---
_id: '8168'
abstract:
- lang: eng
  text: Speciation, that is, the evolution of reproductive barriers eventually leading
    to complete isolation, is a crucial process generating biodiversity. Recent work
    has contributed much to our understanding of how reproductive barriers begin to
    evolve, and how they are maintained in the face of gene flow. However, little
    is known about the transition from partial to strong reproductive isolation (RI)
    and the completion of speciation. We argue that the evolution of strong RI is
    likely to involve different processes, or new interactions among processes, compared
    with the evolution of the first reproductive barriers. Transition to strong RI
    may be brought about by changing external conditions, for example, following secondary
    contact. However, the increasing levels of RI themselves create opportunities
    for new barriers to evolve and, and interaction or coupling among barriers. These
    changing processes may depend on genomic architecture and leave detectable signals
    in the genome. We outline outstanding questions and suggest more theoretical and
    empirical work, considering both patterns and processes associated with strong
    RI, is needed to understand how speciation is completed.
article_number: '20190528'
article_processing_charge: No
article_type: original
author:
- first_name: Jonna
  full_name: Kulmuni, Jonna
  last_name: Kulmuni
- first_name: Roger K.
  full_name: Butlin, Roger K.
  last_name: Butlin
- first_name: Kay
  full_name: Lucek, Kay
  last_name: Lucek
- first_name: Vincent
  full_name: Savolainen, Vincent
  last_name: Savolainen
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
citation:
  ama: 'Kulmuni J, Butlin RK, Lucek K, Savolainen V, Westram AM. Towards the completion
    of speciation: The evolution of reproductive isolation beyond the first barriers.
    <i>Philosophical Transactions of the Royal Society Series B: Biological sciences</i>.
    2020;375(1806). doi:<a href="https://doi.org/10.1098/rstb.2019.0528">10.1098/rstb.2019.0528</a>'
  apa: 'Kulmuni, J., Butlin, R. K., Lucek, K., Savolainen, V., &#38; Westram, A. M.
    (2020). Towards the completion of speciation: The evolution of reproductive isolation
    beyond the first barriers. <i>Philosophical Transactions of the Royal Society.
    Series B: Biological Sciences</i>. The Royal Society. <a href="https://doi.org/10.1098/rstb.2019.0528">https://doi.org/10.1098/rstb.2019.0528</a>'
  chicago: 'Kulmuni, Jonna, Roger K. Butlin, Kay Lucek, Vincent Savolainen, and Anja
    M Westram. “Towards the Completion of Speciation: The Evolution of Reproductive
    Isolation beyond the First Barriers.” <i>Philosophical Transactions of the Royal
    Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href="https://doi.org/10.1098/rstb.2019.0528">https://doi.org/10.1098/rstb.2019.0528</a>.'
  ieee: 'J. Kulmuni, R. K. Butlin, K. Lucek, V. Savolainen, and A. M. Westram, “Towards
    the completion of speciation: The evolution of reproductive isolation beyond the
    first barriers,” <i>Philosophical Transactions of the Royal Society. Series B:
    Biological sciences</i>, vol. 375, no. 1806. The Royal Society, 2020.'
  ista: 'Kulmuni J, Butlin RK, Lucek K, Savolainen V, Westram AM. 2020. Towards the
    completion of speciation: The evolution of reproductive isolation beyond the first
    barriers. Philosophical Transactions of the Royal Society. Series B: Biological
    sciences. 375(1806), 20190528.'
  mla: 'Kulmuni, Jonna, et al. “Towards the Completion of Speciation: The Evolution
    of Reproductive Isolation beyond the First Barriers.” <i>Philosophical Transactions
    of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190528,
    The Royal Society, 2020, doi:<a href="https://doi.org/10.1098/rstb.2019.0528">10.1098/rstb.2019.0528</a>.'
  short: 'J. Kulmuni, R.K. Butlin, K. Lucek, V. Savolainen, A.M. Westram, Philosophical
    Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).'
date_created: 2020-07-26T22:01:01Z
date_published: 2020-07-12T00:00:00Z
date_updated: 2023-08-22T08:21:31Z
day: '12'
department:
- _id: NiBa
doi: 10.1098/rstb.2019.0528
ec_funded: 1
external_id:
  isi:
  - '000552662100001'
  pmid:
  - '32654637'
intvolume: '       375'
isi: 1
issue: '1806'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1098/rstb.2019.0528
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 265B41B8-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '797747'
  name: Theoretical and empirical approaches to understanding Parallel Adaptation
publication: 'Philosophical Transactions of the Royal Society. Series B: Biological
  sciences'
publication_identifier:
  eissn:
  - 1471-2970
  issn:
  - 0962-8436
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Towards the completion of speciation: The evolution of reproductive isolation
  beyond the first barriers'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 375
year: '2020'
...
---
_id: '8169'
abstract:
- lang: eng
  text: Many recent studies have addressed the mechanisms operating during the early
    stages of speciation, but surprisingly few studies have tested theoretical predictions
    on the evolution of strong reproductive isolation (RI). To help address this gap,
    we first undertook a quantitative review of the hybrid zone literature for flowering
    plants in relation to reproductive barriers. Then, using Populus as an exemplary
    model group, we analysed genome-wide variation for phylogenetic tree topologies
    in both early- and late-stage speciation taxa to determine how these patterns
    may be related to the genomic architecture of RI. Our plant literature survey
    revealed variation in barrier complexity and an association between barrier number
    and introgressive gene flow. Focusing on Populus, our genome-wide analysis of
    tree topologies in speciating poplar taxa points to unusually complex genomic
    architectures of RI, consistent with earlier genome-wide association studies.
    These architectures appear to facilitate the ‘escape’ of introgressed genome segments
    from polygenic barriers even with strong RI, thus affecting their relationships
    with recombination rates. Placed within the context of the broader literature,
    our data illustrate how phylogenomic approaches hold great promise for addressing
    the evolution and temporary breakdown of RI during late stages of speciation.
acknowledgement: This work was supported by a fellowship from the China Scholarship
  Council (CSC) to H.S., Swiss National Science Foundation (SNF) grant no. 31003A_149306
  to C.L., doctoral programme grant W1225-B20 to a faculty team including C.L., and
  the University of Vienna. We thank members of J.L.’s lab for collecting samples,
  Michael Barfuss and Elfi Grasserbauer for help in the laboratory, the Next Generation
  Sequencing Platform of the University of Berne for sequencing, the Vienna Scientific
  Cluster (VSC) for access to computational resources, and Claus Vogel and members
  of the PopGen Vienna graduate school for helpful discussions.
article_number: '20190544'
article_processing_charge: No
article_type: original
author:
- first_name: Huiying
  full_name: Shang, Huiying
  last_name: Shang
- first_name: Jaqueline
  full_name: Hess, Jaqueline
  last_name: Hess
- first_name: Melinda
  full_name: Pickup, Melinda
  id: 2C78037E-F248-11E8-B48F-1D18A9856A87
  last_name: Pickup
  orcid: 0000-0001-6118-0541
- first_name: David
  full_name: Field, David
  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
  orcid: 0000-0002-4014-8478
- first_name: Pär K.
  full_name: Ingvarsson, Pär K.
  last_name: Ingvarsson
- first_name: Jianquan
  full_name: Liu, Jianquan
  last_name: Liu
- first_name: Christian
  full_name: Lexer, Christian
  last_name: Lexer
citation:
  ama: 'Shang H, Hess J, Pickup M, et al. Evolution of strong reproductive isolation
    in plants: Broad-scale patterns and lessons from a perennial model group. <i>Philosophical
    Transactions of the Royal Society Series B: Biological Sciences</i>. 2020;375(1806).
    doi:<a href="https://doi.org/10.1098/rstb.2019.0544">10.1098/rstb.2019.0544</a>'
  apa: 'Shang, H., Hess, J., Pickup, M., Field, D., Ingvarsson, P. K., Liu, J., &#38;
    Lexer, C. (2020). Evolution of strong reproductive isolation in plants: Broad-scale
    patterns and lessons from a perennial model group. <i>Philosophical Transactions
    of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a
    href="https://doi.org/10.1098/rstb.2019.0544">https://doi.org/10.1098/rstb.2019.0544</a>'
  chicago: 'Shang, Huiying, Jaqueline Hess, Melinda Pickup, David Field, Pär K. Ingvarsson,
    Jianquan Liu, and Christian Lexer. “Evolution of Strong Reproductive Isolation
    in Plants: Broad-Scale Patterns and Lessons from a Perennial Model Group.” <i>Philosophical
    Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal
    Society, 2020. <a href="https://doi.org/10.1098/rstb.2019.0544">https://doi.org/10.1098/rstb.2019.0544</a>.'
  ieee: 'H. Shang <i>et al.</i>, “Evolution of strong reproductive isolation in plants:
    Broad-scale patterns and lessons from a perennial model group,” <i>Philosophical
    Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375,
    no. 1806. The Royal Society, 2020.'
  ista: 'Shang H, Hess J, Pickup M, Field D, Ingvarsson PK, Liu J, Lexer C. 2020.
    Evolution of strong reproductive isolation in plants: Broad-scale patterns and
    lessons from a perennial model group. Philosophical Transactions of the Royal
    Society. Series B: Biological Sciences. 375(1806), 20190544.'
  mla: 'Shang, Huiying, et al. “Evolution of Strong Reproductive Isolation in Plants:
    Broad-Scale Patterns and Lessons from a Perennial Model Group.” <i>Philosophical
    Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375,
    no. 1806, 20190544, The Royal Society, 2020, doi:<a href="https://doi.org/10.1098/rstb.2019.0544">10.1098/rstb.2019.0544</a>.'
  short: 'H. Shang, J. Hess, M. Pickup, D. Field, P.K. Ingvarsson, J. Liu, C. Lexer,
    Philosophical Transactions of the Royal Society. Series B: Biological Sciences
    375 (2020).'
date_created: 2020-07-26T22:01:02Z
date_published: 2020-07-12T00:00:00Z
date_updated: 2023-08-22T08:23:24Z
day: '12'
department:
- _id: NiBa
doi: 10.1098/rstb.2019.0544
external_id:
  isi:
  - '000552662100013'
  pmid:
  - '32654641'
intvolume: '       375'
isi: 1
issue: '1806'
language:
- iso: eng
month: '07'
oa_version: Published Version
pmid: 1
publication: 'Philosophical Transactions of the Royal Society. Series B: Biological
  Sciences'
publication_identifier:
  eissn:
  - '14712970'
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Evolution of strong reproductive isolation in plants: Broad-scale patterns
  and lessons from a perennial model group'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 375
year: '2020'
...
---
_id: '8170'
abstract:
- lang: eng
  text: "Alignment of OCS, CS2, and I2 molecules embedded in helium nanodroplets is
    measured as a function\r\nof time following rotational excitation by a nonresonant,
    comparatively weak ps laser pulse. The distinct\r\npeaks in the power spectra,
    obtained by Fourier analysis, are used to determine the rotational, B, and\r\ncentrifugal
    distortion, D, constants. For OCS, B and D match the values known from IR spectroscopy.
    For\r\nCS2 and I2, they are the first experimental results reported. The alignment
    dynamics calculated from the\r\ngas-phase rotational Schrödinger equation, using
    the experimental in-droplet B and D values, agree in\r\ndetail with the measurement
    for all three molecules. The rotational spectroscopy technique for molecules in\r\nhelium
    droplets introduced here should apply to a range of molecules and complexes."
acknowledgement: "H. S. acknowledges support from the European Research Council-AdG
  (Project No. 320459, DropletControl)\r\nand from The Villum Foundation through a
  Villum Investigator Grant No. 25886. M. L. acknowledges support\r\nby the Austrian
  Science Fund (FWF), under Project No. P29902-N27, and by the European Research Council\r\n(ERC)
  Starting Grant No. 801770 (ANGULON). G. B. acknowledges support from the Austrian
  Science Fund\r\n(FWF), under Project No. M2641-N27. I. C. acknowledges support by
  the European Union’s Horizon 2020 research and\r\ninnovation programme under the
  Marie Skłodowska-Curie Grant Agreement No. 665385. Computational resources for\r\nthe
  PIMC simulations were provided by the division for scientific computing at the Johannes
  Kepler University."
article_number: '013001'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Adam S.
  full_name: Chatterley, Adam S.
  last_name: Chatterley
- first_name: Lars
  full_name: Christiansen, Lars
  last_name: Christiansen
- first_name: Constant A.
  full_name: Schouder, Constant A.
  last_name: Schouder
- first_name: Anders V.
  full_name: Jørgensen, Anders V.
  last_name: Jørgensen
- first_name: Benjamin
  full_name: Shepperson, Benjamin
  last_name: Shepperson
- first_name: Igor
  full_name: Cherepanov, Igor
  id: 339C7E5A-F248-11E8-B48F-1D18A9856A87
  last_name: Cherepanov
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Robert E.
  full_name: Zillich, Robert E.
  last_name: Zillich
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Henrik
  full_name: Stapelfeldt, Henrik
  last_name: Stapelfeldt
citation:
  ama: 'Chatterley AS, Christiansen L, Schouder CA, et al. Rotational coherence spectroscopy
    of molecules in Helium nanodroplets: Reconciling the time and the frequency domains.
    <i>Physical Review Letters</i>. 2020;125(1). doi:<a href="https://doi.org/10.1103/PhysRevLett.125.013001">10.1103/PhysRevLett.125.013001</a>'
  apa: 'Chatterley, A. S., Christiansen, L., Schouder, C. A., Jørgensen, A. V., Shepperson,
    B., Cherepanov, I., … Stapelfeldt, H. (2020). Rotational coherence spectroscopy
    of molecules in Helium nanodroplets: Reconciling the time and the frequency domains.
    <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.125.013001">https://doi.org/10.1103/PhysRevLett.125.013001</a>'
  chicago: 'Chatterley, Adam S., Lars Christiansen, Constant A. Schouder, Anders V.
    Jørgensen, Benjamin Shepperson, Igor Cherepanov, Giacomo Bighin, Robert E. Zillich,
    Mikhail Lemeshko, and Henrik Stapelfeldt. “Rotational Coherence Spectroscopy of
    Molecules in Helium Nanodroplets: Reconciling the Time and the Frequency Domains.”
    <i>Physical Review Letters</i>. American Physical Society, 2020. <a href="https://doi.org/10.1103/PhysRevLett.125.013001">https://doi.org/10.1103/PhysRevLett.125.013001</a>.'
  ieee: 'A. S. Chatterley <i>et al.</i>, “Rotational coherence spectroscopy of molecules
    in Helium nanodroplets: Reconciling the time and the frequency domains,” <i>Physical
    Review Letters</i>, vol. 125, no. 1. American Physical Society, 2020.'
  ista: 'Chatterley AS, Christiansen L, Schouder CA, Jørgensen AV, Shepperson B, Cherepanov
    I, Bighin G, Zillich RE, Lemeshko M, Stapelfeldt H. 2020. Rotational coherence
    spectroscopy of molecules in Helium nanodroplets: Reconciling the time and the
    frequency domains. Physical Review Letters. 125(1), 013001.'
  mla: 'Chatterley, Adam S., et al. “Rotational Coherence Spectroscopy of Molecules
    in Helium Nanodroplets: Reconciling the Time and the Frequency Domains.” <i>Physical
    Review Letters</i>, vol. 125, no. 1, 013001, American Physical Society, 2020,
    doi:<a href="https://doi.org/10.1103/PhysRevLett.125.013001">10.1103/PhysRevLett.125.013001</a>.'
  short: A.S. Chatterley, L. Christiansen, C.A. Schouder, A.V. Jørgensen, B. Shepperson,
    I. Cherepanov, G. Bighin, R.E. Zillich, M. Lemeshko, H. Stapelfeldt, Physical
    Review Letters 125 (2020).
date_created: 2020-07-26T22:01:02Z
date_published: 2020-07-03T00:00:00Z
date_updated: 2024-08-07T07:16:52Z
day: '03'
department:
- _id: MiLe
doi: 10.1103/PhysRevLett.125.013001
ec_funded: 1
external_id:
  arxiv:
  - '2006.02694'
  isi:
  - '000544526900006'
intvolume: '       125'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2006.02694
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29902
  name: Quantum rotations in the presence of a many-body environment
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 26986C82-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02641
  name: A path-integral approach to composite impurities
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Physical Review Letters
publication_identifier:
  eissn:
  - '10797114'
  issn:
  - '00319007'
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Rotational coherence spectroscopy of molecules in Helium nanodroplets: Reconciling
  the time and the frequency domains'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 125
year: '2020'
...
---
_id: '8173'
abstract:
- lang: eng
  text: Understanding how the activity of membrane receptors and cellular signaling
    pathways shapes cell behavior is of fundamental interest in basic and applied
    research. Reengineering receptors to react to light instead of their cognate ligands
    allows for generating defined signaling inputs with high spatial and temporal
    precision and facilitates the dissection of complex signaling networks. Here,
    we describe fundamental considerations in the design of light-regulated receptor
    tyrosine kinases (Opto-RTKs) and appropriate control experiments. We also introduce
    methods for transient receptor expression in HEK293 cells, quantitative assessment
    of signaling activity in reporter gene assays, semiquantitative assessment of
    (in)activation time courses through Western blot (WB) analysis, and easy to implement
    light stimulation hardware.
alternative_title:
- Methods in Molecular Biology
article_processing_charge: No
author:
- first_name: Stephanie
  full_name: Kainrath, Stephanie
  id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
  last_name: Kainrath
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
citation:
  ama: 'Kainrath S, Janovjak HL. Design and application of light-regulated receptor
    tyrosine kinases. In: Niopek D, ed. <i>Photoswitching Proteins</i>. Vol 2173.
    MIMB. Springer Nature; 2020:233-246. doi:<a href="https://doi.org/10.1007/978-1-0716-0755-8_16">10.1007/978-1-0716-0755-8_16</a>'
  apa: Kainrath, S., &#38; Janovjak, H. L. (2020). Design and application of light-regulated
    receptor tyrosine kinases. In D. Niopek (Ed.), <i>Photoswitching Proteins</i>
    (Vol. 2173, pp. 233–246). Springer Nature. <a href="https://doi.org/10.1007/978-1-0716-0755-8_16">https://doi.org/10.1007/978-1-0716-0755-8_16</a>
  chicago: Kainrath, Stephanie, and Harald L Janovjak. “Design and Application of
    Light-Regulated Receptor Tyrosine Kinases.” In <i>Photoswitching Proteins</i>,
    edited by Dominik Niopek, 2173:233–46. MIMB. Springer Nature, 2020. <a href="https://doi.org/10.1007/978-1-0716-0755-8_16">https://doi.org/10.1007/978-1-0716-0755-8_16</a>.
  ieee: S. Kainrath and H. L. Janovjak, “Design and application of light-regulated
    receptor tyrosine kinases,” in <i>Photoswitching Proteins</i>, vol. 2173, D. Niopek,
    Ed. Springer Nature, 2020, pp. 233–246.
  ista: 'Kainrath S, Janovjak HL. 2020.Design and application of light-regulated receptor
    tyrosine kinases. In: Photoswitching Proteins. Methods in Molecular Biology, vol.
    2173, 233–246.'
  mla: Kainrath, Stephanie, and Harald L. Janovjak. “Design and Application of Light-Regulated
    Receptor Tyrosine Kinases.” <i>Photoswitching Proteins</i>, edited by Dominik
    Niopek, vol. 2173, Springer Nature, 2020, pp. 233–46, doi:<a href="https://doi.org/10.1007/978-1-0716-0755-8_16">10.1007/978-1-0716-0755-8_16</a>.
  short: S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins,
    Springer Nature, 2020, pp. 233–246.
date_created: 2020-07-26T22:01:03Z
date_published: 2020-07-11T00:00:00Z
date_updated: 2021-01-12T08:17:17Z
day: '11'
department:
- _id: CaGu
doi: 10.1007/978-1-0716-0755-8_16
editor:
- first_name: Dominik
  full_name: Niopek, Dominik
  last_name: Niopek
intvolume: '      2173'
language:
- iso: eng
month: '07'
oa_version: None
page: 233-246
publication: Photoswitching Proteins
publication_identifier:
  eisbn:
  - '9781071607558'
  eissn:
  - '19406029'
publication_status: published
publisher: Springer Nature
scopus_import: '1'
series_title: MIMB
status: public
title: Design and application of light-regulated receptor tyrosine kinases
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2173
year: '2020'
...
---
_id: '8181'
author:
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
citation:
  ama: Hauschild R. Amplified centrosomes in dendritic cells promote immune cell effector
    functions. 2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:8181">10.15479/AT:ISTA:8181</a>
  apa: Hauschild, R. (2020). Amplified centrosomes in dendritic cells promote immune
    cell effector functions. IST Austria. <a href="https://doi.org/10.15479/AT:ISTA:8181">https://doi.org/10.15479/AT:ISTA:8181</a>
  chicago: Hauschild, Robert. “Amplified Centrosomes in Dendritic Cells Promote Immune
    Cell Effector Functions.” IST Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:8181">https://doi.org/10.15479/AT:ISTA:8181</a>.
  ieee: R. Hauschild, “Amplified centrosomes in dendritic cells promote immune cell
    effector functions.” IST Austria, 2020.
  ista: Hauschild R. 2020. Amplified centrosomes in dendritic cells promote immune
    cell effector functions, IST Austria, <a href="https://doi.org/10.15479/AT:ISTA:8181">10.15479/AT:ISTA:8181</a>.
  mla: Hauschild, Robert. <i>Amplified Centrosomes in Dendritic Cells Promote Immune
    Cell Effector Functions</i>. IST Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:8181">10.15479/AT:ISTA:8181</a>.
  short: R. Hauschild, (2020).
date_created: 2020-07-28T16:24:37Z
date_published: 2020-08-24T00:00:00Z
date_updated: 2021-01-11T15:29:08Z
day: '24'
department:
- _id: Bio
doi: 10.15479/AT:ISTA:8181
file:
- access_level: open_access
  checksum: 878c60885ce30afb59a884dd5eef451c
  content_type: text/plain
  creator: rhauschild
  date_created: 2020-08-24T15:43:49Z
  date_updated: 2020-08-24T15:43:49Z
  file_id: '8290'
  file_name: centriolesDistance.m
  file_size: 6577
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 5a93ac7be2b66b28e4bd8b113ee6aade
  content_type: text/plain
  creator: rhauschild
  date_created: 2020-08-24T15:43:52Z
  date_updated: 2020-08-24T15:43:52Z
  file_id: '8291'
  file_name: goTracking.m
  file_size: 2680
  relation: main_file
  success: 1
file_date_updated: 2020-08-24T15:43:52Z
has_accepted_license: '1'
license: https://opensource.org/licenses/BSD-3-Clause
month: '08'
oa: 1
publisher: IST Austria
status: public
title: Amplified centrosomes in dendritic cells promote immune cell effector functions
tmp:
  legal_code_url: https://opensource.org/licenses/BSD-3-Clause
  name: The 3-Clause BSD License
  short: 3-Clause BSD
type: software
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8186'
abstract:
- lang: eng
  text: "Numerous methods have been proposed for probabilistic generative modelling
    of\r\n3D objects. However, none of these is able to produce textured objects,
    which\r\nrenders them of limited use for practical tasks. In this work, we present
    the\r\nfirst generative model of textured 3D meshes. Training such a model would\r\ntraditionally
    require a large dataset of textured meshes, but unfortunately,\r\nexisting datasets
    of meshes lack detailed textures. We instead propose a new\r\ntraining methodology
    that allows learning from collections of 2D images without\r\nany 3D information.
    To do so, we train our model to explain a distribution of\r\nimages by modelling
    each image as a 3D foreground object placed in front of a\r\n2D background. Thus,
    it learns to generate meshes that when rendered, produce\r\nimages similar to
    those in its training set.\r\n  A well-known problem when generating meshes with
    deep networks is the\r\nemergence of self-intersections, which are problematic
    for many use-cases. As a\r\nsecond contribution we therefore introduce a new generation
    process for 3D\r\nmeshes that guarantees no self-intersections arise, based on
    the physical\r\nintuition that faces should push one another out of the way as
    they move.\r\n  We conduct extensive experiments on our approach, reporting quantitative
    and\r\nqualitative results on both synthetic data and natural images. These show
    our\r\nmethod successfully learns to generate plausible and diverse textured 3D\r\nsamples
    for five challenging object classes."
article_processing_charge: No
arxiv: 1
author:
- first_name: Paul M
  full_name: Henderson, Paul M
  id: 13C09E74-18D9-11E9-8878-32CFE5697425
  last_name: Henderson
  orcid: 0000-0002-5198-7445
- first_name: Vagia
  full_name: Tsiminaki, Vagia
  last_name: Tsiminaki
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: 'Henderson PM, Tsiminaki V, Lampert C. Leveraging 2D data to learn textured
    3D mesh generation. In: <i>Proceedings of the IEEE/CVF Conference on Computer
    Vision and Pattern Recognition</i>. IEEE; 2020:7498-7507. doi:<a href="https://doi.org/10.1109/CVPR42600.2020.00752">10.1109/CVPR42600.2020.00752</a>'
  apa: 'Henderson, P. M., Tsiminaki, V., &#38; Lampert, C. (2020). Leveraging 2D data
    to learn textured 3D mesh generation. In <i>Proceedings of the IEEE/CVF Conference
    on Computer Vision and Pattern Recognition</i> (pp. 7498–7507). Virtual: IEEE.
    <a href="https://doi.org/10.1109/CVPR42600.2020.00752">https://doi.org/10.1109/CVPR42600.2020.00752</a>'
  chicago: Henderson, Paul M, Vagia Tsiminaki, and Christoph Lampert. “Leveraging
    2D Data to Learn Textured 3D Mesh Generation.” In <i>Proceedings of the IEEE/CVF
    Conference on Computer Vision and Pattern Recognition</i>, 7498–7507. IEEE, 2020.
    <a href="https://doi.org/10.1109/CVPR42600.2020.00752">https://doi.org/10.1109/CVPR42600.2020.00752</a>.
  ieee: P. M. Henderson, V. Tsiminaki, and C. Lampert, “Leveraging 2D data to learn
    textured 3D mesh generation,” in <i>Proceedings of the IEEE/CVF Conference on
    Computer Vision and Pattern Recognition</i>, Virtual, 2020, pp. 7498–7507.
  ista: 'Henderson PM, Tsiminaki V, Lampert C. 2020. Leveraging 2D data to learn textured
    3D mesh generation. Proceedings of the IEEE/CVF Conference on Computer Vision
    and Pattern Recognition. CVPR: Conference on Computer Vision and Pattern Recognition,
    7498–7507.'
  mla: Henderson, Paul M., et al. “Leveraging 2D Data to Learn Textured 3D Mesh Generation.”
    <i>Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition</i>,
    IEEE, 2020, pp. 7498–507, doi:<a href="https://doi.org/10.1109/CVPR42600.2020.00752">10.1109/CVPR42600.2020.00752</a>.
  short: P.M. Henderson, V. Tsiminaki, C. Lampert, in:, Proceedings of the IEEE/CVF
    Conference on Computer Vision and Pattern Recognition, IEEE, 2020, pp. 7498–7507.
conference:
  end_date: 2020-06-19
  location: Virtual
  name: 'CVPR: Conference on Computer Vision and Pattern Recognition'
  start_date: 2020-06-14
date_created: 2020-07-31T16:53:49Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2023-10-17T07:37:11Z
day: '01'
ddc:
- '004'
department:
- _id: ChLa
doi: 10.1109/CVPR42600.2020.00752
external_id:
  arxiv:
  - '2004.04180'
file:
- access_level: open_access
  content_type: application/pdf
  creator: phenders
  date_created: 2020-07-31T16:57:12Z
  date_updated: 2020-07-31T16:57:12Z
  file_id: '8187'
  file_name: paper.pdf
  file_size: 10262773
  relation: main_file
  success: 1
file_date_updated: 2020-07-31T16:57:12Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://openaccess.thecvf.com/content_CVPR_2020/papers/Henderson_Leveraging_2D_Data_to_Learn_Textured_3D_Mesh_Generation_CVPR_2020_paper.pdf
month: '07'
oa: 1
oa_version: Submitted Version
page: 7498-7507
publication: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern
  Recognition
publication_identifier:
  eisbn:
  - '9781728171685'
  eissn:
  - 2575-7075
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Leveraging 2D data to learn textured 3D mesh generation
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8188'
abstract:
- lang: eng
  text: "A natural approach to generative modeling of videos is to represent them
    as a composition of moving objects. Recent works model a set of 2D sprites over
    a slowly-varying background, but without considering the underlying 3D scene that\r\ngives
    rise to them. We instead propose to model a video as the view seen while moving
    through a scene with multiple 3D objects and a 3D background. Our model is trained
    from monocular videos without any supervision, yet learns to\r\ngenerate coherent
    3D scenes containing several moving objects. We conduct detailed experiments on
    two datasets, going beyond the visual complexity supported by state-of-the-art
    generative approaches. We evaluate our method on\r\ndepth-prediction and 3D object
    detection---tasks which cannot be addressed by those earlier works---and show
    it out-performs them even on 2D instance segmentation and tracking."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "This research was supported by the Scientific Service Units (SSU)
  of IST Austria through resources\r\nprovided by Scientific Computing (SciComp).
  PH is employed part-time by Blackford Analysis, but\r\nthey did not support this
  project in any way."
article_processing_charge: No
arxiv: 1
author:
- first_name: Paul M
  full_name: Henderson, Paul M
  id: 13C09E74-18D9-11E9-8878-32CFE5697425
  last_name: Henderson
  orcid: 0000-0002-5198-7445
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: 'Henderson PM, Lampert C. Unsupervised object-centric video generation and
    decomposition in 3D. In: <i>34th Conference on Neural Information Processing Systems</i>.
    Vol 33. Curran Associates; 2020:3106–3117.'
  apa: 'Henderson, P. M., &#38; Lampert, C. (2020). Unsupervised object-centric video
    generation and decomposition in 3D. In <i>34th Conference on Neural Information
    Processing Systems</i> (Vol. 33, pp. 3106–3117). Vancouver, Canada: Curran Associates.'
  chicago: Henderson, Paul M, and Christoph Lampert. “Unsupervised Object-Centric
    Video Generation and Decomposition in 3D.” In <i>34th Conference on Neural Information
    Processing Systems</i>, 33:3106–3117. Curran Associates, 2020.
  ieee: P. M. Henderson and C. Lampert, “Unsupervised object-centric video generation
    and decomposition in 3D,” in <i>34th Conference on Neural Information Processing
    Systems</i>, Vancouver, Canada, 2020, vol. 33, pp. 3106–3117.
  ista: 'Henderson PM, Lampert C. 2020. Unsupervised object-centric video generation
    and decomposition in 3D. 34th Conference on Neural Information Processing Systems.
    NeurIPS: Neural Information Processing Systems vol. 33, 3106–3117.'
  mla: Henderson, Paul M., and Christoph Lampert. “Unsupervised Object-Centric Video
    Generation and Decomposition in 3D.” <i>34th Conference on Neural Information
    Processing Systems</i>, vol. 33, Curran Associates, 2020, pp. 3106–3117.
  short: P.M. Henderson, C. Lampert, in:, 34th Conference on Neural Information Processing
    Systems, Curran Associates, 2020, pp. 3106–3117.
conference:
  end_date: 2020-12-12
  location: Vancouver, Canada
  name: 'NeurIPS: Neural Information Processing Systems'
  start_date: 2020-12-06
date_created: 2020-07-31T16:59:19Z
date_published: 2020-07-07T00:00:00Z
date_updated: 2023-04-25T09:49:58Z
day: '07'
department:
- _id: ChLa
external_id:
  arxiv:
  - '2007.06705'
intvolume: '        33'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2007.06705
month: '07'
oa: 1
oa_version: Preprint
page: 3106–3117
publication: 34th Conference on Neural Information Processing Systems
publication_identifier:
  isbn:
  - '9781713829546'
publication_status: published
publisher: Curran Associates
quality_controlled: '1'
status: public
title: Unsupervised object-centric video generation and decomposition in 3D
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '8189'
abstract:
- lang: eng
  text: Direct ethanol fuel cells (DEFCs) show a huge potential to power future electric
    vehicles and portable electronics, but their deployment is currently limited by
    the unavailability of proper electrocatalysis for the ethanol oxidation reaction
    (EOR). In this work, we engineer a new electrocatalyst by incorporating phosphorous
    into a palladium-tin alloy and demonstrate a significant performance improvement
    toward EOR. We first detail a synthetic method to produce Pd2Sn:P nanocrystals
    that incorporate 35% of phosphorus. These nanoparticles are supported on carbon
    black and tested for EOR. Pd2Sn:P/C catalysts exhibit mass current densities up
    to 5.03 A mgPd−1, well above those of Pd2Sn/C, PdP2/C and Pd/C reference catalysts.
    Furthermore, a twofold lower Tafel slope and a much longer durability are revealed
    for the Pd2Sn:P/C catalyst compared with Pd/C. The performance improvement is
    rationalized with the aid of density functional theory (DFT) calculations considering
    different phosphorous chemical environments. Depending on its oxidation state,
    surface phosphorus introduces sites with low energy OH− adsorption and/or strongly
    influences the electronic structure of palladium and tin to facilitate the oxidation
    of the acetyl to acetic acid, which is considered the EOR rate limiting step.
    DFT calculations also points out that the durability improvement of Pd2Sn:P/C
    catalyst is associated to the promotion of OH adsorption that accelerates the
    oxidation of intermediate poisoning COads, reactivating the catalyst surface.
acknowledgement: This work was supported by the European Regional Development Funds
  and by the Spanish Ministerio de Economía y Competitividad through the project SEHTOP,
  ENE2016- 77798-C4-3-R, and ENE2017-85087-C3. X. Y. thanks the China Scholarship
  Council for the scholarship support. J. Liu acknowledges support from the Jiangsu
  University Foundation (4111510011). J. Li obtained International Postdoctoral Exchange
  Fellowship Program (Talent-Introduction program) in 2019 and is grateful for the
  project (2019M663468) funded by the China Postdoctoral Science Foundation. Authors
  acknowledge funding from Generalitat de Catalunya 2017 SGR 327 and 2017 SGR 1246,
  and from IST Austria. ICN2 acknowledges the support from the Severo Ochoa Programme
  (MINECO, grant no. SEV-2017-0706) and is funded by the CERCA Programme/Generalitat
  de Catalunya. J. Llorca is a Serra Húnter Fellow and is grateful to MICINN/FEDER
  RTI2018-093996-B-C31, GC 2017 SGR 128 and to ICREA Academia program.
article_number: '105116'
article_processing_charge: No
article_type: original
author:
- first_name: Xiaoting
  full_name: Yu, Xiaoting
  last_name: Yu
- first_name: Junfeng
  full_name: Liu, Junfeng
  last_name: Liu
- first_name: Junshan
  full_name: Li, Junshan
  last_name: Li
- first_name: Zhishan
  full_name: Luo, Zhishan
  last_name: Luo
- first_name: Yong
  full_name: Zuo, Yong
  last_name: Zuo
- first_name: Congcong
  full_name: Xing, Congcong
  last_name: Xing
- first_name: Jordi
  full_name: Llorca, Jordi
  last_name: Llorca
- first_name: Déspina
  full_name: Nasiou, Déspina
  last_name: Nasiou
- first_name: Jordi
  full_name: Arbiol, Jordi
  last_name: Arbiol
- first_name: Kai
  full_name: Pan, Kai
  last_name: Pan
- first_name: Tobias
  full_name: Kleinhanns, Tobias
  id: 8BD9DE16-AB3C-11E9-9C8C-2A03E6697425
  last_name: Kleinhanns
- first_name: Ying
  full_name: Xie, Ying
  last_name: Xie
- first_name: Andreu
  full_name: Cabot, Andreu
  last_name: Cabot
citation:
  ama: Yu X, Liu J, Li J, et al. Phosphorous incorporation in Pd2Sn alloys for electrocatalytic
    ethanol oxidation. <i>Nano Energy</i>. 2020;77(11). doi:<a href="https://doi.org/10.1016/j.nanoen.2020.105116">10.1016/j.nanoen.2020.105116</a>
  apa: Yu, X., Liu, J., Li, J., Luo, Z., Zuo, Y., Xing, C., … Cabot, A. (2020). Phosphorous
    incorporation in Pd2Sn alloys for electrocatalytic ethanol oxidation. <i>Nano
    Energy</i>. Elsevier. <a href="https://doi.org/10.1016/j.nanoen.2020.105116">https://doi.org/10.1016/j.nanoen.2020.105116</a>
  chicago: Yu, Xiaoting, Junfeng Liu, Junshan Li, Zhishan Luo, Yong Zuo, Congcong
    Xing, Jordi Llorca, et al. “Phosphorous Incorporation in Pd2Sn Alloys for Electrocatalytic
    Ethanol Oxidation.” <i>Nano Energy</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.nanoen.2020.105116">https://doi.org/10.1016/j.nanoen.2020.105116</a>.
  ieee: X. Yu <i>et al.</i>, “Phosphorous incorporation in Pd2Sn alloys for electrocatalytic
    ethanol oxidation,” <i>Nano Energy</i>, vol. 77, no. 11. Elsevier, 2020.
  ista: Yu X, Liu J, Li J, Luo Z, Zuo Y, Xing C, Llorca J, Nasiou D, Arbiol J, Pan
    K, Kleinhanns T, Xie Y, Cabot A. 2020. Phosphorous incorporation in Pd2Sn alloys
    for electrocatalytic ethanol oxidation. Nano Energy. 77(11), 105116.
  mla: Yu, Xiaoting, et al. “Phosphorous Incorporation in Pd2Sn Alloys for Electrocatalytic
    Ethanol Oxidation.” <i>Nano Energy</i>, vol. 77, no. 11, 105116, Elsevier, 2020,
    doi:<a href="https://doi.org/10.1016/j.nanoen.2020.105116">10.1016/j.nanoen.2020.105116</a>.
  short: X. Yu, J. Liu, J. Li, Z. Luo, Y. Zuo, C. Xing, J. Llorca, D. Nasiou, J. Arbiol,
    K. Pan, T. Kleinhanns, Y. Xie, A. Cabot, Nano Energy 77 (2020).
date_created: 2020-08-02T22:00:57Z
date_published: 2020-11-01T00:00:00Z
date_updated: 2023-08-22T08:24:05Z
day: '01'
department:
- _id: MaIb
doi: 10.1016/j.nanoen.2020.105116
external_id:
  isi:
  - '000581738300030'
intvolume: '        77'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
publication: Nano Energy
publication_identifier:
  issn:
  - 2211-2855
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phosphorous incorporation in Pd2Sn alloys for electrocatalytic ethanol oxidation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 77
year: '2020'
...
---
_id: '8190'
article_number: e202007029
article_processing_charge: No
article_type: letter_note
author:
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Anna
  full_name: Huttenlocher, Anna
  last_name: Huttenlocher
citation:
  ama: 'Sixt MK, Huttenlocher A. Zena Werb (1945-2020): Cell biology in context. <i>The
    Journal of Cell Biology</i>. 2020;219(8). doi:<a href="https://doi.org/10.1083/jcb.202007029">10.1083/jcb.202007029</a>'
  apa: 'Sixt, M. K., &#38; Huttenlocher, A. (2020). Zena Werb (1945-2020): Cell biology
    in context. <i>The Journal of Cell Biology</i>. Rockefeller University Press.
    <a href="https://doi.org/10.1083/jcb.202007029">https://doi.org/10.1083/jcb.202007029</a>'
  chicago: 'Sixt, Michael K, and Anna Huttenlocher. “Zena Werb (1945-2020): Cell Biology
    in Context.” <i>The Journal of Cell Biology</i>. Rockefeller University Press,
    2020. <a href="https://doi.org/10.1083/jcb.202007029">https://doi.org/10.1083/jcb.202007029</a>.'
  ieee: 'M. K. Sixt and A. Huttenlocher, “Zena Werb (1945-2020): Cell biology in context,”
    <i>The Journal of Cell Biology</i>, vol. 219, no. 8. Rockefeller University Press,
    2020.'
  ista: 'Sixt MK, Huttenlocher A. 2020. Zena Werb (1945-2020): Cell biology in context.
    The Journal of Cell Biology. 219(8), e202007029.'
  mla: 'Sixt, Michael K., and Anna Huttenlocher. “Zena Werb (1945-2020): Cell Biology
    in Context.” <i>The Journal of Cell Biology</i>, vol. 219, no. 8, e202007029,
    Rockefeller University Press, 2020, doi:<a href="https://doi.org/10.1083/jcb.202007029">10.1083/jcb.202007029</a>.'
  short: M.K. Sixt, A. Huttenlocher, The Journal of Cell Biology 219 (2020).
date_created: 2020-08-02T22:00:57Z
date_published: 2020-07-22T00:00:00Z
date_updated: 2023-10-17T10:04:49Z
day: '22'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1083/jcb.202007029
external_id:
  isi:
  - '000573631000004'
file:
- access_level: open_access
  checksum: 30016d778d266b8e17d01094917873b8
  content_type: application/pdf
  creator: dernst
  date_created: 2020-08-04T13:11:52Z
  date_updated: 2021-02-02T23:30:03Z
  embargo: 2021-02-01
  file_id: '8200'
  file_name: 2020_JCB_Sixt.pdf
  file_size: 830725
  relation: main_file
file_date_updated: 2021-02-02T23:30:03Z
has_accepted_license: '1'
intvolume: '       219'
isi: 1
issue: '8'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '07'
oa: 1
oa_version: Published Version
publication: The Journal of Cell Biology
publication_identifier:
  eissn:
  - 1540-8140
publication_status: published
publisher: Rockefeller University Press
scopus_import: '1'
status: public
title: 'Zena Werb (1945-2020): Cell biology in context'
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 219
year: '2020'
...
---
_id: '8191'
abstract:
- lang: eng
  text: "There has been a significant amount of research on hardware and software
    support for efficient concurrent data structures; yet, the question of how to
    build correct, simple, and scalable data structures has not yet been definitively
    settled. In this paper, we revisit this question from a minimalist perspective,
    and ask: what is the smallest amount of synchronization required for correct and
    efficient concurrent search data structures, and how could this minimal synchronization
    support be provided in hardware?\r\n\r\nTo address these questions, we introduce
    memory tagging, a simple hardware mechanism which enables the programmer to \"tag\"
    a dynamic set of memory locations, at cache-line granularity, and later validate
    whether the memory has been concurrently modified, with the possibility of updating
    one of the underlying locations atomically if validation succeeds. We provide
    several examples showing that this mechanism can enable fast and arguably simple
    concurrent data structure designs, such as lists, binary search trees, balanced
    search trees, range queries, and Software Transactional Memory (STM) implementations.
    We provide an implementation of memory tags in the Graphite multi-core simulator,
    showing that the mechanism can be implemented entirely at the level of L1 cache,
    and that it can enable non-trivial speedups versus existing implementations of
    the above data structures."
article_processing_charge: No
author:
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Trevor A
  full_name: Brown, Trevor A
  id: 3569F0A0-F248-11E8-B48F-1D18A9856A87
  last_name: Brown
- first_name: Nandini
  full_name: Singhal, Nandini
  last_name: Singhal
citation:
  ama: 'Alistarh D-A, Brown TA, Singhal N. Memory tagging: Minimalist synchronization
    for scalable concurrent data structures. In: <i>Annual ACM Symposium on Parallelism
    in Algorithms and Architectures</i>. Association for Computing Machinery; 2020:37-49.
    doi:<a href="https://doi.org/10.1145/3350755.3400213">10.1145/3350755.3400213</a>'
  apa: 'Alistarh, D.-A., Brown, T. A., &#38; Singhal, N. (2020). Memory tagging: Minimalist
    synchronization for scalable concurrent data structures. In <i>Annual ACM Symposium
    on Parallelism in Algorithms and Architectures</i> (pp. 37–49). Virtual Event,
    United States: Association for Computing Machinery. <a href="https://doi.org/10.1145/3350755.3400213">https://doi.org/10.1145/3350755.3400213</a>'
  chicago: 'Alistarh, Dan-Adrian, Trevor A Brown, and Nandini Singhal. “Memory Tagging:
    Minimalist Synchronization for Scalable Concurrent Data Structures.” In <i>Annual
    ACM Symposium on Parallelism in Algorithms and Architectures</i>, 37–49. Association
    for Computing Machinery, 2020. <a href="https://doi.org/10.1145/3350755.3400213">https://doi.org/10.1145/3350755.3400213</a>.'
  ieee: 'D.-A. Alistarh, T. A. Brown, and N. Singhal, “Memory tagging: Minimalist
    synchronization for scalable concurrent data structures,” in <i>Annual ACM Symposium
    on Parallelism in Algorithms and Architectures</i>, Virtual Event, United States,
    2020, no. 7, pp. 37–49.'
  ista: 'Alistarh D-A, Brown TA, Singhal N. 2020. Memory tagging: Minimalist synchronization
    for scalable concurrent data structures. Annual ACM Symposium on Parallelism in
    Algorithms and Architectures. SPAA: Symposium on Parallelism in Algorithms and
    Architectures, 37–49.'
  mla: 'Alistarh, Dan-Adrian, et al. “Memory Tagging: Minimalist Synchronization for
    Scalable Concurrent Data Structures.” <i>Annual ACM Symposium on Parallelism in
    Algorithms and Architectures</i>, no. 7, Association for Computing Machinery,
    2020, pp. 37–49, doi:<a href="https://doi.org/10.1145/3350755.3400213">10.1145/3350755.3400213</a>.'
  short: D.-A. Alistarh, T.A. Brown, N. Singhal, in:, Annual ACM Symposium on Parallelism
    in Algorithms and Architectures, Association for Computing Machinery, 2020, pp.
    37–49.
conference:
  end_date: 2020-07-17
  location: Virtual Event, United States
  name: 'SPAA: Symposium on Parallelism in Algorithms and Architectures'
  start_date: 2020-07-15
date_created: 2020-08-02T22:00:58Z
date_published: 2020-07-06T00:00:00Z
date_updated: 2024-02-28T12:56:32Z
day: '06'
department:
- _id: DaAl
doi: 10.1145/3350755.3400213
external_id:
  isi:
  - '000744436200004'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 37-49
publication: Annual ACM Symposium on Parallelism in Algorithms and Architectures
publication_identifier:
  isbn:
  - '9781450369350'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Memory tagging: Minimalist synchronization for scalable concurrent data structures'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8193'
abstract:
- lang: eng
  text: 'Multiple-environment Markov decision processes (MEMDPs) are MDPs equipped
    with not one, but multiple probabilistic transition functions, which represent
    the various possible unknown environments. While the previous research on MEMDPs
    focused on theoretical properties for long-run average payoff, we study them with
    discounted-sum payoff and focus on their practical advantages and applications.
    MEMDPs can be viewed as a special case of Partially observable and Mixed observability
    MDPs: the state of the system is perfectly observable, but not the environment.
    We show that the specific structure of MEMDPs allows for more efficient algorithmic
    analysis, in particular for faster belief updates. We demonstrate the applicability
    of MEMDPs in several domains. In particular, we formalize the sequential decision-making
    approach to contextual recommendation systems as MEMDPs and substantially improve
    over the previous MDP approach.'
acknowledgement: Krishnendu Chatterjee is supported by the Austrian ScienceFund (FWF)
  NFN Grant No. S11407-N23 (RiSE/SHiNE),and COST Action GAMENET. Petr Novotn ́y is
  supported bythe Czech Science Foundation grant No. GJ19-15134Y.
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Chmelik, Martin
  id: 3624234E-F248-11E8-B48F-1D18A9856A87
  last_name: Chmelik
- first_name: Deep
  full_name: Karkhanis, Deep
  last_name: Karkhanis
- first_name: Petr
  full_name: Novotný, Petr
  id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
  last_name: Novotný
- first_name: Amélie
  full_name: Royer, Amélie
  id: 3811D890-F248-11E8-B48F-1D18A9856A87
  last_name: Royer
  orcid: 0000-0002-8407-0705
citation:
  ama: 'Chatterjee K, Chmelik M, Karkhanis D, Novotný P, Royer A. Multiple-environment
    Markov decision processes: Efficient analysis and applications. In: <i>Proceedings
    of the 30th International Conference on Automated Planning and Scheduling</i>.
    Vol 30. Association for the Advancement of Artificial Intelligence; 2020:48-56.'
  apa: 'Chatterjee, K., Chmelik, M., Karkhanis, D., Novotný, P., &#38; Royer, A. (2020).
    Multiple-environment Markov decision processes: Efficient analysis and applications.
    In <i>Proceedings of the 30th International Conference on Automated Planning and
    Scheduling</i> (Vol. 30, pp. 48–56). Nancy, France: Association for the Advancement
    of Artificial Intelligence.'
  chicago: 'Chatterjee, Krishnendu, Martin Chmelik, Deep Karkhanis, Petr Novotný,
    and Amélie Royer. “Multiple-Environment Markov Decision Processes: Efficient Analysis
    and Applications.” In <i>Proceedings of the 30th International Conference on Automated
    Planning and Scheduling</i>, 30:48–56. Association for the Advancement of Artificial
    Intelligence, 2020.'
  ieee: 'K. Chatterjee, M. Chmelik, D. Karkhanis, P. Novotný, and A. Royer, “Multiple-environment
    Markov decision processes: Efficient analysis and applications,” in <i>Proceedings
    of the 30th International Conference on Automated Planning and Scheduling</i>,
    Nancy, France, 2020, vol. 30, pp. 48–56.'
  ista: 'Chatterjee K, Chmelik M, Karkhanis D, Novotný P, Royer A. 2020. Multiple-environment
    Markov decision processes: Efficient analysis and applications. Proceedings of
    the 30th International Conference on Automated Planning and Scheduling. ICAPS:
    International Conference on Automated Planning and Scheduling vol. 30, 48–56.'
  mla: 'Chatterjee, Krishnendu, et al. “Multiple-Environment Markov Decision Processes:
    Efficient Analysis and Applications.” <i>Proceedings of the 30th International
    Conference on Automated Planning and Scheduling</i>, vol. 30, Association for
    the Advancement of Artificial Intelligence, 2020, pp. 48–56.'
  short: K. Chatterjee, M. Chmelik, D. Karkhanis, P. Novotný, A. Royer, in:, Proceedings
    of the 30th International Conference on Automated Planning and Scheduling, Association
    for the Advancement of Artificial Intelligence, 2020, pp. 48–56.
conference:
  end_date: 2020-10-30
  location: Nancy, France
  name: 'ICAPS: International Conference on Automated Planning and Scheduling'
  start_date: 2020-10-26
date_created: 2020-08-02T22:00:58Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2023-09-07T13:16:18Z
day: '01'
department:
- _id: KrCh
intvolume: '        30'
language:
- iso: eng
month: '06'
oa_version: None
page: 48-56
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
publication: Proceedings of the 30th International Conference on Automated Planning
  and Scheduling
publication_identifier:
  eissn:
  - '23340843'
  issn:
  - '23340835'
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
related_material:
  record:
  - id: '8390'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: 'Multiple-environment Markov decision processes: Efficient analysis and applications'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2020'
...
---
_id: '8194'
abstract:
- lang: eng
  text: 'Fixed-point arithmetic is a popular alternative to floating-point arithmetic
    on embedded systems. Existing work on the verification of fixed-point programs
    relies on custom formalizations of fixed-point arithmetic, which makes it hard
    to compare the described techniques or reuse the implementations. In this paper,
    we address this issue by proposing and formalizing an SMT theory of fixed-point
    arithmetic. We present an intuitive yet comprehensive syntax of the fixed-point
    theory, and provide formal semantics for it based on rational arithmetic. We also
    describe two decision procedures for this theory: one based on the theory of bit-vectors
    and the other on the theory of reals. We implement the two decision procedures,
    and evaluate our implementations using existing mature SMT solvers on a benchmark
    suite we created. Finally, we perform a case study of using the theory we propose
    to verify properties of quantized neural networks.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Marek
  full_name: Baranowski, Marek
  last_name: Baranowski
- first_name: Shaobo
  full_name: He, Shaobo
  last_name: He
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
- first_name: Thanh Son
  full_name: Nguyen, Thanh Son
  last_name: Nguyen
- first_name: Zvonimir
  full_name: Rakamarić, Zvonimir
  last_name: Rakamarić
citation:
  ama: 'Baranowski M, He S, Lechner M, Nguyen TS, Rakamarić Z. An SMT theory of fixed-point
    arithmetic. In: <i>Automated Reasoning</i>. Vol 12166. Springer Nature; 2020:13-31.
    doi:<a href="https://doi.org/10.1007/978-3-030-51074-9_2">10.1007/978-3-030-51074-9_2</a>'
  apa: 'Baranowski, M., He, S., Lechner, M., Nguyen, T. S., &#38; Rakamarić, Z. (2020).
    An SMT theory of fixed-point arithmetic. In <i>Automated Reasoning</i> (Vol. 12166,
    pp. 13–31). Paris, France: Springer Nature. <a href="https://doi.org/10.1007/978-3-030-51074-9_2">https://doi.org/10.1007/978-3-030-51074-9_2</a>'
  chicago: Baranowski, Marek, Shaobo He, Mathias Lechner, Thanh Son Nguyen, and Zvonimir
    Rakamarić. “An SMT Theory of Fixed-Point Arithmetic.” In <i>Automated Reasoning</i>,
    12166:13–31. Springer Nature, 2020. <a href="https://doi.org/10.1007/978-3-030-51074-9_2">https://doi.org/10.1007/978-3-030-51074-9_2</a>.
  ieee: M. Baranowski, S. He, M. Lechner, T. S. Nguyen, and Z. Rakamarić, “An SMT
    theory of fixed-point arithmetic,” in <i>Automated Reasoning</i>, Paris, France,
    2020, vol. 12166, pp. 13–31.
  ista: 'Baranowski M, He S, Lechner M, Nguyen TS, Rakamarić Z. 2020. An SMT theory
    of fixed-point arithmetic. Automated Reasoning. IJCAR: International Joint Conference
    on Automated Reasoning, LNCS, vol. 12166, 13–31.'
  mla: Baranowski, Marek, et al. “An SMT Theory of Fixed-Point Arithmetic.” <i>Automated
    Reasoning</i>, vol. 12166, Springer Nature, 2020, pp. 13–31, doi:<a href="https://doi.org/10.1007/978-3-030-51074-9_2">10.1007/978-3-030-51074-9_2</a>.
  short: M. Baranowski, S. He, M. Lechner, T.S. Nguyen, Z. Rakamarić, in:, Automated
    Reasoning, Springer Nature, 2020, pp. 13–31.
conference:
  end_date: 2020-07-04
  location: Paris, France
  name: 'IJCAR: International Joint Conference on Automated Reasoning'
  start_date: 2020-07-01
date_created: 2020-08-02T22:00:59Z
date_published: 2020-06-24T00:00:00Z
date_updated: 2023-08-22T08:27:25Z
day: '24'
department:
- _id: ToHe
doi: 10.1007/978-3-030-51074-9_2
external_id:
  isi:
  - '000884318000002'
intvolume: '     12166'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/978-3-030-51074-9_2
month: '06'
oa: 1
oa_version: Published Version
page: 13-31
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: The Wittgenstein Prize
publication: Automated Reasoning
publication_identifier:
  eissn:
  - '16113349'
  isbn:
  - '9783030510732'
  issn:
  - '03029743'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: An SMT theory of fixed-point arithmetic
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12166
year: '2020'
...
---
_id: '8195'
abstract:
- lang: eng
  text: This paper presents a foundation for refining concurrent programs with structured
    control flow. The verification problem is decomposed into subproblems that aid
    interactive program development, proof reuse, and automation. The formalization
    in this paper is the basis of a new design and implementation of the Civl verifier.
acknowledgement: "Bernhard Kragl and Thomas A. Henzinger were supported by\r\nthe
  Austrian Science Fund (FWF) under grant Z211-N23 (Wittgenstein Award)."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Bernhard
  full_name: Kragl, Bernhard
  id: 320FC952-F248-11E8-B48F-1D18A9856A87
  last_name: Kragl
  orcid: 0000-0001-7745-9117
- first_name: Shaz
  full_name: Qadeer, Shaz
  last_name: Qadeer
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
citation:
  ama: 'Kragl B, Qadeer S, Henzinger TA. Refinement for structured concurrent programs.
    In: <i>Computer Aided Verification</i>. Vol 12224. Springer Nature; 2020:275-298.
    doi:<a href="https://doi.org/10.1007/978-3-030-53288-8_14">10.1007/978-3-030-53288-8_14</a>'
  apa: Kragl, B., Qadeer, S., &#38; Henzinger, T. A. (2020). Refinement for structured
    concurrent programs. In <i>Computer Aided Verification</i> (Vol. 12224, pp. 275–298).
    Springer Nature. <a href="https://doi.org/10.1007/978-3-030-53288-8_14">https://doi.org/10.1007/978-3-030-53288-8_14</a>
  chicago: Kragl, Bernhard, Shaz Qadeer, and Thomas A Henzinger. “Refinement for Structured
    Concurrent Programs.” In <i>Computer Aided Verification</i>, 12224:275–98. Springer
    Nature, 2020. <a href="https://doi.org/10.1007/978-3-030-53288-8_14">https://doi.org/10.1007/978-3-030-53288-8_14</a>.
  ieee: B. Kragl, S. Qadeer, and T. A. Henzinger, “Refinement for structured concurrent
    programs,” in <i>Computer Aided Verification</i>, 2020, vol. 12224, pp. 275–298.
  ista: Kragl B, Qadeer S, Henzinger TA. 2020. Refinement for structured concurrent
    programs. Computer Aided Verification. , LNCS, vol. 12224, 275–298.
  mla: Kragl, Bernhard, et al. “Refinement for Structured Concurrent Programs.” <i>Computer
    Aided Verification</i>, vol. 12224, Springer Nature, 2020, pp. 275–98, doi:<a
    href="https://doi.org/10.1007/978-3-030-53288-8_14">10.1007/978-3-030-53288-8_14</a>.
  short: B. Kragl, S. Qadeer, T.A. Henzinger, in:, Computer Aided Verification, Springer
    Nature, 2020, pp. 275–298.
date_created: 2020-08-03T11:45:35Z
date_published: 2020-07-14T00:00:00Z
date_updated: 2023-09-07T13:18:00Z
day: '14'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-030-53288-8_14
external_id:
  isi:
  - '000695276000014'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2020-08-06T08:14:54Z
  date_updated: 2020-08-06T08:14:54Z
  file_id: '8201'
  file_name: 2020_LNCS_Kragl.pdf
  file_size: 804237
  relation: main_file
  success: 1
file_date_updated: 2020-08-06T08:14:54Z
has_accepted_license: '1'
intvolume: '     12224'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 275-298
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: The Wittgenstein Prize
publication: Computer Aided Verification
publication_identifier:
  eisbn:
  - '9783030532888'
  eissn:
  - 1611-3349
  isbn:
  - '9783030532871'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '8332'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Refinement for structured concurrent programs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 12224
year: '2020'
...
---
_id: '14891'
abstract:
- lang: eng
  text: We give the first mathematically rigorous justification of the local density
    approximation in density functional theory. We provide a quantitative estimate
    on the difference between the grand-canonical Levy–Lieb energy of a given density
    (the lowest possible energy of all quantum states having this density) and the
    integral over the uniform electron gas energy of this density. The error involves
    gradient terms and justifies the use of the local density approximation in the
    situation where the density is very flat on sufficiently large regions in space.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Mathieu
  full_name: Lewin, Mathieu
  last_name: Lewin
- first_name: Elliott H.
  full_name: Lieb, Elliott H.
  last_name: Lieb
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Lewin M, Lieb EH, Seiringer R.  The local density approximation in density
    functional theory. <i>Pure and Applied Analysis</i>. 2020;2(1):35-73. doi:<a href="https://doi.org/10.2140/paa.2020.2.35">10.2140/paa.2020.2.35</a>
  apa: Lewin, M., Lieb, E. H., &#38; Seiringer, R. (2020).  The local density approximation
    in density functional theory. <i>Pure and Applied Analysis</i>. Mathematical Sciences
    Publishers. <a href="https://doi.org/10.2140/paa.2020.2.35">https://doi.org/10.2140/paa.2020.2.35</a>
  chicago: Lewin, Mathieu, Elliott H. Lieb, and Robert Seiringer. “ The Local Density
    Approximation in Density Functional Theory.” <i>Pure and Applied Analysis</i>.
    Mathematical Sciences Publishers, 2020. <a href="https://doi.org/10.2140/paa.2020.2.35">https://doi.org/10.2140/paa.2020.2.35</a>.
  ieee: M. Lewin, E. H. Lieb, and R. Seiringer, “ The local density approximation
    in density functional theory,” <i>Pure and Applied Analysis</i>, vol. 2, no. 1.
    Mathematical Sciences Publishers, pp. 35–73, 2020.
  ista: Lewin M, Lieb EH, Seiringer R. 2020.  The local density approximation in density
    functional theory. Pure and Applied Analysis. 2(1), 35–73.
  mla: Lewin, Mathieu, et al. “ The Local Density Approximation in Density Functional
    Theory.” <i>Pure and Applied Analysis</i>, vol. 2, no. 1, Mathematical Sciences
    Publishers, 2020, pp. 35–73, doi:<a href="https://doi.org/10.2140/paa.2020.2.35">10.2140/paa.2020.2.35</a>.
  short: M. Lewin, E.H. Lieb, R. Seiringer, Pure and Applied Analysis 2 (2020) 35–73.
date_created: 2024-01-28T23:01:44Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2024-01-29T09:01:12Z
day: '01'
department:
- _id: RoSe
doi: 10.2140/paa.2020.2.35
external_id:
  arxiv:
  - '1903.04046'
intvolume: '         2'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1903.04046
month: '01'
oa: 1
oa_version: Preprint
page: 35-73
publication: Pure and Applied Analysis
publication_identifier:
  eissn:
  - 2578-5885
  issn:
  - 2578-5893
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
scopus_import: '1'
status: public
title: ' The local density approximation in density functional theory'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2020'
...
---
_id: '15036'
abstract:
- lang: eng
  text: The assembly of a septin filament requires that homologous monomers must distinguish
    between one another in establishing appropriate interfaces with their neighbors.
    To understand this phenomenon at the molecular level, we present the first four
    crystal structures of heterodimeric septin complexes. We describe in detail the
    two distinct types of G-interface present within the octameric particles, which
    must polymerize to form filaments. These are formed between SEPT2 and SEPT6 and
    between SEPT7 and SEPT3, and their description permits an understanding of the
    structural basis for the selectivity necessary for correct filament assembly.
    By replacing SEPT6 by SEPT8 or SEPT11, it is possible to rationalize Kinoshita's
    postulate, which predicts the exchangeability of septins from within a subgroup.
    Switches I and II, which in classical small GTPases provide a mechanism for nucleotide-dependent
    conformational change, have been repurposed in septins to play a fundamental role
    in molecular recognition. Specifically, it is switch I which holds the key to
    discriminating between the two different G-interfaces. Moreover, residues which
    are characteristic for a given subgroup play subtle, but pivotal, roles in guaranteeing
    that the correct interfaces are formed.
article_processing_charge: No
article_type: original
author:
- first_name: Higor Vinícius Dias
  full_name: Rosa, Higor Vinícius Dias
  last_name: Rosa
- first_name: Diego Antonio
  full_name: Leonardo, Diego Antonio
  last_name: Leonardo
- first_name: Gabriel
  full_name: Brognara, Gabriel
  id: D96FFDA0-A884-11E9-9968-DC26E6697425
  last_name: Brognara
- first_name: José
  full_name: Brandão-Neto, José
  last_name: Brandão-Neto
- first_name: Humberto
  full_name: D'Muniz Pereira, Humberto
  last_name: D'Muniz Pereira
- first_name: Ana Paula Ulian
  full_name: Araújo, Ana Paula Ulian
  last_name: Araújo
- first_name: Richard Charles
  full_name: Garratt, Richard Charles
  last_name: Garratt
citation:
  ama: 'Rosa HVD, Leonardo DA, Brognara G, et al. Molecular recognition at septin
    interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. 2020;432(21):5784-5801.
    doi:<a href="https://doi.org/10.1016/j.jmb.2020.09.001">10.1016/j.jmb.2020.09.001</a>'
  apa: 'Rosa, H. V. D., Leonardo, D. A., Brognara, G., Brandão-Neto, J., D’Muniz Pereira,
    H., Araújo, A. P. U., &#38; Garratt, R. C. (2020). Molecular recognition at septin
    interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.jmb.2020.09.001">https://doi.org/10.1016/j.jmb.2020.09.001</a>'
  chicago: 'Rosa, Higor Vinícius Dias, Diego Antonio Leonardo, Gabriel Brognara, José
    Brandão-Neto, Humberto D’Muniz Pereira, Ana Paula Ulian Araújo, and Richard Charles
    Garratt. “Molecular Recognition at Septin Interfaces: The Switches Hold the Key.”
    <i>Journal of Molecular Biology</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.jmb.2020.09.001">https://doi.org/10.1016/j.jmb.2020.09.001</a>.'
  ieee: 'H. V. D. Rosa <i>et al.</i>, “Molecular recognition at septin interfaces:
    The switches hold the key,” <i>Journal of Molecular Biology</i>, vol. 432, no.
    21. Elsevier, pp. 5784–5801, 2020.'
  ista: 'Rosa HVD, Leonardo DA, Brognara G, Brandão-Neto J, D’Muniz Pereira H, Araújo
    APU, Garratt RC. 2020. Molecular recognition at septin interfaces: The switches
    hold the key. Journal of Molecular Biology. 432(21), 5784–5801.'
  mla: 'Rosa, Higor Vinícius Dias, et al. “Molecular Recognition at Septin Interfaces:
    The Switches Hold the Key.” <i>Journal of Molecular Biology</i>, vol. 432, no.
    21, Elsevier, 2020, pp. 5784–801, doi:<a href="https://doi.org/10.1016/j.jmb.2020.09.001">10.1016/j.jmb.2020.09.001</a>.'
  short: H.V.D. Rosa, D.A. Leonardo, G. Brognara, J. Brandão-Neto, H. D’Muniz Pereira,
    A.P.U. Araújo, R.C. Garratt, Journal of Molecular Biology 432 (2020) 5784–5801.
date_created: 2024-02-28T08:50:34Z
date_published: 2020-10-02T00:00:00Z
date_updated: 2024-02-28T12:37:54Z
day: '02'
department:
- _id: MaLo
doi: 10.1016/j.jmb.2020.09.001
external_id:
  pmid:
  - '32910969'
intvolume: '       432'
issue: '21'
keyword:
- Molecular Biology
- Structural Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.jmb.2020.09.001
month: '10'
oa: 1
oa_version: Published Version
page: 5784-5801
pmid: 1
publication: Journal of Molecular Biology
publication_identifier:
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Molecular recognition at septin interfaces: The switches hold the key'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 432
year: '2020'
...
---
_id: '15037'
abstract:
- lang: eng
  text: Protein abundance and localization at the plasma membrane (PM) shapes plant
    development and mediates adaptation to changing environmental conditions. It is
    regulated by ubiquitination, a post-translational modification crucial for the
    proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation.
    To understand the significance and the variety of roles played by this reversible
    modification, the function of ubiquitin receptors, which translate the ubiquitin
    signature into a cellular response, needs to be elucidated. In this study, we
    show that TOL (TOM1-like) proteins function in plants as multivalent ubiquitin
    receptors, governing ubiquitinated cargo delivery to the vacuole via the conserved
    Endosomal Sorting Complex Required for Transport (ESCRT) pathway. TOL2 and TOL6
    interact with components of the ESCRT machinery and bind to K63-linked ubiquitin
    via two tandemly arranged conserved ubiquitin-binding domains. Mutation of these
    domains results not only in a loss of ubiquitin binding but also altered localization,
    abolishing TOL6 ubiquitin receptor activity. Function and localization of TOL6
    is itself regulated by ubiquitination, whereby TOL6 ubiquitination potentially
    modulates degradation of PM-localized cargoes, assisting in the fine-tuning of
    the delicate interplay between protein recycling and downregulation. Taken together,
    our findings demonstrate the function and regulation of a ubiquitin receptor that
    mediates vacuolar degradation of PM proteins in higher plants.
article_processing_charge: No
article_type: original
author:
- first_name: Jeanette
  full_name: Moulinier-Anzola, Jeanette
  last_name: Moulinier-Anzola
- first_name: Maximilian
  full_name: Schwihla, Maximilian
  last_name: Schwihla
- first_name: Lucinda
  full_name: De-Araújo, Lucinda
  last_name: De-Araújo
- first_name: Christina
  full_name: Artner, Christina
  id: 45DF286A-F248-11E8-B48F-1D18A9856A87
  last_name: Artner
- first_name: Lisa
  full_name: Jörg, Lisa
  last_name: Jörg
- first_name: Nataliia
  full_name: Konstantinova, Nataliia
  last_name: Konstantinova
- first_name: Christian
  full_name: Luschnig, Christian
  last_name: Luschnig
- first_name: Barbara
  full_name: Korbei, Barbara
  last_name: Korbei
citation:
  ama: Moulinier-Anzola J, Schwihla M, De-Araújo L, et al. TOLs function as ubiquitin
    receptors in the early steps of the ESCRT pathway in higher plants. <i>Molecular
    Plant</i>. 2020;13(5):717-731. doi:<a href="https://doi.org/10.1016/j.molp.2020.02.012">10.1016/j.molp.2020.02.012</a>
  apa: Moulinier-Anzola, J., Schwihla, M., De-Araújo, L., Artner, C., Jörg, L., Konstantinova,
    N., … Korbei, B. (2020). TOLs function as ubiquitin receptors in the early steps
    of the ESCRT pathway in higher plants. <i>Molecular Plant</i>. Elsevier. <a href="https://doi.org/10.1016/j.molp.2020.02.012">https://doi.org/10.1016/j.molp.2020.02.012</a>
  chicago: Moulinier-Anzola, Jeanette, Maximilian Schwihla, Lucinda De-Araújo, Christina
    Artner, Lisa Jörg, Nataliia Konstantinova, Christian Luschnig, and Barbara Korbei.
    “TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway
    in Higher Plants.” <i>Molecular Plant</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.molp.2020.02.012">https://doi.org/10.1016/j.molp.2020.02.012</a>.
  ieee: J. Moulinier-Anzola <i>et al.</i>, “TOLs function as ubiquitin receptors in
    the early steps of the ESCRT pathway in higher plants,” <i>Molecular Plant</i>,
    vol. 13, no. 5. Elsevier, pp. 717–731, 2020.
  ista: Moulinier-Anzola J, Schwihla M, De-Araújo L, Artner C, Jörg L, Konstantinova
    N, Luschnig C, Korbei B. 2020. TOLs function as ubiquitin receptors in the early
    steps of the ESCRT pathway in higher plants. Molecular Plant. 13(5), 717–731.
  mla: Moulinier-Anzola, Jeanette, et al. “TOLs Function as Ubiquitin Receptors in
    the Early Steps of the ESCRT Pathway in Higher Plants.” <i>Molecular Plant</i>,
    vol. 13, no. 5, Elsevier, 2020, pp. 717–31, doi:<a href="https://doi.org/10.1016/j.molp.2020.02.012">10.1016/j.molp.2020.02.012</a>.
  short: J. Moulinier-Anzola, M. Schwihla, L. De-Araújo, C. Artner, L. Jörg, N. Konstantinova,
    C. Luschnig, B. Korbei, Molecular Plant 13 (2020) 717–731.
date_created: 2024-02-28T08:55:56Z
date_published: 2020-05-04T00:00:00Z
date_updated: 2024-02-28T12:41:52Z
day: '04'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1016/j.molp.2020.02.012
external_id:
  pmid:
  - '32087370'
file:
- access_level: open_access
  checksum: c538a5008f7827f62d17d40a3bfabe65
  content_type: application/pdf
  creator: dernst
  date_created: 2024-02-28T12:39:56Z
  date_updated: 2024-02-28T12:39:56Z
  file_id: '15038'
  file_name: 2020_MolecularPlant_MoulinierAnzola.pdf
  file_size: 3089212
  relation: main_file
  success: 1
file_date_updated: 2024-02-28T12:39:56Z
has_accepted_license: '1'
intvolume: '        13'
issue: '5'
keyword:
- Plant Science
- Molecular Biology
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 717-731
pmid: 1
publication: Molecular Plant
publication_identifier:
  issn:
  - 1674-2052
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway
  in higher plants
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2020'
...
---
_id: '15055'
abstract:
- lang: eng
  text: <jats:p>Markov decision processes (MDPs) are the defacto framework for sequential
    decision making in the presence of stochastic uncertainty. A classical optimization
    criterion for MDPs is to maximize the expected discounted-sum payoff, which ignores
    low probability catastrophic events with highly negative impact on the system.
    On the other hand, risk-averse policies require the probability of undesirable
    events to be below a given threshold, but they do not account for optimization
    of the expected payoff. We consider MDPs with discounted-sum payoff with failure
    states which represent catastrophic outcomes. The objective of risk-constrained
    planning is to maximize the expected discounted-sum payoff among risk-averse policies
    that ensure the probability to encounter a failure state is below a desired threshold.
    Our main contribution is an efficient risk-constrained planning algorithm that
    combines UCT-like search with a predictor learned through interaction with the
    MDP (in the style of AlphaZero) and with a risk-constrained action selection via
    linear programming. We demonstrate the effectiveness of our approach with experiments
    on classical MDPs from the literature, including benchmarks with an order of 106
    states.</jats:p>
acknowledgement: Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF)
  NFN Grant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Tomas Brazdil is
  supported by the Grant Agency of Masaryk University grant no. MUNI/G/0739/2017 and
  by the Czech Science Foundation grant No. 18-11193S. Petr Novotny and Jirı Vahala
  are supported by the Czech Science Foundation grant No. GJ19-15134Y.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tomáš
  full_name: Brázdil, Tomáš
  last_name: Brázdil
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Petr
  full_name: Novotný, Petr
  last_name: Novotný
- first_name: Jiří
  full_name: Vahala, Jiří
  last_name: Vahala
citation:
  ama: Brázdil T, Chatterjee K, Novotný P, Vahala J. Reinforcement learning of risk-constrained
    policies in Markov decision processes. <i>Proceedings of the 34th AAAI Conference
    on Artificial Intelligence</i>. 2020;34(06):9794-9801. doi:<a href="https://doi.org/10.1609/aaai.v34i06.6531">10.1609/aaai.v34i06.6531</a>
  apa: 'Brázdil, T., Chatterjee, K., Novotný, P., &#38; Vahala, J. (2020). Reinforcement
    learning of risk-constrained policies in Markov decision processes. <i>Proceedings
    of the 34th AAAI Conference on Artificial Intelligence</i>. New York, NY, United
    States: Association for the Advancement of Artificial Intelligence. <a href="https://doi.org/10.1609/aaai.v34i06.6531">https://doi.org/10.1609/aaai.v34i06.6531</a>'
  chicago: Brázdil, Tomáš, Krishnendu Chatterjee, Petr Novotný, and Jiří Vahala. “Reinforcement
    Learning of Risk-Constrained Policies in Markov Decision Processes.” <i>Proceedings
    of the 34th AAAI Conference on Artificial Intelligence</i>. Association for the
    Advancement of Artificial Intelligence, 2020. <a href="https://doi.org/10.1609/aaai.v34i06.6531">https://doi.org/10.1609/aaai.v34i06.6531</a>.
  ieee: T. Brázdil, K. Chatterjee, P. Novotný, and J. Vahala, “Reinforcement learning
    of risk-constrained policies in Markov decision processes,” <i>Proceedings of
    the 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 06. Association
    for the Advancement of Artificial Intelligence, pp. 9794–9801, 2020.
  ista: Brázdil T, Chatterjee K, Novotný P, Vahala J. 2020. Reinforcement learning
    of risk-constrained policies in Markov decision processes. Proceedings of the
    34th AAAI Conference on Artificial Intelligence. 34(06), 9794–9801.
  mla: Brázdil, Tomáš, et al. “Reinforcement Learning of Risk-Constrained Policies
    in Markov Decision Processes.” <i>Proceedings of the 34th AAAI Conference on Artificial
    Intelligence</i>, vol. 34, no. 06, Association for the Advancement of Artificial
    Intelligence, 2020, pp. 9794–801, doi:<a href="https://doi.org/10.1609/aaai.v34i06.6531">10.1609/aaai.v34i06.6531</a>.
  short: T. Brázdil, K. Chatterjee, P. Novotný, J. Vahala, Proceedings of the 34th
    AAAI Conference on Artificial Intelligence 34 (2020) 9794–9801.
conference:
  end_date: 2020-02-12
  location: New York, NY, United States
  name: 'AAAI: Conference on Artificial Intelligence'
  start_date: 2020-02-07
date_created: 2024-03-04T08:07:22Z
date_published: 2020-04-03T00:00:00Z
date_updated: 2024-03-04T08:30:16Z
day: '03'
department:
- _id: KrCh
doi: 10.1609/aaai.v34i06.6531
external_id:
  arxiv:
  - '2002.12086'
intvolume: '        34'
issue: '06'
keyword:
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2002.12086
month: '04'
oa: 1
oa_version: Preprint
page: 9794-9801
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
publication: Proceedings of the 34th AAAI Conference on Artificial Intelligence
publication_identifier:
  issn:
  - 2374-3468
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
status: public
title: Reinforcement learning of risk-constrained policies in Markov decision processes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2020'
...
---
_id: '15057'
abstract:
- lang: eng
  text: Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear
    protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions
    in cell division and germline proliferation. However, the role of VRK-1 in postmitotic
    cells and adult life span remains unknown. Here, we show that VRK-1 increases
    organismal longevity by activating the cellular energy sensor, AMP-activated protein
    kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1
    in the soma of adult C. elegans increased life span and, conversely, inhibition
    of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred
    by mutations that inhibit C. elegans mitochondrial respiration, which requires
    AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and
    cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1,
    promotes longevity through AMPK activation, and this function appears to be conserved
    between C. elegans and humans.
acknowledgement: 'This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366
  funded by the Korean Government (MSIT) through the National Research Foundation
  (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440)
  funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. '
article_number: aaw7824
article_processing_charge: No
article_type: original
author:
- first_name: Sangsoon
  full_name: Park, Sangsoon
  last_name: Park
- first_name: Murat
  full_name: Artan, Murat
  id: C407B586-6052-11E9-B3AE-7006E6697425
  last_name: Artan
  orcid: 0000-0001-8945-6992
- first_name: Seung Hyun
  full_name: Han, Seung Hyun
  last_name: Han
- first_name: Hae-Eun H.
  full_name: Park, Hae-Eun H.
  last_name: Park
- first_name: Yoonji
  full_name: Jung, Yoonji
  last_name: Jung
- first_name: Ara B.
  full_name: Hwang, Ara B.
  last_name: Hwang
- first_name: Won Sik
  full_name: Shin, Won Sik
  last_name: Shin
- first_name: Kyong-Tai
  full_name: Kim, Kyong-Tai
  last_name: Kim
- first_name: Seung-Jae V.
  full_name: Lee, Seung-Jae V.
  last_name: Lee
citation:
  ama: Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK
    via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href="https://doi.org/10.1126/sciadv.aaw7824">10.1126/sciadv.aaw7824</a>
  apa: Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., …
    Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation.
    <i>Science Advances</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/sciadv.aaw7824">https://doi.org/10.1126/sciadv.aaw7824</a>
  chicago: Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung,
    Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends
    Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2020. <a href="https://doi.org/10.1126/sciadv.aaw7824">https://doi.org/10.1126/sciadv.aaw7824</a>.
  ieee: S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via
    phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association
    for the Advancement of Science, 2020.
  ista: Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee
    S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation.
    Science Advances. 6(27), aaw7824.
  mla: Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.”
    <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the
    Advancement of Science, 2020, doi:<a href="https://doi.org/10.1126/sciadv.aaw7824">10.1126/sciadv.aaw7824</a>.
  short: S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin,
    K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).
date_created: 2024-03-04T09:41:57Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2024-03-04T09:52:09Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1126/sciadv.aaw7824
file:
- access_level: open_access
  checksum: a37157cd0de709dce5fe03f4a31cd0b6
  content_type: application/pdf
  creator: dernst
  date_created: 2024-03-04T09:46:41Z
  date_updated: 2024-03-04T09:46:41Z
  file_id: '15058'
  file_name: 2020_ScienceAdvances_Park.pdf
  file_size: 1864415
  relation: main_file
  success: 1
file_date_updated: 2024-03-04T09:46:41Z
has_accepted_license: '1'
intvolume: '         6'
issue: '27'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: VRK-1 extends life span by activation of AMPK via phosphorylation
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '15059'
abstract:
- lang: eng
  text: "In this paper we present a room temperature radiometer that can eliminate
    the need of using cryostats in satellite payload reducing its weight and improving
    reliability. The proposed radiometer is based on an electro-optic upconverter
    that boosts up microwave photons energy by upconverting them into an optical domain
    what makes them immune to thermal noise even if operating at room temperature.
    The converter uses a high-quality factor whispering gallery\r\nmode (WGM) resonator
    providing naturally narrow bandwidth and therefore might be useful for applications
    like microwave hyperspectral sensing. The upconversion process is explained by\r\nproviding
    essential information about photon conversion efficiency and sensitivity. To prove
    the concept, we describe an experiment which shows state-of-the-art photon conversion
    efficiency n=10-5 per mW of pump power at the frequency of 80 GHz."
acknowledgement: This work has been financially supported by Comunidad de Madrid S2018/NMT-4333
  ARTINLARA-CM projects, and “FUNDACIÓN SENER” REFTA projects.
article_processing_charge: No
author:
- first_name: Michal
  full_name: Wasiak, Michal
  last_name: Wasiak
- first_name: Gabriel Santamaria
  full_name: Botello, Gabriel Santamaria
  last_name: Botello
- first_name: Kerlos Atia
  full_name: Abdalmalak, Kerlos Atia
  last_name: Abdalmalak
- first_name: Florian
  full_name: Sedlmeir, Florian
  last_name: Sedlmeir
- first_name: Alfredo R
  full_name: Rueda Sanchez, Alfredo R
  id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
  last_name: Rueda Sanchez
  orcid: 0000-0001-6249-5860
- first_name: Daniel
  full_name: Segovia-Vargas, Daniel
  last_name: Segovia-Vargas
- first_name: Harald G. L.
  full_name: Schwefel, Harald G. L.
  last_name: Schwefel
- first_name: Luis Enrique Garcia
  full_name: Munoz, Luis Enrique Garcia
  last_name: Munoz
citation:
  ama: 'Wasiak M, Botello GS, Abdalmalak KA, et al. Compact millimeter and submillimeter-wave
    photonic radiometer for cubesats. In: <i>14th European Conference on Antennas
    and Propagation</i>. IEEE; 2020. doi:<a href="https://doi.org/10.23919/eucap48036.2020.9135962">10.23919/eucap48036.2020.9135962</a>'
  apa: 'Wasiak, M., Botello, G. S., Abdalmalak, K. A., Sedlmeir, F., Rueda Sanchez,
    A. R., Segovia-Vargas, D., … Munoz, L. E. G. (2020). Compact millimeter and submillimeter-wave
    photonic radiometer for cubesats. In <i>14th European Conference on Antennas and
    Propagation</i>. Copenhagen, Denmark: IEEE. <a href="https://doi.org/10.23919/eucap48036.2020.9135962">https://doi.org/10.23919/eucap48036.2020.9135962</a>'
  chicago: Wasiak, Michal, Gabriel Santamaria Botello, Kerlos Atia Abdalmalak, Florian
    Sedlmeir, Alfredo R Rueda Sanchez, Daniel Segovia-Vargas, Harald G. L. Schwefel,
    and Luis Enrique Garcia Munoz. “Compact Millimeter and Submillimeter-Wave Photonic
    Radiometer for Cubesats.” In <i>14th European Conference on Antennas and Propagation</i>.
    IEEE, 2020. <a href="https://doi.org/10.23919/eucap48036.2020.9135962">https://doi.org/10.23919/eucap48036.2020.9135962</a>.
  ieee: M. Wasiak <i>et al.</i>, “Compact millimeter and submillimeter-wave photonic
    radiometer for cubesats,” in <i>14th European Conference on Antennas and Propagation</i>,
    Copenhagen, Denmark, 2020.
  ista: 'Wasiak M, Botello GS, Abdalmalak KA, Sedlmeir F, Rueda Sanchez AR, Segovia-Vargas
    D, Schwefel HGL, Munoz LEG. 2020. Compact millimeter and submillimeter-wave photonic
    radiometer for cubesats. 14th European Conference on Antennas and Propagation.
    EuCAP: European Conference on Antennas and Propagation.'
  mla: Wasiak, Michal, et al. “Compact Millimeter and Submillimeter-Wave Photonic
    Radiometer for Cubesats.” <i>14th European Conference on Antennas and Propagation</i>,
    IEEE, 2020, doi:<a href="https://doi.org/10.23919/eucap48036.2020.9135962">10.23919/eucap48036.2020.9135962</a>.
  short: M. Wasiak, G.S. Botello, K.A. Abdalmalak, F. Sedlmeir, A.R. Rueda Sanchez,
    D. Segovia-Vargas, H.G.L. Schwefel, L.E.G. Munoz, in:, 14th European Conference
    on Antennas and Propagation, IEEE, 2020.
conference:
  end_date: 2020-03-20
  location: Copenhagen, Denmark
  name: 'EuCAP: European Conference on Antennas and Propagation'
  start_date: 2020-03-15
date_created: 2024-03-04T09:57:48Z
date_published: 2020-07-08T00:00:00Z
date_updated: 2024-03-04T10:02:49Z
day: '08'
department:
- _id: JoFi
doi: 10.23919/eucap48036.2020.9135962
language:
- iso: eng
month: '07'
oa_version: None
publication: 14th European Conference on Antennas and Propagation
publication_identifier:
  eisbn:
  - '9788831299008'
publication_status: published
publisher: IEEE
quality_controlled: '1'
status: public
title: Compact millimeter and submillimeter-wave photonic radiometer for cubesats
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '15061'
abstract:
- lang: eng
  text: The actin cytoskeleton, a dynamic network of actin filaments and associated
    F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins
    are major F-actin bundlers that are inhibited by Ca2+ in nonmuscle cells. Here
    we report the mechanism of Ca2+-mediated regulation of Entamoeba histolytica α-actinin-2
    (EhActn2) with features expected for the common ancestor of Entamoeba and higher
    eukaryotic α-actinins. Crystal structures of Ca2+-free and Ca2+-bound EhActn2
    reveal a calmodulin-like domain (CaMD) uniquely inserted within the rod domain.
    Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD
    for Ca2+, binding of which can only be regulated in the presence of physiological
    concentrations of Mg2+. Ca2+ binding triggers an increase in protein multidomain
    rigidity, reducing conformational flexibility of F-actin–binding domains via interdomain
    cross-talk and consequently inhibiting F-actin bundling. In vivo studies uncover
    that EhActn2 plays an important role in phagocytic cup formation and might constitute
    a new drug target for amoebic dysentery.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We thank the staff of the macromolecular crystallography (MX) and
  SAXS beamlines at the European Synchrotron Radiation facility, Diamond, and Swiss
  Light Source for excellent support, and the Life Sciences Facility of the Institute
  of Science and Technology Austria for usage of the rheometer. We thank Life Sciences
  editors for editing assistance. EM data were\r\nrecorded at the EM Facility of the
  Vienna BioCenter Core Facilities (Austria). Confocal microscopy was carried out
  at the Advanced Instrument Research Facility, Jawaharlal Nehru University. K.D.-C.’s
  research was supported by the Initial Training Network MUZIC (ITN-MUZIC) (N°238423),
  Austrian Science Fund (FWF) Projects I525, I1593, P22276, P19060, and W1221, Laura
  Bassi Centre of Optimized Structural Studies (N°253275), a Wellcome Trust Collaborative
  Award (201543/Z/16/Z), COST Action BM1405, Vienna Science and Technology Fund (WWTF)
  Chemical Biology Project LS17-008, and Christian Doppler Laboratory for High-Content
  Structural Biology and Biotechnology. K.Z., J.L.A., C.S., E.A.G., and A.S. were
  supported by the University of Vienna, J.K. by a Wellcome Trust Collaborative Award
  and by the Centre of Optimized Structural Studies, M.P. by FWF Project I1593, E.d.A.R.
  ITN-MUZIC, and FWF Projects I525 and I1593, and T.C.M. and L.C. by FWF Project I
  2408-B22. E.A.G. acknowledges the PhD program Structure and Interaction of Biological
  Macromolecules. M.B. acknowledges the University Grant Commission, India, for a
  senior research fellowship. A.B. acknowledges a JC Bose Fellowship from the Science
  Engineering Research Council. "
article_processing_charge: No
article_type: original
author:
- first_name: Nikos
  full_name: Pinotsis, Nikos
  last_name: Pinotsis
- first_name: Karolina
  full_name: Zielinska, Karolina
  last_name: Zielinska
- first_name: Mrigya
  full_name: Babuta, Mrigya
  last_name: Babuta
- first_name: Joan L.
  full_name: Arolas, Joan L.
  last_name: Arolas
- first_name: Julius
  full_name: Kostan, Julius
  last_name: Kostan
- first_name: Muhammad Bashir
  full_name: Khan, Muhammad Bashir
  last_name: Khan
- first_name: Claudia
  full_name: Schreiner, Claudia
  last_name: Schreiner
- first_name: Anita P
  full_name: Testa Salmazo, Anita P
  id: 41F1F098-F248-11E8-B48F-1D18A9856A87
  last_name: Testa Salmazo
- first_name: Luciano
  full_name: Ciccarelli, Luciano
  last_name: Ciccarelli
- first_name: Martin
  full_name: Puchinger, Martin
  last_name: Puchinger
- first_name: Eirini A.
  full_name: Gkougkoulia, Eirini A.
  last_name: Gkougkoulia
- first_name: Euripedes de Almeida
  full_name: Ribeiro, Euripedes de Almeida
  last_name: Ribeiro
- first_name: Thomas C.
  full_name: Marlovits, Thomas C.
  last_name: Marlovits
- first_name: Alok
  full_name: Bhattacharya, Alok
  last_name: Bhattacharya
- first_name: Kristina
  full_name: Djinovic-Carugo, Kristina
  last_name: Djinovic-Carugo
citation:
  ama: Pinotsis N, Zielinska K, Babuta M, et al. Calcium modulates the domain flexibility
    and function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings
    of the National Academy of Sciences</i>. 2020;117(36):22101-22112. doi:<a href="https://doi.org/10.1073/pnas.1917269117">10.1073/pnas.1917269117</a>
  apa: Pinotsis, N., Zielinska, K., Babuta, M., Arolas, J. L., Kostan, J., Khan, M.
    B., … Djinovic-Carugo, K. (2020). Calcium modulates the domain flexibility and
    function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings of
    the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.1917269117">https://doi.org/10.1073/pnas.1917269117</a>
  chicago: Pinotsis, Nikos, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius
    Kostan, Muhammad Bashir Khan, Claudia Schreiner, et al. “Calcium Modulates the
    Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.”
    <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National
    Academy of Sciences, 2020. <a href="https://doi.org/10.1073/pnas.1917269117">https://doi.org/10.1073/pnas.1917269117</a>.
  ieee: N. Pinotsis <i>et al.</i>, “Calcium modulates the domain flexibility and function
    of an α-actinin similar to the ancestral α-actinin,” <i>Proceedings of the National
    Academy of Sciences</i>, vol. 117, no. 36. Proceedings of the National Academy
    of Sciences, pp. 22101–22112, 2020.
  ista: Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner
    C, Testa Salmazo AP, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro E de A,
    Marlovits TC, Bhattacharya A, Djinovic-Carugo K. 2020. Calcium modulates the domain
    flexibility and function of an α-actinin similar to the ancestral α-actinin. Proceedings
    of the National Academy of Sciences. 117(36), 22101–22112.
  mla: Pinotsis, Nikos, et al. “Calcium Modulates the Domain Flexibility and Function
    of an α-Actinin Similar to the Ancestral α-Actinin.” <i>Proceedings of the National
    Academy of Sciences</i>, vol. 117, no. 36, Proceedings of the National Academy
    of Sciences, 2020, pp. 22101–12, doi:<a href="https://doi.org/10.1073/pnas.1917269117">10.1073/pnas.1917269117</a>.
  short: N. Pinotsis, K. Zielinska, M. Babuta, J.L. Arolas, J. Kostan, M.B. Khan,
    C. Schreiner, A.P. Testa Salmazo, L. Ciccarelli, M. Puchinger, E.A. Gkougkoulia,
    E. de A. Ribeiro, T.C. Marlovits, A. Bhattacharya, K. Djinovic-Carugo, Proceedings
    of the National Academy of Sciences 117 (2020) 22101–22112.
date_created: 2024-03-04T10:03:52Z
date_published: 2020-09-08T00:00:00Z
date_updated: 2024-03-04T10:14:44Z
day: '08'
department:
- _id: CaBe
doi: 10.1073/pnas.1917269117
external_id:
  pmid:
  - '32848067'
intvolume: '       117'
issue: '36'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1073/pnas.191726911
month: '09'
oa: 1
oa_version: Published Version
page: 22101-22112
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
status: public
title: Calcium modulates the domain flexibility and function of an α-actinin similar
  to the ancestral α-actinin
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 117
year: '2020'
...
