---
_id: '10631'
abstract:
- lang: eng
  text: We combine experimental and theoretical approaches to explore excited rotational
    states of molecules embedded in helium nanodroplets using CS2 and I2 as examples.
    Laser-induced nonadiabatic molecular alignment is employed to measure spectral
    lines for rotational states extending beyond those initially populated at the
    0.37 K droplet temperature. We construct a simple quantum-mechanical model, based
    on a linear rotor coupled to a single-mode bosonic bath, to determine the rotational
    energy structure in its entirety. The calculated and measured spectral lines are
    in good agreement. We show that the effect of the surrounding superfluid on molecular
    rotation can be rationalized by a single quantity, the angular momentum, transferred
    from the molecule to the droplet.
acknowledgement: I.C. acknowledges the support by the European Union’s Horizon 2020
  research and innovation programme under the Marie Sklodowska-Curie Grant Agreement
  No. 665385. G.B. acknowledges support from the Austrian Science Fund (FWF), under
  project No. M2461-N27. M.L. acknowledges support by the Austrian Science Fund (FWF),
  under project No. P29902-N27, and by the European Research Council (ERC) Starting
  Grant No. 801770 (ANGULON). H.S acknowledges support from the European Research
  Council-AdG (Project No. 320459, DropletControl) and from The Villum Foundation
  through a Villum Investigator grant no. 25886.
article_number: L061303
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Igor
  full_name: Cherepanov, Igor
  id: 339C7E5A-F248-11E8-B48F-1D18A9856A87
  last_name: Cherepanov
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Constant A.
  full_name: Schouder, Constant A.
  last_name: Schouder
- first_name: Adam S.
  full_name: Chatterley, Adam S.
  last_name: Chatterley
- first_name: Simon H.
  full_name: Albrechtsen, Simon H.
  last_name: Albrechtsen
- first_name: Alberto Viñas
  full_name: Muñoz, Alberto Viñas
  last_name: Muñoz
- first_name: Lars
  full_name: Christiansen, Lars
  last_name: Christiansen
- first_name: Henrik
  full_name: Stapelfeldt, Henrik
  last_name: Stapelfeldt
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Cherepanov I, Bighin G, Schouder CA, et al. Excited rotational states of molecules
    in a superfluid. <i>Physical Review A</i>. 2021;104(6). doi:<a href="https://doi.org/10.1103/PhysRevA.104.L061303">10.1103/PhysRevA.104.L061303</a>
  apa: Cherepanov, I., Bighin, G., Schouder, C. A., Chatterley, A. S., Albrechtsen,
    S. H., Muñoz, A. V., … Lemeshko, M. (2021). Excited rotational states of molecules
    in a superfluid. <i>Physical Review A</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevA.104.L061303">https://doi.org/10.1103/PhysRevA.104.L061303</a>
  chicago: Cherepanov, Igor, Giacomo Bighin, Constant A. Schouder, Adam S. Chatterley,
    Simon H. Albrechtsen, Alberto Viñas Muñoz, Lars Christiansen, Henrik Stapelfeldt,
    and Mikhail Lemeshko. “Excited Rotational States of Molecules in a Superfluid.”
    <i>Physical Review A</i>. American Physical Society, 2021. <a href="https://doi.org/10.1103/PhysRevA.104.L061303">https://doi.org/10.1103/PhysRevA.104.L061303</a>.
  ieee: I. Cherepanov <i>et al.</i>, “Excited rotational states of molecules in a
    superfluid,” <i>Physical Review A</i>, vol. 104, no. 6. American Physical Society,
    2021.
  ista: Cherepanov I, Bighin G, Schouder CA, Chatterley AS, Albrechtsen SH, Muñoz
    AV, Christiansen L, Stapelfeldt H, Lemeshko M. 2021. Excited rotational states
    of molecules in a superfluid. Physical Review A. 104(6), L061303.
  mla: Cherepanov, Igor, et al. “Excited Rotational States of Molecules in a Superfluid.”
    <i>Physical Review A</i>, vol. 104, no. 6, L061303, American Physical Society,
    2021, doi:<a href="https://doi.org/10.1103/PhysRevA.104.L061303">10.1103/PhysRevA.104.L061303</a>.
  short: I. Cherepanov, G. Bighin, C.A. Schouder, A.S. Chatterley, S.H. Albrechtsen,
    A.V. Muñoz, L. Christiansen, H. Stapelfeldt, M. Lemeshko, Physical Review A 104
    (2021).
date_created: 2022-01-16T23:01:29Z
date_published: 2021-12-30T00:00:00Z
date_updated: 2024-08-07T07:16:52Z
day: '30'
department:
- _id: MiLe
doi: 10.1103/PhysRevA.104.L061303
ec_funded: 1
external_id:
  arxiv:
  - '2107.00468'
  isi:
  - '000739618300001'
intvolume: '       104'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://128.84.4.18/abs/2107.00468
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29902
  name: Quantum rotations in the presence of a many-body environment
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 26986C82-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02641
  name: A path-integral approach to composite impurities
publication: Physical Review A
publication_identifier:
  eissn:
  - 2469-9934
  issn:
  - 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Excited rotational states of molecules in a superfluid
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 104
year: '2021'
...
---
_id: '10635'
abstract:
- lang: eng
  text: The brain efficiently performs nonlinear computations through its intricate
    networks of spiking neurons, but how this is done remains elusive. While nonlinear
    computations can be implemented successfully in spiking neural networks, this
    requires supervised training and the resulting connectivity can be hard to interpret.
    In contrast, the required connectivity for any computation in the form of a linear
    dynamical system can be directly derived and understood with the spike coding
    network (SCN) framework. These networks also have biologically realistic activity
    patterns and are highly robust to cell death. Here we extend the SCN framework
    to directly implement any polynomial dynamical system, without the need for training.
    This results in networks requiring a mix of synapse types (fast, slow, and multiplicative),
    which we term multiplicative spike coding networks (mSCNs). Using mSCNs, we demonstrate
    how to directly derive the required connectivity for several nonlinear dynamical
    systems. We also show how to carry out higher-order polynomials with coupled networks
    that use only pair-wise multiplicative synapses, and provide expected numbers
    of connections for each synapse type. Overall, our work demonstrates a novel method
    for implementing nonlinear computations in spiking neural networks, while keeping
    the attractive features of standard SCNs (robustness, realistic activity patterns,
    and interpretable connectivity). Finally, we discuss the biological plausibility
    of our approach, and how the high accuracy and robustness of the approach may
    be of interest for neuromorphic computing.
acknowledgement: "A preprint version of this article has been peer-reviewed and recommended
  by Peer Community In Neuroscience (DOI link to the recommendation: https://doi.org/10.24072/pci.cneuro.100003).\r\nWe
  thank Christian Machens and Nuno Calaim for useful discussions on the project. This
  report\r\ncame out of a collaboration started at the CAJAL Advanced Neuroscience
  Training Programme in\r\nComputational Neuroscience in Lisbon, Portugal, during
  the 2019 summer. The authors would\r\nlike to thank the participants, TAs, lecturers,
  and organizers of the summer school. SWK was\r\nsupported by the Simons Collaboration
  on the Global Brain (543009). WFP was supported by\r\nFCT (032077). MN was supported
  by European Union Horizon 2020 (665385).\r\n"
article_number: e68
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Michele
  full_name: Nardin, Michele
  id: 30BD0376-F248-11E8-B48F-1D18A9856A87
  last_name: Nardin
  orcid: 0000-0001-8849-6570
- first_name: James W.
  full_name: Phillips, James W.
  last_name: Phillips
- first_name: William F.
  full_name: Podlaski, William F.
  last_name: Podlaski
- first_name: Sander W.
  full_name: Keemink, Sander W.
  last_name: Keemink
citation:
  ama: Nardin M, Phillips JW, Podlaski WF, Keemink SW. Nonlinear computations in spiking
    neural networks through multiplicative synapses. <i>Peer Community Journal</i>.
    2021;1. doi:<a href="https://doi.org/10.24072/pcjournal.69">10.24072/pcjournal.69</a>
  apa: Nardin, M., Phillips, J. W., Podlaski, W. F., &#38; Keemink, S. W. (2021).
    Nonlinear computations in spiking neural networks through multiplicative synapses.
    <i>Peer Community Journal</i>. Centre Mersenne ; Peer Community In. <a href="https://doi.org/10.24072/pcjournal.69">https://doi.org/10.24072/pcjournal.69</a>
  chicago: Nardin, Michele, James W. Phillips, William F. Podlaski, and Sander W.
    Keemink. “Nonlinear Computations in Spiking Neural Networks through Multiplicative
    Synapses.” <i>Peer Community Journal</i>. Centre Mersenne ; Peer Community In,
    2021. <a href="https://doi.org/10.24072/pcjournal.69">https://doi.org/10.24072/pcjournal.69</a>.
  ieee: M. Nardin, J. W. Phillips, W. F. Podlaski, and S. W. Keemink, “Nonlinear computations
    in spiking neural networks through multiplicative synapses,” <i>Peer Community
    Journal</i>, vol. 1. Centre Mersenne ; Peer Community In, 2021.
  ista: Nardin M, Phillips JW, Podlaski WF, Keemink SW. 2021. Nonlinear computations
    in spiking neural networks through multiplicative synapses. Peer Community Journal.
    1, e68.
  mla: Nardin, Michele, et al. “Nonlinear Computations in Spiking Neural Networks
    through Multiplicative Synapses.” <i>Peer Community Journal</i>, vol. 1, e68,
    Centre Mersenne ; Peer Community In, 2021, doi:<a href="https://doi.org/10.24072/pcjournal.69">10.24072/pcjournal.69</a>.
  short: M. Nardin, J.W. Phillips, W.F. Podlaski, S.W. Keemink, Peer Community Journal
    1 (2021).
date_created: 2022-01-17T11:12:40Z
date_published: 2021-12-15T00:00:00Z
date_updated: 2022-01-17T13:30:01Z
day: '15'
ddc:
- '519'
department:
- _id: GradSch
- _id: JoCs
doi: 10.24072/pcjournal.69
ec_funded: 1
external_id:
  arxiv:
  - '2009.03857'
file:
- access_level: open_access
  checksum: cd9af6b331918608f2e3d1c7940cbf4f
  content_type: application/pdf
  creator: mnardin
  date_created: 2022-01-17T11:15:26Z
  date_updated: 2022-01-17T11:15:26Z
  file_id: '10636'
  file_name: 10_24072_pcjournal_69.pdf
  file_size: 3311494
  relation: main_file
  success: 1
file_date_updated: 2022-01-17T11:15:26Z
has_accepted_license: '1'
intvolume: '         1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Peer Community Journal
publication_identifier:
  eissn:
  - 2804-3871
publication_status: published
publisher: Centre Mersenne ; Peer Community In
quality_controlled: '1'
status: public
title: Nonlinear computations in spiking neural networks through multiplicative synapses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 1
year: '2021'
...
---
_id: '10644'
abstract:
- lang: eng
  text: The purpose of this application note is to demonstrate a working example of
    a superconducting qubit measurement in a Bluefors cryostat using the Keysight
    quantum control hardware. Our motivation is twofold. First, we provide pre-qualification
    data that the Bluefors cryostat, including filtering and wiring, can support long-lived
    qubits. Second, we demonstrate that the Keysight system (controlled using Labber)
    provides a straightforward solution to perform these characterization measurements.
    This document is intended as a brief guide for starting an experimental platform
    for testing superconducting qubits. The setup described here is an immediate jumping
    off point for a suite of applications including testing quantum logical gates,
    quantum optics with microwaves, or even using the qubit itself as a sensitive
    probe of local electromagnetic fields. Qubit measurements rely on high performance
    of both the physical sample environment and the measurement electronics. An overview
    of the cryogenic system is shown in Figure 1, and an overview of the integration
    between the electronics and cryostat (including wiring details) is shown in Figure
    2.
alternative_title:
- Bluefors Blog
article_processing_charge: No
author:
- first_name: Russell
  full_name: Lake, Russell
  last_name: Lake
- first_name: Slawomir
  full_name: Simbierowicz, Slawomir
  last_name: Simbierowicz
- first_name: Philip
  full_name: Krantz, Philip
  last_name: Krantz
- first_name: Farid
  full_name: Hassani, Farid
  id: 2AED110C-F248-11E8-B48F-1D18A9856A87
  last_name: Hassani
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: 'Lake R, Simbierowicz S, Krantz P, Hassani F, Fink JM. <i>The Bluefors Dilution
    Refrigerator as an Integrated Quantum Measurement System</i>. Helsinki, Finland:
    Bluefors Oy; 2021.'
  apa: 'Lake, R., Simbierowicz, S., Krantz, P., Hassani, F., &#38; Fink, J. M. (2021).
    <i>The Bluefors dilution refrigerator as an integrated quantum measurement system</i>.
    Helsinki, Finland: Bluefors Oy.'
  chicago: 'Lake, Russell, Slawomir Simbierowicz, Philip Krantz, Farid Hassani, and
    Johannes M Fink. <i>The Bluefors Dilution Refrigerator as an Integrated Quantum
    Measurement System</i>. Helsinki, Finland: Bluefors Oy, 2021.'
  ieee: 'R. Lake, S. Simbierowicz, P. Krantz, F. Hassani, and J. M. Fink, <i>The Bluefors
    dilution refrigerator as an integrated quantum measurement system</i>. Helsinki,
    Finland: Bluefors Oy, 2021.'
  ista: 'Lake R, Simbierowicz S, Krantz P, Hassani F, Fink JM. 2021. The Bluefors
    dilution refrigerator as an integrated quantum measurement system, Helsinki, Finland:
    Bluefors Oy, 9p.'
  mla: Lake, Russell, et al. <i>The Bluefors Dilution Refrigerator as an Integrated
    Quantum Measurement System</i>. Bluefors Oy, 2021.
  short: R. Lake, S. Simbierowicz, P. Krantz, F. Hassani, J.M. Fink, The Bluefors
    Dilution Refrigerator as an Integrated Quantum Measurement System, Bluefors Oy,
    Helsinki, Finland, 2021.
date_created: 2022-01-19T08:29:57Z
date_published: 2021-04-20T00:00:00Z
date_updated: 2022-01-19T09:11:33Z
day: '20'
department:
- _id: JoFi
keyword:
- Application note
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://bluefors.com/blog/integrated-quantum-measurement-system/
month: '04'
oa: 1
oa_version: Published Version
page: '9'
place: Helsinki, Finland
publication_status: published
publisher: Bluefors Oy
quality_controlled: '1'
status: public
title: The Bluefors dilution refrigerator as an integrated quantum measurement system
type: other_academic_publication
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10645'
abstract:
- lang: eng
  text: "Superconducting qubits have emerged as a highly versatile and useful platform
    for quantum technological applications [1]. Bluefors and Zurich Instruments have
    supported the growth of this field from the 2010s onwards by providing well-engineered
    and reliable measurement infrastructure [2]– [6]. Having a long and stable qubit
    lifetime is a critical system property. Therefore, considerable effort has already
    gone into measuring qubit energy-relaxation timescales and their fluctuations,
    see Refs. [7]–[10] among others. Accurately extracting the statistics of a quantum
    device requires users to perform time consuming measurements. One measurement
    challenge is that the detection of the state-dependent\r\nresponse of a superconducting
    resonator due to a dispersively-coupled qubit requires an inherently low signal
    level. Consequently, measurements must be performed using a microwave probe that
    contains only a few microwave photons. Improving the signal-to-noise ratio (SNR)
    by using near-quantum limited parametric amplifiers as well as the use of optimized
    signal processing enabled by efficient room temperature instrumentation help to
    reduce measurement time. An empirical observation for fixed frequency transmons
    from recent literature is that as the energy-relaxation time \U0001D447\U0001D4471
    increases, so do its natural temporal fluctuations [7], [10]. This necessitates
    many repeated measurements to understand the statistics (see for example, Ref.
    [10]). In addition, as state-of-the-art qubits increase in lifetime, longer\r\nmeasurement
    times are expected to obtain accurate statistics. As described below, the scaling
    of the widths of the qubit energy-relaxation distributions also reveal clues about
    the origin of the energy-relaxation."
alternative_title:
- Bluefors Blog
article_processing_charge: No
author:
- first_name: Slawomir
  full_name: Simbierowicz, Slawomir
  last_name: Simbierowicz
- first_name: Chunyan
  full_name: Shi, Chunyan
  last_name: Shi
- first_name: Michele
  full_name: Collodo, Michele
  last_name: Collodo
- first_name: Moritz
  full_name: Kirste, Moritz
  last_name: Kirste
- first_name: Farid
  full_name: Hassani, Farid
  id: 2AED110C-F248-11E8-B48F-1D18A9856A87
  last_name: Hassani
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: Jonas
  full_name: Bylander, Jonas
  last_name: Bylander
- first_name: Daniel
  full_name: Perez Lozano, Daniel
  last_name: Perez Lozano
- first_name: Russell
  full_name: Lake, Russell
  last_name: Lake
citation:
  ama: 'Simbierowicz S, Shi C, Collodo M, et al. <i>Qubit Energy-Relaxation Statistics
    in the Bluefors Quantum Measurement System</i>. Helsinki, Finland: Bluefors Oy;
    2021.'
  apa: 'Simbierowicz, S., Shi, C., Collodo, M., Kirste, M., Hassani, F., Fink, J.
    M., … Lake, R. (2021). <i>Qubit energy-relaxation statistics in the Bluefors quantum
    measurement system</i>. Helsinki, Finland: Bluefors Oy.'
  chicago: 'Simbierowicz, Slawomir, Chunyan Shi, Michele Collodo, Moritz Kirste, Farid
    Hassani, Johannes M Fink, Jonas Bylander, Daniel Perez Lozano, and Russell Lake.
    <i>Qubit Energy-Relaxation Statistics in the Bluefors Quantum Measurement System</i>.
    Helsinki, Finland: Bluefors Oy, 2021.'
  ieee: 'S. Simbierowicz <i>et al.</i>, <i>Qubit energy-relaxation statistics in the
    Bluefors quantum measurement system</i>. Helsinki, Finland: Bluefors Oy, 2021.'
  ista: 'Simbierowicz S, Shi C, Collodo M, Kirste M, Hassani F, Fink JM, Bylander
    J, Perez Lozano D, Lake R. 2021. Qubit energy-relaxation statistics in the Bluefors
    quantum measurement system, Helsinki, Finland: Bluefors Oy, 8p.'
  mla: Simbierowicz, Slawomir, et al. <i>Qubit Energy-Relaxation Statistics in the
    Bluefors Quantum Measurement System</i>. Bluefors Oy, 2021.
  short: S. Simbierowicz, C. Shi, M. Collodo, M. Kirste, F. Hassani, J.M. Fink, J.
    Bylander, D. Perez Lozano, R. Lake, Qubit Energy-Relaxation Statistics in the
    Bluefors Quantum Measurement System, Bluefors Oy, Helsinki, Finland, 2021.
date_created: 2022-01-19T08:41:14Z
date_published: 2021-06-03T00:00:00Z
date_updated: 2022-01-19T09:11:39Z
day: '03'
department:
- _id: JoFi
keyword:
- Application note
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://bluefors.com/blog/application-note-qubit-energy-relaxation-statistics-bluefors-quantum-measurement-system/
month: '06'
oa: 1
oa_version: Published Version
page: '8'
place: Helsinki, Finland
publication_status: published
publisher: Bluefors Oy
quality_controlled: '1'
status: public
title: Qubit energy-relaxation statistics in the Bluefors quantum measurement system
type: other_academic_publication
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10655'
abstract:
- lang: eng
  text: "Adeno-associated viruses (AAVs) are widely used to deliver genetic material
    in vivo to distinct cell types such as neurons or glial cells, allowing for targeted
    manipulation. Transduction of microglia is mostly excluded from this strategy,
    likely due to the cells’ heterogeneous state upon environmental changes, which
    makes AAV design challenging. Here, we established the retina as a model system
    for microglial AAV validation and optimization. First, we show that AAV2/6 transduced
    microglia in both synaptic layers, where layer preference corresponds to the intravitreal
    or subretinal delivery method. Surprisingly, we observed significantly enhanced
    microglial transduction during photoreceptor degeneration. Thus, we modified the
    AAV6 capsid to reduce heparin binding by introducing four point mutations (K531E,
    R576Q, K493S, and K459S), resulting in increased microglial transduction in the
    outer plexiform layer. Finally, to improve microglial-specific transduction, we
    validated a Cre-dependent transgene delivery cassette for use in combination with
    the Cx3cr1CreERT2 mouse line. Together, our results provide a foundation for future
    studies optimizing AAV-mediated microglia transduction and highlight that environmental
    conditions influence microglial transduction efficiency.\r\n"
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement no. 715571). The research was supported by the Scientific Service
  Units (SSU) of IST Austria through resources provided by the Bioimaging Facility,
  the Life Science Facility, and the Pre-Clinical Facility, namely Sonja Haslinger
  and Michael Schunn for their animal colony management and support. We would also
  like to thank Chakrabarty Lab for sharing the plasmids for AAV2/6 production. Finally,
  we would like to thank the Siegert team members for discussion about the manuscript.
article_processing_charge: Yes
article_type: original
author:
- first_name: Margaret E
  full_name: Maes, Margaret E
  id: 3838F452-F248-11E8-B48F-1D18A9856A87
  last_name: Maes
  orcid: 0000-0001-9642-1085
- first_name: Gabriele M.
  full_name: Wögenstein, Gabriele M.
  last_name: Wögenstein
- first_name: Gloria
  full_name: Colombo, Gloria
  id: 3483CF6C-F248-11E8-B48F-1D18A9856A87
  last_name: Colombo
  orcid: 0000-0001-9434-8902
- first_name: Raquel
  full_name: Casado Polanco, Raquel
  id: 15240fc1-dbcd-11ea-9d1d-ac5a786425fd
  last_name: Casado Polanco
  orcid: 0000-0001-8293-4568
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
citation:
  ama: Maes ME, Wögenstein GM, Colombo G, Casado Polanco R, Siegert S. Optimizing
    AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor
    degenerative environment. <i>Molecular Therapy - Methods and Clinical Development</i>.
    2021;23:210-224. doi:<a href="https://doi.org/10.1016/j.omtm.2021.09.006">10.1016/j.omtm.2021.09.006</a>
  apa: Maes, M. E., Wögenstein, G. M., Colombo, G., Casado Polanco, R., &#38; Siegert,
    S. (2021). Optimizing AAV2/6 microglial targeting identified enhanced efficiency
    in the photoreceptor degenerative environment. <i>Molecular Therapy - Methods
    and Clinical Development</i>. Elsevier. <a href="https://doi.org/10.1016/j.omtm.2021.09.006">https://doi.org/10.1016/j.omtm.2021.09.006</a>
  chicago: Maes, Margaret E, Gabriele M. Wögenstein, Gloria Colombo, Raquel Casado
    Polanco, and Sandra Siegert. “Optimizing AAV2/6 Microglial Targeting Identified
    Enhanced Efficiency in the Photoreceptor Degenerative Environment.” <i>Molecular
    Therapy - Methods and Clinical Development</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.omtm.2021.09.006">https://doi.org/10.1016/j.omtm.2021.09.006</a>.
  ieee: M. E. Maes, G. M. Wögenstein, G. Colombo, R. Casado Polanco, and S. Siegert,
    “Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the
    photoreceptor degenerative environment,” <i>Molecular Therapy - Methods and Clinical
    Development</i>, vol. 23. Elsevier, pp. 210–224, 2021.
  ista: Maes ME, Wögenstein GM, Colombo G, Casado Polanco R, Siegert S. 2021. Optimizing
    AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor
    degenerative environment. Molecular Therapy - Methods and Clinical Development.
    23, 210–224.
  mla: Maes, Margaret E., et al. “Optimizing AAV2/6 Microglial Targeting Identified
    Enhanced Efficiency in the Photoreceptor Degenerative Environment.” <i>Molecular
    Therapy - Methods and Clinical Development</i>, vol. 23, Elsevier, 2021, pp. 210–24,
    doi:<a href="https://doi.org/10.1016/j.omtm.2021.09.006">10.1016/j.omtm.2021.09.006</a>.
  short: M.E. Maes, G.M. Wögenstein, G. Colombo, R. Casado Polanco, S. Siegert, Molecular
    Therapy - Methods and Clinical Development 23 (2021) 210–224.
date_created: 2022-01-23T23:01:28Z
date_published: 2021-12-10T00:00:00Z
date_updated: 2023-11-16T13:12:03Z
day: '10'
ddc:
- '570'
department:
- _id: SaSi
- _id: SiHi
doi: 10.1016/j.omtm.2021.09.006
ec_funded: 1
external_id:
  isi:
  - '000748748500019'
file:
- access_level: open_access
  checksum: 77dc540e8011c5475031bdf6ccef20a6
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-01-24T07:43:09Z
  date_updated: 2022-01-24T07:43:09Z
  file_id: '10657'
  file_name: 2021_MolTherMethodsClinDev_Maes.pdf
  file_size: 4794147
  relation: main_file
  success: 1
file_date_updated: 2022-01-24T07:43:09Z
has_accepted_license: '1'
intvolume: '        23'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 210-224
project:
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715571'
  name: Microglia action towards neuronal circuit formation and function in health
    and disease
publication: Molecular Therapy - Methods and Clinical Development
publication_identifier:
  eissn:
  - 2329-0501
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the
  photoreceptor degenerative environment
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2021'
...
---
_id: '12076'
abstract:
- lang: eng
  text: We find an asymptotic formula for the number of primitive vectors $(z_1,\ldots,z_4)\in
    (\mathbb{Z}_{\neq 0})^4$ such that $z_1,\ldots, z_4$ are all squareful and bounded
    by $B$, and $z_1+\cdots + z_4 = 0$. Our result agrees in the power of $B$ and
    $\log B$ with the Campana-Manin conjecture of Pieropan, Smeets, Tanimoto and V\'{a}rilly-Alvarado.
article_number: '2104.06966'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alec L
  full_name: Shute, Alec L
  id: 440EB050-F248-11E8-B48F-1D18A9856A87
  last_name: Shute
  orcid: 0000-0002-1812-2810
citation:
  ama: Shute AL. Sums of four squareful numbers. <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2104.06966">10.48550/arXiv.2104.06966</a>
  apa: Shute, A. L. (n.d.). Sums of four squareful numbers. <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2104.06966">https://doi.org/10.48550/arXiv.2104.06966</a>
  chicago: Shute, Alec L. “Sums of Four Squareful Numbers.” <i>ArXiv</i>, n.d. <a
    href="https://doi.org/10.48550/arXiv.2104.06966">https://doi.org/10.48550/arXiv.2104.06966</a>.
  ieee: A. L. Shute, “Sums of four squareful numbers,” <i>arXiv</i>. .
  ista: Shute AL. Sums of four squareful numbers. arXiv, 2104.06966.
  mla: Shute, Alec L. “Sums of Four Squareful Numbers.” <i>ArXiv</i>, 2104.06966,
    doi:<a href="https://doi.org/10.48550/arXiv.2104.06966">10.48550/arXiv.2104.06966</a>.
  short: A.L. Shute, ArXiv (n.d.).
date_created: 2022-09-09T10:42:51Z
date_published: 2021-04-15T00:00:00Z
date_updated: 2023-02-21T16:37:30Z
day: '15'
department:
- _id: TiBr
doi: 10.48550/arXiv.2104.06966
external_id:
  arxiv:
  - '2104.06966'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2104.06966
month: '04'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
related_material:
  record:
  - id: '12072'
    relation: dissertation_contains
    status: public
status: public
title: Sums of four squareful numbers
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '12077'
abstract:
- lang: eng
  text: "We compare the Manin-type conjecture for Campana points recently formulated\r\nby
    Pieropan, Smeets, Tanimoto and V\\'{a}rilly-Alvarado with an alternative\r\nprediction
    of Browning and Van Valckenborgh in the special case of the orbifold\r\n$(\\mathbb{P}^1,D)$,
    where $D =\\frac{1}{2}[0]+\\frac{1}{2}[1]+\\frac{1}{2}[\\infty]$. We find that
    the two predicted leading constants do not agree, and we discuss whether thin
    sets\r\ncould explain this discrepancy. Motivated by this, we provide a counterexample\r\nto
    the Manin-type conjecture for Campana points, by considering orbifolds\r\ncorresponding
    to squareful values of binary quadratic forms."
acknowledgement: The author would like to thank Damaris Schindler and Florian Wilsch
  for their helpful comments on the heights and Tamagawa measures used in Section
  3, together with Marta Pieropan, Sho Tanimoto and Sam Streeter for providing valuable
  feedback on an earlier version of this paper, and Tim Browning for many useful comments
  and discussions during the development of this work. The author is also grateful
  to the anonymous referee for providing many valuable comments and suggestions that
  improved the quality of the paper.
article_number: '2104.14946'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alec L
  full_name: Shute, Alec L
  id: 440EB050-F248-11E8-B48F-1D18A9856A87
  last_name: Shute
  orcid: 0000-0002-1812-2810
citation:
  ama: Shute AL. On the leading constant in the Manin-type conjecture for Campana
    points. <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2104.14946">10.48550/arXiv.2104.14946</a>
  apa: Shute, A. L. (n.d.). On the leading constant in the Manin-type conjecture for
    Campana points. <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2104.14946">https://doi.org/10.48550/arXiv.2104.14946</a>
  chicago: Shute, Alec L. “On the Leading Constant in the Manin-Type Conjecture for
    Campana Points.” <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/arXiv.2104.14946">https://doi.org/10.48550/arXiv.2104.14946</a>.
  ieee: A. L. Shute, “On the leading constant in the Manin-type conjecture for Campana
    points,” <i>arXiv</i>. .
  ista: Shute AL. On the leading constant in the Manin-type conjecture for Campana
    points. arXiv, 2104.14946.
  mla: Shute, Alec L. “On the Leading Constant in the Manin-Type Conjecture for Campana
    Points.” <i>ArXiv</i>, 2104.14946, doi:<a href="https://doi.org/10.48550/arXiv.2104.14946">10.48550/arXiv.2104.14946</a>.
  short: A.L. Shute, ArXiv (n.d.).
date_created: 2022-09-09T10:43:17Z
date_published: 2021-04-30T00:00:00Z
date_updated: 2023-02-21T16:37:30Z
day: '30'
department:
- _id: TiBr
doi: 10.48550/arXiv.2104.14946
external_id:
  arxiv:
  - '2104.14946'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2104.14946
month: '04'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
related_material:
  record:
  - id: '12072'
    relation: dissertation_contains
    status: public
status: public
title: On the leading constant in the Manin-type conjecture for Campana points
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '12186'
abstract:
- lang: eng
  text: Activation of cell-surface and intracellular receptor-mediated immunity results
    in rapid transcriptional reprogramming that underpins disease resistance. However,
    the mechanisms by which co-activation of both immune systems lead to transcriptional
    changes are not clear. Here, we combine RNA-seq and ATAC-seq to define changes
    in gene expression and chromatin accessibility. Activation of cell-surface or
    intracellular receptor-mediated immunity, or both, increases chromatin accessibility
    at induced defence genes. Analysis of ATAC-seq and RNA-seq data combined with
    publicly available information on transcription factor DNA-binding motifs enabled
    comparison of individual gene regulatory networks activated by cell-surface or
    intracellular receptor-mediated immunity, or by both. These results and analyses
    reveal overlapping and conserved transcriptional regulatory mechanisms between
    the two immune systems.
acknowledgement: "We thank the Gatsby Foundation (UK) for funding to the JDGJ laboratory.
  PD acknowledges support from the European Union’s Horizon 2020 Research and Innovation
  Program under Marie Skłodowska Curie Actions (grant agreement: 656243) and a Future
  Leader Fellowship from the Biotechnology and Biological Sciences Research Council
  (BBSRC) (grant agreement: BB/R012172/1). TS, RKS, DM, and JDGJ were supported by
  the Gatsby Foundation funding to the\r\nSainsbury Laboratory. NMP and KV were supported
  by a BOF grant from Ghent University (grant agreement: BOF24Y2019001901). WG and
  RZ were supported by the Scottish Government Rural and Environment Science and Analytical
  Services division (RESAS), and RZ also acknowledges the support from a BBSRC Bioinformatics
  and Biological Resources Fund (grant agreement: BB/S020160/1).BPMN was supported
  by the Norwich Research Park (NRP) Biosciences Doctoral Training Partnership (DTP)
  funded by the BBSRC (grant agreement: BB/M011216/1). SH and XF were supported by
  a BBSRC Responsive Mode grant (grant agreement: BB/S009620/1) and a European Research
  Council Starting grant ‘SexMeth’ (grant agreement: 804981). CL was supported by
  Deutsche Forschungsgemeinschaft (grant agreement: LI 2862/4). "
article_processing_charge: No
article_type: original
author:
- first_name: Pingtao
  full_name: Ding, Pingtao
  last_name: Ding
- first_name: Toshiyuki
  full_name: Sakai, Toshiyuki
  last_name: Sakai
- first_name: Ram
  full_name: Krishna Shrestha, Ram
  last_name: Krishna Shrestha
- first_name: Nicolas
  full_name: Manosalva Perez, Nicolas
  last_name: Manosalva Perez
- first_name: Wenbin
  full_name: Guo, Wenbin
  last_name: Guo
- first_name: Bruno Pok Man
  full_name: Ngou, Bruno Pok Man
  last_name: Ngou
- first_name: Shengbo
  full_name: He, Shengbo
  last_name: He
- first_name: Chang
  full_name: Liu, Chang
  last_name: Liu
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
- first_name: Runxuan
  full_name: Zhang, Runxuan
  last_name: Zhang
- first_name: Klaas
  full_name: Vandepoele, Klaas
  last_name: Vandepoele
- first_name: Dan
  full_name: MacLean, Dan
  last_name: MacLean
- first_name: Jonathan D G
  full_name: Jones, Jonathan D G
  last_name: Jones
citation:
  ama: Ding P, Sakai T, Krishna Shrestha R, et al. Chromatin accessibility landscapes
    activated by cell-surface and intracellular immune receptors. <i>Journal of Experimental
    Botany</i>. 2021;72(22):7927-7941. doi:<a href="https://doi.org/10.1093/jxb/erab373">10.1093/jxb/erab373</a>
  apa: Ding, P., Sakai, T., Krishna Shrestha, R., Manosalva Perez, N., Guo, W., Ngou,
    B. P. M., … Jones, J. D. G. (2021). Chromatin accessibility landscapes activated
    by cell-surface and intracellular immune receptors. <i>Journal of Experimental
    Botany</i>. Oxford University Press. <a href="https://doi.org/10.1093/jxb/erab373">https://doi.org/10.1093/jxb/erab373</a>
  chicago: Ding, Pingtao, Toshiyuki Sakai, Ram Krishna Shrestha, Nicolas Manosalva
    Perez, Wenbin Guo, Bruno Pok Man Ngou, Shengbo He, et al. “Chromatin Accessibility
    Landscapes Activated by Cell-Surface and Intracellular Immune Receptors.” <i>Journal
    of Experimental Botany</i>. Oxford University Press, 2021. <a href="https://doi.org/10.1093/jxb/erab373">https://doi.org/10.1093/jxb/erab373</a>.
  ieee: P. Ding <i>et al.</i>, “Chromatin accessibility landscapes activated by cell-surface
    and intracellular immune receptors,” <i>Journal of Experimental Botany</i>, vol.
    72, no. 22. Oxford University Press, pp. 7927–7941, 2021.
  ista: Ding P, Sakai T, Krishna Shrestha R, Manosalva Perez N, Guo W, Ngou BPM, He
    S, Liu C, Feng X, Zhang R, Vandepoele K, MacLean D, Jones JDG. 2021. Chromatin
    accessibility landscapes activated by cell-surface and intracellular immune receptors.
    Journal of Experimental Botany. 72(22), 7927–7941.
  mla: Ding, Pingtao, et al. “Chromatin Accessibility Landscapes Activated by Cell-Surface
    and Intracellular Immune Receptors.” <i>Journal of Experimental Botany</i>, vol.
    72, no. 22, Oxford University Press, 2021, pp. 7927–41, doi:<a href="https://doi.org/10.1093/jxb/erab373">10.1093/jxb/erab373</a>.
  short: P. Ding, T. Sakai, R. Krishna Shrestha, N. Manosalva Perez, W. Guo, B.P.M.
    Ngou, S. He, C. Liu, X. Feng, R. Zhang, K. Vandepoele, D. MacLean, J.D.G. Jones,
    Journal of Experimental Botany 72 (2021) 7927–7941.
date_created: 2023-01-16T09:14:35Z
date_published: 2021-08-13T00:00:00Z
date_updated: 2023-05-08T11:01:18Z
day: '13'
department:
- _id: XiFe
doi: 10.1093/jxb/erab373
extern: '1'
external_id:
  pmid:
  - '34387350'
intvolume: '        72'
issue: '22'
keyword:
- Plant Science
- Physiology
language:
- iso: eng
month: '08'
oa_version: None
page: 7927-7941
pmid: 1
publication: Journal of Experimental Botany
publication_identifier:
  issn:
  - 0022-0957
  - 1460-2431
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chromatin accessibility landscapes activated by cell-surface and intracellular
  immune receptors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 72
year: '2021'
...
---
_id: '12187'
abstract:
- lang: eng
  text: Genomes of germ cells present an existential vulnerability to organisms because
    germ cell mutations will propagate to future generations. Transposable elements
    are one source of such mutations. In the small flowering plant Arabidopsis, Long
    et al. found that genome methylation in the male germline is directed by small
    interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective
    by Mosher). These germline siRNAs silence germline transposons and establish inherited
    methylation patterns in sperm, thus maintaining the integrity of the plant genome
    across generations.
acknowledgement: 'We thank the John Innes Centre Bioimaging Facility (S. Lopez, E.
  Wegel, and K. Findlay) for their assistance with microscopy and the Norwich BioScience
  Institute Partnership Computing Infrastructure for Science Group for high-performance
  computing resources. Funding: This work was funded by a European Research Council
  Starting Grant (“SexMeth” 804981; J.L., J.W., and X.F.), a Sainsbury Charitable
  Foundation studentship (J.W.), two Biotechnology and Biological Sciences Research
  Council (BBSRC) grants (BBS0096201 and BBP0135111; W.S., M.V., and X.F.), two John
  Innes Foundation studentships (B.A. and S.D.), and a BBSRC David Phillips Fellowship
  (BBL0250431; H.G. and X.F.). Author contributions: J.L., J.W., and X.F. designed
  the study and wrote the manuscript; J.L., W.S., B.A., H.G., and S.D. performed the
  experiments; and J.L., J.W., B.A., H.G., S.D., M.V., and X.F. analyzed the data.
  Competing interests: The authors declare no competing interests. Data and material
  availability: All sequencing data have been deposited in the Gene Expression Omnibus
  (GEO) under accession no. GSE161625. Accession nos. of published datasets used in
  this study are listed in table S6. Published software used in this study include
  Bowtie v1.2.2 (https://doi.org/10.1002/0471250953.bi1107s32), Bismark v0.22.2 (https://doi.org/10.1093/bioinformatics/btr167),
  Kallisto v0.43.0 (https://doi.org/10.1038/nbt0816-888d), Shortstack v3.8.5 (https://doi.org/10.1534/g3.116.030452),
  and Cutadapt v1.15 (https://doi.org/10.1089/cmb.2017.0096). TrimGalore v0.4.1 and
  MarkDuplicates v1.141 are available from https://github.com/FelixKrueger/TrimGalore
  and https://github.com/broadinstitute/picard, respectively. All remaining data are
  in the main paper or the supplementary materials.'
article_processing_charge: No
article_type: original
author:
- first_name: Jincheng
  full_name: Long, Jincheng
  last_name: Long
- first_name: James
  full_name: Walker, James
  last_name: Walker
- first_name: Wenjing
  full_name: She, Wenjing
  last_name: She
- first_name: Billy
  full_name: Aldridge, Billy
  last_name: Aldridge
- first_name: Hongbo
  full_name: Gao, Hongbo
  last_name: Gao
- first_name: Samuel
  full_name: Deans, Samuel
  last_name: Deans
- first_name: Martin
  full_name: Vickers, Martin
  last_name: Vickers
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
citation:
  ama: Long J, Walker J, She W, et al. Nurse cell--derived small RNAs define paternal
    epigenetic inheritance in Arabidopsis. <i>Science</i>. 2021;373(6550). doi:<a
    href="https://doi.org/10.1126/science.abh0556">10.1126/science.abh0556</a>
  apa: Long, J., Walker, J., She, W., Aldridge, B., Gao, H., Deans, S., … Feng, X.
    (2021). Nurse cell--derived small RNAs define paternal epigenetic inheritance
    in Arabidopsis. <i>Science</i>. American Association for the Advancement of Science
    (AAAS). <a href="https://doi.org/10.1126/science.abh0556">https://doi.org/10.1126/science.abh0556</a>
  chicago: Long, Jincheng, James Walker, Wenjing She, Billy Aldridge, Hongbo Gao,
    Samuel Deans, Martin Vickers, and Xiaoqi Feng. “Nurse Cell--Derived Small RNAs
    Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>. American
    Association for the Advancement of Science (AAAS), 2021. <a href="https://doi.org/10.1126/science.abh0556">https://doi.org/10.1126/science.abh0556</a>.
  ieee: J. Long <i>et al.</i>, “Nurse cell--derived small RNAs define paternal epigenetic
    inheritance in Arabidopsis,” <i>Science</i>, vol. 373, no. 6550. American Association
    for the Advancement of Science (AAAS), 2021.
  ista: Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Vickers M, Feng X. 2021.
    Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis.
    Science. 373(6550).
  mla: Long, Jincheng, et al. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic
    Inheritance in Arabidopsis.” <i>Science</i>, vol. 373, no. 6550, American Association
    for the Advancement of Science (AAAS), 2021, doi:<a href="https://doi.org/10.1126/science.abh0556">10.1126/science.abh0556</a>.
  short: J. Long, J. Walker, W. She, B. Aldridge, H. Gao, S. Deans, M. Vickers, X.
    Feng, Science 373 (2021).
date_created: 2023-01-16T09:15:14Z
date_published: 2021-07-02T00:00:00Z
date_updated: 2023-05-08T10:56:39Z
day: '02'
department:
- _id: XiFe
doi: 10.1126/science.abh0556
extern: '1'
external_id:
  pmid:
  - '34210850'
intvolume: '       373'
issue: '6550'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '07'
oa_version: None
pmid: 1
publication: Science
publication_identifier:
  issn:
  - 0036-8075
  - 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science (AAAS)
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 373
year: '2021'
...
---
_id: '12767'
abstract:
- lang: eng
  text: "Several problems in planning and reactive synthesis can be reduced to the
    analysis of two-player quantitative graph games. Optimization is one form of analysis.
    We argue that in many cases it may be better to replace the optimization problem
    with the satisficing problem, where instead of searching for optimal solutions,
    the goal is to search for solutions that adhere to a given threshold bound.\r\nThis
    work defines and investigates the satisficing problem on a two-player graph game
    with the discounted-sum cost model. We show that while the satisficing problem
    can be solved using numerical methods just like the optimization problem, this
    approach does not render compelling benefits over optimization. When the discount
    factor is, however, an integer, we present another approach to satisficing, which
    is purely based on automata methods. We show that this approach is algorithmically
    more performant – both theoretically and empirically – and demonstrates the broader
    applicability of satisficing over optimization."
acknowledgement: We thank anonymous reviewers for valuable inputs. This work is supported
  in part by NSF grant 2030859 to the CRA for the CIFellows Project, NSF grants IIS-1527668,
  CCF-1704883, IIS-1830549, the ERC CoG 863818 (ForM-SMArt), and an award from the
  Maryland Procurement Office.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Suguman
  full_name: Bansal, Suguman
  last_name: Bansal
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Moshe Y.
  full_name: Vardi, Moshe Y.
  last_name: Vardi
citation:
  ama: 'Bansal S, Chatterjee K, Vardi MY. On satisficing in quantitative games. In:
    <i>27th International Conference on Tools and Algorithms for the Construction
    and Analysis of Systems</i>. Vol 12651. Springer Nature; 2021:20-37. doi:<a href="https://doi.org/10.1007/978-3-030-72016-2">10.1007/978-3-030-72016-2</a>'
  apa: 'Bansal, S., Chatterjee, K., &#38; Vardi, M. Y. (2021). On satisficing in quantitative
    games. In <i>27th International Conference on Tools and Algorithms for the Construction
    and Analysis of Systems</i> (Vol. 12651, pp. 20–37). Luxembourg City, Luxembourg:
    Springer Nature. <a href="https://doi.org/10.1007/978-3-030-72016-2">https://doi.org/10.1007/978-3-030-72016-2</a>'
  chicago: Bansal, Suguman, Krishnendu Chatterjee, and Moshe Y. Vardi. “On Satisficing
    in Quantitative Games.” In <i>27th International Conference on Tools and Algorithms
    for the Construction and Analysis of Systems</i>, 12651:20–37. Springer Nature,
    2021. <a href="https://doi.org/10.1007/978-3-030-72016-2">https://doi.org/10.1007/978-3-030-72016-2</a>.
  ieee: S. Bansal, K. Chatterjee, and M. Y. Vardi, “On satisficing in quantitative
    games,” in <i>27th International Conference on Tools and Algorithms for the Construction
    and Analysis of Systems</i>, Luxembourg City, Luxembourg, 2021, vol. 12651, pp.
    20–37.
  ista: 'Bansal S, Chatterjee K, Vardi MY. 2021. On satisficing in quantitative games.
    27th International Conference on Tools and Algorithms for the Construction and
    Analysis of Systems. TACAS: Tools and Algorithms for the Construction and Analysis
    of Systems, LNCS, vol. 12651, 20–37.'
  mla: Bansal, Suguman, et al. “On Satisficing in Quantitative Games.” <i>27th International
    Conference on Tools and Algorithms for the Construction and Analysis of Systems</i>,
    vol. 12651, Springer Nature, 2021, pp. 20–37, doi:<a href="https://doi.org/10.1007/978-3-030-72016-2">10.1007/978-3-030-72016-2</a>.
  short: S. Bansal, K. Chatterjee, M.Y. Vardi, in:, 27th International Conference
    on Tools and Algorithms for the Construction and Analysis of Systems, Springer
    Nature, 2021, pp. 20–37.
conference:
  end_date: 2021-04-01
  location: Luxembourg City, Luxembourg
  name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
  start_date: 2021-03-27
date_created: 2023-03-26T22:01:09Z
date_published: 2021-03-21T00:00:00Z
date_updated: 2025-07-14T09:09:51Z
day: '21'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/978-3-030-72016-2
ec_funded: 1
external_id:
  arxiv:
  - '2101.02594'
file:
- access_level: open_access
  checksum: b020b78b23587ce7610b1aafb4e63438
  content_type: application/pdf
  creator: dernst
  date_created: 2023-03-28T11:00:33Z
  date_updated: 2023-03-28T11:00:33Z
  file_id: '12777'
  file_name: 2021_LNCS_Bansal.pdf
  file_size: 747418
  relation: main_file
  success: 1
file_date_updated: 2023-03-28T11:00:33Z
has_accepted_license: '1'
intvolume: '     12651'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 20-37
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: 27th International Conference on Tools and Algorithms for the Construction
  and Analysis of Systems
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783030720155'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On satisficing in quantitative games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12651
year: '2021'
...
---
_id: '12909'
article_processing_charge: No
author:
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Stefano
  full_name: Elefante, Stefano
  id: 490F40CE-F248-11E8-B48F-1D18A9856A87
  last_name: Elefante
- first_name: Andrei
  full_name: Hornoiu, Andrei
  id: 77129392-B450-11EA-8745-D4653DDC885E
  last_name: Hornoiu
- first_name: Stephan
  full_name: Stadlbauer, Stephan
  id: 4D0BC184-F248-11E8-B48F-1D18A9856A87
  last_name: Stadlbauer
citation:
  ama: 'Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. Managing software on a heterogenous
    HPC cluster. In: <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>. University
    of Ljubljana; 2021:5. doi:<a href="https://doi.org/10.3359/2021hpc">10.3359/2021hpc</a>'
  apa: 'Schlögl, A., Elefante, S., Hornoiu, A., &#38; Stadlbauer, S. (2021). Managing
    software on a heterogenous HPC cluster. In <i>ASHPC21 – Austrian-Slovenian HPC
    Meeting 2021</i> (p. 5). Virtual: University of Ljubljana. <a href="https://doi.org/10.3359/2021hpc">https://doi.org/10.3359/2021hpc</a>'
  chicago: Schlögl, Alois, Stefano Elefante, Andrei Hornoiu, and Stephan Stadlbauer.
    “Managing Software on a Heterogenous HPC Cluster.” In <i>ASHPC21 – Austrian-Slovenian
    HPC Meeting 2021</i>, 5. University of Ljubljana, 2021. <a href="https://doi.org/10.3359/2021hpc">https://doi.org/10.3359/2021hpc</a>.
  ieee: A. Schlögl, S. Elefante, A. Hornoiu, and S. Stadlbauer, “Managing software
    on a heterogenous HPC cluster,” in <i>ASHPC21 – Austrian-Slovenian HPC Meeting
    2021</i>, Virtual, 2021, p. 5.
  ista: Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. 2021. Managing software on
    a heterogenous HPC cluster. ASHPC21 – Austrian-Slovenian HPC Meeting 2021. ASHPC
    - Austrian-Slovenian HPC Meeting, 5.
  mla: Schlögl, Alois, et al. “Managing Software on a Heterogenous HPC Cluster.” <i>ASHPC21
    – Austrian-Slovenian HPC Meeting 2021</i>, University of Ljubljana, 2021, p. 5,
    doi:<a href="https://doi.org/10.3359/2021hpc">10.3359/2021hpc</a>.
  short: A. Schlögl, S. Elefante, A. Hornoiu, S. Stadlbauer, in:, ASHPC21 – Austrian-Slovenian
    HPC Meeting 2021, University of Ljubljana, 2021, p. 5.
conference:
  end_date: 2021-06-02
  location: Virtual
  name: ASHPC - Austrian-Slovenian HPC Meeting
  start_date: 2021-05-31
date_created: 2023-05-05T13:17:36Z
date_published: 2021-06-02T00:00:00Z
date_updated: 2023-05-16T07:43:54Z
day: '02'
ddc:
- '000'
department:
- _id: ScienComp
doi: 10.3359/2021hpc
file:
- access_level: open_access
  checksum: ba73f85858fb9d5737ebc7724646dd45
  content_type: application/pdf
  creator: dernst
  date_created: 2023-05-16T07:36:34Z
  date_updated: 2023-05-16T07:36:34Z
  file_id: '12971'
  file_name: 2021_ASHPC_Schloegl.pdf
  file_size: 422761
  relation: main_file
  success: 1
file_date_updated: 2023-05-16T07:36:34Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ashpc21/BOOKLET_ASHPC21.pdf
month: '06'
oa: 1
oa_version: Published Version
page: '5'
publication: ASHPC21 – Austrian-Slovenian HPC Meeting 2021
publication_identifier:
  isbn:
  - 978-961-6980-77-7
  - 978-961-6133-48-7
publication_status: published
publisher: University of Ljubljana
status: public
title: Managing software on a heterogenous HPC cluster
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '12987'
abstract:
- lang: eng
  text: Chromosomal inversion polymorphisms, segments of chromosomes that are flipped
    in orientation and occur in reversed order in some individuals, have long been
    recognized to play an important role in local adaptation. They can reduce recombination
    in heterozygous individuals and thus help to maintain sets of locally adapted
    alleles. In a wide range of organisms, populations adapted to different habitats
    differ in frequency of inversion arrangements. However, getting a full understanding
    of the importance of inversions for adaptation requires confirmation of their
    influence on traits under divergent selection. Here, we studied a marine snail,
    Littorina saxatilis, that has evolved ecotypes adapted to wave exposure or crab
    predation. These two types occur in close proximity on different parts of the
    shore. Gene flow between them exists in contact zones. However, they exhibit strong
    phenotypic divergence in several traits under habitat-specific selection, including
    size, shape and behaviour. We used crosses between these ecotypes to identify
    genomic regions that explain variation in these traits by using QTL analysis and
    variance partitioning across linkage groups. We could show that previously detected
    inversion regions contribute to adaptive divergence. Some inversions influenced
    multiple traits suggesting that they contain sets of locally adaptive alleles.
    Our study also identified regions without known inversions that are important
    for phenotypic divergence. Thus, we provide a more complete overview of the importance
    of inversions in relation to the remaining genome.
article_processing_charge: No
author:
- first_name: Eva
  full_name: Koch, Eva
  last_name: Koch
- first_name: Hernán E.
  full_name: Morales, Hernán E.
  last_name: Morales
- first_name: Jenny
  full_name: Larsson, Jenny
  last_name: Larsson
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
- first_name: Alan R.
  full_name: Lemmon, Alan R.
  last_name: Lemmon
- first_name: E. Moriarty
  full_name: Lemmon, E. Moriarty
  last_name: Lemmon
- first_name: Kerstin
  full_name: Johannesson, Kerstin
  last_name: Johannesson
- first_name: Roger K.
  full_name: Butlin, Roger K.
  last_name: Butlin
citation:
  ama: 'Koch E, Morales HE, Larsson J, et al. Data from: Genetic variation for adaptive
    traits is associated with polymorphic inversions in Littorina saxatilis. 2021.
    doi:<a href="https://doi.org/10.5061/DRYAD.ZGMSBCCB4">10.5061/DRYAD.ZGMSBCCB4</a>'
  apa: 'Koch, E., Morales, H. E., Larsson, J., Westram, A. M., Faria, R., Lemmon,
    A. R., … Butlin, R. K. (2021). Data from: Genetic variation for adaptive traits
    is associated with polymorphic inversions in Littorina saxatilis. Dryad. <a href="https://doi.org/10.5061/DRYAD.ZGMSBCCB4">https://doi.org/10.5061/DRYAD.ZGMSBCCB4</a>'
  chicago: 'Koch, Eva, Hernán E. Morales, Jenny Larsson, Anja M Westram, Rui Faria,
    Alan R. Lemmon, E. Moriarty Lemmon, Kerstin Johannesson, and Roger K. Butlin.
    “Data from: Genetic Variation for Adaptive Traits Is Associated with Polymorphic
    Inversions in Littorina Saxatilis.” Dryad, 2021. <a href="https://doi.org/10.5061/DRYAD.ZGMSBCCB4">https://doi.org/10.5061/DRYAD.ZGMSBCCB4</a>.'
  ieee: 'E. Koch <i>et al.</i>, “Data from: Genetic variation for adaptive traits
    is associated with polymorphic inversions in Littorina saxatilis.” Dryad, 2021.'
  ista: 'Koch E, Morales HE, Larsson J, Westram AM, Faria R, Lemmon AR, Lemmon EM,
    Johannesson K, Butlin RK. 2021. Data from: Genetic variation for adaptive traits
    is associated with polymorphic inversions in Littorina saxatilis, Dryad, <a href="https://doi.org/10.5061/DRYAD.ZGMSBCCB4">10.5061/DRYAD.ZGMSBCCB4</a>.'
  mla: 'Koch, Eva, et al. <i>Data from: Genetic Variation for Adaptive Traits Is Associated
    with Polymorphic Inversions in Littorina Saxatilis</i>. Dryad, 2021, doi:<a href="https://doi.org/10.5061/DRYAD.ZGMSBCCB4">10.5061/DRYAD.ZGMSBCCB4</a>.'
  short: E. Koch, H.E. Morales, J. Larsson, A.M. Westram, R. Faria, A.R. Lemmon, E.M.
    Lemmon, K. Johannesson, R.K. Butlin, (2021).
date_created: 2023-05-16T12:34:09Z
date_published: 2021-04-10T00:00:00Z
date_updated: 2023-08-08T13:34:07Z
day: '10'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5061/DRYAD.ZGMSBCCB4
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.zgmsbccb4
month: '04'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '9394'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Genetic variation for adaptive traits is associated with polymorphic
  inversions in Littorina saxatilis'
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9728'
abstract:
- lang: eng
  text: "Most real-world flows are multiphase, yet we know little about them compared
    to their single-phase counterparts. Multiphase flows are more difficult to investigate
    as their dynamics occur in large parameter space and involve complex phenomena
    such as preferential concentration, turbulence modulation, non-Newtonian rheology,
    etc. Over the last few decades, experiments in particle-laden flows have taken
    a back seat in favour of ever-improving computational resources. However, computers
    are still not powerful enough to simulate a real-world fluid with millions of
    finite-size particles. Experiments are essential not only because they offer a
    reliable way to investigate real-world multiphase flows but also because they
    serve to validate numerical studies and steer the research in a relevant direction.
    In this work, we have experimentally investigated particle-laden flows in pipes,
    and in particular, examined the effect of particles on the laminar-turbulent transition
    and the drag scaling in turbulent flows.\r\n\r\nFor particle-laden pipe flows,
    an earlier study [Matas et al., 2003] reported how the sub-critical (i.e., hysteretic)
    transition that occurs via localised turbulent structures called puffs is affected
    by the addition of particles. In this study, in addition to this known transition,
    we found a super-critical transition to a globally fluctuating state with increasing
    particle concentration. At the same time, the Newtonian-type transition via puffs
    is delayed to larger Reynolds numbers. At an even higher concentration, only the
    globally fluctuating state is found. The dynamics of particle-laden flows are
    hence determined by two competing instabilities that give rise to three flow regimes:
    Newtonian-type turbulence at low, a particle-induced globally fluctuating state
    at high, and a coexistence state at intermediate concentrations.\r\n\r\nThe effect
    of particles on turbulent drag is ambiguous, with studies reporting drag reduction,
    no net change, and even drag increase. The ambiguity arises because, in addition
    to particle concentration, particle shape, size, and density also affect the net
    drag. Even similar particles might affect the flow dissimilarly in different Reynolds
    number and concentration ranges. In the present study, we explored a wide range
    of both Reynolds number and concentration, using spherical as well as cylindrical
    particles. We found that the spherical particles do not reduce drag while the
    cylindrical particles are drag-reducing within a specific Reynolds number interval.
    The interval strongly depends on the particle concentration and the relative size
    of the pipe and particles. Within this interval, the magnitude of drag reduction
    reaches a maximum. These drag reduction maxima appear to fall onto a distinct
    power-law curve irrespective of the pipe diameter and particle concentration,
    and this curve can be considered as the maximum drag reduction asymptote for a
    given fibre shape. Such an asymptote is well known for polymeric flows but had
    not been identified for particle-laden flows prior to this work."
acknowledged_ssus:
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nishchal
  full_name: Agrawal, Nishchal
  id: 469E6004-F248-11E8-B48F-1D18A9856A87
  last_name: Agrawal
citation:
  ama: Agrawal N. Transition to turbulence and drag reduction in particle-laden pipe
    flows. 2021. doi:<a href="https://doi.org/10.15479/at:ista:9728">10.15479/at:ista:9728</a>
  apa: Agrawal, N. (2021). <i>Transition to turbulence and drag reduction in particle-laden
    pipe flows</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:9728">https://doi.org/10.15479/at:ista:9728</a>
  chicago: Agrawal, Nishchal. “Transition to Turbulence and Drag Reduction in Particle-Laden
    Pipe Flows.” Institute of Science and Technology Austria, 2021. <a href="https://doi.org/10.15479/at:ista:9728">https://doi.org/10.15479/at:ista:9728</a>.
  ieee: N. Agrawal, “Transition to turbulence and drag reduction in particle-laden
    pipe flows,” Institute of Science and Technology Austria, 2021.
  ista: Agrawal N. 2021. Transition to turbulence and drag reduction in particle-laden
    pipe flows. Institute of Science and Technology Austria.
  mla: Agrawal, Nishchal. <i>Transition to Turbulence and Drag Reduction in Particle-Laden
    Pipe Flows</i>. Institute of Science and Technology Austria, 2021, doi:<a href="https://doi.org/10.15479/at:ista:9728">10.15479/at:ista:9728</a>.
  short: N. Agrawal, Transition to Turbulence and Drag Reduction in Particle-Laden
    Pipe Flows, Institute of Science and Technology Austria, 2021.
date_created: 2021-07-27T13:40:30Z
date_published: 2021-07-29T00:00:00Z
date_updated: 2024-02-28T13:14:39Z
day: '29'
ddc:
- '532'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BjHo
doi: 10.15479/at:ista:9728
file:
- access_level: closed
  checksum: 77436be3563a90435024307b1b5ee7e8
  content_type: application/x-zip-compressed
  creator: nagrawal
  date_created: 2021-07-28T13:32:02Z
  date_updated: 2022-07-29T22:30:05Z
  embargo_to: open_access
  file_id: '9744'
  file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.zip
  file_size: 22859658
  relation: source_file
- access_level: open_access
  checksum: 72a891d7daba85445c29b868c22575ed
  content_type: application/pdf
  creator: nagrawal
  date_created: 2021-07-28T13:32:05Z
  date_updated: 2022-07-29T22:30:05Z
  embargo: 2022-07-28
  file_id: '9745'
  file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.pdf
  file_size: 18658048
  relation: main_file
file_date_updated: 2022-07-29T22:30:05Z
has_accepted_license: '1'
keyword:
- Drag Reduction
- Transition to Turbulence
- Multiphase Flows
- particle Laden Flows
- Complex Flows
- Experiments
- Fluid Dynamics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '118'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6189'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
title: Transition to turbulence and drag reduction in particle-laden pipe flows
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9733'
abstract:
- lang: eng
  text: This thesis is the result of the research carried out by the author during
    his PhD at IST Austria between 2017 and 2021. It mainly focuses on the Fröhlich
    polaron model, specifically to its regime of strong coupling. This model, which
    is rigorously introduced and discussed in the introduction, has been of great
    interest in condensed matter physics and field theory for more than eighty years.
    It is used to describe an electron interacting with the atoms of a solid material
    (the strength of this interaction is modeled by the presence of a coupling constant
    α in the Hamiltonian of the system). The particular regime examined here, which
    is mathematically described by considering the limit α →∞, displays many interesting
    features related to the emergence of classical behavior, which allows for a simplified
    effective description of the system under analysis. The properties, the range
    of validity and a quantitative analysis of the precision of such classical approximations
    are the main object of the present work. We specify our investigation to the study
    of the ground state energy of the system, its dynamics and its effective mass.
    For each of these problems, we provide in the introduction an overview of the
    previously known results and a detailed account of the original contributions
    by the author.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dario
  full_name: Feliciangeli, Dario
  id: 41A639AA-F248-11E8-B48F-1D18A9856A87
  last_name: Feliciangeli
  orcid: 0000-0003-0754-8530
citation:
  ama: Feliciangeli D. The polaron at strong coupling. 2021. doi:<a href="https://doi.org/10.15479/at:ista:9733">10.15479/at:ista:9733</a>
  apa: Feliciangeli, D. (2021). <i>The polaron at strong coupling</i>. Institute of
    Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:9733">https://doi.org/10.15479/at:ista:9733</a>
  chicago: Feliciangeli, Dario. “The Polaron at Strong Coupling.” Institute of Science
    and Technology Austria, 2021. <a href="https://doi.org/10.15479/at:ista:9733">https://doi.org/10.15479/at:ista:9733</a>.
  ieee: D. Feliciangeli, “The polaron at strong coupling,” Institute of Science and
    Technology Austria, 2021.
  ista: Feliciangeli D. 2021. The polaron at strong coupling. Institute of Science
    and Technology Austria.
  mla: Feliciangeli, Dario. <i>The Polaron at Strong Coupling</i>. Institute of Science
    and Technology Austria, 2021, doi:<a href="https://doi.org/10.15479/at:ista:9733">10.15479/at:ista:9733</a>.
  short: D. Feliciangeli, The Polaron at Strong Coupling, Institute of Science and
    Technology Austria, 2021.
date_created: 2021-07-27T15:48:30Z
date_published: 2021-08-20T00:00:00Z
date_updated: 2024-03-06T12:30:44Z
day: '20'
ddc:
- '515'
- '519'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
- _id: JaMa
doi: 10.15479/at:ista:9733
ec_funded: 1
file:
- access_level: open_access
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has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '180'
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '716117'
  name: Optimal Transport and Stochastic Dynamics
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
  grant_number: F6504
  name: Taming Complexity in Partial Differential Systems
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '9787'
    relation: part_of_dissertation
    status: public
  - id: '9792'
    relation: part_of_dissertation
    status: public
  - id: '9225'
    relation: part_of_dissertation
    status: public
  - id: '9781'
    relation: part_of_dissertation
    status: public
  - id: '9791'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Jan
  full_name: Maas, Jan
  id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
  last_name: Maas
  orcid: 0000-0002-0845-1338
title: The polaron at strong coupling
tmp:
  image: /image/cc_by_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
  name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
  short: CC BY-ND (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9746'
abstract:
- lang: eng
  text: Evolutionary adaptation is a major source of antibiotic resistance in bacterial
    pathogens. Evolution-informed therapy aims to constrain resistance by accounting
    for bacterial evolvability. Sequential treatments with antibiotics that target
    different bacterial processes were previously shown to limit adaptation through
    genetic resistance trade-offs and negative hysteresis. Treatment with homogeneous
    sets of antibiotics is generally viewed to be disadvantageous, as it should rapidly
    lead to cross-resistance. We here challenged this assumption by determining the
    evolutionary response of Pseudomonas aeruginosa to experimental sequential treatments
    involving both heterogenous and homogeneous antibiotic sets. To our surprise,
    we found that fast switching between only β-lactam antibiotics resulted in increased
    extinction of bacterial populations. We demonstrate that extinction is favored
    by low rates of spontaneous resistance emergence and low levels of spontaneous
    cross-resistance among the antibiotics in sequence. The uncovered principles may
    help to guide the optimized use of available antibiotics in highly potent, evolution-informed
    treatment designs.
acknowledgement: We would like to thank Leif Tueffers and João Botelho for discussions
  and suggestions as well as Kira Haas and Julia Bunk for technical support. We acknowledge
  financial support from the German Science Foundation (grant SCHU 1415/12-2 to HS,
  and funding under Germany’s Excellence Strategy EXC 2167–390884018 as well as the
  Research Training Group 2501 TransEvo to HS and SN), the Max Planck Society (IMPRS
  scholarship to AB; Max-Planck fellowship to HS), and the Leibniz Science Campus
  Evolutionary Medicine of the Lung (EvoLUNG, to HS and SN). This work was further
  supported by the German Science Foundation Research Infrastructure NGS_CC (project
  407495230) as part of the Next Generation Sequencing Competence Network (project
  423957469). NGS analyses were carried out at the Competence Centre for Genomic Analysis
  Kiel (CCGA Kiel).
article_number: e68876
article_processing_charge: No
article_type: original
author:
- first_name: Aditi
  full_name: Batra, Aditi
  last_name: Batra
- first_name: Roderich
  full_name: Römhild, Roderich
  id: 68E56E44-62B0-11EA-B963-444F3DDC885E
  last_name: Römhild
  orcid: 0000-0001-9480-5261
- first_name: Emilie
  full_name: Rousseau, Emilie
  last_name: Rousseau
- first_name: Sören
  full_name: Franzenburg, Sören
  last_name: Franzenburg
- first_name: Stefan
  full_name: Niemann, Stefan
  last_name: Niemann
- first_name: Hinrich
  full_name: Schulenburg, Hinrich
  last_name: Schulenburg
citation:
  ama: Batra A, Römhild R, Rousseau E, Franzenburg S, Niemann S, Schulenburg H. High
    potency of sequential therapy with only beta-lactam antibiotics. <i>eLife</i>.
    2021;10. doi:<a href="https://doi.org/10.7554/elife.68876">10.7554/elife.68876</a>
  apa: Batra, A., Römhild, R., Rousseau, E., Franzenburg, S., Niemann, S., &#38; Schulenburg,
    H. (2021). High potency of sequential therapy with only beta-lactam antibiotics.
    <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/elife.68876">https://doi.org/10.7554/elife.68876</a>
  chicago: Batra, Aditi, Roderich Römhild, Emilie Rousseau, Sören Franzenburg, Stefan
    Niemann, and Hinrich Schulenburg. “High Potency of Sequential Therapy with Only
    Beta-Lactam Antibiotics.” <i>ELife</i>. eLife Sciences Publications, 2021. <a
    href="https://doi.org/10.7554/elife.68876">https://doi.org/10.7554/elife.68876</a>.
  ieee: A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, and H. Schulenburg,
    “High potency of sequential therapy with only beta-lactam antibiotics,” <i>eLife</i>,
    vol. 10. eLife Sciences Publications, 2021.
  ista: Batra A, Römhild R, Rousseau E, Franzenburg S, Niemann S, Schulenburg H. 2021.
    High potency of sequential therapy with only beta-lactam antibiotics. eLife. 10,
    e68876.
  mla: Batra, Aditi, et al. “High Potency of Sequential Therapy with Only Beta-Lactam
    Antibiotics.” <i>ELife</i>, vol. 10, e68876, eLife Sciences Publications, 2021,
    doi:<a href="https://doi.org/10.7554/elife.68876">10.7554/elife.68876</a>.
  short: A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, H. Schulenburg,
    ELife 10 (2021).
date_created: 2021-07-28T13:36:57Z
date_published: 2021-07-28T00:00:00Z
date_updated: 2023-08-11T10:26:29Z
day: '28'
department:
- _id: CaGu
doi: 10.7554/elife.68876
external_id:
  isi:
  - '000692027800001'
  pmid:
  - '34318749'
intvolume: '        10'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.7554/eLife.68876
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: High potency of sequential therapy with only beta-lactam antibiotics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '9756'
abstract:
- lang: eng
  text: High-resolution visualization and quantification of membrane proteins contribute
    to the understanding of their functions and the roles they play in physiological
    and pathological conditions. Sodium dodecyl sulfate-digested freeze-fracture replica
    labeling (SDS-FRL) is a powerful electron microscopy method to study quantitatively
    the two-dimensional distribution of transmembrane proteins and their tightly associated
    proteins. During treatment with SDS, intracellular organelles and proteins not
    anchored to the replica are dissolved, whereas integral membrane proteins captured
    and stabilized by carbon/platinum deposition remain on the replica. Their intra-
    and extracellular domains become exposed on the surface of the replica, facilitating
    the accessibility of antibodies and, therefore, providing higher labeling efficiency
    than those obtained with other immunoelectron microscopy techniques. In this chapter,
    we describe the protocols of SDS-FRL adapted for mammalian brain samples, and
    optimization of the SDS treatment to increase the labeling efficiency for quantification
    of Cav2.1, the alpha subunit of P/Q-type voltage-dependent calcium channels utilizing
    deep learning algorithms.
acknowledgement: This work was supported by the European Union (European Research
  Council Advanced grant no. 694539 and Human Brain Project Ref. 720270 to R. S.)
  and the Austrian Academy of Sciences (DOC fellowship to D.K.).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Walter
  full_name: Kaufmann, Walter
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- first_name: David
  full_name: Kleindienst, David
  id: 42E121A4-F248-11E8-B48F-1D18A9856A87
  last_name: Kleindienst
- first_name: Harumi
  full_name: Harada, Harumi
  id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
  last_name: Harada
  orcid: 0000-0001-7429-7896
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: 'Kaufmann W, Kleindienst D, Harada H, Shigemoto R. High-Resolution localization
    and quantitation of membrane proteins by SDS-digested freeze-fracture replica
    labeling (SDS-FRL). In: <i> Receptor and Ion Channel Detection in the Brain</i>.
    Vol 169. Neuromethods. New York: Humana; 2021:267-283. doi:<a href="https://doi.org/10.1007/978-1-0716-1522-5_19">10.1007/978-1-0716-1522-5_19</a>'
  apa: 'Kaufmann, W., Kleindienst, D., Harada, H., &#38; Shigemoto, R. (2021). High-Resolution
    localization and quantitation of membrane proteins by SDS-digested freeze-fracture
    replica labeling (SDS-FRL). In <i> Receptor and Ion Channel Detection in the Brain</i>
    (Vol. 169, pp. 267–283). New York: Humana. <a href="https://doi.org/10.1007/978-1-0716-1522-5_19">https://doi.org/10.1007/978-1-0716-1522-5_19</a>'
  chicago: 'Kaufmann, Walter, David Kleindienst, Harumi Harada, and Ryuichi Shigemoto.
    “High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested
    Freeze-Fracture Replica Labeling (SDS-FRL).” In <i> Receptor and Ion Channel Detection
    in the Brain</i>, 169:267–83. Neuromethods. New York: Humana, 2021. <a href="https://doi.org/10.1007/978-1-0716-1522-5_19">https://doi.org/10.1007/978-1-0716-1522-5_19</a>.'
  ieee: 'W. Kaufmann, D. Kleindienst, H. Harada, and R. Shigemoto, “High-Resolution
    localization and quantitation of membrane proteins by SDS-digested freeze-fracture
    replica labeling (SDS-FRL),” in <i> Receptor and Ion Channel Detection in the
    Brain</i>, vol. 169, New York: Humana, 2021, pp. 267–283.'
  ista: 'Kaufmann W, Kleindienst D, Harada H, Shigemoto R. 2021.High-Resolution localization
    and quantitation of membrane proteins by SDS-digested freeze-fracture replica
    labeling (SDS-FRL). In:  Receptor and Ion Channel Detection in the Brain. Neuromethods,
    vol. 169, 267–283.'
  mla: Kaufmann, Walter, et al. “High-Resolution Localization and Quantitation of
    Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL).”
    <i> Receptor and Ion Channel Detection in the Brain</i>, vol. 169, Humana, 2021,
    pp. 267–83, doi:<a href="https://doi.org/10.1007/978-1-0716-1522-5_19">10.1007/978-1-0716-1522-5_19</a>.
  short: W. Kaufmann, D. Kleindienst, H. Harada, R. Shigemoto, in:,  Receptor and
    Ion Channel Detection in the Brain, Humana, New York, 2021, pp. 267–283.
date_created: 2021-07-30T09:34:56Z
date_published: 2021-07-27T00:00:00Z
date_updated: 2024-03-25T23:30:16Z
day: '27'
ddc:
- '573'
department:
- _id: RySh
- _id: EM-Fac
doi: 10.1007/978-1-0716-1522-5_19
ec_funded: 1
has_accepted_license: '1'
intvolume: '       169'
keyword:
- 'Freeze-fracture replica: Deep learning'
- Immunogold labeling
- Integral membrane protein
- Electron microscopy
language:
- iso: eng
month: '07'
oa_version: None
page: 267-283
place: New York
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694539'
  name: 'In situ analysis of single channel subunit composition in neurons: physiological
    implication in synaptic plasticity and behaviour'
- _id: 25CBA828-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '720270'
  name: Human Brain Project Specific Grant Agreement 1 (HBP SGA 1)
publication: ' Receptor and Ion Channel Detection in the Brain'
publication_identifier:
  eisbn:
  - '9781071615225'
  isbn:
  - '9781071615218'
publication_status: published
publisher: Humana
quality_controlled: '1'
related_material:
  record:
  - id: '9562'
    relation: dissertation_contains
    status: public
series_title: Neuromethods
status: public
title: High-Resolution localization and quantitation of membrane proteins by SDS-digested
  freeze-fracture replica labeling (SDS-FRL)
type: book_chapter
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 169
year: '2021'
...
---
_id: '9759'
acknowledgement: The authors thank Inez Lam of Johns Hopkins University for valuable
  comments on an earlier version of the manuscript. We also thank the facilitators
  of the 2019–2020 eLife Community Ambassador program.
article_number: e1009124
article_processing_charge: Yes
article_type: letter_note
author:
- first_name: Michael John
  full_name: Bartlett, Michael John
  last_name: Bartlett
- first_name: Feyza N
  full_name: Arslan, Feyza N
  id: 49DA7910-F248-11E8-B48F-1D18A9856A87
  last_name: Arslan
  orcid: 0000-0001-5809-9566
- first_name: Adriana
  full_name: Bankston, Adriana
  last_name: Bankston
- first_name: Sarvenaz
  full_name: Sarabipour, Sarvenaz
  last_name: Sarabipour
citation:
  ama: Bartlett MJ, Arslan FN, Bankston A, Sarabipour S. Ten simple rules to improve
    academic work- life balance. <i>PLoS Computational Biology</i>. 2021;17(7). doi:<a
    href="https://doi.org/10.1371/journal.pcbi.1009124">10.1371/journal.pcbi.1009124</a>
  apa: Bartlett, M. J., Arslan, F. N., Bankston, A., &#38; Sarabipour, S. (2021).
    Ten simple rules to improve academic work- life balance. <i>PLoS Computational
    Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1009124">https://doi.org/10.1371/journal.pcbi.1009124</a>
  chicago: Bartlett, Michael John, Feyza N Arslan, Adriana Bankston, and Sarvenaz
    Sarabipour. “Ten Simple Rules to Improve Academic Work- Life Balance.” <i>PLoS
    Computational Biology</i>. Public Library of Science, 2021. <a href="https://doi.org/10.1371/journal.pcbi.1009124">https://doi.org/10.1371/journal.pcbi.1009124</a>.
  ieee: M. J. Bartlett, F. N. Arslan, A. Bankston, and S. Sarabipour, “Ten simple
    rules to improve academic work- life balance,” <i>PLoS Computational Biology</i>,
    vol. 17, no. 7. Public Library of Science, 2021.
  ista: Bartlett MJ, Arslan FN, Bankston A, Sarabipour S. 2021. Ten simple rules to
    improve academic work- life balance. PLoS Computational Biology. 17(7), e1009124.
  mla: Bartlett, Michael John, et al. “Ten Simple Rules to Improve Academic Work-
    Life Balance.” <i>PLoS Computational Biology</i>, vol. 17, no. 7, e1009124, Public
    Library of Science, 2021, doi:<a href="https://doi.org/10.1371/journal.pcbi.1009124">10.1371/journal.pcbi.1009124</a>.
  short: M.J. Bartlett, F.N. Arslan, A. Bankston, S. Sarabipour, PLoS Computational
    Biology 17 (2021).
date_created: 2021-08-01T22:01:21Z
date_published: 2021-07-15T00:00:00Z
date_updated: 2023-08-10T14:16:46Z
day: '15'
ddc:
- '613'
department:
- _id: CaHe
doi: 10.1371/journal.pcbi.1009124
external_id:
  isi:
  - '000677713500008'
  pmid:
  - '34264932'
file:
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  checksum: e56d91f0eeadb36f143a90e2c1b3ab63
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  date_created: 2021-08-05T12:06:49Z
  date_updated: 2021-08-05T12:06:49Z
  file_id: '9771'
  file_name: 2021_PlosCompBio_Bartlett.pdf
  file_size: 693633
  relation: main_file
file_date_updated: 2021-08-05T12:06:49Z
has_accepted_license: '1'
intvolume: '        17'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Computational Biology
publication_identifier:
  eissn:
  - '15537358'
  issn:
  - 1553734X
publication_status: published
publisher: Public Library of Science
scopus_import: '1'
status: public
title: Ten simple rules to improve academic work- life balance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '9760'
abstract:
- lang: eng
  text: "The quantum approximate optimization algorithm (QAOA) is a prospective near-term
    quantum algorithm due to its modest circuit depth and promising benchmarks. However,
    an external parameter optimization required in the QAOA could become a performance
    bottleneck. This motivates studies of the optimization landscape and search for
    heuristic ways of parameter initialization. In this work we visualize the optimization
    landscape of the QAOA applied to the MaxCut problem on random graphs, demonstrating
    that random initialization of the QAOA is prone to converging to local minima
    with suboptimal performance. We introduce the initialization of QAOA parameters
    based on the Trotterized quantum annealing (TQA) protocol, parameterized by the
    Trotter time step. We find that the TQA initialization allows to circumvent\r\nthe
    issue of false minima for a broad range of time steps, yielding the same performance
    as the best result out of an exponentially scaling number of random initializations.
    Moreover, we demonstrate that the optimal value of the time step coincides with
    the point of proliferation of Trotter errors in quantum annealing. Our results
    suggest practical ways of initializing QAOA protocols on near-term quantum devices
    and reveal new connections between QAOA and quantum annealing."
acknowledgement: We would like to thank D. Abanin and R. Medina for fruitful discussions
  and A. Smith and I. Kim for valuable feedback on the manuscript. We acknowledge
  support by the European Research Council (ERC) under the European Union’s Horizon
  2020 research and innovation program (Grant Agreement No. 850899).
article_number: '491'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Stefan
  full_name: Sack, Stefan
  id: dd622248-f6e0-11ea-865d-ce382a1c81a5
  last_name: Sack
  orcid: 0000-0001-5400-8508
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Sack S, Serbyn M. Quantum annealing initialization of the quantum approximate
    optimization algorithm. <i>Quantum</i>. 2021;5. doi:<a href="https://doi.org/10.22331/Q-2021-07-01-491">10.22331/Q-2021-07-01-491</a>
  apa: Sack, S., &#38; Serbyn, M. (2021). Quantum annealing initialization of the
    quantum approximate optimization algorithm. <i>Quantum</i>. Verein zur Förderung
    des Open Access Publizierens in den Quantenwissenschaften. <a href="https://doi.org/10.22331/Q-2021-07-01-491">https://doi.org/10.22331/Q-2021-07-01-491</a>
  chicago: Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the
    Quantum Approximate Optimization Algorithm.” <i>Quantum</i>. Verein zur Förderung
    des Open Access Publizierens in den Quantenwissenschaften, 2021. <a href="https://doi.org/10.22331/Q-2021-07-01-491">https://doi.org/10.22331/Q-2021-07-01-491</a>.
  ieee: S. Sack and M. Serbyn, “Quantum annealing initialization of the quantum approximate
    optimization algorithm,” <i>Quantum</i>, vol. 5. Verein zur Förderung des Open
    Access Publizierens in den Quantenwissenschaften, 2021.
  ista: Sack S, Serbyn M. 2021. Quantum annealing initialization of the quantum approximate
    optimization algorithm. Quantum. 5, 491.
  mla: Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum
    Approximate Optimization Algorithm.” <i>Quantum</i>, vol. 5, 491, Verein zur Förderung
    des Open Access Publizierens in den Quantenwissenschaften, 2021, doi:<a href="https://doi.org/10.22331/Q-2021-07-01-491">10.22331/Q-2021-07-01-491</a>.
  short: S. Sack, M. Serbyn, Quantum 5 (2021).
date_created: 2021-08-01T22:01:21Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-12-13T14:47:25Z
day: '01'
ddc:
- '530'
department:
- _id: GradSch
- _id: MaSe
doi: 10.22331/Q-2021-07-01-491
ec_funded: 1
external_id:
  arxiv:
  - '2101.05742'
  isi:
  - '000669830600001'
file:
- access_level: open_access
  checksum: 9706c2bb8e748e9b5b138381995a7f6f
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-08-06T06:44:31Z
  date_updated: 2021-08-06T06:44:31Z
  file_id: '9774'
  file_name: 2021_Quantum_Sack.pdf
  file_size: 2312482
  relation: main_file
file_date_updated: 2021-08-06T06:44:31Z
has_accepted_license: '1'
intvolume: '         5'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Quantum
publication_identifier:
  eissn:
  - 2521-327X
publication_status: published
publisher: Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften
quality_controlled: '1'
related_material:
  record:
  - id: '14622'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Quantum annealing initialization of the quantum approximate optimization algorithm
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2021'
...
---
_id: '9761'
abstract:
- lang: eng
  text: 'The important roles of mitochondrial function and dysfunction in the process
    of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear
    to be a highly vulnerable neuronal cell type in the central nervous system with
    respect to mitochondrial dysfunction but the actual reasons for this are still
    incompletely understood. These cells have a unique circumstance where unmyelinated
    axons must bend nearly 90° to exit the eye and then cross a translaminar pressure
    gradient before becoming myelinated in the optic nerve. This region, the optic
    nerve head, contains some of the highest density of mitochondria present in these
    cells. Glaucoma represents a perfect storm of events occurring at this location,
    with a combination of changes in the translaminar pressure gradient and reassignment
    of the metabolic support functions of supporting glia, which appears to apply
    increased metabolic stress to the RGC axons leading to a failure of axonal transport
    mechanisms. However, RGCs themselves are also extremely sensitive to genetic mutations,
    particularly in genes affecting mitochondrial dynamics and mitochondrial clearance.
    These mutations, which systemically affect the mitochondria in every cell, often
    lead to an optic neuropathy as the sole pathologic defect in affected patients.
    This review summarizes knowledge of mitochondrial structure and function, the
    known energy demands of neurons in general, and places these in the context of
    normal and pathological characteristics of mitochondria attributed to RGCs. '
acknowledgement: The authors are grateful to Kazuya Oikawa and Gillian McLellan for
  generously sharing some of their data for this review, and to Janis Eells for helpful
  comments on the manuscript.
article_number: '1593'
article_processing_charge: Yes
article_type: original
author:
- first_name: Nicole A.
  full_name: Muench, Nicole A.
  last_name: Muench
- first_name: Sonia
  full_name: Patel, Sonia
  last_name: Patel
- first_name: Margaret E
  full_name: Maes, Margaret E
  id: 3838F452-F248-11E8-B48F-1D18A9856A87
  last_name: Maes
  orcid: 0000-0001-9642-1085
- first_name: Ryan J.
  full_name: Donahue, Ryan J.
  last_name: Donahue
- first_name: Akihiro
  full_name: Ikeda, Akihiro
  last_name: Ikeda
- first_name: Robert W.
  full_name: Nickells, Robert W.
  last_name: Nickells
citation:
  ama: Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The influence
    of mitochondrial dynamics and function on retinal ganglion cell susceptibility
    in optic nerve disease. <i>Cells</i>. 2021;10(7). doi:<a href="https://doi.org/10.3390/cells10071593">10.3390/cells10071593</a>
  apa: Muench, N. A., Patel, S., Maes, M. E., Donahue, R. J., Ikeda, A., &#38; Nickells,
    R. W. (2021). The influence of mitochondrial dynamics and function on retinal
    ganglion cell susceptibility in optic nerve disease. <i>Cells</i>. MDPI. <a href="https://doi.org/10.3390/cells10071593">https://doi.org/10.3390/cells10071593</a>
  chicago: Muench, Nicole A., Sonia Patel, Margaret E Maes, Ryan J. Donahue, Akihiro
    Ikeda, and Robert W. Nickells. “The Influence of Mitochondrial Dynamics and Function
    on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.” <i>Cells</i>.
    MDPI, 2021. <a href="https://doi.org/10.3390/cells10071593">https://doi.org/10.3390/cells10071593</a>.
  ieee: N. A. Muench, S. Patel, M. E. Maes, R. J. Donahue, A. Ikeda, and R. W. Nickells,
    “The influence of mitochondrial dynamics and function on retinal ganglion cell
    susceptibility in optic nerve disease,” <i>Cells</i>, vol. 10, no. 7. MDPI, 2021.
  ista: Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. 2021. The influence
    of mitochondrial dynamics and function on retinal ganglion cell susceptibility
    in optic nerve disease. Cells. 10(7), 1593.
  mla: Muench, Nicole A., et al. “The Influence of Mitochondrial Dynamics and Function
    on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.” <i>Cells</i>,
    vol. 10, no. 7, 1593, MDPI, 2021, doi:<a href="https://doi.org/10.3390/cells10071593">10.3390/cells10071593</a>.
  short: N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells,
    Cells 10 (2021).
date_created: 2021-08-01T22:01:22Z
date_published: 2021-06-25T00:00:00Z
date_updated: 2023-08-10T14:14:53Z
day: '25'
ddc:
- '570'
department:
- _id: SaSi
doi: 10.3390/cells10071593
external_id:
  isi:
  - '000678193300001'
  pmid:
  - '34201955'
file:
- access_level: open_access
  checksum: e0497ce5c77fa3b65a538c7d6e0f6c66
  content_type: application/pdf
  creator: cziletti
  date_created: 2021-08-04T14:01:30Z
  date_updated: 2021-08-04T14:01:30Z
  file_id: '9768'
  file_name: 2021_Cells_Muench.pdf
  file_size: 4555611
  relation: main_file
  success: 1
file_date_updated: 2021-08-04T14:01:30Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
issue: '7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cells
publication_identifier:
  eissn:
  - '20734409'
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: The influence of mitochondrial dynamics and function on retinal ganglion cell
  susceptibility in optic nerve disease
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '9769'
abstract:
- lang: eng
  text: A few years ago, flow equations were introduced as a technique for calculating
    the ground-state energies of cold Bose gases with and without impurities. In this
    paper, we extend this approach to compute observables other than the energy. As
    an example, we calculate the densities, and phase fluctuations of one-dimensional
    Bose gases with one and two impurities. For a single mobile impurity, we use flow
    equations to validate the mean-field results obtained upon the Lee-Low-Pines transformation.
    We show that the mean-field approximation is accurate for all values of the boson-impurity
    interaction strength as long as the phase coherence length is much larger than
    the healing length of the condensate. For two static impurities, we calculate
    impurity-impurity interactions induced by the Bose gas. We find that leading order
    perturbation theory fails when boson-impurity interactions are stronger than boson-boson
    interactions. The mean-field approximation reproduces the flow equation results
    for all values of the boson-impurity interaction strength as long as boson-boson
    interactions are weak.
acknowledgement: We thank Matthias Heinz and Volker Karle for helpful comments on
  the manuscript; Zoran Ristivojevic for useful correspondence regarding mean-field
  calculations of induced impurity-impurity interactions; Fabian Grusdt for sharing
  with us the data for the densities presented in Ref. [14]. This work has received
  funding from the DFG Project No. 413495248 [VO 2437/1-1] (F. B., H.-W. H., A. G.
  V.) and European Union’s Horizon 2020 research and innovation programme under the
  Marie Skłodowska-Curie Grant Agreement No. 754411 (A. G. V.). M. L. acknowledges
  support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON).
  H.-W.H. thanks the ECT* for hospitality during the workshop “Universal physics in
  Many-Body Quantum Systems – From Atoms to Quarks". This infrastructure is part of
  a project that has received funding from the European Union’s Horizon 2020 research
  and innovation programme under grant agreement No 824093. H.-W.H. was supported
  by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Project-ID
  279384907 - SFB 1245.
article_number: '008'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Fabian
  full_name: Brauneis, Fabian
  last_name: Brauneis
- first_name: Hans-Werner
  full_name: Hammer, Hans-Werner
  last_name: Hammer
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Artem
  full_name: Volosniev, Artem
  id: 37D278BC-F248-11E8-B48F-1D18A9856A87
  last_name: Volosniev
  orcid: 0000-0003-0393-5525
citation:
  ama: 'Brauneis F, Hammer H-W, Lemeshko M, Volosniev A. Impurities in a one-dimensional
    Bose gas: The flow equation approach. <i>SciPost Physics</i>. 2021;11(1). doi:<a
    href="https://doi.org/10.21468/scipostphys.11.1.008">10.21468/scipostphys.11.1.008</a>'
  apa: 'Brauneis, F., Hammer, H.-W., Lemeshko, M., &#38; Volosniev, A. (2021). Impurities
    in a one-dimensional Bose gas: The flow equation approach. <i>SciPost Physics</i>.
    SciPost. <a href="https://doi.org/10.21468/scipostphys.11.1.008">https://doi.org/10.21468/scipostphys.11.1.008</a>'
  chicago: 'Brauneis, Fabian, Hans-Werner Hammer, Mikhail Lemeshko, and Artem Volosniev.
    “Impurities in a One-Dimensional Bose Gas: The Flow Equation Approach.” <i>SciPost
    Physics</i>. SciPost, 2021. <a href="https://doi.org/10.21468/scipostphys.11.1.008">https://doi.org/10.21468/scipostphys.11.1.008</a>.'
  ieee: 'F. Brauneis, H.-W. Hammer, M. Lemeshko, and A. Volosniev, “Impurities in
    a one-dimensional Bose gas: The flow equation approach,” <i>SciPost Physics</i>,
    vol. 11, no. 1. SciPost, 2021.'
  ista: 'Brauneis F, Hammer H-W, Lemeshko M, Volosniev A. 2021. Impurities in a one-dimensional
    Bose gas: The flow equation approach. SciPost Physics. 11(1), 008.'
  mla: 'Brauneis, Fabian, et al. “Impurities in a One-Dimensional Bose Gas: The Flow
    Equation Approach.” <i>SciPost Physics</i>, vol. 11, no. 1, 008, SciPost, 2021,
    doi:<a href="https://doi.org/10.21468/scipostphys.11.1.008">10.21468/scipostphys.11.1.008</a>.'
  short: F. Brauneis, H.-W. Hammer, M. Lemeshko, A. Volosniev, SciPost Physics 11
    (2021).
date_created: 2021-08-04T15:00:55Z
date_published: 2021-07-13T00:00:00Z
date_updated: 2023-08-11T10:25:44Z
day: '13'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.21468/scipostphys.11.1.008
ec_funded: 1
external_id:
  arxiv:
  - '2101.10958'
  isi:
  - '000680039500013'
file:
- access_level: open_access
  checksum: eaa847346b1a023d97bbb291779610ed
  content_type: application/pdf
  creator: asandaue
  date_created: 2021-08-10T11:44:59Z
  date_updated: 2021-08-10T11:44:59Z
  file_id: '9875'
  file_name: 2021_SciPostPhysics_Brauneis.pdf
  file_size: 1085300
  relation: main_file
  success: 1
file_date_updated: 2021-08-10T11:44:59Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
issue: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
publication: SciPost Physics
publication_identifier:
  eissn:
  - 2542-4653
publication_status: published
publisher: SciPost
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Impurities in a one-dimensional Bose gas: The flow equation approach'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...
