[{"volume":100,"main_file_link":[{"url":"https://arxiv.org/abs/1905.09138","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"3","intvolume":"       100","oa":1,"article_number":"035127","scopus_import":"1","month":"07","date_updated":"2024-02-28T13:13:23Z","title":"Floating Wigner crystal with no boundary charge fluctuations","ec_funded":1,"date_published":"2019-07-25T00:00:00Z","article_processing_charge":"No","publication":"Physical Review B","date_created":"2019-11-13T08:41:48Z","external_id":{"isi":["000477888200001"],"arxiv":["1905.09138"]},"project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227","call_identifier":"H2020","name":"Analysis of quantum many-body systems"}],"_id":"7015","language":[{"iso":"eng"}],"status":"public","abstract":[{"text":"We modify the \"floating crystal\" trial state for the classical homogeneous electron gas (also known as jellium), in order to suppress the boundary charge fluctuations that are known to lead to a macroscopic increase of the energy. The argument is to melt a thin layer of the crystal close to the boundary and consequently replace it by an incompressible fluid. With the aid of this trial state we show that three different definitions of the ground-state energy of jellium coincide. In the first point of view the electrons are placed in a neutralizing uniform background. In the second definition there is no background but the electrons are submitted to the constraint that their density is constant, as is appropriate in density functional theory. Finally, in the third system each electron interacts with a periodic image of itself; that is, periodic boundary conditions are imposed on the interaction potential.","lang":"eng"}],"publication_status":"published","quality_controlled":"1","citation":{"ama":"Lewin M, Lieb EH, Seiringer R. Floating Wigner crystal with no boundary charge fluctuations. <i>Physical Review B</i>. 2019;100(3). doi:<a href=\"https://doi.org/10.1103/physrevb.100.035127\">10.1103/physrevb.100.035127</a>","chicago":"Lewin, Mathieu, Elliott H. Lieb, and Robert Seiringer. “Floating Wigner Crystal with No Boundary Charge Fluctuations.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/physrevb.100.035127\">https://doi.org/10.1103/physrevb.100.035127</a>.","mla":"Lewin, Mathieu, et al. “Floating Wigner Crystal with No Boundary Charge Fluctuations.” <i>Physical Review B</i>, vol. 100, no. 3, 035127, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/physrevb.100.035127\">10.1103/physrevb.100.035127</a>.","ista":"Lewin M, Lieb EH, Seiringer R. 2019. Floating Wigner crystal with no boundary charge fluctuations. Physical Review B. 100(3), 035127.","short":"M. Lewin, E.H. Lieb, R. Seiringer, Physical Review B 100 (2019).","apa":"Lewin, M., Lieb, E. H., &#38; Seiringer, R. (2019). Floating Wigner crystal with no boundary charge fluctuations. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.100.035127\">https://doi.org/10.1103/physrevb.100.035127</a>","ieee":"M. Lewin, E. H. Lieb, and R. Seiringer, “Floating Wigner crystal with no boundary charge fluctuations,” <i>Physical Review B</i>, vol. 100, no. 3. American Physical Society, 2019."},"type":"journal_article","article_type":"original","department":[{"_id":"RoSe"}],"publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"isi":1,"author":[{"first_name":"Mathieu","last_name":"Lewin","full_name":"Lewin, Mathieu"},{"full_name":"Lieb, Elliott H.","last_name":"Lieb","first_name":"Elliott H."},{"last_name":"Seiringer","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"year":"2019","arxiv":1,"oa_version":"Preprint","doi":"10.1103/physrevb.100.035127","day":"25","publisher":"American Physical Society"},{"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","has_accepted_license":"1","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"7652"}]},"abstract":[{"text":"Organisms cope with change by employing transcriptional regulators. However, when faced with rare environments, the evolution of transcriptional regulators and their promoters may be too slow. We ask whether the intrinsic instability of gene duplication and amplification provides a generic alternative to canonical gene regulation. By real-time monitoring of gene copy number mutations in E. coli, we show that gene duplications and amplifications enable adaptation to fluctuating environments by rapidly generating copy number, and hence expression level, polymorphism. This ‘amplification-mediated gene expression tuning’ occurs on timescales similar to canonical gene regulation and can deal with rapid environmental changes. Mathematical modeling shows that amplifications also tune gene expression in stochastic environments where transcription factor-based schemes are hard to evolve or maintain. The fleeting nature of gene amplifications gives rise to a generic population-level mechanism that relies on genetic heterogeneity to rapidly tune expression of any gene, without leaving any genomic signature.","lang":"eng"}],"ddc":["576"],"citation":{"ieee":"I. Tomanek, “Data for the paper ‘Gene amplification as a form of population-level gene expression regulation.’” Institute of Science and Technology Austria, 2019.","short":"I. Tomanek, (2019).","apa":"Tomanek, I. (2019). Data for the paper “Gene amplification as a form of population-level gene expression regulation.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:7016\">https://doi.org/10.15479/AT:ISTA:7016</a>","mla":"Tomanek, Isabella. <i>Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation.”</i> Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7016\">10.15479/AT:ISTA:7016</a>.","ista":"Tomanek I. 2019. Data for the paper ‘Gene amplification as a form of population-level gene expression regulation’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:7016\">10.15479/AT:ISTA:7016</a>.","chicago":"Tomanek, Isabella. “Data for the Paper ‘Gene Amplification as a Form of Population-Level Gene Expression Regulation.’” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:7016\">https://doi.org/10.15479/AT:ISTA:7016</a>.","ama":"Tomanek I. Data for the paper “Gene amplification as a form of population-level gene expression regulation.” 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7016\">10.15479/AT:ISTA:7016</a>"},"type":"research_data","file":[{"access_level":"open_access","file_name":"D8_S35_R2_001.fastq","file_size":2456192500,"title":"Locus1_amplified","date_updated":"2020-07-14T12:47:47Z","content_type":"application/octet-stream","checksum":"72441055043eda4cbf1398a422e2c118","relation":"main_file","date_created":"2019-11-13T08:52:21Z","creator":"itomanek","file_id":"7017","description":"Illumina whole genome sequence data for Locus 1 - amplified."},{"file_id":"7018","description":"Illumina whole genome sequence data for Locus 1 - ancestral.","date_created":"2019-11-13T08:52:59Z","creator":"itomanek","relation":"main_file","checksum":"a4ac50bf655d9c751f0305ade5c2ee16","title":"Locus1_ancestral","date_updated":"2020-07-14T12:47:47Z","content_type":"application/octet-stream","file_size":2833452234,"file_name":"IT028_S11_R2_001.fastq","access_level":"open_access"},{"creator":"itomanek","date_created":"2019-11-13T08:54:10Z","file_id":"7019","description":"Illumina whole genome sequence data for Locus 1 - 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Here, we show that the genome-wide transcriptional response to combinations of two drugs, measured at a rigorously controlled growth rate, can predict higher-order antagonism with a third drug in Saccharomyces cerevisiae. Using isogrowth profiling, over 90% of the variation in cellular response can be decomposed into three principal components (PCs) that have clear biological interpretations. We demonstrate that the third PC captures emergent transcriptional programs that are dependent on both drugs and can predict antagonism with a third drug targeting the emergent pathway. We further show that emergent gene expression patterns are most pronounced at a drug ratio where the drug interaction is strongest, providing a guideline for future measurements. Our results provide a readily applicable recipe for uncovering emergent responses in other systems and for higher-order drug combinations. A record of this paper’s transparent peer review process is included in the Supplemental Information.","lang":"eng"}],"language":[{"iso":"eng"}],"status":"public","has_accepted_license":"1","ddc":["570"],"acknowledged_ssus":[{"_id":"LifeSc"}],"article_type":"original","file":[{"file_size":4238460,"content_type":"application/pdf","date_updated":"2020-07-14T12:47:48Z","checksum":"7a11d6c2f9523d65b049512d61733178","relation":"main_file","access_level":"open_access","file_name":"2019_CellSystems_Lukacisin.pdf","file_id":"7027","creator":"dernst","date_created":"2019-11-15T10:57:42Z"}],"citation":{"ieee":"M. Lukacisin and M. T. Bollenbach, “Emergent gene expression responses to drug combinations predict higher-order drug interactions,” <i>Cell Systems</i>, vol. 9, no. 5. Cell Press, pp. 423-433.e1-e3, 2019.","apa":"Lukacisin, M., &#38; Bollenbach, M. T. (2019). Emergent gene expression responses to drug combinations predict higher-order drug interactions. <i>Cell Systems</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cels.2019.10.004\">https://doi.org/10.1016/j.cels.2019.10.004</a>","short":"M. Lukacisin, M.T. Bollenbach, Cell Systems 9 (2019) 423-433.e1-e3.","mla":"Lukacisin, Martin, and Mark Tobias Bollenbach. “Emergent Gene Expression Responses to Drug Combinations Predict Higher-Order Drug Interactions.” <i>Cell Systems</i>, vol. 9, no. 5, Cell Press, 2019, pp. 423-433.e1-e3, doi:<a href=\"https://doi.org/10.1016/j.cels.2019.10.004\">10.1016/j.cels.2019.10.004</a>.","ista":"Lukacisin M, Bollenbach MT. 2019. Emergent gene expression responses to drug combinations predict higher-order drug interactions. Cell Systems. 9(5), 423-433.e1-e3.","chicago":"Lukacisin, Martin, and Mark Tobias Bollenbach. “Emergent Gene Expression Responses to Drug Combinations Predict Higher-Order Drug Interactions.” <i>Cell Systems</i>. Cell Press, 2019. <a href=\"https://doi.org/10.1016/j.cels.2019.10.004\">https://doi.org/10.1016/j.cels.2019.10.004</a>.","ama":"Lukacisin M, Bollenbach MT. Emergent gene expression responses to drug combinations predict higher-order drug interactions. <i>Cell Systems</i>. 2019;9(5):423-433.e1-e3. doi:<a href=\"https://doi.org/10.1016/j.cels.2019.10.004\">10.1016/j.cels.2019.10.004</a>"},"type":"journal_article"},{"citation":{"mla":"Rueda Sanchez, Alfredo R., et al. “Electro-Optic Frequency Comb Generation in Lithium Niobate Whispering Gallery Mode Resonators.” <i>2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference</i>, 8873300, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/cleoe-eqec.2019.8873300\">10.1109/cleoe-eqec.2019.8873300</a>.","ista":"Rueda Sanchez AR, Sedlmeir F, Leuchs G, Kuamri M, Schwefel HGL. 2019. Electro-optic frequency comb generation in lithium niobate whispering gallery mode resonators. 2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference. CLEO: Conference on Lasers and Electro-Optics Europe, 8873300.","ama":"Rueda Sanchez AR, Sedlmeir F, Leuchs G, Kuamri M, Schwefel HGL. Electro-optic frequency comb generation in lithium niobate whispering gallery mode resonators. In: <i>2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/cleoe-eqec.2019.8873300\">10.1109/cleoe-eqec.2019.8873300</a>","chicago":"Rueda Sanchez, Alfredo R, Florian Sedlmeir, Gerd Leuchs, Madhuri Kuamri, and Harald G. L. Schwefel. “Electro-Optic Frequency Comb Generation in Lithium Niobate Whispering Gallery Mode Resonators.” In <i>2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/cleoe-eqec.2019.8873300\">https://doi.org/10.1109/cleoe-eqec.2019.8873300</a>.","ieee":"A. R. Rueda Sanchez, F. Sedlmeir, G. Leuchs, M. Kuamri, and H. G. L. Schwefel, “Electro-optic frequency comb generation in lithium niobate whispering gallery mode resonators,” in <i>2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference</i>, Munich, Germany, 2019.","apa":"Rueda Sanchez, A. R., Sedlmeir, F., Leuchs, G., Kuamri, M., &#38; Schwefel, H. G. L. (2019). Electro-optic frequency comb generation in lithium niobate whispering gallery mode resonators. In <i>2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference</i>. Munich, Germany: IEEE. <a href=\"https://doi.org/10.1109/cleoe-eqec.2019.8873300\">https://doi.org/10.1109/cleoe-eqec.2019.8873300</a>","short":"A.R. Rueda Sanchez, F. Sedlmeir, G. Leuchs, M. Kuamri, H.G.L. Schwefel, in:, 2019 Conference on Lasers and Electro-Optics Europe &#38; European Quantum Electronics Conference, IEEE, 2019."},"scopus_import":"1","type":"conference","abstract":[{"lang":"eng","text":"Optical frequency combs (OFCs) are light sources whose spectra consists of equally spaced frequency lines in the optical domain [1]. They have great potential for improving high-capacity data transfer, all-optical atomic clocks, spectroscopy, and high-precision measurements [2]."}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","article_number":"8873300","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference","doi":"10.1109/cleoe-eqec.2019.8873300","oa_version":"None","_id":"7032","publisher":"IEEE","external_id":{"isi":["000630002701617"]},"day":"17","date_created":"2019-11-18T13:58:22Z","department":[{"_id":"JoFi"}],"publication_identifier":{"isbn":["9781728104690"]},"title":"Electro-optic frequency comb generation in lithium niobate whispering gallery mode resonators","date_updated":"2023-08-30T07:26:01Z","month":"10","year":"2019","conference":{"name":"CLEO: Conference on Lasers and Electro-Optics Europe","start_date":"2019-06-23","location":"Munich, Germany","end_date":"2019-06-27"},"article_processing_charge":"No","isi":1,"author":[{"last_name":"Rueda Sanchez","full_name":"Rueda Sanchez, Alfredo R","orcid":"0000-0001-6249-5860","first_name":"Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sedlmeir","full_name":"Sedlmeir, Florian","first_name":"Florian"},{"first_name":"Gerd","last_name":"Leuchs","full_name":"Leuchs, Gerd"},{"full_name":"Kuamri, Madhuri","last_name":"Kuamri","first_name":"Madhuri"},{"last_name":"Schwefel","full_name":"Schwefel, Harald G. L.","first_name":"Harald G. L."}],"date_published":"2019-10-17T00:00:00Z"},{"scopus_import":"1","volume":39,"main_file_link":[{"url":"https://arxiv.org/abs/1709.00508","open_access":"1"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"6","oa":1,"intvolume":"        39","publication":"Combinatorica","page":"1267-1279","_id":"7034","project":[{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"},{"name":"Eliminating intersections in drawings of graphs","call_identifier":"FWF","grant_number":"M02281","_id":"261FA626-B435-11E9-9278-68D0E5697425"}],"date_created":"2019-11-18T14:29:50Z","external_id":{"arxiv":["1709.00508"],"isi":["000493267200003"]},"title":"Counterexample to an extension of the Hanani-Tutte theorem on the surface of genus 4","date_updated":"2023-08-30T07:26:25Z","month":"10","date_published":"2019-10-29T00:00:00Z","article_processing_charge":"No","ec_funded":1,"type":"journal_article","citation":{"chicago":"Fulek, Radoslav, and Jan Kynčl. “Counterexample to an Extension of the Hanani-Tutte Theorem on the Surface of Genus 4.” <i>Combinatorica</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/s00493-019-3905-7\">https://doi.org/10.1007/s00493-019-3905-7</a>.","ama":"Fulek R, Kynčl J. Counterexample to an extension of the Hanani-Tutte theorem on the surface of genus 4. <i>Combinatorica</i>. 2019;39(6):1267-1279. doi:<a href=\"https://doi.org/10.1007/s00493-019-3905-7\">10.1007/s00493-019-3905-7</a>","ista":"Fulek R, Kynčl J. 2019. Counterexample to an extension of the Hanani-Tutte theorem on the surface of genus 4. Combinatorica. 39(6), 1267–1279.","mla":"Fulek, Radoslav, and Jan Kynčl. “Counterexample to an Extension of the Hanani-Tutte Theorem on the Surface of Genus 4.” <i>Combinatorica</i>, vol. 39, no. 6, Springer Nature, 2019, pp. 1267–79, doi:<a href=\"https://doi.org/10.1007/s00493-019-3905-7\">10.1007/s00493-019-3905-7</a>.","apa":"Fulek, R., &#38; Kynčl, J. (2019). Counterexample to an extension of the Hanani-Tutte theorem on the surface of genus 4. <i>Combinatorica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00493-019-3905-7\">https://doi.org/10.1007/s00493-019-3905-7</a>","short":"R. Fulek, J. Kynčl, Combinatorica 39 (2019) 1267–1279.","ieee":"R. Fulek and J. Kynčl, “Counterexample to an extension of the Hanani-Tutte theorem on the surface of genus 4,” <i>Combinatorica</i>, vol. 39, no. 6. Springer Nature, pp. 1267–1279, 2019."},"article_type":"original","publication_status":"published","abstract":[{"text":"We find a graph of genus 5 and its drawing on the orientable surface of genus 4 with every pair of independent edges crossing an even number of times. This shows that the strong Hanani–Tutte theorem cannot be extended to the orientable surface of genus 4. As a base step in the construction we use a counterexample to an extension of the unified Hanani–Tutte theorem on the torus.","lang":"eng"}],"language":[{"iso":"eng"}],"status":"public","quality_controlled":"1","doi":"10.1007/s00493-019-3905-7","arxiv":1,"oa_version":"Preprint","publisher":"Springer Nature","day":"29","department":[{"_id":"UlWa"}],"publication_identifier":{"issn":["0209-9683"],"eissn":["1439-6912"]},"isi":1,"author":[{"full_name":"Fulek, Radoslav","orcid":"0000-0001-8485-1774","last_name":"Fulek","id":"39F3FFE4-F248-11E8-B48F-1D18A9856A87","first_name":"Radoslav"},{"last_name":"Kynčl","full_name":"Kynčl, Jan","first_name":"Jan"}],"year":"2019"},{"type":"conference","citation":{"chicago":"Geher, Gyorgy Pal, Tamas Titkos, and Daniel Virosztek. “Dirac Masses and Isometric Rigidity.” In <i>Kyoto RIMS Kôkyûroku</i>, 2125:34–41. Research Institute for Mathematical Sciences, Kyoto University, 2019.","ama":"Geher GP, Titkos T, Virosztek D. Dirac masses and isometric rigidity. In: <i>Kyoto RIMS Kôkyûroku</i>. Vol 2125. Research Institute for Mathematical Sciences, Kyoto University; 2019:34-41.","ista":"Geher GP, Titkos T, Virosztek D. 2019. Dirac masses and isometric rigidity. Kyoto RIMS Kôkyûroku. Research on isometries as preserver problems and related topics vol. 2125, 34–41.","mla":"Geher, Gyorgy Pal, et al. “Dirac Masses and Isometric Rigidity.” <i>Kyoto RIMS Kôkyûroku</i>, vol. 2125, Research Institute for Mathematical Sciences, Kyoto University, 2019, pp. 34–41.","short":"G.P. Geher, T. Titkos, D. Virosztek, in:, Kyoto RIMS Kôkyûroku, Research Institute for Mathematical Sciences, Kyoto University, 2019, pp. 34–41.","apa":"Geher, G. P., Titkos, T., &#38; Virosztek, D. (2019). Dirac masses and isometric rigidity. In <i>Kyoto RIMS Kôkyûroku</i> (Vol. 2125, pp. 34–41). Kyoto, Japan: Research Institute for Mathematical Sciences, Kyoto University.","ieee":"G. P. Geher, T. Titkos, and D. Virosztek, “Dirac masses and isometric rigidity,” in <i>Kyoto RIMS Kôkyûroku</i>, Kyoto, Japan, 2019, vol. 2125, pp. 34–41."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"      2125","oa":1,"quality_controlled":"1","language":[{"iso":"eng"}],"status":"public","volume":2125,"publication_status":"published","abstract":[{"text":"The aim of this short note is to expound one particular issue that was discussed during the talk [10] given at the symposium ”Researches on isometries as preserver problems and related topics” at Kyoto RIMS. That is,  the role of Dirac masses by  describing  the  isometry group of various metric spaces  of probability  measures.   This  article  is  of  survey  character,  and  it  does  not  contain  any  essentially  new results.From an isometric point of view, in some cases, metric spaces of measures are similar to C(K)-type function  spaces.   Similarity  means  here  that  their  isometries  are  driven  by  some  nice  transformations of  the  underlying  space.   Of  course,  it  depends  on  the  particular  choice  of  the  metric  how  nice  these transformations should be.  Sometimes, as we will see, being a homeomorphism is enough to generate an isometry.  But sometimes we need more:  the transformation must preserve the underlying distance as well.  Statements claiming that isometries in questions are necessarily induced by homeomorphisms are called Banach-Stone-type results, while results asserting that the underlying transformation is necessarily an isometry are termed as isometric rigidity results.As  Dirac  masses  can  be  considered  as  building  bricks  of  the  set  of  all  Borel  measures,  a  natural question arises:Is it enough to understand how an isometry acts on the set of Dirac masses?  Does this action extend uniquely to all measures?In what follows, we will thoroughly investigate this question.","lang":"eng"}],"main_file_link":[{"url":"http://www.kurims.kyoto-u.ac.jp/~kyodo/kokyuroku/contents/2125.html","open_access":"1"}],"date_created":"2019-11-18T15:39:53Z","day":"30","publisher":"Research Institute for Mathematical Sciences, Kyoto University","_id":"7035","page":"34-41","oa_version":"Submitted Version","publication":"Kyoto RIMS Kôkyûroku","author":[{"first_name":"Gyorgy Pal","last_name":"Geher","full_name":"Geher, Gyorgy Pal"},{"first_name":"Tamas","full_name":"Titkos, Tamas","last_name":"Titkos"},{"last_name":"Virosztek","full_name":"Virosztek, Daniel","orcid":"0000-0003-1109-5511","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel"}],"date_published":"2019-01-30T00:00:00Z","conference":{"end_date":"2019-01-30","location":"Kyoto, Japan","start_date":"2019-01-28","name":"Research on isometries as preserver problems and related topics"},"article_processing_charge":"No","year":"2019","month":"01","date_updated":"2021-01-12T08:11:33Z","title":"Dirac masses and isometric rigidity","department":[{"_id":"LaEr"}]},{"related_material":{"record":[{"id":"285","status":"public","relation":"earlier_version"},{"status":"public","relation":"part_of_dissertation","id":"8032"}]},"volume":10,"oa":1,"intvolume":"        10","issue":"2","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"11","title":"On the treewidth of triangulated 3-manifolds","date_updated":"2023-09-07T13:18:26Z","article_processing_charge":"No","date_published":"2019-11-01T00:00:00Z","page":"70–98","publication":"Journal of Computational Geometry","file_date_updated":"2020-07-14T12:47:49Z","external_id":{"arxiv":["1712.00434"]},"date_created":"2019-11-23T12:14:09Z","_id":"7093","has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"abstract":[{"text":"In graph theory, as well as in 3-manifold topology, there exist several width-type parameters to describe how \"simple\" or \"thin\" a given graph or 3-manifold is. These parameters, such as pathwidth or treewidth for graphs, or the concept of thin position for 3-manifolds, play an important role when studying algorithmic problems; in particular, there is a variety of problems in computational 3-manifold topology - some of them known to be computationally hard in general - that become solvable in polynomial time as soon as the dual graph of the input triangulation has bounded treewidth.\r\nIn view of these algorithmic results, it is natural to ask whether every 3-manifold admits a triangulation of bounded treewidth. We show that this is not the case, i.e., that there exists an infinite family of closed 3-manifolds not admitting triangulations of bounded pathwidth or treewidth (the latter implies the former, but we present two separate proofs).\r\nWe derive these results from work of Agol, of Scharlemann and Thompson, and of Scharlemann, Schultens and Saito by exhibiting explicit connections between the topology of a 3-manifold M on the one hand and width-type parameters of the dual graphs of triangulations of M on the other hand, answering a question that had been raised repeatedly by researchers in computational 3-manifold topology. In particular, we show that if a closed, orientable, irreducible, non-Haken 3-manifold M has a triangulation of treewidth (resp. pathwidth) k then the Heegaard genus of M is at most 18(k+1) (resp. 4(3k+1)).","lang":"eng"}],"publication_status":"published","quality_controlled":"1","citation":{"mla":"Huszár, Kristóf, et al. “On the Treewidth of Triangulated 3-Manifolds.” <i>Journal of Computational Geometry</i>, vol. 10, no. 2, Computational Geometry Laborartoy, 2019, pp. 70–98, doi:<a href=\"https://doi.org/10.20382/JOGC.V10I2A5\">10.20382/JOGC.V10I2A5</a>.","ista":"Huszár K, Spreer J, Wagner U. 2019. On the treewidth of triangulated 3-manifolds. Journal of Computational Geometry. 10(2), 70–98.","chicago":"Huszár, Kristóf, Jonathan Spreer, and Uli Wagner. “On the Treewidth of Triangulated 3-Manifolds.” <i>Journal of Computational Geometry</i>. Computational Geometry Laborartoy, 2019. <a href=\"https://doi.org/10.20382/JOGC.V10I2A5\">https://doi.org/10.20382/JOGC.V10I2A5</a>.","ama":"Huszár K, Spreer J, Wagner U. On the treewidth of triangulated 3-manifolds. <i>Journal of Computational Geometry</i>. 2019;10(2):70–98. doi:<a href=\"https://doi.org/10.20382/JOGC.V10I2A5\">10.20382/JOGC.V10I2A5</a>","ieee":"K. Huszár, J. Spreer, and U. Wagner, “On the treewidth of triangulated 3-manifolds,” <i>Journal of Computational Geometry</i>, vol. 10, no. 2. Computational Geometry Laborartoy, pp. 70–98, 2019.","apa":"Huszár, K., Spreer, J., &#38; Wagner, U. (2019). On the treewidth of triangulated 3-manifolds. <i>Journal of Computational Geometry</i>. Computational Geometry Laborartoy. <a href=\"https://doi.org/10.20382/JOGC.V10I2A5\">https://doi.org/10.20382/JOGC.V10I2A5</a>","short":"K. Huszár, J. Spreer, U. Wagner, Journal of Computational Geometry 10 (2019) 70–98."},"type":"journal_article","file":[{"access_level":"open_access","file_name":"479-1917-1-PB.pdf","file_size":857590,"content_type":"application/pdf","date_updated":"2020-07-14T12:47:49Z","checksum":"c872d590d38d538404782bca20c4c3f5","relation":"main_file","creator":"khuszar","date_created":"2019-11-23T12:35:16Z","file_id":"7094"}],"article_type":"original","ddc":["514"],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"UlWa"}],"publication_identifier":{"issn":["1920-180X"]},"year":"2019","author":[{"full_name":"Huszár, Kristóf","orcid":"0000-0002-5445-5057","last_name":"Huszár","id":"33C26278-F248-11E8-B48F-1D18A9856A87","first_name":"Kristóf"},{"first_name":"Jonathan","full_name":"Spreer, Jonathan","last_name":"Spreer"},{"last_name":"Wagner","full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli"}],"arxiv":1,"oa_version":"Published Version","doi":"10.20382/JOGC.V10I2A5","day":"01","publisher":"Computational Geometry Laborartoy"},{"publication_identifier":{"eissn":["2045-2322"]},"department":[{"_id":"SaSi"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"year":"2019","isi":1,"author":[{"full_name":"Maes, Margaret E","orcid":"0000-0001-9642-1085","last_name":"Maes","id":"3838F452-F248-11E8-B48F-1D18A9856A87","first_name":"Margaret E"},{"first_name":"J. A.","full_name":"Grosser, J. A.","last_name":"Grosser"},{"full_name":"Fehrman, R. L.","last_name":"Fehrman","first_name":"R. L."},{"full_name":"Schlamp, C. L.","last_name":"Schlamp","first_name":"C. L."},{"first_name":"R. W.","last_name":"Nickells","full_name":"Nickells, R. W."}],"doi":"10.1038/s41598-019-53049-w","oa_version":"Published Version","publisher":"Springer Nature","day":"12","abstract":[{"lang":"eng","text":"BAX, a member of the BCL2 gene family, controls the committed step of the intrinsic apoptotic program. Mitochondrial fragmentation is a commonly observed feature of apoptosis, which occurs through the process of mitochondrial fission. BAX has consistently been associated with mitochondrial fission, yet how BAX participates in the process of mitochondrial fragmentation during apoptosis remains to be tested. Time-lapse imaging of BAX recruitment and mitochondrial fragmentation demonstrates that rapid mitochondrial fragmentation during apoptosis occurs after the complete recruitment of BAX to the mitochondrial outer membrane (MOM). The requirement of a fully functioning BAX protein for the fission process was demonstrated further in BAX/BAK-deficient HCT116 cells expressing a P168A mutant of BAX. The mutant performed fusion to restore the mitochondrial network. but was not demonstrably recruited to the MOM after apoptosis induction. Under these conditions, mitochondrial fragmentation was blocked. Additionally, we show that loss of the fission protein, dynamin-like protein 1 (DRP1), does not temporally affect the initiation time or rate of BAX recruitment, but does reduce the final level of BAX recruited to the MOM during the late phase of BAX recruitment. These correlative observations suggest a model where late-stage BAX oligomers play a functional part of the mitochondrial fragmentation machinery in apoptotic cells."}],"publication_status":"published","pmid":1,"status":"public","has_accepted_license":"1","language":[{"iso":"eng"}],"quality_controlled":"1","file":[{"file_id":"7096","creator":"dernst","date_created":"2019-11-25T07:49:52Z","checksum":"9ab397ed9c1c454b34bffb8cc863d734","relation":"main_file","file_size":6467393,"date_updated":"2020-07-14T12:47:49Z","content_type":"application/pdf","file_name":"2019_ScientificReports_Maes.pdf","access_level":"open_access"}],"type":"journal_article","citation":{"ieee":"M. E. Maes, J. A. Grosser, R. L. Fehrman, C. L. Schlamp, and R. W. Nickells, “Completion of BAX recruitment correlates with mitochondrial fission during apoptosis,” <i>Scientific Reports</i>, vol. 9. Springer Nature, 2019.","short":"M.E. Maes, J.A. Grosser, R.L. Fehrman, C.L. Schlamp, R.W. Nickells, Scientific Reports 9 (2019).","apa":"Maes, M. E., Grosser, J. A., Fehrman, R. L., Schlamp, C. L., &#38; Nickells, R. W. (2019). Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-019-53049-w\">https://doi.org/10.1038/s41598-019-53049-w</a>","mla":"Maes, Margaret E., et al. “Completion of BAX Recruitment Correlates with Mitochondrial Fission during Apoptosis.” <i>Scientific Reports</i>, vol. 9, 16565, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41598-019-53049-w\">10.1038/s41598-019-53049-w</a>.","ista":"Maes ME, Grosser JA, Fehrman RL, Schlamp CL, Nickells RW. 2019. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. Scientific Reports. 9, 16565.","ama":"Maes ME, Grosser JA, Fehrman RL, Schlamp CL, Nickells RW. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. <i>Scientific Reports</i>. 2019;9. doi:<a href=\"https://doi.org/10.1038/s41598-019-53049-w\">10.1038/s41598-019-53049-w</a>","chicago":"Maes, Margaret E, J. A. Grosser, R. L. Fehrman, C. L. Schlamp, and R. W. Nickells. “Completion of BAX Recruitment Correlates with Mitochondrial Fission during Apoptosis.” <i>Scientific Reports</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41598-019-53049-w\">https://doi.org/10.1038/s41598-019-53049-w</a>."},"ddc":["570"],"article_type":"original","date_updated":"2023-08-30T07:26:54Z","title":"Completion of BAX recruitment correlates with mitochondrial fission during apoptosis","month":"11","article_processing_charge":"No","date_published":"2019-11-12T00:00:00Z","publication":"Scientific Reports","file_date_updated":"2020-07-14T12:47:49Z","_id":"7095","external_id":{"pmid":["31719602"],"isi":["000495857600019"]},"date_created":"2019-11-25T07:45:17Z","volume":9,"article_number":"16565","intvolume":"         9","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","scopus_import":"1"},{"external_id":{"isi":["000496767800005"]},"date_created":"2019-11-25T07:55:01Z","_id":"7097","publication":"Communications Biology","file_date_updated":"2020-07-14T12:47:49Z","article_processing_charge":"No","date_published":"2019-11-15T00:00:00Z","month":"11","date_updated":"2023-08-30T07:27:55Z","title":"Rab5-mediated endosome formation is regulated at the trans-Golgi network","scopus_import":"1","intvolume":"         2","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"1","article_number":"419","volume":2,"day":"15","publisher":"Springer Nature","oa_version":"Published Version","doi":"10.1038/s42003-019-0670-5","year":"2019","author":[{"first_name":"Makoto","full_name":"Nagano, Makoto","last_name":"Nagano"},{"first_name":"Junko Y.","full_name":"Toshima, Junko Y.","last_name":"Toshima"},{"last_name":"Siekhaus","orcid":"0000-0001-8323-8353","full_name":"Siekhaus, Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","first_name":"Daria E"},{"full_name":"Toshima, Jiro","last_name":"Toshima","first_name":"Jiro"}],"isi":1,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["2399-3642"]},"department":[{"_id":"DaSi"}],"article_type":"original","ddc":["570"],"citation":{"short":"M. Nagano, J.Y. Toshima, D.E. Siekhaus, J. Toshima, Communications Biology 2 (2019).","apa":"Nagano, M., Toshima, J. Y., Siekhaus, D. E., &#38; Toshima, J. (2019). Rab5-mediated endosome formation is regulated at the trans-Golgi network. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-019-0670-5\">https://doi.org/10.1038/s42003-019-0670-5</a>","ieee":"M. Nagano, J. Y. Toshima, D. E. Siekhaus, and J. Toshima, “Rab5-mediated endosome formation is regulated at the trans-Golgi network,” <i>Communications Biology</i>, vol. 2, no. 1. Springer Nature, 2019.","ama":"Nagano M, Toshima JY, Siekhaus DE, Toshima J. Rab5-mediated endosome formation is regulated at the trans-Golgi network. <i>Communications Biology</i>. 2019;2(1). doi:<a href=\"https://doi.org/10.1038/s42003-019-0670-5\">10.1038/s42003-019-0670-5</a>","chicago":"Nagano, Makoto, Junko Y. Toshima, Daria E Siekhaus, and Jiro Toshima. “Rab5-Mediated Endosome Formation Is Regulated at the Trans-Golgi Network.” <i>Communications Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s42003-019-0670-5\">https://doi.org/10.1038/s42003-019-0670-5</a>.","mla":"Nagano, Makoto, et al. “Rab5-Mediated Endosome Formation Is Regulated at the Trans-Golgi Network.” <i>Communications Biology</i>, vol. 2, no. 1, 419, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s42003-019-0670-5\">10.1038/s42003-019-0670-5</a>.","ista":"Nagano M, Toshima JY, Siekhaus DE, Toshima J. 2019. Rab5-mediated endosome formation is regulated at the trans-Golgi network. Communications Biology. 2(1), 419."},"type":"journal_article","file":[{"file_id":"7098","creator":"dernst","date_created":"2019-11-25T07:58:05Z","relation":"main_file","checksum":"c63c69a264fc8a0e52f2b0d482f3bdae","date_updated":"2020-07-14T12:47:49Z","content_type":"application/pdf","file_size":2626069,"file_name":"2019_CommunicBiology_Nagano.pdf","access_level":"open_access"}],"quality_controlled":"1","has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"text":"Early endosomes, also called sorting endosomes, are known to mature into late endosomesvia the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence isthought to be maintained by the continual fusion of transport vesicles from the plasmamembrane and thetrans-Golgi network (TGN). Here we show instead that endocytosis isdispensable and post-Golgi vesicle transport is crucial for the formation of endosomes andthe subsequent endolysosomal traffic regulated by yeast Rab5 Vps21p. Fittingly, all threeproteins required for endosomal nucleotide exchange on Vps21p arefirst recruited to theTGN  before  transport  to  the  endosome,  namely  the  GEF  Vps9p and  the  epsin-relatedadaptors Ent3/5p. The TGN recruitment of these components is distinctly controlled, withVps9p appearing to require the Arf1p GTPase, and the Rab11s, Ypt31p/32p. These resultsprovide a different view of endosome formation and identify the TGN as a critical location forregulating progress through the endolysosomal trafficking pathway.","lang":"eng"}]},{"day":"20","publisher":"Elsevier","oa_version":"Published Version","doi":"10.1016/j.neuron.2019.08.013","year":"2019","author":[{"last_name":"Kasugai","full_name":"Kasugai, Yu","first_name":"Yu"},{"first_name":"Elisabeth","last_name":"Vogel","full_name":"Vogel, Elisabeth"},{"last_name":"Hörtnagl","full_name":"Hörtnagl, Heide","first_name":"Heide"},{"first_name":"Sabine","last_name":"Schönherr","full_name":"Schönherr, Sabine"},{"first_name":"Enrica","full_name":"Paradiso, Enrica","last_name":"Paradiso"},{"first_name":"Markus","full_name":"Hauschild, Markus","last_name":"Hauschild"},{"last_name":"Göbel","full_name":"Göbel, Georg","first_name":"Georg"},{"last_name":"Milenkovic","full_name":"Milenkovic, Ivan","first_name":"Ivan"},{"first_name":"Yvan","last_name":"Peterschmitt","full_name":"Peterschmitt, Yvan"},{"last_name":"Tasan","full_name":"Tasan, Ramon","first_name":"Ramon"},{"full_name":"Sperk, Günther","last_name":"Sperk","first_name":"Günther"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"last_name":"Sieghart","full_name":"Sieghart, Werner","first_name":"Werner"},{"first_name":"Nicolas","full_name":"Singewald, Nicolas","last_name":"Singewald"},{"full_name":"Lüthi, Andreas","last_name":"Lüthi","first_name":"Andreas"},{"last_name":"Ferraguti","full_name":"Ferraguti, Francesco","first_name":"Francesco"}],"isi":1,"department":[{"_id":"RySh"}],"publication_identifier":{"issn":["0896-6273"]},"article_type":"original","ddc":["571","599"],"citation":{"short":"Y. Kasugai, E. Vogel, H. Hörtnagl, S. Schönherr, E. Paradiso, M. Hauschild, G. Göbel, I. Milenkovic, Y. Peterschmitt, R. Tasan, G. Sperk, R. Shigemoto, W. Sieghart, N. Singewald, A. Lüthi, F. Ferraguti, Neuron 104 (2019) 781–794.e4.","apa":"Kasugai, Y., Vogel, E., Hörtnagl, H., Schönherr, S., Paradiso, E., Hauschild, M., … Ferraguti, F. (2019). Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2019.08.013\">https://doi.org/10.1016/j.neuron.2019.08.013</a>","ieee":"Y. Kasugai <i>et al.</i>, “Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning,” <i>Neuron</i>, vol. 104, no. 4. Elsevier, p. 781–794.e4, 2019.","chicago":"Kasugai, Yu, Elisabeth Vogel, Heide Hörtnagl, Sabine Schönherr, Enrica Paradiso, Markus Hauschild, Georg Göbel, et al. “Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning.” <i>Neuron</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.neuron.2019.08.013\">https://doi.org/10.1016/j.neuron.2019.08.013</a>.","ama":"Kasugai Y, Vogel E, Hörtnagl H, et al. Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. <i>Neuron</i>. 2019;104(4):781-794.e4. doi:<a href=\"https://doi.org/10.1016/j.neuron.2019.08.013\">10.1016/j.neuron.2019.08.013</a>","ista":"Kasugai Y, Vogel E, Hörtnagl H, Schönherr S, Paradiso E, Hauschild M, Göbel G, Milenkovic I, Peterschmitt Y, Tasan R, Sperk G, Shigemoto R, Sieghart W, Singewald N, Lüthi A, Ferraguti F. 2019. Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. Neuron. 104(4), 781–794.e4.","mla":"Kasugai, Yu, et al. “Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning.” <i>Neuron</i>, vol. 104, no. 4, Elsevier, 2019, p. 781–794.e4, doi:<a href=\"https://doi.org/10.1016/j.neuron.2019.08.013\">10.1016/j.neuron.2019.08.013</a>."},"type":"journal_article","quality_controlled":"1","pmid":1,"has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"publication_status":"published","external_id":{"isi":["000497963500017"],"pmid":["31543297"]},"date_created":"2019-11-25T08:02:39Z","_id":"7099","page":"781-794.e4","publication":"Neuron","article_processing_charge":"No","date_published":"2019-11-20T00:00:00Z","month":"11","date_updated":"2023-08-30T07:28:22Z","title":"Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning","scopus_import":"1","intvolume":"       104","oa":1,"acknowledgement":"The authors thank Gabi Schmid for excellent technical support. We also thank\r\nDr. H. Harada, Dr. W. Kaufmann, and Dr. B. Kapelari for testing the specificity\r\nof some of the antibodies used in this study on replicas. Funding was provided\r\nby the Austrian Science Fund (Fonds zur Fo¨ rderung der Wissenschaftlichen\r\nForschung) Sonderforschungsbereich grants F44-17 (to F.jF.), F44-10 and\r\nP25375-B24 (to N.S.), and P26680 (to G.S.) and by the Novartis Research\r\nFoundation and the Swiss National Science Foundation (to A.L). We also thank\r\nProf. M. Capogna for reading a previous version of the manuscript.","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"4","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2019.08.013"}],"volume":104},{"doi":"10.1007/s00220-019-03599-x","oa_version":"Published Version","publisher":"Springer Nature","day":"08","publication_identifier":{"issn":["0010-3616"],"eissn":["1432-0916"]},"department":[{"_id":"RoSe"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"year":"2019","author":[{"full_name":"Jeblick, Maximilian","last_name":"Jeblick","first_name":"Maximilian"},{"first_name":"Nikolai K","id":"4BC40BEC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0495-6822","full_name":"Leopold, Nikolai K","last_name":"Leopold"},{"first_name":"Peter","full_name":"Pickl, Peter","last_name":"Pickl"}],"isi":1,"file":[{"date_created":"2019-11-25T08:11:11Z","creator":"dernst","file_id":"7101","file_name":"2019_CommMathPhys_Jeblick.pdf","access_level":"open_access","checksum":"cd283b475dd739e04655315abd46f528","relation":"main_file","content_type":"application/pdf","date_updated":"2020-07-14T12:47:49Z","file_size":884469}],"type":"journal_article","citation":{"ama":"Jeblick M, Leopold NK, Pickl P. Derivation of the time dependent Gross–Pitaevskii equation in two dimensions. <i>Communications in Mathematical Physics</i>. 2019;372(1):1-69. doi:<a href=\"https://doi.org/10.1007/s00220-019-03599-x\">10.1007/s00220-019-03599-x</a>","chicago":"Jeblick, Maximilian, Nikolai K Leopold, and Peter Pickl. “Derivation of the Time Dependent Gross–Pitaevskii Equation in Two Dimensions.” <i>Communications in Mathematical Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/s00220-019-03599-x\">https://doi.org/10.1007/s00220-019-03599-x</a>.","ista":"Jeblick M, Leopold NK, Pickl P. 2019. Derivation of the time dependent Gross–Pitaevskii equation in two dimensions. Communications in Mathematical Physics. 372(1), 1–69.","mla":"Jeblick, Maximilian, et al. “Derivation of the Time Dependent Gross–Pitaevskii Equation in Two Dimensions.” <i>Communications in Mathematical Physics</i>, vol. 372, no. 1, Springer Nature, 2019, pp. 1–69, doi:<a href=\"https://doi.org/10.1007/s00220-019-03599-x\">10.1007/s00220-019-03599-x</a>.","apa":"Jeblick, M., Leopold, N. K., &#38; Pickl, P. (2019). Derivation of the time dependent Gross–Pitaevskii equation in two dimensions. <i>Communications in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00220-019-03599-x\">https://doi.org/10.1007/s00220-019-03599-x</a>","short":"M. Jeblick, N.K. Leopold, P. Pickl, Communications in Mathematical Physics 372 (2019) 1–69.","ieee":"M. Jeblick, N. K. Leopold, and P. Pickl, “Derivation of the time dependent Gross–Pitaevskii equation in two dimensions,” <i>Communications in Mathematical Physics</i>, vol. 372, no. 1. Springer Nature, pp. 1–69, 2019."},"ddc":["510"],"article_type":"original","abstract":[{"lang":"eng","text":"We present microscopic derivations of the defocusing two-dimensional cubic nonlinear Schrödinger equation and the Gross–Pitaevskii equation starting froman interacting N-particle system of bosons. We consider the interaction potential to be given either by Wβ(x)=N−1+2βW(Nβx), for any β>0, or to be given by VN(x)=e2NV(eNx), for some spherical symmetric, nonnegative and compactly supported W,V∈L∞(R2,R). In both cases we prove the convergence of the reduced density corresponding to the exact time evolution to the projector onto the solution of the corresponding nonlinear Schrödinger equation in trace norm. For the latter potential VN we show that it is crucial to take the microscopic structure of the condensate into account in order to obtain the correct dynamics."}],"publication_status":"published","has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","publication":"Communications in Mathematical Physics","file_date_updated":"2020-07-14T12:47:49Z","page":"1-69","_id":"7100","project":[{"call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227","name":"Analysis of quantum many-body systems"},{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"external_id":{"isi":["000495193700002"]},"date_created":"2019-11-25T08:08:02Z","date_updated":"2023-09-06T10:47:43Z","title":"Derivation of the time dependent Gross–Pitaevskii equation in two dimensions","month":"11","article_processing_charge":"Yes (via OA deal)","date_published":"2019-11-08T00:00:00Z","ec_funded":1,"scopus_import":"1","volume":372,"intvolume":"       372","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"1","acknowledgement":"OA fund by IST Austria"},{"scopus_import":"1","volume":15,"issue":"11","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        15","oa":1,"article_number":"e1007268","file_date_updated":"2020-07-14T12:47:49Z","publication":"PLoS Computational Biology","date_created":"2019-11-25T08:20:47Z","external_id":{"isi":["000500976100014"],"pmid":["31725712"]},"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"_id":"7103","month":"11","title":"Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture","date_updated":"2023-10-17T12:30:07Z","ec_funded":1,"date_published":"2019-11-01T00:00:00Z","article_processing_charge":"No","citation":{"ieee":"J. W. J. L. Wang, F. Lombardi, X. Zhang, C. Anaclet, and P. C. Ivanov, “Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture,” <i>PLoS Computational Biology</i>, vol. 15, no. 11. Public Library of Science, 2019.","short":"J.W.J.L. Wang, F. Lombardi, X. Zhang, C. Anaclet, P.C. Ivanov, PLoS Computational Biology 15 (2019).","apa":"Wang, J. W. J. L., Lombardi, F., Zhang, X., Anaclet, C., &#38; Ivanov, P. C. (2019). Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1007268\">https://doi.org/10.1371/journal.pcbi.1007268</a>","ista":"Wang JWJL, Lombardi F, Zhang X, Anaclet C, Ivanov PC. 2019. Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture. PLoS Computational Biology. 15(11), e1007268.","mla":"Wang, Jilin W. J. L., et al. “Non-Equilibrium Critical Dynamics of Bursts in θ and δ Rhythms as Fundamental Characteristic of Sleep and Wake Micro-Architecture.” <i>PLoS Computational Biology</i>, vol. 15, no. 11, e1007268, Public Library of Science, 2019, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1007268\">10.1371/journal.pcbi.1007268</a>.","ama":"Wang JWJL, Lombardi F, Zhang X, Anaclet C, Ivanov PC. Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture. <i>PLoS Computational Biology</i>. 2019;15(11). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1007268\">10.1371/journal.pcbi.1007268</a>","chicago":"Wang, Jilin W. J. L., Fabrizio Lombardi, Xiyun Zhang, Christelle Anaclet, and Plamen Ch. Ivanov. “Non-Equilibrium Critical Dynamics of Bursts in θ and δ Rhythms as Fundamental Characteristic of Sleep and Wake Micro-Architecture.” <i>PLoS Computational Biology</i>. Public Library of Science, 2019. <a href=\"https://doi.org/10.1371/journal.pcbi.1007268\">https://doi.org/10.1371/journal.pcbi.1007268</a>."},"type":"journal_article","file":[{"file_id":"7104","date_created":"2019-11-25T08:24:01Z","creator":"dernst","relation":"main_file","checksum":"2a096a9c6dcc6eaa94077b2603bc6c12","date_updated":"2020-07-14T12:47:49Z","content_type":"application/pdf","file_size":3982516,"file_name":"2019_PLOSComBio_Wang.pdf","access_level":"open_access"}],"article_type":"original","ddc":["570","000"],"language":[{"iso":"eng"}],"pmid":1,"status":"public","has_accepted_license":"1","abstract":[{"text":"Origin and functions of intermittent transitions among sleep stages, including short awakenings and arousals, constitute a challenge to the current homeostatic framework for sleep regulation, focusing on factors modulating sleep over large time scales. Here we propose that the complex micro-architecture characterizing the sleep-wake cycle results from an underlying non-equilibrium critical dynamics, bridging collective behaviors across spatio-temporal scales. We investigate θ and δ wave dynamics in control rats and in rats with lesions of sleep-promoting neurons in the parafacial zone. We demonstrate that intermittent bursts in θ and δ rhythms exhibit a complex temporal organization, with long-range power-law correlations and a robust duality of power law (θ-bursts, active phase) and exponential-like (δ-bursts, quiescent phase) duration distributions, typical features of non-equilibrium systems self-organizing at criticality. Crucially, such temporal organization relates to anti-correlated coupling between θ- and δ-bursts, and is independent of the dominant physiologic state and lesions, a solid indication of a basic principle in sleep dynamics.","lang":"eng"}],"publication_status":"published","quality_controlled":"1","oa_version":"Published Version","doi":"10.1371/journal.pcbi.1007268","day":"01","publisher":"Public Library of Science","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["1553-7358"]},"department":[{"_id":"GaTk"}],"author":[{"full_name":"Wang, Jilin W. J. L.","last_name":"Wang","first_name":"Jilin W. J. L."},{"id":"A057D288-3E88-11E9-986D-0CF4E5697425","first_name":"Fabrizio","last_name":"Lombardi","full_name":"Lombardi, Fabrizio","orcid":"0000-0003-2623-5249"},{"last_name":"Zhang","full_name":"Zhang, Xiyun","first_name":"Xiyun"},{"last_name":"Anaclet","full_name":"Anaclet, Christelle","first_name":"Christelle"},{"full_name":"Ivanov, Plamen Ch.","last_name":"Ivanov","first_name":"Plamen Ch."}],"isi":1,"year":"2019"},{"_id":"7105","external_id":{"isi":["000495888300009"],"pmid":["31685997"]},"date_created":"2019-11-25T08:55:00Z","publication":"Nature Cell Biology","page":"1370-1381","article_processing_charge":"No","date_published":"2019-11-01T00:00:00Z","title":"Persistent and polarized global actin flow is essential for directionality during cell migration","date_updated":"2023-09-06T11:08:52Z","month":"11","scopus_import":"1","oa":1,"intvolume":"        21","issue":"11","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025891","open_access":"1"}],"volume":21,"publisher":"Springer Nature","day":"01","doi":"10.1038/s41556-019-0411-5","oa_version":"Submitted Version","year":"2019","isi":1,"author":[{"last_name":"Yolland","full_name":"Yolland, Lawrence","first_name":"Lawrence"},{"first_name":"Mubarik","last_name":"Burki","full_name":"Burki, Mubarik"},{"first_name":"Stefania","last_name":"Marcotti","full_name":"Marcotti, Stefania"},{"first_name":"Andrei","last_name":"Luchici","full_name":"Luchici, Andrei"},{"full_name":"Kenny, Fiona N.","last_name":"Kenny","first_name":"Fiona N."},{"first_name":"John Robert","last_name":"Davis","full_name":"Davis, John Robert"},{"first_name":"Eduardo","last_name":"Serna-Morales","full_name":"Serna-Morales, Eduardo"},{"full_name":"Müller, Jan","last_name":"Müller","first_name":"Jan","id":"AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D"},{"last_name":"Sixt","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Andrew","full_name":"Davidson, Andrew","last_name":"Davidson"},{"last_name":"Wood","full_name":"Wood, Will","first_name":"Will"},{"first_name":"Linus J.","last_name":"Schumacher","full_name":"Schumacher, Linus J."},{"first_name":"Robert G.","full_name":"Endres, Robert G.","last_name":"Endres"},{"first_name":"Mark","last_name":"Miodownik","full_name":"Miodownik, Mark"},{"last_name":"Stramer","full_name":"Stramer, Brian M.","first_name":"Brian M."}],"publication_identifier":{"issn":["1465-7392"],"eissn":["1476-4679"]},"department":[{"_id":"MiSi"}],"article_type":"original","citation":{"ista":"Yolland L, Burki M, Marcotti S, Luchici A, Kenny FN, Davis JR, Serna-Morales E, Müller J, Sixt MK, Davidson A, Wood W, Schumacher LJ, Endres RG, Miodownik M, Stramer BM. 2019. Persistent and polarized global actin flow is essential for directionality during cell migration. Nature Cell Biology. 21(11), 1370–1381.","mla":"Yolland, Lawrence, et al. “Persistent and Polarized Global Actin Flow Is Essential for Directionality during Cell Migration.” <i>Nature Cell Biology</i>, vol. 21, no. 11, Springer Nature, 2019, pp. 1370–81, doi:<a href=\"https://doi.org/10.1038/s41556-019-0411-5\">10.1038/s41556-019-0411-5</a>.","ama":"Yolland L, Burki M, Marcotti S, et al. Persistent and polarized global actin flow is essential for directionality during cell migration. <i>Nature Cell Biology</i>. 2019;21(11):1370-1381. doi:<a href=\"https://doi.org/10.1038/s41556-019-0411-5\">10.1038/s41556-019-0411-5</a>","chicago":"Yolland, Lawrence, Mubarik Burki, Stefania Marcotti, Andrei Luchici, Fiona N. Kenny, John Robert Davis, Eduardo Serna-Morales, et al. “Persistent and Polarized Global Actin Flow Is Essential for Directionality during Cell Migration.” <i>Nature Cell Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41556-019-0411-5\">https://doi.org/10.1038/s41556-019-0411-5</a>.","ieee":"L. Yolland <i>et al.</i>, “Persistent and polarized global actin flow is essential for directionality during cell migration,” <i>Nature Cell Biology</i>, vol. 21, no. 11. Springer Nature, pp. 1370–1381, 2019.","apa":"Yolland, L., Burki, M., Marcotti, S., Luchici, A., Kenny, F. N., Davis, J. R., … Stramer, B. M. (2019). Persistent and polarized global actin flow is essential for directionality during cell migration. <i>Nature Cell Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41556-019-0411-5\">https://doi.org/10.1038/s41556-019-0411-5</a>","short":"L. Yolland, M. Burki, S. Marcotti, A. Luchici, F.N. Kenny, J.R. Davis, E. Serna-Morales, J. Müller, M.K. Sixt, A. Davidson, W. Wood, L.J. Schumacher, R.G. Endres, M. Miodownik, B.M. Stramer, Nature Cell Biology 21 (2019) 1370–1381."},"type":"journal_article","quality_controlled":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Cell migration is hypothesized to involve a cycle of behaviours beginning with leading edge extension. However, recent evidence suggests that the leading edge may be dispensable for migration, raising the question of what actually controls cell directionality. Here, we exploit the embryonic migration of Drosophila macrophages to bridge the different temporal scales of the behaviours controlling motility. This approach reveals that edge fluctuations during random motility are not persistent and are weakly correlated with motion. In contrast, flow of the actin network behind the leading edge is highly persistent. Quantification of actin flow structure during migration reveals a stable organization and asymmetry in the cell-wide flowfield that strongly correlates with cell directionality. This organization is regulated by a gradient of actin network compression and destruction, which is controlled by myosin contraction and cofilin-mediated disassembly. It is this stable actin-flow polarity, which integrates rapid fluctuations of the leading edge, that controls inherent cellular persistence."}],"status":"public","pmid":1,"language":[{"iso":"eng"}]},{"scopus_import":"1","volume":5,"intvolume":"         5","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"11","page":"1114-1119","publication":"Nature Plants","file_date_updated":"2020-10-14T08:54:49Z","external_id":{"isi":["000496526100010"],"pmid":["31712756"]},"date_created":"2019-11-25T09:08:04Z","project":[{"grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"}],"_id":"7106","month":"11","title":"PIN-driven auxin transport emerged early in streptophyte evolution","date_updated":"2023-09-06T11:09:49Z","ec_funded":1,"article_processing_charge":"No","date_published":"2019-11-01T00:00:00Z","type":"journal_article","citation":{"ama":"Skokan R, Medvecká E, Viaene T, et al. PIN-driven auxin transport emerged early in streptophyte evolution. <i>Nature Plants</i>. 2019;5(11):1114-1119. doi:<a href=\"https://doi.org/10.1038/s41477-019-0542-5\">10.1038/s41477-019-0542-5</a>","chicago":"Skokan, Roman, Eva Medvecká, Tom Viaene, Stanislav Vosolsobě, Marta Zwiewka, Karel Müller, Petr Skůpa, et al. “PIN-Driven Auxin Transport Emerged Early in Streptophyte Evolution.” <i>Nature Plants</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41477-019-0542-5\">https://doi.org/10.1038/s41477-019-0542-5</a>.","ista":"Skokan R, Medvecká E, Viaene T, Vosolsobě S, Zwiewka M, Müller K, Skůpa P, Karady M, Zhang Y, Janacek DP, Hammes UZ, Ljung K, Nodzyński T, Petrášek J, Friml J. 2019. PIN-driven auxin transport emerged early in streptophyte evolution. Nature Plants. 5(11), 1114–1119.","mla":"Skokan, Roman, et al. “PIN-Driven Auxin Transport Emerged Early in Streptophyte Evolution.” <i>Nature Plants</i>, vol. 5, no. 11, Springer Nature, 2019, pp. 1114–19, doi:<a href=\"https://doi.org/10.1038/s41477-019-0542-5\">10.1038/s41477-019-0542-5</a>.","short":"R. Skokan, E. Medvecká, T. Viaene, S. Vosolsobě, M. Zwiewka, K. Müller, P. Skůpa, M. Karady, Y. Zhang, D.P. Janacek, U.Z. Hammes, K. Ljung, T. Nodzyński, J. Petrášek, J. Friml, Nature Plants 5 (2019) 1114–1119.","apa":"Skokan, R., Medvecká, E., Viaene, T., Vosolsobě, S., Zwiewka, M., Müller, K., … Friml, J. (2019). PIN-driven auxin transport emerged early in streptophyte evolution. <i>Nature Plants</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41477-019-0542-5\">https://doi.org/10.1038/s41477-019-0542-5</a>","ieee":"R. Skokan <i>et al.</i>, “PIN-driven auxin transport emerged early in streptophyte evolution,” <i>Nature Plants</i>, vol. 5, no. 11. Springer Nature, pp. 1114–1119, 2019."},"file":[{"file_id":"8660","date_created":"2020-10-14T08:54:49Z","creator":"dernst","checksum":"94e0426856aad9a9bd0135d5436efbf1","relation":"main_file","file_size":1980851,"content_type":"application/pdf","date_updated":"2020-10-14T08:54:49Z","file_name":"2019_NaturePlants_Skokan_accepted.pdf","access_level":"open_access","success":1}],"article_type":"original","ddc":["580"],"pmid":1,"status":"public","has_accepted_license":"1","language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"text":"PIN-FORMED (PIN) transporters mediate directional, intercellular movement of the phytohormone auxin in land plants. To elucidate the evolutionary origins of this developmentally crucial mechanism, we analysed the single PIN homologue of a simple green alga Klebsormidium flaccidum. KfPIN functions as a plasma membrane-localized auxin exporter in land plants and heterologous models. While its role in algae remains unclear, PIN-driven auxin export is probably an ancient and conserved trait within streptophytes.","lang":"eng"}],"quality_controlled":"1","oa_version":"Submitted Version","doi":"10.1038/s41477-019-0542-5","day":"01","publisher":"Springer Nature","publication_identifier":{"issn":["2055-0278"]},"department":[{"_id":"JiFr"}],"year":"2019","author":[{"last_name":"Skokan","full_name":"Skokan, Roman","first_name":"Roman"},{"first_name":"Eva","full_name":"Medvecká, Eva","last_name":"Medvecká"},{"last_name":"Viaene","full_name":"Viaene, Tom","first_name":"Tom"},{"last_name":"Vosolsobě","full_name":"Vosolsobě, Stanislav","first_name":"Stanislav"},{"full_name":"Zwiewka, Marta","last_name":"Zwiewka","first_name":"Marta"},{"first_name":"Karel","last_name":"Müller","full_name":"Müller, Karel"},{"full_name":"Skůpa, Petr","last_name":"Skůpa","first_name":"Petr"},{"last_name":"Karady","full_name":"Karady, Michal","first_name":"Michal"},{"last_name":"Zhang","full_name":"Zhang, Yuzhou","first_name":"Yuzhou"},{"first_name":"Dorina P.","full_name":"Janacek, Dorina P.","last_name":"Janacek"},{"full_name":"Hammes, Ulrich Z.","last_name":"Hammes","first_name":"Ulrich Z."},{"first_name":"Karin","full_name":"Ljung, Karin","last_name":"Ljung"},{"full_name":"Nodzyński, Tomasz","last_name":"Nodzyński","first_name":"Tomasz"},{"first_name":"Jan","full_name":"Petrášek, Jan","last_name":"Petrášek"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"isi":1},{"publisher":"ACM","day":"01","doi":"10.1145/3314024","oa_version":"Preprint","arxiv":1,"year":"2019","author":[{"full_name":"Goaoc, Xavier","last_name":"Goaoc","first_name":"Xavier"},{"full_name":"Patak, Pavel","last_name":"Patak","first_name":"Pavel","id":"B593B804-1035-11EA-B4F1-947645A5BB83"},{"last_name":"Patakova","full_name":"Patakova, Zuzana","orcid":"0000-0002-3975-1683","first_name":"Zuzana","id":"48B57058-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Tancer, Martin","last_name":"Tancer","first_name":"Martin"},{"first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568","last_name":"Wagner"}],"isi":1,"department":[{"_id":"UlWa"}],"publication_identifier":{"issn":["0004-5411"]},"article_type":"original","citation":{"short":"X. Goaoc, P. Patak, Z. Patakova, M. Tancer, U. Wagner, Journal of the ACM 66 (2019).","apa":"Goaoc, X., Patak, P., Patakova, Z., Tancer, M., &#38; Wagner, U. (2019). Shellability is NP-complete. <i>Journal of the ACM</i>. ACM. <a href=\"https://doi.org/10.1145/3314024\">https://doi.org/10.1145/3314024</a>","ieee":"X. Goaoc, P. Patak, Z. Patakova, M. Tancer, and U. Wagner, “Shellability is NP-complete,” <i>Journal of the ACM</i>, vol. 66, no. 3. ACM, 2019.","chicago":"Goaoc, Xavier, Pavel Patak, Zuzana Patakova, Martin Tancer, and Uli Wagner. “Shellability Is NP-Complete.” <i>Journal of the ACM</i>. ACM, 2019. <a href=\"https://doi.org/10.1145/3314024\">https://doi.org/10.1145/3314024</a>.","ama":"Goaoc X, Patak P, Patakova Z, Tancer M, Wagner U. Shellability is NP-complete. <i>Journal of the ACM</i>. 2019;66(3). doi:<a href=\"https://doi.org/10.1145/3314024\">10.1145/3314024</a>","ista":"Goaoc X, Patak P, Patakova Z, Tancer M, Wagner U. 2019. Shellability is NP-complete. Journal of the ACM. 66(3), 21.","mla":"Goaoc, Xavier, et al. “Shellability Is NP-Complete.” <i>Journal of the ACM</i>, vol. 66, no. 3, 21, ACM, 2019, doi:<a href=\"https://doi.org/10.1145/3314024\">10.1145/3314024</a>."},"type":"journal_article","quality_controlled":"1","publication_status":"published","abstract":[{"lang":"eng","text":"We prove that for every d ≥ 2, deciding if a pure, d-dimensional, simplicial complex is shellable is NP-hard, hence NP-complete. This resolves a question raised, e.g., by Danaraj and Klee in 1978. Our reduction also yields that for every d ≥ 2 and k ≥ 0, deciding if a pure, d-dimensional, simplicial complex is k-decomposable is NP-hard. For d ≥ 3, both problems remain NP-hard when restricted to contractible pure d-dimensional complexes. Another simple corollary of our result is that it is NP-hard to decide whether a given poset is CL-shellable."}],"status":"public","language":[{"iso":"eng"}],"_id":"7108","external_id":{"arxiv":["1711.08436"],"isi":["000495406300007"]},"date_created":"2019-11-26T10:13:59Z","publication":"Journal of the ACM","article_processing_charge":"No","date_published":"2019-06-01T00:00:00Z","date_updated":"2023-09-06T11:10:58Z","title":"Shellability is NP-complete","month":"06","scopus_import":"1","article_number":"21","oa":1,"intvolume":"        66","issue":"3","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","related_material":{"record":[{"id":"184","relation":"earlier_version","status":"public"}]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/pdf/1711.08436.pdf"}],"volume":66},{"language":[{"iso":"eng"}],"status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"We show how to construct temporal testers for the logic MITL, a prominent linear-time logic for real-time systems. A temporal tester is a transducer that inputs a signal holding the Boolean value of atomic propositions and outputs the truth value of a formula along time. Here we consider testers over continuous-time Boolean signals that use clock variables to enforce duration constraints, as in timed automata. We first rewrite the MITL formula into a “simple” formula using a limited set of temporal modalities. We then build testers for these specific modalities and show how to compose testers for simple formulae into complex ones. Temporal testers can be turned into acceptors, yielding a compositional translation from MITL to timed automata. This construction is much simpler than previously known and remains asymptotically optimal. It supports both past and future operators and can easily be extended."}],"quality_controlled":"1","type":"journal_article","citation":{"ieee":"T. Ferrere, O. Maler, D. Ničković, and A. Pnueli, “From real-time logic to timed automata,” <i>Journal of the ACM</i>, vol. 66, no. 3. ACM, 2019.","apa":"Ferrere, T., Maler, O., Ničković, D., &#38; Pnueli, A. (2019). From real-time logic to timed automata. <i>Journal of the ACM</i>. ACM. <a href=\"https://doi.org/10.1145/3286976\">https://doi.org/10.1145/3286976</a>","short":"T. Ferrere, O. Maler, D. Ničković, A. Pnueli, Journal of the ACM 66 (2019).","mla":"Ferrere, Thomas, et al. “From Real-Time Logic to Timed Automata.” <i>Journal of the ACM</i>, vol. 66, no. 3, 19, ACM, 2019, doi:<a href=\"https://doi.org/10.1145/3286976\">10.1145/3286976</a>.","ista":"Ferrere T, Maler O, Ničković D, Pnueli A. 2019. From real-time logic to timed automata. Journal of the ACM. 66(3), 19.","chicago":"Ferrere, Thomas, Oded Maler, Dejan Ničković, and Amir Pnueli. “From Real-Time Logic to Timed Automata.” <i>Journal of the ACM</i>. ACM, 2019. <a href=\"https://doi.org/10.1145/3286976\">https://doi.org/10.1145/3286976</a>.","ama":"Ferrere T, Maler O, Ničković D, Pnueli A. From real-time logic to timed automata. <i>Journal of the ACM</i>. 2019;66(3). doi:<a href=\"https://doi.org/10.1145/3286976\">10.1145/3286976</a>"},"article_type":"original","department":[{"_id":"ToHe"}],"publication_identifier":{"issn":["0004-5411"]},"isi":1,"author":[{"last_name":"Ferrere","orcid":"0000-0001-5199-3143","full_name":"Ferrere, Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas"},{"first_name":"Oded","last_name":"Maler","full_name":"Maler, Oded"},{"first_name":"Dejan","full_name":"Ničković, Dejan","last_name":"Ničković"},{"last_name":"Pnueli","full_name":"Pnueli, Amir","first_name":"Amir"}],"year":"2019","oa_version":"None","doi":"10.1145/3286976","day":"01","publisher":"ACM","volume":66,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"3","intvolume":"        66","article_number":"19","scopus_import":"1","month":"05","date_updated":"2023-09-06T11:11:56Z","title":"From real-time logic to timed automata","date_published":"2019-05-01T00:00:00Z","article_processing_charge":"No","publication":"Journal of the ACM","date_created":"2019-11-26T10:22:32Z","external_id":{"isi":["000495406300005"]},"_id":"7109","project":[{"name":"Rigorous Systems Engineering","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","grant_number":"S 11407_N23"},{"name":"The Wittgenstein Prize","_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211","call_identifier":"FWF"}]},{"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"12897"}]},"volume":38,"article_number":"157","oa":1,"intvolume":"        38","issue":"6","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","scopus_import":"1","date_updated":"2024-03-25T23:30:26Z","title":"X-CAD: Optimizing CAD Models with Extended Finite Elements","month":"11","article_processing_charge":"No","date_published":"2019-11-06T00:00:00Z","ec_funded":1,"publication":"ACM Transactions on Graphics","file_date_updated":"2020-07-14T12:47:49Z","project":[{"_id":"24F9549A-B435-11E9-9278-68D0E5697425","grant_number":"715767","call_identifier":"H2020","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"_id":"7117","external_id":{"isi":["000498397300007"]},"date_created":"2019-11-26T14:22:09Z","publication_status":"published","abstract":[{"text":"We propose a novel generic shape optimization method for CAD models based on the eXtended Finite Element Method (XFEM). Our method works directly on the intersection between the model and a regular simulation grid, without the need to mesh or remesh, thus removing a bottleneck of classical shape optimization strategies. This is made possible by a novel hierarchical integration scheme that accurately integrates finite element quantities with sub-element precision. For optimization, we efficiently compute analytical shape derivatives of the entire framework, from model intersection to integration rule generation and XFEM simulation. Moreover, we describe a differentiable projection of shape parameters onto a constraint manifold spanned by user-specified shape preservation, consistency, and manufacturability constraints. We demonstrate the utility of our approach by optimizing mass distribution, strength-to-weight ratio, and inverse elastic shape design objectives directly on parameterized 3D CAD models.","lang":"eng"}],"status":"public","has_accepted_license":"1","language":[{"iso":"eng"}],"quality_controlled":"1","file":[{"file_id":"7119","creator":"bbickel","date_created":"2019-11-26T14:24:26Z","checksum":"56a2fb019adcb556d2b022f5e5acb68c","relation":"supplementary_material","title":"X-CAD Supplemental Material","date_updated":"2020-07-14T12:47:49Z","content_type":"application/pdf","file_size":1673176,"file_name":"xcad_sup_mat_siga19.pdf","access_level":"open_access"},{"checksum":"5f29d76aceb5102e766cbab9b17d776e","relation":"main_file","file_size":14563618,"date_updated":"2020-07-14T12:47:49Z","title":"X-CAD: Optimizing CAD Models with Extended Finite Elements","content_type":"application/pdf","file_name":"XCAD_authors_version.pdf","access_level":"open_access","file_id":"7120","description":"This is the author's version of the work.","creator":"bbickel","date_created":"2019-11-26T14:24:27Z"},{"file_id":"7121","creator":"bbickel","date_created":"2019-11-26T14:27:37Z","file_size":259979129,"date_updated":"2020-07-14T12:47:49Z","content_type":"video/mp4","relation":"main_file","checksum":"0d31e123286cbec9e28b2001c2bb0d55","access_level":"open_access","file_name":"XCAD_video.mp4"}],"type":"journal_article","citation":{"ama":"Hafner C, Schumacher C, Knoop E, Auzinger T, Bickel B, Bächer M. X-CAD: Optimizing CAD Models with Extended Finite Elements. <i>ACM Transactions on Graphics</i>. 2019;38(6). doi:<a href=\"https://doi.org/10.1145/3355089.3356576\">10.1145/3355089.3356576</a>","chicago":"Hafner, Christian, Christian Schumacher, Espen Knoop, Thomas Auzinger, Bernd Bickel, and Moritz Bächer. “X-CAD: Optimizing CAD Models with Extended Finite Elements.” <i>ACM Transactions on Graphics</i>. ACM, 2019. <a href=\"https://doi.org/10.1145/3355089.3356576\">https://doi.org/10.1145/3355089.3356576</a>.","mla":"Hafner, Christian, et al. “X-CAD: Optimizing CAD Models with Extended Finite Elements.” <i>ACM Transactions on Graphics</i>, vol. 38, no. 6, 157, ACM, 2019, doi:<a href=\"https://doi.org/10.1145/3355089.3356576\">10.1145/3355089.3356576</a>.","ista":"Hafner C, Schumacher C, Knoop E, Auzinger T, Bickel B, Bächer M. 2019. X-CAD: Optimizing CAD Models with Extended Finite Elements. ACM Transactions on Graphics. 38(6), 157.","short":"C. Hafner, C. Schumacher, E. Knoop, T. Auzinger, B. Bickel, M. Bächer, ACM Transactions on Graphics 38 (2019).","apa":"Hafner, C., Schumacher, C., Knoop, E., Auzinger, T., Bickel, B., &#38; Bächer, M. (2019). X-CAD: Optimizing CAD Models with Extended Finite Elements. <i>ACM Transactions on Graphics</i>. ACM. <a href=\"https://doi.org/10.1145/3355089.3356576\">https://doi.org/10.1145/3355089.3356576</a>","ieee":"C. Hafner, C. Schumacher, E. Knoop, T. Auzinger, B. Bickel, and M. Bächer, “X-CAD: Optimizing CAD Models with Extended Finite Elements,” <i>ACM Transactions on Graphics</i>, vol. 38, no. 6. ACM, 2019."},"ddc":["000"],"article_type":"original","department":[{"_id":"BeBi"}],"publication_identifier":{"issn":["0730-0301"]},"year":"2019","isi":1,"author":[{"last_name":"Hafner","full_name":"Hafner, Christian","id":"400429CC-F248-11E8-B48F-1D18A9856A87","first_name":"Christian"},{"first_name":"Christian","last_name":"Schumacher","full_name":"Schumacher, Christian"},{"first_name":"Espen","last_name":"Knoop","full_name":"Knoop, Espen"},{"last_name":"Auzinger","orcid":"0000-0002-1546-3265","full_name":"Auzinger, Thomas","first_name":"Thomas","id":"4718F954-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-6511-9385","full_name":"Bickel, Bernd","last_name":"Bickel","first_name":"Bernd","id":"49876194-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Moritz","full_name":"Bächer, Moritz","last_name":"Bächer"}],"doi":"10.1145/3355089.3356576","oa_version":"Submitted Version","publisher":"ACM","day":"06"},{"article_processing_charge":"No","conference":{"end_date":"2018-12-19","location":"Miami Beach, FL, United States","start_date":"2018-12-17","name":"CDC: Conference on Decision and Control"},"year":"2019","isi":1,"author":[{"full_name":"Khirirat, Sarit","last_name":"Khirirat","first_name":"Sarit"},{"first_name":"Mikael","full_name":"Johansson, Mikael","last_name":"Johansson"},{"first_name":"Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","last_name":"Alistarh","full_name":"Alistarh, Dan-Adrian","orcid":"0000-0003-3650-940X"}],"date_published":"2019-01-21T00:00:00Z","publication_identifier":{"issn":["0743-1546"],"isbn":["9781538613955"]},"department":[{"_id":"DaAl"}],"title":"Gradient compression for communication-limited convex optimization","date_updated":"2023-09-06T11:14:55Z","month":"01","publisher":"IEEE","_id":"7122","external_id":{"isi":["000458114800023"]},"day":"21","date_created":"2019-11-26T15:07:49Z","publication":"2018 IEEE Conference on Decision and Control","doi":"10.1109/cdc.2018.8619625","oa_version":"None","quality_controlled":"1","article_number":"8619625","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","abstract":[{"text":"Data-rich applications in machine-learning and control have motivated an intense research on large-scale optimization. Novel algorithms have been proposed and shown to have optimal convergence rates in terms of iteration counts. However, their practical performance is severely degraded by the cost of exchanging high-dimensional gradient vectors between computing nodes. Several gradient compression heuristics have recently been proposed to reduce communications, but few theoretical results exist that quantify how they impact algorithm convergence. This paper establishes and strengthens the convergence guarantees for gradient descent under a family of gradient compression techniques. For convex optimization problems, we derive admissible step sizes and quantify both the number of iterations and the number of bits that need to be exchanged to reach a target accuracy. Finally, we validate the performance of different gradient compression techniques in simulations. The numerical results highlight the properties of different gradient compression algorithms and confirm that fast convergence with limited information exchange is possible.","lang":"eng"}],"publication_status":"published","status":"public","language":[{"iso":"eng"}],"citation":{"ieee":"S. Khirirat, M. Johansson, and D.-A. Alistarh, “Gradient compression for communication-limited convex optimization,” in <i>2018 IEEE Conference on Decision and Control</i>, Miami Beach, FL, United States, 2019.","apa":"Khirirat, S., Johansson, M., &#38; Alistarh, D.-A. (2019). Gradient compression for communication-limited convex optimization. In <i>2018 IEEE Conference on Decision and Control</i>. Miami Beach, FL, United States: IEEE. <a href=\"https://doi.org/10.1109/cdc.2018.8619625\">https://doi.org/10.1109/cdc.2018.8619625</a>","short":"S. Khirirat, M. Johansson, D.-A. Alistarh, in:, 2018 IEEE Conference on Decision and Control, IEEE, 2019.","ista":"Khirirat S, Johansson M, Alistarh D-A. 2019. Gradient compression for communication-limited convex optimization. 2018 IEEE Conference on Decision and Control. CDC: Conference on Decision and Control, 8619625.","mla":"Khirirat, Sarit, et al. “Gradient Compression for Communication-Limited Convex Optimization.” <i>2018 IEEE Conference on Decision and Control</i>, 8619625, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/cdc.2018.8619625\">10.1109/cdc.2018.8619625</a>.","ama":"Khirirat S, Johansson M, Alistarh D-A. Gradient compression for communication-limited convex optimization. In: <i>2018 IEEE Conference on Decision and Control</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/cdc.2018.8619625\">10.1109/cdc.2018.8619625</a>","chicago":"Khirirat, Sarit, Mikael Johansson, and Dan-Adrian Alistarh. “Gradient Compression for Communication-Limited Convex Optimization.” In <i>2018 IEEE Conference on Decision and Control</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/cdc.2018.8619625\">https://doi.org/10.1109/cdc.2018.8619625</a>."},"type":"conference","scopus_import":"1"},{"supervisor":[{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","first_name":"Harald L","last_name":"Janovjak","orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L"}],"file_date_updated":"2020-07-14T12:47:50Z","page":"95","_id":"7132","date_created":"2019-11-27T09:07:14Z","date_updated":"2024-03-25T23:30:11Z","title":"Design and characterization of methods and biological components to realize synthetic neurotransmission","month":"06","article_processing_charge":"No","date_published":"2019-06-27T00:00:00Z","related_material":{"record":[{"id":"6266","status":"public","relation":"old_edition"}]},"alternative_title":["ISTA Thesis"],"oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","doi":"10.15479/at:ista:7132","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","day":"27","publication_identifier":{"issn":["2663-337X"]},"department":[{"_id":"HaJa"}],"degree_awarded":"PhD","year":"2019","author":[{"first_name":"Catherine","id":"3EEDE19A-F248-11E8-B48F-1D18A9856A87","last_name":"Mckenzie","full_name":"Mckenzie, Catherine"}],"file":[{"file_name":"McKenzie PhD Thesis August 2018 - Corrected Final.docx","access_level":"closed","checksum":"34d0fe0f6e0af97b5937205a3e350423","relation":"source_file","date_updated":"2020-07-14T12:47:50Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_size":5054633,"date_created":"2019-11-27T09:06:10Z","creator":"dernst","file_id":"7133"},{"checksum":"140dfb5e3df7edca34f4b6fcc55d876f","relation":"main_file","date_updated":"2020-07-14T12:47:50Z","content_type":"application/pdf","file_size":3231837,"file_name":"McKenzie PhD Thesis August 2018 - Corrected Final.pdf","access_level":"open_access","file_id":"7134","date_created":"2019-11-27T09:06:10Z","creator":"dernst"}],"type":"dissertation","citation":{"ieee":"C. Mckenzie, “Design and characterization of methods and biological components to realize synthetic neurotransmission,” Institute of Science and Technology Austria, 2019.","short":"C. Mckenzie, Design and Characterization of Methods and Biological Components to Realize Synthetic Neurotransmission, Institute of Science and Technology Austria, 2019.","apa":"Mckenzie, C. (2019). <i>Design and characterization of methods and biological components to realize synthetic neurotransmission</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:7132\">https://doi.org/10.15479/at:ista:7132</a>","mla":"Mckenzie, Catherine. <i>Design and Characterization of Methods and Biological Components to Realize Synthetic Neurotransmission</i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/at:ista:7132\">10.15479/at:ista:7132</a>.","ista":"Mckenzie C. 2019. Design and characterization of methods and biological components to realize synthetic neurotransmission. Institute of Science and Technology Austria.","ama":"Mckenzie C. Design and characterization of methods and biological components to realize synthetic neurotransmission. 2019. doi:<a href=\"https://doi.org/10.15479/at:ista:7132\">10.15479/at:ista:7132</a>","chicago":"Mckenzie, Catherine. “Design and Characterization of Methods and Biological Components to Realize Synthetic Neurotransmission.” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/at:ista:7132\">https://doi.org/10.15479/at:ista:7132</a>."},"ddc":["571","573"],"publication_status":"published","abstract":[{"lang":"eng","text":"A major challenge in neuroscience research is to dissect the circuits that orchestrate behavior in health and disease. Proteins from a wide range of non-mammalian species, such as microbial opsins, have been successfully transplanted to specific neuronal targets to override their natural communication patterns. The goal of our work is to manipulate synaptic communication in a manner that closely incorporates the functional intricacies of synapses by preserving temporal encoding (i.e. the firing pattern of the presynaptic neuron) and connectivity (i.e. target specific synapses rather than specific neurons). Our strategy to achieve this goal builds on the use of non-mammalian transplants to create a synthetic synapse. The mode of modulation comes from pre-synaptic uptake of a synthetic neurotransmitter (SN) into synaptic vesicles by means of a genetically targeted transporter selective for the SN. Upon natural vesicular release, exposure of the SN to the synaptic cleft will modify the post-synaptic potential through an orthogonal ligand gated ion channel. To achieve this goal we have functionally characterized a mixed cationic methionine-gated ion channel from Arabidopsis thaliana, designed a method to functionally characterize a synthetic transporter in isolated synaptic vesicles without the need for transgenic animals, identified and extracted multiple prokaryotic uptake systems that are substrate specific for methionine (Met), and established a primary/cell line co-culture system that would allow future combinatorial testing of this orthogonal transmitter-transporter-channel trifecta.\r\nSynthetic synapses will provide a unique opportunity to manipulate synaptic communication while maintaining the electrophysiological integrity of the pre-synaptic cell. In this way, information may be preserved that was generated in upstream circuits and that could be essential for concerted function and information processing."}],"has_accepted_license":"1","status":"public","language":[{"iso":"eng"}]},{"external_id":{"isi":["000489100301043"],"arxiv":["1702.08476"]},"date_created":"2019-11-28T10:19:21Z","_id":"7136","publication":"2019 IEEE International Symposium on Information Theory","article_processing_charge":"No","date_published":"2019-07-01T00:00:00Z","month":"07","title":"Strong chain rules for min-entropy under few bits spoiled","date_updated":"2023-09-06T11:15:41Z","scopus_import":"1","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_number":"8849240","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1702.08476"}],"day":"01","publisher":"IEEE","arxiv":1,"oa_version":"Preprint","doi":"10.1109/isit.2019.8849240","conference":{"start_date":"2019-07-07","location":"Paris, France","end_date":"2019-07-12","name":"ISIT: International Symposium on Information Theory"},"year":"2019","author":[{"last_name":"Skórski","full_name":"Skórski, Maciej","first_name":"Maciej","id":"EC09FA6A-02D0-11E9-8223-86B7C91467DD"}],"isi":1,"publication_identifier":{"isbn":["9781538692912"]},"department":[{"_id":"KrPi"}],"type":"conference","citation":{"ieee":"M. Skórski, “Strong chain rules for min-entropy under few bits spoiled,” in <i>2019 IEEE International Symposium on Information Theory</i>, Paris, France, 2019.","apa":"Skórski, M. (2019). Strong chain rules for min-entropy under few bits spoiled. In <i>2019 IEEE International Symposium on Information Theory</i>. Paris, France: IEEE. <a href=\"https://doi.org/10.1109/isit.2019.8849240\">https://doi.org/10.1109/isit.2019.8849240</a>","short":"M. Skórski, in:, 2019 IEEE International Symposium on Information Theory, IEEE, 2019.","ista":"Skórski M. 2019. Strong chain rules for min-entropy under few bits spoiled. 2019 IEEE International Symposium on Information Theory. ISIT: International Symposium on Information Theory, 8849240.","mla":"Skórski, Maciej. “Strong Chain Rules for Min-Entropy under Few Bits Spoiled.” <i>2019 IEEE International Symposium on Information Theory</i>, 8849240, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/isit.2019.8849240\">10.1109/isit.2019.8849240</a>.","ama":"Skórski M. Strong chain rules for min-entropy under few bits spoiled. In: <i>2019 IEEE International Symposium on Information Theory</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/isit.2019.8849240\">10.1109/isit.2019.8849240</a>","chicago":"Skórski, Maciej. “Strong Chain Rules for Min-Entropy under Few Bits Spoiled.” In <i>2019 IEEE International Symposium on Information Theory</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/isit.2019.8849240\">https://doi.org/10.1109/isit.2019.8849240</a>."},"quality_controlled":"1","status":"public","language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"text":"It is well established that the notion of min-entropy fails to satisfy the \\emph{chain rule} of the form H(X,Y)=H(X|Y)+H(Y), known for Shannon Entropy. Such a property would help to analyze how min-entropy is split among smaller blocks. Problems of this kind arise for example when constructing extractors and dispersers.\r\nWe show that any sequence of variables exhibits a very strong strong block-source structure (conditional distributions of blocks are nearly flat) when we \\emph{spoil few correlated bits}. This implies, conditioned on the spoiled bits, that \\emph{splitting-recombination properties} hold. In particular, we have many nice properties that min-entropy doesn't obey in general, for example strong chain rules, \"information can't hurt\" inequalities, equivalences of average and worst-case conditional entropy definitions and others. Quantitatively, for any sequence X1,…,Xt of random variables over an alphabet X we prove that, when conditioned on m=t⋅O(loglog|X|+loglog(1/ϵ)+logt) bits of auxiliary information, all conditional distributions of the form Xi|X<i are ϵ-close to be nearly flat (only a constant factor away). The argument is combinatorial (based on simplex coverings).\r\nThis result may be used as a generic tool for \\emph{exhibiting block-source structures}. We demonstrate this by reproving the fundamental converter due to Nisan and Zuckermann (\\emph{J. Computer and System Sciences, 1996}), which shows that sampling blocks from a min-entropy source roughly preserves the entropy rate. Our bound implies, only by straightforward chain rules, an additive loss of o(1) (for sufficiently many samples), which qualitatively meets the first tighter analysis of this problem due to Vadhan (\\emph{CRYPTO'03}), obtained by large deviation techniques. ","lang":"eng"}]}]