0001-5366-9603"},{"orcid":"0000-0002-2904-1856","id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J","full_name":"Schröder, Dominik J","last_name":"Schröder"}],"article_processing_charge":"No","volume":23,"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T11:06:47Z","file_id":"12424","date_updated":"2023-01-27T11:06:47Z","success":1,"content_type":"application/pdf","checksum":"5582f059feeb2f63e2eb68197a34d7dc","access_level":"open_access","relation":"main_file","creator":"dernst","file_size":1333638,"file_name":"2022_AnnalesHenriP_Cipolloni.pdf"}],"oa_version":"Published Version","month":"11","ddc":["510"],"file_date_updated":"2023-01-27T11:06:47Z","citation":{"ama":"Cipolloni G, Erdös L, Schröder DJ. Density of small singular values of the shifted real Ginibre ensemble. <i>Annales Henri Poincaré</i>. 2022;23(11):3981-4002. doi:<a href=\"https://doi.org/10.1007/s00023-022-01188-8\">10.1007/s00023-022-01188-8</a>","ista":"Cipolloni G, Erdös L, Schröder DJ. 2022. Density of small singular values of the shifted real Ginibre ensemble. Annales Henri Poincaré. 23(11), 3981–4002.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Annales Henri Poincaré 23 (2022) 3981–4002.","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Density of small singular values of the shifted real Ginibre ensemble,” <i>Annales Henri Poincaré</i>, vol. 23, no. 11. Springer Nature, pp. 3981–4002, 2022.","apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2022). Density of small singular values of the shifted real Ginibre ensemble. <i>Annales Henri Poincaré</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00023-022-01188-8\">https://doi.org/10.1007/s00023-022-01188-8</a>","mla":"Cipolloni, Giorgio, et al. “Density of Small Singular Values of the Shifted Real Ginibre Ensemble.” <i>Annales Henri Poincaré</i>, vol. 23, no. 11, Springer Nature, 2022, pp. 3981–4002, doi:<a href=\"https://doi.org/10.1007/s00023-022-01188-8\">10.1007/s00023-022-01188-8</a>.","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Density of Small Singular Values of the Shifted Real Ginibre Ensemble.” <i>Annales Henri Poincaré</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00023-022-01188-8\">https://doi.org/10.1007/s00023-022-01188-8</a>."},"day":"01","page":"3981-4002","article_type":"original","date_updated":"2023-08-04T09:33:52Z","publication":"Annales Henri Poincaré","keyword":["Mathematical Physics","Nuclear and High Energy Physics","Statistical and Nonlinear Physics"],"year":"2022","oa":1,"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"isi":1,"publisher":"Springer Nature","intvolume":"        23","date_created":"2023-01-16T09:50:26Z","scopus_import":"1","date_published":"2022-11-01T00:00:00Z","external_id":{"isi":["000796323500001"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"LaEr"}]},{"year":"2022","oa":1,"page":"7134-7145","article_type":"original","publication":"IEEE Transactions on Communications","date_updated":"2023-08-04T09:34:43Z","date_published":"2022-11-01T00:00:00Z","external_id":{"isi":["000937284600006"],"arxiv":["2109.02122"]},"date_created":"2023-01-16T09:50:38Z","scopus_import":"1","department":[{"_id":"MaMo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","publisher":"Institute of Electrical and Electronics Engineers","intvolume":"        70","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2109.02122"}],"abstract":[{"lang":"eng","text":"A novel recursive list decoding (RLD) algorithm for Reed-Muller (RM) codes based on successive permutations (SP) of the codeword is presented. A low-complexity SP scheme applied to a subset of the symmetry group of RM codes is first proposed to carefully select a good codeword permutation on the fly. Then, the proposed SP technique is integrated into an improved RLD algorithm that initializes different decoding paths with random codeword permutations, which are sampled from the full symmetry group of RM codes. Finally, efficient latency and complexity reduction schemes are introduced that virtually preserve the error-correction performance of the proposed decoder. Simulation results demonstrate that at the target frame error rate of 10−3 for the RM code of length 256 with 163 information bits, the proposed decoder reduces 6% of the computational complexity and 22% of the decoding latency of the state-of-the-art semi-parallel simplified successive-cancellation decoder with fast Hadamard transform (SSC-FHT) that uses 96 permutations from the full symmetry group of RM codes, while relatively maintaining the error-correction performance and memory consumption of the semi-parallel permuted SSC-FHT decoder."}],"issue":"11","doi":"10.1109/tcomm.2022.3211101","title":"Decoding Reed-Muller codes with successive codeword permutations","author":[{"last_name":"Doan","full_name":"Doan, Nghia","first_name":"Nghia"},{"first_name":"Seyyed Ali","last_name":"Hashemi","full_name":"Hashemi, Seyyed Ali"},{"last_name":"Mondelli","full_name":"Mondelli, Marco","first_name":"Marco","id":"27EB676C-8706-11E9-9510-7717E6697425","orcid":"0000-0002-3242-7020"},{"full_name":"Gross, Warren J.","last_name":"Gross","first_name":"Warren J."}],"_id":"12233","status":"public","publication_status":"published","publication_identifier":{"issn":["0090-6778"],"eissn":["1558-0857"]},"oa_version":"Preprint","citation":{"chicago":"Doan, Nghia, Seyyed Ali Hashemi, Marco Mondelli, and Warren J. Gross. “Decoding Reed-Muller Codes with Successive Codeword Permutations.” <i>IEEE Transactions on Communications</i>. Institute of Electrical and Electronics Engineers, 2022. <a href=\"https://doi.org/10.1109/tcomm.2022.3211101\">https://doi.org/10.1109/tcomm.2022.3211101</a>.","mla":"Doan, Nghia, et al. “Decoding Reed-Muller Codes with Successive Codeword Permutations.” <i>IEEE Transactions on Communications</i>, vol. 70, no. 11, Institute of Electrical and Electronics Engineers, 2022, pp. 7134–45, doi:<a href=\"https://doi.org/10.1109/tcomm.2022.3211101\">10.1109/tcomm.2022.3211101</a>.","apa":"Doan, N., Hashemi, S. A., Mondelli, M., &#38; Gross, W. J. (2022). Decoding Reed-Muller codes with successive codeword permutations. <i>IEEE Transactions on Communications</i>. Institute of Electrical and Electronics Engineers. <a href=\"https://doi.org/10.1109/tcomm.2022.3211101\">https://doi.org/10.1109/tcomm.2022.3211101</a>","ieee":"N. Doan, S. A. Hashemi, M. Mondelli, and W. J. Gross, “Decoding Reed-Muller codes with successive codeword permutations,” <i>IEEE Transactions on Communications</i>, vol. 70, no. 11. Institute of Electrical and Electronics Engineers, pp. 7134–7145, 2022.","ama":"Doan N, Hashemi SA, Mondelli M, Gross WJ. Decoding Reed-Muller codes with successive codeword permutations. <i>IEEE Transactions on Communications</i>. 2022;70(11):7134-7145. doi:<a href=\"https://doi.org/10.1109/tcomm.2022.3211101\">10.1109/tcomm.2022.3211101</a>","ista":"Doan N, Hashemi SA, Mondelli M, Gross WJ. 2022. Decoding Reed-Muller codes with successive codeword permutations. IEEE Transactions on Communications. 70(11), 7134–7145.","short":"N. Doan, S.A. Hashemi, M. Mondelli, W.J. Gross, IEEE Transactions on Communications 70 (2022) 7134–7145."},"day":"01","month":"11","article_processing_charge":"No","volume":70,"arxiv":1},{"_id":"12234","author":[{"full_name":"Stankowski, Sean","last_name":"Stankowski","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean"}],"title":"Digest: On the origin of a possible hybrid species","doi":"10.1111/evo.14632","issue":"11","abstract":[{"text":"Hybrid speciation—the origin of new species resulting from the hybridization of genetically divergent lineages—was once considered rare, but genomic data suggest that it may occur more often than once thought. In this study, Noguerales and Ortego found genomic evidence supporting the hybrid origin of a grasshopper that is able to exploit a broader range of host plants than either of its putative parents.","lang":"eng"}],"publication_identifier":{"eissn":["1558-5646"],"issn":["0014-3820"]},"status":"public","publication_status":"published","file_date_updated":"2023-01-27T11:28:38Z","ddc":["570"],"month":"11","day":"01","citation":{"ieee":"S. Stankowski, “Digest: On the origin of a possible hybrid species,” <i>Evolution</i>, vol. 76, no. 11. Wiley, pp. 2784–2785, 2022.","apa":"Stankowski, S. (2022). Digest: On the origin of a possible hybrid species. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.14632\">https://doi.org/10.1111/evo.14632</a>","ama":"Stankowski S. Digest: On the origin of a possible hybrid species. <i>Evolution</i>. 2022;76(11):2784-2785. doi:<a href=\"https://doi.org/10.1111/evo.14632\">10.1111/evo.14632</a>","ista":"Stankowski S. 2022. Digest: On the origin of a possible hybrid species. Evolution. 76(11), 2784–2785.","short":"S. Stankowski, Evolution 76 (2022) 2784–2785.","chicago":"Stankowski, Sean. “Digest: On the Origin of a Possible Hybrid Species.” <i>Evolution</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/evo.14632\">https://doi.org/10.1111/evo.14632</a>.","mla":"Stankowski, Sean. “Digest: On the Origin of a Possible Hybrid Species.” <i>Evolution</i>, vol. 76, no. 11, Wiley, 2022, pp. 2784–85, doi:<a href=\"https://doi.org/10.1111/evo.14632\">10.1111/evo.14632</a>."},"oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"creator":"dernst","relation":"main_file","file_size":287282,"file_name":"2022_Evolution_Stankowski.pdf","date_updated":"2023-01-27T11:28:38Z","success":1,"content_type":"application/pdf","checksum":"4c0f05083b414ac0323a1b9ee1abc275","access_level":"open_access","date_created":"2023-01-27T11:28:38Z","file_id":"12425"}],"article_processing_charge":"Yes (via OA deal)","volume":76,"has_accepted_license":"1","oa":1,"keyword":["General Agricultural and Biological Sciences","Genetics","Ecology","Evolution","Behavior and Systematics"],"year":"2022","date_updated":"2023-08-04T09:35:48Z","publication":"Evolution","article_type":"original","page":"2784-2785","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"NiBa"}],"scopus_import":"1","date_created":"2023-01-16T09:50:48Z","external_id":{"isi":["000855751600001"]},"date_published":"2022-11-01T00:00:00Z","intvolume":"        76","publisher":"Wiley","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","isi":1},{"oa":1,"year":"2022","keyword":["Hematology","General Medicine"],"publication":"European Journal of Haematology","date_updated":"2023-08-04T09:36:21Z","article_type":"original","page":"566-575","department":[{"_id":"MaRo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2022-11-01T00:00:00Z","external_id":{"isi":["000849690500001"],"pmid":["36059200"]},"scopus_import":"1","date_created":"2023-01-16T09:50:58Z","intvolume":"       109","publisher":"Wiley","isi":1,"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","author":[{"first_name":"Marion","full_name":"Patxot, Marion","last_name":"Patxot"},{"first_name":"Miloš","last_name":"Stojanov","full_name":"Stojanov, Miloš"},{"last_name":"Ojavee","full_name":"Ojavee, Sven Erik","first_name":"Sven Erik"},{"last_name":"Gobert","full_name":"Gobert, Rosanna Pescini","first_name":"Rosanna Pescini"},{"first_name":"Zoltán","full_name":"Kutalik, Zoltán","last_name":"Kutalik"},{"last_name":"Gavillet","full_name":"Gavillet, Mathilde","first_name":"Mathilde"},{"full_name":"Baud, David","last_name":"Baud","first_name":"David"},{"orcid":"0000-0001-8982-8813","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","last_name":"Robinson"}],"title":"Haematological changes from conception to childbirth: An indicator of major pregnancy complications","_id":"12235","issue":"5","abstract":[{"lang":"eng","text":"Background: About 800 women die every day worldwide from pregnancy-related complications, including excessive blood loss, infections and high-blood pressure (World Health Organization, 2019). To improve screening for high-risk pregnancies, we set out to identify patterns of maternal hematological changes associated with future pregnancy complications.\r\n\r\nMethods: Using mixed effects models, we established changes in 14 complete blood count (CBC) parameters for 1710 healthy pregnancies and compared them to measurements from 98 pregnancy-induced hypertension, 106 gestational diabetes and 339 postpartum hemorrhage cases.\r\n\r\nResults: Results show interindividual variations, but good individual repeatability in CBC values during physiological pregnancies, allowing the identification of specific alterations in women with obstetric complications. For example, in women with uncomplicated pregnancies, haemoglobin count decreases of 0.12 g/L (95% CI −0.16, −0.09) significantly per gestation week (p value <.001). Interestingly, this decrease is three times more pronounced in women who will develop pregnancy-induced hypertension, with an additional decrease of 0.39 g/L (95% CI −0.51, −0.26). We also confirm that obstetric complications and white CBC predict the likelihood of giving birth earlier during pregnancy.\r\n\r\nConclusion: We provide a comprehensive description of the associations between haematological changes through pregnancy and three major obstetric complications to support strategies for prevention, early-diagnosis and maternal care."}],"doi":"10.1111/ejh.13844","publication_identifier":{"eissn":["1600-0609"],"issn":["0902-4441"]},"status":"public","publication_status":"published","acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria. We would like to thank the participants of the study and all the midwives and doctors involved for the computerized obstetrical data from the CHUV Maternity Hospital. Open access funding provided by Universite de Lausanne.","day":"01","citation":{"chicago":"Patxot, Marion, Miloš Stojanov, Sven Erik Ojavee, Rosanna Pescini Gobert, Zoltán Kutalik, Mathilde Gavillet, David Baud, and Matthew Richard Robinson. “Haematological Changes from Conception to Childbirth: An Indicator of Major Pregnancy Complications.” <i>European Journal of Haematology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/ejh.13844\">https://doi.org/10.1111/ejh.13844</a>.","mla":"Patxot, Marion, et al. “Haematological Changes from Conception to Childbirth: An Indicator of Major Pregnancy Complications.” <i>European Journal of Haematology</i>, vol. 109, no. 5, Wiley, 2022, pp. 566–75, doi:<a href=\"https://doi.org/10.1111/ejh.13844\">10.1111/ejh.13844</a>.","ieee":"M. Patxot <i>et al.</i>, “Haematological changes from conception to childbirth: An indicator of major pregnancy complications,” <i>European Journal of Haematology</i>, vol. 109, no. 5. Wiley, pp. 566–575, 2022.","apa":"Patxot, M., Stojanov, M., Ojavee, S. E., Gobert, R. P., Kutalik, Z., Gavillet, M., … Robinson, M. R. (2022). Haematological changes from conception to childbirth: An indicator of major pregnancy complications. <i>European Journal of Haematology</i>. Wiley. <a href=\"https://doi.org/10.1111/ejh.13844\">https://doi.org/10.1111/ejh.13844</a>","ista":"Patxot M, Stojanov M, Ojavee SE, Gobert RP, Kutalik Z, Gavillet M, Baud D, Robinson MR. 2022. Haematological changes from conception to childbirth: An indicator of major pregnancy complications. European Journal of Haematology. 109(5), 566–575.","ama":"Patxot M, Stojanov M, Ojavee SE, et al. Haematological changes from conception to childbirth: An indicator of major pregnancy complications. <i>European Journal of Haematology</i>. 2022;109(5):566-575. doi:<a href=\"https://doi.org/10.1111/ejh.13844\">10.1111/ejh.13844</a>","short":"M. Patxot, M. Stojanov, S.E. Ojavee, R.P. Gobert, Z. Kutalik, M. Gavillet, D. Baud, M.R. Robinson, European Journal of Haematology 109 (2022) 566–575."},"ddc":["570","610"],"pmid":1,"file_date_updated":"2023-01-27T11:42:43Z","month":"11","oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"date_created":"2023-01-27T11:42:43Z","file_id":"12426","relation":"main_file","creator":"dernst","file_size":1225073,"file_name":"2022_EuropJourHaematology_Patxot.pdf","checksum":"a676d732f67c2990197e34f96b219370","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-27T11:42:43Z","success":1}],"has_accepted_license":"1","volume":109,"article_processing_charge":"No"},{"article_processing_charge":"No","volume":14,"oa_version":"None","citation":{"ieee":"X. Wang <i>et al.</i>, “CoFeNiMnZnB as a high-entropy metal boride to boost the oxygen evolution reaction,” <i>ACS Applied Materials &#38; Interfaces</i>, vol. 14, no. 42. American Chemical Society, pp. 48212–48219, 2022.","apa":"Wang, X., Zuo, Y., Horta, S., He, R., Yang, L., Ostovari Moghaddam, A., … Cabot, A. (2022). CoFeNiMnZnB as a high-entropy metal boride to boost the oxygen evolution reaction. <i>ACS Applied Materials &#38; Interfaces</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsami.2c11627\">https://doi.org/10.1021/acsami.2c11627</a>","ama":"Wang X, Zuo Y, Horta S, et al. CoFeNiMnZnB as a high-entropy metal boride to boost the oxygen evolution reaction. <i>ACS Applied Materials &#38; Interfaces</i>. 2022;14(42):48212-48219. doi:<a href=\"https://doi.org/10.1021/acsami.2c11627\">10.1021/acsami.2c11627</a>","ista":"Wang X, Zuo Y, Horta S, He R, Yang L, Ostovari Moghaddam A, Ibáñez M, Qi X, Cabot A. 2022. CoFeNiMnZnB as a high-entropy metal boride to boost the oxygen evolution reaction. ACS Applied Materials &#38; Interfaces. 14(42), 48212–48219.","short":"X. Wang, Y. Zuo, S. Horta, R. He, L. Yang, A. Ostovari Moghaddam, M. Ibáñez, X. Qi, A. Cabot, ACS Applied Materials &#38; Interfaces 14 (2022) 48212–48219.","mla":"Wang, Xiang, et al. “CoFeNiMnZnB as a High-Entropy Metal Boride to Boost the Oxygen Evolution Reaction.” <i>ACS Applied Materials &#38; Interfaces</i>, vol. 14, no. 42, American Chemical Society, 2022, pp. 48212–19, doi:<a href=\"https://doi.org/10.1021/acsami.2c11627\">10.1021/acsami.2c11627</a>.","chicago":"Wang, Xiang, Yong Zuo, Sharona Horta, Ren He, Linlin Yang, Ahmad Ostovari Moghaddam, Maria Ibáñez, Xueqiang Qi, and Andreu Cabot. “CoFeNiMnZnB as a High-Entropy Metal Boride to Boost the Oxygen Evolution Reaction.” <i>ACS Applied Materials &#38; Interfaces</i>. American Chemical Society, 2022. <a href=\"https://doi.org/10.1021/acsami.2c11627\">https://doi.org/10.1021/acsami.2c11627</a>."},"day":"14","pmid":1,"month":"10","status":"public","publication_status":"published","acknowledgement":"This work was supported by the Spanish MCIN project COMBENERGY (PID2019-105490RB-C32). X.W. and L.Y. thank the China Scholarship Council (CSC) for the scholarship support.","publication_identifier":{"issn":["1944-8244"],"eissn":["1944-8252"]},"abstract":[{"lang":"eng","text":"High-entropy materials offer numerous advantages as catalysts, including a flexible composition to tune the catalytic activity and selectivity and a large variety of adsorption/reaction sites for multistep or multiple reactions. Herein, we report on the synthesis, properties, and electrocatalytic performance of an amorphous high-entropy boride based on abundant transition metals, CoFeNiMnZnB. This metal boride provides excellent performance toward the oxygen evolution reaction (OER), including a low overpotential of 261 mV at 10 mA cm–2, a reduced Tafel slope of 56.8 mV dec–1, and very high stability. The outstanding OER performance of CoFeNiMnZnB is attributed to the synergistic interactions between the different metals, the leaching of Zn ions, the generation of oxygen vacancies, and the in situ formation of an amorphous oxyhydroxide at the CoFeNiMnZnB surface during the OER."}],"issue":"42","doi":"10.1021/acsami.2c11627","title":"CoFeNiMnZnB as a high-entropy metal boride to boost the oxygen evolution reaction","author":[{"first_name":"Xiang","last_name":"Wang","full_name":"Wang, Xiang"},{"full_name":"Zuo, Yong","last_name":"Zuo","first_name":"Yong"},{"full_name":"Horta, Sharona","last_name":"Horta","id":"03a7e858-01b1-11ec-8b71-99ae6c4a05bc","first_name":"Sharona"},{"last_name":"He","full_name":"He, Ren","first_name":"Ren"},{"first_name":"Linlin","last_name":"Yang","full_name":"Yang, Linlin"},{"last_name":"Ostovari Moghaddam","full_name":"Ostovari Moghaddam, Ahmad","first_name":"Ahmad"},{"first_name":"Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","last_name":"Ibáñez","full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843"},{"full_name":"Qi, Xueqiang","last_name":"Qi","first_name":"Xueqiang"},{"first_name":"Andreu","last_name":"Cabot","full_name":"Cabot, Andreu"}],"_id":"12236","isi":1,"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"publisher":"American Chemical Society","intvolume":"        14","external_id":{"pmid":["36239982"],"isi":["000873782700001"]},"date_published":"2022-10-14T00:00:00Z","date_created":"2023-01-16T09:51:10Z","scopus_import":"1","department":[{"_id":"MaIb"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"48212-48219","article_type":"original","publication":"ACS Applied Materials & Interfaces","date_updated":"2023-10-04T08:28:14Z","year":"2022","keyword":["General Materials Science"]},{"oa":1,"keyword":["Materials Chemistry","General Chemical Engineering","General Chemistry"],"year":"2022","date_updated":"2023-08-04T09:38:26Z","publication":"Chemistry of Materials","article_type":"original","page":"8471-8489","related_material":{"record":[{"id":"12885","relation":"dissertation_contains","status":"public"}]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"MaIb"}],"scopus_import":"1","date_created":"2023-01-16T09:51:26Z","external_id":{"pmid":["36248227"],"isi":["000917837600001"]},"date_published":"2022-09-20T00:00:00Z","intvolume":"        34","publisher":"American Chemical Society","language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","isi":1,"_id":"12237","author":[{"full_name":"Fiedler, Christine","last_name":"Fiedler","id":"bd3fceba-dc74-11ea-a0a7-c17f71817366","first_name":"Christine"},{"first_name":"Tobias","id":"8BD9DE16-AB3C-11E9-9C8C-2A03E6697425","last_name":"Kleinhanns","full_name":"Kleinhanns, Tobias"},{"last_name":"Garcia","full_name":"Garcia, Maria","first_name":"Maria","id":"6e5c50b8-97dc-11ed-be98-b0a74c84cae0"},{"last_name":"Lee","full_name":"Lee, Seungho","first_name":"Seungho","id":"BB243B88-D767-11E9-B658-BC13E6697425","orcid":"0000-0002-6962-8598"},{"first_name":"Mariano","id":"45D7531A-F248-11E8-B48F-1D18A9856A87","last_name":"Calcabrini","full_name":"Calcabrini, Mariano"},{"full_name":"Ibáñez, Maria","last_name":"Ibáñez","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","orcid":"0000-0001-5013-2843"}],"title":"Solution-processed inorganic thermoelectric materials: Opportunities and challenges","doi":"10.1021/acs.chemmater.2c01967","issue":"19","abstract":[{"lang":"eng","text":"Thermoelectric technology requires synthesizing complex materials where not only the crystal structure but also other structural features such as defects, grain size and orientation, and interfaces must be controlled. To date, conventional solid-state techniques are unable to provide this level of control. Herein, we present a synthetic approach in which dense inorganic thermoelectric materials are produced by the consolidation of well-defined nanoparticle powders. The idea is that controlling the characteristics of the powder allows the chemical transformations that take place during consolidation to be guided, ultimately yielding inorganic solids with targeted features. Different from conventional methods, syntheses in solution can produce particles with unprecedented control over their size, shape, crystal structure, composition, and surface chemistry. However, to date, most works have focused only on the low-cost benefits of this strategy. In this perspective, we first cover the opportunities that solution processing of the powder offers, emphasizing the potential structural features that can be controlled by precisely engineering the inorganic core of the particle, the surface, and the organization of the particles before consolidation. We then discuss the challenges of this synthetic approach and more practical matters related to solution processing. Finally, we suggest some good practices for adequate knowledge transfer and improving reproducibility among different laboratories."}],"project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program"}],"publication_identifier":{"eissn":["1520-5002"],"issn":["0897-4756"]},"ec_funded":1,"acknowledgement":"This work was financially supported by ISTA and the Werner Siemens Foundation. M.C. has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement no. 665385.","status":"public","publication_status":"published","pmid":1,"month":"09","file_date_updated":"2023-01-30T07:35:09Z","ddc":["540"],"day":"20","citation":{"ama":"Fiedler C, Kleinhanns T, Garcia M, Lee S, Calcabrini M, Ibáñez M. Solution-processed inorganic thermoelectric materials: Opportunities and challenges. <i>Chemistry of Materials</i>. 2022;34(19):8471-8489. doi:<a href=\"https://doi.org/10.1021/acs.chemmater.2c01967\">10.1021/acs.chemmater.2c01967</a>","ista":"Fiedler C, Kleinhanns T, Garcia M, Lee S, Calcabrini M, Ibáñez M. 2022. Solution-processed inorganic thermoelectric materials: Opportunities and challenges. Chemistry of Materials. 34(19), 8471–8489.","short":"C. Fiedler, T. Kleinhanns, M. Garcia, S. Lee, M. Calcabrini, M. Ibáñez, Chemistry of Materials 34 (2022) 8471–8489.","apa":"Fiedler, C., Kleinhanns, T., Garcia, M., Lee, S., Calcabrini, M., &#38; Ibáñez, M. (2022). Solution-processed inorganic thermoelectric materials: Opportunities and challenges. <i>Chemistry of Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.chemmater.2c01967\">https://doi.org/10.1021/acs.chemmater.2c01967</a>","ieee":"C. Fiedler, T. Kleinhanns, M. Garcia, S. Lee, M. Calcabrini, and M. Ibáñez, “Solution-processed inorganic thermoelectric materials: Opportunities and challenges,” <i>Chemistry of Materials</i>, vol. 34, no. 19. American Chemical Society, pp. 8471–8489, 2022.","mla":"Fiedler, Christine, et al. “Solution-Processed Inorganic Thermoelectric Materials: Opportunities and Challenges.” <i>Chemistry of Materials</i>, vol. 34, no. 19, American Chemical Society, 2022, pp. 8471–89, doi:<a href=\"https://doi.org/10.1021/acs.chemmater.2c01967\">10.1021/acs.chemmater.2c01967</a>.","chicago":"Fiedler, Christine, Tobias Kleinhanns, Maria Garcia, Seungho Lee, Mariano Calcabrini, and Maria Ibáñez. “Solution-Processed Inorganic Thermoelectric Materials: Opportunities and Challenges.” <i>Chemistry of Materials</i>. American Chemical Society, 2022. <a href=\"https://doi.org/10.1021/acs.chemmater.2c01967\">https://doi.org/10.1021/acs.chemmater.2c01967</a>."},"oa_version":"Published Version","file":[{"date_updated":"2023-01-30T07:35:09Z","success":1,"checksum":"f7143e44ab510519d1949099c3558532","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_size":10923495,"creator":"dernst","file_name":"2022_ChemistryMaterials_Fiedler.pdf","date_created":"2023-01-30T07:35:09Z","file_id":"12434"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":34,"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1"},{"volume":57,"article_processing_charge":"No","day":"01","citation":{"mla":"Hino, Naoya, et al. “A Feedback Loop between Lamellipodial Extension and HGF-ERK Signaling Specifies Leader Cells during Collective Cell Migration.” <i>Developmental Cell</i>, vol. 57, no. 19, Elsevier, 2022, p. 2290–2304.e7, doi:<a href=\"https://doi.org/10.1016/j.devcel.2022.09.003\">10.1016/j.devcel.2022.09.003</a>.","chicago":"Hino, Naoya, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Shinya Tsukiji, et al. “A Feedback Loop between Lamellipodial Extension and HGF-ERK Signaling Specifies Leader Cells during Collective Cell Migration.” <i>Developmental Cell</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.devcel.2022.09.003\">https://doi.org/10.1016/j.devcel.2022.09.003</a>.","short":"N. Hino, K. Matsuda, Y. Jikko, G. Maryu, K. Sakai, R. Imamura, S. Tsukiji, K. Aoki, K. Terai, T. Hirashima, X. Trepat, M. Matsuda, Developmental Cell 57 (2022) 2290–2304.e7.","ama":"Hino N, Matsuda K, Jikko Y, et al. A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. <i>Developmental Cell</i>. 2022;57(19):2290-2304.e7. doi:<a href=\"https://doi.org/10.1016/j.devcel.2022.09.003\">10.1016/j.devcel.2022.09.003</a>","ista":"Hino N, Matsuda K, Jikko Y, Maryu G, Sakai K, Imamura R, Tsukiji S, Aoki K, Terai K, Hirashima T, Trepat X, Matsuda M. 2022. A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. Developmental Cell. 57(19), 2290–2304.e7.","apa":"Hino, N., Matsuda, K., Jikko, Y., Maryu, G., Sakai, K., Imamura, R., … Matsuda, M. (2022). A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2022.09.003\">https://doi.org/10.1016/j.devcel.2022.09.003</a>","ieee":"N. Hino <i>et al.</i>, “A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration,” <i>Developmental Cell</i>, vol. 57, no. 19. Elsevier, p. 2290–2304.e7, 2022."},"month":"10","pmid":1,"oa_version":"None","publication_identifier":{"issn":["1534-5807"]},"status":"public","acknowledgement":"We thank the members of the Matsuda Laboratory for their helpful discussion and encouragement, and we thank K. Hirano and K. Takakura for their technical assistance. This work was supported by the Kyoto University Live Imaging Center. Financial support was provided in the form of JSPS KAKENHI grants (nos. 17J02107 and 20K22653 to N.H., and 20H05898 and 19H00993 to M.M.), a JST CREST grant (no. JPMJCR1654 to M.M.), a Moonshot R&D grant (no. JPMJPS2022-11 to M.M.), Generalitat de Catalunya and the CERCA Programme (no. SGR-2017-01602 to X.T.), MICCINN/FEDER (no. PGC2018-099645-B-I00 to X.T.), and European Research Council (no. Adv-883739 to X.T.). IBEC is a recipient of a Severo Ochoa Award of Excellence from the MINECO. This work was partly supported by an Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University.","publication_status":"published","author":[{"full_name":"Hino, Naoya","last_name":"Hino","id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","first_name":"Naoya"},{"first_name":"Kimiya","last_name":"Matsuda","full_name":"Matsuda, Kimiya"},{"last_name":"Jikko","full_name":"Jikko, Yuya","first_name":"Yuya"},{"full_name":"Maryu, Gembu","last_name":"Maryu","first_name":"Gembu"},{"last_name":"Sakai","full_name":"Sakai, Katsuya","first_name":"Katsuya"},{"first_name":"Ryu","last_name":"Imamura","full_name":"Imamura, Ryu"},{"last_name":"Tsukiji","full_name":"Tsukiji, Shinya","first_name":"Shinya"},{"full_name":"Aoki, Kazuhiro","last_name":"Aoki","first_name":"Kazuhiro"},{"first_name":"Kenta","full_name":"Terai, Kenta","last_name":"Terai"},{"first_name":"Tsuyoshi","full_name":"Hirashima, Tsuyoshi","last_name":"Hirashima"},{"full_name":"Trepat, Xavier","last_name":"Trepat","first_name":"Xavier"},{"first_name":"Michiyuki","last_name":"Matsuda","full_name":"Matsuda, Michiyuki"}],"title":"A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration","_id":"12238","issue":"19","abstract":[{"text":"Upon the initiation of collective cell migration, the cells at the free edge are specified as leader cells; however, the mechanism underlying the leader cell specification remains elusive. Here, we show that lamellipodial extension after the release from mechanical confinement causes sustained extracellular signal-regulated kinase (ERK) activation and underlies the leader cell specification. Live-imaging of Madin-Darby canine kidney (MDCK) cells and mouse epidermis through the use of Förster resonance energy transfer (FRET)-based biosensors showed that leader cells exhibit sustained ERK activation in a hepatocyte growth factor (HGF)-dependent manner. Meanwhile, follower cells exhibit oscillatory ERK activation waves in an epidermal growth factor (EGF) signaling-dependent manner. Lamellipodial extension at the free edge increases the cellular sensitivity to HGF. The HGF-dependent ERK activation, in turn, promotes lamellipodial extension, thereby forming a positive feedback loop between cell extension and ERK activation and specifying the cells at the free edge as the leader cells. Our findings show that the integration of physical and biochemical cues underlies the leader cell specification during collective cell migration.","lang":"eng"}],"doi":"10.1016/j.devcel.2022.09.003","intvolume":"        57","publisher":"Elsevier","isi":1,"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","department":[{"_id":"CaHe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2022-10-01T00:00:00Z","external_id":{"pmid":["36174555"],"isi":["000898428700006"]},"scopus_import":"1","date_created":"2023-01-16T09:51:39Z","publication":"Developmental Cell","date_updated":"2023-08-04T09:38:53Z","article_type":"original","page":"2290-2304.e7","year":"2022","keyword":["Developmental Biology","Cell Biology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology"]}]