---
_id: '9917'
abstract:
- lang: eng
text: Adaptive divergence and speciation may happen despite opposition by gene flow.
Identifying the genomic basis underlying divergence with gene flow is a major
task in evolutionary genomics. Most approaches (e.g., outlier scans) focus on
genomic regions of high differentiation. However, not all genomic architectures
potentially underlying divergence are expected to show extreme differentiation.
Here, we develop an approach that combines hybrid zone analysis (i.e., focuses
on spatial patterns of allele frequency change) with system-specific simulations
to identify loci inconsistent with neutral evolution. We apply this to a genome-wide
SNP set from an ideally suited study organism, the intertidal snail Littorina
saxatilis, which shows primary divergence between ecotypes associated with different
shore habitats. We detect many SNPs with clinal patterns, most of which are consistent
with neutrality. Among non-neutral SNPs, most are located within three large putative
inversions differentiating ecotypes. Many non-neutral SNPs show relatively low
levels of differentiation. We discuss potential reasons for this pattern, including
loose linkage to selected variants, polygenic adaptation and a component of balancing
selection within populations (which may be expected for inversions). Our work
is in line with theory predicting a role for inversions in divergence, and emphasizes
that genomic regions contributing to divergence may not always be accessible with
methods purely based on allele frequency differences. These conclusions call for
approaches that take spatial patterns of allele frequency change into account
in other systems.
acknowledgement: We are very grateful to people who helped with fieldwork, snail processing,
and DNA extractions, particularly Laura Brettell, Mårten Duvetorp, Juan Galindo,
Anne-Lise Liabot and Irena Senčić. We would also like to thank Magnus Alm Rosenblad
and Mats Töpel for their contribution to assembling the Littorina saxatilis genome,
Carl André, Pasi Rastas, and Romain Villoutreix for discussion, and two anonymous
reviewers for their helpful comments on the manuscript. We are grateful to RapidGenomics
for library preparation and sequencing. We thank the Natural Environment Research
Council, the European Research Council and the Swedish Research Councils VR and
Formas (Linnaeus grant to the Centre for Marine Evolutionary Biology and Tage Erlander
Guest Professorship) for funding. P.C. was funded by the University of Sheffield
Vice-chancellor's India scholarship. R.F. is funded by the European Union's Horizon
2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement
no. 706376. M. Raf. was supported by the Adlerbert Research Foundation.
article_processing_charge: Yes
article_type: letter_note
author:
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Marina
full_name: Rafajlović, Marina
last_name: Rafajlović
- first_name: Pragya
full_name: Chaube, Pragya
last_name: Chaube
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Tomas
full_name: Larsson, Tomas
last_name: Larsson
- first_name: Marina
full_name: Panova, Marina
last_name: Panova
- first_name: Mark
full_name: Ravinet, Mark
last_name: Ravinet
- first_name: Anders
full_name: Blomberg, Anders
last_name: Blomberg
- first_name: Bernhard
full_name: Mehlig, Bernhard
last_name: Mehlig
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Westram AM, Rafajlović M, Chaube P, et al. Clines on the seashore: The genomic
architecture underlying rapid divergence in the face of gene flow. Evolution
Letters. 2018;2(4):297-309. doi:10.1002/evl3.74'
apa: 'Westram, A. M., Rafajlović, M., Chaube, P., Faria, R., Larsson, T., Panova,
M., … Butlin, R. (2018). Clines on the seashore: The genomic architecture underlying
rapid divergence in the face of gene flow. Evolution Letters. Wiley. https://doi.org/10.1002/evl3.74'
chicago: 'Westram, Anja M, Marina Rafajlović, Pragya Chaube, Rui Faria, Tomas Larsson,
Marina Panova, Mark Ravinet, et al. “Clines on the Seashore: The Genomic Architecture
Underlying Rapid Divergence in the Face of Gene Flow.” Evolution Letters.
Wiley, 2018. https://doi.org/10.1002/evl3.74.'
ieee: 'A. M. Westram et al., “Clines on the seashore: The genomic architecture
underlying rapid divergence in the face of gene flow,” Evolution Letters,
vol. 2, no. 4. Wiley, pp. 297–309, 2018.'
ista: 'Westram AM, Rafajlović M, Chaube P, Faria R, Larsson T, Panova M, Ravinet
M, Blomberg A, Mehlig B, Johannesson K, Butlin R. 2018. Clines on the seashore:
The genomic architecture underlying rapid divergence in the face of gene flow.
Evolution Letters. 2(4), 297–309.'
mla: 'Westram, Anja M., et al. “Clines on the Seashore: The Genomic Architecture
Underlying Rapid Divergence in the Face of Gene Flow.” Evolution Letters,
vol. 2, no. 4, Wiley, 2018, pp. 297–309, doi:10.1002/evl3.74.'
short: A.M. Westram, M. Rafajlović, P. Chaube, R. Faria, T. Larsson, M. Panova,
M. Ravinet, A. Blomberg, B. Mehlig, K. Johannesson, R. Butlin, Evolution Letters
2 (2018) 297–309.
date_created: 2021-08-16T07:45:38Z
date_published: 2018-08-20T00:00:00Z
date_updated: 2023-09-19T15:08:25Z
day: '20'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1002/evl3.74
external_id:
isi:
- '000446774400004'
pmid:
- '30283683'
file:
- access_level: open_access
checksum: 8524e72507d521416be3f8ccfcd5e3f5
content_type: application/pdf
creator: asandaue
date_created: 2021-08-16T07:48:03Z
date_updated: 2021-08-16T07:48:03Z
file_id: '9918'
file_name: 2018_EvolutionLetters_Westram.pdf
file_size: 764299
relation: main_file
success: 1
file_date_updated: 2021-08-16T07:48:03Z
has_accepted_license: '1'
intvolume: ' 2'
isi: 1
issue: '4'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 297-309
pmid: 1
publication: Evolution Letters
publication_identifier:
eissn:
- 2056-3744
issn:
- 2056-3744
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '9930'
relation: research_data
status: public
status: public
title: 'Clines on the seashore: The genomic architecture underlying rapid divergence
in the face of gene flow'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2
year: '2018'
...
---
_id: '9929'
abstract:
- lang: eng
text: 'The evolution of assortative mating is a key part of the speciation process.
Stronger assortment, or greater divergence in mating traits, between species pairs
with overlapping ranges is commonly observed, but possible causes of this pattern
of reproductive character displacement are difficult to distinguish. We use a
multidisciplinary approach to provide a rare example where it is possible to distinguish
among hypotheses concerning the evolution of reproductive character displacement.
We build on an earlier comparative analysis that illustrated a strong pattern
of greater divergence in penis form between pairs of sister species with overlapping
ranges than between allopatric sister-species pairs, in a large clade of marine
gastropods (Littorinidae). We investigate both assortative mating and divergence
in male genitalia in one of the sister-species pairs, discriminating among three
contrasting processes each of which can generate a pattern of reproductive character
displacement: reinforcement, reproductive interference and the Templeton effect.
We demonstrate reproductive character displacement in assortative mating, but
not in genital form between this pair of sister species and use demographic models
to distinguish among the different processes. Our results support a model with
no gene flow since secondary contact and thus favour reproductive interference
as the cause of reproductive character displacement for mate choice, rather than
reinforcement. High gene flow within species argues against the Templeton effect.
Secondary contact appears to have had little impact on genital divergence.'
article_processing_charge: No
author:
- first_name: Johan
full_name: Hollander, Johan
last_name: Hollander
- first_name: Mauricio
full_name: Montaño-Rendón, Mauricio
last_name: Montaño-Rendón
- first_name: Giuseppe
full_name: Bianco, Giuseppe
last_name: Bianco
- first_name: Xi
full_name: Yang, Xi
last_name: Yang
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Ludovic
full_name: Duvaux, Ludovic
last_name: Duvaux
- first_name: David G.
full_name: Reid, David G.
last_name: Reid
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: 'Hollander J, Montaño-Rendón M, Bianco G, et al. Data from: Are assortative
mating and genital divergence driven by reinforcement? 2018. doi:10.5061/dryad.51sd2p5'
apa: 'Hollander, J., Montaño-Rendón, M., Bianco, G., Yang, X., Westram, A. M., Duvaux,
L., … Butlin, R. K. (2018). Data from: Are assortative mating and genital divergence
driven by reinforcement? Dryad. https://doi.org/10.5061/dryad.51sd2p5'
chicago: 'Hollander, Johan, Mauricio Montaño-Rendón, Giuseppe Bianco, Xi Yang, Anja
M Westram, Ludovic Duvaux, David G. Reid, and Roger K. Butlin. “Data from: Are
Assortative Mating and Genital Divergence Driven by Reinforcement?” Dryad, 2018.
https://doi.org/10.5061/dryad.51sd2p5.'
ieee: 'J. Hollander et al., “Data from: Are assortative mating and genital
divergence driven by reinforcement?” Dryad, 2018.'
ista: 'Hollander J, Montaño-Rendón M, Bianco G, Yang X, Westram AM, Duvaux L, Reid
DG, Butlin RK. 2018. Data from: Are assortative mating and genital divergence
driven by reinforcement?, Dryad, 10.5061/dryad.51sd2p5.'
mla: 'Hollander, Johan, et al. Data from: Are Assortative Mating and Genital
Divergence Driven by Reinforcement? Dryad, 2018, doi:10.5061/dryad.51sd2p5.'
short: J. Hollander, M. Montaño-Rendón, G. Bianco, X. Yang, A.M. Westram, L. Duvaux,
D.G. Reid, R.K. Butlin, (2018).
date_created: 2021-08-17T08:51:06Z
date_published: 2018-10-17T00:00:00Z
date_updated: 2023-09-19T15:08:53Z
day: '17'
department:
- _id: BeVi
doi: 10.5061/dryad.51sd2p5
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.51sd2p5
month: '10'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '9915'
relation: used_in_publication
status: public
status: public
title: 'Data from: Are assortative mating and genital divergence driven by reinforcement?'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2018'
...
---
_id: '9930'
abstract:
- lang: eng
text: Adaptive divergence and speciation may happen despite opposition by gene flow.
Identifying the genomic basis underlying divergence with gene flow is a major
task in evolutionary genomics. Most approaches (e.g. outlier scans) focus on genomic
regions of high differentiation. However, not all genomic architectures potentially
underlying divergence are expected to show extreme differentiation. Here, we develop
an approach that combines hybrid zone analysis (i.e. focuses on spatial patterns
of allele frequency change) with system-specific simulations to identify loci
inconsistent with neutral evolution. We apply this to a genome-wide SNP set from
an ideally-suited study organism, the intertidal snail Littorina saxatilis, which
shows primary divergence between ecotypes associated with different shore habitats.
We detect many SNPs with clinal patterns, most of which are consistent with neutrality.
Among non-neutral SNPs, most are located within three large putative inversions
differentiating ecotypes. Many non-neutral SNPs show relatively low levels of
differentiation. We discuss potential reasons for this pattern, including loose
linkage to selected variants, polygenic adaptation and a component of balancing
selection within populations (which may be expected for inversions). Our work
is in line with theory predicting a role for inversions in divergence, and emphasises
that genomic regions contributing to divergence may not always be accessible with
methods purely based on allele frequency differences. These conclusions call for
approaches that take spatial patterns of allele frequency change into account
in other systems.
article_processing_charge: No
author:
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Marina
full_name: Rafajlović, Marina
last_name: Rafajlović
- first_name: Pragya
full_name: Chaube, Pragya
last_name: Chaube
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Tomas
full_name: Larsson, Tomas
last_name: Larsson
- first_name: Marina
full_name: Panova, Marina
last_name: Panova
- first_name: Mark
full_name: Ravinet, Mark
last_name: Ravinet
- first_name: Anders
full_name: Blomberg, Anders
last_name: Blomberg
- first_name: Bernhard
full_name: Mehlig, Bernhard
last_name: Mehlig
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Westram AM, Rafajlović M, Chaube P, et al. Data from: Clines on the seashore:
the genomic architecture underlying rapid divergence in the face of gene flow.
2018. doi:10.5061/dryad.bp25b65'
apa: 'Westram, A. M., Rafajlović, M., Chaube, P., Faria, R., Larsson, T., Panova,
M., … Butlin, R. (2018). Data from: Clines on the seashore: the genomic architecture
underlying rapid divergence in the face of gene flow. Dryad. https://doi.org/10.5061/dryad.bp25b65'
chicago: 'Westram, Anja M, Marina Rafajlović, Pragya Chaube, Rui Faria, Tomas Larsson,
Marina Panova, Mark Ravinet, et al. “Data from: Clines on the Seashore: The Genomic
Architecture Underlying Rapid Divergence in the Face of Gene Flow.” Dryad, 2018.
https://doi.org/10.5061/dryad.bp25b65.'
ieee: 'A. M. Westram et al., “Data from: Clines on the seashore: the genomic
architecture underlying rapid divergence in the face of gene flow.” Dryad, 2018.'
ista: 'Westram AM, Rafajlović M, Chaube P, Faria R, Larsson T, Panova M, Ravinet
M, Blomberg A, Mehlig B, Johannesson K, Butlin R. 2018. Data from: Clines on the
seashore: the genomic architecture underlying rapid divergence in the face of
gene flow, Dryad, 10.5061/dryad.bp25b65.'
mla: 'Westram, Anja M., et al. Data from: Clines on the Seashore: The Genomic
Architecture Underlying Rapid Divergence in the Face of Gene Flow. Dryad,
2018, doi:10.5061/dryad.bp25b65.'
short: A.M. Westram, M. Rafajlović, P. Chaube, R. Faria, T. Larsson, M. Panova,
M. Ravinet, A. Blomberg, B. Mehlig, K. Johannesson, R. Butlin, (2018).
date_created: 2021-08-17T08:58:47Z
date_published: 2018-07-23T00:00:00Z
date_updated: 2023-09-19T15:08:24Z
day: '23'
department:
- _id: BeVi
doi: 10.5061/dryad.bp25b65
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.bp25b65
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '9917'
relation: used_in_publication
status: public
status: public
title: 'Data from: Clines on the seashore: the genomic architecture underlying rapid
divergence in the face of gene flow'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2018'
...
---
_id: '10864'
abstract:
- lang: eng
text: We prove that every congruence distributive variety has directed Jónsson terms,
and every congruence modular variety has directed Gumm terms. The directed terms
we construct witness every case of absorption witnessed by the original Jónsson
or Gumm terms. This result is equivalent to a pair of claims about absorption
for admissible preorders in congruence distributive and congruence modular varieties,
respectively. For finite algebras, these absorption theorems have already seen
significant applications, but until now, it was not clear if the theorems hold
for general algebras as well. Our method also yields a novel proof of a result
by P. Lipparini about the existence of a chain of terms (which we call Pixley
terms) in varieties that are at the same time congruence distributive and k-permutable
for some k.
acknowledgement: The second author was supported by National Science Center grant
DEC-2011-/01/B/ST6/01006.
article_processing_charge: No
arxiv: 1
author:
- first_name: Alexandr
full_name: Kazda, Alexandr
id: 3B32BAA8-F248-11E8-B48F-1D18A9856A87
last_name: Kazda
- first_name: Marcin
full_name: Kozik, Marcin
last_name: Kozik
- first_name: Ralph
full_name: McKenzie, Ralph
last_name: McKenzie
- first_name: Matthew
full_name: Moore, Matthew
last_name: Moore
citation:
ama: 'Kazda A, Kozik M, McKenzie R, Moore M. Absorption and directed Jónsson terms.
In: Czelakowski J, ed. Don Pigozzi on Abstract Algebraic Logic, Universal Algebra,
and Computer Science. Vol 16. OCTR. Cham: Springer Nature; 2018:203-220. doi:10.1007/978-3-319-74772-9_7'
apa: 'Kazda, A., Kozik, M., McKenzie, R., & Moore, M. (2018). Absorption and
directed Jónsson terms. In J. Czelakowski (Ed.), Don Pigozzi on Abstract Algebraic
Logic, Universal Algebra, and Computer Science (Vol. 16, pp. 203–220). Cham:
Springer Nature. https://doi.org/10.1007/978-3-319-74772-9_7'
chicago: 'Kazda, Alexandr, Marcin Kozik, Ralph McKenzie, and Matthew Moore. “Absorption
and Directed Jónsson Terms.” In Don Pigozzi on Abstract Algebraic Logic, Universal
Algebra, and Computer Science, edited by J Czelakowski, 16:203–20. OCTR. Cham:
Springer Nature, 2018. https://doi.org/10.1007/978-3-319-74772-9_7.'
ieee: 'A. Kazda, M. Kozik, R. McKenzie, and M. Moore, “Absorption and directed Jónsson
terms,” in Don Pigozzi on Abstract Algebraic Logic, Universal Algebra, and
Computer Science, vol. 16, J. Czelakowski, Ed. Cham: Springer Nature, 2018,
pp. 203–220.'
ista: 'Kazda A, Kozik M, McKenzie R, Moore M. 2018.Absorption and directed Jónsson
terms. In: Don Pigozzi on Abstract Algebraic Logic, Universal Algebra, and Computer
Science. vol. 16, 203–220.'
mla: Kazda, Alexandr, et al. “Absorption and Directed Jónsson Terms.” Don Pigozzi
on Abstract Algebraic Logic, Universal Algebra, and Computer Science, edited
by J Czelakowski, vol. 16, Springer Nature, 2018, pp. 203–20, doi:10.1007/978-3-319-74772-9_7.
short: A. Kazda, M. Kozik, R. McKenzie, M. Moore, in:, J. Czelakowski (Ed.), Don
Pigozzi on Abstract Algebraic Logic, Universal Algebra, and Computer Science,
Springer Nature, Cham, 2018, pp. 203–220.
date_created: 2022-03-18T10:30:32Z
date_published: 2018-03-21T00:00:00Z
date_updated: 2023-09-05T15:37:18Z
day: '21'
department:
- _id: VlKo
doi: 10.1007/978-3-319-74772-9_7
editor:
- first_name: J
full_name: Czelakowski, J
last_name: Czelakowski
external_id:
arxiv:
- '1502.01072'
intvolume: ' 16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1502.01072
month: '03'
oa: 1
oa_version: Preprint
page: 203-220
place: Cham
publication: Don Pigozzi on Abstract Algebraic Logic, Universal Algebra, and Computer
Science
publication_identifier:
eisbn:
- '9783319747729'
eissn:
- 2211-2766
isbn:
- '9783319747712'
issn:
- 2211-2758
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: OCTR
status: public
title: Absorption and directed Jónsson terms
type: book_chapter
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 16
year: '2018'
...
---
_id: '10880'
abstract:
- lang: eng
text: Acquisition of evolutionary novelties is a fundamental process for adapting
to the external environment and invading new niches and results in the diversification
of life, which we can see in the world today. How such novel phenotypic traits
are acquired in the course of evolution and are built up in developing embryos
has been a central question in biology. Whole-genome duplication (WGD) is a process
of genome doubling that supplies raw genetic materials and increases genome complexity.
Recently, it has been gradually revealed that WGD and subsequent fate changes
of duplicated genes can facilitate phenotypic evolution. Here, we review the current
understanding of the relationship between WGD and the acquisition of evolutionary
novelties. We show some examples of this link and discuss how WGD and subsequent
duplicated genes can facilitate phenotypic evolution as well as when such genomic
doubling can be advantageous for adaptation.
acknowledgement: This work was supported by JSPS overseas research fellowships (Y.M.)
and SENSHIN Medical Research Foundation (K.K.T.).
article_processing_charge: No
article_type: original
author:
- first_name: Moriyama
full_name: Yuuta, Moriyama
id: 4968E7C8-F248-11E8-B48F-1D18A9856A87
last_name: Yuuta
orcid: 0000-0002-2853-8051
- first_name: Kazuko
full_name: Koshiba-Takeuchi, Kazuko
last_name: Koshiba-Takeuchi
citation:
ama: Yuuta M, Koshiba-Takeuchi K. Significance of whole-genome duplications on the
emergence of evolutionary novelties. Briefings in Functional Genomics.
2018;17(5):329-338. doi:10.1093/bfgp/ely007
apa: Yuuta, M., & Koshiba-Takeuchi, K. (2018). Significance of whole-genome
duplications on the emergence of evolutionary novelties. Briefings in Functional
Genomics. Oxford University Press. https://doi.org/10.1093/bfgp/ely007
chicago: Yuuta, Moriyama, and Kazuko Koshiba-Takeuchi. “Significance of Whole-Genome
Duplications on the Emergence of Evolutionary Novelties.” Briefings in Functional
Genomics. Oxford University Press, 2018. https://doi.org/10.1093/bfgp/ely007.
ieee: M. Yuuta and K. Koshiba-Takeuchi, “Significance of whole-genome duplications
on the emergence of evolutionary novelties,” Briefings in Functional Genomics,
vol. 17, no. 5. Oxford University Press, pp. 329–338, 2018.
ista: Yuuta M, Koshiba-Takeuchi K. 2018. Significance of whole-genome duplications
on the emergence of evolutionary novelties. Briefings in Functional Genomics.
17(5), 329–338.
mla: Yuuta, Moriyama, and Kazuko Koshiba-Takeuchi. “Significance of Whole-Genome
Duplications on the Emergence of Evolutionary Novelties.” Briefings in Functional
Genomics, vol. 17, no. 5, Oxford University Press, 2018, pp. 329–38, doi:10.1093/bfgp/ely007.
short: M. Yuuta, K. Koshiba-Takeuchi, Briefings in Functional Genomics 17 (2018)
329–338.
date_created: 2022-03-18T12:40:35Z
date_published: 2018-09-01T00:00:00Z
date_updated: 2023-09-19T15:11:22Z
day: '01'
department:
- _id: CaHe
doi: 10.1093/bfgp/ely007
external_id:
isi:
- '000456054400004'
pmid:
- '29579140'
intvolume: ' 17'
isi: 1
issue: '5'
keyword:
- Genetics
- Molecular Biology
- Biochemistry
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/bfgp/ely007
month: '09'
oa: 1
oa_version: Published Version
page: 329-338
pmid: 1
publication: Briefings in Functional Genomics
publication_identifier:
eissn:
- 2041-2657
issn:
- 2041-2649
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Significance of whole-genome duplications on the emergence of evolutionary
novelties
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 17
year: '2018'
...
---
_id: '10881'
abstract:
- lang: eng
text: Strigolactones (SLs) are a relatively recent addition to the list of plant
hormones that control different aspects of plant development. SL signalling is
perceived by an α/β hydrolase, DWARF 14 (D14). A close homolog of D14, KARRIKIN
INSENSTIVE2 (KAI2), is involved in perception of an uncharacterized molecule called
karrikin (KAR). Recent studies in Arabidopsis identified the SUPPRESSOR OF MAX2
1 (SMAX1) and SMAX1-LIKE 7 (SMXL7) to be potential SCF–MAX2 complex-mediated proteasome
targets of KAI2 and D14, respectively. Genetic studies on SMXL7 and SMAX1 demonstrated
distinct developmental roles for each, but very little is known about these repressors
in terms of their sequence features. In this study, we performed an extensive
comparative analysis of SMXLs and determined their phylogenetic and evolutionary
history in the plant lineage. Our results show that SMXL family members can be
sub-divided into four distinct phylogenetic clades/classes, with an ancient SMAX1.
Further, we identified the clade-specific motifs that have evolved and that might
act as determinants of SL-KAR signalling specificity. These specificities resulted
from functional diversities among the clades. Our results suggest that a gradual
co-evolution of SMXL members with their upstream receptors D14/KAI2 provided an
increased specificity to both the SL perception and response in land plants.
acknowledgement: "This project received funding from the European Union’s Horizon
2020 research and innovation programme under the Marie Skłodowska-Curie Actions
and it is co-financed by the South Moravian Region under grant agreement No. 665860
(SS). Access to computing and storage facilities owned by parties and projects contributing
to the national grid infrastructure, MetaCentrum, provided under the program ‘Projects
of Large Infrastructure for Research, Development, and Innovations’ (LM2010005)
was greatly appreciated (RSV). The project was funded by The Ministry of Education,
Youth and Sports/MES of the Czech Republic under the project CEITEC 2020 (LQ1601)
(TN, TRM). JF was supported by the European Research Council (project ERC-2011-StG
20101109-PSDP) and the Czech Science Foundation GAČR (GA13-40637S). We thank Dr
Kamel Chibani for active discussions on the evolutionary analysis and Nandan Mysore
Vardarajan for his critical comments on the manuscript. This article reflects\r\nonly
the authors’ views, and the EU is not responsible for any use that may be made of
the information it contains. "
article_processing_charge: No
article_type: original
author:
- first_name: Taraka Ramji
full_name: Moturu, Taraka Ramji
last_name: Moturu
- first_name: Sravankumar
full_name: Thula, Sravankumar
last_name: Thula
- first_name: Ravi Kumar
full_name: Singh, Ravi Kumar
last_name: Singh
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Radka Svobodová
full_name: Vařeková, Radka Svobodová
last_name: Vařeková
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Sibu
full_name: Simon, Sibu
last_name: Simon
citation:
ama: Moturu TR, Thula S, Singh RK, et al. Molecular evolution and diversification
of the SMXL gene family. Journal of Experimental Botany. 2018;69(9):2367-2378.
doi:10.1093/jxb/ery097
apa: Moturu, T. R., Thula, S., Singh, R. K., Nodzyński, T., Vařeková, R. S., Friml,
J., & Simon, S. (2018). Molecular evolution and diversification of the SMXL
gene family. Journal of Experimental Botany. Oxford University Press. https://doi.org/10.1093/jxb/ery097
chicago: Moturu, Taraka Ramji, Sravankumar Thula, Ravi Kumar Singh, Tomasz Nodzyński,
Radka Svobodová Vařeková, Jiří Friml, and Sibu Simon. “Molecular Evolution and
Diversification of the SMXL Gene Family.” Journal of Experimental Botany.
Oxford University Press, 2018. https://doi.org/10.1093/jxb/ery097.
ieee: T. R. Moturu et al., “Molecular evolution and diversification of the
SMXL gene family,” Journal of Experimental Botany, vol. 69, no. 9. Oxford
University Press, pp. 2367–2378, 2018.
ista: Moturu TR, Thula S, Singh RK, Nodzyński T, Vařeková RS, Friml J, Simon S.
2018. Molecular evolution and diversification of the SMXL gene family. Journal
of Experimental Botany. 69(9), 2367–2378.
mla: Moturu, Taraka Ramji, et al. “Molecular Evolution and Diversification of the
SMXL Gene Family.” Journal of Experimental Botany, vol. 69, no. 9, Oxford
University Press, 2018, pp. 2367–78, doi:10.1093/jxb/ery097.
short: T.R. Moturu, S. Thula, R.K. Singh, T. Nodzyński, R.S. Vařeková, J. Friml,
S. Simon, Journal of Experimental Botany 69 (2018) 2367–2378.
date_created: 2022-03-18T12:43:22Z
date_published: 2018-04-13T00:00:00Z
date_updated: 2025-05-07T11:12:33Z
day: '13'
department:
- _id: JiFr
doi: 10.1093/jxb/ery097
ec_funded: 1
external_id:
isi:
- '000430727000016'
pmid:
- '29538714'
intvolume: ' 69'
isi: 1
issue: '9'
keyword:
- Plant Science
- Physiology
language:
- iso: eng
month: '04'
oa_version: None
page: 2367-2378
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: Journal of Experimental Botany
publication_identifier:
eissn:
- 1460-2431
issn:
- 0022-0957
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular evolution and diversification of the SMXL gene family
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 69
year: '2018'
...
---
_id: '10882'
abstract:
- lang: eng
text: 'We introduce Intelligent Annotation Dialogs for bounding box annotation.
We train an agent to automatically choose a sequence of actions for a human annotator
to produce a bounding box in a minimal amount of time. Specifically, we consider
two actions: box verification [34], where the annotator verifies a box generated
by an object detector, and manual box drawing. We explore two kinds of agents,
one based on predicting the probability that a box will be positively verified,
and the other based on reinforcement learning. We demonstrate that (1) our agents
are able to learn efficient annotation strategies in several scenarios, automatically
adapting to the image difficulty, the desired quality of the boxes, and the detector
strength; (2) in all scenarios the resulting annotation dialogs speed up annotation
compared to manual box drawing alone and box verification alone, while also outperforming
any fixed combination of verification and drawing in most scenarios; (3) in a
realistic scenario where the detector is iteratively re-trained, our agents evolve
a series of strategies that reflect the shifting trade-off between verification
and drawing as the detector grows stronger.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Jasper
full_name: Uijlings, Jasper
last_name: Uijlings
- first_name: Ksenia
full_name: Konyushkova, Ksenia
last_name: Konyushkova
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Vittorio
full_name: Ferrari, Vittorio
last_name: Ferrari
citation:
ama: 'Uijlings J, Konyushkova K, Lampert C, Ferrari V. Learning intelligent dialogs
for bounding box annotation. In: 2018 IEEE/CVF Conference on Computer Vision
and Pattern Recognition. IEEE; 2018:9175-9184. doi:10.1109/cvpr.2018.00956'
apa: 'Uijlings, J., Konyushkova, K., Lampert, C., & Ferrari, V. (2018). Learning
intelligent dialogs for bounding box annotation. In 2018 IEEE/CVF Conference
on Computer Vision and Pattern Recognition (pp. 9175–9184). Salt Lake City,
UT, United States: IEEE. https://doi.org/10.1109/cvpr.2018.00956'
chicago: Uijlings, Jasper, Ksenia Konyushkova, Christoph Lampert, and Vittorio Ferrari.
“Learning Intelligent Dialogs for Bounding Box Annotation.” In 2018 IEEE/CVF
Conference on Computer Vision and Pattern Recognition, 9175–84. IEEE, 2018.
https://doi.org/10.1109/cvpr.2018.00956.
ieee: J. Uijlings, K. Konyushkova, C. Lampert, and V. Ferrari, “Learning intelligent
dialogs for bounding box annotation,” in 2018 IEEE/CVF Conference on Computer
Vision and Pattern Recognition, Salt Lake City, UT, United States, 2018, pp.
9175–9184.
ista: 'Uijlings J, Konyushkova K, Lampert C, Ferrari V. 2018. Learning intelligent
dialogs for bounding box annotation. 2018 IEEE/CVF Conference on Computer Vision
and Pattern Recognition. CVF: Conference on Computer Vision and Pattern Recognition,
9175–9184.'
mla: Uijlings, Jasper, et al. “Learning Intelligent Dialogs for Bounding Box Annotation.”
2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE,
2018, pp. 9175–84, doi:10.1109/cvpr.2018.00956.
short: J. Uijlings, K. Konyushkova, C. Lampert, V. Ferrari, in:, 2018 IEEE/CVF Conference
on Computer Vision and Pattern Recognition, IEEE, 2018, pp. 9175–9184.
conference:
end_date: 2018-06-23
location: Salt Lake City, UT, United States
name: 'CVF: Conference on Computer Vision and Pattern Recognition'
start_date: 2018-06-18
date_created: 2022-03-18T12:45:09Z
date_published: 2018-12-17T00:00:00Z
date_updated: 2023-09-19T15:11:49Z
day: '17'
department:
- _id: ChLa
doi: 10.1109/cvpr.2018.00956
external_id:
arxiv:
- '1712.08087'
isi:
- '000457843609036'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.1712.08087'
month: '12'
oa: 1
oa_version: Preprint
page: 9175-9184
publication: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition
publication_identifier:
eissn:
- 2575-7075
isbn:
- '9781538664209'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Learning intelligent dialogs for bounding box annotation
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '10883'
abstract:
- lang: eng
text: 'Solving parity games, which are equivalent to modal μ-calculus model checking,
is a central algorithmic problem in formal methods, with applications in reactive
synthesis, program repair, verification of branching-time properties, etc. Besides
the standard compu- tation model with the explicit representation of games, another
important theoretical model of computation is that of set-based symbolic algorithms.
Set-based symbolic algorithms use basic set operations and one-step predecessor
operations on the implicit description of games, rather than the explicit representation.
The significance of symbolic algorithms is that they provide scalable algorithms
for large finite-state systems, as well as for infinite-state systems with finite
quotient. Consider parity games on graphs with n vertices and parity conditions
with d priorities. While there is a rich literature of explicit algorithms for
parity games, the main results for set-based symbolic algorithms are as follows:
(a) the basic algorithm that requires O(nd) symbolic operations and O(d) symbolic
space; and (b) an improved algorithm that requires O(nd/3+1) symbolic operations
and O(n) symbolic space. In this work, our contributions are as follows: (1) We
present a black-box set-based symbolic algorithm based on the explicit progress
measure algorithm. Two important consequences of our algorithm are as follows:
(a) a set-based symbolic algorithm for parity games that requires quasi-polynomially
many symbolic operations and O(n) symbolic space; and (b) any future improvement
in progress measure based explicit algorithms immediately imply an efficiency
improvement in our set-based symbolic algorithm for parity games. (2) We present
a set-based symbolic algorithm that requires quasi-polynomially many symbolic
operations and O(d · log n) symbolic space. Moreover, for the important special
case of d ≤ log n, our algorithm requires only polynomially many symbolic operations
and poly-logarithmic symbolic space.'
acknowledgement: 'A. S. is fully supported by the Vienna Science and Technology Fund
(WWTF) through project ICT15-003. K.C. is supported by the Austrian Science Fund
(FWF) NFN Grant No S11407-N23 (RiSE/SHiNE) and an ERC Starting grant (279307: Graph
Games). For M.H the research leading to these results has received funding from
the European Research Council under the European Union’s Seventh Framework Programme
(FP/2007-2013) /ERC Grant Agreement no. 340506.'
alternative_title:
- EPiC Series in Computing
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Wolfgang
full_name: Dvořák, Wolfgang
last_name: Dvořák
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Alexander
full_name: Svozil, Alexander
last_name: Svozil
citation:
ama: 'Chatterjee K, Dvořák W, Henzinger MH, Svozil A. Quasipolynomial set-based
symbolic algorithms for parity games. In: 22nd International Conference on
Logic for Programming, Artificial Intelligence and Reasoning. Vol 57. EasyChair;
2018:233-253. doi:10.29007/5z5k'
apa: 'Chatterjee, K., Dvořák, W., Henzinger, M. H., & Svozil, A. (2018). Quasipolynomial
set-based symbolic algorithms for parity games. In 22nd International Conference
on Logic for Programming, Artificial Intelligence and Reasoning (Vol. 57,
pp. 233–253). Awassa, Ethiopia: EasyChair. https://doi.org/10.29007/5z5k'
chicago: Chatterjee, Krishnendu, Wolfgang Dvořák, Monika H Henzinger, and Alexander
Svozil. “Quasipolynomial Set-Based Symbolic Algorithms for Parity Games.” In 22nd
International Conference on Logic for Programming, Artificial Intelligence and
Reasoning, 57:233–53. EasyChair, 2018. https://doi.org/10.29007/5z5k.
ieee: K. Chatterjee, W. Dvořák, M. H. Henzinger, and A. Svozil, “Quasipolynomial
set-based symbolic algorithms for parity games,” in 22nd International Conference
on Logic for Programming, Artificial Intelligence and Reasoning, Awassa, Ethiopia,
2018, vol. 57, pp. 233–253.
ista: 'Chatterjee K, Dvořák W, Henzinger MH, Svozil A. 2018. Quasipolynomial set-based
symbolic algorithms for parity games. 22nd International Conference on Logic for
Programming, Artificial Intelligence and Reasoning. LPAR: Conference on Logic
for Programming, Artificial Intelligence and Reasoning, EPiC Series in Computing,
vol. 57, 233–253.'
mla: Chatterjee, Krishnendu, et al. “Quasipolynomial Set-Based Symbolic Algorithms
for Parity Games.” 22nd International Conference on Logic for Programming,
Artificial Intelligence and Reasoning, vol. 57, EasyChair, 2018, pp. 233–53,
doi:10.29007/5z5k.
short: K. Chatterjee, W. Dvořák, M.H. Henzinger, A. Svozil, in:, 22nd International
Conference on Logic for Programming, Artificial Intelligence and Reasoning, EasyChair,
2018, pp. 233–253.
conference:
end_date: 2018-11-21
location: Awassa, Ethiopia
name: 'LPAR: Conference on Logic for Programming, Artificial Intelligence and Reasoning'
start_date: 2018-11-17
date_created: 2022-03-18T12:46:32Z
date_published: 2018-10-23T00:00:00Z
date_updated: 2022-07-29T09:24:31Z
day: '23'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.29007/5z5k
ec_funded: 1
external_id:
arxiv:
- '1909.04983'
file:
- access_level: open_access
checksum: 1229aa8640bd6db610c85decf2265480
content_type: application/pdf
creator: dernst
date_created: 2022-05-17T07:51:08Z
date_updated: 2022-05-17T07:51:08Z
file_id: '11392'
file_name: 2018_EPiCs_Chatterjee.pdf
file_size: 720893
relation: main_file
success: 1
file_date_updated: 2022-05-17T07:51:08Z
has_accepted_license: '1'
intvolume: ' 57'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 233-253
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: 22nd International Conference on Logic for Programming, Artificial Intelligence
and Reasoning
publication_identifier:
issn:
- 2398-7340
publication_status: published
publisher: EasyChair
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quasipolynomial set-based symbolic algorithms for parity games
type: conference
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 57
year: '2018'
...
---
_id: '11'
abstract:
- lang: eng
text: We report on a novel strategy to derive mean-field limits of quantum mechanical
systems in which a large number of particles weakly couple to a second-quantized
radiation field. The technique combines the method of counting and the coherent
state approach to study the growth of the correlations among the particles and
in the radiation field. As an instructional example, we derive the Schrödinger–Klein–Gordon
system of equations from the Nelson model with ultraviolet cutoff and possibly
massless scalar field. In particular, we prove the convergence of the reduced
density matrices (of the nonrelativistic particles and the field bosons) associated
with the exact time evolution to the projectors onto the solutions of the Schrödinger–Klein–Gordon
equations in trace norm. Furthermore, we derive explicit bounds on the rate of
convergence of the one-particle reduced density matrix of the nonrelativistic
particles in Sobolev norm.
arxiv: 1
author:
- first_name: Nikolai K
full_name: Leopold, Nikolai K
id: 4BC40BEC-F248-11E8-B48F-1D18A9856A87
last_name: Leopold
orcid: 0000-0002-0495-6822
- first_name: Peter
full_name: Pickl, Peter
last_name: Pickl
citation:
ama: 'Leopold NK, Pickl P. Mean-field limits of particles in interaction with quantised
radiation fields. In: Vol 270. Springer; 2018:185-214. doi:10.1007/978-3-030-01602-9_9'
apa: 'Leopold, N. K., & Pickl, P. (2018). Mean-field limits of particles in
interaction with quantised radiation fields (Vol. 270, pp. 185–214). Presented
at the MaLiQS: Macroscopic Limits of Quantum Systems, Munich, Germany: Springer.
https://doi.org/10.1007/978-3-030-01602-9_9'
chicago: Leopold, Nikolai K, and Peter Pickl. “Mean-Field Limits of Particles in
Interaction with Quantised Radiation Fields,” 270:185–214. Springer, 2018. https://doi.org/10.1007/978-3-030-01602-9_9.
ieee: 'N. K. Leopold and P. Pickl, “Mean-field limits of particles in interaction
with quantised radiation fields,” presented at the MaLiQS: Macroscopic Limits
of Quantum Systems, Munich, Germany, 2018, vol. 270, pp. 185–214.'
ista: 'Leopold NK, Pickl P. 2018. Mean-field limits of particles in interaction
with quantised radiation fields. MaLiQS: Macroscopic Limits of Quantum Systems
vol. 270, 185–214.'
mla: Leopold, Nikolai K., and Peter Pickl. Mean-Field Limits of Particles in
Interaction with Quantised Radiation Fields. Vol. 270, Springer, 2018, pp.
185–214, doi:10.1007/978-3-030-01602-9_9.
short: N.K. Leopold, P. Pickl, in:, Springer, 2018, pp. 185–214.
conference:
end_date: 2017-04-01
location: Munich, Germany
name: 'MaLiQS: Macroscopic Limits of Quantum Systems'
start_date: 2017-03-30
date_created: 2018-12-11T11:44:08Z
date_published: 2018-10-27T00:00:00Z
date_updated: 2021-01-12T06:48:16Z
day: '27'
department:
- _id: RoSe
doi: 10.1007/978-3-030-01602-9_9
ec_funded: 1
external_id:
arxiv:
- '1806.10843'
intvolume: ' 270'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1806.10843
month: '10'
oa: 1
oa_version: Preprint
page: 185 - 214
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication_status: published
publisher: Springer
publist_id: '8045'
quality_controlled: '1'
scopus_import: 1
status: public
title: Mean-field limits of particles in interaction with quantised radiation fields
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 270
year: '2018'
...
---
_id: '12'
abstract:
- lang: eng
text: Molding is a popular mass production method, in which the initial expenses
for the mold are offset by the low per-unit production cost. However, the physical
fabrication constraints of the molding technique commonly restrict the shape of
moldable objects. For a complex shape, a decomposition of the object into moldable
parts is a common strategy to address these constraints, with plastic model kits
being a popular and illustrative example. However, conducting such a decomposition
requires considerable expertise, and it depends on the technical aspects of the
fabrication technique, as well as aesthetic considerations. We present an interactive
technique to create such decompositions for two-piece molding, in which each part
of the object is cast between two rigid mold pieces. Given the surface description
of an object, we decompose its thin-shell equivalent into moldable parts by first
performing a coarse decomposition and then utilizing an active contour model for
the boundaries between individual parts. Formulated as an optimization problem,
the movement of the contours is guided by an energy reflecting fabrication constraints
to ensure the moldability of each part. Simultaneously, the user is provided with
editing capabilities to enforce aesthetic guidelines. Our interactive interface
provides control of the contour positions by allowing, for example, the alignment
of part boundaries with object features. Our technique enables a novel workflow,
as it empowers novice users to explore the design space, and it generates fabrication-ready
two-piece molds that can be used either for casting or industrial injection molding
of free-form objects.
article_number: '135'
article_processing_charge: No
author:
- first_name: Kazutaka
full_name: Nakashima, Kazutaka
last_name: Nakashima
- first_name: Thomas
full_name: Auzinger, Thomas
id: 4718F954-F248-11E8-B48F-1D18A9856A87
last_name: Auzinger
orcid: 0000-0002-1546-3265
- first_name: Emmanuel
full_name: Iarussi, Emmanuel
id: 33F19F16-F248-11E8-B48F-1D18A9856A87
last_name: Iarussi
- first_name: Ran
full_name: Zhang, Ran
id: 4DDBCEB0-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0002-3808-281X
- first_name: Takeo
full_name: Igarashi, Takeo
last_name: Igarashi
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
citation:
ama: 'Nakashima K, Auzinger T, Iarussi E, Zhang R, Igarashi T, Bickel B. CoreCavity:
Interactive shell decomposition for fabrication with two-piece rigid molds. ACM
Transaction on Graphics. 2018;37(4). doi:10.1145/3197517.3201341'
apa: 'Nakashima, K., Auzinger, T., Iarussi, E., Zhang, R., Igarashi, T., & Bickel,
B. (2018). CoreCavity: Interactive shell decomposition for fabrication with two-piece
rigid molds. ACM Transaction on Graphics. ACM. https://doi.org/10.1145/3197517.3201341'
chicago: 'Nakashima, Kazutaka, Thomas Auzinger, Emmanuel Iarussi, Ran Zhang, Takeo
Igarashi, and Bernd Bickel. “CoreCavity: Interactive Shell Decomposition for Fabrication
with Two-Piece Rigid Molds.” ACM Transaction on Graphics. ACM, 2018. https://doi.org/10.1145/3197517.3201341.'
ieee: 'K. Nakashima, T. Auzinger, E. Iarussi, R. Zhang, T. Igarashi, and B. Bickel,
“CoreCavity: Interactive shell decomposition for fabrication with two-piece rigid
molds,” ACM Transaction on Graphics, vol. 37, no. 4. ACM, 2018.'
ista: 'Nakashima K, Auzinger T, Iarussi E, Zhang R, Igarashi T, Bickel B. 2018.
CoreCavity: Interactive shell decomposition for fabrication with two-piece rigid
molds. ACM Transaction on Graphics. 37(4), 135.'
mla: 'Nakashima, Kazutaka, et al. “CoreCavity: Interactive Shell Decomposition for
Fabrication with Two-Piece Rigid Molds.” ACM Transaction on Graphics, vol.
37, no. 4, 135, ACM, 2018, doi:10.1145/3197517.3201341.'
short: K. Nakashima, T. Auzinger, E. Iarussi, R. Zhang, T. Igarashi, B. Bickel,
ACM Transaction on Graphics 37 (2018).
date_created: 2018-12-11T11:44:09Z
date_published: 2018-08-04T00:00:00Z
date_updated: 2023-09-11T12:48:09Z
day: '04'
ddc:
- '004'
- '516'
- '670'
department:
- _id: BeBi
doi: 10.1145/3197517.3201341
ec_funded: 1
external_id:
isi:
- '000448185000096'
file:
- access_level: open_access
checksum: 6a5368bc86c4e1a9fcfe588fd1f14ee8
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:18:38Z
date_updated: 2020-07-14T12:44:38Z
file_id: '5360'
file_name: IST-2018-1037-v1+1_CoreCavity-AuthorVersion.pdf
file_size: 104225664
relation: main_file
- access_level: open_access
checksum: 3861e693ba47c51f3ec7b7867d573a61
content_type: application/zip
creator: system
date_created: 2018-12-12T10:18:39Z
date_updated: 2020-07-14T12:44:38Z
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creator: system
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date_updated: 2020-07-14T12:44:38Z
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file_size: 527972
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intvolume: ' 37'
isi: 1
issue: '4'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
- _id: 2508E324-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '642841'
name: Distributed 3D Object Design
publication: ACM Transaction on Graphics
publication_status: published
publisher: ACM
publist_id: '8044'
pubrep_id: '1037'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/interactive-software-tool-makes-complex-mold-design-simple/
scopus_import: '1'
status: public
title: 'CoreCavity: Interactive shell decomposition for fabrication with two-piece
rigid molds'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 37
year: '2018'
...
---
_id: '21'
abstract:
- lang: eng
text: Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits
are thought to play a key role in several higher network functions, such as feedforward
and feedback inhibition, network oscillations, and pattern separation. Fast lateral
inhibition mediated by GABAergic interneurons may implement a winner-takes-all
mechanism in the hippocampal input layer. However, it is not clear whether the
functional connectivity rules of granule cells (GCs) and interneurons in the dentate
gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings
from up to seven GCs and up to four PV+ interneurons in the dentate gyrus, we
find that connectivity is structured in space, synapse-specific, and enriched
in specific disynaptic motifs. In contrast to the neocortex, lateral inhibition
in the dentate gyrus (in which a GC inhibits neighboring GCs via a PV+ interneuron)
is ~ 10-times more abundant than recurrent inhibition (in which a GC inhibits
itself). Thus, unique connectivity rules may enable the dentate gyrus to perform
specific higher-order computations
acknowledgement: This project received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No 692692) and the Fond zur Förderung der Wissenschaftlichen Forschung
(Z 312-B27, Wittgenstein award), both to P.J..
article_number: '4605'
article_processing_charge: No
article_type: original
author:
- first_name: 'Claudia '
full_name: 'Espinoza Martinez, Claudia '
id: 31FFEE2E-F248-11E8-B48F-1D18A9856A87
last_name: Espinoza Martinez
orcid: 0000-0003-4710-2082
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Xiaomin
full_name: Zhang, Xiaomin
id: 423EC9C2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Espinoza Martinez C, Guzmán J, Zhang X, Jonas PM. Parvalbumin+ interneurons
obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit
in dentate gyrus. Nature Communications. 2018;9(1). doi:10.1038/s41467-018-06899-3
apa: Espinoza Martinez, C., Guzmán, J., Zhang, X., & Jonas, P. M. (2018). Parvalbumin+
interneurons obey unique connectivity rules and establish a powerful lateral-inhibition
microcircuit in dentate gyrus. Nature Communications. Nature Publishing
Group. https://doi.org/10.1038/s41467-018-06899-3
chicago: Espinoza Martinez, Claudia , José Guzmán, Xiaomin Zhang, and Peter M Jonas.
“Parvalbumin+ Interneurons Obey Unique Connectivity Rules and Establish a Powerful
Lateral-Inhibition Microcircuit in Dentate Gyrus.” Nature Communications.
Nature Publishing Group, 2018. https://doi.org/10.1038/s41467-018-06899-3.
ieee: C. Espinoza Martinez, J. Guzmán, X. Zhang, and P. M. Jonas, “Parvalbumin+
interneurons obey unique connectivity rules and establish a powerful lateral-inhibition
microcircuit in dentate gyrus,” Nature Communications, vol. 9, no. 1. Nature
Publishing Group, 2018.
ista: Espinoza Martinez C, Guzmán J, Zhang X, Jonas PM. 2018. Parvalbumin+ interneurons
obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit
in dentate gyrus. Nature Communications. 9(1), 4605.
mla: Espinoza Martinez, Claudia, et al. “Parvalbumin+ Interneurons Obey Unique Connectivity
Rules and Establish a Powerful Lateral-Inhibition Microcircuit in Dentate Gyrus.”
Nature Communications, vol. 9, no. 1, 4605, Nature Publishing Group, 2018,
doi:10.1038/s41467-018-06899-3.
short: C. Espinoza Martinez, J. Guzmán, X. Zhang, P.M. Jonas, Nature Communications
9 (2018).
date_created: 2018-12-11T11:44:12Z
date_published: 2018-11-02T00:00:00Z
date_updated: 2024-03-25T23:30:16Z
day: '02'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/s41467-018-06899-3
ec_funded: 1
external_id:
isi:
- '000449069700009'
file:
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checksum: 9fe2a63bd95a5067d896c087d07998f3
content_type: application/pdf
creator: dernst
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date_updated: 2020-07-14T12:45:28Z
file_id: '5715'
file_name: 2018_NatureComm_Espinoza.pdf
file_size: 4651930
relation: main_file
file_date_updated: 2020-07-14T12:45:28Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '8034'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/lateral-inhibition-keeps-similar-memories-apart/
record:
- id: '6363'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful
lateral-inhibition microcircuit in dentate gyrus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2018'
...
---
_id: '22'
abstract:
- lang: eng
text: Conventional ultra-high sensitivity detectors in the millimeter-wave range
are usually cooled as their own thermal noise at room temperature would mask the
weak received radiation. The need for cryogenic systems increases the cost and
complexity of the instruments, hindering the development of, among others, airborne
and space applications. In this work, the nonlinear parametric upconversion of
millimeter-wave radiation to the optical domain inside high-quality (Q) lithium
niobate whispering-gallery mode (WGM) resonators is proposed for ultra-low noise
detection. We experimentally demonstrate coherent upconversion of millimeter-wave
signals to a 1550 nm telecom carrier, with a photon conversion efficiency surpassing
the state-of-the-art by 2 orders of magnitude. Moreover, a theoretical model shows
that the thermal equilibrium of counterpropagating WGMs is broken by overcoupling
the millimeter-wave WGM, effectively cooling the upconverted mode and allowing
ultra-low noise detection. By theoretically estimating the sensitivity of a correlation
radiometer based on the presented scheme, it is found that room-temperature radiometers
with better sensitivity than state-of-the-art high-electron-mobility transistor
(HEMT)-based radiometers can be designed. This detection paradigm can be used
to develop room-temperature instrumentation for radio astronomy, earth observation,
planetary missions, and imaging systems.
article_processing_charge: No
article_type: original
author:
- first_name: Gabriel
full_name: Botello, Gabriel
last_name: Botello
- first_name: Florian
full_name: Sedlmeir, Florian
last_name: Sedlmeir
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Kerlos
full_name: Abdalmalak, Kerlos
last_name: Abdalmalak
- first_name: Elliott
full_name: Brown, Elliott
last_name: Brown
- first_name: Gerd
full_name: Leuchs, Gerd
last_name: Leuchs
- first_name: Sascha
full_name: Preu, Sascha
last_name: Preu
- first_name: Daniel
full_name: Segovia Vargas, Daniel
last_name: Segovia Vargas
- first_name: Dmitry
full_name: Strekalov, Dmitry
last_name: Strekalov
- first_name: Luis
full_name: Munoz, Luis
last_name: Munoz
- first_name: Harald
full_name: Schwefel, Harald
last_name: Schwefel
citation:
ama: Botello G, Sedlmeir F, Rueda Sanchez AR, et al. Sensitivity limits of millimeter-wave
photonic radiometers based on efficient electro-optic upconverters. Optica.
2018;5(10):1210-1219. doi:10.1364/OPTICA.5.001210
apa: Botello, G., Sedlmeir, F., Rueda Sanchez, A. R., Abdalmalak, K., Brown, E.,
Leuchs, G., … Schwefel, H. (2018). Sensitivity limits of millimeter-wave photonic
radiometers based on efficient electro-optic upconverters. Optica. https://doi.org/10.1364/OPTICA.5.001210
chicago: Botello, Gabriel, Florian Sedlmeir, Alfredo R Rueda Sanchez, Kerlos Abdalmalak,
Elliott Brown, Gerd Leuchs, Sascha Preu, et al. “Sensitivity Limits of Millimeter-Wave
Photonic Radiometers Based on Efficient Electro-Optic Upconverters.” Optica,
2018. https://doi.org/10.1364/OPTICA.5.001210.
ieee: G. Botello et al., “Sensitivity limits of millimeter-wave photonic
radiometers based on efficient electro-optic upconverters,” Optica, vol.
5, no. 10. pp. 1210–1219, 2018.
ista: Botello G, Sedlmeir F, Rueda Sanchez AR, Abdalmalak K, Brown E, Leuchs G,
Preu S, Segovia Vargas D, Strekalov D, Munoz L, Schwefel H. 2018. Sensitivity
limits of millimeter-wave photonic radiometers based on efficient electro-optic
upconverters. Optica. 5(10), 1210–1219.
mla: Botello, Gabriel, et al. “Sensitivity Limits of Millimeter-Wave Photonic Radiometers
Based on Efficient Electro-Optic Upconverters.” Optica, vol. 5, no. 10,
2018, pp. 1210–19, doi:10.1364/OPTICA.5.001210.
short: G. Botello, F. Sedlmeir, A.R. Rueda Sanchez, K. Abdalmalak, E. Brown, G.
Leuchs, S. Preu, D. Segovia Vargas, D. Strekalov, L. Munoz, H. Schwefel, Optica
5 (2018) 1210–1219.
date_created: 2018-12-11T11:44:12Z
date_published: 2018-10-20T00:00:00Z
date_updated: 2023-10-17T12:12:40Z
day: '20'
department:
- _id: JoFi
doi: 10.1364/OPTICA.5.001210
external_id:
isi:
- '000447853100007'
intvolume: ' 5'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'www.doi.org/10.1364/OPTICA.5.001210 '
month: '10'
oa: 1
oa_version: Published Version
page: 1210 - 1219
publication: Optica
publication_identifier:
issn:
- '23342536'
publication_status: published
publist_id: '8033'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sensitivity limits of millimeter-wave photonic radiometers based on efficient
electro-optic upconverters
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2018'
...
---
_id: '23'
abstract:
- lang: eng
text: The strong atomistic spin–orbit coupling of holes makes single-shot spin readout
measurements difficult because it reduces the spin lifetimes. By integrating the
charge sensor into a high bandwidth radio frequency reflectometry setup, we were
able to demonstrate single-shot readout of a germanium quantum dot hole spin and
measure the spin lifetime. Hole spin relaxation times of about 90 μs at 500 mT
are reported, with a total readout visibility of about 70%. By analyzing separately
the spin-to-charge conversion and charge readout fidelities, we have obtained
insight into the processes limiting the visibilities of hole spins. The analyses
suggest that high hole visibilities are feasible at realistic experimental conditions,
underlying the potential of hole spins for the realization of viable qubit devices.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
article_processing_charge: No
author:
- first_name: Lada
full_name: Vukušić, Lada
id: 31E9F056-F248-11E8-B48F-1D18A9856A87
last_name: Vukušić
orcid: 0000-0003-2424-8636
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Hannes
full_name: Watzinger, Hannes
id: 35DF8E50-F248-11E8-B48F-1D18A9856A87
last_name: Watzinger
- first_name: Joshua M
full_name: Milem, Joshua M
id: 4CDE0A96-F248-11E8-B48F-1D18A9856A87
last_name: Milem
- first_name: Friedrich
full_name: Schäffler, Friedrich
last_name: Schäffler
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Vukušić L, Kukucka J, Watzinger H, Milem JM, Schäffler F, Katsaros G. Single-shot
readout of hole spins in Ge. Nano Letters. 2018;18(11):7141-7145. doi:10.1021/acs.nanolett.8b03217
apa: Vukušić, L., Kukucka, J., Watzinger, H., Milem, J. M., Schäffler, F., &
Katsaros, G. (2018). Single-shot readout of hole spins in Ge. Nano Letters.
American Chemical Society. https://doi.org/10.1021/acs.nanolett.8b03217
chicago: Vukušić, Lada, Josip Kukucka, Hannes Watzinger, Joshua M Milem, Friedrich
Schäffler, and Georgios Katsaros. “Single-Shot Readout of Hole Spins in Ge.” Nano
Letters. American Chemical Society, 2018. https://doi.org/10.1021/acs.nanolett.8b03217.
ieee: L. Vukušić, J. Kukucka, H. Watzinger, J. M. Milem, F. Schäffler, and G. Katsaros,
“Single-shot readout of hole spins in Ge,” Nano Letters, vol. 18, no. 11.
American Chemical Society, pp. 7141–7145, 2018.
ista: Vukušić L, Kukucka J, Watzinger H, Milem JM, Schäffler F, Katsaros G. 2018.
Single-shot readout of hole spins in Ge. Nano Letters. 18(11), 7141–7145.
mla: Vukušić, Lada, et al. “Single-Shot Readout of Hole Spins in Ge.” Nano Letters,
vol. 18, no. 11, American Chemical Society, 2018, pp. 7141–45, doi:10.1021/acs.nanolett.8b03217.
short: L. Vukušić, J. Kukucka, H. Watzinger, J.M. Milem, F. Schäffler, G. Katsaros,
Nano Letters 18 (2018) 7141–7145.
date_created: 2018-12-11T11:44:13Z
date_published: 2018-10-25T00:00:00Z
date_updated: 2023-09-18T09:30:37Z
day: '25'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.1021/acs.nanolett.8b03217
ec_funded: 1
external_id:
isi:
- '000451102100064'
pmid:
- '30359041'
file:
- access_level: open_access
checksum: 3e6034a94c6b5335e939145d88bdb371
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:08Z
date_updated: 2020-07-14T12:45:37Z
file_id: '5194'
file_name: IST-2018-1065-v1+1_ACS_nanoletters_8b03217.pdf
file_size: 1361441
relation: main_file
file_date_updated: 2020-07-14T12:45:37Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '11'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 7141 - 7145
pmid: 1
project:
- _id: 25517E86-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '335497'
name: Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires
publication: Nano Letters
publication_identifier:
issn:
- '15306984'
publication_status: published
publisher: American Chemical Society
publist_id: '8032'
pubrep_id: '1065'
quality_controlled: '1'
related_material:
record:
- id: '7977'
relation: popular_science
- id: '69'
relation: dissertation_contains
status: public
- id: '7996'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Single-shot readout of hole spins in Ge
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 18
year: '2018'
...
---
_id: '24'
abstract:
- lang: eng
text: Partially-observable Markov decision processes (POMDPs) with discounted-sum
payoff are a standard framework to model a wide range of problems related to decision
making under uncertainty. Traditionally, the goal has been to obtain policies
that optimize the expectation of the discounted-sum payoff. A key drawback of
the expectation measure is that even low probability events with extreme payoff
can significantly affect the expectation, and thus the obtained policies are not
necessarily risk-averse. An alternate approach is to optimize the probability
that the payoff is above a certain threshold, which allows obtaining risk-averse
policies, but ignores optimization of the expectation. We consider the expectation
optimization with probabilistic guarantee (EOPG) problem, where the goal is to
optimize the expectation ensuring that the payoff is above a given threshold with
at least a specified probability. We present several results on the EOPG problem,
including the first algorithm to solve it.
acknowledgement: "This research was supported by the Vienna Science and Technology
Fund (WWTF) grant ICT15-003; Austrian Science Fund (FWF): S11407-N23(RiSE/SHiNE);and
an ERC Start Grant (279307:Graph Games).\r\n"
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Adrian
full_name: Elgyütt, Adrian
id: 4A2E9DBA-F248-11E8-B48F-1D18A9856A87
last_name: Elgyütt
- first_name: Petr
full_name: Novotny, Petr
id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
last_name: Novotny
- first_name: Owen
full_name: Rouillé, Owen
last_name: Rouillé
citation:
ama: 'Chatterjee K, Elgyütt A, Novotný P, Rouillé O. Expectation optimization with
probabilistic guarantees in POMDPs with discounted-sum objectives. In: Vol 2018.
IJCAI; 2018:4692-4699. doi:10.24963/ijcai.2018/652'
apa: 'Chatterjee, K., Elgyütt, A., Novotný, P., & Rouillé, O. (2018). Expectation
optimization with probabilistic guarantees in POMDPs with discounted-sum objectives
(Vol. 2018, pp. 4692–4699). Presented at the IJCAI: International Joint Conference
on Artificial Intelligence, Stockholm, Sweden: IJCAI. https://doi.org/10.24963/ijcai.2018/652'
chicago: Chatterjee, Krishnendu, Adrian Elgyütt, Petr Novotný, and Owen Rouillé.
“Expectation Optimization with Probabilistic Guarantees in POMDPs with Discounted-Sum
Objectives,” 2018:4692–99. IJCAI, 2018. https://doi.org/10.24963/ijcai.2018/652.
ieee: 'K. Chatterjee, A. Elgyütt, P. Novotný, and O. Rouillé, “Expectation optimization
with probabilistic guarantees in POMDPs with discounted-sum objectives,” presented
at the IJCAI: International Joint Conference on Artificial Intelligence, Stockholm,
Sweden, 2018, vol. 2018, pp. 4692–4699.'
ista: 'Chatterjee K, Elgyütt A, Novotný P, Rouillé O. 2018. Expectation optimization
with probabilistic guarantees in POMDPs with discounted-sum objectives. IJCAI:
International Joint Conference on Artificial Intelligence vol. 2018, 4692–4699.'
mla: Chatterjee, Krishnendu, et al. Expectation Optimization with Probabilistic
Guarantees in POMDPs with Discounted-Sum Objectives. Vol. 2018, IJCAI, 2018,
pp. 4692–99, doi:10.24963/ijcai.2018/652.
short: K. Chatterjee, A. Elgyütt, P. Novotný, O. Rouillé, in:, IJCAI, 2018, pp.
4692–4699.
conference:
end_date: 2018-07-19
location: Stockholm, Sweden
name: 'IJCAI: International Joint Conference on Artificial Intelligence'
start_date: 2018-07-13
date_created: 2018-12-11T11:44:13Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2025-06-02T08:53:48Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.24963/ijcai.2018/652
ec_funded: 1
external_id:
arxiv:
- '1804.10601'
isi:
- '000764175404117'
intvolume: ' 2018'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1804.10601
month: '07'
oa: 1
oa_version: Preprint
page: 4692 - 4699
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication_status: published
publisher: IJCAI
publist_id: '8031'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum
objectives
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2018
year: '2018'
...
---
_id: '25'
abstract:
- lang: eng
text: 'Partially observable Markov decision processes (POMDPs) are the standard
models for planning under uncertainty with both finite and infinite horizon. Besides
the well-known discounted-sum objective, indefinite-horizon objective (aka Goal-POMDPs)
is another classical objective for POMDPs. In this case, given a set of target
states and a positive cost for each transition, the optimization objective is
to minimize the expected total cost until a target state is reached. In the literature,
RTDP-Bel or heuristic search value iteration (HSVI) have been used for solving
Goal-POMDPs. Neither of these algorithms has theoretical convergence guarantees,
and HSVI may even fail to terminate its trials. We give the following contributions:
(1) We discuss the challenges introduced in Goal-POMDPs and illustrate how they
prevent the original HSVI from converging. (2) We present a novel algorithm inspired
by HSVI, termed Goal-HSVI, and show that our algorithm has convergence guarantees.
(3) We show that Goal-HSVI outperforms RTDP-Bel on a set of well-known examples.'
acknowledgement: '∗This work has been supported by Vienna Science and Technology Fund
(WWTF) Project ICT15-003, Austrian Science Fund (FWF) NFN Grant No S11407-N23 (RiSE/SHiNE),
and ERC Starting grant (279307: Graph Games). This research was sponsored by the
Army Research Laboratory and was accomplished under Cooperative Agreement Number
W911NF-13-2-0045 (ARL Cyber Security CRA). '
article_processing_charge: No
author:
- first_name: Karel
full_name: Horák, Karel
last_name: Horák
- first_name: Branislav
full_name: Bošanský, Branislav
last_name: Bošanský
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
citation:
ama: 'Horák K, Bošanský B, Chatterjee K. Goal-HSVI: Heuristic search value iteration
for goal-POMDPs. In: Proceedings of the Twenty-Seventh International Joint
Conference on Artificial Intelligence. Vol 2018-July. IJCAI; 2018:4764-4770.
doi:10.24963/ijcai.2018/662'
apa: 'Horák, K., Bošanský, B., & Chatterjee, K. (2018). Goal-HSVI: Heuristic
search value iteration for goal-POMDPs. In Proceedings of the Twenty-Seventh
International Joint Conference on Artificial Intelligence (Vol. 2018–July,
pp. 4764–4770). Stockholm, Sweden: IJCAI. https://doi.org/10.24963/ijcai.2018/662'
chicago: 'Horák, Karel, Branislav Bošanský, and Krishnendu Chatterjee. “Goal-HSVI:
Heuristic Search Value Iteration for Goal-POMDPs.” In Proceedings of the Twenty-Seventh
International Joint Conference on Artificial Intelligence, 2018–July:4764–70.
IJCAI, 2018. https://doi.org/10.24963/ijcai.2018/662.'
ieee: 'K. Horák, B. Bošanský, and K. Chatterjee, “Goal-HSVI: Heuristic search value
iteration for goal-POMDPs,” in Proceedings of the Twenty-Seventh International
Joint Conference on Artificial Intelligence, Stockholm, Sweden, 2018, vol.
2018–July, pp. 4764–4770.'
ista: 'Horák K, Bošanský B, Chatterjee K. 2018. Goal-HSVI: Heuristic search value
iteration for goal-POMDPs. Proceedings of the Twenty-Seventh International Joint
Conference on Artificial Intelligence. IJCAI: International Joint Conference on
Artificial Intelligence vol. 2018–July, 4764–4770.'
mla: 'Horák, Karel, et al. “Goal-HSVI: Heuristic Search Value Iteration for Goal-POMDPs.”
Proceedings of the Twenty-Seventh International Joint Conference on Artificial
Intelligence, vol. 2018–July, IJCAI, 2018, pp. 4764–70, doi:10.24963/ijcai.2018/662.'
short: K. Horák, B. Bošanský, K. Chatterjee, in:, Proceedings of the Twenty-Seventh
International Joint Conference on Artificial Intelligence, IJCAI, 2018, pp. 4764–4770.
conference:
end_date: 2018-07-19
location: Stockholm, Sweden
name: 'IJCAI: International Joint Conference on Artificial Intelligence'
start_date: 2018-07-13
date_created: 2018-12-11T11:44:13Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2025-06-02T08:53:40Z
day: '01'
department:
- _id: KrCh
doi: 10.24963/ijcai.2018/662
ec_funded: 1
external_id:
isi:
- '000764175404127'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.24963/ijcai.2018/662
month: '07'
oa: 1
oa_version: Published Version
page: 4764 - 4770
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: Proceedings of the Twenty-Seventh International Joint Conference on Artificial
Intelligence
publication_status: published
publisher: IJCAI
publist_id: '8030'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Goal-HSVI: Heuristic search value iteration for goal-POMDPs'
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2018-July
year: '2018'
...
---
_id: '26'
abstract:
- lang: eng
text: Expression of genes is a fundamental molecular phenotype that is subject to
evolution by different types of mutations. Both the rate and the effect of mutations
may depend on the DNA sequence context of a particular gene or a particular promoter
sequence. In this thesis I investigate the nature of this dependence using simple
genetic systems in Escherichia coli. With these systems I explore the evolution
of constitutive gene expression from random starting sequences at different loci
on the chromosome and at different locations in sequence space. First, I dissect
chromosomal neighborhood effects that underlie locus-dependent differences in
the potential of a gene under selection to become more highly expressed. Next,
I find that the effects of point mutations in promoter sequences are dependent
on sequence context, and that an existing energy matrix model performs poorly
in predicting relative expression of unrelated sequences. Finally, I show that
a substantial fraction of random sequences contain functional promoters and I
present an extended thermodynamic model that predicts promoter strength in full
sequence space. Taken together, these results provide new insights and guides
on how to integrate information on sequence context to improve our qualitative
and quantitative understanding of bacterial gene expression, with implications
for rapid evolution of drug resistance, de novo evolution of genes, and horizontal
gene transfer.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Magdalena
full_name: Steinrück, Magdalena
id: 2C023F40-F248-11E8-B48F-1D18A9856A87
last_name: Steinrück
orcid: 0000-0003-1229-9719
citation:
ama: Steinrück M. The influence of sequence context on the evolution of bacterial
gene expression. 2018. doi:10.15479/AT:ISTA:th1059
apa: Steinrück, M. (2018). The influence of sequence context on the evolution
of bacterial gene expression. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:th1059
chicago: Steinrück, Magdalena. “The Influence of Sequence Context on the Evolution
of Bacterial Gene Expression.” Institute of Science and Technology Austria, 2018.
https://doi.org/10.15479/AT:ISTA:th1059.
ieee: M. Steinrück, “The influence of sequence context on the evolution of bacterial
gene expression,” Institute of Science and Technology Austria, 2018.
ista: Steinrück M. 2018. The influence of sequence context on the evolution of bacterial
gene expression. Institute of Science and Technology Austria.
mla: Steinrück, Magdalena. The Influence of Sequence Context on the Evolution
of Bacterial Gene Expression. Institute of Science and Technology Austria,
2018, doi:10.15479/AT:ISTA:th1059.
short: M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial
Gene Expression, Institute of Science and Technology Austria, 2018.
date_created: 2018-12-11T11:44:14Z
date_published: 2018-10-30T00:00:00Z
date_updated: 2023-09-07T12:48:43Z
day: '30'
ddc:
- '576'
- '579'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:th1059
file:
- access_level: closed
checksum: 413cbce1cd1debeae3abe2a25dbc70d1
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-02-08T10:51:22Z
date_updated: 2020-07-14T12:45:43Z
embargo_to: open_access
file_id: '5941'
file_name: Thesis_Steinrueck_final.docx
file_size: 9190845
relation: source_file
- access_level: open_access
checksum: 3def8b7854c8b42d643597ce0215efac
content_type: application/pdf
creator: dernst
date_created: 2019-02-08T10:51:22Z
date_updated: 2021-02-11T11:17:14Z
embargo: 2019-11-02
file_id: '5942'
file_name: Thesis_Steinrueck_final.pdf
file_size: 7521973
relation: main_file
file_date_updated: 2021-02-11T11:17:14Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '109'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8029'
pubrep_id: '1059'
related_material:
record:
- id: '704'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
title: The influence of sequence context on the evolution of bacterial gene expression
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '273'
abstract:
- lang: eng
text: The accuracy of information retrieval systems is often measured using complex
loss functions such as the average precision (AP) or the normalized discounted
cumulative gain (NDCG). Given a set of positive and negative samples, the parameters
of a retrieval system can be estimated by minimizing these loss functions. However,
the non-differentiability and non-decomposability of these loss functions does
not allow for simple gradient based optimization algorithms. This issue is generally
circumvented by either optimizing a structured hinge-loss upper bound to the loss
function or by using asymptotic methods like the direct-loss minimization framework.
Yet, the high computational complexity of loss-augmented inference, which is necessary
for both the frameworks, prohibits its use in large training data sets. To alleviate
this deficiency, we present a novel quicksort flavored algorithm for a large class
of non-decomposable loss functions. We provide a complete characterization of
the loss functions that are amenable to our algorithm, and show that it includes
both AP and NDCG based loss functions. Furthermore, we prove that no comparison
based algorithm can improve upon the computational complexity of our approach
asymptotically. We demonstrate the effectiveness of our approach in the context
of optimizing the structured hinge loss upper bound of AP and NDCG loss for learning
models for a variety of vision tasks. We show that our approach provides significantly
better results than simpler decomposable loss functions, while requiring a comparable
training time.
article_processing_charge: No
arxiv: 1
author:
- first_name: Pritish
full_name: Mohapatra, Pritish
last_name: Mohapatra
- first_name: Michal
full_name: Rolinek, Michal
id: 3CB3BC06-F248-11E8-B48F-1D18A9856A87
last_name: Rolinek
- first_name: C V
full_name: Jawahar, C V
last_name: Jawahar
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: M Pawan
full_name: Kumar, M Pawan
last_name: Kumar
citation:
ama: 'Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. Efficient optimization
for rank-based loss functions. In: 2018 IEEE/CVF Conference on Computer Vision
and Pattern Recognition. IEEE; 2018:3693-3701. doi:10.1109/cvpr.2018.00389'
apa: 'Mohapatra, P., Rolinek, M., Jawahar, C. V., Kolmogorov, V., & Kumar, M.
P. (2018). Efficient optimization for rank-based loss functions. In 2018 IEEE/CVF
Conference on Computer Vision and Pattern Recognition (pp. 3693–3701). Salt
Lake City, UT, USA: IEEE. https://doi.org/10.1109/cvpr.2018.00389'
chicago: Mohapatra, Pritish, Michal Rolinek, C V Jawahar, Vladimir Kolmogorov, and
M Pawan Kumar. “Efficient Optimization for Rank-Based Loss Functions.” In 2018
IEEE/CVF Conference on Computer Vision and Pattern Recognition, 3693–3701.
IEEE, 2018. https://doi.org/10.1109/cvpr.2018.00389.
ieee: P. Mohapatra, M. Rolinek, C. V. Jawahar, V. Kolmogorov, and M. P. Kumar, “Efficient
optimization for rank-based loss functions,” in 2018 IEEE/CVF Conference on
Computer Vision and Pattern Recognition, Salt Lake City, UT, USA, 2018, pp.
3693–3701.
ista: 'Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. 2018. Efficient
optimization for rank-based loss functions. 2018 IEEE/CVF Conference on Computer
Vision and Pattern Recognition. CVPR: Conference on Computer Vision and Pattern
Recognition, 3693–3701.'
mla: Mohapatra, Pritish, et al. “Efficient Optimization for Rank-Based Loss Functions.”
2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE,
2018, pp. 3693–701, doi:10.1109/cvpr.2018.00389.
short: P. Mohapatra, M. Rolinek, C.V. Jawahar, V. Kolmogorov, M.P. Kumar, in:, 2018
IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE, 2018, pp.
3693–3701.
conference:
end_date: 2018-06-22
location: Salt Lake City, UT, USA
name: 'CVPR: Conference on Computer Vision and Pattern Recognition'
start_date: 2018-06-18
date_created: 2018-12-11T11:45:33Z
date_published: 2018-06-28T00:00:00Z
date_updated: 2023-09-11T13:24:43Z
day: '28'
department:
- _id: VlKo
doi: 10.1109/cvpr.2018.00389
ec_funded: 1
external_id:
arxiv:
- '1604.08269'
isi:
- '000457843603087'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1604.08269
month: '06'
oa: 1
oa_version: Preprint
page: 3693-3701
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition
publication_identifier:
isbn:
- '9781538664209'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient optimization for rank-based loss functions
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '275'
abstract:
- lang: eng
text: Lymphatic endothelial cells (LECs) release extracellular chemokines to guide
the migration of dendritic cells. In this study, we report that LECs also release
basolateral exosome-rich endothelial vesicles (EEVs) that are secreted in greater
numbers in the presence of inflammatory cytokines and accumulate in the perivascular
stroma of small lymphatic vessels in human chronic inflammatory diseases. Proteomic
analyses of EEV fractions identified > 1,700 cargo proteins and revealed a
dominant motility-promoting protein signature. In vitro and ex vivo EEV fractions
augmented cellular protrusion formation in a CX3CL1/fractalkine-dependent fashion
and enhanced the directional migratory response of human dendritic cells along
guidance cues. We conclude that perilymphatic LEC exosomes enhance exploratory
behavior and thus promote directional migration of CX3CR1-expressing cells in
complex tissue environments.
acknowledgement: M. Brown was supported by the Cell Communication in Health and Disease
Graduate Study Program of the Austrian Science Fund and Medizinische Universität
Wien, M. Sixt by the European Research Council (ERC GA 281556) and an Austrian Science
Fund START award, K.L. Bennett by the Austrian Academy of Sciences, D.G. Jackson
and L.A. Johnson by Unit Funding (MC_UU_12010/2) and project grants from the Medical
Research Council (G1100134 and MR/L008610/1), and M. Detmar by the Schweizerischer
Nationalfonds zur Förderung der Wissenschaftlichen Forschung and Advanced European
Research Council grant LYVICAM. K. Vaahtomeri was supported by an Academy of Finland
postdoctoral research grant (287853). This project has received funding from the
European Union’s Horizon 2020 research and innovation program under grant agreement
No. 668036 (RELENT).
article_processing_charge: No
author:
- first_name: Markus
full_name: Brown, Markus
id: 3DAB9AFC-F248-11E8-B48F-1D18A9856A87
last_name: Brown
- first_name: Louise
full_name: Johnson, Louise
last_name: Johnson
- first_name: Dario
full_name: Leone, Dario
last_name: Leone
- first_name: Peter
full_name: Májek, Peter
last_name: Májek
- first_name: Kari
full_name: Vaahtomeri, Kari
id: 368EE576-F248-11E8-B48F-1D18A9856A87
last_name: Vaahtomeri
orcid: 0000-0001-7829-3518
- first_name: Daniel
full_name: Senfter, Daniel
last_name: Senfter
- first_name: Nora
full_name: Bukosza, Nora
last_name: Bukosza
- first_name: Helga
full_name: Schachner, Helga
last_name: Schachner
- first_name: Gabriele
full_name: Asfour, Gabriele
last_name: Asfour
- first_name: Brigitte
full_name: Langer, Brigitte
last_name: Langer
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Katja
full_name: Parapatics, Katja
last_name: Parapatics
- first_name: Young
full_name: Hong, Young
last_name: Hong
- first_name: Keiryn
full_name: Bennett, Keiryn
last_name: Bennett
- first_name: Renate
full_name: Kain, Renate
last_name: Kain
- first_name: Michael
full_name: Detmar, Michael
last_name: Detmar
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: David
full_name: Jackson, David
last_name: Jackson
- first_name: Dontscho
full_name: Kerjaschki, Dontscho
last_name: Kerjaschki
citation:
ama: Brown M, Johnson L, Leone D, et al. Lymphatic exosomes promote dendritic cell
migration along guidance cues. Journal of Cell Biology. 2018;217(6):2205-2221.
doi:10.1083/jcb.201612051
apa: Brown, M., Johnson, L., Leone, D., Májek, P., Vaahtomeri, K., Senfter, D.,
… Kerjaschki, D. (2018). Lymphatic exosomes promote dendritic cell migration along
guidance cues. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201612051
chicago: Brown, Markus, Louise Johnson, Dario Leone, Peter Májek, Kari Vaahtomeri,
Daniel Senfter, Nora Bukosza, et al. “Lymphatic Exosomes Promote Dendritic Cell
Migration along Guidance Cues.” Journal of Cell Biology. Rockefeller University
Press, 2018. https://doi.org/10.1083/jcb.201612051.
ieee: M. Brown et al., “Lymphatic exosomes promote dendritic cell migration
along guidance cues,” Journal of Cell Biology, vol. 217, no. 6. Rockefeller
University Press, pp. 2205–2221, 2018.
ista: Brown M, Johnson L, Leone D, Májek P, Vaahtomeri K, Senfter D, Bukosza N,
Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong Y, Bennett K,
Kain R, Detmar M, Sixt MK, Jackson D, Kerjaschki D. 2018. Lymphatic exosomes promote
dendritic cell migration along guidance cues. Journal of Cell Biology. 217(6),
2205–2221.
mla: Brown, Markus, et al. “Lymphatic Exosomes Promote Dendritic Cell Migration
along Guidance Cues.” Journal of Cell Biology, vol. 217, no. 6, Rockefeller
University Press, 2018, pp. 2205–21, doi:10.1083/jcb.201612051.
short: M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza,
H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett,
R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology
217 (2018) 2205–2221.
date_created: 2018-12-11T11:45:33Z
date_published: 2018-04-12T00:00:00Z
date_updated: 2023-09-13T08:51:29Z
day: '12'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
doi: 10.1083/jcb.201612051
ec_funded: 1
external_id:
isi:
- '000438077800026'
pmid:
- '29650776'
file:
- access_level: open_access
checksum: 9c7eba51a35c62da8c13f98120b64df4
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T12:50:07Z
date_updated: 2020-07-14T12:45:45Z
file_id: '5704'
file_name: 2018_JournalCellBiology_Brown.pdf
file_size: 2252043
relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: ' 217'
isi: 1
issue: '6'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 2205 - 2221
pmid: 1
project:
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 564-B12
name: Cytoskeletal force generation and transduction of leukocytes (FWF)
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
(EU)
publication: Journal of Cell Biology
publication_status: published
publisher: Rockefeller University Press
publist_id: '7627'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lymphatic exosomes promote dendritic cell migration along guidance cues
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 217
year: '2018'
...
---
_id: '276'
abstract:
- lang: eng
text: Directed migration of cells relies on their ability to sense directional guidance
cues and to interact with pericellular structures in order to transduce contractile
cytoskeletal- into mechanical forces. These biomechanical processes depend highly
on microenvironmental factors such as exposure to 2D surfaces or 3D matrices.
In vivo, the majority of cells are exposed to 3D environments. Data on 3D cell
migration are mostly derived from intravital microscopy or collagen-based in vitro
assays. Both approaches offer only limited controlla-bility of experimental conditions.
Here, we developed an automated microfluidic system that allows positioning of
cells in 3D microenvironments containing highly controlled diffusion-based chemokine
gradients. Tracking migration in such gradients was feasible in real time at the
single cell level. Moreover, the setup allowed on-chip immunocytochemistry and
thus linking of functional with phenotypical properties in individual cells. Spatially
defined retrieval of cells from the device allows down-stream off-chip analysis.
Using dendritic cells as a model, our setup specifically allowed us for the first
time to quantitate key migration characteristics of cells exposed to identical
gradients of the chemokine CCL19 yet placed on 2D vs in 3D environments. Migration
properties between 2D and 3D migration were distinct. Morphological features of
cells migrating in an in vitro 3D environment were similar to those of cells migrating
in animal tissues, but different from cells migrating on a surface. Our system
thus offers a highly controllable in vitro-mimic of a 3D environment that cells
traffic in vivo.
acknowledgement: This work was supported by the Swiss National Science Foundation
(MD-PhD fellowships, 323530_164221 to C.F.; and 323630_151483 to A.J.; grant PZ00P3_144863
to M.R, grant 31003A_156431 to T.S.; PZ00P3_148000 to C.T.B.; PZ00P3_154733 to M.M.),
a Novartis “FreeNovation” grant to M.M. and T.S. and an EMBO long-term fellowship
(ALTF 1396-2014) co-funded by the European Commission (LTFCOFUND2013, GA-2013-609409)
to J.R.. M.R. was supported by the Gebert Rüf Foundation (GRS 058/14). The funders
had no role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
article_number: e0198330
article_processing_charge: No
article_type: original
author:
- first_name: Corina
full_name: Frick, Corina
last_name: Frick
- first_name: Philip
full_name: Dettinger, Philip
last_name: Dettinger
- first_name: Jörg
full_name: Renkawitz, Jörg
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
- first_name: Annaïse
full_name: Jauch, Annaïse
last_name: Jauch
- first_name: Christoph
full_name: Berger, Christoph
last_name: Berger
- first_name: Mike
full_name: Recher, Mike
last_name: Recher
- first_name: Timm
full_name: Schroeder, Timm
last_name: Schroeder
- first_name: Matthias
full_name: Mehling, Matthias
last_name: Mehling
citation:
ama: Frick C, Dettinger P, Renkawitz J, et al. Nano-scale microfluidics to study
3D chemotaxis at the single cell level. PLoS One. 2018;13(6). doi:10.1371/journal.pone.0198330
apa: Frick, C., Dettinger, P., Renkawitz, J., Jauch, A., Berger, C., Recher, M.,
… Mehling, M. (2018). Nano-scale microfluidics to study 3D chemotaxis at the single
cell level. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0198330
chicago: Frick, Corina, Philip Dettinger, Jörg Renkawitz, Annaïse Jauch, Christoph
Berger, Mike Recher, Timm Schroeder, and Matthias Mehling. “Nano-Scale Microfluidics
to Study 3D Chemotaxis at the Single Cell Level.” PLoS One. Public Library
of Science, 2018. https://doi.org/10.1371/journal.pone.0198330.
ieee: C. Frick et al., “Nano-scale microfluidics to study 3D chemotaxis at
the single cell level,” PLoS One, vol. 13, no. 6. Public Library of Science,
2018.
ista: Frick C, Dettinger P, Renkawitz J, Jauch A, Berger C, Recher M, Schroeder
T, Mehling M. 2018. Nano-scale microfluidics to study 3D chemotaxis at the single
cell level. PLoS One. 13(6), e0198330.
mla: Frick, Corina, et al. “Nano-Scale Microfluidics to Study 3D Chemotaxis at the
Single Cell Level.” PLoS One, vol. 13, no. 6, e0198330, Public Library
of Science, 2018, doi:10.1371/journal.pone.0198330.
short: C. Frick, P. Dettinger, J. Renkawitz, A. Jauch, C. Berger, M. Recher, T.
Schroeder, M. Mehling, PLoS One 13 (2018).
date_created: 2018-12-11T11:45:34Z
date_published: 2018-06-07T00:00:00Z
date_updated: 2023-09-13T09:00:15Z
day: '07'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1371/journal.pone.0198330
external_id:
isi:
- '000434384900031'
file:
- access_level: open_access
checksum: 95fc5dc3938b3ad3b7697d10c83cc143
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T14:10:32Z
date_updated: 2020-07-14T12:45:45Z
file_id: '5709'
file_name: 2018_Plos_Frick.pdf
file_size: 7682167
relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '7626'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nano-scale microfluidics to study 3D chemotaxis at the single cell level
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13
year: '2018'
...
---
_id: '277'
abstract:
- lang: eng
text: 'Arabidopsis and human ARM protein interact with telomerase. Deregulated mRNA
levels of DNA repair and ribosomal protein genes in an Arabidopsis arm mutant
suggest non-telomeric ARM function. The human homolog ARMC6 interacts with hTRF2.
Abstract: Telomerase maintains telomeres and has proposed non-telomeric functions.
We previously identified interaction of the C-terminal domain of Arabidopsis telomerase
reverse transcriptase (AtTERT) with an armadillo/β-catenin-like repeat (ARM) containing
protein. Here we explore protein–protein interactions of the ARM protein, AtTERT
domains, POT1a, TRF-like family and SMH family proteins, and the chromatin remodeling
protein CHR19 using bimolecular fluorescence complementation (BiFC), yeast two-hybrid
(Y2H) analysis, and co-immunoprecipitation. The ARM protein interacts with both
the N- and C-terminal domains of AtTERT in different cellular compartments. ARM
interacts with CHR19 and TRF-like I family proteins that also bind AtTERT directly
or through interaction with POT1a. The putative human ARM homolog co-precipitates
telomerase activity and interacts with hTRF2 protein in vitro. Analysis of Arabidopsis
arm mutants shows no obvious changes in telomere length or telomerase activity,
suggesting that ARM is not essential for telomere maintenance. The observed interactions
with telomerase and Myb-like domain proteins (TRF-like family I) may therefore
reflect possible non-telomeric functions. Transcript levels of several DNA repair
and ribosomal genes are affected in arm mutants, and ARM, likely in association
with other proteins, suppressed expression of XRCC3 and RPSAA promoter constructs
in luciferase reporter assays. In conclusion, ARM can participate in non-telomeric
functions of telomerase, and can also perform its own telomerase-independent functions.'
article_processing_charge: No
article_type: original
author:
- first_name: Ladislav
full_name: Dokládal, Ladislav
last_name: Dokládal
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: David
full_name: Honys, David
last_name: Honys
- first_name: Nikoleta
full_name: Dupláková, Nikoleta
last_name: Dupláková
- first_name: Lan
full_name: Lee, Lan
last_name: Lee
- first_name: Stanton
full_name: Gelvin, Stanton
last_name: Gelvin
- first_name: Eva
full_name: Sýkorová, Eva
last_name: Sýkorová
citation:
ama: Dokládal L, Benková E, Honys D, et al. An armadillo-domain protein participates
in a telomerase interaction network. Plant Molecular Biology. 2018;97(5):407-420.
doi:10.1007/s11103-018-0747-4
apa: Dokládal, L., Benková, E., Honys, D., Dupláková, N., Lee, L., Gelvin, S., &
Sýkorová, E. (2018). An armadillo-domain protein participates in a telomerase
interaction network. Plant Molecular Biology. Springer. https://doi.org/10.1007/s11103-018-0747-4
chicago: Dokládal, Ladislav, Eva Benková, David Honys, Nikoleta Dupláková, Lan Lee,
Stanton Gelvin, and Eva Sýkorová. “An Armadillo-Domain Protein Participates in
a Telomerase Interaction Network.” Plant Molecular Biology. Springer, 2018.
https://doi.org/10.1007/s11103-018-0747-4.
ieee: L. Dokládal et al., “An armadillo-domain protein participates in a
telomerase interaction network,” Plant Molecular Biology, vol. 97, no.
5. Springer, pp. 407–420, 2018.
ista: Dokládal L, Benková E, Honys D, Dupláková N, Lee L, Gelvin S, Sýkorová E.
2018. An armadillo-domain protein participates in a telomerase interaction network.
Plant Molecular Biology. 97(5), 407–420.
mla: Dokládal, Ladislav, et al. “An Armadillo-Domain Protein Participates in a Telomerase
Interaction Network.” Plant Molecular Biology, vol. 97, no. 5, Springer,
2018, pp. 407–20, doi:10.1007/s11103-018-0747-4.
short: L. Dokládal, E. Benková, D. Honys, N. Dupláková, L. Lee, S. Gelvin, E. Sýkorová,
Plant Molecular Biology 97 (2018) 407–420.
date_created: 2018-12-11T11:45:34Z
date_published: 2018-06-12T00:00:00Z
date_updated: 2023-09-08T13:21:05Z
day: '12'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1007/s11103-018-0747-4
external_id:
isi:
- '000438981700009'
file:
- access_level: open_access
checksum: 451ae47616e6af2533099f596b2a47fb
content_type: application/pdf
creator: dernst
date_created: 2020-05-14T12:23:08Z
date_updated: 2020-07-14T12:45:45Z
file_id: '7834'
file_name: 2018_PlantMolecBio_Dokladal.pdf
file_size: 1150679
relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: ' 97'
isi: 1
issue: '5'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 407 - 420
publication: Plant Molecular Biology
publication_status: published
publisher: Springer
publist_id: '7625'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An armadillo-domain protein participates in a telomerase interaction network
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 97
year: '2018'
...