Biophysics of information processing in gene regulation
Project Period: 2016-01-01 – 2018-12-31
Funding Organisation:
FWF
Principal Investigator
Department(s)
Grant Number
P28844-B27
Funding Organisation
FWF
19 Publications
2022 | Published | Journal Article | IST-REx-ID: 12156 |
Eukaryotic gene regulation at equilibrium, or non?
B. Zoller, T. Gregor, G. Tkačik, Current Opinion in Systems Biology 31 (2022).
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B. Zoller, T. Gregor, G. Tkačik, Current Opinion in Systems Biology 31 (2022).
2021 | Published | Journal Article | IST-REx-ID: 8997 |
Minimal biophysical model of combined antibiotic action
B. Kavcic, G. Tkačik, M.T. Bollenbach, PLOS Computational Biology 17 (2021).
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B. Kavcic, G. Tkačik, M.T. Bollenbach, PLOS Computational Biology 17 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9226 |
The many bits of positional information
G. Tkačik, T. Gregor, Development 148 (2021).
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G. Tkačik, T. Gregor, Development 148 (2021).
2020 | Published | Preprint | IST-REx-ID: 7673 |
A minimal biophysical model of combined antibiotic action
B. Kavcic, G. Tkačik, M.T. Bollenbach, BioRxiv (2020).
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B. Kavcic, G. Tkačik, M.T. Bollenbach, BioRxiv (2020).
2020 | Published | Journal Article | IST-REx-ID: 8250 |
Mechanisms of drug interactions between translation-inhibiting antibiotics
B. Kavcic, G. Tkačik, M.T. Bollenbach, Nature Communications 11 (2020).
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B. Kavcic, G. Tkačik, M.T. Bollenbach, Nature Communications 11 (2020).
2019 | Published | Journal Article | IST-REx-ID: 5945 |
Optimal decoding of cellular identities in a genetic network
M.D. Petkova, G. Tkačik, W. Bialek, E.F. Wieschaus, T. Gregor, Cell 176 (2019) 844–855.e15.
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M.D. Petkova, G. Tkačik, W. Bialek, E.F. Wieschaus, T. Gregor, Cell 176 (2019) 844–855.e15.
2019 | Submitted | Preprint | IST-REx-ID: 7552 |
Action at a distance in transcriptional regulation
W. Bialek, T. Gregor, G. Tkačik, ArXiv:1912.08579 (n.d.).
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W. Bialek, T. Gregor, G. Tkačik, ArXiv:1912.08579 (n.d.).
2019 | Published | Thesis | IST-REx-ID: 6071 |
Coevolution of transcription factors and their binding sites in sequence space
R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in Sequence Space, Institute of Science and Technology Austria, 2019.
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R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in Sequence Space, Institute of Science and Technology Austria, 2019.
2019 | Published | Journal Article | IST-REx-ID: 6900 |
Estimating information in time-varying signals
S.A. Cepeda Humerez, J. Ruess, G. Tkačik, PLoS Computational Biology 15 (2019) e1007290.
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S.A. Cepeda Humerez, J. Ruess, G. Tkačik, PLoS Computational Biology 15 (2019) e1007290.
2018 | Published | Journal Article | IST-REx-ID: 281 |
Distributed and dynamic intracellular organization of extracellular information
A. Granados, J. Pietsch, S.A. Cepeda Humerez, I. Farquhar, G. Tkačik, P. Swain, PNAS 115 (2018) 6088–6093.
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A. Granados, J. Pietsch, S.A. Cepeda Humerez, I. Farquhar, G. Tkačik, P. Swain, PNAS 115 (2018) 6088–6093.
2018 | Research Data | IST-REx-ID: 5587 |
Supporting materials "STATISTICAL MECHANICS FOR METABOLIC NETWORKS IN STEADY-STATE GROWTH"
D. De Martino, G. Tkačik, (2018).
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D. De Martino, G. Tkačik, (2018).
2018 | Published | Journal Article | IST-REx-ID: 161 |
Statistical mechanics for metabolic networks during steady state growth
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
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D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
2017 | Published | Journal Article | IST-REx-ID: 613 |
Shaping bacterial population behavior through computer interfaced control of individual cells
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
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R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
2017 | Published | Journal Article | IST-REx-ID: 665
Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, Science 356 (2017) 311–315.
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T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, Science 356 (2017) 311–315.
2017 | Published | Journal Article | IST-REx-ID: 943 |
Decoding of position in the developing neural tube from antiparallel morphogen gradients
M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkačik, T. Bollenbach, J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
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M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkačik, T. Bollenbach, J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
2017 | Published | Journal Article | IST-REx-ID: 955 |
Evolution of new regulatory functions on biophysically realistic fitness landscapes
T. Friedlander, R. Prizak, N.H. Barton, G. Tkačik, Nature Communications 8 (2017).
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T. Friedlander, R. Prizak, N.H. Barton, G. Tkačik, Nature Communications 8 (2017).
2016 | Published | Journal Article | IST-REx-ID: 1242 |
Extending the dynamic range of transcription factor action by translational regulation
T.R. Sokolowski, A. Walczak, W. Bialek, G. Tkačik, Physical Review E Statistical Nonlinear and Soft Matter Physics 93 (2016).
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T.R. Sokolowski, A. Walczak, W. Bialek, G. Tkačik, Physical Review E Statistical Nonlinear and Soft Matter Physics 93 (2016).
2016 | Published | Journal Article | IST-REx-ID: 1270 |
Beyond the French flag model: Exploiting spatial and gene regulatory interactions for positional information
P. Hillenbrand, U. Gerland, G. Tkačik, PLoS One 11 (2016).
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P. Hillenbrand, U. Gerland, G. Tkačik, PLoS One 11 (2016).
2016 | Published | Journal Article | IST-REx-ID: 1358 |
Intrinsic limits to gene regulation by global crosstalk
T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkačik, Nature Communications 7 (2016).
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T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkačik, Nature Communications 7 (2016).