[{"file":[{"success":1,"relation":"main_file","content_type":"application/pdf","checksum":"6269ed3b3eded6536d3d9d6baad2d5b9","file_size":448736,"date_created":"2023-05-22T07:43:19Z","file_name":"2023_JourCombinatorics_Anastos.pdf","creator":"dernst","date_updated":"2023-05-22T07:43:19Z","access_level":"open_access","file_id":"13046"}],"month":"05","publication":"Electronic Journal of Combinatorics","file_date_updated":"2023-05-22T07:43:19Z","publisher":"Electronic Journal of Combinatorics","has_accepted_license":"1","_id":"13042","arxiv":1,"publication_status":"published","date_updated":"2023-08-01T14:44:52Z","status":"public","license":"https://creativecommons.org/licenses/by/4.0/","ddc":["510"],"date_published":"2023-05-05T00:00:00Z","year":"2023","publication_identifier":{"eissn":["1077-8926"]},"article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"isi":1,"external_id":{"arxiv":["2105.13828"],"isi":["000988285500001"]},"author":[{"id":"0b2a4358-bb35-11ec-b7b9-e3279b593dbb","last_name":"Anastos","full_name":"Anastos, Michael","first_name":"Michael"}],"acknowledgement":"We would like to thank the reviewers for their helpful comments and remarks.","oa_version":"Published Version","doi":"10.37236/11471","quality_controlled":"1","day":"05","type":"journal_article","citation":{"mla":"Anastos, Michael. “A Note on Long Cycles in Sparse Random Graphs.” <i>Electronic Journal of Combinatorics</i>, vol. 30, no. 2, P2.21, Electronic Journal of Combinatorics, 2023, doi:<a href=\"https://doi.org/10.37236/11471\">10.37236/11471</a>.","ieee":"M. Anastos, “A note on long cycles in sparse random graphs,” <i>Electronic Journal of Combinatorics</i>, vol. 30, no. 2. Electronic Journal of Combinatorics, 2023.","ama":"Anastos M. A note on long cycles in sparse random graphs. <i>Electronic Journal of Combinatorics</i>. 2023;30(2). doi:<a href=\"https://doi.org/10.37236/11471\">10.37236/11471</a>","short":"M. Anastos, Electronic Journal of Combinatorics 30 (2023).","apa":"Anastos, M. (2023). A note on long cycles in sparse random graphs. <i>Electronic Journal of Combinatorics</i>. Electronic Journal of Combinatorics. <a href=\"https://doi.org/10.37236/11471\">https://doi.org/10.37236/11471</a>","chicago":"Anastos, Michael. “A Note on Long Cycles in Sparse Random Graphs.” <i>Electronic Journal of Combinatorics</i>. Electronic Journal of Combinatorics, 2023. <a href=\"https://doi.org/10.37236/11471\">https://doi.org/10.37236/11471</a>.","ista":"Anastos M. 2023. A note on long cycles in sparse random graphs. Electronic Journal of Combinatorics. 30(2), P2.21."},"language":[{"iso":"eng"}],"date_created":"2023-05-21T22:01:05Z","department":[{"_id":"MaKw"}],"title":"A note on long cycles in sparse random graphs","scopus_import":"1","abstract":[{"lang":"eng","text":"Let Lc,n denote the size of the longest cycle in G(n, c/n),c >1 constant.  We show that there exists a continuous function f(c) such that Lc,n/n→f(c) a.s.  for c>20,  thus  extending  a  result  of  Frieze  and  the  author  to  smaller  values  of c. Thereafter,  for c>20,  we  determine  the  limit  of  the  probability  that G(n, c/n)contains  cycles  of  every  length  between  the  length  of  its  shortest  and  its  longest cycles as n→∞."}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":30,"intvolume":"        30","issue":"2","article_type":"original","article_number":"P2.21"},{"file_date_updated":"2023-05-22T07:24:13Z","has_accepted_license":"1","publisher":"EMS Press","file":[{"file_id":"13045","access_level":"open_access","creator":"dernst","date_updated":"2023-05-22T07:24:13Z","file_name":"2023_Interfaces_Hensel.pdf","date_created":"2023-05-22T07:24:13Z","file_size":867876,"checksum":"622422484810441e48f613e968c7e7a4","relation":"main_file","content_type":"application/pdf","success":1}],"month":"04","publication":"Interfaces and Free Boundaries","ddc":["510"],"date_published":"2023-04-20T00:00:00Z","status":"public","year":"2023","publication_identifier":{"issn":["1463-9963"],"eissn":["1463-9971"]},"article_processing_charge":"No","page":"37-107","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"external_id":{"isi":["000975817300002"],"arxiv":["2108.01733"]},"author":[{"first_name":"Sebastian","full_name":"Hensel, Sebastian","orcid":"0000-0001-7252-8072","last_name":"Hensel","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Laux","full_name":"Laux, Tim","first_name":"Tim"}],"isi":1,"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 948819), and from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1 – 390685813.","arxiv":1,"_id":"13043","publication_status":"published","ec_funded":1,"date_updated":"2023-08-01T14:43:29Z","project":[{"_id":"0aa76401-070f-11eb-9043-b5bb049fa26d","grant_number":"948819","call_identifier":"H2020","name":"Bridging Scales in Random Materials"}],"type":"journal_article","day":"20","related_material":{"record":[{"relation":"earlier_version","status":"public","id":"10013"}]},"citation":{"mla":"Hensel, Sebastian, and Tim Laux. “Weak-Strong Uniqueness for the Mean Curvature Flow of Double Bubbles.” <i>Interfaces and Free Boundaries</i>, vol. 25, no. 1, EMS Press, 2023, pp. 37–107, doi:<a href=\"https://doi.org/10.4171/IFB/484\">10.4171/IFB/484</a>.","ama":"Hensel S, Laux T. Weak-strong uniqueness for the mean curvature flow of double bubbles. <i>Interfaces and Free Boundaries</i>. 2023;25(1):37-107. doi:<a href=\"https://doi.org/10.4171/IFB/484\">10.4171/IFB/484</a>","ieee":"S. Hensel and T. Laux, “Weak-strong uniqueness for the mean curvature flow of double bubbles,” <i>Interfaces and Free Boundaries</i>, vol. 25, no. 1. EMS Press, pp. 37–107, 2023.","short":"S. Hensel, T. Laux, Interfaces and Free Boundaries 25 (2023) 37–107.","apa":"Hensel, S., &#38; Laux, T. (2023). Weak-strong uniqueness for the mean curvature flow of double bubbles. <i>Interfaces and Free Boundaries</i>. EMS Press. <a href=\"https://doi.org/10.4171/IFB/484\">https://doi.org/10.4171/IFB/484</a>","ista":"Hensel S, Laux T. 2023. Weak-strong uniqueness for the mean curvature flow of double bubbles. Interfaces and Free Boundaries. 25(1), 37–107.","chicago":"Hensel, Sebastian, and Tim Laux. “Weak-Strong Uniqueness for the Mean Curvature Flow of Double Bubbles.” <i>Interfaces and Free Boundaries</i>. EMS Press, 2023. <a href=\"https://doi.org/10.4171/IFB/484\">https://doi.org/10.4171/IFB/484</a>."},"oa_version":"Published Version","quality_controlled":"1","doi":"10.4171/IFB/484","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":25,"abstract":[{"text":"We derive a weak-strong uniqueness principle for BV solutions to multiphase mean curvature flow of triple line clusters in three dimensions. Our proof is based on the explicit construction\r\nof a gradient flow calibration in the sense of the recent work of Fischer et al. (2020) for any such\r\ncluster. This extends the two-dimensional construction to the three-dimensional case of surfaces\r\nmeeting along triple junctions.","lang":"eng"}],"intvolume":"        25","issue":"1","article_type":"original","language":[{"iso":"eng"}],"date_created":"2023-05-21T22:01:06Z","department":[{"_id":"JuFi"}],"title":"Weak-strong uniqueness for the mean curvature flow of double bubbles","scopus_import":"1"},{"oa_version":"Published Version","doi":"10.1039/d3fd00088e","quality_controlled":"1","citation":{"ista":"Mondal S, Jethwa RB, Pant B, Hauschild R, Freunberger SA. 2023. Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes. Faraday Discussions.","chicago":"Mondal, Soumyadip, Rajesh B Jethwa, Bhargavi Pant, Robert Hauschild, and Stefan Alexander Freunberger. “Singlet Oxygen in Non-Aqueous Oxygen Redox: Direct Spectroscopic Evidence for Formation Pathways and Reliability of Chemical Probes.” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2023. <a href=\"https://doi.org/10.1039/d3fd00088e\">https://doi.org/10.1039/d3fd00088e</a>.","apa":"Mondal, S., Jethwa, R. B., Pant, B., Hauschild, R., &#38; Freunberger, S. A. (2023). Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes. <i>Faraday Discussions</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3fd00088e\">https://doi.org/10.1039/d3fd00088e</a>","short":"S. Mondal, R.B. Jethwa, B. Pant, R. Hauschild, S.A. Freunberger, Faraday Discussions (2023).","ieee":"S. Mondal, R. B. Jethwa, B. Pant, R. Hauschild, and S. A. Freunberger, “Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes,” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2023.","ama":"Mondal S, Jethwa RB, Pant B, Hauschild R, Freunberger SA. Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes. <i>Faraday Discussions</i>. 2023. doi:<a href=\"https://doi.org/10.1039/d3fd00088e\">10.1039/d3fd00088e</a>","mla":"Mondal, Soumyadip, et al. “Singlet Oxygen in Non-Aqueous Oxygen Redox: Direct Spectroscopic Evidence for Formation Pathways and Reliability of Chemical Probes.” <i>Faraday Discussions</i>, Royal Society of Chemistry, 2023, doi:<a href=\"https://doi.org/10.1039/d3fd00088e\">10.1039/d3fd00088e</a>."},"type":"journal_article","day":"17","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/d3fd00088e"}],"department":[{"_id":"StFr"},{"_id":"Bio"}],"language":[{"iso":"eng"}],"date_created":"2023-05-22T06:53:34Z","title":"Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes","tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"abstract":[{"lang":"eng","text":"Singlet oxygen (1O2) formation is now recognised as a key aspect of non-aqueous oxygen redox chemistry. For identifying 1O2, chemical trapping via 9,10-dimethylanthracene (DMA) to form the endoperoxide (DMA-O2) has become the mainstay method due to its sensitivity, selectivity, and ease of use. While DMA has been shown to be selective for 1O2, rather than forming DMA-O2 with a wide variety of potentially reactive O-containing species, false positives might hypothetically be obtained in the presence of previously overlooked species. Here, we first give unequivocal direct spectroscopic proof by the 1O2-specific near infrared (NIR) emission at 1270 nm for the previously proposed 1O2 formation pathways, which centre around superoxide disproportionation. We then show that peroxocarbonates, common intermediates in metal-O2 and metal carbonate electrochemistry, do not produce false-positive DMA-O2. Moreover, we identify a previously unreported 1O2-forming pathway through the reaction of CO2 with superoxide. Overall, we give unequivocal proof for 1O2 formation in non-aqueous oxygen redox and show that chemical trapping with DMA is a reliable method to assess 1O2 formation."}],"article_type":"original","month":"05","publication":"Faraday Discussions","publisher":"Royal Society of Chemistry","_id":"13044","date_updated":"2023-12-13T11:19:07Z","publication_status":"epub_ahead","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","license":"https://creativecommons.org/licenses/by-nc/4.0/","date_published":"2023-05-17T00:00:00Z","year":"2023","publication_identifier":{"issn":["1359-6640"],"eissn":["1364-5498"]},"keyword":["Physical and Theoretical Chemistry"],"oa":1,"external_id":{"isi":["001070423500001"]},"author":[{"last_name":"Mondal","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","full_name":"Mondal, Soumyadip","first_name":"Soumyadip"},{"orcid":"0000-0002-0404-4356","full_name":"Jethwa, Rajesh B","first_name":"Rajesh B","last_name":"Jethwa","id":"4cc538d5-803f-11ed-ab7e-8139573aad8f"},{"first_name":"Bhargavi","full_name":"Pant, Bhargavi","id":"50c64d4d-eb97-11eb-a6c2-d33e5e14f112","last_name":"Pant"},{"orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert","first_name":"Robert","last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319"}],"isi":1},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2303.04014"}],"citation":{"mla":"Lieutier, André, and Mathijs Wintraecken. “Hausdorff and Gromov-Hausdorff Stable Subsets of the Medial Axis.” <i>Proceedings of the 55th Annual ACM Symposium on Theory of Computing</i>, Association for Computing Machinery, 2023, pp. 1768–76, doi:<a href=\"https://doi.org/10.1145/3564246.3585113\">10.1145/3564246.3585113</a>.","ista":"Lieutier A, Wintraecken M. 2023. Hausdorff and Gromov-Hausdorff stable subsets of the medial axis. Proceedings of the 55th Annual ACM Symposium on Theory of Computing. STOC: Symposium on Theory of Computing, 1768–1776.","chicago":"Lieutier, André, and Mathijs Wintraecken. “Hausdorff and Gromov-Hausdorff Stable Subsets of the Medial Axis.” In <i>Proceedings of the 55th Annual ACM Symposium on Theory of Computing</i>, 1768–76. Association for Computing Machinery, 2023. <a href=\"https://doi.org/10.1145/3564246.3585113\">https://doi.org/10.1145/3564246.3585113</a>.","apa":"Lieutier, A., &#38; Wintraecken, M. (2023). Hausdorff and Gromov-Hausdorff stable subsets of the medial axis. In <i>Proceedings of the 55th Annual ACM Symposium on Theory of Computing</i> (pp. 1768–1776). Orlando, FL, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3564246.3585113\">https://doi.org/10.1145/3564246.3585113</a>","ieee":"A. Lieutier and M. Wintraecken, “Hausdorff and Gromov-Hausdorff stable subsets of the medial axis,” in <i>Proceedings of the 55th Annual ACM Symposium on Theory of Computing</i>, Orlando, FL, United States, 2023, pp. 1768–1776.","ama":"Lieutier A, Wintraecken M. Hausdorff and Gromov-Hausdorff stable subsets of the medial axis. In: <i>Proceedings of the 55th Annual ACM Symposium on Theory of Computing</i>. Association for Computing Machinery; 2023:1768-1776. doi:<a href=\"https://doi.org/10.1145/3564246.3585113\">10.1145/3564246.3585113</a>","short":"A. Lieutier, M. Wintraecken, in:, Proceedings of the 55th Annual ACM Symposium on Theory of Computing, Association for Computing Machinery, 2023, pp. 1768–1776."},"type":"conference","day":"02","quality_controlled":"1","doi":"10.1145/3564246.3585113","oa_version":"Preprint","abstract":[{"lang":"eng","text":"In this paper we introduce a pruning of the medial axis called the (λ,α)-medial axis (axλα). We prove that the (λ,α)-medial axis of a set K is stable in a Gromov-Hausdorff sense under weak assumptions. More formally we prove that if K and K′ are close in the Hausdorff (dH) sense then the (λ,α)-medial axes of K and K′ are close as metric spaces, that is the Gromov-Hausdorff distance (dGH) between the two is 1/4-Hölder in the sense that dGH (axλα(K),axλα(K′)) ≲ dH(K,K′)1/4. The Hausdorff distance between the two medial axes is also bounded, by dH (axλα(K),λα(K′)) ≲ dH(K,K′)1/2. These quantified stability results provide guarantees for practical computations of medial axes from approximations. Moreover, they provide key ingredients for studying the computability of the medial axis in the context of computable analysis."}],"title":"Hausdorff and Gromov-Hausdorff stable subsets of the medial axis","department":[{"_id":"HeEd"}],"language":[{"iso":"eng"}],"conference":{"location":"Orlando, FL, United States","end_date":"2023-06-23","name":"STOC: Symposium on Theory of Computing","start_date":"2023-06-20"},"date_created":"2023-05-22T08:02:02Z","publisher":"Association for Computing Machinery","publication":"Proceedings of the 55th Annual ACM Symposium on Theory of Computing","month":"06","acknowledgement":"We are greatly indebted to Erin Chambers for posing a number of questions that eventually led to this paper. We would also like to thank the other organizers of the workshop on ‘Algorithms\r\nfor the medial axis’. We are also indebted to Tatiana Ezubova for helping with the search for and translation of Russian literature. The second author thanks all members of the Edelsbrunner and Datashape groups for the atmosphere in which the research was conducted.\r\nThe research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement No. 339025 GUDHI (Algorithmic Foundations of Geometry Understanding in Higher Dimensions). Supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411. The Austrian science fund (FWF) M-3073.","external_id":{"arxiv":["2303.04014"]},"author":[{"last_name":"Lieutier","first_name":"André","full_name":"Lieutier, André"},{"last_name":"Wintraecken","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7472-2220","first_name":"Mathijs","full_name":"Wintraecken, Mathijs"}],"oa":1,"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1768-1776","date_published":"2023-06-02T00:00:00Z","status":"public","publication_identifier":{"isbn":["9781450399135"]},"year":"2023","date_updated":"2023-05-22T08:15:19Z","project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"},{"_id":"fc390959-9c52-11eb-aca3-afa58bd282b2","grant_number":"M03073","name":"Learning and triangulating manifolds via collapses"}],"ec_funded":1,"publication_status":"published","arxiv":1,"_id":"13048"},{"author":[{"last_name":"Freire","first_name":"Marco","full_name":"Freire, Marco"},{"id":"FF8FA64C-AA6A-11E9-99AD-50D4E5697425","last_name":"Bhargava","first_name":"Manas","full_name":"Bhargava, Manas","orcid":"0009-0007-6138-6890"},{"first_name":"Camille","full_name":"Schreck, Camille","id":"2B14B676-F248-11E8-B48F-1D18A9856A87","last_name":"Schreck"},{"last_name":"Hugron","first_name":"Pierre-Alexandre","full_name":"Hugron, Pierre-Alexandre"},{"last_name":"Bickel","id":"49876194-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6511-9385","full_name":"Bickel, Bernd","first_name":"Bernd"},{"first_name":"Sylvain","full_name":"Lefebvre, Sylvain","last_name":"Lefebvre"}],"oa":1,"external_id":{"isi":["001044671300108"]},"keyword":["PCB design and layout","Mesh geometry models"],"isi":1,"acknowledgement":"We thank the reviewers for the valuable feedback. We also thank the Miba Machine Shop at ISTA, PCBWay, and PragoBoard for helping us with fabrication and assembly. This project was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 715767 – MATERIALIZABLE).","year":"2023","publication_identifier":{"issn":["0730-0301"],"eissn":["1557-7368"]},"status":"public","date_published":"2023-07-26T00:00:00Z","ddc":["006"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","publication_status":"published","ec_funded":1,"project":[{"_id":"24F9549A-B435-11E9-9278-68D0E5697425","grant_number":"715767","call_identifier":"H2020","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"date_updated":"2024-01-29T10:30:49Z","_id":"13049","has_accepted_license":"1","publisher":"Association for Computing Machinery","file_date_updated":"2023-06-20T12:20:51Z","publication":"Transactions on Graphics","file":[{"date_updated":"2023-06-19T11:02:23Z","creator":"dernst","access_level":"open_access","file_id":"13156","date_created":"2023-06-19T11:02:23Z","file_name":"2023_ACMToG_Freire.pdf","checksum":"a0b0ba3b36f43a94388e8824613d812a","file_size":78940724,"success":1,"relation":"main_file","content_type":"application/pdf"},{"checksum":"b9206bbb67af82df49b7e7cdbde3410c","file_size":34345905,"success":1,"relation":"main_file","content_type":"application/pdf","creator":"dernst","date_updated":"2023-06-20T12:20:51Z","access_level":"open_access","file_id":"13157","file_name":"2023_ACMToG_SuppMaterial_Freire.pdf","date_created":"2023-06-20T12:20:51Z"}],"month":"07","article_type":"original","issue":"4","article_number":"142","intvolume":"        42","acknowledged_ssus":[{"_id":"M-Shop"}],"volume":42,"abstract":[{"lang":"eng","text":"We propose a computational design approach for covering a surface with individually addressable RGB LEDs, effectively forming a low-resolution surface screen. To achieve a low-cost and scalable approach, we propose creating designs from flat PCB panels bent in-place along the surface of a 3D printed core. Working with standard rigid PCBs enables the use of\r\nestablished PCB manufacturing services, allowing the fabrication of designs with several hundred LEDs. \r\nOur approach optimizes the PCB geometry for folding, and then jointly optimizes the LED packing, circuit and routing, solving a challenging layout problem under strict manufacturing requirements. Unlike paper, PCBs cannot bend beyond a certain point without breaking. Therefore, we introduce parametric cut patterns acting as hinges, designed to allow bending while remaining compact. To tackle the joint optimization of placement, circuit and routing, we propose a specialized algorithm that splits the global problem into one sub-problem per triangle, which is then individually solved.\r\nOur technique generates PCB blueprints in a completely automated way. After being fabricated by a PCB manufacturing service, the boards are bent and glued by the user onto the 3D printed support. We demonstrate our technique on a range of physical models and virtual examples, creating intricate surface light patterns from hundreds of LEDs."}],"title":"PCBend: Light up your 3D shapes with foldable circuit boards","date_created":"2023-05-22T08:37:04Z","conference":{"start_date":"2023-08-06","location":"Los Angeles, CA, United States","end_date":"2023-08-10","name":"SIGGRAPH: Computer Graphics and Interactive Techniques Conference"},"language":[{"iso":"eng"}],"department":[{"_id":"GradSch"},{"_id":"BeBi"}],"day":"26","type":"journal_article","citation":{"mla":"Freire, Marco, et al. “PCBend: Light up Your 3D Shapes with Foldable Circuit Boards.” <i>Transactions on Graphics</i>, vol. 42, no. 4, 142, Association for Computing Machinery, 2023, doi:<a href=\"https://doi.org/10.1145/3592411\">10.1145/3592411</a>.","short":"M. Freire, M. Bhargava, C. Schreck, P.-A. Hugron, B. Bickel, S. Lefebvre, Transactions on Graphics 42 (2023).","ama":"Freire M, Bhargava M, Schreck C, Hugron P-A, Bickel B, Lefebvre S. PCBend: Light up your 3D shapes with foldable circuit boards. <i>Transactions on Graphics</i>. 2023;42(4). doi:<a href=\"https://doi.org/10.1145/3592411\">10.1145/3592411</a>","ieee":"M. Freire, M. Bhargava, C. Schreck, P.-A. Hugron, B. Bickel, and S. Lefebvre, “PCBend: Light up your 3D shapes with foldable circuit boards,” <i>Transactions on Graphics</i>, vol. 42, no. 4. Association for Computing Machinery, 2023.","ista":"Freire M, Bhargava M, Schreck C, Hugron P-A, Bickel B, Lefebvre S. 2023. PCBend: Light up your 3D shapes with foldable circuit boards. Transactions on Graphics. 42(4), 142.","chicago":"Freire, Marco, Manas Bhargava, Camille Schreck, Pierre-Alexandre Hugron, Bernd Bickel, and Sylvain Lefebvre. “PCBend: Light up Your 3D Shapes with Foldable Circuit Boards.” <i>Transactions on Graphics</i>. Association for Computing Machinery, 2023. <a href=\"https://doi.org/10.1145/3592411\">https://doi.org/10.1145/3592411</a>.","apa":"Freire, M., Bhargava, M., Schreck, C., Hugron, P.-A., Bickel, B., &#38; Lefebvre, S. (2023). PCBend: Light up your 3D shapes with foldable circuit boards. <i>Transactions on Graphics</i>. Los Angeles, CA, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3592411\">https://doi.org/10.1145/3592411</a>"},"doi":"10.1145/3592411","quality_controlled":"1","oa_version":"Submitted Version"},{"type":"book_chapter","day":"28","citation":{"mla":"Leithner, Alexander F., et al. “En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses.” <i>The Immune Synapse</i>, edited by Cosima Baldari and Michael Dustin, vol. 2654, Springer Nature, 2023, pp. 137–47, doi:<a href=\"https://doi.org/10.1007/978-1-0716-3135-5_9\">10.1007/978-1-0716-3135-5_9</a>.","ieee":"A. F. Leithner, J. Merrin, and M. K. Sixt, “En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses,” in <i>The Immune Synapse</i>, vol. 2654, C. Baldari and M. Dustin, Eds. New York, NY: Springer Nature, 2023, pp. 137–147.","ama":"Leithner AF, Merrin J, Sixt MK. En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses. In: Baldari C, Dustin M, eds. <i>The Immune Synapse</i>. Vol 2654. MIMB. New York, NY: Springer Nature; 2023:137-147. doi:<a href=\"https://doi.org/10.1007/978-1-0716-3135-5_9\">10.1007/978-1-0716-3135-5_9</a>","short":"A.F. Leithner, J. Merrin, M.K. Sixt, in:, C. Baldari, M. Dustin (Eds.), The Immune Synapse, Springer Nature, New York, NY, 2023, pp. 137–147.","apa":"Leithner, A. F., Merrin, J., &#38; Sixt, M. K. (2023). En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses. In C. Baldari &#38; M. Dustin (Eds.), <i>The Immune Synapse</i> (Vol. 2654, pp. 137–147). New York, NY: Springer Nature. <a href=\"https://doi.org/10.1007/978-1-0716-3135-5_9\">https://doi.org/10.1007/978-1-0716-3135-5_9</a>","ista":"Leithner AF, Merrin J, Sixt MK. 2023.En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses. In: The Immune Synapse. Methods in Molecular Biology, vol. 2654, 137–147.","chicago":"Leithner, Alexander F, Jack Merrin, and Michael K Sixt. “En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses.” In <i>The Immune Synapse</i>, edited by Cosima Baldari and Michael Dustin, 2654:137–47. MIMB. New York, NY: Springer Nature, 2023. <a href=\"https://doi.org/10.1007/978-1-0716-3135-5_9\">https://doi.org/10.1007/978-1-0716-3135-5_9</a>."},"quality_controlled":"1","doi":"10.1007/978-1-0716-3135-5_9","place":"New York, NY","oa_version":"None","intvolume":"      2654","acknowledged_ssus":[{"_id":"Bio"},{"_id":"NanoFab"},{"_id":"M-Shop"}],"volume":2654,"abstract":[{"text":"Imaging of the immunological synapse (IS) between dendritic cells (DCs) and T cells in suspension is hampered by suboptimal alignment of cell-cell contacts along the vertical imaging plane. This requires optical sectioning that often results in unsatisfactory resolution in time and space. Here, we present a workflow where DCs and T cells are confined between a layer of glass and polydimethylsiloxane (PDMS) that orients the cells along one, horizontal imaging plane, allowing for fast en-face-imaging of the DC-T cell IS.","lang":"eng"}],"title":"En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses","scopus_import":"1","alternative_title":["Methods in Molecular Biology"],"language":[{"iso":"eng"}],"date_created":"2023-05-22T08:41:48Z","department":[{"_id":"MiSi"},{"_id":"NanoFab"}],"publisher":"Springer Nature","pmid":1,"series_title":"MIMB","publication":"The Immune Synapse","month":"04","author":[{"first_name":"Alexander F","full_name":"Leithner, Alexander F","orcid":"0000-0002-1073-744X","last_name":"Leithner","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Merrin","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack","first_name":"Jack","orcid":"0000-0001-5145-4609"},{"orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"pmid":["37106180"]},"editor":[{"last_name":"Baldari","first_name":"Cosima","full_name":"Baldari, Cosima"},{"full_name":"Dustin, Michael","first_name":"Michael","last_name":"Dustin"}],"acknowledgement":"A.L. was funded by an Erwin Schrödinger postdoctoral fellowship of the Austrian Science Fund (FWF, project number: J4542-B) and is an EMBO non-stipendiary postdoctoral fellow. This work was supported by a European Research Council grant ERC-CoG-72437 to M.S. We thank the Imaging & Optics facility, the Nanofabrication facility, and the Miba Machine Shop of ISTA for their excellent support.","date_published":"2023-04-28T00:00:00Z","status":"public","year":"2023","publication_identifier":{"isbn":["9781071631348"],"eissn":["1940-6029"],"eisbn":["9781071631355"],"issn":["1064-3745"]},"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"137-147","publication_status":"published","ec_funded":1,"date_updated":"2023-10-17T08:44:53Z","project":[{"grant_number":"724373","_id":"25FE9508-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Cellular navigation along spatial gradients"}],"_id":"13052"},{"oa_version":"Published Version","doi":"10.1016/j.ijms.2023.117168","quality_controlled":"1","type":"journal_article","day":"23","citation":{"ama":"Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. Advanced motion tracking for interactive mass spectrometry imaging (IMSI). <i>International Journal of Mass Spectrometry</i>. 2023;495. doi:<a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">10.1016/j.ijms.2023.117168</a>","short":"F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, T. Müller, International Journal of Mass Spectrometry 495 (2023).","ieee":"F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, and T. Müller, “Advanced motion tracking for interactive mass spectrometry imaging (IMSI),” <i>International Journal of Mass Spectrometry</i>, vol. 495. Elsevier, 2023.","ista":"Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. 2023. Advanced motion tracking for interactive mass spectrometry imaging (IMSI). International Journal of Mass Spectrometry. 495, 117168.","apa":"Kluibenschedl, F., Ploner, A., Meisenbichler, C., Konrat, R., &#38; Müller, T. (2023). Advanced motion tracking for interactive mass spectrometry imaging (IMSI). <i>International Journal of Mass Spectrometry</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">https://doi.org/10.1016/j.ijms.2023.117168</a>","chicago":"Kluibenschedl, Florian, Anna Ploner, Christina Meisenbichler, Robert Konrat, and Thomas Müller. “Advanced Motion Tracking for Interactive Mass Spectrometry Imaging (IMSI).” <i>International Journal of Mass Spectrometry</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">https://doi.org/10.1016/j.ijms.2023.117168</a>.","mla":"Kluibenschedl, Florian, et al. “Advanced Motion Tracking for Interactive Mass Spectrometry Imaging (IMSI).” <i>International Journal of Mass Spectrometry</i>, vol. 495, 117168, Elsevier, 2023, doi:<a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">10.1016/j.ijms.2023.117168</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.ijms.2023.117168"}],"language":[{"iso":"eng"}],"date_created":"2023-12-10T23:00:57Z","department":[{"_id":"GradSch"}],"title":"Advanced motion tracking for interactive mass spectrometry imaging (IMSI)","scopus_import":"1","abstract":[{"lang":"eng","text":"Mass spectrometry imaging (MSI) is a powerful analytical technique for the two-dimensional (2D) localization of chemicals on surfaces. Conventional MSI experiments require to predefine the surface of interest based on photographic or microscopic images. Typically, these boundaries can no longer be changed or adjusted once the experiment has been started. In terms of a more interactive approach we recently developed a pen-like ionization interface which is directly connected to the mass spectrometer. The device allows the user to ionize chemicals by desorption electrospray ionization (DESI) and to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging experiment: interactive mass spectrometry imaging (IMSI). For this application, we present a novel approach for a robust, optical flow-based motion detection. While the live video stream from the camera is used to track the pen's motion across the surface a post-acquisition algorithm correlates the coordinates of the pen trajectory with respective mass spectra obtained from a simultaneous mass spectrometric data acquisition. This algorithm is no longer dependent on a single, manually applied optical marker on the sample surface, which has to be visible on all video frames throughout the analysis. The advanced DESI-IMSI method was successfully tested on inkjet-printed letters as well as mouse brain tissue samples. Validation of the results was done by comparing DESI-IMSI with standard DESI-MSI data."}],"researchdata_availability":"upon request","volume":495,"intvolume":"       495","article_type":"original","article_number":"117168","month":"11","dataavailabilitystatement":"Data will be made available on request.","publication":"International Journal of Mass Spectrometry","supplementarymaterial":"yes","publisher":"Elsevier","_id":"14653","publication_status":"epub_ahead","date_updated":"2026-03-02T09:38:59Z","date_published":"2023-11-23T00:00:00Z","status":"public","publication_identifier":{"issn":["1387-3806"]},"year":"2023","article_processing_charge":"Yes (in subscription journal)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"author":[{"id":"7499e70e-eb2c-11ec-b98b-f925648bc9d9","last_name":"Kluibenschedl","first_name":"Florian","full_name":"Kluibenschedl, Florian"},{"full_name":"Ploner, Anna","first_name":"Anna","last_name":"Ploner"},{"first_name":"Christina","full_name":"Meisenbichler, Christina","last_name":"Meisenbichler"},{"full_name":"Konrat, Robert","first_name":"Robert","last_name":"Konrat"},{"last_name":"Müller","first_name":"Thomas","full_name":"Müller, Thomas"}],"acknowledgement":"We would like to thank Marco Sealey Cardona, PhD for help with the mouse brain samples and acknowledge the financial support by 1669 Förderkreis of the University of Innsbruck, Austria Wirtschaftsservice (AWS), D. Swarovski KG and Tyrolean Science Fund (TWF)."},{"main_file_link":[{"url":"https://doi.org/10.1146/annurev-fluid-022421-011319","open_access":"1"}],"type":"journal_article","day":"01","citation":{"short":"C.J. Muller, D. Yang, G. Craig, T. Cronin, B. Fildier, J.O. Haerter, C. Hohenegger, B. Mapes, D. Randall, S. Shamekh, S.C. Sherwood, Annual Review of Fluid Mechanics 54 (2022) 133–157.","ieee":"C. J. Muller <i>et al.</i>, “Spontaneous aggregation of convective storms,” <i>Annual Review of Fluid Mechanics</i>, vol. 54. Annual Reviews, pp. 133–157, 2022.","ama":"Muller CJ, Yang D, Craig G, et al. Spontaneous aggregation of convective storms. <i>Annual Review of Fluid Mechanics</i>. 2022;54:133-157. doi:<a href=\"https://doi.org/10.1146/annurev-fluid-022421-011319\">10.1146/annurev-fluid-022421-011319</a>","ista":"Muller CJ, Yang D, Craig G, Cronin T, Fildier B, Haerter JO, Hohenegger C, Mapes B, Randall D, Shamekh S, Sherwood SC. 2022. Spontaneous aggregation of convective storms. Annual Review of Fluid Mechanics. 54, 133–157.","chicago":"Muller, Caroline J, Da Yang, George Craig, Timothy Cronin, Benjamin Fildier, Jan O. Haerter, Cathy Hohenegger, et al. “Spontaneous Aggregation of Convective Storms.” <i>Annual Review of Fluid Mechanics</i>. Annual Reviews, 2022. <a href=\"https://doi.org/10.1146/annurev-fluid-022421-011319\">https://doi.org/10.1146/annurev-fluid-022421-011319</a>.","apa":"Muller, C. J., Yang, D., Craig, G., Cronin, T., Fildier, B., Haerter, J. O., … Sherwood, S. C. (2022). Spontaneous aggregation of convective storms. <i>Annual Review of Fluid Mechanics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-fluid-022421-011319\">https://doi.org/10.1146/annurev-fluid-022421-011319</a>","mla":"Muller, Caroline J., et al. “Spontaneous Aggregation of Convective Storms.” <i>Annual Review of Fluid Mechanics</i>, vol. 54, Annual Reviews, 2022, pp. 133–57, doi:<a href=\"https://doi.org/10.1146/annurev-fluid-022421-011319\">10.1146/annurev-fluid-022421-011319</a>."},"doi":"10.1146/annurev-fluid-022421-011319","quality_controlled":"1","oa_version":"Published Version","intvolume":"        54","article_type":"original","abstract":[{"text":"Idealized simulations of the tropical atmosphere have predicted that clouds can spontaneously clump together in space, despite perfectly homogeneous settings. This phenomenon has been called self-aggregation, and it results in a state where a moist cloudy region with intense deep convective storms is surrounded by extremely dry subsiding air devoid of deep clouds. We review here the main findings from theoretical work and idealized models of this phenomenon, highlighting the physical processes believed to play a key role in convective self-aggregation. We also review the growing literature on the importance and implications of this phenomenon for the tropical atmosphere, notably, for the hydrological cycle and for precipitation extremes, in our current and in a warming climate.","lang":"eng"}],"volume":54,"title":"Spontaneous aggregation of convective storms","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2022-01-23T23:01:29Z","department":[{"_id":"CaMu"}],"publisher":"Annual Reviews","publication":"Annual Review of Fluid Mechanics","month":"01","isi":1,"external_id":{"isi":["000794152800006"]},"oa":1,"author":[{"full_name":"Muller, Caroline J","first_name":"Caroline J","orcid":"0000-0001-5836-5350","last_name":"Muller","id":"f978ccb0-3f7f-11eb-b193-b0e2bd13182b"},{"first_name":"Da","full_name":"Yang, Da","last_name":"Yang"},{"last_name":"Craig","full_name":"Craig, George","first_name":"George"},{"last_name":"Cronin","first_name":"Timothy","full_name":"Cronin, Timothy"},{"full_name":"Fildier, Benjamin","first_name":"Benjamin","last_name":"Fildier"},{"first_name":"Jan O.","full_name":"Haerter, Jan O.","last_name":"Haerter"},{"last_name":"Hohenegger","first_name":"Cathy","full_name":"Hohenegger, Cathy"},{"last_name":"Mapes","full_name":"Mapes, Brian","first_name":"Brian"},{"first_name":"David","full_name":"Randall, David","last_name":"Randall"},{"full_name":"Shamekh, Sara","first_name":"Sara","last_name":"Shamekh"},{"full_name":"Sherwood, Steven C.","first_name":"Steven C.","last_name":"Sherwood"}],"acknowledgement":"C.M. gratefully acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (Project CLUSTER, grant agreement 805041). She also thanks Grand Équipement National de Calcul Intensif (GENCI), France, for providing access to their computing platforms at Très Grand Centre de Calcul (TGCC). J.O.H. gratefully acknowledges funding from the Villum Foundation (grant 13168), the ERC under the Horizon 2020 research and innovation program (grant 771859), and the Novo Nordisk Foundation's Interdisciplinary Synergy Program (grant NNF19OC0057374). G.C. gratefully acknowledges the support of the transregional collaborative research center (SFB/TRR 165) “Waves to Weather” (http://www.wavestoweather.de) funded by the German Research Foundation (DFG). D.Y. is supported by a Packard Fellowship in Science and Engineering, the France–Berkeley Fund, Laboratory Directed Research and Development (LDRD) funding from the Lawrence Berkeley National Laboratory, and the US Department of Energy, Office of Science, Office of Biological and Environmental Research, Climate and Environmental Sciences Division, Regional and Global Climate Modeling Program under award DE-AC02-05CH11231.","status":"public","date_published":"2022-01-01T00:00:00Z","year":"2022","publication_identifier":{"eissn":["1545-4479"],"issn":["0066-4189"]},"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"133-157","ec_funded":1,"publication_status":"published","date_updated":"2023-10-03T10:51:07Z","project":[{"name":"organization of CLoUdS, and implications of Tropical  cyclones and for the Energetics of the tropics, in current and waRming climate","grant_number":"805041","_id":"629205d8-2b32-11ec-9570-e1356ff73576","call_identifier":"H2020"}],"_id":"10656"},{"publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"year":"2022","status":"public","date_published":"2022-01-24T00:00:00Z","ddc":["576"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","author":[{"first_name":"Himani","full_name":"Sachdeva, Himani","last_name":"Sachdeva"},{"id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","last_name":"Olusanya","orcid":"0000-0003-1971-8314","full_name":"Olusanya, Oluwafunmilola O","first_name":"Oluwafunmilola O"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H"}],"isi":1,"external_id":{"isi":["000745854300008"],"pmid":["35067097"]},"oa":1,"acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) (grant no. P-32896B).","_id":"10658","publication_status":"published","project":[{"name":"Causes and consequences of population fragmentation","grant_number":"P32896","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"}],"date_updated":"2025-05-26T09:05:09Z","file_date_updated":"2022-01-24T10:34:45Z","has_accepted_license":"1","publisher":"The Royal Society","file":[{"file_id":"10659","creator":"oolusany","date_updated":"2022-01-24T10:34:45Z","access_level":"open_access","file_name":"rstb.2021.0010.pdf","date_created":"2022-01-24T10:34:45Z","checksum":"04ca9e2f0e344d680b947f2457df8d0a","file_size":1845792,"relation":"main_file","content_type":"application/pdf"}],"month":"01","pmid":1,"publication":"Philosophical Transactions of the Royal Society B","volume":377,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’."}],"issue":"1846","article_number":"20210010","article_type":"original","intvolume":"       377","date_created":"2022-01-24T10:34:53Z","language":[{"iso":"eng"}],"department":[{"_id":"GradSch"},{"_id":"NiBa"}],"title":"Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity","day":"24","type":"journal_article","citation":{"mla":"Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846, 20210010, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>.","ista":"Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. 377(1846), 20210010.","chicago":"Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>.","apa":"Sachdeva, H., Olusanya, O. O., &#38; Barton, N. H. (2022). Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>","ama":"Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. 2022;377(1846). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>","ieee":"H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity,” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846. The Royal Society, 2022.","short":"H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the Royal Society B 377 (2022)."},"related_material":{"record":[{"status":"public","id":"14711","relation":"dissertation_contains"}],"link":[{"url":"https://doi.org/10.1101/2021.08.05.455207","relation":"earlier_version"}]},"oa_version":"Published Version","quality_controlled":"1","doi":"10.1098/rstb.2021.0010"},{"month":"01","file":[{"file_size":1540606,"checksum":"34f10bb2b0594189dcac24d13b691d52","content_type":"application/pdf","relation":"main_file","success":1,"file_id":"10708","access_level":"open_access","creator":"cchlebak","date_updated":"2022-01-31T13:16:05Z","date_created":"2022-01-31T13:16:05Z","file_name":"2022_GenomeBio_McCartney.pdf"}],"publication":"Genome Biology","file_date_updated":"2022-01-31T13:16:05Z","publisher":"Springer Nature","has_accepted_license":"1","_id":"10702","project":[{"name":"Improving estimation and prediction of common complex disease risk","grant_number":"PCEGP3_181181","_id":"9B8D11D6-BA93-11EA-9121-9846C619BF3A"}],"date_updated":"2023-08-02T14:05:13Z","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","year":"2022","publication_identifier":{"issn":["1474-7596"],"eissn":["1474-760X"]},"ddc":["570"],"date_published":"2022-01-17T00:00:00Z","status":"public","acknowledgement":"GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Genotyping and DNA methylation profiling of the GS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally (STRADL; Reference 104036/Z/14/Z). The DNA methylation data assayed for Generation Scotland was partially funded by a 2018 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (Ref: 27404; awardee: Dr David M Howard) and by a JMAS SIM fellowship from the Royal College of Physicians of Edinburgh (Awardee: Dr Heather C Whalley). LBC1936 MRI brain imaging was supported by Medical Research Council (MRC) grants [G0701120], [G1001245], [MR/M013111/1] and [MR/R024065/1]. Magnetic resonance image acquisition and analyses were conducted at the Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh (www.bric.ed.ac.uk) which is part of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) collaboration (www.sinapse.ac.uk) funded by the Scottish Funding Council and the Chief Scientist Office. This work was supported by the European Union Horizon 2020 (PHC.03.15, project No 666881), SVDs@Target, the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease [ref no. 16 CVD 05]. We thank the LBC1936 participants and team members who contributed to these studies. The LBC1936 is supported by Age UK (Disconnected Mind project, which supports S.E.H.), the Medical Research Council (G0701120, G1001245, MR/M013111/1, MR/R024065/1) and the University of Edinburgh. Methylation typing of LBC1936 was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. Genotyping was funded by the Biotechnology and Biological Sciences Research Council (BB/F019394/1). Proteomic analyses in LBC1936 were supported by the Age UK grant and NIH Grants R01AG054628 and R01AG05462802S1. M.V.H. is funded by the Row Fogo Charitable Trust (Grant no. BROD.FID3668413). J.M.W is supported by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimers Society and Alzheimers Research UK. R.F.H., E.L.S.C and D.A.G. are supported by funding from the Wellcome Trust 4 year PhD in Translational Neuroscience: training the next generation of basic neuroscientists to embrace clinical research [108890/Z/15/Z]. E.M.T.D. was supported by the National Institutes of Health (NIH) grants R01AG054628, R01MH120219, R01HD083613, P2CHD042849 and P30AG066614. S.R.C. was also supported by a National Institutes of Health (NIH) research grant R01AG054628 and is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 221890/Z/20/Z). D.L.Mc.C. and R.E.M. are supported by Alzheimers Research UK major project grant ARUK/PG2017B/10. R.E.M. is supported by Alzheimer’s Society major project grant AS-PG-19b-010. This research was funded in whole, or in part, by Wellcome [104036/Z/14/Z and 108890/Z/15/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.","oa":1,"author":[{"full_name":"McCartney, Daniel L.","first_name":"Daniel L.","last_name":"McCartney"},{"first_name":"Robert F.","full_name":"Hillary, Robert F.","last_name":"Hillary"},{"full_name":"Conole, Eleanor L.S.","first_name":"Eleanor L.S.","last_name":"Conole"},{"last_name":"Banos","full_name":"Banos, Daniel Trejo","first_name":"Daniel Trejo"},{"first_name":"Danni A.","full_name":"Gadd, Danni A.","last_name":"Gadd"},{"last_name":"Walker","first_name":"Rosie M.","full_name":"Walker, Rosie M."},{"first_name":"Cliff","full_name":"Nangle, Cliff","last_name":"Nangle"},{"last_name":"Flaig","first_name":"Robin","full_name":"Flaig, Robin"},{"first_name":"Archie","full_name":"Campbell, Archie","last_name":"Campbell"},{"last_name":"Murray","first_name":"Alison D.","full_name":"Murray, Alison D."},{"last_name":"Maniega","full_name":"Maniega, Susana Muñoz","first_name":"Susana Muñoz"},{"first_name":"María Del C.","full_name":"Valdés-Hernández, María Del C.","last_name":"Valdés-Hernández"},{"full_name":"Harris, Mathew A.","first_name":"Mathew A.","last_name":"Harris"},{"last_name":"Bastin","first_name":"Mark E.","full_name":"Bastin, Mark E."},{"first_name":"Joanna M.","full_name":"Wardlaw, Joanna M.","last_name":"Wardlaw"},{"last_name":"Harris","first_name":"Sarah E.","full_name":"Harris, Sarah E."},{"last_name":"Porteous","first_name":"David J.","full_name":"Porteous, David J."},{"last_name":"Tucker-Drob","full_name":"Tucker-Drob, Elliot M.","first_name":"Elliot M."},{"last_name":"McIntosh","full_name":"McIntosh, Andrew M.","first_name":"Andrew M."},{"first_name":"Kathryn L.","full_name":"Evans, Kathryn L.","last_name":"Evans"},{"full_name":"Deary, Ian J.","first_name":"Ian J.","last_name":"Deary"},{"first_name":"Simon R.","full_name":"Cox, Simon R.","last_name":"Cox"},{"orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"full_name":"Marioni, Riccardo E.","first_name":"Riccardo E.","last_name":"Marioni"}],"external_id":{"isi":["000744358300002"]},"isi":1,"oa_version":"Published Version","doi":"10.1186/s13059-021-02596-5","quality_controlled":"1","citation":{"ama":"McCartney DL, Hillary RF, Conole ELS, et al. Blood-based epigenome-wide analyses of cognitive abilities. <i>Genome Biology</i>. 2022;23(1). doi:<a href=\"https://doi.org/10.1186/s13059-021-02596-5\">10.1186/s13059-021-02596-5</a>","short":"D.L. McCartney, R.F. Hillary, E.L.S. Conole, D.T. Banos, D.A. Gadd, R.M. Walker, C. Nangle, R. Flaig, A. Campbell, A.D. Murray, S.M. Maniega, M.D.C. Valdés-Hernández, M.A. Harris, M.E. Bastin, J.M. Wardlaw, S.E. Harris, D.J. Porteous, E.M. Tucker-Drob, A.M. McIntosh, K.L. Evans, I.J. Deary, S.R. Cox, M.R. Robinson, R.E. Marioni, Genome Biology 23 (2022).","ieee":"D. L. McCartney <i>et al.</i>, “Blood-based epigenome-wide analyses of cognitive abilities,” <i>Genome Biology</i>, vol. 23, no. 1. Springer Nature, 2022.","apa":"McCartney, D. L., Hillary, R. F., Conole, E. L. S., Banos, D. T., Gadd, D. A., Walker, R. M., … Marioni, R. E. (2022). Blood-based epigenome-wide analyses of cognitive abilities. <i>Genome Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13059-021-02596-5\">https://doi.org/10.1186/s13059-021-02596-5</a>","ista":"McCartney DL, Hillary RF, Conole ELS, Banos DT, Gadd DA, Walker RM, Nangle C, Flaig R, Campbell A, Murray AD, Maniega SM, Valdés-Hernández MDC, Harris MA, Bastin ME, Wardlaw JM, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans KL, Deary IJ, Cox SR, Robinson MR, Marioni RE. 2022. Blood-based epigenome-wide analyses of cognitive abilities. Genome Biology. 23(1), 26.","chicago":"McCartney, Daniel L., Robert F. Hillary, Eleanor L.S. Conole, Daniel Trejo Banos, Danni A. Gadd, Rosie M. Walker, Cliff Nangle, et al. “Blood-Based Epigenome-Wide Analyses of Cognitive Abilities.” <i>Genome Biology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1186/s13059-021-02596-5\">https://doi.org/10.1186/s13059-021-02596-5</a>.","mla":"McCartney, Daniel L., et al. “Blood-Based Epigenome-Wide Analyses of Cognitive Abilities.” <i>Genome Biology</i>, vol. 23, no. 1, 26, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1186/s13059-021-02596-5\">10.1186/s13059-021-02596-5</a>."},"related_material":{"link":[{"relation":"earlier_version","url":"https://doi.org/10.1101/2021.05.24.21257698"}],"record":[{"relation":"research_data","id":"13072","status":"public"}]},"day":"17","type":"journal_article","department":[{"_id":"MaRo"}],"date_created":"2022-01-30T23:01:33Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"Blood-based epigenome-wide analyses of cognitive abilities","volume":23,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"text":"Background: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. Results: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm predictor explains ~4% of the variance, independently of a polygenic score, in two external cohorts. It also associates with circulating levels of neurology- and inflammation-related proteins, global brain imaging metrics, and regional cortical volumes. Conclusions: As sample sizes increase, the ability to assess cognitive function from DNAm data may be informative in settings where cognitive testing is unreliable or unavailable.","lang":"eng"}],"article_type":"original","article_number":"26","issue":"1","intvolume":"        23"},{"ec_funded":1,"publication_status":"published","project":[{"name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","call_identifier":"H2020","grant_number":"747687","_id":"260AA4E2-B435-11E9-9278-68D0E5697425"},{"grant_number":"724373","_id":"25FE9508-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Cellular navigation along spatial gradients"}],"date_updated":"2024-03-25T23:30:12Z","_id":"10703","oa":1,"isi":1,"author":[{"full_name":"Gaertner, Florian","first_name":"Florian","last_name":"Gaertner"},{"first_name":"Patricia","full_name":"Reis-Rodrigues, Patricia","last_name":"Reis-Rodrigues"},{"last_name":"De Vries","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","first_name":"Ingrid","full_name":"De Vries, Ingrid"},{"id":"4167FE56-F248-11E8-B48F-1D18A9856A87","last_name":"Hons","orcid":"0000-0002-6625-3348","full_name":"Hons, Miroslav","first_name":"Miroslav"},{"first_name":"Juan","full_name":"Aguilera, Juan","last_name":"Aguilera"},{"orcid":"0000-0003-4844-6311","full_name":"Riedl, Michael","first_name":"Michael","last_name":"Riedl","id":"3BE60946-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Leithner","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander F","full_name":"Leithner, Alexander F","orcid":"0000-0002-1073-744X"},{"orcid":"0000-0003-1671-393X","full_name":"Tasciyan, Saren","first_name":"Saren","last_name":"Tasciyan","id":"4323B49C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kopf, Aglaja","first_name":"Aglaja","orcid":"0000-0002-2187-6656","last_name":"Kopf","id":"31DAC7B6-F248-11E8-B48F-1D18A9856A87"},{"id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","first_name":"Jack","full_name":"Merrin, Jack","orcid":"0000-0001-5145-4609"},{"id":"39C5A68A-F248-11E8-B48F-1D18A9856A87","last_name":"Zheden","first_name":"Vanessa","full_name":"Zheden, Vanessa","orcid":"0000-0002-9438-4783"},{"orcid":"0000-0001-9735-5315","full_name":"Kaufmann, Walter","first_name":"Walter","last_name":"Kaufmann","id":"3F99E422-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","last_name":"Hauschild"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","orcid":"0000-0002-6620-9179","first_name":"Michael K","full_name":"Sixt, Michael K"}],"external_id":{"isi":["000768933800005"],"pmid":["34919802"]},"acknowledgement":"We thank N. Darwish-Miranda, F. Leite, F.P. Assen, and A. Eichner for advice and help with experiments. We thank J. Renkawitz, E. Kiermaier, A. Juanes Garcia, and M. Avellaneda for critical reading of the manuscript. We thank M. Driscoll for advice on fluorescent labeling of collagen gels. This research was supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Molecular Biology Services/Lab Support Facility (LSF)/Bioimaging Facility/Electron Microscopy Facility. This work was funded by grants from the European Research Council ( CoG 724373 ) and the Austrian Science Foundation (FWF) to M.S. F.G. received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 747687.","publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"year":"2022","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","status":"public","date_published":"2022-01-10T00:00:00Z","ddc":["570"],"page":"47-62.e9","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","pmid":1,"publication":"Developmental Cell","month":"01","publisher":"Cell Press ; Elsevier","scopus_import":"1","title":"WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues","date_created":"2022-01-30T23:01:33Z","language":[{"iso":"eng"}],"department":[{"_id":"MiSi"},{"_id":"EM-Fac"},{"_id":"NanoFab"},{"_id":"BjHo"}],"issue":"1","article_type":"original","intvolume":"        57","abstract":[{"text":"When crawling through the body, leukocytes often traverse tissues that are densely packed with extracellular matrix and other cells, and this raises the question: How do leukocytes overcome compressive mechanical loads? Here, we show that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness requires neither force sensing via the nucleus nor adhesive interactions with a substrate. Upon global compression of the cell body as well as local indentation of the plasma membrane, Wiskott-Aldrich syndrome protein (WASp) assembles into dot-like structures, providing activation platforms for Arp2/3 nucleated actin patches. These patches locally push against the external load, which can be obstructing collagen fibers or other cells, and thereby create space to facilitate forward locomotion. We show in vitro and in vivo that this WASp function is rate limiting for ameboid leukocyte migration in dense but not in loose environments and is required for trafficking through diverse tissues such as skin and lymph nodes.","lang":"eng"}],"tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"volume":57,"quality_controlled":"1","doi":"10.1016/j.devcel.2021.11.024","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S1534580721009497"}],"day":"10","type":"journal_article","citation":{"mla":"Gaertner, Florian, et al. “WASp Triggers Mechanosensitive Actin Patches to Facilitate Immune Cell Migration in Dense Tissues.” <i>Developmental Cell</i>, vol. 57, no. 1, Cell Press ; Elsevier, 2022, p. 47–62.e9, doi:<a href=\"https://doi.org/10.1016/j.devcel.2021.11.024\">10.1016/j.devcel.2021.11.024</a>.","apa":"Gaertner, F., Reis-Rodrigues, P., de Vries, I., Hons, M., Aguilera, J., Riedl, M., … Sixt, M. K. (2022). WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues. <i>Developmental Cell</i>. Cell Press ; Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2021.11.024\">https://doi.org/10.1016/j.devcel.2021.11.024</a>","ista":"Gaertner F, Reis-Rodrigues P, de Vries I, Hons M, Aguilera J, Riedl M, Leithner AF, Tasciyan S, Kopf A, Merrin J, Zheden V, Kaufmann W, Hauschild R, Sixt MK. 2022. WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues. Developmental Cell. 57(1), 47–62.e9.","chicago":"Gaertner, Florian, Patricia Reis-Rodrigues, Ingrid de Vries, Miroslav Hons, Juan Aguilera, Michael Riedl, Alexander F Leithner, et al. “WASp Triggers Mechanosensitive Actin Patches to Facilitate Immune Cell Migration in Dense Tissues.” <i>Developmental Cell</i>. Cell Press ; Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.devcel.2021.11.024\">https://doi.org/10.1016/j.devcel.2021.11.024</a>.","short":"F. Gaertner, P. Reis-Rodrigues, I. de Vries, M. Hons, J. Aguilera, M. Riedl, A.F. Leithner, S. Tasciyan, A. Kopf, J. Merrin, V. Zheden, W. Kaufmann, R. Hauschild, M.K. Sixt, Developmental Cell 57 (2022) 47–62.e9.","ieee":"F. Gaertner <i>et al.</i>, “WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues,” <i>Developmental Cell</i>, vol. 57, no. 1. Cell Press ; Elsevier, p. 47–62.e9, 2022.","ama":"Gaertner F, Reis-Rodrigues P, de Vries I, et al. WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues. <i>Developmental Cell</i>. 2022;57(1):47-62.e9. doi:<a href=\"https://doi.org/10.1016/j.devcel.2021.11.024\">10.1016/j.devcel.2021.11.024</a>"},"related_material":{"record":[{"relation":"dissertation_contains","id":"12726","status":"public"},{"id":"14530","status":"public","relation":"dissertation_contains"},{"status":"public","id":"12401","relation":"dissertation_contains"}]}},{"publication":"Inventiones Mathematicae","month":"05","file":[{"file_name":"2022_InventionesMahtematicae_Hausel.pdf","date_created":"2023-02-27T07:30:47Z","file_id":"12687","date_updated":"2023-02-27T07:30:47Z","creator":"dernst","access_level":"open_access","success":1,"relation":"main_file","content_type":"application/pdf","checksum":"a382ba75acebc9adfb8fe56247cb410e","file_size":1069538}],"publisher":"Springer Nature","has_accepted_license":"1","file_date_updated":"2023-02-27T07:30:47Z","date_updated":"2023-08-02T14:03:20Z","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"publication_status":"published","arxiv":1,"_id":"10704","acknowledgement":"We would like to thank Brian Collier, Davide Gaiotto, Peter Gothen, Jochen Heinloth, Daniel Huybrechts, Quoc Ho, Joel Kamnitzer, Gérard Laumon, Luca Migliorini, Alexander Minets, Brent Pym, Peng Shan, Carlos Simpson, András Szenes, Fernando R. Villegas, Richard Wentworth, Edward Witten and Kōta Yoshioka for interesting comments and discussions. Most of all we are grateful for a long list of very helpful comments by the referee. We would also like to thank the organizers of the Summer School on Higgs bundles in Hamburg in September 2018, where the authors and Richard Wentworth were giving lectures and where the work in this paper started by considering the mirror of the Lagrangian upward flows W+E investigated in [17]. The second author wishes to thank EPSRC and ICMAT for support. Open access funding provided by Institute of Science and Technology (IST Austria).","oa":1,"external_id":{"isi":["000745495400001"],"arxiv":["2101.08583"]},"isi":1,"author":[{"id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","last_name":"Hausel","first_name":"Tamás","full_name":"Hausel, Tamás"},{"last_name":"Hitchin","full_name":"Hitchin, Nigel","first_name":"Nigel"}],"article_processing_charge":"Yes (via OA deal)","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"893-989","ddc":["510"],"date_published":"2022-05-01T00:00:00Z","status":"public","publication_identifier":{"issn":["0020-9910"],"eissn":["1432-1297"]},"year":"2022","doi":"10.1007/s00222-021-01093-7","quality_controlled":"1","oa_version":"Published Version","related_material":{"link":[{"url":"https://ista.ac.at/en/news/the-tip-of-the-mathematical-iceberg/","description":"News on the ISTA Website","relation":"press_release"}]},"citation":{"mla":"Hausel, Tamás, and Nigel Hitchin. “Very Stable Higgs Bundles, Equivariant Multiplicity and Mirror Symmetry.” <i>Inventiones Mathematicae</i>, vol. 228, Springer Nature, 2022, pp. 893–989, doi:<a href=\"https://doi.org/10.1007/s00222-021-01093-7\">10.1007/s00222-021-01093-7</a>.","short":"T. Hausel, N. Hitchin, Inventiones Mathematicae 228 (2022) 893–989.","ieee":"T. Hausel and N. Hitchin, “Very stable Higgs bundles, equivariant multiplicity and mirror symmetry,” <i>Inventiones Mathematicae</i>, vol. 228. Springer Nature, pp. 893–989, 2022.","ama":"Hausel T, Hitchin N. Very stable Higgs bundles, equivariant multiplicity and mirror symmetry. <i>Inventiones Mathematicae</i>. 2022;228:893-989. doi:<a href=\"https://doi.org/10.1007/s00222-021-01093-7\">10.1007/s00222-021-01093-7</a>","ista":"Hausel T, Hitchin N. 2022. Very stable Higgs bundles, equivariant multiplicity and mirror symmetry. Inventiones Mathematicae. 228, 893–989.","apa":"Hausel, T., &#38; Hitchin, N. (2022). Very stable Higgs bundles, equivariant multiplicity and mirror symmetry. <i>Inventiones Mathematicae</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00222-021-01093-7\">https://doi.org/10.1007/s00222-021-01093-7</a>","chicago":"Hausel, Tamás, and Nigel Hitchin. “Very Stable Higgs Bundles, Equivariant Multiplicity and Mirror Symmetry.” <i>Inventiones Mathematicae</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00222-021-01093-7\">https://doi.org/10.1007/s00222-021-01093-7</a>."},"type":"journal_article","day":"01","title":"Very stable Higgs bundles, equivariant multiplicity and mirror symmetry","scopus_import":"1","department":[{"_id":"TaHa"}],"language":[{"iso":"eng"}],"date_created":"2022-01-30T23:01:34Z","intvolume":"       228","article_type":"original","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"We define and study the existence of very stable Higgs bundles on Riemann surfaces, how it implies a precise formula for the multiplicity of the very stable components of the global nilpotent cone and its relationship to mirror symmetry. The main ingredients are the Bialynicki-Birula theory of C∗-actions on semiprojective varieties, C∗ characters of indices of C∗-equivariant coherent sheaves, Hecke transformation for Higgs bundles, relative Fourier–Mukai transform along the Hitchin fibration, hyperholomorphic structures on universal bundles and cominuscule Higgs bundles."}],"volume":228},{"quality_controlled":"1","doi":"10.1016/j.tcb.2021.12.006","oa_version":"None","type":"journal_article","day":"01","citation":{"mla":"Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Rigidity Transitions in Development and Disease.” <i>Trends in Cell Biology</i>, vol. 32, no. 5, Cell Press, 2022, pp. P433-444, doi:<a href=\"https://doi.org/10.1016/j.tcb.2021.12.006\">10.1016/j.tcb.2021.12.006</a>.","ista":"Hannezo EB, Heisenberg C-PJ. 2022. Rigidity transitions in development and disease. Trends in Cell Biology. 32(5), P433-444.","chicago":"Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Rigidity Transitions in Development and Disease.” <i>Trends in Cell Biology</i>. Cell Press, 2022. <a href=\"https://doi.org/10.1016/j.tcb.2021.12.006\">https://doi.org/10.1016/j.tcb.2021.12.006</a>.","apa":"Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2022). Rigidity transitions in development and disease. <i>Trends in Cell Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.tcb.2021.12.006\">https://doi.org/10.1016/j.tcb.2021.12.006</a>","short":"E.B. Hannezo, C.-P.J. Heisenberg, Trends in Cell Biology 32 (2022) P433-444.","ieee":"E. B. Hannezo and C.-P. J. Heisenberg, “Rigidity transitions in development and disease,” <i>Trends in Cell Biology</i>, vol. 32, no. 5. Cell Press, pp. P433-444, 2022.","ama":"Hannezo EB, Heisenberg C-PJ. Rigidity transitions in development and disease. <i>Trends in Cell Biology</i>. 2022;32(5):P433-444. doi:<a href=\"https://doi.org/10.1016/j.tcb.2021.12.006\">10.1016/j.tcb.2021.12.006</a>"},"title":"Rigidity transitions in development and disease","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2022-01-30T23:01:34Z","department":[{"_id":"EdHa"},{"_id":"CaHe"}],"intvolume":"        32","issue":"5","article_type":"original","abstract":[{"lang":"eng","text":"Although rigidity and jamming transitions have been widely studied in physics and material science, their importance in a number of biological processes, including embryo development, tissue homeostasis, wound healing, and disease progression, has only begun to be recognized in the past few years. The hypothesis that biological systems can undergo rigidity/jamming transitions is attractive, as it would allow these systems to change their material properties rapidly and strongly. However, whether such transitions indeed occur in biological systems, how they are being regulated, and what their physiological relevance might be, is still being debated. Here, we review theoretical and experimental advances from the past few years, focusing on the regulation and role of potential tissue rigidity transitions in different biological processes."}],"volume":32,"pmid":1,"publication":"Trends in Cell Biology","month":"05","publisher":"Cell Press","publication_status":"published","date_updated":"2023-08-02T14:03:53Z","_id":"10705","isi":1,"external_id":{"pmid":["35058104"],"isi":["000795773900009"]},"author":[{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"acknowledgement":"We thank present and former members of the Heisenberg and Hannezo groups, in particular Bernat Corominas-Murtra and Nicoletta Petridou, for helpful discussions, and Claudia Flandoli for the artwork. We apologize for not being able to cite a number of highly relevant studies, to stay within the maximum allowed number of citations.","date_published":"2022-05-01T00:00:00Z","status":"public","publication_identifier":{"issn":["0962-8924"],"eissn":["1879-3088"]},"year":"2022","article_processing_charge":"No","page":"P433-444","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"doi":"10.1007/s40598-022-00198-y","quality_controlled":"1","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2110.10750"}],"related_material":{"link":[{"url":"https://conferences.cirm-math.fr/2383.html","relation":"earlier_version"}]},"citation":{"short":"M. Bialy, C. Fiorebe, A. Glutsyuk, M. Levi, A. Plakhov, S. Tabachnikov, Arnold Mathematical Journal 8 (2022) 411–422.","ama":"Bialy M, Fiorebe C, Glutsyuk A, Levi M, Plakhov A, Tabachnikov S. Open problems on billiards and geometric optics. <i>Arnold Mathematical Journal</i>. 2022;8:411-422. doi:<a href=\"https://doi.org/10.1007/s40598-022-00198-y\">10.1007/s40598-022-00198-y</a>","ieee":"M. Bialy, C. Fiorebe, A. Glutsyuk, M. Levi, A. Plakhov, and S. Tabachnikov, “Open problems on billiards and geometric optics,” <i>Arnold Mathematical Journal</i>, vol. 8. Springer Nature, pp. 411–422, 2022.","ista":"Bialy M, Fiorebe C, Glutsyuk A, Levi M, Plakhov A, Tabachnikov S. 2022. Open problems on billiards and geometric optics. Arnold Mathematical Journal. 8, 411–422.","apa":"Bialy, M., Fiorebe, C., Glutsyuk, A., Levi, M., Plakhov, A., &#38; Tabachnikov, S. (2022). Open problems on billiards and geometric optics. <i>Arnold Mathematical Journal</i>. Hybrid: Springer Nature. <a href=\"https://doi.org/10.1007/s40598-022-00198-y\">https://doi.org/10.1007/s40598-022-00198-y</a>","chicago":"Bialy, Misha, Corentin Fiorebe, Alexey Glutsyuk, Mark Levi, Alexander Plakhov, and Serge Tabachnikov. “Open Problems on Billiards and Geometric Optics.” <i>Arnold Mathematical Journal</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s40598-022-00198-y\">https://doi.org/10.1007/s40598-022-00198-y</a>.","mla":"Bialy, Misha, et al. “Open Problems on Billiards and Geometric Optics.” <i>Arnold Mathematical Journal</i>, vol. 8, Springer Nature, 2022, pp. 411–22, doi:<a href=\"https://doi.org/10.1007/s40598-022-00198-y\">10.1007/s40598-022-00198-y</a>."},"type":"journal_article","day":"01","title":"Open problems on billiards and geometric optics","scopus_import":"1","department":[{"_id":"VaKa"}],"language":[{"iso":"eng"}],"date_created":"2022-01-30T23:01:34Z","conference":{"name":"CIRM: Centre International de Rencontres Mathématiques","end_date":"2021-10-08","location":"Hybrid","start_date":"2021-10-04"},"intvolume":"         8","article_type":"original","volume":8,"abstract":[{"text":"This is a collection of problems composed by some participants of the workshop “Differential Geometry, Billiards, and Geometric Optics” that took place at CIRM on October 4–8, 2021.","lang":"eng"}],"publication":"Arnold Mathematical Journal","month":"10","publisher":"Springer Nature","date_updated":"2023-02-27T07:34:08Z","publication_status":"published","_id":"10706","arxiv":1,"oa":1,"external_id":{"arxiv":["2110.10750"]},"author":[{"last_name":"Bialy","full_name":"Bialy, Misha","first_name":"Misha"},{"id":"06619f18-9070-11eb-847d-d1ee780bd88b","last_name":"Fiorebe","first_name":"Corentin","full_name":"Fiorebe, Corentin"},{"last_name":"Glutsyuk","first_name":"Alexey","full_name":"Glutsyuk, Alexey"},{"first_name":"Mark","full_name":"Levi, Mark","last_name":"Levi"},{"first_name":"Alexander","full_name":"Plakhov, Alexander","last_name":"Plakhov"},{"full_name":"Tabachnikov, Serge","first_name":"Serge","last_name":"Tabachnikov"}],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"411-422","date_published":"2022-10-01T00:00:00Z","status":"public","publication_identifier":{"issn":["2199-6792"],"eissn":["2199-6806"]},"year":"2022"},{"publication_status":"published","project":[{"name":"Investigating the role of the novel major superfamily facilitator transporter family member MFSD1 in metastasis","_id":"2637E9C0-B435-11E9-9278-68D0E5697425","grant_number":"LSC16-021 "}],"date_updated":"2023-08-02T14:05:44Z","_id":"10712","external_id":{"isi":["000760618800001"]},"isi":1,"author":[{"last_name":"Roblek","id":"3047D808-F248-11E8-B48F-1D18A9856A87","full_name":"Roblek, Marko","first_name":"Marko","orcid":"0000-0001-9588-1389"},{"full_name":"Bicher, Julia","first_name":"Julia","last_name":"Bicher","id":"3CCBB46E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Merel","full_name":"van Gogh, Merel","last_name":"van Gogh"},{"last_name":"György","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","full_name":"György, Attila","first_name":"Attila","orcid":"0000-0002-1819-198X"},{"first_name":"Rita","full_name":"Seeböck, Rita","last_name":"Seeböck"},{"full_name":"Szulc, Bozena","first_name":"Bozena","last_name":"Szulc"},{"last_name":"Damme","first_name":"Markus","full_name":"Damme, Markus"},{"full_name":"Olczak, Mariusz","first_name":"Mariusz","last_name":"Olczak"},{"full_name":"Borsig, Lubor","first_name":"Lubor","last_name":"Borsig"},{"orcid":"0000-0001-8323-8353","first_name":"Daria E","full_name":"Siekhaus, Daria E","last_name":"Siekhaus","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87"}],"oa":1,"acknowledgement":"We thank M. Sixt, A. Leithner, and J. Alanko for helpful advice and the BioImaging Facility at IST Austria for technical support and assistance. We thank the Siekhaus Lab for the careful review of the manuscript and their input. MR and DS were funded by the NO Forschungs- und Bildungsges.m.b.H. (LS16-021) and IST core funding. MD was funded by Deutsche Forschungsgemeinschaft (DA 1785-1).","year":"2022","publication_identifier":{"issn":["2234-943X"]},"date_published":"2022-02-08T00:00:00Z","status":"public","ddc":["570"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"Yes (via OA deal)","publication":"Frontiers in Oncology","file":[{"file_id":"10751","access_level":"open_access","creator":"cchlebak","date_updated":"2022-02-08T13:26:40Z","date_created":"2022-02-08T13:26:40Z","file_name":"2022_FrontiersOncol_Roblek.pdf","file_size":6303227,"checksum":"63dfecf30c5bbf9408b3512bd603f78c","content_type":"application/pdf","relation":"main_file","success":1}],"month":"02","has_accepted_license":"1","publisher":"Frontiers","file_date_updated":"2022-02-08T13:26:40Z","scopus_import":"1","title":"The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis","date_created":"2022-02-01T10:33:50Z","language":[{"iso":"eng"}],"department":[{"_id":"DaSi"}],"article_type":"original","article_number":"777634","intvolume":"        12","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1 enabled higher levels of metastasis in a mouse model. We identified an increased migratory potential in MFSD1-/- tumor cells which was mediated by increased focal adhesion turn-over, reduced stability of mature inactive β1 integrin, and the resulting increased integrin activation index. We show that MFSD1 promoted recycling to the cell surface of endocytosed inactive β1 integrin and thereby protected β1 integrin from proteolytic degradation; this led to dampening of the integrin activation index. Furthermore, down-regulation of MFSD1 expression was observed during early steps of tumorigenesis and higher MFSD1 expression levels correlate with a better cancer patient prognosis. In sum, we describe a requirement for endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread."}],"acknowledged_ssus":[{"_id":"Bio"}],"volume":12,"doi":"10.3389/fonc.2022.777634","quality_controlled":"1","oa_version":"Published Version","type":"journal_article","day":"08","citation":{"mla":"Roblek, Marko, et al. “The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation Status and Thus Tumor Metastasis.” <i>Frontiers in Oncology</i>, vol. 12, 777634, Frontiers, 2022, doi:<a href=\"https://doi.org/10.3389/fonc.2022.777634\">10.3389/fonc.2022.777634</a>.","chicago":"Roblek, Marko, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck, Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, and Daria E Siekhaus. “The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation Status and Thus Tumor Metastasis.” <i>Frontiers in Oncology</i>. Frontiers, 2022. <a href=\"https://doi.org/10.3389/fonc.2022.777634\">https://doi.org/10.3389/fonc.2022.777634</a>.","apa":"Roblek, M., Bicher, J., van Gogh, M., György, A., Seeböck, R., Szulc, B., … Siekhaus, D. E. (2022). The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis. <i>Frontiers in Oncology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fonc.2022.777634\">https://doi.org/10.3389/fonc.2022.777634</a>","ista":"Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. 2022. The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis. Frontiers in Oncology. 12, 777634.","short":"M. Roblek, J. Bicher, M. van Gogh, A. György, R. Seeböck, B. Szulc, M. Damme, M. Olczak, L. Borsig, D.E. Siekhaus, Frontiers in Oncology 12 (2022).","ama":"Roblek M, Bicher J, van Gogh M, et al. The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis. <i>Frontiers in Oncology</i>. 2022;12. doi:<a href=\"https://doi.org/10.3389/fonc.2022.777634\">10.3389/fonc.2022.777634</a>","ieee":"M. Roblek <i>et al.</i>, “The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis,” <i>Frontiers in Oncology</i>, vol. 12. Frontiers, 2022."},"related_material":{"link":[{"relation":"confirmation","url":"https://ist.ac.at/en/news/suppressing-the-spread-of-tumors/","description":"News on IST Homepage"}]}},{"title":"Cell division in tissues enables macrophage infiltration","department":[{"_id":"DaSi"}],"date_created":"2022-02-01T11:23:18Z","language":[{"iso":"eng"}],"issue":"6591","article_type":"original","intvolume":"       376","volume":376,"tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"acknowledged_ssus":[{"_id":"Bio"}],"abstract":[{"text":"Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration through pores and tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by Drosophila macrophages requires division of an epithelial ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues. Invasion efficiency depends on division frequency, but reduction of adhesion strength allows macrophage entry independently of division. This work demonstrates that tissue dynamics can regulate cellular infiltration.","lang":"eng"}],"doi":"10.1126/science.abj0425","quality_controlled":"1","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2021.04.19.438995"}],"citation":{"mla":"Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” <i>Science</i>, vol. 376, no. 6591, American Association for the Advancement of Science, 2022, pp. 394–96, doi:<a href=\"https://doi.org/10.1126/science.abj0425\">10.1126/science.abj0425</a>.","chicago":"Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abj0425\">https://doi.org/10.1126/science.abj0425</a>.","ista":"Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division in tissues enables macrophage infiltration. Science. 376(6591), 394–396.","apa":"Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov, M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abj0425\">https://doi.org/10.1126/science.abj0425</a>","short":"M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov, F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022) 394–396.","ieee":"M. Akhmanova <i>et al.</i>, “Cell division in tissues enables macrophage infiltration,” <i>Science</i>, vol. 376, no. 6591. American Association for the Advancement of Science, pp. 394–396, 2022.","ama":"Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables macrophage infiltration. <i>Science</i>. 2022;376(6591):394-396. doi:<a href=\"https://doi.org/10.1126/science.abj0425\">10.1126/science.abj0425</a>"},"type":"journal_article","day":"22","project":[{"name":"Modeling epithelial tissue mechanics during cell invasion","call_identifier":"FWF","_id":"264CBBAC-B435-11E9-9278-68D0E5697425","grant_number":"M02379"}],"date_updated":"2023-08-02T14:06:15Z","publication_status":"published","_id":"10713","acknowledgement":"We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly strains. This work was supported by a grant from the Austrian Science Fund FWF: Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST Austria to D.S. and EMBL to S.D.R.","author":[{"first_name":"Maria","full_name":"Akhmanova, Maria","orcid":"0000-0003-1522-3162","id":"3425EC26-F248-11E8-B48F-1D18A9856A87","last_name":"Akhmanova"},{"first_name":"Shamsi","full_name":"Emtenani, Shamsi","orcid":"0000-0001-6981-6938","id":"49D32318-F248-11E8-B48F-1D18A9856A87","last_name":"Emtenani"},{"first_name":"Daniel","full_name":"Krueger, Daniel","last_name":"Krueger"},{"id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","last_name":"György","orcid":"0000-0002-1819-198X","first_name":"Attila","full_name":"György, Attila"},{"full_name":"Pereira Guarda, Mariana","first_name":"Mariana","id":"6de81d9d-e2f2-11eb-945a-af8bc2a60b26","last_name":"Pereira Guarda"},{"last_name":"Vlasov","first_name":"Mikhail","full_name":"Vlasov, Mikhail"},{"last_name":"Vlasov","first_name":"Fedor","full_name":"Vlasov, Fedor"},{"first_name":"Andrei","full_name":"Akopian, Andrei","last_name":"Akopian"},{"id":"2F064CFE-F248-11E8-B48F-1D18A9856A87","last_name":"Ratheesh","full_name":"Ratheesh, Aparna","first_name":"Aparna"},{"last_name":"De Renzis","first_name":"Stefano","full_name":"De Renzis, Stefano"},{"first_name":"Daria E","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","last_name":"Siekhaus"}],"external_id":{"isi":["000788553700039"],"pmid":["35446632"]},"oa":1,"isi":1,"page":"394-396","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","publication_identifier":{"issn":["0036-8075"]},"year":"2022","date_published":"2022-04-22T00:00:00Z","status":"public","publication":"Science","pmid":1,"month":"04","publisher":"American Association for the Advancement of Science"},{"abstract":[{"text":"Ribosomal defects perturb stem cell differentiation, causing diseases called ribosomopathies. How ribosome levels control stem cell differentiation is not fully known. Here, we discovered three RNA helicases are required for ribosome biogenesis and for Drosophila oogenesis. Loss of these helicases, which we named Aramis, Athos and Porthos, lead to aberrant stabilization of p53, cell cycle arrest and stalled GSC differentiation. Unexpectedly, Aramis is required for efficient translation of a cohort of mRNAs containing a 5’-Terminal-Oligo-Pyrimidine (TOP)-motif, including mRNAs that encode ribosomal proteins and a conserved p53 inhibitor, Novel Nucleolar protein 1 (Non1). The TOP-motif co-regulates the translation of growth-related mRNAs in mammals. As in mammals, the La-related protein co-regulates the translation of TOP-motif containing RNAs during Drosophila oogenesis. Thus, a previously unappreciated TOP-motif in Drosophila responds to reduced ribosome biogenesis to co-regulate the translation of ribosomal proteins and a p53 repressor, thus coupling ribosome biogenesis to GSC differentiation.","lang":"eng"}],"tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"volume":57,"intvolume":"        57","issue":"7","article_type":"original","language":[{"iso":"eng"}],"date_created":"2022-02-01T13:15:05Z","department":[{"_id":"DaSi"}],"title":"A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis","scopus_import":"1","day":"11","type":"journal_article","citation":{"mla":"Martin, Elliot T., et al. “A Translation Control Module Coordinates Germline Stem Cell Differentiation with Ribosome Biogenesis during Drosophila Oogenesis.” <i>Developmental Cell</i>, vol. 57, no. 7, Elsevier, 2022, p. 883–900.e10, doi:<a href=\"https://doi.org/10.1016/j.devcel.2022.03.005\">10.1016/j.devcel.2022.03.005</a>.","chicago":"Martin, Elliot T., Patrick Blatt, Elaine Ngyuen, Roni Lahr, Sangeetha Selvam, Hyun Ah M. Yoon, Tyler Pocchiari, et al. “A Translation Control Module Coordinates Germline Stem Cell Differentiation with Ribosome Biogenesis during Drosophila Oogenesis.” <i>Developmental Cell</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.devcel.2022.03.005\">https://doi.org/10.1016/j.devcel.2022.03.005</a>.","ista":"Martin ET, Blatt P, Ngyuen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani S, Siekhaus DE, Berman A, Fuchs G, Rangan P. 2022. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Developmental Cell. 57(7), 883–900.e10.","apa":"Martin, E. T., Blatt, P., Ngyuen, E., Lahr, R., Selvam, S., Yoon, H. A. M., … Rangan, P. (2022). A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2022.03.005\">https://doi.org/10.1016/j.devcel.2022.03.005</a>","ieee":"E. T. Martin <i>et al.</i>, “A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis,” <i>Developmental Cell</i>, vol. 57, no. 7. Elsevier, p. 883–900.e10, 2022.","ama":"Martin ET, Blatt P, Ngyuen E, et al. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. <i>Developmental Cell</i>. 2022;57(7):883-900.e10. doi:<a href=\"https://doi.org/10.1016/j.devcel.2022.03.005\">10.1016/j.devcel.2022.03.005</a>","short":"E.T. Martin, P. Blatt, E. Ngyuen, R. Lahr, S. Selvam, H.A.M. Yoon, T. Pocchiari, S. Emtenani, D.E. Siekhaus, A. Berman, G. Fuchs, P. Rangan, Developmental Cell 57 (2022) 883–900.e10."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2021.04.04.438367"}],"oa_version":"Preprint","doi":"10.1016/j.devcel.2022.03.005","quality_controlled":"1","status":"public","date_published":"2022-04-11T00:00:00Z","publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"year":"2022","article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"883-900.e10","isi":1,"external_id":{"isi":["000789021800005"]},"oa":1,"author":[{"full_name":"Martin, Elliot T.","first_name":"Elliot T.","last_name":"Martin"},{"last_name":"Blatt","full_name":"Blatt, Patrick","first_name":"Patrick"},{"full_name":"Ngyuen, Elaine","first_name":"Elaine","last_name":"Ngyuen"},{"full_name":"Lahr, Roni","first_name":"Roni","last_name":"Lahr"},{"full_name":"Selvam, Sangeetha","first_name":"Sangeetha","last_name":"Selvam"},{"full_name":"Yoon, Hyun Ah M.","first_name":"Hyun Ah M.","last_name":"Yoon"},{"last_name":"Pocchiari","first_name":"Tyler","full_name":"Pocchiari, Tyler"},{"last_name":"Emtenani","id":"49D32318-F248-11E8-B48F-1D18A9856A87","first_name":"Shamsi","full_name":"Emtenani, Shamsi","orcid":"0000-0001-6981-6938"},{"first_name":"Daria E","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353","last_name":"Siekhaus","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Berman","full_name":"Berman, Andrea","first_name":"Andrea"},{"full_name":"Fuchs, Gabriele","first_name":"Gabriele","last_name":"Fuchs"},{"last_name":"Rangan","full_name":"Rangan, Prashanth","first_name":"Prashanth"}],"acknowledgement":"We are grateful to all members of the Rangan and Fuchs labs for their discussion and comments on the manuscript. We also thanks Dr. Sammons, Dr. Marlow, Life Science Editors, for their thoughts and comments the manuscript Additionally, we thank the Bloomington Stock Center, the Vienna Drosophila Resource Center, the BDGP Gene Disruption Project, and Flybase for fly stocks, reagents, and other resources. P.R. is funded by the NIH/NIGMS (R01GM111779-06 and RO1GM135628-01), G.F. is funded by NSF MCB-2047629 and NIH RO3 AI144839, D.E.S. was funded by Marie Curie CIG 334077/IRTIM and the Austrian Science Fund (FWF) grant ASI_FWF01_P29638S, and A.B is funded by NIH R01GM116889 and American Cancer Society RSG-17-197-01-RMC.","_id":"10714","publication_status":"published","ec_funded":1,"date_updated":"2023-08-02T14:07:13Z","project":[{"name":"Investigating the role of transporters in invasive migration through junctions","call_identifier":"FP7","_id":"2536F660-B435-11E9-9278-68D0E5697425","grant_number":"334077"},{"name":"Drosophila TNFa´s Funktion in Immunzellen","_id":"253B6E48-B435-11E9-9278-68D0E5697425","grant_number":"P29638","call_identifier":"FWF"}],"publisher":"Elsevier","month":"04","publication":"Developmental Cell"},{"pmid":1,"publication":"Journal of Experimental Botany","month":"04","publisher":"Oxford Academic","publication_status":"published","ec_funded":1,"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"date_updated":"2023-08-02T14:07:58Z","_id":"10717","isi":1,"oa":1,"author":[{"last_name":"Wang","full_name":"Wang, R","first_name":"R"},{"full_name":"Himschoot, E","first_name":"E","last_name":"Himschoot"},{"first_name":"M","full_name":"Grenzi, M","last_name":"Grenzi"},{"last_name":"Chen","full_name":"Chen, J","first_name":"J"},{"last_name":"Safi","full_name":"Safi, A","first_name":"A"},{"last_name":"Krebs","first_name":"M","full_name":"Krebs, M"},{"full_name":"Schumacher, K","first_name":"K","last_name":"Schumacher"},{"last_name":"Nowack","full_name":"Nowack, MK","first_name":"MK"},{"full_name":"Moeder, W","first_name":"W","last_name":"Moeder"},{"last_name":"Yoshioka","full_name":"Yoshioka, K","first_name":"K"},{"first_name":"D","full_name":"Van Damme, D","last_name":"Van Damme"},{"last_name":"De Smet","full_name":"De Smet, I","first_name":"I"},{"full_name":"Geelen, D","first_name":"D","last_name":"Geelen"},{"last_name":"Beeckman","full_name":"Beeckman, T","first_name":"T"},{"full_name":"Friml, Jiří","first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Costa","full_name":"Costa, A","first_name":"A"},{"first_name":"S","full_name":"Vanneste, S","last_name":"Vanneste"}],"external_id":{"isi":["000764220900001"],"pmid":["35085386"]},"acknowledgement":"We thank Joerg Kudla (WWU Munster, Germany), Petra Dietrich (F.A. University of Erlangen-Nurnberg, Germany) for sharing published materials, and NASC for providing seeds. We thank Veronique Storme for help with the statistical analyses. Part of the imaging analysis was carried out at NOLIMITS, an advanced imaging facility established by the University of Milan.\r\nThis work was supported by grants of the China Scholarship Council (CSC) to RW and JC; Fonds Wetenschappelijk Onderzoek (FWO) to TB and (G002220N) SV; the special research fund of Ghent University to EH; the Deutsche Forschungsgemeinschaft (DFG) through Grants within FOR964 (MK and KS); Piano di Sviluppo di Ateneo 2019 (University of Milan) to AC; the European Research Council (ERC) T-Rex project 682436 to DVD; the ERC ETAP project 742985 to JF, and by a PhD fellowship from the University of Milan to MG.","year":"2022","publication_identifier":{"issn":["0022-0957"],"eissn":["1460-2431"]},"date_published":"2022-04-18T00:00:00Z","status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","doi":"10.1093/jxb/erac019","quality_controlled":"1","oa_version":"Submitted Version","main_file_link":[{"url":"https://biblio.ugent.be/publication/8738721","open_access":"1"}],"type":"journal_article","day":"18","citation":{"mla":"Wang, R., et al. “Auxin Analog-Induced Ca2+ Signaling Is Independent of Inhibition of Endosomal Aggregation in Arabidopsis Roots.” <i>Journal of Experimental Botany</i>, vol. 73, no. 8, erac019, Oxford Academic, 2022, doi:<a href=\"https://doi.org/10.1093/jxb/erac019\">10.1093/jxb/erac019</a>.","apa":"Wang, R., Himschoot, E., Grenzi, M., Chen, J., Safi, A., Krebs, M., … Vanneste, S. (2022). Auxin analog-induced Ca2+ signaling is independent of inhibition of endosomal aggregation in Arabidopsis roots. <i>Journal of Experimental Botany</i>. Oxford Academic. <a href=\"https://doi.org/10.1093/jxb/erac019\">https://doi.org/10.1093/jxb/erac019</a>","ista":"Wang R, Himschoot E, Grenzi M, Chen J, Safi A, Krebs M, Schumacher K, Nowack M, Moeder W, Yoshioka K, Van Damme D, De Smet I, Geelen D, Beeckman T, Friml J, Costa A, Vanneste S. 2022. Auxin analog-induced Ca2+ signaling is independent of inhibition of endosomal aggregation in Arabidopsis roots. Journal of Experimental Botany. 73(8), erac019.","chicago":"Wang, R, E Himschoot, M Grenzi, J Chen, A Safi, M Krebs, K Schumacher, et al. “Auxin Analog-Induced Ca2+ Signaling Is Independent of Inhibition of Endosomal Aggregation in Arabidopsis Roots.” <i>Journal of Experimental Botany</i>. Oxford Academic, 2022. <a href=\"https://doi.org/10.1093/jxb/erac019\">https://doi.org/10.1093/jxb/erac019</a>.","ama":"Wang R, Himschoot E, Grenzi M, et al. Auxin analog-induced Ca2+ signaling is independent of inhibition of endosomal aggregation in Arabidopsis roots. <i>Journal of Experimental Botany</i>. 2022;73(8). doi:<a href=\"https://doi.org/10.1093/jxb/erac019\">10.1093/jxb/erac019</a>","ieee":"R. Wang <i>et al.</i>, “Auxin analog-induced Ca2+ signaling is independent of inhibition of endosomal aggregation in Arabidopsis roots,” <i>Journal of Experimental Botany</i>, vol. 73, no. 8. Oxford Academic, 2022.","short":"R. Wang, E. Himschoot, M. Grenzi, J. Chen, A. Safi, M. Krebs, K. Schumacher, M. Nowack, W. Moeder, K. Yoshioka, D. Van Damme, I. De Smet, D. Geelen, T. Beeckman, J. Friml, A. Costa, S. Vanneste, Journal of Experimental Botany 73 (2022)."},"scopus_import":"1","title":"Auxin analog-induced Ca2+ signaling is independent of inhibition of endosomal aggregation in Arabidopsis roots","date_created":"2022-02-03T09:19:01Z","language":[{"iso":"eng"}],"department":[{"_id":"JiFr"}],"article_number":"erac019","issue":"8","article_type":"original","intvolume":"        73","abstract":[{"text":"Much of what we know about the role of auxin in plant development derives from exogenous manipulations of auxin distribution and signaling, using inhibitors, auxins and auxin analogs. In this context, synthetic auxin analogs, such as 1-Naphtalene Acetic Acid (1-NAA), are often favored over the endogenous auxin indole-3-acetic acid (IAA), in part due to their higher stability. While such auxin analogs have proven to be instrumental to reveal the various faces of auxin, they display in some cases distinct bioactivities compared to IAA. Here, we focused on the effect of auxin analogs on the accumulation of PIN proteins in Brefeldin A-sensitive endosomal aggregations (BFA bodies), and the correlation with the ability to elicit Ca 2+ responses. For a set of commonly used auxin analogs, we evaluated if auxin-analog induced Ca 2+ signaling inhibits PIN accumulation. Not all auxin analogs elicited a Ca 2+ response, and their differential ability to elicit Ca 2+ responses correlated partially with their ability to inhibit BFA-body formation. However, in tir1/afb and cngc14, 1-NAA-induced Ca 2+ signaling was strongly impaired, yet 1-NAA still could inhibit PIN accumulation in BFA bodies. This demonstrates that TIR1/AFB-CNGC14-dependent Ca 2+ signaling does not inhibit BFA body formation in Arabidopsis roots.","lang":"eng"}],"volume":73},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1111/jipb.13225"}],"citation":{"chicago":"Yu, Z, F Zhang, Jiří Friml, and Z Ding. “Auxin Signaling: Research Advances over the Past 30 Years.” <i>Journal of Integrative Plant Biology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/jipb.13225\">https://doi.org/10.1111/jipb.13225</a>.","ista":"Yu Z, Zhang F, Friml J, Ding Z. 2022. Auxin signaling: Research advances over the past 30 years. Journal of Integrative Plant Biology. 64(2), 371–392.","apa":"Yu, Z., Zhang, F., Friml, J., &#38; Ding, Z. (2022). Auxin signaling: Research advances over the past 30 years. <i>Journal of Integrative Plant Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jipb.13225\">https://doi.org/10.1111/jipb.13225</a>","ama":"Yu Z, Zhang F, Friml J, Ding Z. Auxin signaling: Research advances over the past 30 years. <i>Journal of Integrative Plant Biology</i>. 2022;64(2):371-392. doi:<a href=\"https://doi.org/10.1111/jipb.13225\">10.1111/jipb.13225</a>","short":"Z. Yu, F. Zhang, J. Friml, Z. Ding, Journal of Integrative Plant Biology 64 (2022) 371–392.","ieee":"Z. Yu, F. Zhang, J. Friml, and Z. Ding, “Auxin signaling: Research advances over the past 30 years,” <i>Journal of Integrative Plant Biology</i>, vol. 64, no. 2. Wiley, pp. 371–392, 2022.","mla":"Yu, Z., et al. “Auxin Signaling: Research Advances over the Past 30 Years.” <i>Journal of Integrative Plant Biology</i>, vol. 64, no. 2, Wiley, 2022, pp. 371–92, doi:<a href=\"https://doi.org/10.1111/jipb.13225\">10.1111/jipb.13225</a>."},"day":"01","type":"journal_article","quality_controlled":"1","doi":"10.1111/jipb.13225","oa_version":"Published Version","intvolume":"        64","issue":"2","article_type":"review","abstract":[{"lang":"eng","text":"Auxin, one of the first identified and most widely studied phytohormones, has been and will remain a hot topic in plant biology. After more than a century of passionate exploration, the mysteries of its synthesis, transport, signaling, and metabolism have largely been unlocked. Due to the rapid development of new technologies, new methods, and new genetic materials, the study of auxin has entered the fast lane over the past 30 years. Here, we highlight advances in understanding auxin signaling, including auxin perception, rapid auxin responses, TRANSPORT INHIBITOR RESPONSE 1 and AUXIN SIGNALING F-boxes (TIR1/AFBs)-mediated transcriptional and non-transcriptional branches, and the epigenetic regulation of auxin signaling. We also focus on feedback inhibition mechanisms that prevent the over-amplification of auxin signals. In addition, we cover the TRANSMEMBRANE KINASEs (TMKs)-mediated non-canonical signaling, which converges with TIR1/AFBs-mediated transcriptional regulation to coordinate plant growth and development. The identification of additional auxin signaling components and their regulation will continue to open new avenues of research in this field, leading to an increasingly deeper, more comprehensive understanding of how auxin signals are interpreted at the cellular level to regulate plant growth and development."}],"volume":64,"title":"Auxin signaling: Research advances over the past 30 years","scopus_import":"1","department":[{"_id":"JiFr"}],"language":[{"iso":"eng"}],"date_created":"2022-02-03T09:52:59Z","publisher":"Wiley","publication":"Journal of Integrative Plant Biology","pmid":1,"month":"02","acknowledgement":"This research was financially supported by the National Natural Science Foundation of China and the Israel Science Foundation (NSFC-ISF; 32061143005), National Natural Science Foundation of China (32000225), Natural Science Foundation of Shandong Province (ZR2020QC036), and China Postdoctoral Science Foundation (2020M682165).\r\n","external_id":{"pmid":["35018726"],"isi":["000761281200011"]},"isi":1,"author":[{"first_name":"Z","full_name":"Yu, Z","last_name":"Yu"},{"first_name":"F","full_name":"Zhang, F","last_name":"Zhang"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","first_name":"Jiří"},{"last_name":"Ding","full_name":"Ding, Z","first_name":"Z"}],"oa":1,"article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"371-392","status":"public","date_published":"2022-02-01T00:00:00Z","publication_identifier":{"eissn":["1744-7909"],"issn":["1672-9072"]},"year":"2022","date_updated":"2023-08-02T14:08:30Z","publication_status":"published","_id":"10719"},{"oa":1,"author":[{"full_name":"Metzler, Sina","first_name":"Sina","orcid":"0000-0002-9547-2494","id":"48204546-F248-11E8-B48F-1D18A9856A87","last_name":"Metzler"}],"status":"public","date_published":"2022-02-07T00:00:00Z","ddc":["570"],"publication_identifier":{"issn":["2663-337X"]},"year":"2022","article_processing_charge":"No","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ec_funded":1,"publication_status":"published","date_updated":"2023-09-07T13:43:23Z","project":[{"name":"Epidemics in ant societies on a chip","grant_number":"771402","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"_id":"10727","has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","file_date_updated":"2023-02-04T23:30:03Z","supervisor":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","orcid":"0000-0002-2193-3868","first_name":"Sylvia","full_name":"Cremer, Sylvia"}],"file":[{"embargo_to":"open_access","file_size":6757886,"checksum":"47ba18bb270dd6cc266e0a3f7c69d0e4","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"source_file","access_level":"closed","date_updated":"2023-02-03T23:30:03Z","creator":"smetzler","file_id":"10728","date_created":"2022-02-04T15:36:12Z","file_name":"Thesis_Sina_Metzler.docx"},{"relation":"main_file","content_type":"application/pdf","checksum":"f3ec07d5d6b20ae6e46bfeedebce9027","file_size":6314921,"date_created":"2022-02-04T15:36:43Z","file_name":"Thesis_Sina_Metzler_A2.pdf","embargo":"2023-02-02","file_id":"10730","creator":"smetzler","date_updated":"2023-02-03T23:30:03Z","access_level":"open_access"},{"content_type":"application/pdf","relation":"main_file","file_size":6882557,"checksum":"dedd14b7be7a75d63018dbfc68dd8113","date_created":"2022-02-07T10:35:02Z","file_name":"Thesis_Sina_Metzler_print.pdf","embargo":"2023-02-02","file_id":"10742","access_level":"open_access","date_updated":"2023-02-04T23:30:03Z","creator":"smetzler"}],"month":"02","degree_awarded":"PhD","abstract":[{"lang":"eng","text":"Social insects are a common model to study disease dynamics in social animals. Even though pathogens should thrive in social insect colonies as the hosts engage in frequent social interactions, are closely related and live in a pathogen-rich environment, disease outbreaks are rare. This is because social insects have evolved mechanisms to keep pathogens at bay – and fight disease as a collective. Social insect colonies are often viewed as “superorganisms” with division of labor between reproductive “germ-like” queens and males and “somatic” workers, which together form an interdependent reproductive unit that parallels a multicellular body. Superorganisms possess a “social immune system” that comprises of collective disease defenses performed by the workers - summarized as “social immunity”. In social groups immunization (reduced susceptibility to a parasite upon secondary exposure to the same parasite) can e.g. be triggered by social interactions (“social immunization”). Social immunization can be caused by (i) asymptomatic low-level infections that are acquired during caregiving to a contagious individual that can give an immune boost, which can induce protection upon later encounter with the same pathogen (active immunization) or (ii) by transfer of immune effectors between individuals (passive immunization).\r\nIn the second chapter, I built up on a study that I co-authored that found that low-level infections can not only be protective, but also be costly and make the host more susceptible to detrimental superinfections after contact to a very dissimilar pathogen. I here now tested different degrees of phylogenetically-distant fungal strains of M. brunneum and M. robertsii in L. neglectus and can describe the occurrence of cross-protection of social immunization if the first and second pathogen are from the same level. Interestingly, low-level infections only provided protection when the first strain was less virulent than the second strain and elicited higher immune gene expression.\r\nIn the third and fourth chapters, I expanded on the role of social immunity in sexual selection, a so far unstudied field. I used the fungus Metarhizium robertsii and the ant Cardiocondyla obscurior as a model, as in this species mating occurs in the presence of workers and can be studied under laboratory conditions. Before males mate with virgin queens in the nest they engage in fierce combat over the access to their mating partners.\r\nFirst, I focused on male-male competition in the third chapter and found that fighting with a contagious male is costly as it can lead to contamination of the rival, but that workers can decrease the risk of disease contraction by performing sanitary care.\r\nIn the fourth chapter, I studied the effect of fungal infection on survival and mating success of sexuals (freshly emerged queens and males) and found that worker-performed sanitary care can buffer the negative effect that a pathogenic contagion would have on sexuals by spore removal from the exposed individuals. When social immunity was prevented and queens could contract spores from their mating partner, very low dosages led to negative consequences: their lifespan was reduced and they produced fewer offspring with poor immunocompetence compared to healthy queens. Interestingly, cohabitation with a late-stage infected male where no spore transfer was possible had a positive effect on offspring immunity – male offspring of mothers that apparently perceived an infected partner in their vicinity reacted more sensitively to fungal challenge than male offspring without paternal pathogen history."}],"acknowledged_ssus":[{"_id":"LifeSc"}],"title":"Pathogen-mediated sexual selection and immunization in ant colonies","alternative_title":["ISTA Thesis"],"language":[{"iso":"eng"}],"date_created":"2022-02-04T15:45:12Z","department":[{"_id":"GradSch"},{"_id":"SyCr"}],"day":"07","type":"dissertation","citation":{"apa":"Metzler, S. (2022). <i>Pathogen-mediated sexual selection and immunization in ant colonies</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:10727\">https://doi.org/10.15479/AT:ISTA:10727</a>","ista":"Metzler S. 2022. Pathogen-mediated sexual selection and immunization in ant colonies. Institute of Science and Technology Austria.","chicago":"Metzler, Sina. “Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:10727\">https://doi.org/10.15479/AT:ISTA:10727</a>.","ieee":"S. Metzler, “Pathogen-mediated sexual selection and immunization in ant colonies,” Institute of Science and Technology Austria, 2022.","ama":"Metzler S. Pathogen-mediated sexual selection and immunization in ant colonies. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10727\">10.15479/AT:ISTA:10727</a>","short":"S. Metzler, Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies, Institute of Science and Technology Austria, 2022.","mla":"Metzler, Sina. <i>Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10727\">10.15479/AT:ISTA:10727</a>."},"doi":"10.15479/AT:ISTA:10727","oa_version":"Published Version"}]