[{"scopus_import":1,"abstract":[{"text":"Although the equations governing fluid flow are well known, there are no analytical expressions that describe the complexity of turbulent motion. A recent proposition is that in analogy to low dimensional chaotic systems, turbulence is organized around unstable solutions of the governing equations which provide the building blocks of the disordered dynamics. We report the discovery of periodic solutions which just like intermittent turbulence are spatially localized and show that turbulent transients arise from one such solution branch.","lang":"eng"}],"day":"29","citation":{"ieee":"M. Avila, F. Mellibovsky, N. Roland, and B. Hof, “Streamwise-localized solutions at the onset of turbulence in pipe flow,” <i>Physical Review Letters</i>, vol. 110, no. 22. American Physical Society, 2013.","mla":"Avila, Marc, et al. “Streamwise-Localized Solutions at the Onset of Turbulence in Pipe Flow.” <i>Physical Review Letters</i>, vol. 110, no. 22, 224502, American Physical Society, 2013, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.110.224502\">10.1103/PhysRevLett.110.224502</a>.","apa":"Avila, M., Mellibovsky, F., Roland, N., &#38; Hof, B. (2013). Streamwise-localized solutions at the onset of turbulence in pipe flow. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.110.224502\">https://doi.org/10.1103/PhysRevLett.110.224502</a>","ama":"Avila M, Mellibovsky F, Roland N, Hof B. Streamwise-localized solutions at the onset of turbulence in pipe flow. <i>Physical Review Letters</i>. 2013;110(22). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.110.224502\">10.1103/PhysRevLett.110.224502</a>","chicago":"Avila, Marc, Fernando Mellibovsky, Nicolas Roland, and Björn Hof. “Streamwise-Localized Solutions at the Onset of Turbulence in Pipe Flow.” <i>Physical Review Letters</i>. American Physical Society, 2013. <a href=\"https://doi.org/10.1103/PhysRevLett.110.224502\">https://doi.org/10.1103/PhysRevLett.110.224502</a>.","ista":"Avila M, Mellibovsky F, Roland N, Hof B. 2013. Streamwise-localized solutions at the onset of turbulence in pipe flow. Physical Review Letters. 110(22), 224502.","short":"M. Avila, F. Mellibovsky, N. Roland, B. Hof, Physical Review Letters 110 (2013)."},"date_updated":"2021-01-12T07:00:05Z","publisher":"American Physical Society","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"224502","title":"Streamwise-localized solutions at the onset of turbulence in pipe flow","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1212.0230"}],"project":[{"_id":"25152F3A-B435-11E9-9278-68D0E5697425","grant_number":"306589","name":"Decoding the complexity of turbulence at its origin","call_identifier":"FP7"}],"status":"public","volume":110,"date_created":"2018-12-11T11:59:50Z","year":"2013","quality_controlled":"1","publication_status":"published","intvolume":"       110","oa":1,"publication":"Physical Review Letters","date_published":"2013-05-29T00:00:00Z","doi":"10.1103/PhysRevLett.110.224502","_id":"2834","month":"05","external_id":{"arxiv":["1212.0230"]},"arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","issue":"22","department":[{"_id":"BjHo"}],"ec_funded":1,"author":[{"full_name":"Avila, Marc","last_name":"Avila","first_name":"Marc"},{"full_name":"Mellibovsky, Fernando","last_name":"Mellibovsky","first_name":"Fernando"},{"first_name":"Nicolas","full_name":"Roland, Nicolas","last_name":"Roland"},{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn","last_name":"Hof","orcid":"0000-0003-2057-2754","full_name":"Hof, Björn"}],"oa_version":"Preprint","publist_id":"3965"},{"volume":162,"year":"2013","date_created":"2018-12-11T11:59:51Z","page":"965 - 976","status":"public","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668084/","open_access":"1"}],"title":"Root ultraviolet b-sensitive1/weak auxin response3 is essential for polar auxin transport in arabidopsis","pmid":1,"date_updated":"2021-01-12T07:00:05Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"American Society of Plant Biologists","day":"01","citation":{"ista":"Yu H, Karampelias M, Robert S, Peer W, Swarup R, Ye S, Ge L, Cohen J, Murphy A, Friml J, Estelle M. 2013. Root ultraviolet b-sensitive1/weak auxin response3 is essential for polar auxin transport in arabidopsis. Plant Physiology. 162(2), 965–976.","ama":"Yu H, Karampelias M, Robert S, et al. Root ultraviolet b-sensitive1/weak auxin response3 is essential for polar auxin transport in arabidopsis. <i>Plant Physiology</i>. 2013;162(2):965-976. doi:<a href=\"https://doi.org/10.1104/pp.113.217018\">10.1104/pp.113.217018</a>","apa":"Yu, H., Karampelias, M., Robert, S., Peer, W., Swarup, R., Ye, S., … Estelle, M. (2013). Root ultraviolet b-sensitive1/weak auxin response3 is essential for polar auxin transport in arabidopsis. <i>Plant Physiology</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1104/pp.113.217018\">https://doi.org/10.1104/pp.113.217018</a>","chicago":"Yu, Hong, Michael Karampelias, Stéphanie Robert, Wendy Peer, Ranjan Swarup, Songqing Ye, Lei Ge, et al. “Root Ultraviolet B-Sensitive1/Weak Auxin Response3 Is Essential for Polar Auxin Transport in Arabidopsis.” <i>Plant Physiology</i>. American Society of Plant Biologists, 2013. <a href=\"https://doi.org/10.1104/pp.113.217018\">https://doi.org/10.1104/pp.113.217018</a>.","short":"H. Yu, M. Karampelias, S. Robert, W. Peer, R. Swarup, S. Ye, L. Ge, J. Cohen, A. Murphy, J. Friml, M. Estelle, Plant Physiology 162 (2013) 965–976.","ieee":"H. Yu <i>et al.</i>, “Root ultraviolet b-sensitive1/weak auxin response3 is essential for polar auxin transport in arabidopsis,” <i>Plant Physiology</i>, vol. 162, no. 2. American Society of Plant Biologists, pp. 965–976, 2013.","mla":"Yu, Hong, et al. “Root Ultraviolet B-Sensitive1/Weak Auxin Response3 Is Essential for Polar Auxin Transport in Arabidopsis.” <i>Plant Physiology</i>, vol. 162, no. 2, American Society of Plant Biologists, 2013, pp. 965–76, doi:<a href=\"https://doi.org/10.1104/pp.113.217018\">10.1104/pp.113.217018</a>."},"abstract":[{"lang":"eng","text":"The phytohormone auxin regulates virtually every aspect of plant development. To identify new genes involved in auxin activity, a genetic screen was performed for Arabidopsis (Arabidopsis thaliana) mutants with altered expression of the auxin-responsive reporter DR5rev:GFP. One of the mutants recovered in the screen, designated as weak auxin response3 (wxr3), exhibits much lower DR5rev:GFP expression when treated with the synthetic auxin 2,4-dichlorophenoxyacetic acid and displays severe defects in root development. The wxr3 mutant decreases polar auxin transport and results in a disruption of the asymmetric auxin distribution. The levels of the auxin transporters AUXIN1 and PIN-FORMED are dramatically reduced in the wxr3 root tip. Molecular analyses demonstrate that WXR3 is ROOT ULTRAVIOLET B-SENSITIVE1 (RUS1), a member of the conserved Domain of Unknown Function647 protein family found in diverse eukaryotic organisms. Our data suggest that RUS1/WXR3 plays an essential role in the regulation of polar auxin transport by maintaining the proper level of auxin transporters on the plasma membrane."}],"scopus_import":1,"publist_id":"3964","oa_version":"Submitted Version","author":[{"last_name":"Yu","full_name":"Yu, Hong","first_name":"Hong"},{"last_name":"Karampelias","full_name":"Karampelias, Michael","first_name":"Michael"},{"full_name":"Robert, Stéphanie","last_name":"Robert","first_name":"Stéphanie"},{"first_name":"Wendy","last_name":"Peer","full_name":"Peer, Wendy"},{"full_name":"Swarup, Ranjan","last_name":"Swarup","first_name":"Ranjan"},{"full_name":"Ye, Songqing","last_name":"Ye","first_name":"Songqing"},{"first_name":"Lei","full_name":"Ge, Lei","last_name":"Ge"},{"last_name":"Cohen","full_name":"Cohen, Jerry","first_name":"Jerry"},{"first_name":"Angus","last_name":"Murphy","full_name":"Murphy, Angus"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí"},{"full_name":"Estelle, Mark","last_name":"Estelle","first_name":"Mark"}],"department":[{"_id":"JiFr"}],"language":[{"iso":"eng"}],"issue":"2","type":"journal_article","_id":"2835","date_published":"2013-06-01T00:00:00Z","doi":"10.1104/pp.113.217018","external_id":{"pmid":["23580592"]},"month":"06","publication_status":"published","quality_controlled":"1","oa":1,"publication":"Plant Physiology","intvolume":"       162"},{"quality_controlled":"1","publication_status":"published","publication":"Formal Aspects of Computing","intvolume":"        26","oa":1,"date_published":"2013-07-04T00:00:00Z","doi":"10.1007/s00165-013-0283-6","_id":"2836","month":"07","external_id":{"arxiv":["1004.2697"]},"arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","issue":"4","department":[{"_id":"KrCh"}],"ec_funded":1,"oa_version":"Preprint","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"},{"full_name":"Raman, Vishwanath","last_name":"Raman","first_name":"Vishwanath"}],"publist_id":"3963","scopus_import":1,"abstract":[{"text":"We study the automatic synthesis of fair non-repudiation protocols, a class of fair exchange protocols, used for digital contract signing. First, we show how to specify the objectives of the participating agents and the trusted third party as path formulas in linear temporal logic and prove that the satisfaction of these objectives imply fairness; a property required of fair exchange protocols. We then show that weak (co-operative) co-synthesis and classical (strictly competitive) co-synthesis fail, whereas assume-guarantee synthesis (AGS) succeeds. We demonstrate the success of AGS as follows: (a) any solution of AGS is attack-free; no subset of participants can violate the objectives of the other participants; (b) the Asokan-Shoup-Waidner certified mail protocol that has known vulnerabilities is not a solution of AGS; (c) the Kremer-Markowitch non-repudiation protocol is a solution of AGS; and (d) AGS presents a new and symmetric fair non-repudiation protocol that is attack-free. To our knowledge this is the first application of synthesis to fair non-repudiation protocols, and our results show how synthesis can both automatically discover vulnerabilities in protocols and generate correct protocols. The solution to AGS can be computed efficiently as the secure equilibrium solution of three-player graph games. ","lang":"eng"}],"day":"04","citation":{"ieee":"K. Chatterjee and V. Raman, “Assume-guarantee synthesis for digital contract signing,” <i>Formal Aspects of Computing</i>, vol. 26, no. 4. Springer, pp. 825–859, 2013.","mla":"Chatterjee, Krishnendu, and Vishwanath Raman. “Assume-Guarantee Synthesis for Digital Contract Signing.” <i>Formal Aspects of Computing</i>, vol. 26, no. 4, Springer, 2013, pp. 825–59, doi:<a href=\"https://doi.org/10.1007/s00165-013-0283-6\">10.1007/s00165-013-0283-6</a>.","apa":"Chatterjee, K., &#38; Raman, V. (2013). Assume-guarantee synthesis for digital contract signing. <i>Formal Aspects of Computing</i>. Springer. <a href=\"https://doi.org/10.1007/s00165-013-0283-6\">https://doi.org/10.1007/s00165-013-0283-6</a>","ista":"Chatterjee K, Raman V. 2013. Assume-guarantee synthesis for digital contract signing. Formal Aspects of Computing. 26(4), 825–859.","chicago":"Chatterjee, Krishnendu, and Vishwanath Raman. “Assume-Guarantee Synthesis for Digital Contract Signing.” <i>Formal Aspects of Computing</i>. Springer, 2013. <a href=\"https://doi.org/10.1007/s00165-013-0283-6\">https://doi.org/10.1007/s00165-013-0283-6</a>.","ama":"Chatterjee K, Raman V. Assume-guarantee synthesis for digital contract signing. <i>Formal Aspects of Computing</i>. 2013;26(4):825-859. doi:<a href=\"https://doi.org/10.1007/s00165-013-0283-6\">10.1007/s00165-013-0283-6</a>","short":"K. Chatterjee, V. Raman, Formal Aspects of Computing 26 (2013) 825–859."},"publisher":"Springer","date_updated":"2021-01-12T07:00:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Assume-guarantee synthesis for digital contract signing","page":"825 - 859","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1004.2697"}],"project":[{"_id":"2584A770-B435-11E9-9278-68D0E5697425","grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification","call_identifier":"FWF"},{"grant_number":"S11407","_id":"25863FF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Game Theory"},{"grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Quantitative Graph Games: Theory and Applications"},{"name":"Microsoft Research Faculty Fellowship","_id":"2587B514-B435-11E9-9278-68D0E5697425"}],"status":"public","volume":26,"date_created":"2018-12-11T11:59:51Z","year":"2013"},{"volume":18,"date_created":"2018-12-11T11:59:51Z","year":"2013","page":"1-58","status":"public","title":"The local semicircle law for a general class of random matrices","ddc":["530"],"pubrep_id":"406","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T07:00:06Z","publisher":"Institute of Mathematical Statistics","day":"29","citation":{"apa":"Erdös, L., Knowles, A., Yau, H., &#38; Yin, J. (2013). The local semicircle law for a general class of random matrices. <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/EJP.v18-2473\">https://doi.org/10.1214/EJP.v18-2473</a>","ama":"Erdös L, Knowles A, Yau H, Yin J. The local semicircle law for a general class of random matrices. <i>Electronic Journal of Probability</i>. 2013;18(59):1-58. doi:<a href=\"https://doi.org/10.1214/EJP.v18-2473\">10.1214/EJP.v18-2473</a>","chicago":"Erdös, László, Antti Knowles, Horng Yau, and Jun Yin. “The Local Semicircle Law for a General Class of Random Matrices.” <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics, 2013. <a href=\"https://doi.org/10.1214/EJP.v18-2473\">https://doi.org/10.1214/EJP.v18-2473</a>.","ista":"Erdös L, Knowles A, Yau H, Yin J. 2013. The local semicircle law for a general class of random matrices. Electronic Journal of Probability. 18(59), 1–58.","short":"L. Erdös, A. Knowles, H. Yau, J. Yin, Electronic Journal of Probability 18 (2013) 1–58.","ieee":"L. Erdös, A. Knowles, H. Yau, and J. Yin, “The local semicircle law for a general class of random matrices,” <i>Electronic Journal of Probability</i>, vol. 18, no. 59. Institute of Mathematical Statistics, pp. 1–58, 2013.","mla":"Erdös, László, et al. “The Local Semicircle Law for a General Class of Random Matrices.” <i>Electronic Journal of Probability</i>, vol. 18, no. 59, Institute of Mathematical Statistics, 2013, pp. 1–58, doi:<a href=\"https://doi.org/10.1214/EJP.v18-2473\">10.1214/EJP.v18-2473</a>."},"abstract":[{"lang":"eng","text":"We consider a general class of N × N random matrices whose entries hij are independent up to a symmetry constraint, but not necessarily identically distributed. Our main result is a local semicircle law which improves previous results [17] both in the bulk and at the edge. The error bounds are given in terms of the basic small parameter of the model, maxi,j E|hij|2. As a consequence, we prove the universality of the local n-point correlation functions in the bulk spectrum for a class of matrices whose entries do not have comparable variances, including random band matrices with band width W ≫N1-εn with some εn &gt; 0 and with a negligible mean-field component. In addition, we provide a coherent and pedagogical proof of the local semicircle law, streamlining and strengthening previous arguments from [17, 19, 6]."}],"has_accepted_license":"1","scopus_import":1,"author":[{"orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Antti","full_name":"Knowles, Antti","last_name":"Knowles"},{"first_name":"Horng","last_name":"Yau","full_name":"Yau, Horng"},{"full_name":"Yin, Jun","last_name":"Yin","first_name":"Jun"}],"oa_version":"Published Version","publist_id":"3962","file":[{"file_size":651497,"creator":"system","file_id":"5169","date_created":"2018-12-12T10:15:46Z","relation":"main_file","date_updated":"2020-07-14T12:45:50Z","file_name":"IST-2016-406-v1+1_2473-13759-1-PB.pdf","access_level":"open_access","content_type":"application/pdf","checksum":"aac9e52a00cb2f5149dc9e362b5ccf44"}],"department":[{"_id":"LaEr"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"file_date_updated":"2020-07-14T12:45:50Z","language":[{"iso":"eng"}],"type":"journal_article","issue":"59","doi":"10.1214/EJP.v18-2473","date_published":"2013-05-29T00:00:00Z","_id":"2837","month":"05","quality_controlled":"1","publication_status":"published","intvolume":"        18","publication":"Electronic Journal of Probability","oa":1},{"ddc":["570"],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Public Library of Science","date_updated":"2021-01-12T07:00:07Z","pubrep_id":"407","article_number":"e54285","title":"Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome","status":"public","volume":8,"year":"2013","date_created":"2018-12-11T11:59:52Z","has_accepted_license":"1","scopus_import":1,"abstract":[{"lang":"eng","text":"Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor development of infants and young children. DYRK1A, a candidate gene for DS abnormalities has been implicated in motor function due to its expression in motor nuclei in the adult brain, and its overexpression in DS mouse models leads to hyperactivity and altered motor learning. However, its precise role in the adult motor system, or its possible involvement in postnatal locomotor development has not yet been clarified. During the postnatal period we observed time-specific expression of Dyrk1A in discrete subsets of brainstem nuclei and spinal cord motor neurons. Interestingly, we describe for the first time the presence of Dyrk1A in the presynaptic terminal of the neuromuscular junctions and its axonal transport from the facial nucleus, suggesting a function for Dyrk1A in these structures. Relevant to DS, Dyrk1A overexpression in transgenic mice (TgDyrk1A) produces motor developmental alterations possibly contributing to DS motor phenotypes and modifies the numbers of motor cholinergic neurons, suggesting that the kinase may have a role in the development of the brainstem and spinal cord motor system."}],"day":"16","citation":{"ieee":"G. Arquè Fuste, A. Casanovas, and M. Dierssen, “Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome,” <i>PLoS One</i>, vol. 8, no. 1. Public Library of Science, 2013.","mla":"Arquè Fuste, Gloria, et al. “Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome.” <i>PLoS One</i>, vol. 8, no. 1, e54285, Public Library of Science, 2013, doi:<a href=\"https://doi.org/10.1371/journal.pone.0054285\">10.1371/journal.pone.0054285</a>.","ista":"Arquè Fuste G, Casanovas A, Dierssen M. 2013. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. PLoS One. 8(1), e54285.","ama":"Arquè Fuste G, Casanovas A, Dierssen M. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. <i>PLoS One</i>. 2013;8(1). doi:<a href=\"https://doi.org/10.1371/journal.pone.0054285\">10.1371/journal.pone.0054285</a>","chicago":"Arquè Fuste, Gloria, Anna Casanovas, and Mara Dierssen. “Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome.” <i>PLoS One</i>. Public Library of Science, 2013. <a href=\"https://doi.org/10.1371/journal.pone.0054285\">https://doi.org/10.1371/journal.pone.0054285</a>.","apa":"Arquè Fuste, G., Casanovas, A., &#38; Dierssen, M. (2013). Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0054285\">https://doi.org/10.1371/journal.pone.0054285</a>","short":"G. Arquè Fuste, A. Casanovas, M. Dierssen, PLoS One 8 (2013)."},"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"file":[{"content_type":"application/pdf","checksum":"512733b21419574a45f10cabef3d7f81","access_level":"open_access","file_name":"IST-2016-407-v1+1_journal.pone.0054285.pdf","date_updated":"2020-07-14T12:45:50Z","file_size":4795977,"creator":"system","date_created":"2018-12-12T10:15:38Z","file_id":"5160","relation":"main_file"}],"department":[{"_id":"SiHi"}],"publist_id":"3960","author":[{"last_name":"Arquè Fuste","full_name":"Arquè Fuste, Gloria","id":"3CF33908-F248-11E8-B48F-1D18A9856A87","first_name":"Gloria"},{"last_name":"Casanovas","full_name":"Casanovas, Anna","first_name":"Anna"},{"last_name":"Dierssen","full_name":"Dierssen, Mara","first_name":"Mara"}],"oa_version":"Published Version","publication_status":"published","quality_controlled":"1","intvolume":"         8","publication":"PLoS One","oa":1,"_id":"2838","date_published":"2013-01-16T00:00:00Z","doi":"10.1371/journal.pone.0054285","month":"01","language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:45:50Z","issue":"1","type":"journal_article"},{"scopus_import":"1","citation":{"mla":"Weber, Michele, et al. “Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients.” <i>Science</i>, vol. 339, no. 6117, American Association for the Advancement of Science, 2013, pp. 328–32, doi:<a href=\"https://doi.org/10.1126/science.1228456\">10.1126/science.1228456</a>.","ieee":"M. Weber <i>et al.</i>, “Interstitial dendritic cell guidance by haptotactic chemokine gradients,” <i>Science</i>, vol. 339, no. 6117. American Association for the Advancement of Science, pp. 328–332, 2013.","short":"M. Weber, R. Hauschild, J. Schwarz, C. Moussion, I. de Vries, D. Legler, S. Luther, M.T. Bollenbach, M.K. Sixt, Science 339 (2013) 328–332.","ama":"Weber M, Hauschild R, Schwarz J, et al. Interstitial dendritic cell guidance by haptotactic chemokine gradients. <i>Science</i>. 2013;339(6117):328-332. doi:<a href=\"https://doi.org/10.1126/science.1228456\">10.1126/science.1228456</a>","apa":"Weber, M., Hauschild, R., Schwarz, J., Moussion, C., de Vries, I., Legler, D., … Sixt, M. K. (2013). Interstitial dendritic cell guidance by haptotactic chemokine gradients. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1228456\">https://doi.org/10.1126/science.1228456</a>","chicago":"Weber, Michele, Robert Hauschild, Jan Schwarz, Christine Moussion, Ingrid de Vries, Daniel Legler, Sanjiv Luther, Mark Tobias Bollenbach, and Michael K Sixt. “Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients.” <i>Science</i>. American Association for the Advancement of Science, 2013. <a href=\"https://doi.org/10.1126/science.1228456\">https://doi.org/10.1126/science.1228456</a>.","ista":"Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler D, Luther S, Bollenbach MT, Sixt MK. 2013. Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science. 339(6117), 328–332."},"day":"18","abstract":[{"text":"Directional guidance of cells via gradients of chemokines is considered crucial for embryonic development, cancer dissemination, and immune responses. Nevertheless, the concept still lacks direct experimental confirmation in vivo. Here, we identify endogenous gradients of the chemokine CCL21 within mouse skin and show that they guide dendritic cells toward lymphatic vessels. Quantitative imaging reveals depots of CCL21 within lymphatic endothelial cells and steeply decaying gradients within the perilymphatic interstitium. These gradients match the migratory patterns of the dendritic cells, which directionally approach vessels from a distance of up to 90-micrometers. Interstitial CCL21 is immobilized to heparan sulfates, and its experimental delocalization or swamping the endogenous gradients abolishes directed migration. These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.","lang":"eng"}],"article_processing_charge":"No","title":"Interstitial dendritic cell guidance by haptotactic chemokine gradients","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2022-06-10T10:21:40Z","publisher":"American Association for the Advancement of Science","year":"2013","date_created":"2018-12-11T11:59:52Z","acknowledgement":"We thank M. Frank for technical assistance and S. Cremer, P. Schmalhorst, and E. Kiermaier for critical reading of the manuscript. This work was supported by a Humboldt Foundation postdoctoral fellowship (to M.W.), the German Research Foundation (Si1323 1,2 to M.S.), the Human Frontier Science Program (HFSP RGP0058/2011 to M.S.), the European Research Council (ERC StG 281556 to M.S.), and the Swiss National Science Foundation (31003A 127474 to D.F.L., 130488 to S.A.L.).","volume":339,"project":[{"name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","call_identifier":"FP7","_id":"25A603A2-B435-11E9-9278-68D0E5697425","grant_number":"281556"},{"_id":"25ABD200-B435-11E9-9278-68D0E5697425","grant_number":"RGP0058/2011","name":"Cell migration in complex environments: from in vivo experiments to theoretical models"}],"status":"public","main_file_link":[{"url":"https://kops.uni-konstanz.de/bitstream/123456789/26341/2/Weber_263418.pdf","open_access":"1"}],"article_type":"original","page":"328 - 332","month":"01","_id":"2839","doi":"10.1126/science.1228456","date_published":"2013-01-18T00:00:00Z","publication":"Science","oa":1,"intvolume":"       339","publication_status":"published","quality_controlled":"1","issue":"6117","type":"journal_article","language":[{"iso":"eng"}],"ec_funded":1,"department":[{"_id":"MiSi"},{"_id":"Bio"}],"publist_id":"3959","author":[{"last_name":"Weber","full_name":"Weber, Michele","id":"3A3FC708-F248-11E8-B48F-1D18A9856A87","first_name":"Michele"},{"orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert","last_name":"Hauschild","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schwarz","full_name":"Schwarz, Jan","id":"346C1EC6-F248-11E8-B48F-1D18A9856A87","first_name":"Jan"},{"full_name":"Moussion, Christine","last_name":"Moussion","first_name":"Christine","id":"3356F664-F248-11E8-B48F-1D18A9856A87"},{"last_name":"De Vries","full_name":"De Vries, Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","first_name":"Ingrid"},{"first_name":"Daniel","last_name":"Legler","full_name":"Legler, Daniel"},{"full_name":"Luther, Sanjiv","last_name":"Luther","first_name":"Sanjiv"},{"full_name":"Bollenbach, Mark Tobias","orcid":"0000-0003-4398-476X","last_name":"Bollenbach","first_name":"Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sixt","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K"}],"oa_version":"Published Version"},{"citation":{"chicago":"Van Cauter, Tiffany, Jeremy Camon, Alice Alvernhe, Coralie Elduayen, Francesca Sargolini, and Étienne Save. “Distinct Roles of Medial and Lateral Entorhinal Cortex in Spatial Cognition.” <i>Cerebral Cortex</i>. Oxford University Press, 2013. <a href=\"https://doi.org/10.1093/cercor/bhs033\">https://doi.org/10.1093/cercor/bhs033</a>.","ama":"Van Cauter T, Camon J, Alvernhe A, Elduayen C, Sargolini F, Save É. Distinct roles of medial and lateral entorhinal cortex in spatial cognition. <i>Cerebral Cortex</i>. 2013;23(2):451-459. doi:<a href=\"https://doi.org/10.1093/cercor/bhs033\">10.1093/cercor/bhs033</a>","ista":"Van Cauter T, Camon J, Alvernhe A, Elduayen C, Sargolini F, Save É. 2013. Distinct roles of medial and lateral entorhinal cortex in spatial cognition. Cerebral Cortex. 23(2), 451–459.","apa":"Van Cauter, T., Camon, J., Alvernhe, A., Elduayen, C., Sargolini, F., &#38; Save, É. (2013). Distinct roles of medial and lateral entorhinal cortex in spatial cognition. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/bhs033\">https://doi.org/10.1093/cercor/bhs033</a>","short":"T. Van Cauter, J. Camon, A. Alvernhe, C. Elduayen, F. Sargolini, É. Save, Cerebral Cortex 23 (2013) 451–459.","ieee":"T. Van Cauter, J. Camon, A. Alvernhe, C. Elduayen, F. Sargolini, and É. Save, “Distinct roles of medial and lateral entorhinal cortex in spatial cognition,” <i>Cerebral Cortex</i>, vol. 23, no. 2. Oxford University Press, pp. 451–459, 2013.","mla":"Van Cauter, Tiffany, et al. “Distinct Roles of Medial and Lateral Entorhinal Cortex in Spatial Cognition.” <i>Cerebral Cortex</i>, vol. 23, no. 2, Oxford University Press, 2013, pp. 451–59, doi:<a href=\"https://doi.org/10.1093/cercor/bhs033\">10.1093/cercor/bhs033</a>."},"day":"01","type":"journal_article","issue":"2","abstract":[{"lang":"eng","text":"It is known that the entorhinal cortex plays a crucial role in spatial cognition in rodents. Neuroanatomical and electrophysiological data suggest that there is a functional distinction between 2 subregions within the entorhinal cortex, the medial entorhinal cortex (MEC), and the lateral entorhinal cortex (LEC). Rats with MEC or LEC lesions were trained in 2 navigation tasks requiring allothetic (water maze task) or idiothetic (path integration) information processing and 2-object exploration tasks allowing testing of spatial and nonspatial processing of intramaze objects. MEC lesions mildly affected place navigation in the water maze and produced a path integration deficit. They also altered the processing of spatial information in both exploration tasks while sparing the processing of nonspatial information. LEC lesions did not affect navigation abilities in both the water maze and the path integration tasks. They altered spatial and nonspatial processing in the object exploration task but not in the one-trial recognition task. Overall, these results indicate that the MEC is important for spatial processing and path integration. The LEC has some influence on both spatial and nonspatial processes, suggesting that the 2 kinds of information interact at the level of the EC."}],"language":[{"iso":"eng"}],"month":"02","scopus_import":1,"doi":"10.1093/cercor/bhs033","date_published":"2013-02-01T00:00:00Z","_id":"2840","intvolume":"        23","publication":"Cerebral Cortex","quality_controlled":"1","publication_status":"published","date_created":"2018-12-11T11:59:52Z","year":"2013","volume":23,"author":[{"first_name":"Tiffany","last_name":"Van Cauter","full_name":"Van Cauter, Tiffany"},{"last_name":"Camon","full_name":"Camon, Jeremy","first_name":"Jeremy"},{"full_name":"Alvernhe, Alice","last_name":"Alvernhe","first_name":"Alice","id":"467FB3D4-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Coralie","last_name":"Elduayen","full_name":"Elduayen, Coralie"},{"last_name":"Sargolini","full_name":"Sargolini, Francesca","first_name":"Francesca"},{"first_name":"Étienne","full_name":"Save, Étienne","last_name":"Save"}],"oa_version":"None","status":"public","publist_id":"3958","page":"451 - 459","department":[{"_id":"JoCs"}],"title":"Distinct roles of medial and lateral entorhinal cortex in spatial cognition","publisher":"Oxford University Press","date_updated":"2021-01-12T07:00:08Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"citation":{"ama":"Morita H, Heisenberg C-PJ. Holding on and letting go: Cadherin turnover in cell intercalation. <i>Developmental Cell</i>. 2013;24(6):567-569. doi:<a href=\"https://doi.org/10.1016/j.devcel.2013.03.007\">10.1016/j.devcel.2013.03.007</a>","ista":"Morita H, Heisenberg C-PJ. 2013. Holding on and letting go: Cadherin turnover in cell intercalation. Developmental Cell. 24(6), 567–569.","apa":"Morita, H., &#38; Heisenberg, C.-P. J. (2013). Holding on and letting go: Cadherin turnover in cell intercalation. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2013.03.007\">https://doi.org/10.1016/j.devcel.2013.03.007</a>","chicago":"Morita, Hitoshi, and Carl-Philipp J Heisenberg. “Holding on and Letting Go: Cadherin Turnover in Cell Intercalation.” <i>Developmental Cell</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.devcel.2013.03.007\">https://doi.org/10.1016/j.devcel.2013.03.007</a>.","short":"H. Morita, C.-P.J. Heisenberg, Developmental Cell 24 (2013) 567–569.","ieee":"H. Morita and C.-P. J. Heisenberg, “Holding on and letting go: Cadherin turnover in cell intercalation,” <i>Developmental Cell</i>, vol. 24, no. 6. Cell Press, pp. 567–569, 2013.","mla":"Morita, Hitoshi, and Carl-Philipp J. Heisenberg. “Holding on and Letting Go: Cadherin Turnover in Cell Intercalation.” <i>Developmental Cell</i>, vol. 24, no. 6, Cell Press, 2013, pp. 567–69, doi:<a href=\"https://doi.org/10.1016/j.devcel.2013.03.007\">10.1016/j.devcel.2013.03.007</a>."},"day":"25","type":"journal_article","abstract":[{"text":"In zebrafish early development, blastoderm cells undergo extensive radial intercalations, triggering the spreading of the blastoderm over the yolk cell and thereby initiating embryonic body axis formation. Now reporting in Developmental Cell, Song et al. (2013) demonstrate a critical function for EGF-dependent E-cadherin endocytosis in promoting blastoderm cell intercalations.","lang":"eng"}],"issue":"6","language":[{"iso":"eng"}],"month":"05","scopus_import":1,"doi":"10.1016/j.devcel.2013.03.007","date_published":"2013-05-25T00:00:00Z","_id":"2841","intvolume":"        24","publication":"Developmental Cell","quality_controlled":"1","publication_status":"published","date_created":"2018-12-11T11:59:52Z","year":"2013","volume":24,"author":[{"first_name":"Hitoshi","id":"4C6E54C6-F248-11E8-B48F-1D18A9856A87","full_name":"Morita, Hitoshi","last_name":"Morita"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"oa_version":"None","status":"public","publist_id":"3956","page":"567 - 569","department":[{"_id":"CaHe"}],"title":"Holding on and letting go: Cadherin turnover in cell intercalation","date_updated":"2021-01-12T07:00:09Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Cell Press"},{"file_date_updated":"2020-07-14T12:45:50Z","language":[{"iso":"eng"}],"type":"journal_article","issue":"1","doi":"10.1016/j.tpb.2013.03.001","date_published":"2013-08-01T00:00:00Z","_id":"2842","month":"08","quality_controlled":"1","publication_status":"published","publication":"Theoretical Population Biology","intvolume":"        87","oa":1,"author":[{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Etheridge, Alison","last_name":"Etheridge","first_name":"Alison"},{"full_name":"Kelleher, Jerome","last_name":"Kelleher","first_name":"Jerome"},{"last_name":"Véber","full_name":"Véber, Amandine","first_name":"Amandine"}],"oa_version":"Submitted Version","publist_id":"3953","file":[{"file_id":"5288","relation":"main_file","date_created":"2018-12-12T10:17:33Z","creator":"system","file_size":1554712,"file_name":"IST-2016-558-v1+1_inference_revised3101NB.pdf","date_updated":"2020-07-14T12:45:50Z","access_level":"open_access","content_type":"application/pdf","checksum":"9bf9d9a6fd03dd9df50906891f393bf8"},{"file_id":"5289","relation":"main_file","date_created":"2018-12-12T10:17:34Z","creator":"system","file_size":822964,"file_name":"IST-2016-558-v1+2_inference_revised3101NBApp.pdf","date_updated":"2020-07-14T12:45:50Z","checksum":"2bceddb76edacd0cd5fad73051e2a928","access_level":"open_access","content_type":"application/pdf"}],"department":[{"_id":"NiBa"}],"ec_funded":1,"day":"01","citation":{"ama":"Barton NH, Etheridge A, Kelleher J, Véber A. Inference in two dimensions: Allele frequencies versus lengths of shared sequence blocks. <i>Theoretical Population Biology</i>. 2013;87(1):105-119. doi:<a href=\"https://doi.org/10.1016/j.tpb.2013.03.001\">10.1016/j.tpb.2013.03.001</a>","chicago":"Barton, Nicholas H, Alison Etheridge, Jerome Kelleher, and Amandine Véber. “Inference in Two Dimensions: Allele Frequencies versus Lengths of Shared Sequence Blocks.” <i>Theoretical Population Biology</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.tpb.2013.03.001\">https://doi.org/10.1016/j.tpb.2013.03.001</a>.","apa":"Barton, N. H., Etheridge, A., Kelleher, J., &#38; Véber, A. (2013). Inference in two dimensions: Allele frequencies versus lengths of shared sequence blocks. <i>Theoretical Population Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tpb.2013.03.001\">https://doi.org/10.1016/j.tpb.2013.03.001</a>","ista":"Barton NH, Etheridge A, Kelleher J, Véber A. 2013. Inference in two dimensions: Allele frequencies versus lengths of shared sequence blocks. Theoretical Population Biology. 87(1), 105–119.","short":"N.H. Barton, A. Etheridge, J. Kelleher, A. Véber, Theoretical Population Biology 87 (2013) 105–119.","ieee":"N. H. Barton, A. Etheridge, J. Kelleher, and A. Véber, “Inference in two dimensions: Allele frequencies versus lengths of shared sequence blocks,” <i>Theoretical Population Biology</i>, vol. 87, no. 1. Elsevier, pp. 105–119, 2013.","mla":"Barton, Nicholas H., et al. “Inference in Two Dimensions: Allele Frequencies versus Lengths of Shared Sequence Blocks.” <i>Theoretical Population Biology</i>, vol. 87, no. 1, Elsevier, 2013, pp. 105–19, doi:<a href=\"https://doi.org/10.1016/j.tpb.2013.03.001\">10.1016/j.tpb.2013.03.001</a>."},"abstract":[{"text":"We outline two approaches to inference of neighbourhood size, N, and dispersal rate, σ2, based on either allele frequencies or on the lengths of sequence blocks that are shared between genomes. Over intermediate timescales (10-100 generations, say), populations that live in two dimensions approach a quasi-equilibrium that is independent of both their local structure and their deeper history. Over such scales, the standardised covariance of allele frequencies (i.e. pairwise FS T) falls with the logarithm of distance, and depends only on neighbourhood size, N, and a 'local scale', κ; the rate of gene flow, σ2, cannot be inferred. We show how spatial correlations can be accounted for, assuming a Gaussian distribution of allele frequencies, giving maximum likelihood estimates of N and κ. Alternatively, inferences can be based on the distribution of the lengths of sequence that are identical between blocks of genomes: long blocks (&gt;0.1 cM, say) tell us about intermediate timescales, over which we assume a quasi-equilibrium. For large neighbourhood size, the distribution of long blocks is given directly by the classical Wright-Malécot formula; this relationship can be used to infer both N and σ2. With small neighbourhood size, there is an appreciable chance that recombinant lineages will coalesce back before escaping into the distant past. For this case, we show that if genomes are sampled from some distance apart, then the distribution of lengths of blocks that are identical in state is geometric, with a mean that depends on N and σ2.","lang":"eng"}],"has_accepted_license":"1","scopus_import":1,"volume":87,"date_created":"2018-12-11T11:59:53Z","year":"2013","page":"105 - 119","project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7"}],"status":"public","title":"Inference in two dimensions: Allele frequencies versus lengths of shared sequence blocks","ddc":["570"],"pubrep_id":"558","date_updated":"2021-01-12T07:00:09Z","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"language":[{"iso":"eng"}],"type":"conference","abstract":[{"text":"Mathematical objects can be measured unambiguously, but not so objects from our physical world. Even the total length of tubelike shapes has its difficulties. We introduce a combination of geometric, probabilistic, and topological methods to design a stable length estimate for tube-like shapes; that is: one that is insensitive to small shape changes.","lang":"eng"}],"day":"21","alternative_title":["LNCS"],"citation":{"mla":"Edelsbrunner, Herbert, and Florian Pausinger. “Stable Length Estimates of Tube-like Shapes.” <i>17th IAPR International Conference on Discrete Geometry for Computer Imagery</i>, vol. 7749, Springer, 2013, pp. XV–XIX, doi:<a href=\"https://doi.org/10.1007/978-3-642-37067-0\">10.1007/978-3-642-37067-0</a>.","ieee":"H. Edelsbrunner and F. Pausinger, “Stable length estimates of tube-like shapes,” in <i>17th IAPR International Conference on Discrete Geometry for Computer Imagery</i>, Seville, Spain, 2013, vol. 7749, pp. XV–XIX.","short":"H. Edelsbrunner, F. Pausinger, in:, 17th IAPR International Conference on Discrete Geometry for Computer Imagery, Springer, 2013, pp. XV–XIX.","chicago":"Edelsbrunner, Herbert, and Florian Pausinger. “Stable Length Estimates of Tube-like Shapes.” In <i>17th IAPR International Conference on Discrete Geometry for Computer Imagery</i>, 7749:XV–XIX. Springer, 2013. <a href=\"https://doi.org/10.1007/978-3-642-37067-0\">https://doi.org/10.1007/978-3-642-37067-0</a>.","ista":"Edelsbrunner H, Pausinger F. 2013. Stable length estimates of tube-like shapes. 17th IAPR International Conference on Discrete Geometry for Computer Imagery. DGCI: Discrete Geometry for Computer Imagery, LNCS, vol. 7749, XV–XIX.","apa":"Edelsbrunner, H., &#38; Pausinger, F. (2013). Stable length estimates of tube-like shapes. In <i>17th IAPR International Conference on Discrete Geometry for Computer Imagery</i> (Vol. 7749, pp. XV–XIX). Seville, Spain: Springer. <a href=\"https://doi.org/10.1007/978-3-642-37067-0\">https://doi.org/10.1007/978-3-642-37067-0</a>","ama":"Edelsbrunner H, Pausinger F. Stable length estimates of tube-like shapes. In: <i>17th IAPR International Conference on Discrete Geometry for Computer Imagery</i>. Vol 7749. Springer; 2013:XV-XIX. doi:<a href=\"https://doi.org/10.1007/978-3-642-37067-0\">10.1007/978-3-642-37067-0</a>"},"quality_controlled":"1","publication_status":"published","intvolume":"      7749","publication":"17th IAPR International Conference on Discrete Geometry for Computer Imagery","doi":"10.1007/978-3-642-37067-0","related_material":{"record":[{"relation":"later_version","id":"2255","status":"public"}]},"date_published":"2013-02-21T00:00:00Z","_id":"2843","month":"02","scopus_import":1,"conference":{"location":"Seville, Spain","end_date":"2013-03-22","start_date":"2013-03-20","name":"DGCI: Discrete Geometry for Computer Imagery"},"page":"XV - XIX","oa_version":"None","author":[{"last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert"},{"id":"2A77D7A2-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","last_name":"Pausinger","orcid":"0000-0002-8379-3768","full_name":"Pausinger, Florian"}],"publist_id":"3952","status":"public","volume":7749,"date_created":"2018-12-11T11:59:53Z","year":"2013","date_updated":"2023-02-23T10:35:00Z","publisher":"Springer","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Stable length estimates of tube-like shapes","department":[{"_id":"HeEd"}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T07:00:10Z","publisher":"Cell Press","ec_funded":1,"title":"An auxin transport mechanism restricts positive orthogravitropism in lateral roots","department":[{"_id":"JiFr"},{"_id":"EvBe"}],"status":"public","publist_id":"3950","project":[{"name":"Hormonal cross-talk in plant organogenesis","call_identifier":"FP7","_id":"253FCA6A-B435-11E9-9278-68D0E5697425","grant_number":"207362"}],"oa_version":"None","author":[{"full_name":"Rosquete, Michel","last_name":"Rosquete","first_name":"Michel"},{"id":"49E91952-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel","last_name":"Von Wangenheim","full_name":"Von Wangenheim, Daniel","orcid":"0000-0002-6862-1247"},{"id":"3F45B078-F248-11E8-B48F-1D18A9856A87","first_name":"Peter","last_name":"Marhavy","orcid":"0000-0001-5227-5741","full_name":"Marhavy, Peter"},{"full_name":"Barbez, Elke","last_name":"Barbez","first_name":"Elke"},{"first_name":"Ernst","last_name":"Stelzer","full_name":"Stelzer, Ernst"},{"last_name":"Benková","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva"},{"first_name":"Alexis","full_name":"Maizel, Alexis","last_name":"Maizel"},{"first_name":"Jürgen","last_name":"Kleine Vehn","full_name":"Kleine Vehn, Jürgen"}],"page":"817 - 822","year":"2013","date_created":"2018-12-11T11:59:53Z","volume":23,"intvolume":"        23","publication":"Current Biology","publication_status":"published","quality_controlled":"1","scopus_import":1,"month":"05","_id":"2844","date_published":"2013-05-06T00:00:00Z","doi":"10.1016/j.cub.2013.03.064","issue":"9","abstract":[{"text":"As soon as a seed germinates, plant growth relates to gravity to ensure that the root penetrates the soil and the shoot expands aerially. Whereas mechanisms of positive and negative orthogravitropism of primary roots and shoots are relatively well understood [1-3], lateral organs often show more complex growth behavior [4]. Lateral roots (LRs) seemingly suppress positive gravitropic growth and show a defined gravitropic set-point angle (GSA) that allows radial expansion of the root system (plagiotropism) [3, 4]. Despite its eminent importance for root architecture, it so far remains completely unknown how lateral organs partially suppress positive orthogravitropism. Here we show that the phytohormone auxin steers GSA formation and limits positive orthogravitropism in LR. Low and high auxin levels/signaling lead to radial or axial root systems, respectively. At a cellular level, it is the auxin transport-dependent regulation of asymmetric growth in the elongation zone that determines GSA. Our data suggest that strong repression of PIN4/PIN7 and transient PIN3 expression limit auxin redistribution in young LR columella cells. We conclude that PIN activity, by temporally limiting the asymmetric auxin fluxes in the tip of LRs, induces transient, differential growth responses in the elongation zone and, consequently, controls root architecture.","lang":"eng"}],"type":"journal_article","language":[{"iso":"eng"}],"citation":{"ieee":"M. Rosquete <i>et al.</i>, “An auxin transport mechanism restricts positive orthogravitropism in lateral roots,” <i>Current Biology</i>, vol. 23, no. 9. Cell Press, pp. 817–822, 2013.","mla":"Rosquete, Michel, et al. “An Auxin Transport Mechanism Restricts Positive Orthogravitropism in Lateral Roots.” <i>Current Biology</i>, vol. 23, no. 9, Cell Press, 2013, pp. 817–22, doi:<a href=\"https://doi.org/10.1016/j.cub.2013.03.064\">10.1016/j.cub.2013.03.064</a>.","chicago":"Rosquete, Michel, Daniel von Wangenheim, Peter Marhavý, Elke Barbez, Ernst Stelzer, Eva Benková, Alexis Maizel, and Jürgen Kleine Vehn. “An Auxin Transport Mechanism Restricts Positive Orthogravitropism in Lateral Roots.” <i>Current Biology</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.cub.2013.03.064\">https://doi.org/10.1016/j.cub.2013.03.064</a>.","apa":"Rosquete, M., von Wangenheim, D., Marhavý, P., Barbez, E., Stelzer, E., Benková, E., … Kleine Vehn, J. (2013). An auxin transport mechanism restricts positive orthogravitropism in lateral roots. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2013.03.064\">https://doi.org/10.1016/j.cub.2013.03.064</a>","ista":"Rosquete M, von Wangenheim D, Marhavý P, Barbez E, Stelzer E, Benková E, Maizel A, Kleine Vehn J. 2013. An auxin transport mechanism restricts positive orthogravitropism in lateral roots. Current Biology. 23(9), 817–822.","ama":"Rosquete M, von Wangenheim D, Marhavý P, et al. An auxin transport mechanism restricts positive orthogravitropism in lateral roots. <i>Current Biology</i>. 2013;23(9):817-822. doi:<a href=\"https://doi.org/10.1016/j.cub.2013.03.064\">10.1016/j.cub.2013.03.064</a>","short":"M. Rosquete, D. von Wangenheim, P. Marhavý, E. Barbez, E. Stelzer, E. Benková, A. Maizel, J. Kleine Vehn, Current Biology 23 (2013) 817–822."},"day":"06"},{"status":"public","publist_id":"3949","oa_version":"None","author":[{"first_name":"Tobias","last_name":"Rose","full_name":"Rose, Tobias"},{"id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","last_name":"Schönenberger","full_name":"Schönenberger, Philipp"},{"first_name":"Karel","full_name":"Jezek, Karel","last_name":"Jezek"},{"first_name":"Thomas","full_name":"Oertner, Thomas","last_name":"Oertner"}],"page":"1109 - 1121","year":"2013","date_created":"2018-12-11T11:59:54Z","volume":77,"date_updated":"2021-01-12T07:00:11Z","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Developmental refinement of vesicle cycling at Schaffer collateral synapses","department":[{"_id":"JoCs"}],"abstract":[{"text":"At synapses formed between dissociated neurons, about half of all synaptic vesicles are refractory to evoked release, forming the so-called &quot;resting pool.&quot; Here, we use optical measurements of vesicular pH to study developmental changes in pool partitioning and vesicle cycling in cultured hippocampal slices. Two-photon imaging of a genetically encoded two-color release sensor (ratio-sypHy) allowed us to perform calibrated measurements at individual Schaffer collateral boutons. Mature boutons released a large fraction of their vesicles during simulated place field activity, and vesicle retrieval rates were 7-fold higher compared to immature boutons. Saturating stimulation mobilized essentially all vesicles at mature synapses. Resting pool formation and a concomitant reduction in evoked release was induced by chronic depolarization but not by acute inhibition of the protein phosphatase calcineurin. We conclude that synapses in CA1 undergo a prominent refinement of vesicle use during early postnatal development that is not recapitulated in dissociated neuronal culture.","lang":"eng"}],"issue":"6","type":"journal_article","language":[{"iso":"eng"}],"citation":{"short":"T. Rose, P. Schönenberger, K. Jezek, T. Oertner, Neuron 77 (2013) 1109–1121.","apa":"Rose, T., Schönenberger, P., Jezek, K., &#38; Oertner, T. (2013). Developmental refinement of vesicle cycling at Schaffer collateral synapses. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">https://doi.org/10.1016/j.neuron.2013.01.021</a>","ista":"Rose T, Schönenberger P, Jezek K, Oertner T. 2013. Developmental refinement of vesicle cycling at Schaffer collateral synapses. Neuron. 77(6), 1109–1121.","ama":"Rose T, Schönenberger P, Jezek K, Oertner T. Developmental refinement of vesicle cycling at Schaffer collateral synapses. <i>Neuron</i>. 2013;77(6):1109-1121. doi:<a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">10.1016/j.neuron.2013.01.021</a>","chicago":"Rose, Tobias, Philipp Schönenberger, Karel Jezek, and Thomas Oertner. “Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses.” <i>Neuron</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">https://doi.org/10.1016/j.neuron.2013.01.021</a>.","mla":"Rose, Tobias, et al. “Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses.” <i>Neuron</i>, vol. 77, no. 6, Elsevier, 2013, pp. 1109–21, doi:<a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">10.1016/j.neuron.2013.01.021</a>.","ieee":"T. Rose, P. Schönenberger, K. Jezek, and T. Oertner, “Developmental refinement of vesicle cycling at Schaffer collateral synapses,” <i>Neuron</i>, vol. 77, no. 6. Elsevier, pp. 1109–1121, 2013."},"day":"20","publication":"Neuron","intvolume":"        77","publication_status":"published","quality_controlled":"1","scopus_import":1,"month":"03","_id":"2845","doi":"10.1016/j.neuron.2013.01.021","date_published":"2013-03-20T00:00:00Z"},{"date_updated":"2023-09-07T11:36:36Z","publisher":"Springer","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Structural Counter Abstraction","main_file_link":[{"url":"http://arise.or.at/pubpdf/Structural_Counter_Abstraction.pdf","open_access":"1"}],"project":[{"name":"Quantitative Reactive Modeling","call_identifier":"FP7","_id":"25EE3708-B435-11E9-9278-68D0E5697425","grant_number":"267989"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","grant_number":"S 11407_N23","name":"Rigorous Systems Engineering","call_identifier":"FWF"}],"status":"public","page":"62 - 77","date_created":"2018-12-11T11:59:54Z","year":"2013","volume":7795,"scopus_import":1,"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"1405"}]},"abstract":[{"text":"Depth-Bounded Systems form an expressive class of well-structured transition systems. They can model a wide range of concurrent infinite-state systems including those with dynamic thread creation, dynamically changing communication topology, and complex shared heap structures. We present the first method to automatically prove fair termination of depth-bounded systems. Our method uses a numerical abstraction of the system, which we obtain by systematically augmenting an over-approximation of the system’s reachable states with a finite set of counters. This numerical abstraction can be analyzed with existing termination provers. What makes our approach unique is the way in which it exploits the well-structuredness of the analyzed system. We have implemented our work in a prototype tool and used it to automatically prove liveness properties of complex concurrent systems, including nonblocking algorithms such as Treiber’s stack and several distributed processes. Many of these examples are beyond the scope of termination analyses that are based on traditional counter abstractions.","lang":"eng"}],"citation":{"ieee":"K. Bansal, E. Koskinen, T. Wies, and D. Zufferey, “Structural Counter Abstraction,” vol. 7795. Springer, pp. 62–77, 2013.","mla":"Bansal, Kshitij, et al. <i>Structural Counter Abstraction</i>. Edited by Nir Piterman and Scott Smolka, vol. 7795, Springer, 2013, pp. 62–77, doi:<a href=\"https://doi.org/10.1007/978-3-642-36742-7_5\">10.1007/978-3-642-36742-7_5</a>.","apa":"Bansal, K., Koskinen, E., Wies, T., &#38; Zufferey, D. (2013). Structural Counter Abstraction. (N. Piterman &#38; S. Smolka, Eds.). Presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Rome, Italy: Springer. <a href=\"https://doi.org/10.1007/978-3-642-36742-7_5\">https://doi.org/10.1007/978-3-642-36742-7_5</a>","ista":"Bansal K, Koskinen E, Wies T, Zufferey D. 2013. Structural Counter Abstraction (eds. N. Piterman &#38; S. Smolka). 7795, 62–77.","ama":"Bansal K, Koskinen E, Wies T, Zufferey D. Structural Counter Abstraction. Piterman N, Smolka S, eds. 2013;7795:62-77. doi:<a href=\"https://doi.org/10.1007/978-3-642-36742-7_5\">10.1007/978-3-642-36742-7_5</a>","chicago":"Bansal, Kshitij, Eric Koskinen, Thomas Wies, and Damien Zufferey. “Structural Counter Abstraction.” Edited by Nir Piterman and Scott Smolka. Lecture Notes in Computer Science. Springer, 2013. <a href=\"https://doi.org/10.1007/978-3-642-36742-7_5\">https://doi.org/10.1007/978-3-642-36742-7_5</a>.","short":"K. Bansal, E. Koskinen, T. Wies, D. Zufferey, 7795 (2013) 62–77."},"day":"01","department":[{"_id":"ToHe"}],"ec_funded":1,"author":[{"first_name":"Kshitij","last_name":"Bansal","full_name":"Bansal, Kshitij"},{"last_name":"Koskinen","full_name":"Koskinen, Eric","first_name":"Eric"},{"full_name":"Wies, Thomas","last_name":"Wies","first_name":"Thomas","id":"447BFB88-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Zufferey","full_name":"Zufferey, Damien","orcid":"0000-0002-3197-8736","id":"4397AC76-F248-11E8-B48F-1D18A9856A87","first_name":"Damien"}],"oa_version":"Submitted Version","publist_id":"3947","series_title":"Lecture Notes in Computer Science","editor":[{"first_name":"Nir","full_name":"Piterman, Nir","last_name":"Piterman"},{"last_name":"Smolka","full_name":"Smolka, Scott","first_name":"Scott"}],"intvolume":"      7795","oa":1,"quality_controlled":"1","publication_status":"published","month":"03","conference":{"end_date":"2013-03-24","location":"Rome, Italy","name":"TACAS: Tools and Algorithms for the Construction and Analysis of Systems","start_date":"2013-03-16"},"doi":"10.1007/978-3-642-36742-7_5","date_published":"2013-03-01T00:00:00Z","_id":"2847","type":"conference","language":[{"iso":"eng"}],"alternative_title":["LNCS"]},{"article_processing_charge":"No","title":"The simplest maximum entropy model for collective behavior in a neural network","article_number":"P03011","publisher":"IOP Publishing Ltd.","date_updated":"2021-01-12T07:00:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2013","date_created":"2018-12-11T11:59:55Z","acknowledgement":"his work was supported in part by NSF Grants IIS-0613435 and PHY-0957573, by NIH Grants R01 EY14196 and P50 GM071508, by the Fannie and John Hertz Foundation, by the Human Frontiers Science Program, by the Swartz Foundation, and by the WM Keck Foundation.\r\n","volume":2013,"status":"public","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1207.6319"}],"article_type":"original","scopus_import":1,"citation":{"mla":"Tkačik, Gašper, et al. “The Simplest Maximum Entropy Model for Collective Behavior in a Neural Network.” <i>Journal of Statistical Mechanics Theory and Experiment</i>, vol. 2013, no. 3, P03011, IOP Publishing Ltd., 2013, doi:<a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03011\">10.1088/1742-5468/2013/03/P03011</a>.","ieee":"G. Tkačik, O. Marre, T. Mora, D. Amodei, M. Berry, and W. Bialek, “The simplest maximum entropy model for collective behavior in a neural network,” <i>Journal of Statistical Mechanics Theory and Experiment</i>, vol. 2013, no. 3. IOP Publishing Ltd., 2013.","short":"G. Tkačik, O. Marre, T. Mora, D. Amodei, M. Berry, W. Bialek, Journal of Statistical Mechanics Theory and Experiment 2013 (2013).","chicago":"Tkačik, Gašper, Olivier Marre, Thierry Mora, Dario Amodei, Michael Berry, and William Bialek. “The Simplest Maximum Entropy Model for Collective Behavior in a Neural Network.” <i>Journal of Statistical Mechanics Theory and Experiment</i>. IOP Publishing Ltd., 2013. <a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03011\">https://doi.org/10.1088/1742-5468/2013/03/P03011</a>.","ista":"Tkačik G, Marre O, Mora T, Amodei D, Berry M, Bialek W. 2013. The simplest maximum entropy model for collective behavior in a neural network. Journal of Statistical Mechanics Theory and Experiment. 2013(3), P03011.","apa":"Tkačik, G., Marre, O., Mora, T., Amodei, D., Berry, M., &#38; Bialek, W. (2013). The simplest maximum entropy model for collective behavior in a neural network. <i>Journal of Statistical Mechanics Theory and Experiment</i>. IOP Publishing Ltd. <a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03011\">https://doi.org/10.1088/1742-5468/2013/03/P03011</a>","ama":"Tkačik G, Marre O, Mora T, Amodei D, Berry M, Bialek W. The simplest maximum entropy model for collective behavior in a neural network. <i>Journal of Statistical Mechanics Theory and Experiment</i>. 2013;2013(3). doi:<a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03011\">10.1088/1742-5468/2013/03/P03011</a>"},"day":"12","abstract":[{"lang":"eng","text":"Recent work emphasizes that the maximum entropy principle provides a bridge between statistical mechanics models for collective behavior in neural networks and experiments on networks of real neurons. Most of this work has focused on capturing the measured correlations among pairs of neurons. Here we suggest an alternative, constructing models that are consistent with the distribution of global network activity, i.e. the probability that K out of N cells in the network generate action potentials in the same small time bin. The inverse problem that we need to solve in constructing the model is analytically tractable, and provides a natural 'thermodynamics' for the network in the limit of large N. We analyze the responses of neurons in a small patch of the retina to naturalistic stimuli, and find that the implied thermodynamics is very close to an unusual critical point, in which the entropy (in proper units) is exactly equal to the energy. © 2013 IOP Publishing Ltd and SISSA Medialab srl.\r\n"}],"department":[{"_id":"GaTk"}],"publist_id":"3942","author":[{"full_name":"Tkacik, Gasper","orcid":"0000-0002-6699-1455","last_name":"Tkacik","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Marre, Olivier","last_name":"Marre","first_name":"Olivier"},{"first_name":"Thierry","last_name":"Mora","full_name":"Mora, Thierry"},{"first_name":"Dario","last_name":"Amodei","full_name":"Amodei, Dario"},{"first_name":"Michael","last_name":"Berry","full_name":"Berry, Michael"},{"full_name":"Bialek, William","last_name":"Bialek","first_name":"William"}],"oa_version":"Preprint","external_id":{"arxiv":["1207.6319"]},"arxiv":1,"month":"03","_id":"2850","date_published":"2013-03-12T00:00:00Z","doi":"10.1088/1742-5468/2013/03/P03011","publication":"Journal of Statistical Mechanics Theory and Experiment","intvolume":"      2013","oa":1,"publication_status":"published","quality_controlled":"1","issue":"3","type":"journal_article","language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"issue":"3","abstract":[{"lang":"eng","text":"The number of possible activity patterns in a population of neurons grows exponentially with the size of the population. Typical experiments explore only a tiny fraction of the large space of possible activity patterns in the case of populations with more than 10 or 20 neurons. It is thus impossible, in this undersampled regime, to estimate the probabilities with which most of the activity patterns occur. As a result, the corresponding entropy - which is a measure of the computational power of the neural population - cannot be estimated directly. We propose a simple scheme for estimating the entropy in the undersampled regime, which bounds its value from both below and above. The lower bound is the usual 'naive' entropy of the experimental frequencies. The upper bound results from a hybrid approximation of the entropy which makes use of the naive estimate, a maximum entropy fit, and a coverage adjustment. We apply our simple scheme to artificial data, in order to check their accuracy; we also compare its performance to those of several previously defined entropy estimators. We then apply it to actual measurements of neural activity in populations with up to 100 cells. Finally, we discuss the similarities and differences between the proposed simple estimation scheme and various earlier methods. © 2013 IOP Publishing Ltd and SISSA Medialab srl."}],"type":"journal_article","day":"12","citation":{"mla":"Berry, Michael, et al. “A Simple Method for Estimating the Entropy of Neural Activity.” <i>Journal of Statistical Mechanics Theory and Experiment</i>, vol. 2013, no. 3, P03015, IOP Publishing Ltd., 2013, doi:<a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03015\">10.1088/1742-5468/2013/03/P03015</a>.","ieee":"M. Berry, G. Tkačik, J. Dubuis, O. Marre, and R. Da Silveira, “A simple method for estimating the entropy of neural activity,” <i>Journal of Statistical Mechanics Theory and Experiment</i>, vol. 2013, no. 3. IOP Publishing Ltd., 2013.","short":"M. Berry, G. Tkačik, J. Dubuis, O. Marre, R. Da Silveira, Journal of Statistical Mechanics Theory and Experiment 2013 (2013).","ama":"Berry M, Tkačik G, Dubuis J, Marre O, Da Silveira R. A simple method for estimating the entropy of neural activity. <i>Journal of Statistical Mechanics Theory and Experiment</i>. 2013;2013(3). doi:<a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03015\">10.1088/1742-5468/2013/03/P03015</a>","apa":"Berry, M., Tkačik, G., Dubuis, J., Marre, O., &#38; Da Silveira, R. (2013). A simple method for estimating the entropy of neural activity. <i>Journal of Statistical Mechanics Theory and Experiment</i>. IOP Publishing Ltd. <a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03015\">https://doi.org/10.1088/1742-5468/2013/03/P03015</a>","ista":"Berry M, Tkačik G, Dubuis J, Marre O, Da Silveira R. 2013. A simple method for estimating the entropy of neural activity. Journal of Statistical Mechanics Theory and Experiment. 2013(3), P03015.","chicago":"Berry, Michael, Gašper Tkačik, Julien Dubuis, Olivier Marre, and Ravá Da Silveira. “A Simple Method for Estimating the Entropy of Neural Activity.” <i>Journal of Statistical Mechanics Theory and Experiment</i>. IOP Publishing Ltd., 2013. <a href=\"https://doi.org/10.1088/1742-5468/2013/03/P03015\">https://doi.org/10.1088/1742-5468/2013/03/P03015</a>."},"publication_status":"published","quality_controlled":"1","intvolume":"      2013","publication":"Journal of Statistical Mechanics Theory and Experiment","_id":"2851","date_published":"2013-03-12T00:00:00Z","doi":"10.1088/1742-5468/2013/03/P03015","scopus_import":1,"month":"03","status":"public","publist_id":"3941","oa_version":"None","author":[{"last_name":"Berry","full_name":"Berry, Michael","first_name":"Michael"},{"last_name":"Tkacik","orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gasper"},{"first_name":"Julien","last_name":"Dubuis","full_name":"Dubuis, Julien"},{"first_name":"Olivier","last_name":"Marre","full_name":"Marre, Olivier"},{"full_name":"Da Silveira, Ravá","last_name":"Da Silveira","first_name":"Ravá"}],"volume":2013,"year":"2013","date_created":"2018-12-11T11:59:56Z","date_updated":"2021-01-12T07:00:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"IOP Publishing Ltd.","article_number":"P03015","title":"A simple method for estimating the entropy of neural activity","department":[{"_id":"GaTk"}]},{"scopus_import":"1","related_material":{"record":[{"status":"public","id":"9751","relation":"research_data"}]},"abstract":[{"text":"High relatedness among interacting individuals has generally been considered a precondition for the evolution of altruism. However, kin-selection theory also predicts the evolution of altruism when relatedness is low, as long as the cost of the altruistic act is minor compared with its benefit. Here, we demonstrate evidence for a low-cost altruistic act in bacteria. We investigated Escherichia coli responding to the attack of an obligately lytic phage by committing suicide in order to prevent parasite transmission to nearby relatives. We found that bacterial suicide provides large benefits to survivors at marginal costs to committers. The cost of suicide was low, because infected cells are moribund, rapidly dying upon phage infection, such that no more opportunity for reproduction remains. As a consequence of its marginal cost, host suicide was selectively favoured even when relatedness between committers and survivors approached zero. Altogether, our findings demonstrate that low-cost suicide can evolve with ease, represents an effective host-defence strategy, and seems to be widespread among microbes. Moreover, low-cost suicide might also occur in higher organisms as exemplified by infected social insect workers leaving the colony to die in isolation.","lang":"eng"}],"citation":{"mla":"Refardt, Dominik, et al. “Altruism Can Evolve When Relatedness Is Low: Evidence from Bacteria Committing Suicide upon Phage Infection.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 280, no. 1759, The Royal Society, 2013, doi:<a href=\"https://doi.org/10.1098/rspb.2012.3035\">10.1098/rspb.2012.3035</a>.","ieee":"D. Refardt, T. Bergmiller, and R. Kümmerli, “Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 280, no. 1759. The Royal Society, 2013.","short":"D. Refardt, T. Bergmiller, R. Kümmerli, Proceedings of the Royal Society of London Series B Biological Sciences 280 (2013).","ista":"Refardt D, Bergmiller T, Kümmerli R. 2013. Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection. Proceedings of the Royal Society of London Series B Biological Sciences. 280(1759).","ama":"Refardt D, Bergmiller T, Kümmerli R. Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2013;280(1759). doi:<a href=\"https://doi.org/10.1098/rspb.2012.3035\">10.1098/rspb.2012.3035</a>","chicago":"Refardt, Dominik, Tobias Bergmiller, and Rolf Kümmerli. “Altruism Can Evolve When Relatedness Is Low: Evidence from Bacteria Committing Suicide upon Phage Infection.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. The Royal Society, 2013. <a href=\"https://doi.org/10.1098/rspb.2012.3035\">https://doi.org/10.1098/rspb.2012.3035</a>.","apa":"Refardt, D., Bergmiller, T., &#38; Kümmerli, R. (2013). Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rspb.2012.3035\">https://doi.org/10.1098/rspb.2012.3035</a>"},"day":"22","date_updated":"2023-10-18T06:43:23Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"The Royal Society","article_processing_charge":"No","title":"Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection","pmid":1,"status":"public","article_type":"original","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619501/","open_access":"1"}],"year":"2013","date_created":"2018-12-11T11:59:56Z","volume":280,"oa":1,"publication":"Proceedings of the Royal Society of London Series B Biological Sciences","intvolume":"       280","publication_status":"published","quality_controlled":"1","external_id":{"pmid":["23516238"]},"month":"05","_id":"2853","date_published":"2013-05-22T00:00:00Z","doi":"10.1098/rspb.2012.3035","issue":"1759","type":"journal_article","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1471-2954"]},"department":[{"_id":"CaGu"}],"publist_id":"3939","author":[{"last_name":"Refardt","full_name":"Refardt, Dominik","first_name":"Dominik"},{"id":"2C471CFA-F248-11E8-B48F-1D18A9856A87","first_name":"Tobias","last_name":"Bergmiller","orcid":"0000-0001-5396-4346","full_name":"Bergmiller, Tobias"},{"full_name":"Kümmerli, Rolf","last_name":"Kümmerli","first_name":"Rolf"}],"oa_version":"Submitted Version"},{"has_accepted_license":"1","scopus_import":1,"day":"01","citation":{"ieee":"K. Chatterjee, L. De Alfaro, and T. A. Henzinger, “Strategy improvement for concurrent reachability and turn based stochastic safety games,” <i>Journal of Computer and System Sciences</i>, vol. 79, no. 5. Elsevier, pp. 640–657, 2013.","mla":"Chatterjee, Krishnendu, et al. “Strategy Improvement for Concurrent Reachability and Turn Based Stochastic Safety Games.” <i>Journal of Computer and System Sciences</i>, vol. 79, no. 5, Elsevier, 2013, pp. 640–57, doi:<a href=\"https://doi.org/10.1016/j.jcss.2012.12.001\">10.1016/j.jcss.2012.12.001</a>.","ista":"Chatterjee K, De Alfaro L, Henzinger TA. 2013. Strategy improvement for concurrent reachability and turn based stochastic safety games. Journal of Computer and System Sciences. 79(5), 640–657.","chicago":"Chatterjee, Krishnendu, Luca De Alfaro, and Thomas A Henzinger. “Strategy Improvement for Concurrent Reachability and Turn Based Stochastic Safety Games.” <i>Journal of Computer and System Sciences</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.jcss.2012.12.001\">https://doi.org/10.1016/j.jcss.2012.12.001</a>.","apa":"Chatterjee, K., De Alfaro, L., &#38; Henzinger, T. A. (2013). Strategy improvement for concurrent reachability and turn based stochastic safety games. <i>Journal of Computer and System Sciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jcss.2012.12.001\">https://doi.org/10.1016/j.jcss.2012.12.001</a>","ama":"Chatterjee K, De Alfaro L, Henzinger TA. Strategy improvement for concurrent reachability and turn based stochastic safety games. <i>Journal of Computer and System Sciences</i>. 2013;79(5):640-657. doi:<a href=\"https://doi.org/10.1016/j.jcss.2012.12.001\">10.1016/j.jcss.2012.12.001</a>","short":"K. Chatterjee, L. De Alfaro, T.A. Henzinger, Journal of Computer and System Sciences 79 (2013) 640–657."},"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","abstract":[{"text":"We consider concurrent games played on graphs. At every round of a game, each player simultaneously and independently selects a move; the moves jointly determine the transition to a successor state. Two basic objectives are the safety objective to stay forever in a given set of states, and its dual, the reachability objective to reach a given set of states. First, we present a simple proof of the fact that in concurrent reachability games, for all ε&gt;0, memoryless ε-optimal strategies exist. A memoryless strategy is independent of the history of plays, and an ε-optimal strategy achieves the objective with probability within ε of the value of the game. In contrast to previous proofs of this fact, our proof is more elementary and more combinatorial. Second, we present a strategy-improvement (a.k.a. policy-iteration) algorithm for concurrent games with reachability objectives. Finally, we present a strategy-improvement algorithm for turn-based stochastic games (where each player selects moves in turns) with safety objectives. Our algorithms yield sequences of player-1 strategies which ensure probabilities of winning that converge monotonically (from below) to the value of the game. © 2012 Elsevier Inc.","lang":"eng"}],"article_processing_charge":"No","title":"Strategy improvement for concurrent reachability and turn based stochastic safety games","ddc":["000"],"publisher":"Elsevier","date_updated":"2021-01-12T07:00:16Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pubrep_id":"388","acknowledgement":"This work was partially supported in part by the NSF grants CCR-0132780, CNS-0720884, CCR-0225610, by the Swiss National Science Foundation, ERC Start Grant Graph Games (Project No. 279307), FWF NFN Grant S11407-N23 (RiSE), and a Microsoft faculty fellows","volume":79,"year":"2013","date_created":"2018-12-11T11:59:57Z","page":"640 - 657","status":"public","project":[{"call_identifier":"FP7","name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425"},{"name":"Game Theory","call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407"},{"name":"Microsoft Research Faculty Fellowship","_id":"2587B514-B435-11E9-9278-68D0E5697425"}],"article_type":"original","_id":"2854","doi":"10.1016/j.jcss.2012.12.001","date_published":"2013-08-01T00:00:00Z","month":"08","publication_status":"published","quality_controlled":"1","oa":1,"intvolume":"        79","publication":"Journal of Computer and System Sciences","file_date_updated":"2020-07-14T12:45:51Z","language":[{"iso":"eng"}],"issue":"5","type":"journal_article","file":[{"file_id":"5370","relation":"main_file","date_created":"2018-12-12T10:18:48Z","creator":"system","file_size":425488,"date_updated":"2020-07-14T12:45:51Z","file_name":"IST-2015-388-v1+1_1-s2.0-S0022000012001778-main.pdf","content_type":"application/pdf","checksum":"6d3ee12cceb946a0abe69594b6a22409","access_level":"open_access"}],"ec_funded":1,"department":[{"_id":"KrCh"},{"_id":"ToHe"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publist_id":"3938","oa_version":"Published Version","author":[{"orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Luca","last_name":"De Alfaro","full_name":"De Alfaro, Luca"},{"orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A","last_name":"Henzinger","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"}]},{"type":"journal_article","issue":"3","language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:45:51Z","month":"03","doi":"10.1016/j.celrep.2013.02.002","date_published":"2013-03-28T00:00:00Z","_id":"2855","publication":"Cell Reports","oa":1,"intvolume":"         3","quality_controlled":"1","publication_status":"published","oa_version":"Published Version","author":[{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Randy","last_name":"Johnson","full_name":"Johnson, Randy"},{"full_name":"Luo, Liqun","last_name":"Luo","first_name":"Liqun"}],"publist_id":"3937","department":[{"_id":"SiHi"}],"file":[{"file_id":"5274","date_created":"2018-12-12T10:17:20Z","relation":"main_file","file_size":1907211,"creator":"system","access_level":"open_access","checksum":"6e977b918e81384cd571ec5a9d812289","content_type":"application/pdf","file_name":"IST-2016-405-v1+1_1-s2.0-S2211124713000612-main.pdf","date_updated":"2020-07-14T12:45:51Z"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"citation":{"apa":"Hippenmeyer, S., Johnson, R., &#38; Luo, L. (2013). Mosaic analysis with double markers reveals cell type specific paternal growth dominance. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2013.02.002\">https://doi.org/10.1016/j.celrep.2013.02.002</a>","chicago":"Hippenmeyer, Simon, Randy Johnson, and Liqun Luo. “Mosaic Analysis with Double Markers Reveals Cell Type Specific Paternal Growth Dominance.” <i>Cell Reports</i>. Cell Press, 2013. <a href=\"https://doi.org/10.1016/j.celrep.2013.02.002\">https://doi.org/10.1016/j.celrep.2013.02.002</a>.","ama":"Hippenmeyer S, Johnson R, Luo L. Mosaic analysis with double markers reveals cell type specific paternal growth dominance. <i>Cell Reports</i>. 2013;3(3):960-967. doi:<a href=\"https://doi.org/10.1016/j.celrep.2013.02.002\">10.1016/j.celrep.2013.02.002</a>","ista":"Hippenmeyer S, Johnson R, Luo L. 2013. Mosaic analysis with double markers reveals cell type specific paternal growth dominance. Cell Reports. 3(3), 960–967.","short":"S. Hippenmeyer, R. Johnson, L. Luo, Cell Reports 3 (2013) 960–967.","ieee":"S. Hippenmeyer, R. Johnson, and L. Luo, “Mosaic analysis with double markers reveals cell type specific paternal growth dominance,” <i>Cell Reports</i>, vol. 3, no. 3. Cell Press, pp. 960–967, 2013.","mla":"Hippenmeyer, Simon, et al. “Mosaic Analysis with Double Markers Reveals Cell Type Specific Paternal Growth Dominance.” <i>Cell Reports</i>, vol. 3, no. 3, Cell Press, 2013, pp. 960–67, doi:<a href=\"https://doi.org/10.1016/j.celrep.2013.02.002\">10.1016/j.celrep.2013.02.002</a>."},"day":"28","abstract":[{"lang":"eng","text":"Genomic imprinting leads to preferred expression of either the maternal or paternal alleles of a subset of genes. Imprinting is essential for mammalian development, and its deregulation causes many diseases. However, the functional relevance of imprinting at the cellular level is poorly understood for most imprinted genes. We used mosaic analysis with double markers (MADM) in mice to create uniparental disomies (UPDs) and to visualize imprinting effects with single-cell resolution. Although chromosome 12 UPD did not produce detectable phenotypes, chromosome 7 UPD caused highly significant paternal growth dominance in the liver and lung, but not in the brain or heart. A single gene on chromosome 7, encoding the secreted insulin-like growth factor 2 (IGF2), accounts for most of the paternal dominance effect. Mosaic analyses implied additional imprinted loci on chromosome 7 acting cell autonomously to transmit the IGF2 signal. Our study reveals chromosome- and cell-type specificity of genomic imprinting effects."}],"scopus_import":1,"has_accepted_license":"1","date_created":"2018-12-11T11:59:57Z","year":"2013","volume":3,"status":"public","page":"960 - 967","title":"Mosaic analysis with double markers reveals cell type specific paternal growth dominance","pubrep_id":"405","date_updated":"2021-01-12T07:00:16Z","publisher":"Cell Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"]},{"date_updated":"2021-01-12T07:00:16Z","publisher":"Nature Publishing Group","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"title":"Optical control of metabotropic glutamate receptors","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681425/"}],"status":"public","page":"507 - 516","date_created":"2018-12-11T11:59:57Z","year":"2013","volume":16,"acknowledgement":"National Science Foundation grants CHE-0233882 and CHE-0840505 (to the College of Chemistry at the University of California, Berkeley), a postdoctoral fellowship of the European Molecular Biology Organization (H.J.)","scopus_import":1,"abstract":[{"text":"G protein–coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we developed an approach for opto-chemical engineering of native GPCRs. We applied this to the metabotropic glutamate receptors (mGluRs) to generate light-agonized and light-antagonized mGluRs (LimGluRs). The light-agonized LimGluR2, on which we focused, was fast, bistable and supported multiple rounds of on/off switching. Light gated two of the primary neuronal functions of mGluR2: suppression of excitability and inhibition of neurotransmitter release. We found that the light-antagonized tool LimGluR2-block was able to manipulate negative feedback of synaptically released glutamate on transmitter release. We generalized the optical control to two additional family members: mGluR3 and mGluR6. This system worked in rodent brain slices and in zebrafish in vivo, where we found that mGluR2 modulated the threshold for escape behavior. These light-gated mGluRs pave the way for determining the roles of mGluRs in synaptic plasticity, memory and disease.","lang":"eng"}],"citation":{"ieee":"J. Levitz <i>et al.</i>, “Optical control of metabotropic glutamate receptors,” <i>Nature Neuroscience</i>, vol. 16. Nature Publishing Group, pp. 507–516, 2013.","mla":"Levitz, Joshua, et al. “Optical Control of Metabotropic Glutamate Receptors.” <i>Nature Neuroscience</i>, vol. 16, Nature Publishing Group, 2013, pp. 507–16, doi:<a href=\"https://doi.org/10.1038/nn.3346\">10.1038/nn.3346</a>.","ista":"Levitz J, Pantoja C, Gaub B, Janovjak HL, Reiner A, Hoagland A, Schoppik D, Kane B, Stawski P, Schier A, Trauner D, Isacoff E. 2013. Optical control of metabotropic glutamate receptors. Nature Neuroscience. 16, 507–516.","chicago":"Levitz, Joshua, Carlos Pantoja, Benjamin Gaub, Harald L Janovjak, Andreas Reiner, Adam Hoagland, David Schoppik, et al. “Optical Control of Metabotropic Glutamate Receptors.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2013. <a href=\"https://doi.org/10.1038/nn.3346\">https://doi.org/10.1038/nn.3346</a>.","ama":"Levitz J, Pantoja C, Gaub B, et al. Optical control of metabotropic glutamate receptors. <i>Nature Neuroscience</i>. 2013;16:507-516. doi:<a href=\"https://doi.org/10.1038/nn.3346\">10.1038/nn.3346</a>","apa":"Levitz, J., Pantoja, C., Gaub, B., Janovjak, H. L., Reiner, A., Hoagland, A., … Isacoff, E. (2013). Optical control of metabotropic glutamate receptors. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn.3346\">https://doi.org/10.1038/nn.3346</a>","short":"J. Levitz, C. Pantoja, B. Gaub, H.L. Janovjak, A. Reiner, A. Hoagland, D. Schoppik, B. Kane, P. Stawski, A. Schier, D. Trauner, E. Isacoff, Nature Neuroscience 16 (2013) 507–516."},"day":"03","department":[{"_id":"HaJa"}],"oa_version":"Submitted Version","author":[{"full_name":"Levitz, Joshua","last_name":"Levitz","first_name":"Joshua"},{"full_name":"Pantoja, Carlos","last_name":"Pantoja","first_name":"Carlos"},{"first_name":"Benjamin","full_name":"Gaub, Benjamin","last_name":"Gaub"},{"orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L","last_name":"Janovjak","first_name":"Harald L","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Reiner, Andreas","last_name":"Reiner","first_name":"Andreas"},{"full_name":"Hoagland, Adam","last_name":"Hoagland","first_name":"Adam"},{"first_name":"David","last_name":"Schoppik","full_name":"Schoppik, David"},{"first_name":"Brian","full_name":"Kane, Brian","last_name":"Kane"},{"full_name":"Stawski, Philipp","last_name":"Stawski","first_name":"Philipp"},{"first_name":"Alexander","full_name":"Schier, Alexander","last_name":"Schier"},{"last_name":"Trauner","full_name":"Trauner, Dirk","first_name":"Dirk"},{"last_name":"Isacoff","full_name":"Isacoff, Ehud","first_name":"Ehud"}],"publist_id":"3936","intvolume":"        16","oa":1,"publication":"Nature Neuroscience","quality_controlled":"1","publication_status":"published","month":"03","external_id":{"pmid":["23455609"]},"date_published":"2013-03-03T00:00:00Z","doi":"10.1038/nn.3346","_id":"2856","type":"journal_article","language":[{"iso":"eng"}]},{"page":"417 - 435","status":"public","project":[{"_id":"255BFFFA-B435-11E9-9278-68D0E5697425","grant_number":"RGY0084/2012","name":"In situ real-time imaging of neurotransmitter signaling using designer optical sensors (HFSP Young Investigator)"},{"_id":"25548C20-B435-11E9-9278-68D0E5697425","grant_number":"303564","name":"Microbial Ion Channels for Synthetic Neurobiology","call_identifier":"FP7"}],"volume":998,"year":"2013","date_created":"2018-12-11T11:59:57Z","ddc":["570"],"date_updated":"2021-01-12T07:00:17Z","publisher":"Springer","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pubrep_id":"834","title":"Optical control of ligand-gated ion channels","abstract":[{"lang":"eng","text":"In the vibrant field of optogenetics, optics and genetic targeting are combined to commandeer cellular functions, such as the neuronal action potential, by optically stimulating light-sensitive ion channels expressed in the cell membrane. One broadly applicable manifestation of this approach are covalently attached photochromic tethered ligands (PTLs) that allow activating ligand-gated ion channels with outstanding spatial and temporal resolution. Here, we describe all steps towards the successful development and application of PTL-gated ion channels in cell lines and primary cells. The basis for these experiments forms a combination of molecular modeling, genetic engineering, cell culture, and electrophysiology. The light-gated glutamate receptor (LiGluR), which consists of the PTL-functionalized GluK2 receptor, serves as a model."}],"day":"22","citation":{"apa":"Szobota, S., Mckenzie, C., &#38; Janovjak, H. L. (2013). Optical control of ligand-gated ion channels. <i>Methods in Molecular Biology</i>. Springer. <a href=\"https://doi.org/10.1007/978-1-62703-351-0_32\">https://doi.org/10.1007/978-1-62703-351-0_32</a>","ama":"Szobota S, Mckenzie C, Janovjak HL. Optical control of ligand-gated ion channels. <i>Methods in Molecular Biology</i>. 2013;998:417-435. doi:<a href=\"https://doi.org/10.1007/978-1-62703-351-0_32\">10.1007/978-1-62703-351-0_32</a>","chicago":"Szobota, Stephanie, Catherine Mckenzie, and Harald L Janovjak. “Optical Control of Ligand-Gated Ion Channels.” <i>Methods in Molecular Biology</i>. Springer, 2013. <a href=\"https://doi.org/10.1007/978-1-62703-351-0_32\">https://doi.org/10.1007/978-1-62703-351-0_32</a>.","ista":"Szobota S, Mckenzie C, Janovjak HL. 2013. Optical control of ligand-gated ion channels. Methods in Molecular Biology. 998, 417–435.","short":"S. Szobota, C. Mckenzie, H.L. Janovjak, Methods in Molecular Biology 998 (2013) 417–435.","ieee":"S. Szobota, C. Mckenzie, and H. L. Janovjak, “Optical control of ligand-gated ion channels,” <i>Methods in Molecular Biology</i>, vol. 998. Springer, pp. 417–435, 2013.","mla":"Szobota, Stephanie, et al. “Optical Control of Ligand-Gated Ion Channels.” <i>Methods in Molecular Biology</i>, vol. 998, Springer, 2013, pp. 417–35, doi:<a href=\"https://doi.org/10.1007/978-1-62703-351-0_32\">10.1007/978-1-62703-351-0_32</a>."},"has_accepted_license":"1","scopus_import":1,"publist_id":"3932","oa_version":"Submitted Version","author":[{"last_name":"Szobota","full_name":"Szobota, Stephanie","first_name":"Stephanie"},{"id":"3EEDE19A-F248-11E8-B48F-1D18A9856A87","first_name":"Catherine","last_name":"Mckenzie","full_name":"Mckenzie, Catherine"},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","first_name":"Harald L","last_name":"Janovjak","orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L"}],"file":[{"date_created":"2018-12-12T10:12:34Z","relation":"main_file","file_id":"4952","file_size":336734,"creator":"system","file_name":"IST-2017-834-v1+1_szobota.pdf","date_updated":"2020-07-14T12:45:51Z","checksum":"1701f0d989f27ddac471b19a894ec0d1","content_type":"application/pdf","access_level":"open_access"}],"ec_funded":1,"department":[{"_id":"HaJa"}],"file_date_updated":"2020-07-14T12:45:51Z","language":[{"iso":"eng"}],"type":"journal_article","alternative_title":["MIMB"],"publication_status":"published","quality_controlled":"1","publication":"Methods in Molecular Biology","intvolume":"       998","oa":1,"_id":"2857","doi":"10.1007/978-1-62703-351-0_32","date_published":"2013-02-22T00:00:00Z","month":"02"}]